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MCID: URT037
MIFTS: 33

Urethral Stricture

Categories: Nephrological diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Urethral Stricture

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MalaCards integrated aliases for Urethral Stricture:

Name: Urethral Stricture 12 55 44 15 73

Classifications:

MalaCards categories:
Anatomical: Nephrological diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:1829
ICD9CM 35 598.8
MeSH 44 D014525
ICD10 33 N35
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Summaries for Urethral Stricture

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MalaCards based summary : Urethral Stricture is related to urethral syndrome and urinary tract obstruction. An important gene associated with Urethral Stricture is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways is Adhesion. The drugs Bupivacaine and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include prostate, skin and kidney.

Wikipedia : 76 A urethral stricture is a narrowing of the urethra caused by injury, instrumentation, infection and... more...

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Related Diseases for Urethral Stricture

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Diseases related to Urethral Stricture via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 urethral syndrome 32.3 KLK3 MYZAP
2 urinary tract obstruction 29.9 CCN2 KLK3
3 infective urethral stricture 12.3
4 pigmentary disorder, reticulate, with systemic manifestations, x-linked 11.3
5 hypospadias 10.6
6 lichen sclerosus 10.5
7 prostate cancer 10.3
8 prostatic hyperplasia, benign 10.3
9 balanitis 10.3
10 balanitis xerotica obliterans 10.3
11 leukoplakia of penis 10.3
12 impotence 10.3
13 urethritis 10.2
14 posterior urethral valves 10.2
15 cystitis 10.1
16 squamous cell carcinoma 10.1
17 spinal cord injury 10.1
18 sensory peripheral neuropathy 10.1
19 neuropathy 10.1
20 eosinophilic cystitis 10.1
21 prostatic cyst 10.1 BCL2L10 KLK3
22 bladder neck obstruction 10.0 KLK3 SIRPA
23 urinary system disease 9.9 CCN2 KLK3
24 brain injury 9.9
25 end stage renal failure 9.9
26 gas gangrene 9.9
27 hemangioma 9.9
28 sexual disorder 9.9
29 renal hypoplasia 9.9
30 malignant hypertension 9.9
31 acute cystitis 9.9
32 schistosomiasis 9.9
33 prostatitis 9.9
34 lymphangioma 9.9
35 melanoma 9.9
36 orchitis 9.9
37 epidermolysis bullosa 9.9
38 prostatic adenoma 9.9
39 anuria 9.9
40 junctional epidermolysis bullosa 9.9
41 ischemia 9.9
42 urethra squamous cell carcinoma 9.9
43 primary syphilis 9.9
44 syphilis 9.9
45 amyloidosis 9.9
46 priapism 9.9
47 urethral diverticulum 9.9
48 epididymo-orchitis 9.9
49 fasciitis 9.9
50 necrotizing fasciitis 9.9

Comorbidity relations with Urethral Stricture via Phenotypic Disease Network (PDN): (show all 27)


Acute Cystitis Acute Kidney Failure
Balanoposthitis Bladder Cancer
Bladder Neck Obstruction Chronic Kidney Failure
Chronic Myocardial Ischemia Cystitis
Cystitis Cystica Deficiency Anemia
Epididymo-Orchitis Hydronephrosis
Ischemic Heart Disease Nephrolithiasis, X-Linked Recessive, with Renal Failure
Neurogenic Bladder Peyronie's Disease
Prostate Calculus Prostate Cancer
Prostatic Hypertrophy Prostatitis
Radiation Cystitis Trigonitis
Ureterolithiasis Urethral Calculus
Urethral Gland Abscess Urethritis
Urinary Tract Obstruction

Graphical network of the top 20 diseases related to Urethral Stricture:



Diseases related to Urethral Stricture
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Symptoms & Phenotypes for Urethral Stricture

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Drugs & Therapeutics for Urethral Stricture

