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MCID: URT037
MIFTS: 42

Urethral Stricture

Categories: Nephrological diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Urethral Stricture

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MalaCards integrated aliases for Urethral Stricture:

Name: Urethral Stricture 12 54 6 15 70 32

Classifications:

MalaCards categories:
Anatomical: Nephrological diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1829
ICD9CM 34 598.8
ICD10 32 N35 N35.9
UMLS 70 C0029752 C0041974
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Summaries for Urethral Stricture

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MalaCards based summary : Urethral Stricture is related to sexual disorder and prostatic hyperplasia, benign. An important gene associated with Urethral Stricture is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways is Adhesion. The drugs Lidocaine and Diclofenac have been mentioned in the context of this disorder. Affiliated tissues include prostate, skin and kidney.

Wikipedia : 73 A urethral stricture is a narrowing of the urethra caused by injury, instrumentation, infection, and... more...

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Related Diseases for Urethral Stricture

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Diseases related to Urethral Stricture via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
# Related Disease Score Top Affiliating Genes
1 sexual disorder 30.7 PDE5A KLK3
2 prostatic hyperplasia, benign 30.7 PDE5A KLK3 FOLH1
3 urinary tract obstruction 30.5 TGFB1 KLK3 CCN2
4 urethral calculus 30.5 MCU KLK3
5 urethral diverticulum 30.4 MCU LINC00538 KLK3
6 prostatitis 30.4 TGFB1 PDE5A KLK3
7 renal fibrosis 30.0 TGFB1 MIR21 CCN2
8 ischemia 29.4 PDE5A MIR21 MCU
9 urethral syndrome 11.2
10 infective urethral stricture 11.2
11 hypospadias 10.7
12 lichen sclerosus et atrophicus 10.7
13 impotence 10.6
14 urinary tract infection 10.6
15 urethritis 10.5
16 prostatic hypertrophy 10.5
17 prostatic adenoma 10.4
18 acute cystitis 10.4
19 cystitis 10.3
20 female stress incontinence 10.3 PDE5A KLK3
21 balanitis 10.3
22 balanitis xerotica obliterans 10.3
23 leukoplakia of penis 10.3
24 bladder neck obstruction 10.3 PDE5A KLK3
25 mandibular cancer 10.2 KLK3 CCN2
26 lower urinary tract calculus 10.2 MCU KLK3
27 peyronie disease 10.2 TGFB1 PDE5A
28 cholecystolithiasis 10.2 TGFB1 CCN2
29 prostate cancer 10.2
30 hydronephrosis 10.2
31 orchitis 10.2
32 epididymo-orchitis 10.2
33 urethral cancer 10.2
34 diffuse scleroderma 10.2 TGFB1 CCN2
35 nephrogenic systemic fibrosis 10.2 TGFB1 CCN2
36 ocular cicatricial pemphigoid 10.2 TGFB1 CCN2
37 stiff skin syndrome 10.2 TGFB1 CCN2
38 trachoma 10.2 TGFB1 CCN2
39 lymphocele 10.2 KLK3 FOLH1
40 prostate neuroendocrine neoplasm 10.2 KLK3 FOLH1
41 nonspecific interstitial pneumonia 10.2 TGFB1 MIR21
42 bladder lateral wall cancer 10.2 KLK3 FOLH1
43 bacteriuria 10.1
44 kidney disease 10.1
45 urethral gland abscess 10.1
46 penile disease 10.1 TGFB1 PDE5A
47 epithelial basement membrane dystrophy 10.1 TGFB1 PLEC
48 breast cyst 10.1 TGFB1 KLK3
49 microvascular complications of diabetes 3 10.1 TGFB1 MIR21 CCN2
50 villous adenoma 10.1 KLK3 FOLH1

Comorbidity relations with Urethral Stricture via Phenotypic Disease Network (PDN): (show all 25)


Acute Cystitis Acute Kidney Failure
Balanoposthitis Bladder Cancer
Bladder Neck Obstruction Chronic Kidney Disease
Cystitis Cystitis Cystica
Deficiency Anemia Epididymo-Orchitis
Hydronephrosis Nephrolithiasis, X-Linked Recessive, with Renal Failure
Neurogenic Bladder Peyronie's Disease
Prostate Calculus Prostate Cancer
Prostatic Hypertrophy Prostatitis
Radiation Cystitis Trigonitis
Ureterolithiasis Urethral Calculus
Urethral Gland Abscess Urethritis
Urinary Tract Obstruction

Graphical network of the top 20 diseases related to Urethral Stricture:



