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MCID: URT037
MIFTS: 35

Urethral Stricture

Categories: Nephrological diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Urethral Stricture

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MalaCards integrated aliases for Urethral Stricture:

Name: Urethral Stricture 12 55 15 73

Classifications:

MalaCards categories:
Anatomical: Nephrological diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:1829
ICD9CM 35 598.8
ICD10 33 N35
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Summaries for Urethral Stricture

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MalaCards based summary : Urethral Stricture is related to urethral syndrome and urinary tract obstruction. An important gene associated with Urethral Stricture is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways is Adhesion. The drugs Pharmaceutical Solutions and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include prostate, skin and kidney.

Wikipedia : 76 A urethral stricture is a narrowing of the urethra caused by injury, instrumentation, infection and... more...

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Related Diseases for Urethral Stricture

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Diseases related to Urethral Stricture via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 urethral syndrome 32.2 BCL2L10 KLK3
2 urinary tract obstruction 29.6 CTGF KLK3
3 infective urethral stricture 12.1
4 urethritis 11.2
5 pigmentary disorder, reticulate, with systemic manifestations, x-linked 11.1
6 prostatitis 10.6
7 mucositis 10.5
8 hypospadias 10.4
9 lichen sclerosus 10.3
10 prostate cancer 10.2
11 balanitis 10.2
12 balanitis xerotica obliterans 10.2
13 vaginitis 10.2
14 leukoplakia of penis 10.2
15 prostatic hyperplasia, benign 10.1
16 prostatic cyst 10.1 BCL2L10 KLK3
17 impotence 10.1
18 posterior urethral valves 10.1
19 cystitis 10.0
20 squamous cell carcinoma 10.0
21 bladder neck obstruction 10.0 KLK3 SIRPA
22 spinal cord injury 9.9
23 sensory peripheral neuropathy 9.9
24 neuropathy 9.9
25 eosinophilic cystitis 9.9
26 ureterocele 9.8
27 transsexuality 9.8
28 brain injury 9.8
29 end stage renal failure 9.8
30 hemangioma 9.8
31 renal hypoplasia 9.8
32 malignant hypertension 9.8
33 transsexualism 9.8
34 schistosomiasis 9.8
35 lymphangioma 9.8
36 melanoma 9.8
37 orchitis 9.8
38 epidermolysis bullosa 9.8
39 junctional epidermolysis bullosa 9.8
40 ischemia 9.8
41 urethra squamous cell carcinoma 9.8
42 primary syphilis 9.8
43 syphilis 9.8
44 neuronitis 9.8
45 priapism 9.8
46 urethral diverticulum 9.8
47 epididymo-orchitis 9.8
48 type i 9.8
49 urachal diverticulum 9.8
50 urinary system disease 9.7 CTGF KLK3

Comorbidity relations with Urethral Stricture via Phenotypic Disease Network (PDN): (show all 27)


Acute Cystitis Acute Kidney Failure
Balanoposthitis Bladder Cancer
Bladder Neck Obstruction Chronic Kidney Failure
Chronic Myocardial Ischemia Cystitis
Cystitis Cystica Deficiency Anemia
Epididymo-Orchitis Hydronephrosis
Ischemic Heart Disease Nephrolithiasis, X-Linked Recessive, with Renal Failure
Neurogenic Bladder Peyronie's Disease
Prostate Calculus Prostate Cancer
Prostatic Hypertrophy Prostatitis
Radiation Cystitis Trigonitis
Ureterolithiasis Urethral Calculus
Urethral Gland Abscess Urethritis
Urinary Tract Obstruction

Graphical network of the top 20 diseases related to Urethral Stricture:



Diseases related to Urethral Stricture
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Symptoms & Phenotypes for Urethral Stricture

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Drugs & Therapeutics for Urethral Stricture