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Drugs for Urethral Stricture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 3 2180-92-9, 38396-39-3 2474
2 Pharmaceutical Solutions Phase 3
3 Peripheral Nervous System Agents Phase 3,Phase 2,Not Applicable
4 Anesthetics Phase 3,Phase 1,Phase 2,Not Applicable
5 Anesthetics, Local Phase 3,Phase 2,Not Applicable
6 Central Nervous System Depressants Phase 3,Phase 2,Not Applicable
7
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
8 Antibiotics, Antitubercular Phase 1, Phase 2,Not Applicable
9 Anti-Bacterial Agents Phase 1, Phase 2,Not Applicable
10 Nucleic Acid Synthesis Inhibitors Phase 1, Phase 2
11 Mitomycins Phase 1, Phase 2
12 Alkylating Agents Phase 1, Phase 2
13 Anti-Arrhythmia Agents Phase 2
14 Diuretics, Potassium Sparing Phase 2
15 Sodium Channel Blockers Phase 2
16 Fibrin Tissue Adhesive Phase 1
17
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
18
Racepinephrine Approved Not Applicable 329-65-7 838
19
Paclitaxel Approved, Vet_approved Not Applicable 33069-62-4 36314
20
Glucosamine Approved, Investigational Not Applicable 3416-24-8 439213
21
Ropivacaine Approved Not Applicable 84057-95-4 175805 71273
22
leucovorin Approved Not Applicable 58-05-9 6006 143
23
Trimethoprim Approved, Vet_approved Not Applicable 738-70-5 5578
24
Sulfamethoxazole Approved Not Applicable 723-46-6 5329
25
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
26 Vasoconstrictor Agents Not Applicable
27 Adrenergic beta-Agonists Not Applicable
28 Anti-Asthmatic Agents Not Applicable
29 Mydriatics Not Applicable
30 Autonomic Agents Not Applicable
31 Adrenergic alpha-Agonists Not Applicable
32 Epinephryl borate Not Applicable
33 Adrenergic Agonists Not Applicable
34 Respiratory System Agents Not Applicable
35 Hemostatics Not Applicable
36 Neurotransmitter Agents Not Applicable
37 Adrenergic Agents Not Applicable
38 Coagulants Not Applicable
39 Bronchodilator Agents Not Applicable
40 Sympathomimetics Not Applicable
41 Albumin-Bound Paclitaxel Not Applicable
42 Glucuronyl glucosamine glycan sulfate Not Applicable
43 Hypoglycemic Agents Not Applicable
44 Lipid Regulating Agents Not Applicable
45 Anticoagulants Not Applicable
46 Hypolipidemic Agents Not Applicable
47 Antimetabolites Not Applicable
48 Fibrinolytic Agents Not Applicable
49 Antiparasitic Agents Not Applicable
50 Vitamin B9 Not Applicable

Interventional clinical trials:

(show all 30)
# Name Status NCT ID Phase Drugs
1 Efficiency of Cold vs. Laser Internal Urethrotomy Treatment of Urethral Strictures Unknown status NCT01196572 Phase 4
2 Diagnosis of Urethral Stricture With Sono-urethrography vs Conventional Urethrography (SONO-URETHRA) Unknown status NCT01790776 Phase 3
3 Memokath® 044TW Stent for Treatment of Urethral Stricture Completed NCT00270504 Phase 3
4 Liposomal Bupivacaine To Control Post-Operative Pain Following BMG Active, not recruiting NCT03720223 Phase 3 Liposomal Bupivacaine
5 Effect of Mitomycin C on Urethral Stricture Recurrence After Internal Urethrotomy Unknown status NCT00918528 Phase 1, Phase 2 Mitomycin C - local injection
6 Effectiveness and Safety of Autologous Adipose-Derived Regenerative Cells for the Treatment of Urethral Strictures Unknown status NCT01889888 Phase 1, Phase 2
7 Role of Uttarbasti in the Management of Mutra Marga Sankoch (Urethral Stricture) Completed NCT00535717 Phase 2
8 Clostridium Histolyticum Collagenase Injection for Urethral Disease Not yet recruiting NCT02948842 Phase 2 Clostridium Histolyticum Collagenase;Lidocaine
9 A Safety Evaluation of Renal Denervation Using Focused Therapeutic Ultrasound on Patients With Refractory Hypertension Completed NCT01638195 Phase 1
10 Safety and Feasibility Study of Autologous Engineered Urethral Constructs for the Treatment of Strictures Not yet recruiting NCT03258658 Phase 1
11 Liquid Buccal Mucosa Graft Urethroplasty Not yet recruiting NCT03061344 Phase 1
12 Hemostasis During Hypospadias Surgery Unknown status NCT02268019 Not Applicable epinephrine injection
13 The Improvement in Uroflow and Postvoid Residual Urine After Urethral Meatotomy in Children With Meatal Stenosis Completed NCT01214525
14 PVP Compared to TURP for the Treatment of Benign Hyperplasia of the Prostate Completed NCT00527371 Not Applicable
15 Re-establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease Recruiting NCT03270384 Not Applicable
16 ROBUST III- Re-Establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease Recruiting NCT03499964 Not Applicable
17 A Study of Dorsal Versus Ventral Buccal Mucosa Graft Onlay for Bulbar Urethroplasty Recruiting NCT02634619 Not Applicable
18 Functional Outcome of Urethral Reconstructive Surgery Recruiting NCT01982136
19 VeSpAR: Comparing Vessel-Sparing Anastomotic Repair and Transecting Anastomotic Repair in Isolated Short Bulbar Strictures. Recruiting NCT03572348 Not Applicable
20 Dorsal vs. Ventral Buccal Graft Dorsal vs. Ventral Buccal Graft Recruiting NCT02551783 Not Applicable
21 Scandinavian Urethroplasty Study Recruiting NCT02321670 Not Applicable
22 ProACT Post-Approval Study Recruiting NCT03767595 Not Applicable
23 Effect of Caudal and Penile Block on Hypospadias Repair Complications Recruiting NCT02851290 Not Applicable
24 A Prospective Evaluation of the Catheter Science M3 "Mini Catheter" for Patients With Prostatic Recruiting NCT03339076 Not Applicable
25 Transgender Post-reassignment Urogynecologic Measures and Perceptions Recruiting NCT03293771
26 ROBUST I Pilot Study Active, not recruiting NCT03014726 Not Applicable
27 Prophylactic Antibiotics or Placebo After Hypospadias Repair Active, not recruiting NCT02096159 Not Applicable trimethoprim-sulfamethoxazole
28 Tissue-engineered Construct Based on Buccal Mucosa Cells and Matrix From Collagen and Polylactoglycolide Fibers Enrolling by invitation NCT03205670 Early Phase 1
29 Comparison of Different Energy Sources During TUR-P Not yet recruiting NCT02533687 Not Applicable
30 Primary Urethral Realignment vs. Suprapubic Cystostomy for Initial Management of Pediatric Pelvic Fracture Urethral Injury Not yet recruiting NCT03468387 Not Applicable

Search NIH Clinical Center for Urethral Stricture

Cochrane evidence based reviews: urethral stricture

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Genetic Tests for Urethral Stricture

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Anatomical Context for Urethral Stricture

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MalaCards organs/tissues related to Urethral Stricture:

41
Prostate, Skin, Kidney, Colon, Small Intestine, Spinal Cord, Brain
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Publications for Urethral Stricture

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Articles related to Urethral Stricture:

(show top 50) (show all 757)
# Title Authors Year
1
Refractory Urethral Stricture Management: Indications for Alternative Grafts and Flaps. ( 29479650 )
2018
2
A case of spontaneous urinary bladder rupture secondary to urinary retention due to an urethral stricture. ( 29541588 )
2018
3
Management of long segment anterior urethral stricture (a8Y 8cm) using buccal mucosal (BM) graft and penile skin (PS) flap: outcome and predictors of failure. ( 29211404 )
2018
4
Endoscopic Management of Urethral Stricture: Review and Practice Algorithm for Management of Male Urethral Stricture Disease. ( 29479640 )
2018
5
Re: Repair of pan-urethral stricture: Proximal ventral and distal dorsal onlay technique of buccal mucosal graft urethroplasty. By Subbarao Chodisetti, Yogesh Boddepalli, Malakondareddy Kota. ( 29892485 )
2018
6
A novel heterozygous GLI2 mutation in a patient with congenital urethral stricture and renal hypoplasia/dysplasia leading to end-stage renal failure. ( 29318530 )
2018
7
Re: Urethral Stricture Outcomes after Artificial Urinary Sphincter Cuff Erosion: Results from a Multicenter Retrospective Analysis. ( 29357550 )
2018
8
Re: Low Testosterone Levels Result in Decreased Periurethral Vascularity via an Androgen Receptor-Mediated Process: Pilot Study in Urethral Stricture Tissue. ( 29357549 )
2018
9
Hypoandrogenism is Prevalent in Males with Urethral Stricture Disease and is Associated with Longer Strictures. ( 29378279 )
2018
10
Long term follow up of proximal hypospadias repair-urethral stricture should be excluded in adults who present with epididymo-orchitis. ( 29511587 )
2018
11
Long-term Effect of Colchicine Treatment in Preventing Urethral Stricture Recurrence After Internal Urethrotomy. ( 29681046 )
2018
12
microRNA expression profiles of scar and normal tissue from patients with posterior urethral stricture caused by pelvic fracture urethral distraction defects. ( 29436608 )
2018
13
An Experimental Model of Anterior Urethral Stricture in Rabbits With Local Injections of Bleomycin. ( 29545036 )
2018
14
Ejaculatory Disorders in Men With Urethral Stricture and Impact of Urethroplasty on the Ejaculatory Function: A Systematic Review. ( 29960631 )
2018
15
Retroperitoneal necrotizing fasciitis with gas gangrene caused by urethral stricture. ( 29984183 )
2018
16
Re: Cultural background, non-therapeutic circumcision and the risk of meatal stenosis and other urethral stricture disease: Two nationwide register-based cohort studies in Denmark 1977-2013. ( 28869139 )
2018
17
Anti-fibrotic function of Cu-bearing stainless steel for reducing recurrence of urethral stricture after stent implantation. ( 29068537 )
2018
18
A Simplified Adult Acquired Buried Penis Repair Classification System With an Analysis of Perioperative Complications and Urethral Stricture Disease. ( 29898381 )
2018
19
Validated uroflowmetry-based predictive model for the primary diagnosis of urethral stricture disease in men. ( 30021245 )
2018
20
Editorial Comment to Validated uroflowmetry-based predictive model for the primary diagnosis of urethral stricture disease in men. ( 30066428 )
2018
21
Penile fasciocutaneous flap urethroplasty for the reconstruction of pediatric long anterior urethral stricture. ( 30131215 )
2018
22
Population Analysis of Male Urethral Stricture Management and Urethroplasty Success in the United States. ( 30170091 )
2018
23
miR-21 modification enhances the performance of adipose tissue-derived mesenchymal stem cells for counteracting urethral stricture formation. ( 30179296 )
2018
24
International volunteerism and urethral stricture disease: a review. ( 30211056 )
2018
25
U-score system for predicting time to recurrence after urethral reconstruction in patients with anterior urethral stricture. ( 30221414 )
2018
26
Prevalence and surgical management of concurrent adult acquired buried penis and urethral stricture disease. ( 30298286 )
2018
27
Familial Urethral Stricture, Five Adult patients overview. ( 30318567 )
2018
28
Effect of angiotensin II receptor blocker on TGF-β1, MMP-1, and collagen type I and type III concentration in New Zealand rabbit urethral stricture model. ( 30324094 )
