MCID: URT037
MIFTS: 34

Urethral Stricture

Categories: Nephrological diseases

Aliases & Classifications for Urethral Stricture

MalaCards integrated aliases for Urethral Stricture:

Name: Urethral Stricture 12 56 45 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:1829
ICD9CM 36 598.8
MeSH 45 D014525
ICD10 34 N35

Summaries for Urethral Stricture

MalaCards based summary : Urethral Stricture is related to urethral syndrome and urinary tract obstruction. An important gene associated with Urethral Stricture is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways is Adhesion. The drugs Acetaminophen and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and prostate.

Wikipedia : 77 A urethral stricture is a narrowing of the urethra caused by injury, instrumentation, infection, and... more...

Related Diseases for Urethral Stricture

Diseases related to Urethral Stricture via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 urethral syndrome 32.5 KLK3 MYZAP
2 urinary tract obstruction 30.1 CCN2 KLK3
3 infective urethral stricture 12.3
4 pigmentary disorder, reticulate, with systemic manifestations, x-linked 11.3
5 hypospadias 10.6
6 lichen sclerosus 10.6
7 prostate cancer 10.3
8 prostate cancer, hereditary, 8 10.3
9 prostate cancer, hereditary, 6 10.3
10 impotence 10.3
11 prostatic hyperplasia, benign 10.3
12 balanitis 10.3
13 balanitis xerotica obliterans 10.3
14 leukoplakia of penis 10.3
15 urethritis 10.2
16 posterior urethral valves 10.2
17 cystitis 10.2
18 squamous cell carcinoma 10.2
19 prostatic adenoma 10.2
20 spinal cord injury 10.1
21 sensory peripheral neuropathy 10.1
22 neuropathy 10.1
23 eosinophilic cystitis 10.1
24 prostatic cyst 10.1 BCL2L10 KLK3
25 bladder neck obstruction 10.0 KLK3 SIRPA
26 horns in sheep 9.9
27 brain injury 9.9
28 end stage renal failure 9.9
29 gas gangrene 9.9
30 hemangioma 9.9
31 sexual disorder 9.9
32 renal hypoplasia 9.9
33 malignant hypertension 9.9
34 conn's syndrome 9.9
35 acute cystitis 9.9
36 schistosomiasis 9.9
37 prostatitis 9.9
38 lymphangioma 9.9
39 melanoma 9.9
40 orchitis 9.9
41 epidermolysis bullosa 9.9
42 anuria 9.9
43 junctional epidermolysis bullosa 9.9
44 ischemia 9.9
45 urethra squamous cell carcinoma 9.9
46 spindle cell carcinoma 9.9
47 primary syphilis 9.9
48 syphilis 9.9
49 amyloidosis 9.9
50 priapism 9.9

Comorbidity relations with Urethral Stricture via Phenotypic Disease Network (PDN): (show all 27)


Acute Cystitis Acute Kidney Failure
Balanoposthitis Bladder Cancer
Bladder Neck Obstruction Chronic Kidney Failure
Chronic Myocardial Ischemia Cystitis
Cystitis Cystica Deficiency Anemia
Epididymo-Orchitis Hydronephrosis
Ischemic Heart Disease Nephrolithiasis, X-Linked Recessive, with Renal Failure
Neurogenic Bladder Peyronie's Disease
Prostate Calculus Prostate Cancer
Prostatic Hypertrophy Prostatitis
Radiation Cystitis Trigonitis
Ureterolithiasis Urethral Calculus
Urethral Gland Abscess Urethritis
Urinary Tract Obstruction

Graphical network of the top 20 diseases related to Urethral Stricture:



Diseases related to Urethral Stricture

Symptoms & Phenotypes for Urethral Stricture

Drugs & Therapeutics for Urethral Stricture

Drugs for Urethral Stricture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 88)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4 103-90-2 1983
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
3
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
4
Ibuprofen Approved Phase 4 15687-27-1 3672
5
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
6
Bupivacaine Approved, Investigational Phase 4,Phase 3 38396-39-3, 2180-92-9 2474
7
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
8
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
9
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
10
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
11 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
12 Autonomic Agents Phase 4,Not Applicable
13 Neurotransmitter Agents Phase 4,Not Applicable
14 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
15 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
16 Analgesics, Opioid Phase 4
17 Antineoplastic Agents, Hormonal Phase 4
18 Analgesics Phase 4
19 Tranquilizing Agents Phase 4
20 Excitatory Amino Acids Phase 4
21 Cyclooxygenase Inhibitors Phase 4
22 Psychotropic Drugs Phase 4
23 Anticonvulsants Phase 4
24 Excitatory Amino Acid Antagonists Phase 4
25 Hormones Phase 4
26 Antiemetics Phase 4
27 Gastrointestinal Agents Phase 4
28
protease inhibitors Phase 4
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
30 HIV Protease Inhibitors Phase 4
31 Antirheumatic Agents Phase 4
32 Anesthetics, Local Phase 4,Phase 3,Phase 2,Not Applicable
33 Anti-Anxiety Agents Phase 4
34 glucocorticoids Phase 4
35 Antimanic Agents Phase 4
36 Narcotics Phase 4
37 Cyclooxygenase 2 Inhibitors Phase 4
38 Anti-Inflammatory Agents Phase 4
39 Analgesics, Non-Narcotic Phase 4
40 Anti-Inflammatory Agents, Non-Steroidal Phase 4
41 Hormone Antagonists Phase 4
42 Antipyretics Phase 4
43 BB 1101 Phase 4
44 Pharmaceutical Solutions Phase 3
45 Anti-Bacterial Agents Phase 1, Phase 2,Not Applicable
46 Antibiotics, Antitubercular Phase 1, Phase 2,Not Applicable
47 Alkylating Agents Phase 1, Phase 2
48 Nucleic Acid Synthesis Inhibitors Phase 1, Phase 2
49 Mitomycins Phase 1, Phase 2
50 Anti-Arrhythmia Agents Phase 2

