MCID: URT016
MIFTS: 38

Urethral Diverticulum

Categories: Nephrological diseases

Aliases & Classifications for Urethral Diverticulum

MalaCards integrated aliases for Urethral Diverticulum:

Name: Urethral Diverticulum 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9341
ICD10 33 N36.1
ICD9CM 35 599.2
NCIt 50 C39861
SNOMED-CT 68 90531003
UMLS 73 C0152443

Summaries for Urethral Diverticulum

MalaCards based summary : Urethral Diverticulum is related to clear cell adenocarcinoma and nephrogenic adenoma. An important gene associated with Urethral Diverticulum is KIDINS220 (Kinase D Interacting Substrate 220), and among its related pathways/superpathways are Adhesion and FOXA1 transcription factor network. The drugs leucovorin and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include prostate, testes and skin, and related phenotypes are cellular and homeostasis/metabolism

Wikipedia : 76 A urethral diverticulum is a condition where the urethra or the periurethral glands push into the... more...

Related Diseases for Urethral Diverticulum

Diseases related to Urethral Diverticulum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 clear cell adenocarcinoma 30.4 AMACR KLK3 KRT7 PAX8
2 nephrogenic adenoma 30.2 AMACR KLK3 KRT7 NKX3-1 PAX8
3 acute cystitis 29.7 KLK3 MCU
4 adenocarcinoma 10.6
5 adenoma 10.4
6 squamous cell carcinoma 10.2
7 renal pelvis transitional cell carcinoma 10.2 KRT7 UPK3A
8 prostate sarcoma 10.2 KLK3 NKX3-1
9 glandular cystitis 10.2 KRT7 UPK3A
10 vulval paget's disease 10.2 KRT7 UPK3A
11 vulvar disease 10.2 KRT7 UPK3A
12 chronic cystitis 10.2 KRT7 UPK3A
13 vulva adenocarcinoma 10.2 KRT7 UPK3A
14 nephrogenic adenoma of urinary bladder 10.2 KRT7 PAX8
15 clear cell papillary renal cell carcinoma 10.2 AMACR KRT7
16 papillary adenoma 10.2 AMACR KRT7
17 bladder benign neoplasm 10.2 KRT7 PAX8
18 prostate small cell carcinoma 10.1 AMACR KLK3
19 urethral syndrome 10.1 KIDINS220 KLK3
20 ovarian mucinous adenocarcinoma 10.1 AMACR KRT7
21 radiation cystitis 10.1 KLK3 UPK3A
22 renal pelvis adenocarcinoma 10.1 KRT7 PAX8
23 sensory organ benign neoplasm 10.1 KRT7 PAX8
24 endocervical carcinoma 10.1 KRT7 PAX8
25 hypospadias 10.1
26 transitional cell carcinoma 10.1
27 paraplegia 10.1
28 in situ carcinoma 10.1
29 rete testis neoplasm 10.1 KLK3 PAX8
30 seminal vesicle adenocarcinoma 10.1 KLK3 KRT7
31 rectal disease 10.1 KIDINS220 KLK3
32 ovarian cystic teratoma 10.1 KRT7 PVR
33 endocervical adenocarcinoma 10.1 KRT7 PAX8
34 seminal vesicle tumor 10.1 KLK3 KRT7
35 vulva cancer 10.1 KRT7 UPK3A
36 prostate squamous cell carcinoma 10.1 KLK3 KRT7
37 cervical adenosquamous carcinoma 10.1 KRT7 PAX8
38 male reproductive organ benign neoplasm 10.1 KLK3 WT1
39 adenocarcinoma in situ 10.1 KRT7 PAX8
40 urethra adenocarcinoma 10.1 AMACR KLK3 UPK3A
41 urethra clear cell adenocarcinoma 10.1 AMACR KLK3 UPK3A
42 benign mesothelioma 10.1 KRT7 WT1
43 urethral benign neoplasm 10.1 AMACR KLK3 UPK3A
44 nodular hidradenoma 10.1 FUT4 KRT7
45 female reproductive endometrioid cancer 10.1 KRT7 WT1
46 adenomatoid tumor 10.1 KRT7 WT1
47 male reproductive organ cancer 10.1 AMACR KLK3 NKX3-1
48 male reproductive system disease 10.1 AMACR KLK3 NKX3-1
49 reproductive system disease 10.1 AMACR KLK3 NKX3-1
50 prostatitis 10.1 KLK3 NKX3-1

Comorbidity relations with Urethral Diverticulum via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Urethral Diverticulum:



Diseases related to Urethral Diverticulum

Symptoms & Phenotypes for Urethral Diverticulum

MGI Mouse Phenotypes related to Urethral Diverticulum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.56 F3 FUT4 KIDINS220 KRT7 MCU NKX3-1
2 homeostasis/metabolism MP:0005376 9.28 AMACR F3 HGD KRT7 MCU NKX3-1

Drugs & Therapeutics for Urethral Diverticulum

Drugs for Urethral Diverticulum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Not Applicable 58-05-9 6006 143
2
Trimethoprim Approved, Vet_approved Not Applicable 738-70-5 5578
3
Sulfamethoxazole Approved Not Applicable 723-46-6 5329
4
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
5 Antiparasitic Agents Not Applicable
6 Antibiotics, Antitubercular Not Applicable
7 Vitamin B9 Not Applicable
8 Anti-Infective Agents, Urinary Not Applicable
9 Antiprotozoal Agents Not Applicable
10 Vitamin B Complex Not Applicable
11 Anti-Infective Agents Not Applicable
12 Cytochrome P-450 Enzyme Inhibitors Not Applicable
13 Anti-Bacterial Agents Not Applicable
14 Folic Acid Antagonists Not Applicable
15 Renal Agents Not Applicable
16 Antimalarials Not Applicable
17 Trimethoprim, Sulfamethoxazole Drug Combination Not Applicable
18 Folate Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Primary Urethral Realignment Versus Suprapubic Cystostomy After Pelvic Fracture Urethral Injury Recruiting NCT03195179
2 Prophylactic Antibiotics or Placebo After Hypospadias Repair Active, not recruiting NCT02096159 Not Applicable trimethoprim-sulfamethoxazole

Search NIH Clinical Center for Urethral Diverticulum

Genetic Tests for Urethral Diverticulum

Anatomical Context for Urethral Diverticulum

MalaCards organs/tissues related to Urethral Diverticulum:

41
Prostate, Testes, Skin, Kidney, Colon, Ovary, Testis

Publications for Urethral Diverticulum

Articles related to Urethral Diverticulum:

(show top 50) (show all 335)
# Title Authors Year
1
Female urethral diverticulum containing large calculi. ( 29686963 )
2018
2
Surgical correction of urethral diverticulum in a female pseudo-hermaphrodite crossbred calf. ( 29805465 )
2018
3
Suspected congenital urethral diverticulum in a dog. ( 29599553 )
2018
4
Incidental Finding of Urethral Diverticulum in a Woman with History of Recurrent Urinary Tract Infections. ( 29692697 )
2018
5
Urethral diverticulum repair using diverticulum wall: A new technique for preparing covering flap layer. ( 29998061 )
2018
6
Rare cause of voiding dysfunction in an adult man: urethral diverticulum compressing the anterior urethra. ( 30012683 )
2018
7
Managing female urethral diverticulum with a standardized technique using a pacifier-trick artifice to facilitate dissection. ( 30178127 )
2018
8
Enterolithiasis in posterior urethral diverticulum: an uncommon complication following surgery for anorectal malformation. ( 30209147 )
2018
9
Urethral diverticulum carcinoma in females-a case series and review of the English and Japanese literature. ( 30211061 )
2018
10
Periurethral Abscess Complicating Urethral Diverticulum. ( 30253950 )
2018
11
Female urethral diverticulum containing calculi: A rare and tricky condition. ( 30263891 )
2018
12
Correlation of MRI features of urethral diverticulum and pre- and post-operative stress urinary incontinence. ( 30411812 )
2018
13
Giant urethral diverticulum calculus revealed by peri-urethral abscess. ( 30430479 )
2018
14
A Case of Urethral Diverticulum with Surgical Repair Using Cadaveric Pericardial Tissue. ( 30519496 )
2018
15
Diagnosis of urethral diverticulum mimicking pelvic organ prolapse with translabial ultrasonography. ( 28666694 )
2017
16
Preliminary report on the effect of urethral diverticulum magnetic resonance imaging configuration on the incidence of new onset urodynamic stress urinary incontinence following excision. ( 29118531 )
2017
17
Female Urethral Diverticulum Carcinoma: A Case Report and Literature Review. ( 28630778 )
2017
18
Anastomotic Urethroplasty for an Obstructing Calculus Within a Bulbar Urethral Diverticulum and Urethral Stricture. ( 27981035 )
2017
19
A rare presentation of alkaptonuria: Extensive prostatic calculi with highlight of stones found in a unique paraprostatic urethral diverticulum. ( 28779694 )
2017
20
A complicated urethrovaginal fistula following an inappropriate urethral diverticulum management. ( 28805613 )
2017
21
Urethral Diverticulum Presenting as a Large Vaginal Mass Complicating Pregnancy and Delivery. ( 29026065 )
2017
22
The Prostate in Female? Clear Cell Adenocarcinoma in a Female Urethral Diverticulum. ( 27789300 )
2017
23
Urethral diverticulum and urolithiasis in a female guinea pig (Cavia porcellus). ( 29154708 )
2017
24
Calculus in female urethral diverticulum eroded to the vagina. ( 28283712 )
2017
25
Role of urodynamics in management of urethral diverticulum in females. ( 28807625 )
2017
26
Nephrogenic adenoma arising in a complex circumferential urethral diverticulum of a female patient with a history of childhood neuroblastoma and chemotherapy. ( 27324755 )
2016
27
Urethral Diverticulum in Women: Retrospective Case Series. ( 26924907 )
2016
28
Male urethral diverticulum uncommon entity: Our experience. ( 28057997 )
2016
29
Acute Urinary Retention in a Female Following Bladder Tumor Resection Due To a Stone in a Urethral Diverticulum. ( 27085569 )
2016
30
Congenital urethral diverticulum with infertility in an adult man and review of the literature. ( 27822441 )
2016
31
Anterior urethral diverticulum: A rare presentation. ( 27833294 )
2016
32
Preoperative 3D and 4D-CT imaging using 640-Multislice CT (640-MSCT) in diagnosis of female urethral diverticulum. ( 27803968 )
2016
33
Female urethral diverticulum containing a urothelial carcinoma. ( 28057968 )
2016
34
Congenital anterior urethral diverticulum presenting as a scrotal mass in a two-year-old child. ( 28096926 )
2016
35
Acquired male urethral diverticulum: a rare entity treated in a one-stage procedure. ( 27895077 )
2016
36
Female Urethral Diverticulum: Presentation, Diagnosis, and Predictors of Outcomes After Surgery. ( 27636213 )
2016
37
Surgical treatment of an acquired posterior urethral diverticulum with cystoscopy assisted robotic technique. ( 27440231 )
2016
38
Long-term outcomes after the excision of horseshoe urethral diverticulum. ( 26670574 )
2016
39
Excision of urethral diverticulum in a 24 year old woman. ( 25624583 )
2015
40
Minimally invasive surgical approach to treat posterior urethral diverticulum. ( 25834967 )
2015
41
Urethral diverticulum: a potential hazard of penile clamp application for male urinary incontinence. ( 25858949 )
2015
42
Primary squamous cell carcinoma of the urethral diverticulum mimicking prostate cancer: Case report and review of the literature. ( 26029309 )
2015
43
Female Urethral Diverticulum: Current Diagnosis and Management. ( 26267225 )
2015
44
Urethral Diverticulum Masquerading as Anterior Vaginal Wall Cyst: A Diagnostic Dilemma. ( 26557574 )
2015
45
Congenital anterior urethral diverticulum: A case report. ( 26628815 )
2015
46
Female urethral diverticulum containing a giant calculus: a CARE-compliant case report. ( 25997056 )
2015
47
Urethral diverticulum in the female: a meta-analysis of modern series. ( 26545036 )
2015
48
Congenital anterior urethral diverticulum: antenatal diagnosis with subsequent neonatal endoscopic management. ( 25704997 )
2015
49
Congenital anterior urethral diverticulum. ( 26328174 )
2014
50
Simple vs complex urethral diverticulum: presentation and outcomes. ( 25432847 )
2014

Variations for Urethral Diverticulum

Expression for Urethral Diverticulum

Search GEO for disease gene expression data for Urethral Diverticulum.

Pathways for Urethral Diverticulum

Pathways related to Urethral Diverticulum according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.89 F3 KLK3 PVR
2
Show member pathways
10.62 KLK3 NKX3-1

GO Terms for Urethral Diverticulum

Biological processes related to Urethral Diverticulum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.43 PAX8 UPK3A WT1
2 branching involved in ureteric bud morphogenesis GO:0001658 9.4 PAX8 WT1
3 metanephros development GO:0001656 9.37 NKX3-1 PAX8
4 urogenital system development GO:0001655 9.32 NKX3-1 PAX8
5 cellular response to gonadotropin stimulus GO:0071371 9.16 PAX8 WT1
6 metanephric epithelium development GO:0072207 8.96 PAX8 WT1
7 metanephric S-shaped body morphogenesis GO:0072284 8.62 PAX8 WT1

Molecular functions related to Urethral Diverticulum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region DNA binding GO:0044212 8.8 NKX3-1 PAX8 WT1

Sources for Urethral Diverticulum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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