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MCID: URT016
MIFTS: 37

Urethral Diverticulum

Categories: Nephrological diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Urethral Diverticulum

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MalaCards integrated aliases for Urethral Diverticulum:

Name: Urethral Diverticulum 12 15 73

Classifications:

MalaCards categories:
Anatomical: Nephrological diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:9341
ICD10 33 N36.1
ICD9CM 35 599.2
NCIt 50 C39861
SNOMED-CT 68 90531003
UMLS 73 C0152443
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Summaries for Urethral Diverticulum

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MalaCards based summary : Urethral Diverticulum is related to clear cell adenocarcinoma and nephrogenic adenoma. An important gene associated with Urethral Diverticulum is KIDINS220 (Kinase D Interacting Substrate 220), and among its related pathways/superpathways is Adhesion. The drugs Sulfamethoxazole and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include prostate, testes and skin, and related phenotypes are cellular and homeostasis/metabolism

Wikipedia : 76 A urethral diverticulum is a condition where the urethra or the periurethral glands push into the... more...

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Related Diseases for Urethral Diverticulum

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Diseases related to Urethral Diverticulum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 clear cell adenocarcinoma 30.5 AMACR KLK3 KRT7
2 nephrogenic adenoma 30.1 AMACR KLK3 KRT7 PAX8
3 urethritis 11.0
4 prostate sarcoma 10.7 KLK3 NKX3-1
5 renal pelvis transitional cell carcinoma 10.6 KRT7 UPK3A
6 glandular cystitis 10.6 KRT7 UPK3A
7 congenital bile acid synthesis defect 10.6 AMACR PVR
8 rectal disease 10.6 KIDINS220 KLK3
9 ovarian benign neoplasm 10.6 KRT7 UPK3A
10 prostatic acinar adenocarcinoma 10.6 AMACR KLK3
11 vulval paget's disease 10.6 KRT7 UPK3A
12 nephrogenic adenoma of urinary bladder 10.6 KRT7 PAX8
13 chronic cystitis 10.6 KRT7 UPK3A
14 bladder benign neoplasm 10.6 KRT7 PAX8
15 vulva adenocarcinoma 10.6 KRT7 UPK3A
16 clear cell papillary renal cell carcinoma 10.5 AMACR KRT7
17 lymphocele 10.5 KLK3 PKDREJ
18 renal pelvis adenocarcinoma 10.5 KRT7 PAX8
19 ovarian mucinous adenocarcinoma 10.5 AMACR KRT7
20 endocervical carcinoma 10.5 KRT7 PAX8
21 radiation cystitis 10.5 KLK3 UPK3A
22 urethral syndrome 10.5 KIDINS220 KLK3
23 rete testis neoplasm 10.5 KLK3 PAX8
24 seminal vesicle adenocarcinoma 10.4 KLK3 KRT7
25 adenocarcinoma 10.4
26 endocervical adenocarcinoma 10.4 KRT7 PAX8
27 peritoneum cancer 10.4 PAX8 WT1
28 urethral benign neoplasm 10.4 AMACR KLK3 UPK3A
29 suppression of tumorigenicity 12 10.3 AMACR KLK3 NKX3-1
30 seminal vesicle tumor 10.3 KLK3 KRT7
31 male reproductive organ cancer 10.3 AMACR KLK3 NKX3-1
32 renal pelvis carcinoma 10.3 KRT7 PAX8 UPK3A
33 vaginitis 10.3
34 adenocarcinoma in situ 10.3 KRT7 PAX8
35 female reproductive endometrioid cancer 10.3 KRT7 WT1
36 adenoma 10.3
37 prostate squamous cell carcinoma 10.3 KLK3 KRT7
38 kidney benign neoplasm 10.3 AMACR KRT7 PAX8
39 nodular hidradenoma 10.3 FUT4 KRT7
40 ovarian cystic teratoma 10.3 KRT7 PVR
41 collecting duct carcinoma 10.3 AMACR KRT7 PAX8
42 adenomatoid tumor 10.2 KRT7 WT1
43 endodermal sinus tumor 10.2 KLK3 KRT7
44 vulva cancer 10.2 KRT7 UPK3A
45 sertoli-leydig cell tumor 10.2 KRT7 WT1
46 infiltrative basal cell carcinoma 10.1 FUT4 KRT7
47 prostatitis 10.1
48 bladder neck obstruction 10.1 F3 KLK3
49 bladder urothelial carcinoma 10.1 KLK3 KRT7 UPK3A
50 ovarian mucinous neoplasm 10.1 KRT7 WT1