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 Efficiency of Cold vs. Laser Internal Urethrotomy Treatment of Urethral Strictures Unknown status NCT01196572 Phase 4
2 Efficacy of Opioid-limiting Pain Management Protocol in Men Undergoing Urethroplasty Recruiting NCT03859024 Phase 4 Oxycodone;Acetaminophen;Gabapentin;celebrex;Bupivacaine;Ibuprofen 800 mg;Dexamethasone
3 The Effect of Preemptive Analgesia On The Comfort Of Patient and Doctor, in Cystoscopy Recruiting NCT03831321 Phase 4 Diclofenac Sodium;Lubricant Gel
4 Diagnosis of Urethral Stricture With Sono-urethrography vs Conventional Urethrography (SONO-URETHRA) Unknown status NCT01790776 Phase 3
5 Memokath® 044TW Stent for Treatment of Urethral Stricture Completed NCT00270504 Phase 3
6 Liposomal Bupivacaine To Control Post-Operative Pain Following BMG Active, not recruiting NCT03720223 Phase 3 Liposomal Bupivacaine
7 Effect of Mitomycin C on Urethral Stricture Recurrence After Internal Urethrotomy Unknown status NCT00918528 Phase 1, Phase 2 Mitomycin C - local injection
8 Effectiveness and Safety of Autologous Adipose-Derived Regenerative Cells for the Treatment of Urethral Strictures Unknown status NCT01889888 Phase 1, Phase 2
9 Role of Uttarbasti in the Management of Mutra Marga Sankoch (Urethral Stricture) Completed NCT00535717 Phase 2
10 Clostridium Histolyticum Collagenase Injection for Urethral Disease Not yet recruiting NCT02948842 Phase 2 Clostridium Histolyticum Collagenase;Lidocaine
11 A Safety Evaluation of Renal Denervation Using Focused Therapeutic Ultrasound on Patients With Refractory Hypertension Completed NCT01638195 Phase 1
12 Liquid Buccal Mucosa Graft Urethroplasty Not yet recruiting NCT03061344 Phase 1
13 Safety and Feasibility Study of Autologous Engineered Urethral Constructs for the Treatment of Strictures Suspended NCT03258658 Phase 1
14 Hemostasis During Hypospadias Surgery Unknown status NCT02268019 Not Applicable epinephrine injection
15 Comparison of Different Energy Sources During TUR-P Unknown status NCT02533687 Not Applicable
16 PVP Compared to TURP for the Treatment of Benign Hyperplasia of the Prostate Completed NCT00527371 Not Applicable
17 ROBUST III- Re-Establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease Recruiting NCT03499964 Not Applicable
18 Functional Outcome of Urethral Reconstructive Surgery Recruiting NCT01982136
19 VeSpAR: Comparing Vessel-Sparing Anastomotic Repair and Transecting Anastomotic Repair in Isolated Short Bulbar Strictures. Recruiting NCT03572348 Not Applicable
20 Dorsal vs. Ventral Buccal Graft Dorsal vs. Ventral Buccal Graft Recruiting NCT02551783 Not Applicable
21 Scandinavian Urethroplasty Study Recruiting NCT02321670 Not Applicable
22 ProACT Post-Approval Study Recruiting NCT03767595 Not Applicable
23 Effect of Caudal and Penile Block on Hypospadias Repair Complications Recruiting NCT02851290 Not Applicable
24 A Prospective Evaluation of the Catheter Science M3 "Mini Catheter" for Patients With Prostatic Recruiting NCT03339076 Not Applicable
25 Transgender Post-reassignment Urogynecologic Measures and Perceptions Recruiting NCT03293771
26 Re-establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease Active, not recruiting NCT03270384 Not Applicable
27 ROBUST I Pilot Study Active, not recruiting NCT03014726 Not Applicable
28 Prophylactic Antibiotics or Placebo After Hypospadias Repair Active, not recruiting NCT02096159 Not Applicable trimethoprim-sulfamethoxazole
29 Bipolar Plasmakinetic TURP Versus Monopolar TURP in the Treatment of Lower Urinary Tract Symptoms (LUTS) Due to Benign Prostatic Hyperplasia (BPH) Active, not recruiting NCT03936244 Not Applicable
30 Tissue-engineered Construct Based on Buccal Mucosa Cells and Matrix From Collagen and Polylactoglycolide Fibers Enrolling by invitation NCT03205670 Early Phase 1
31 Re-Establishing Flow Via Drug Coated Balloon for the Treatment of Urethral Stricture Disease - Registry Study Not yet recruiting NCT03851952 Not Applicable
32 TREatment of Uretral STRICTure With Self-catheterization : Tolerance Evaluation Not yet recruiting NCT03948009
33 Waterjet Prostate Ablation Not yet recruiting NCT03938194 Not Applicable
34 Primary Urethral Realignment vs. Suprapubic Cystostomy for Initial Management of Pediatric Pelvic Fracture Urethral Injury Not yet recruiting NCT03468387 Not Applicable
35 A Study of Dorsal Versus Ventral Buccal Mucosa Graft Onlay for Bulbar Urethroplasty Terminated NCT02634619 Not Applicable

Search NIH Clinical Center for Urethral Stricture

Cochrane evidence based reviews: urethral stricture

Genetic Tests for Urethral Stricture

Anatomical Context for Urethral Stricture

MalaCards organs/tissues related to Urethral Stricture:

42
Skin, Spinal Cord, Prostate, Kidney, Colon, Small Intestine, Brain

Publications for Urethral Stricture

Articles related to Urethral Stricture:

(show top 50) (show all 778)
# Title Authors Year
1
Insights into the Pathophysiology of Urethral Stricture Disease Due to Lichen Sclerosus: Comparison of Pathological Markers in Lichen Sclerosus Induced Strictures vs Nonlichen Sclerosus Induced Strictures. ( 30835614 )
2019
2
Management of urethral stricture: High-pressure balloon dilation versus optical internal urethrotomy. ( 29119701 )
2019
3
Population Analysis of Male Urethral Stricture Management and Urethroplasty Success in the United States. ( 30170091 )
2019
4
Buccal epithelium Expanded and Encapsulated in Scaffold-Hybrid Approach to Urethral Stricture (BEES-HAUS) procedure: A novel cell therapy-based pilot study. ( 30468021 )
2019
5
Editorial Comment from Dr Horiguchi to Buccal epithelium Expanded and Encapsulated in Scaffold-Hybrid Approach to Urethral Stricture (BEES-HAUS) procedure: A novel cell therapy-based pilot study. ( 30485905 )
2019
6
Editorial Comment from Dr Takao to Buccal epithelium Expanded and Encapsulated in Scaffold-Hybrid Approach to Urethral Stricture (BEES-HAUS) procedure: A novel cell therapy-based pilot study. ( 30556177 )
2019
7
Gel-Infused Translabial Ultrasound in the Evaluation of Female Urethral Stricture. ( 30664026 )
2019
8
Urinary and Sexual Function after Perineal Urethrostomy for Urethral Stricture Disease: An Analysis from the TURNS. ( 30676476 )
2019
9
Urethral stricture after bipolar transurethral resection of prostate - truth vs hype: A randomized controlled trial. ( 30692723 )
2019
10
Clinical significance of cystoscopic urethral stricture recurrence after anterior urethroplasty: a multi-institution analysis from Trauma and Urologic Reconstructive Network of Surgeons (TURNS). ( 30712091 )
2019
11
Socioeconomic and patient-related factors for the management of male urethral stricture disease. ( 30810835 )
2019
12
Effect of preoperative urethral dilatation on preventing urethral stricture after holmium laser enucleation of the prostate: A randomized controlled study. ( 30817290 )
2019
13
Case of wide calibre false urethral passage in a patient of urethral stricture. ( 30826787 )
2019
14
Is minimal invasive technique harmful in treatment of urethral stricture? ( 30837431 )
2019
15
Multiple Urethral Hemangiomas Associated with Urethral Stricture: An Uncommon Aetiology for Urethral Bleeding. ( 30863652 )
2019
16
Reconstruction of the urethra with an anterior vaginal mucosal flap in female urethral stricture. ( 30877352 )
2019
17
Trends in Urethral Stricture Disease Etiology and Urethroplasty Technique from a Multi-Institutional Surgical Outcomes Research Group. ( 30880075 )
2019
18
Comparison between cold knife and laser urethrotomy for urethral stricture: a systematic review and meta-analysis of comparative trials. ( 30895360 )
2019
19
Female Urethroplasty: A Practical Guide Emphasizing Diagnosis and Surgical Treatment of Female Urethral Stricture Disease. ( 30906779 )
2019
20
Re: A Simplified Adult Acquired Buried Penis Repair Classification System with an Analysis of Perioperative Complications and Urethral Stricture Disease. ( 30932771 )
2019
21
Penile skin flap: a versatile substitute for anterior urethral stricture. ( 31038860 )
2019
22
Substitution urethroplasty for the treatment of male urethral stricture: Outcomes in an Australian center. ( 31064032 )
2019
23
Male urethral stricture disease in a regional centre: 10 years of experience. ( 31083791 )
2019
24
Outcome of staged buccal mucosal graft for repair of long segment anterior urethral stricture. ( 31096965 )
2019
25
A novel heterozygous GLI2 mutation in a patient with congenital urethral stricture and renal hypoplasia/dysplasia leading to end-stage renal failure. ( 29318530 )
2018
26
Long term follow up of proximal hypospadias repair-urethral stricture should be excluded in adults who present with epididymo-orchitis. ( 29511587 )
2018
27