Diseases related to Urethral Stricture
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Symptoms & Phenotypes for Urethral Stricture

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Drugs & Therapeutics for Urethral Stricture

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Drugs for Urethral Stricture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
2
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
3
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
4
Acetaminophen Approved Phase 4 103-90-2 1983
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
6
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
7
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
8
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
9
Ibuprofen Approved Phase 4 15687-27-1 3672
10
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
11 Neurotransmitter Agents Phase 4
12 Anesthetics, Local Phase 4
13 Gastrointestinal Agents Phase 4
14 Psychotropic Drugs Phase 4
15 Antirheumatic Agents Phase 4
16 Antiemetics Phase 4
17 Hormones Phase 4
18 Narcotics Phase 4
19 Excitatory Amino Acid Antagonists Phase 4
20 Anti-Inflammatory Agents Phase 4
21 Anti-Anxiety Agents Phase 4
22 Hormone Antagonists Phase 4
23 Analgesics Phase 4
24 Anticonvulsants Phase 4
25 Cyclooxygenase Inhibitors Phase 4
26 glucocorticoids Phase 4
27 Analgesics, Opioid Phase 4
28 Antineoplastic Agents, Hormonal Phase 4
29 Cyclooxygenase 2 Inhibitors Phase 4
30 BB 1101 Phase 4
31 Antipyretics Phase 4
32 Anti-Inflammatory Agents, Non-Steroidal Phase 4
33 Analgesics, Non-Narcotic Phase 4
34
Silicon Approved, Investigational Phase 2, Phase 3 7440-21-3 4082203
35 Pharmaceutical Solutions Phase 3
36 Antibiotics, Antitubercular Phase 1, Phase 2
37 Alkylating Agents Phase 1, Phase 2
38 Mitomycins Phase 1, Phase 2
39 Anti-Bacterial Agents Phase 1, Phase 2
40 Anesthetics Phase 2
41 Fibrin Tissue Adhesive Phase 1
42
Epinephrine Approved, Vet_approved 51-43-4 5816
43
Racepinephrine Approved 329-65-7 838
44 Adrenergic alpha-Agonists
45 Respiratory System Agents
46 Anti-Asthmatic Agents
47 Adrenergic beta-Agonists
48 Epinephryl borate
49 Adrenergic Agonists
50 Vasoconstrictor Agents

Interventional clinical trials:

(show all 33)
# Name Status NCT ID Phase Drugs
1 Cold vs. Laser Internal Urethrotomy Treatment of Urethral Strictures Unknown status NCT01196572 Phase 4
2 The Effect of Preemptive Analgesia On The Comfort Of Patient and Doctor, in Cystoscopy Unknown status NCT03831321 Phase 4 Diclofenac Sodium;Lubricant Gel
3 Efficacy of Opioid-limiting Pain Management Protocol in Men Undergoing Urethroplasty Recruiting NCT03859024 Phase 4 Oxycodone;Acetaminophen;Gabapentin;celebrex;Bupivacaine;Ibuprofen 800 mg;Dexamethasone
4 Liposomal Bupivacaine To Control Post-Operative Pain Following Buccal Mucosal Graft Harvesting Unknown status NCT03720223 Phase 3 Liposomal Bupivacaine
5 Diagnosis of Urethral Stricture With Sono-urethrography vs Conventional Urethrography: Evaluation of the Diagnostic Value and Evaluation of the Reduction of the Radiation Dose With Sono-urethrography (SONO-URETHRA) Unknown status NCT01790776 Phase 3
6 Prospective, Randomized, Controlled, Multicenter Trial of the Memokath® 044TW Thermo-Expandable Stent for Maintaining Urethral Patency in Patients After Dilation or Internal Urethrotomy of Recurrent Stricture of the Bulbar Urethra Completed NCT00270504 Phase 3
7 Holmium: YAG Versus Cold Knife Internal Urethrotomy in Management of Short Urethral Strictures: A Randomized Controlled Trial Completed NCT04650347 Phase 2, Phase 3
8 PASTIS-Trial: Pre-operative Assessment by Sonourethrography Only in Anterior Urethral Strictures: A Prospective Feasibility Trial Not yet recruiting NCT04452890 Phase 3
9 Effect of Mitomycin C on Urethral Stricture Recurrence After Internal Urethrotomy Unknown status NCT00918528 Phase 1, Phase 2 Mitomycin C - local injection
10 Effectiveness and Safety of Endoscopically-Assisted Submucosal Administration of Autologous Adipose-Derived Regenerative Cells for the Treatment of Urethral Strictures Unknown status NCT01889888 Phase 1, Phase 2
11 Role of Uttarbasti in the Management of Mutra Marga Sankoch (Urethral Stricture) Completed NCT00535717 Phase 2
12 POIROT TRIAL: Post-Operative Imaging After Urethroplasty With Peri-catheter Retrograde Urethrography Or Trial of Voiding With Voiding Cysto-urethrography Recruiting NCT04307537 Phase 2
13 Clostridium Histolyticum Collagenase Injection Treatment for Urethral Disease: a Prospective, Single-center, Open-label Study Not yet recruiting NCT02948842 Phase 2 Clostridium Histolyticum Collagenase
14 A Phase 1 Pilot Safety and Feasibility Study of Autologous Engineered Urethral Not yet recruiting NCT03258658 Phase 1
15 Endoscopic Buccal Mucosal Graft Urethroplasty or Bladder Neck Reconstruction Not yet recruiting NCT03061344 Phase 1
16 A Comparison Between Tourniquet Application and Epinephrine Injection for Hemostasis During Hypospadias Surgery: the Effect on Bleeding and Post-operative Outcome Unknown status NCT02268019 epinephrine injection
17 Urethral Stricture Repair: A Prospective Randomized Analysis Between Jugal or Labial Graft in Buccal Mucosa Urethroplasty Completed NCT03973619
18 Prospective Long-term Single Center Cohort Study Assessing Functional Outcome of Urethral Reconstructive Surgery Completed NCT01982136
19 Factors Predicting Urethral Stricture Recurrence After Dorsal Onlay Augmented, Buccal Mucosal Graft Urethroplasty Completed NCT04357080
20 Early vs Late Urinary Catheter Removal After Renal Transplantation Randomised Clinical Trial Recruiting NCT04815954
21 VeSpAR: A Randomized Controlled Trial Comparing Vessel-Sparing Anastomotic Repair and Transecting Anastomotic Repair in Isolated Short Bulbar Urethral Strictures Recruiting NCT03572348
22 Feasibility and Therapeutic Potential of Free Fat Grafts in the Treatment of Urethral Strictures Recruiting NCT04161365
23 Scandinavian Urethroplasty Study. A Multicentre, Prospective, Randomized Study Comparing Bulbar Urethroplasty With Excision and Primary Anastomosis or With an Onlay Grafting Procedure Using Buccal Mucosa. Recruiting NCT02321670
24 Hormonal Status and Coagulative Disorders as Risk Factors for Urethral Stricture After Transurethral Resection of the Prostate/Bladder: A Prospective Study Recruiting NCT04795570
25 DoVe Trial: a Randomized Controlled Trial Comparing Dorsal Onlay Versus Ventral Onlay in Isolated Bulbar Urethral Strictures Recruiting NCT04551417
26 ROBUST III - Re-Establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease - A Randomized Control Trial Active, not recruiting NCT03499964
27 Re-establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease Active, not recruiting NCT03270384
28 ROBUST I Pilot Study, ROBUST I Study, Re-Establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease Active, not recruiting NCT03014726
29 An Open Prospective Clinical Study on Safety and Efficacy of Surgical Treatment of Patients With Anterior Urethral Stricture Using a Tissue-engineered Construct Based on Autologous Buccal Mucosa Cells and Matrix From Reconstituted Collagen and Reinforcing Polylactoglycolide Fibers Enrolling by invitation NCT03205670 Early Phase 1
30 9000 URETHRA STUDY: a Prospective, Observational Study About Urethroplasty for Urethral Stricture Disease Not yet recruiting NCT04071925
31 A Randomized Study of Dorsal Versus Ventral Buccal Mucosa Graft Onlay for Bulbar Urethroplasty Terminated NCT02551783
32 A Randomized Study of Dorsal Versus Ventral Buccal Mucosa Graft Onlay for Bulbar Urethroplasty Terminated NCT02634619
33 Re-Establishing Flow Via Drug Coated Balloon for the Treatment of Urethral Stricture Disease - Registry Study Withdrawn NCT03851952

Search NIH Clinical Center for Urethral Stricture

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Genetic Tests for Urethral Stricture

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Anatomical Context for Urethral Stricture

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MalaCards organs/tissues related to Urethral Stricture:

40
Prostate, Skin, Kidney, Spinal Cord, Heart, Breast, Bone Marrow
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Publications for Urethral Stricture

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Articles related to Urethral Stricture:

(show top 50) (show all 2973)
# Title Authors PMID Year
1
Factors affecting urethral stricture development after radical retropubic prostatectomy. 61 54
19165616 2009
2
Short-term results of rotoresection for benign prostatic hyperplasia: a prospective study of safety and efficacy. 61 54
14616452 2003
3
Urethral metastasis from primary embryonal carcinoma of testis - The first case report. 61
33532243 2021
4
Female Urethral Stricture Management: The Initial Experience of an Female Pelvic Medicine and Reconstructive Surgery-Trained Urologist. 61
33109930 2021
5
Re: Surgical Treatment for Recurrent Bulbar Urethral Stricture: A Randomised Open-label Superiority Trial of Open Urethroplasty Versus Endoscopic Urethrotomy (the OPEN Trial). 61
33293080 2021
6
Long-term outcomes for 2-stage urethroplasty: an analysis of risk factors for urethral stricture recurrence. 61
33811511 2021
7
Improvement in Storage Related Lower Urinary Tract Symptoms following Urethroplasty: A Prospective Cohort Study. 61
33216691 2021
8
Novel operative technique of advancement urethral meatoplasty utilizing buccal mucosa for Vulvar Paget's disease with urethral invasion: two case reports. 61
33773597 2021
9
Multi-factorial analysis of recurrence and complications of lingual mucosa graft urethroplasty for anterior urethral stricture: Experience from a Chinese referral center. 61
33785402 2021
10
Classification systems for anterior urethral stricture disease in men: a systematic review. 61
32451616 2021
11
Meatal-sparing dorsal onlay vaginal graft urethroplasty: widening the surgical horizons of female urethral stricture. 61
32926293 2021
12
Changes in patient reported outcome measures after treatment for female urethral stricture. 61
33719145 2021
13
Efficacy of re-do urethroplasty for post-traumatic urethral stricture: An analysis of the anatomical and functional outcomes. 61
33742496 2021
14
Mortality and Urological Complications After Open Groin Hernia Repair in Local, General, and Regional Anesthesia: A Nationwide Linked Register Study. 61
31578130 2021
15
Surgical Reintervention Rates after Invasive Treatment for Lower Urinary Tract Symptoms due to Benign Prostatic Syndrome: A Comparative Study of More than 43,000 Patients with Long-Term Followup. 61
33103943 2021
16
Safety and Efficacy of Outpatient Surgical Procedures for the Treatment of Benign Prostatic Enlargement in New York State and California (2005-2016). 61
33026907 2021
17
Complete Posterior Urethral Disruption Accompanied by Complex Pelvic Fractures: Clinical Outcomes of Fluoroscopic Primary Posterior Urethral Realignment. 61
33272814 2021
18
Technical modifications in dorsal onlay female urethroplasty: Time to make way for amendments. 61
33226324 2021
19
Exploring the intersection of functional recurrence, patient-reported sexual function, and treatment satisfaction after anterior buccal mucosal graft urethroplasty. 61
33709201 2021
20
Surgical Outcomes Following Gender Affirming Penile Reconstruction: Patient-Reported Outcomes From a Multi-Center, International Survey of 129 Transmasculine Patients. 61
33663938 2021
21
Frank haematuria secondary to ruptured pseudoaneurysm of the inferior vesical artery: a case report and review of the literature. 61
33712021 2021
22
Bittersweet: infective complications of drug-induced glycosuria in patients with diabetes mellitus on SGLT2-inhibitors: two case reports. 61
33743624 2021
23
Lichen sclerosis-induced long segment anterior urethral stricture: The early outcome of one-stage repair using dorsolateral onlay buccal mucosa graft. 61
33764232 2021
24
Significant Impact of the Anterior Transition Zone Portion Treatment on Urinary Function After Focal Therapy with High-Intensity Focused Ultrasound for Prostate Cancer. 61
33499743 2021
25
Risk factors for urethral stricture following external beam radiotherapy and HDR brachytherapy for prostate cancer. 61
33234408 2021
26
High-intensity Focused Ultrasound for the Treatment of Prostate Cancer: A National Cohort Study Focusing on the Development of Stricture and Fistulae. 61
31924529 2021
27
Spongiosum-combined glanuloplasty reduces glans complications after proximal hypospadias repair. 61
33723098 2021
28
A Systematic Review of Randomized Controlled Trials Comparing Buccal Mucosal Graft Harvest Site Non-Closure versus Closure in Patients Undergoing Urethral Reconstruction. 61
33663028 2021
29
Ventral Approach for the Non-transecting Bulbar Urethroplasty. 61
33577900 2021
30
Imaging spectrum of traumatic urinary bladder and urethral injuries. 61
32725483 2021
31
Dorsolateral inner preputial graft urethroplasty for anterior urethral strictures: long-term outcomes from a single tertiary care centre. 61
33582831 2021
32
