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MCID: URT037
MIFTS: 34

Urethral Stricture

Categories: Nephrological diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Urethral Stricture

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MalaCards integrated aliases for Urethral Stricture:

Name: Urethral Stricture 12 56 45 15 74

Classifications:

MalaCards categories:
Anatomical: Nephrological diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:1829
ICD9CM 36 598.8
MeSH 45 D014525
ICD10 34 N35
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Summaries for Urethral Stricture

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MalaCards based summary : Urethral Stricture is related to urethral syndrome and urinary tract obstruction. An important gene associated with Urethral Stricture is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways is Adhesion. The drugs Diclofenac and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include skin, prostate and kidney.

Wikipedia : 77 A urethral stricture is a narrowing of the urethra caused by injury, instrumentation, infection, and... more...

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Related Diseases for Urethral Stricture

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Diseases related to Urethral Stricture via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 urethral syndrome 32.5 KLK3 MYZAP
2 urinary tract obstruction 29.9 CCN2 KLK3
3 infective urethral stricture 12.3
4 pigmentary disorder, reticulate, with systemic manifestations, x-linked 11.3
5 hypospadias 10.6
6 lichen sclerosus 10.5
7 impotence 10.3
8 prostate cancer 10.3
9 prostatic hyperplasia, benign 10.3
10 prostate cancer, hereditary, 8 10.3
11 prostate cancer, hereditary, 6 10.3
12 balanitis 10.3
13 balanitis xerotica obliterans 10.3
14 leukoplakia of penis 10.3
15 urethritis 10.2
16 posterior urethral valves 10.2
17 cystitis 10.2
18 squamous cell carcinoma 10.2
19 spinal cord injury 10.1
20 sensory peripheral neuropathy 10.1
21 neuropathy 10.1
22 eosinophilic cystitis 10.1
23 prostatic cyst 10.0 BCL2L10 KLK3
24 bladder neck obstruction 10.0 KLK3 SIRPA
25 horns in sheep 9.9
26 brain injury 9.9
27 end stage renal failure 9.9
28 gas gangrene 9.9
29 hemangioma 9.9
30 sexual disorder 9.9
31 renal hypoplasia 9.9
32 acute cystitis 9.9
33 schistosomiasis 9.9
34 prostatitis 9.9
35 lymphangioma 9.9
36 melanoma 9.9
37 orchitis 9.9
38 epidermolysis bullosa 9.9
39 prostatic adenoma 9.9
40 anuria 9.9
41 junctional epidermolysis bullosa 9.9
42 ischemia 9.9
43 urethra squamous cell carcinoma 9.9
44 primary syphilis 9.9
45 syphilis 9.9
46 amyloidosis 9.9
47 priapism 9.9
48 urethral diverticulum 9.9
49 epididymo-orchitis 9.9
50 fasciitis 9.9

Comorbidity relations with Urethral Stricture via Phenotypic Disease Network (PDN): (show all 27)


Acute Cystitis Acute Kidney Failure
Balanoposthitis Bladder Cancer
Bladder Neck Obstruction Chronic Kidney Failure
Chronic Myocardial Ischemia Cystitis
Cystitis Cystica Deficiency Anemia
Epididymo-Orchitis Hydronephrosis
Ischemic Heart Disease Nephrolithiasis, X-Linked Recessive, with Renal Failure
Neurogenic Bladder Peyronie's Disease
Prostate Calculus Prostate Cancer
Prostatic Hypertrophy Prostatitis
Radiation Cystitis Trigonitis
Ureterolithiasis Urethral Calculus
Urethral Gland Abscess Urethritis
Urinary Tract Obstruction

Graphical network of the top 20 diseases related to Urethral Stricture:



Diseases related to Urethral Stricture
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Symptoms & Phenotypes for Urethral Stricture

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Drugs & Therapeutics for Urethral Stricture

