MCID: URT016
MIFTS: 37

Urethral Diverticulum

Categories: Nephrological diseases

Aliases & Classifications for Urethral Diverticulum

MalaCards integrated aliases for Urethral Diverticulum:

Name: Urethral Diverticulum 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:9341
ICD9CM 36 599.2
NCIt 51 C39861
SNOMED-CT 69 90531003
ICD10 34 N36.1
UMLS 74 C0152443

Summaries for Urethral Diverticulum

MalaCards based summary : Urethral Diverticulum is related to transitional cell carcinoma and clear cell adenocarcinoma. An important gene associated with Urethral Diverticulum is KIDINS220 (Kinase D Interacting Substrate 220), and among its related pathways/superpathways are Pathways in cancer and Adhesion. The drugs Sulfamethoxazole and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and kidney, and related phenotypes are cellular and homeostasis/metabolism

Wikipedia : 77 A urethral diverticulum is a condition where the urethra or the periurethral glands push into the... more...

Related Diseases for Urethral Diverticulum

Diseases related to Urethral Diverticulum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
# Related Disease Score Top Affiliating Genes
1 transitional cell carcinoma 30.4 CDKN2A KRT7 UPK3A
2 clear cell adenocarcinoma 30.4 AMACR KLK3 KRT7 PAX8
3 nephrogenic adenoma 30.2 AMACR KLK3 KRT7 NKX3-1 PAX8
4 acute cystitis 29.8 KLK3 MCU
5 adenocarcinoma 10.6
6 adenoma 10.4
7 renal pelvis transitional cell carcinoma 10.4 KRT7 UPK3A
8 prostate sarcoma 10.3 KLK3 NKX3-1
9 glandular cystitis 10.3 KRT7 UPK3A
10 chronic cystitis 10.3 KRT7 UPK3A
11 nephrogenic adenoma of urinary bladder 10.3 KRT7 PAX8
12 bladder benign neoplasm 10.3 KRT7 PAX8
13 clear cell papillary renal cell carcinoma 10.3 AMACR KRT7
14 papillary adenoma 10.3 AMACR KRT7
15 renal pelvis adenocarcinoma 10.3 KRT7 PAX8
16 sensory organ benign neoplasm 10.3 KRT7 PAX8
17 inverted transitional papilloma 10.3 CDKN2A KRT7
18 prostate small cell carcinoma 10.3 AMACR KLK3
19 ovarian mucinous adenocarcinoma 10.3 AMACR KRT7
20 fallopian tube squamous cell carcinoma 10.3 CDKN2A WT1
21 adenoid basal cell carcinoma 10.3 CDKN2A KRT7
22 seminal vesicle adenocarcinoma 10.3 KLK3 KRT7
23 bile duct adenoma 10.3 CDKN2A KRT7
24 bladder carcinoma in situ 10.3 CDKN2A KRT7
25 nasal cavity cancer 10.3 CDKN2A KRT7
26 nasal cavity adenocarcinoma 10.3 CDKN2A KRT7
27 rete testis neoplasm 10.2 KLK3 PAX8
28 anal canal carcinoma 10.2 CDKN2A KRT7
29 glycogen-rich clear cell breast carcinoma 10.2 CDKN2A KRT7
30 melanomatosis 10.2 CDKN2A WT1
31 seminal vesicle tumor 10.2 KLK3 KRT7
32 mucinous bronchioloalveolar adenocarcinoma 10.2 CDKN2A KRT7
33 well-differentiated liposarcoma 10.2 CDKN2A KRT7
34 sarcomatoid mesothelioma 10.2 CDKN2A WT1
35 urethra adenocarcinoma 10.2 AMACR KLK3 UPK3A
36 prostate squamous cell carcinoma 10.2 KLK3 KRT7
37 urethra clear cell adenocarcinoma 10.2 AMACR KLK3 UPK3A
38 benign mesothelioma 10.2 KRT7 WT1
39 ovarian cystic teratoma 10.2 KRT7 PVR
40 urethral benign neoplasm 10.2 AMACR KLK3 UPK3A
41 male reproductive organ benign neoplasm 10.2 KLK3 WT1
42 radiation cystitis 10.2 KLK3 UPK3A
43 squamous cell carcinoma 10.2
44 nasal cavity squamous cell carcinoma 10.2 CDKN2A KRT7
45 urethral syndrome 10.2 KIDINS220 KLK3
46 anus disease 10.2 CDKN2A KIDINS220
47 breast giant fibroadenoma 10.2 CDKN2A WT1
48 necrotizing sialometaplasia 10.2 CDKN2A KRT7
49 female reproductive endometrioid cancer 10.2 KRT7 WT1
50 rectal disease 10.2 CDKN2A KIDINS220 KLK3