Retroperitoneal necrotizing fasciitis with gas gangrene caused by urethral stricture. ( 29984183 )
2018
28
Anti-fibrotic function of Cu-bearing stainless steel for reducing recurrence of urethral stricture after stent implantation. ( 29068537 )
2018
29
Double inlay plus ventral onlay buccal mucosa graft for simultaneous penile and bulbar urethral stricture. ( 29135409 )
2018
30
Management of long segment anterior urethral stricture (≥ 8cm) using buccal mucosal (BM) graft and penile skin (PS) flap: outcome and predictors of failure. ( 29211404 )
2018
31
Re: Low Testosterone Levels Result in Decreased Periurethral Vascularity via an Androgen Receptor-Mediated Process: Pilot Study in Urethral Stricture Tissue. ( 29357549 )
2018
32
Re: Urethral Stricture Outcomes after Artificial Urinary Sphincter Cuff Erosion: Results from a Multicenter Retrospective Analysis. ( 29357550 )
2018
33
Hypoandrogenism is Prevalent in Males With Urethral Stricture Disease and is Associated with Longer Strictures. ( 29378279 )
2018
34
microRNA expression profiles of scar and normal tissue from patients with posterior urethral stricture caused by pelvic fracture urethral distraction defects. ( 29436608 )
2018
35
Endoscopic Management of Urethral Stricture: Review and Practice Algorithm for Management of Male Urethral Stricture Disease. ( 29479640 )
2018
36
Refractory Urethral Stricture Management: Indications for Alternative Grafts and Flaps. ( 29479650 )
2018
37
A case of spontaneous urinary bladder rupture secondary to urinary retention due to an urethral stricture. ( 29541588 )
2018
38
An Experimental Model of Anterior Urethral Stricture in Rabbits With Local Injections of Bleomycin. ( 29545036 )
2018
39
Long-term Effect of Colchicine Treatment in Preventing Urethral Stricture Recurrence After Internal Urethrotomy. ( 29681046 )
2018
40
Re: Repair of pan-urethral stricture: Proximal ventral and distal dorsal onlay technique of buccal mucosal graft urethroplasty. By Subbarao Chodisetti, Yogesh Boddepalli, Malakondareddy Kota. ( 29892485 )
2018
41
A Simplified Adult Acquired Buried Penis Repair Classification System With an Analysis of Perioperative Complications and Urethral Stricture Disease. ( 29898381 )
2018
42
Ejaculatory Disorders in Men With Urethral Stricture and Impact of Urethroplasty on the Ejaculatory Function: A Systematic Review. ( 29960631 )
2018
43
Validated uroflowmetry-based predictive model for the primary diagnosis of urethral stricture disease in men. ( 30021245 )
2018
44
Editorial Comment to Validated uroflowmetry-based predictive model for the primary diagnosis of urethral stricture disease in men. ( 30066428 )
2018
45
Penile fasciocutaneous flap urethroplasty for the reconstruction of pediatric long anterior urethral stricture. ( 30131215 )
2018
46
miR-21 modification enhances the performance of adipose tissue-derived mesenchymal stem cells for counteracting urethral stricture formation. ( 30179296 )
2018
47
International volunteerism and urethral stricture disease: a review. ( 30211056 )
2018
48
U-score system for predicting time to recurrence after urethral reconstruction in patients with anterior urethral stricture. ( 30221414 )
2018
49
Prevalence and surgical management of concurrent adult acquired buried penis and urethral stricture disease. ( 30298286 )
2018
50
Familial Urethral Stricture, Five Adult patients overview. ( 30318567 )
2018

Variations for Urethral Stricture

Expression for Urethral Stricture

Search GEO for disease gene expression data for Urethral Stricture.

Pathways for Urethral Stricture

Pathways related to Urethral Stricture according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.89 CCN2 KLK3 SIRPA

GO Terms for Urethral Stricture

Sources for Urethral Stricture

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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