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Drugs for Urethral Stricture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 87)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
2
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
3
Bupivacaine Approved, Investigational Phase 4,Phase 3 2180-92-9, 38396-39-3 2474
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
5
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
6
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
7
Ibuprofen Approved Phase 4 15687-27-1 3672
8
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
9
Acetaminophen Approved Phase 4 103-90-2 1983
10
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
11 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
12 Neurotransmitter Agents Phase 4,Not Applicable
13 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
14 Autonomic Agents Phase 4,Not Applicable
15 Anti-Inflammatory Agents Phase 4
16 Cyclooxygenase Inhibitors Phase 4
17 Anti-Inflammatory Agents, Non-Steroidal Phase 4
18 Analgesics Phase 4
19 Antirheumatic Agents Phase 4
20 Analgesics, Non-Narcotic Phase 4
21 Anesthetics, Local Phase 4,Phase 3,Phase 2,Not Applicable
22 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
23 Excitatory Amino Acids Phase 4
24 glucocorticoids Phase 4
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
26 Tranquilizing Agents Phase 4
27 Gastrointestinal Agents Phase 4
28 Anticonvulsants Phase 4
29 Antiemetics Phase 4
30 Anti-Anxiety Agents Phase 4
31 Antineoplastic Agents, Hormonal Phase 4
32 Hormone Antagonists Phase 4
33 Antipyretics Phase 4
34 Cyclooxygenase 2 Inhibitors Phase 4
35 Narcotics Phase 4
36
protease inhibitors Phase 4
37 Hormones Phase 4
38 Psychotropic Drugs Phase 4
39 BB 1101 Phase 4
40 Analgesics, Opioid Phase 4
41 Excitatory Amino Acid Antagonists Phase 4
42 HIV Protease Inhibitors Phase 4
43 Antimanic Agents Phase 4
44 Pharmaceutical Solutions Phase 3
45 Mitomycins Phase 1, Phase 2
46 Anti-Bacterial Agents Phase 1, Phase 2,Not Applicable
47 Nucleic Acid Synthesis Inhibitors Phase 1, Phase 2
48 Alkylating Agents Phase 1, Phase 2
49 Antibiotics, Antitubercular Phase 1, Phase 2,Not Applicable
50 Sodium Channel Blockers Phase 2