Comorbidity relations with Urethral Diverticulum via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Urethral Diverticulum:



Diseases related to Urethral Diverticulum

Symptoms & Phenotypes for Urethral Diverticulum

MGI Mouse Phenotypes related to Urethral Diverticulum:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.61 CDKN2A F3 FUT4 KIDINS220 KRT7 MCU
2 homeostasis/metabolism MP:0005376 9.32 AMACR CDKN2A F3 HGD KRT7 MCU

Drugs & Therapeutics for Urethral Diverticulum

Drugs for Urethral Diverticulum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sulfamethoxazole Approved Not Applicable 723-46-6 5329
2
Trimethoprim Approved, Vet_approved Not Applicable 738-70-5 5578
3
leucovorin Approved Not Applicable 58-05-9 6006 143
4
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
5 Cytochrome P-450 Enzyme Inhibitors Not Applicable
6 Anti-Bacterial Agents Not Applicable
7 Vitamin B Complex Not Applicable
8 Anti-Infective Agents Not Applicable
9 Trimethoprim, Sulfamethoxazole Drug Combination Not Applicable
10 Antimalarials Not Applicable
11 Antiparasitic Agents Not Applicable
12 Antibiotics, Antitubercular Not Applicable
13 Anti-Infective Agents, Urinary Not Applicable
14 Vitamin B9 Not Applicable
15 Folate Not Applicable
16 Antiprotozoal Agents Not Applicable
17 Folic Acid Antagonists Not Applicable
18 Renal Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Primary Urethral Realignment Versus Suprapubic Cystostomy After Pelvic Fracture Urethral Injury Recruiting NCT03195179
2 Prophylactic Antibiotics or Placebo After Hypospadias Repair Active, not recruiting NCT02096159 Not Applicable trimethoprim-sulfamethoxazole

Search NIH Clinical Center for Urethral Diverticulum

Genetic Tests for Urethral Diverticulum

Anatomical Context for Urethral Diverticulum

MalaCards organs/tissues related to Urethral Diverticulum:

42
Testes, Skin, Kidney, Colon

Publications for Urethral Diverticulum

Articles related to Urethral Diverticulum:

(show top 50) (show all 338)
# Title Authors Year
1
Primary Small Cell Neuroendocrine Tumor Within a Urethral Diverticulum. ( 30633138 )
2019
2
Post void incontinence secondary to female urethral diverticulum. ( 30741660 )
2019
3
Urethral diverticulum in pregnancy: a case report. ( 30879101 )
2019
4
Female urethral diverticulum containing large calculi. ( 29686963 )
2018
5
Surgical correction of urethral diverticulum in a female pseudo-hermaphrodite crossbred calf. ( 29805465 )
2018
6
Suspected congenital urethral diverticulum in a dog. ( 29599553 )
2018
7
Incidental Finding of Urethral Diverticulum in a Woman with History of Recurrent Urinary Tract Infections. ( 29692697 )
2018
8
Urethral diverticulum repair using diverticulum wall: A new technique for preparing covering flap layer. ( 29998061 )
2018
9
Rare cause of voiding dysfunction in an adult man: urethral diverticulum compressing the anterior urethra. ( 30012683 )
2018
10
Managing female urethral diverticulum with a standardized technique using a pacifier-trick artifice to facilitate dissection. ( 30178127 )
2018
11
Enterolithiasis in posterior urethral diverticulum: an uncommon complication following surgery for anorectal malformation. ( 30209147 )
2018
12
Urethral diverticulum carcinoma in females-a case series and review of the English and Japanese literature. ( 30211061 )
2018
13
Periurethral Abscess Complicating Urethral Diverticulum. ( 30253950 )
2018
14
Female urethral diverticulum containing calculi: A rare and tricky condition. ( 30263891 )
2018
15
Correlation of MRI features of urethral diverticulum and pre- and post-operative stress urinary incontinence. ( 30411812 )
2018
16
Giant urethral diverticulum calculus revealed by peri-urethral abscess. ( 30430479 )
2018
17
A Case of Urethral Diverticulum with Surgical Repair Using Cadaveric Pericardial Tissue. ( 30519496 )
2018
18
Diagnosis of urethral diverticulum mimicking pelvic organ prolapse with translabial ultrasonography. ( 28666694 )
2017
19
Preliminary report on the effect of urethral diverticulum magnetic resonance imaging configuration on the incidence of new onset urodynamic stress urinary incontinence following excision. ( 29118531 )
2017
20
Female Urethral Diverticulum Carcinoma: A Case Report and Literature Review. ( 28630778 )
2017
21
Anastomotic Urethroplasty for an Obstructing Calculus Within a Bulbar Urethral Diverticulum and Urethral Stricture. ( 27981035 )
2017
22
A rare presentation of alkaptonuria: Extensive prostatic calculi with highlight of stones found in a unique paraprostatic urethral diverticulum. ( 28779694 )
2017
23
A complicated urethrovaginal fistula following an inappropriate urethral diverticulum management. ( 28805613 )
2017
24
Urethral Diverticulum Presenting as a Large Vaginal Mass Complicating Pregnancy and Delivery. ( 29026065 )
2017
25
The Prostate in Female? Clear Cell Adenocarcinoma in a Female Urethral Diverticulum. ( 27789300 )
2017
26
Urethral diverticulum and urolithiasis in a female guinea pig (Cavia porcellus). ( 29154708 )
2017
27
Calculus in female urethral diverticulum eroded to the vagina. ( 28283712 )
2017
28
Role of urodynamics in management of urethral diverticulum in females. ( 28807625 )
2017
29
Nephrogenic adenoma arising in a complex circumferential urethral diverticulum of a female patient with a history of childhood neuroblastoma and chemotherapy. ( 27324755 )
2016
30
Urethral Diverticulum in Women: Retrospective Case Series. ( 26924907 )
2016
31
Male urethral diverticulum uncommon entity: Our experience. ( 28057997 )
2016
32
Acute Urinary Retention in a Female Following Bladder Tumor Resection Due To a Stone in a Urethral Diverticulum. ( 27085569 )
2016
33
Congenital urethral diverticulum with infertility in an adult man and review of the literature. ( 27822441 )
2016
34
Anterior urethral diverticulum: A rare presentation. ( 27833294 )
2016
35
Preoperative 3D and 4D-CT imaging using 640-Multislice CT (640-MSCT) in diagnosis of female urethral diverticulum. ( 27803968 )
2016
36
Female urethral diverticulum containing a urothelial carcinoma. ( 28057968 )
2016
37
Congenital anterior urethral diverticulum presenting as a scrotal mass in a two-year-old child. ( 28096926 )
2016
38
Acquired male urethral diverticulum: a rare entity treated in a one-stage procedure. ( 27895077 )
2016
39
Female Urethral Diverticulum: Presentation, Diagnosis, and Predictors of Outcomes After Surgery. ( 27636213 )
2016
40
Surgical treatment of an acquired posterior urethral diverticulum with cystoscopy assisted robotic technique. ( 27440231 )
2016
41
Long-term outcomes after the excision of horseshoe urethral diverticulum. ( 26670574 )
2016
42
Excision of urethral diverticulum in a 24 year old woman. ( 25624583 )
2015
43
Minimally invasive surgical approach to treat posterior urethral diverticulum. ( 25834967 )
2015
44
Urethral diverticulum: a potential hazard of penile clamp application for male urinary incontinence. ( 25858949 )
2015
45
Primary squamous cell carcinoma of the urethral diverticulum mimicking prostate cancer: Case report and review of the literature. ( 26029309 )
2015
46
Female Urethral Diverticulum: Current Diagnosis and Management. ( 26267225 )
2015
47
Urethral Diverticulum Masquerading as Anterior Vaginal Wall Cyst: A Diagnostic Dilemma. ( 26557574 )
2015
48
Congenital anterior urethral diverticulum: A case report. ( 26628815 )
2015
49
Female urethral diverticulum containing a giant calculus: a CARE-compliant case report. ( 25997056 )
2015
50
Urethral diverticulum in the female: a meta-analysis of modern series. ( 26545036 )
2015

Variations for Urethral Diverticulum

Expression for Urethral Diverticulum

Search GEO for disease gene expression data for Urethral Diverticulum.

Pathways for Urethral Diverticulum

Pathways related to Urethral Diverticulum according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.98 CDKN2A KLK3 NKX3-1 PAX8
2 10.89 F3 KLK3 PVR

GO Terms for Urethral Diverticulum

Biological processes related to Urethral Diverticulum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.5 PAX8 UPK3A WT1
2 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.43 CDKN2A F3 NKX3-1
3 metanephros development GO:0001656 9.4 NKX3-1 PAX8
4 urogenital system development GO:0001655 9.37 NKX3-1 PAX8
5 cellular response to gonadotropin stimulus GO:0071371 9.16 PAX8 WT1
6 metanephric epithelium development GO:0072207 8.96 PAX8 WT1
7 metanephric S-shaped body morphogenesis GO:0072284 8.62 PAX8 WT1

Sources for Urethral Diverticulum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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