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Drugs for Urethral Stricture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 3
2
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
3 Alkylating Agents Phase 1, Phase 2
4 Anti-Bacterial Agents Phase 1, Phase 2,Not Applicable
5 Antibiotics, Antitubercular Phase 1, Phase 2,Not Applicable
6 Mitomycins Phase 1, Phase 2
7 Nucleic Acid Synthesis Inhibitors Phase 1, Phase 2
8 Anesthetics Phase 1, Phase 2,Phase 2,Not Applicable
9 Peripheral Nervous System Agents Phase 2,Not Applicable
10 Anesthetics, Local Phase 2,Not Applicable
11 Central Nervous System Depressants Phase 2,Not Applicable
12 Anti-Arrhythmia Agents Phase 2
13 Diuretics, Potassium Sparing Phase 2
14 Sodium Channel Blockers Phase 2
15 Fibrin Tissue Adhesive Phase 1
16
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
17
Racepinephrine Approved Not Applicable 329-65-7 838
18
Paclitaxel Approved, Vet_approved Not Applicable 33069-62-4 36314
19
Menthol Approved Early Phase 1 2216-51-5 16666
20
Ropivacaine Approved Not Applicable 84057-95-4 71273 175805
21
Sulfamethoxazole Approved Not Applicable 723-46-6 5329
22
Trimethoprim Approved, Vet_approved Not Applicable 738-70-5 5578
23
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
24
leucovorin Approved, Nutraceutical Not Applicable 58-05-9 143 6006
25 Adrenergic Agents Not Applicable
26 Adrenergic Agonists Not Applicable
27 Adrenergic alpha-Agonists Not Applicable
28 Adrenergic beta-Agonists Not Applicable
29 Anti-Asthmatic Agents Not Applicable
30 Autonomic Agents Not Applicable
31 Bronchodilator Agents Not Applicable
32 Coagulants Not Applicable
33 Epinephryl borate Not Applicable
34 Hemostatics Not Applicable
35 Mydriatics Not Applicable
36 Neurotransmitter Agents Not Applicable
37 Respiratory System Agents Not Applicable
38 Vasoconstrictor Agents Not Applicable
39 Albumin-Bound Paclitaxel Not Applicable
40 Anti-Infective Agents Not Applicable
41 Antimalarials Not Applicable
42 Antiparasitic Agents Not Applicable
43 Antiprotozoal Agents Not Applicable
44 Cytochrome P-450 Enzyme Inhibitors Not Applicable
45 Folic Acid Antagonists Not Applicable
46 Renal Agents Not Applicable
47 Trimethoprim, Sulfamethoxazole Drug Combination Not Applicable
48 Vitamin B Complex Not Applicable
49 Folate Nutraceutical Not Applicable
50 Vitamin B9 Nutraceutical Not Applicable

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 Efficiency of Cold vs. Laser Internal Urethrotomy Treatment of Urethral Strictures Unknown status NCT01196572 Phase 4
2 Diagnosis of Urethral Stricture With Sono-urethrography vs Conventional Urethrography (SONO-URETHRA) Unknown status NCT01790776 Phase 3
3 Memokath® 044TW Stent for Treatment of Urethral Stricture Completed NCT00270504 Phase 3
4 Effect of Mitomycin C on Urethral Stricture Recurrence After Internal Urethrotomy Unknown status NCT00918528 Phase 1, Phase 2 Mitomycin C - local injection
5 Effectiveness and Safety of Autologous Adipose-Derived Regenerative Cells for the Treatment of Urethral Strictures Unknown status NCT01889888 Phase 1, Phase 2
6 Role of Uttarbasti in the Management of Mutra Marga Sankoch (Urethral Stricture) Completed NCT00535717 Phase 2
7 Clostridium Histolyticum Collagenase Injection for Urethral Disease Not yet recruiting NCT02948842 Phase 2 Clostridium Histolyticum Collagenase;Lidocaine
8 A Safety Evaluation of Renal Denervation Using Focused Therapeutic Ultrasound on Patients With Refractory Hypertension Completed NCT01638195 Phase 1
9 Safety and Feasibility Study of Autologous Engineered Urethral Constructs for the Treatment of Strictures Not yet recruiting NCT03258658 Phase 1
10 Liquid Buccal Mucosa Graft Urethroplasty Not yet recruiting NCT03061344 Phase 1
11 Hemostasis During Hypospadias Surgery Unknown status NCT02268019 Not Applicable epinephrine injection
12 The Improvement in Uroflow and Postvoid Residual Urine After Urethral Meatotomy in Children With Meatal Stenosis Unknown status NCT01214525
13 PVP Compared to TURP for the Treatment of Benign Hyperplasia of the Prostate Completed NCT00527371 Not Applicable
14 Re-establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease Recruiting NCT03270384 Not Applicable
15 A Study of Dorsal Versus Ventral Buccal Mucosa Graft Onlay for Bulbar Urethroplasty Recruiting NCT02634619 Not Applicable
16 Tissue-engineered Construct Based on Buccal Mucosa Cells and Matrix From Collagen and Polylactoglycolide Fibers Recruiting NCT03205670 Early Phase 1
17 Functional Outcome of Urethral Reconstructive Surgery Recruiting NCT01982136
18 Dorsal vs. Ventral Buccal Graft Dorsal vs. Ventral Buccal Graft Recruiting NCT02551783 Not Applicable
19 Scandinavian Urethroplasty Study Recruiting NCT02321670 Not Applicable
20 Effect of Caudal and Penile Block on Hypospadias Repair Complications Recruiting NCT02851290 Not Applicable
21 A Prospective Evaluation of the Catheter Science M3 "Mini Catheter" for Patients With Prostatic Recruiting NCT03339076 Not Applicable
22 ROBUST I Pilot Study Active, not recruiting NCT03014726 Not Applicable
23 Prophylactic Antibiotics or Placebo After Hypospadias Repair Active, not recruiting NCT02096159 Not Applicable trimethoprim-sulfamethoxazole
24 ROBUST III- Re-Establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease Not yet recruiting NCT03499964 Not Applicable
25 VeSpAR: Comparing Vessel-Sparing Anastomotic Repair and Transecting Anastomotic Repair in Isolated Short Bulbar Strictures. Not yet recruiting NCT03572348 Not Applicable
26 Transgender Post-reassignment Urogynecologic Measures and Perceptions Not yet recruiting NCT03293771
27 Comparison of Different Energy Sources During TUR-P Not yet recruiting NCT02533687 Not Applicable
28 Primary Urethral Realignment vs. Suprapubic Cystostomy for Initial Management of Pediatric Pelvic Fracture Urethral Injury Not yet recruiting NCT03468387 Not Applicable