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 Efficiency of Cold vs. Laser Internal Urethrotomy Treatment of Urethral Strictures Unknown status NCT01196572 Phase 4
2 The Effect of Preemptive Analgesia On The Comfort Of Patient and Doctor, in Cystoscopy Recruiting NCT03831321 Phase 4 Diclofenac Sodium;Lubricant Gel
3 Efficacy of Opioid-limiting Pain Management Protocol in Men Undergoing Urethroplasty Not yet recruiting NCT03859024 Phase 4 Oxycodone;Acetaminophen;Gabapentin;celebrex;Bupivacaine;Ibuprofen 800 mg;Dexamethasone
4 Diagnosis of Urethral Stricture With Sono-urethrography vs Conventional Urethrography (SONO-URETHRA) Unknown status NCT01790776 Phase 3
5 Memokath® 044TW Stent for Treatment of Urethral Stricture Completed NCT00270504 Phase 3
6 Liposomal Bupivacaine To Control Post-Operative Pain Following BMG Active, not recruiting NCT03720223 Phase 3 Liposomal Bupivacaine
7 Effect of Mitomycin C on Urethral Stricture Recurrence After Internal Urethrotomy Unknown status NCT00918528 Phase 1, Phase 2 Mitomycin C - local injection
8 Effectiveness and Safety of Autologous Adipose-Derived Regenerative Cells for the Treatment of Urethral Strictures Unknown status NCT01889888 Phase 1, Phase 2
9 Role of Uttarbasti in the Management of Mutra Marga Sankoch (Urethral Stricture) Completed NCT00535717 Phase 2
10 Clostridium Histolyticum Collagenase Injection for Urethral Disease Not yet recruiting NCT02948842 Phase 2 Clostridium Histolyticum Collagenase;Lidocaine
11 A Safety Evaluation of Renal Denervation Using Focused Therapeutic Ultrasound on Patients With Refractory Hypertension Completed NCT01638195 Phase 1
12 Liquid Buccal Mucosa Graft Urethroplasty Not yet recruiting NCT03061344 Phase 1
13 Safety and Feasibility Study of Autologous Engineered Urethral Constructs for the Treatment of Strictures Suspended NCT03258658 Phase 1
14 Hemostasis During Hypospadias Surgery Unknown status NCT02268019 Not Applicable epinephrine injection
15 Comparison of Different Energy Sources During TUR-P Unknown status NCT02533687 Not Applicable
16 PVP Compared to TURP for the Treatment of Benign Hyperplasia of the Prostate Completed NCT00527371 Not Applicable
17 Re-establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease Recruiting NCT03270384 Not Applicable
18 ROBUST III- Re-Establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease Recruiting NCT03499964 Not Applicable
19 A Study of Dorsal Versus Ventral Buccal Mucosa Graft Onlay for Bulbar Urethroplasty Recruiting NCT02634619 Not Applicable
20 Functional Outcome of Urethral Reconstructive Surgery Recruiting NCT01982136
21 VeSpAR: Comparing Vessel-Sparing Anastomotic Repair and Transecting Anastomotic Repair in Isolated Short Bulbar Strictures. Recruiting NCT03572348 Not Applicable
22 Dorsal vs. Ventral Buccal Graft Dorsal vs. Ventral Buccal Graft Recruiting NCT02551783 Not Applicable
23 Scandinavian Urethroplasty Study Recruiting NCT02321670 Not Applicable
24 ProACT Post-Approval Study Recruiting NCT03767595 Not Applicable
25 Effect of Caudal and Penile Block on Hypospadias Repair Complications Recruiting NCT02851290 Not Applicable
26 A Prospective Evaluation of the Catheter Science M3 "Mini Catheter" for Patients With Prostatic Recruiting NCT03339076 Not Applicable
27 Transgender Post-reassignment Urogynecologic Measures and Perceptions Recruiting NCT03293771
28 ROBUST I Pilot Study Active, not recruiting NCT03014726 Not Applicable
29 Prophylactic Antibiotics or Placebo After Hypospadias Repair Active, not recruiting NCT02096159 Not Applicable trimethoprim-sulfamethoxazole
30 Tissue-engineered Construct Based on Buccal Mucosa Cells and Matrix From Collagen and Polylactoglycolide Fibers Enrolling by invitation NCT03205670 Early Phase 1
31 Re-Establishing Flow Via Drug Coated Balloon for the Treatment of Urethral Stricture Disease - Registry Study Not yet recruiting NCT03851952 Not Applicable
32 Primary Urethral Realignment vs. Suprapubic Cystostomy for Initial Management of Pediatric Pelvic Fracture Urethral Injury Not yet recruiting NCT03468387 Not Applicable

Search NIH Clinical Center for Urethral Stricture

Cochrane evidence based reviews: urethral stricture

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Genetic Tests for Urethral Stricture

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Anatomical Context for Urethral Stricture

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MalaCards organs/tissues related to Urethral Stricture:

42
Skin, Prostate, Kidney, Colon, Small Intestine, Spinal Cord, Bone
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Publications for Urethral Stricture

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Articles related to Urethral Stricture:

(show top 50) (show all 774)
# Title Authors Year
1
Insights into the pathophysiology of urethral stricture disease due to lichen sclerosus: comparison of pathologic markers in lichen sclerosus induced strictures versus non-lichen sclerosus induced strictures. ( 30835614 )
2019
2
Buccal epithelium Expanded and Encapsulated in Scaffold-Hybrid Approach to Urethral Stricture (BEES-HAUS) procedure: A novel cell therapy-based pilot study. ( 30468021 )
2019
3
Editorial Comment from Dr Horiguchi to Buccal epithelium Expanded and Encapsulated in Scaffold-Hybrid Approach to Urethral Stricture (BEES-HAUS) procedure: A novel cell therapy-based pilot study. ( 30485905 )
2019
4
Editorial Comment from Dr Takao to Buccal epithelium Expanded and Encapsulated in Scaffold-Hybrid Approach to Urethral Stricture (BEES-HAUS) procedure: A novel cell therapy-based pilot study. ( 30556177 )
2019
5
Gel-Infused Translabial Ultrasound in the Evaluation of Female Urethral Stricture. ( 30664026 )
2019
6
Urinary and sexual function after perineal urethrostomy for urethral stricture disease: An analysis from Trauma and Urologic Reconstructive Network of Surgeons (TURNS). ( 30676476 )
2019
7
Urethral stricture after bipolar transurethral resection of prostate - truth vs hype: A randomized controlled trial. ( 30692723 )
2019
8
Clinical significance of cystoscopic urethral stricture recurrence after anterior urethroplasty: a multi-institution analysis from Trauma and Urologic Reconstructive Network of Surgeons (TURNS). ( 30712091 )
2019
9
Socioeconomic and patient-related factors for the management of male urethral stricture disease. ( 30810835 )
2019
10
Effect of preoperative urethral dilatation on preventing urethral stricture after holmium laser enucleation of the prostate: A randomized controlled study. ( 30817290 )
2019
11
Case of wide calibre false urethral passage in a patient of urethral stricture. ( 30826787 )
2019
12
Is minimal invasive technique harmful in treatment of urethral stricture? ( 30837431 )
2019
13
Multiple Urethral Hemangiomas Associated with Urethral Stricture: An Uncommon Aetiology for Urethral Bleeding. ( 30863652 )
2019
14
Reconstruction of the urethra with an anterior vaginal mucosal flap in female urethral stricture. ( 30877352 )
2019
15
Trends in Urethral Stricture Disease Etiology and Urethroplasty Technique from a Multi-Institutional Surgical Outcomes Research Group. ( 30880075 )
2019
16
Comparison between cold knife and laser urethrotomy for urethral stricture: a systematic review and meta-analysis of comparative trials. ( 30895360 )
2019
17
Female Urethroplasty: A Practical Guide Emphasizing Diagnosis and Surgical Treatment of Female Urethral Stricture Disease. ( 30906779 )
2019
18
Refractory Urethral Stricture Management: Indications for Alternative Grafts and Flaps. ( 29479650 )
2018
19
A case of spontaneous urinary bladder rupture secondary to urinary retention due to an urethral stricture. ( 29541588 )
2018
20
Management of long segment anterior urethral stricture (a8Y 8cm) using buccal mucosal (BM) graft and penile skin (PS) flap: outcome and predictors of failure. ( 29211404 )
2018
21
Endoscopic Management of Urethral Stricture: Review and Practice Algorithm for Management of Male Urethral Stricture Disease. ( 29479640 )
2018
22
Re: Repair of pan-urethral stricture: Proximal ventral and distal dorsal onlay technique of buccal mucosal graft urethroplasty. By Subbarao Chodisetti, Yogesh Boddepalli, Malakondareddy Kota. ( 29892485 )
2018
23
A novel heterozygous GLI2 mutation in a patient with congenital urethral stricture and renal hypoplasia/dysplasia leading to end-stage renal failure. ( 29318530 )
2018
24
Re: Urethral Stricture Outcomes after Artificial Urinary Sphincter Cuff Erosion: Results from a Multicenter Retrospective Analysis. ( 29357550 )
2018
25
Re: Low Testosterone Levels Result in Decreased Periurethral Vascularity via an Androgen Receptor-Mediated Process: Pilot Study in Urethral Stricture Tissue. ( 29357549 )
2018
26
Hypoandrogenism is Prevalent in Males with Urethral Stricture Disease and is Associated with Longer Strictures. ( 29378279 )