2018
29
Assessment of quality of life in patients of urethral stricture on clean intermittent catheterization following direct vision internal urethrotomy. ( 30386093 )
2018
30
Risk factors for urethral stricture and/or bladder neck contracture after monopolar transurethral resection of the prostate for benign prostatic hyperplasia. ( 30426880 )
2018
31
Buccal epithelium Expanded and Encapsulated in Scaffold-Hybrid Approach to Urethral Stricture (BEES-HAUS) procedure: A novel cell therapy-based pilot study. ( 30468021 )
2018
32
Characteristics of the urethroplasty and our approach-Experience in patients with urethral stricture. ( 30468425 )
2018
33
Editorial Comment from Dr Horiguchi to Buccal epithelium Expanded and Encapsulated in Scaffold-Hybrid Approach to Urethral Stricture (BEES-HAUS) procedure: A novel cell therapy-based pilot study. ( 30485905 )
2018
34
Imbalance in extracellular matrix degradation in urethral stricture. ( 30538969 )
2018
35
Editorial Comment from Dr Takao to Buccal epithelium Expanded and Encapsulated in Scaffold-Hybrid Approach to Urethral Stricture (BEES-HAUS) procedure: A novel cell therapy-based pilot study. ( 30556177 )
2018
36
Re: The International Prostate Symptom Score (IPSS) is an Inadequate Tool toA Screen for Urethral Stricture Recurrence after Anterior Urethroplasty. ( 29539918 )
2017
37
Management of bladder neck stenosis and urethral stricture and stenosis following treatment for prostate cancer. ( 28791228 )
2017
38
Incidence and predictors of complications due to urethral stricture in patients awaiting urethroplasty. ( 28899769 )
2017
39
Definition of Successful Treatment and Optimal Follow-up after Urethral Reconstruction for Urethral Stricture Disease. ( 27908363 )
2017
40
Substitution urethroplasty for anterior urethral stricture repair: comparison between lingual mucosa graft and pedicled skin flap. ( 28738760 )
2017
41
Double inlay plus ventral onlay buccal mucosa graft for simultaneous penile and bulbar urethral stricture. ( 29135409 )
2017
42
The predictive value of platelet to lymphocyte and neutrophil to lymphocyte ratio in determining urethral stricture after transurethral resection of prostate. ( 28861306 )
2017
43
Three-Dimensional Computerized Model Based on the Sonourethrogram: A Novel Technique for Evaluating the Anterior Urethral Stricture. ( 28866465 )
2017
44
Anastomotic Urethroplasty for an Obstructing Calculus Within a Bulbar Urethral Diverticulum and Urethral Stricture. ( 27981035 )
2017
45
Understanding patients' preferences for surgical management of urethral stricture disease. ( 28664240 )
2017
46
Management of Urethral Stricture and Bladder Neck Contracture Following Primary and Salvage Treatment of Prostate Cancer. ( 28776126 )
2017
47
Delayed primary end-to-end anastomosis for traumatic long segment urethral stricture and its short-term outcomes. ( 29487268 )
2017
48
Fulfilling Patient Expectations of Urethral Stricture Surgery. ( 28822234 )
2017
49
AT<sub>1</sub>expression in human urethral stricture tissue. ( 28979891 )
2017
50
Editorial Comment to Substitution urethroplasty using oral mucosa graft for male anterior urethral stricture disease: Current topics and reviews. ( 28626935 )
2017
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Variations for Urethral Stricture

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Expression for Urethral Stricture

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Search GEO for disease gene expression data for Urethral Stricture.
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Pathways for Urethral Stricture

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Pathways related to Urethral Stricture according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Adhesion 4
10.89 CCN2 KLK3 SIRPA
Sources

GO Terms for Urethral Stricture

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Sources for Urethral Stricture

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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