Search NIH Clinical Center for Urethral Stricture

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Genetic Tests for Urethral Stricture

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Anatomical Context for Urethral Stricture

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MalaCards organs/tissues related to Urethral Stricture:

41
Prostate, Skin, Kidney, Spinal Cord, Colon, Small Intestine, Brain
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Publications for Urethral Stricture

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Articles related to Urethral Stricture:

(show top 50) (show all 670)
# Title Authors Year
1
Refractory Urethral Stricture Management: Indications for Alternative Grafts and Flaps. ( 29479650 )
2018
2
A case of spontaneous urinary bladder rupture secondary to urinary retention due to an urethral stricture. ( 29541588 )
2018
3
Management of long segment anterior urethral stricture (a8Y 8cm) using buccal mucosal (BM) graft and penile skin (PS) flap: outcome and predictors of failure. ( 29211404 )
2018
4
Endoscopic Management of Urethral Stricture: Review and Practice Algorithm for Management of Male Urethral Stricture Disease. ( 29479640 )
2018
5
Re: Repair of pan-urethral stricture: Proximal ventral and distal dorsal onlay technique of buccal mucosal graft urethroplasty. By Subbarao Chodisetti, Yogesh Boddepalli, Malakondareddy Kota. ( 29892485 )
2018
6
A novel heterozygous GLI2 mutation in a patient with congenital urethral stricture and renal hypoplasia/dysplasia leading to end-stage renal failure. ( 29318530 )
2018
7
Re: Urethral Stricture Outcomes after Artificial Urinary Sphincter Cuff Erosion: Results from a Multicenter Retrospective Analysis. ( 29357550 )
2018
8
Re: Low Testosterone Levels Result in Decreased Periurethral Vascularity via an Androgen Receptor-Mediated Process: Pilot Study in Urethral Stricture Tissue. ( 29357549 )
2018
9
Hypoandrogenism is Prevalent in Males with Urethral Stricture Disease and is Associated with Longer Strictures. ( 29378279 )
2018
10
Long term follow up of proximal hypospadias repair-urethral stricture should be excluded in adults who present with epididymo-orchitis. ( 29511587 )
2018
11
Long-term Effect of Colchicine Treatment in Preventing Urethral Stricture Recurrence After Internal Urethrotomy. ( 29681046 )
2018
12
microRNA expression profiles of scar and normal tissue from patients with posterior urethral stricture caused by pelvic fracture urethral distraction defects. ( 29436608 )
2018
13
An Experimental Model of Anterior Urethral Stricture in Rabbits With Local Injections of Bleomycin. ( 29545036 )
2018
14
Ejaculatory Disorders in Men With Urethral Stricture and Impact of Urethroplasty on the Ejaculatory Function: A Systematic Review. ( 29960631 )
2018
15
A Simplified Adult Acquired Buried Penis Repair Classification System with an Analysis of Perioperative Complications and Urethral Stricture Disease<sup>,,a9^a9^a9^</sup>. ( 29898381 )
2018
16
Re: The International Prostate Symptom Score (IPSS) is an Inadequate Tool toA Screen for Urethral Stricture Recurrence after Anterior Urethroplasty. ( 29539918 )
2017
17
Management of bladder neck stenosis and urethral stricture and stenosis following treatment for prostate cancer. ( 28791228 )
2017
18
Incidence and predictors of complications due to urethral stricture in patients awaiting urethroplasty. ( 28899769 )
2017
19
Definition of Successful Treatment and Optimal Follow-up after Urethral Reconstruction for Urethral Stricture Disease. ( 27908363 )
2017
20
Substitution urethroplasty for anterior urethral stricture repair: comparison between lingual mucosa graft and pedicled skin flap. ( 28738760 )
2017
21
Double inlay plus ventral onlay buccal mucosa graft for simultaneous penile and bulbar urethral stricture. ( 29135409 )
2017
22
The predictive value of platelet to lymphocyte and neutrophil to lymphocyte ratio in determining urethral stricture after transurethral resection of prostate. ( 28861306 )
2017
23
Three-Dimensional Computerized Model Based on the Sonourethrogram: A Novel Technique for Evaluating the Anterior Urethral Stricture. ( 28866465 )
2017
24
Anastomotic Urethroplasty for an Obstructing Calculus Within a Bulbar Urethral Diverticulum and Urethral Stricture. ( 27981035 )
2017
25
Understanding patients' preferences for surgical management of urethral stricture disease. ( 28664240 )
2017
26