Comorbidity relations with Urethral Diverticulum via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Urethral Diverticulum:



Diseases related to Urethral Diverticulum
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Symptoms & Phenotypes for Urethral Diverticulum

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MGI Mouse Phenotypes related to Urethral Diverticulum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.81 KIDINS220 KRT7 MCU NKX3-1 PAX8 WT1
2 homeostasis/metabolism MP:0005376 9.65 HGD KRT7 MCU NKX3-1 PAX8 UPK3A
3 renal/urinary system MP:0005367 9.1 HGD KRT7 PAX8 UPK3A WT1 CTSB
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Drugs & Therapeutics for Urethral Diverticulum

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Drugs for Urethral Diverticulum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sulfamethoxazole Approved Not Applicable 723-46-6 5329
2
Trimethoprim Approved, Vet_approved Not Applicable 738-70-5 5578
3
leucovorin Approved, Nutraceutical Not Applicable 58-05-9 143 6006
4
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
5 Renal Agents Not Applicable
6 Folic Acid Antagonists Not Applicable
7 Cytochrome P-450 Enzyme Inhibitors Not Applicable
8 Trimethoprim, Sulfamethoxazole Drug Combination Not Applicable
9 Anti-Bacterial Agents Not Applicable
10 Vitamin B Complex Not Applicable
11 Antibiotics, Antitubercular Not Applicable
12 Anti-Infective Agents Not Applicable
13 Antiparasitic Agents Not Applicable
14 Antiprotozoal Agents Not Applicable
15 Antimalarials Not Applicable
16 Folate Nutraceutical Not Applicable
17 Vitamin B9 Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Primary Urethral Realignment Versus Suprapubic Cystostomy After Pelvic Fracture Urethral Injury Recruiting NCT03195179
2 Prophylactic Antibiotics or Placebo After Hypospadias Repair Active, not recruiting NCT02096159 Not Applicable trimethoprim-sulfamethoxazole

Search NIH Clinical Center for Urethral Diverticulum

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Genetic Tests for Urethral Diverticulum

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Anatomical Context for Urethral Diverticulum

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MalaCards organs/tissues related to Urethral Diverticulum:

41
Prostate, Testes, Skin, Kidney, Colon
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Publications for Urethral Diverticulum

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Articles related to Urethral Diverticulum:

(show top 50) (show all 315)
# Title Authors Year
1
Female urethral diverticulum containing large calculi. ( 29686963 )
2018
2
Surgical correction of urethral diverticulum in a female pseudo-hermaphrodite crossbred calf. ( 29805465 )
2018
3
Suspected congenital urethral diverticulum in a dog. ( 29599553 )
2018
4
Incidental Finding of Urethral Diverticulum in a Woman with History of Recurrent Urinary Tract Infections. ( 29692697 )
2018
5
Diagnosis of urethral diverticulum mimicking pelvic organ prolapse with translabial ultrasonography. ( 28666694 )
2017
6
Preliminary report on the effect of urethral diverticulum magnetic resonance imaging configuration on the incidence of new onset urodynamic stress urinary incontinence following excision. ( 29118531 )
2017
7
Female Urethral Diverticulum Carcinoma: A Case Report and Literature Review. ( 28630778 )
2017
8
Anastomotic Urethroplasty for an Obstructing Calculus Within a Bulbar Urethral Diverticulum and Urethral Stricture. ( 27981035 )
2017
9
A rare presentation of alkaptonuria: Extensive prostatic calculi with highlight of stones found in a unique paraprostatic urethral diverticulum. ( 28779694 )
2017
10
A complicated urethrovaginal fistula following an inappropriate urethral diverticulum management. ( 28805613 )
2017
11
Urethral Diverticulum Presenting as a Large Vaginal Mass Complicating Pregnancy and Delivery. ( 29026065 )
2017
12
The Prostate in Female? Clear Cell Adenocarcinoma in a Female Urethral Diverticulum. ( 27789300 )
2017
13
Urethral diverticulum and urolithiasis in a female guinea pig (Cavia porcellus). ( 29154708 )
2017
14
Calculus in female urethral diverticulum eroded to the vagina. ( 28283712 )
2017
15
Role of urodynamics in management of urethral diverticulum in females. ( 28807625 )
2017
16
Nephrogenic adenoma arising in a complex circumferential urethral diverticulum of a female patient with a history of childhood neuroblastoma and chemotherapy. ( 27324755 )
2016
17
Urethral Diverticulum in Women: Retrospective Case Series. ( 26924907 )
2016
18
Male urethral diverticulum uncommon entity: Our experience. ( 28057997 )
2016
19
Acute Urinary Retention in a Female Following Bladder Tumor Resection Due To a Stone in a Urethral Diverticulum. ( 27085569 )
2016
20
Congenital urethral diverticulum with infertility in an adult man and review of the literature. ( 27822441 )
2016
21
Anterior urethral diverticulum: A rare presentation. ( 27833294 )
2016
22
Preoperative 3D and 4D-CT imaging using 640-Multislice CT (640-MSCT) in diagnosis of female urethral diverticulum. ( 27803968 )
2016
23
Female urethral diverticulum containing a urothelial carcinoma. ( 28057968 )
2016
24
Congenital anterior urethral diverticulum presenting as a scrotal mass in a two-year-old child. ( 28096926 )
2016
25
Acquired male urethral diverticulum: a rare entity treated in a one-stage procedure. ( 27895077 )
2016
26
Female Urethral Diverticulum: Presentation, Diagnosis, and Predictors of Outcomes After Surgery. ( 27636213 )
2016
27
Surgical treatment of an acquired posterior urethral diverticulum with cystoscopy assisted robotic technique. ( 27440231 )
2016
28
Long-term outcomes after the excision of horseshoe urethral diverticulum. ( 26670574 )
2016
29
Excision of urethral diverticulum in a 24 year old woman. ( 25624583 )
2015
30
Minimally invasive surgical approach to treat posterior urethral diverticulum. ( 25834967 )
2015
31
Urethral diverticulum: a potential hazard of penile clamp application for male urinary incontinence. ( 25858949 )
2015
32
Primary squamous cell carcinoma of the urethral diverticulum mimicking prostate cancer: Case report and review of the literature. ( 26029309 )
2015
33
Female Urethral Diverticulum: Current Diagnosis and Management. ( 26267225 )
2015
34
Urethral Diverticulum Masquerading as Anterior Vaginal Wall Cyst: A Diagnostic Dilemma. ( 26557574 )
2015
35
Congenital anterior urethral diverticulum: A case report. ( 26628815 )
2015
36
Female urethral diverticulum containing a giant calculus: a CARE-compliant case report. ( 25997056 )
2015
37
Urethral diverticulum in the female: a meta-analysis of modern series. ( 26545036 )
2015
38
Congenital anterior urethral diverticulum: antenatal diagnosis with subsequent neonatal endoscopic management. ( 25704997 )
2015
39
Congenital anterior urethral diverticulum. ( 26328174 )
2014
40
Simple vs complex urethral diverticulum: presentation and outcomes. ( 25432847 )
2014
41
Scrotal pop off in a congenital anterior urethral diverticulum. ( 24928476 )
2014
42
Nephrogenic adenoma in a urethral diverticulum. ( 25185615 )
2014
43
Urethral Diverticulum After Midurethral Sling Erosion, Excision, and Subsequent Management. ( 25185624 )
2014
44
Management of Infected Urethral Diverticulum With Urethral Dilation. ( 25185607 )
2014
45
Urinary retention in an infant caused by a posterior urethral diverticulum lithiasis following surgery for anorectal malformation. ( 24493407 )
2014
46
Male urethral diverticulum having multiple stones. ( 25031909 )
2014
47
Congenital duplication of the urethra with urethral diverticulum: a case report. ( 25254101 )
2014
48
Congenital giant male anterior urethral diverticulum with calculi. ( 24567184 )
2014
49
Preoperative CT voiding cystourethrography using 16-multidetector CT in female urethral diverticulum. ( 25216189 )
2014
50
Urethral diverticulum misdiagnosed with cystocele. ( 24694057 )
2014
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Variations for Urethral Diverticulum

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Expression for Urethral Diverticulum

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Search GEO for disease gene expression data for Urethral Diverticulum.
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Pathways for Urethral Diverticulum

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Pathways related to Urethral Diverticulum according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Adhesion 4
10.89 F3 KLK3 PVR
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GO Terms for Urethral Diverticulum

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Biological processes related to Urethral Diverticulum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.54 PAX8 UPK3A WT1
2 epithelial cell differentiation GO:0030855 9.43 CTSB UPK3A WT1
3 metanephros development GO:0001656 9.4 NKX3-1 PAX8
4 urogenital system development GO:0001655 9.32 NKX3-1 PAX8
5 cellular response to gonadotropin stimulus GO:0071371 9.16 PAX8 WT1
6 metanephric S-shaped body morphogenesis GO:0072284 8.96 PAX8 WT1
7 metanephric epithelium development GO:0072207 8.62 PAX8 WT1
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Sources for Urethral Diverticulum

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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