2018
27
Long term follow up of proximal hypospadias repair-urethral stricture should be excluded in adults who present with epididymo-orchitis. ( 29511587 )
2018
28
Long-term Effect of Colchicine Treatment in Preventing Urethral Stricture Recurrence After Internal Urethrotomy. ( 29681046 )
2018
29
microRNA expression profiles of scar and normal tissue from patients with posterior urethral stricture caused by pelvic fracture urethral distraction defects. ( 29436608 )
2018
30
An Experimental Model of Anterior Urethral Stricture in Rabbits With Local Injections of Bleomycin. ( 29545036 )
2018
31
Ejaculatory Disorders in Men With Urethral Stricture and Impact of Urethroplasty on the Ejaculatory Function: A Systematic Review. ( 29960631 )
2018
32
A Simplified Adult Acquired Buried Penis Repair Classification System with an Analysis of Perioperative Complications and Urethral Stricture Disease<sup>,,a9^a9^a9^</sup>. ( 29898381 )
2018
33
Retroperitoneal necrotizing fasciitis with gas gangrene caused by urethral stricture. ( 29984183 )
2018
34
Validated uroflowmetry-based predictive model for the primary diagnosis of urethral stricture disease in men. ( 30021245 )
2018
35
Editorial Comment to Validated uroflowmetry-based predictive model for the primary diagnosis of urethral stricture disease in men. ( 30066428 )
2018
36
Penile fasciocutaneous flap urethroplasty for the reconstruction of pediatric long anterior urethral stricture. ( 30131215 )
2018
37
Population Analysis of Male Urethral Stricture Management and Urethroplasty Success in the United States. ( 30170091 )
2018
38
miR-21 modification enhances the performance of adipose tissue-derived mesenchymal stem cells for counteracting urethral stricture formation. ( 30179296 )
2018
39
International volunteerism and urethral stricture disease: a review. ( 30211056 )
2018
40
U-score system for predicting time to recurrence after urethral reconstruction in patients with anterior urethral stricture. ( 30221414 )
2018
41
Prevalence and surgical management of concurrent adult acquired buried penis and urethral stricture disease. ( 30298286 )
2018
42
Familial Urethral Stricture, Five Adult patients overview. ( 30318567 )
2018
43
Effect of angiotensin II receptor blocker on TGF-β1, MMP-1, and collagen type I and type III concentration in New Zealand rabbit urethral stricture model. ( 30324094 )
2018
44
Assessment of quality of life in patients of urethral stricture on clean intermittent catheterization following direct vision internal urethrotomy. ( 30386093 )
2018
45
Risk factors for urethral stricture and/or bladder neck contracture after monopolar transurethral resection of the prostate for benign prostatic hyperplasia. ( 30426880 )
2018
46
Characteristics of the urethroplasty and our approach-Experience in patients with urethral stricture. ( 30468425 )
2018
47
Imbalance in extracellular matrix degradation in urethral stricture. ( 30538969 )
2018
48
Evaluation of Generic Versus Condition-Specific Quality of Life Indicators for Successful Urethral Stricture Surgery. ( 30580004 )
2018
49
The Benefits of Using a Small Caliber Ureteroscope in Evaluation and Management of Urethral Stricture. ( 30584423 )
2018
50
Female Urethral Stricture: NYU Case of the Month, September 2018. ( 30787676 )
2018
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Variations for Urethral Stricture

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Expression for Urethral Stricture

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Search GEO for disease gene expression data for Urethral Stricture.
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Pathways for Urethral Stricture

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Pathways related to Urethral Stricture according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Adhesion 4
10.89 CCN2 KLK3 SIRPA
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GO Terms for Urethral Stricture

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Sources for Urethral Stricture

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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