Management of Urethral Stricture and Bladder Neck Contracture Following Primary and Salvage Treatment of Prostate Cancer. ( 28776126 )
2017
27
Delayed primary end-to-end anastomosis for traumatic long segment urethral stricture and its short-term outcomes. ( 29487268 )
2017
28
Fulfilling Patient Expectations of Urethral Stricture Surgery. ( 28822234 )
2017
29
AT<sub>1</sub>expression in human urethral stricture tissue. ( 28979891 )
2017
30
Editorial Comment to Substitution urethroplasty using oral mucosa graft for male anterior urethral stricture disease: Current topics and reviews. ( 28626935 )
2017
31
A novel method in decision making for the diagnosis of anterior urethral stricture: using methylene blue dye. ( 29201515 )
2017
32
Re: Analysis of Risk Factors Leading to Postoperative Urethral Stricture and Bladder Neck Contracture following Transurethral Resection of Prostate. ( 28905747 )
2017
33
Initial experience with Alliuma8c stent in the management of bulbar urethral stricture. ( 28791227 )
2017
34
Squamous Cell Carcinoma Penis in a Case of Urethral Stricture Due to Lichen Sclerosus Balanitis Xerotica Obliterans: A Case Report and Review of Literature. ( 28892974 )
2017
35
Ventral-onlay buccal mucosa graft substitution urethroplasty for urethral stricture in women. ( 28749039 )
2017
36
Management of urethral stricture: High-pressure balloon dilation versus optical internal urethrotomy. ( 29119701 )
2017
37
Comparison of Diagnostic Value of Sonourethrography with Retrograde Urethrography in Diagnosis of Anterior Urethral Stricture. ( 28698753 )
2017
38
Re: Incidence of Urethral Stricture in Patients with Spinal Cord Injury Treated with Clean Intermittent Self-Catheterization. ( 28905775 )
2017
39
Re: Outcomes for Management of Lichen Sclerosus Urethral Strictures by 3 Different Techniques. ( 29370640 )
2017
40
Re: Outpatient Ultrasound Urethrogram for Assessment of Anterior Urethral Stricture: Early Experience. ( 27979534 )
2017
41
Re: Comprehensive Qualitative Assessment of Urethral Stricture Disease: Toward the Development of a Patient Centered Outcome Measure. ( 28890244 )
2017
42
Substitution urethroplasty using oral mucosa graft for male anterior urethral stricture disease: Current topics and reviews. ( 28600871 )
2017
43
Cost-effective Strategies for the Management and Treatment of Urethral Stricture Disease. ( 27908365 )
2017
44
Urethroplasty and Quality of Life: Psychometric Validation of a Dutch Version of the Urethral Stricture Surgery Patient Reported Outcome Measures. ( 28850951 )
2017
45
A 10-Year Review of Urethral Stricture Management in Irrua, Nigeria. ( 29089737 )
2017
46
Incidence and Management of Lower Urinary Tract Symptoms After Urethral Stricture Repair. ( 28718163 )
2017
47
Anti-fibrotic function of Cu-bearing stainless steel for reducing recurrence of urethral stricture after stent implantation. ( 29068537 )
2017
48
Re: Cultural background, non-therapeutic circumcision and the risk of meatal stenosis and other urethral stricture disease: Two nationwide register-based cohort studies in Denmark 1977-2013. ( 28869139 )
2017
49
Bulbar urethral stricture: How to optimise the use of buccal mucosal grafts. ( 27489734 )
2016
50
Metastatic Malignant Melanoma of the Urinary Bladder in a Patient With Benign Prostatic Hyperplasia and Urethral Stricture. ( 27491496 )
2016
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Variations for Urethral Stricture

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Expression for Urethral Stricture

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Search GEO for disease gene expression data for Urethral Stricture.
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Pathways for Urethral Stricture

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Pathways related to Urethral Stricture according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Adhesion 4
10.89 CTGF KLK3 SIRPA
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GO Terms for Urethral Stricture

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Biological processes related to Urethral Stricture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fibroblast growth factor receptor signaling pathway GO:0008543 9.16 CTGF FAT4
2 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 8.96 FAT4 SCARF1
3 cell adhesion GO:0007155 8.92 CTGF FAT4 SCARF1 SIRPA
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Sources for Urethral Stricture

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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