Urethral Injury Treatment Challenge. Comparison of Surgical Treatments for Acquired or Iatrogenic Urethral Stenosis and Predictive Values for Failure of Each Surgical Method. 61
33650395 2021
33
Urinary System Iatrogenic Injuries: Problem Review. 61
33535218 2021
34
Urethral Complications While Using 26F vs 28F Resectoscope Sheaths in Holmium Laser Enucleation of the Prostate: A Retrospective Observational Study. 61
32873081 2021
35
Is Clitoral Release Another Term for Metoidioplasty? A Systematic Review and Meta-Analysis of Metoidioplasty Surgical Technique and Outcomes. 61
33429241 2021
36
A Rho kinase inhibitor (Fasudil) suppresses TGF-β mediated autophagy in urethra fibroblasts to attenuate traumatic urethral stricture (TUS) through re-activating Akt/mTOR pathway: An in vitro study. 61
33373654 2021
37
Transperineal-incision urethrectomy combined with laparoscopic prostatectomy for a male patient with squamous cell carcinoma involving distal plus proximal urethra and untypical symptoms-a case report. 61
33718098 2021
38
Editorial Comment to Ventral onlay buccal mucosa graft urethroplasty for female urethral stricture. 61
33550627 2021
39
A drug-coated balloon treatment for urethral stricture disease: Two-year results from the ROBUST I study. 61
32744999 2021
40
Identification of risk factors associated with numerous reoperations following primary hypospadias repair. 61
33246830 2021
41
Presentation, treatment and outcomes of pediatric anterior urethral strictures: 28 years' experience from a referral center. 61
33653664 2021
42
Patients presenting with lower urinary tract symptoms who most deserve to be investigated for primary bladder neck obstruction. 61
33603071 2021
43
Orchidopexy and Split-thickness Skin Graft for Scrotal Defects After Necrotizing Fasciitis. 61
33581235 2021
44
Photoselective Vaporization of the Prostate in the Management of Lower Urinary Tract Symptoms in Prostate Cancer Patients on Active Surveillance. 61
33539897 2021
45
Adult Acquired Buried Penis: A Hidden Problem in Obese Men. 61
33680609 2021
46
Synchronous genitourinary lichen sclerosus signals a distinct urinary microbiome profile in men with urethral stricture disease. 61
32274566 2021
47
The use of ileocecal pouch with appendix as an urethral substitute in patients who are willing to have a orthotopic bladder replacement - point of technique. 61
33622526 2021
48
Efficacy and Safety Evaluation of Transurethral Resection of the Prostate versus Plasmakinetic Enucleation of the Prostate in the Treatment of Massive Benign Prostatic Hyperplasia. 61
33524981 2021
49
Management of the Transitional Urology Patient: the Role of the Adult Reconstructive Urologist. 61
33534013 2021
50
Re: Beatriz Goulao, Sonya Carnell, Jing Shen, et al. Surgical Treatment for Recurrent Bulbar Urethral Stricture: A Randomised Open-label Superiority Trial of Open Urethroplasty Versus Endoscopic Urethrotomy (the OPEN Trial). Eur Urol 2020;78:572-80. 61
33143950 2021
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Variations for Urethral Stricture

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ClinVar genetic disease variations for Urethral Stricture:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 TBXAS1 GRCh37/hg19 7q34(chr7:139478979-139550968) copy number gain Uncertain significance 638674 GRCh37: 7:139478979-139550968
GRCh38:
2 GABRG3 GRCh37/hg19 15q12(chr15:27462869-27544157) copy number gain Uncertain significance 638675 GRCh37: 15:27462869-27544157
GRCh38:
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Expression for Urethral Stricture

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Search GEO for disease gene expression data for Urethral Stricture.
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Pathways for Urethral Stricture

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Pathways related to Urethral Stricture according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Adhesion 4
10.89 PLEC KLK3 CCN2
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GO Terms for Urethral Stricture

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Biological processes related to Urethral Stricture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.5 TGFB1 MIR21 CCN2
2 positive regulation of protein phosphorylation GO:0001934 9.43 TGFB1 MIR21 CCN2
3 positive regulation of collagen biosynthetic process GO:0032967 9.16 TGFB1 CCN2
4 negative regulation of reactive oxygen species biosynthetic process GO:1903427 8.96 PAGE4 MIR21
5 connective tissue development GO:0061448 8.62 TGFB1 CCN2
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Sources for Urethral Stricture

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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