MCID: URT004
MIFTS: 39

Urethral Syndrome

Categories: Nephrological diseases, Reproductive diseases

Aliases & Classifications for Urethral Syndrome

MalaCards integrated aliases for Urethral Syndrome:

Name: Urethral Syndrome 12 15 70
Urethral Disease 12 15 17
Urethral Diseases 44 70
Abnormality of the Urethra 29
Urethral Disorders 42
Urethra Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13498 DOID:732
ICD9CM 34 597.81
MeSH 44 D014522
NCIt 50 C26903
SNOMED-CT 67 31273004 4985009
UMLS 70 C0041969 C0156279

Summaries for Urethral Syndrome

MedlinePlus : 42 The urethra is the tube that allows urine to pass out of the body. In men, it's a long tube that runs through the penis. It also carries semen in men. In women, it's short and is just above the vagina. Urethral problems may happen due to aging, illness, or injury. They include Urethral cancer - a rare cancer that happens more often in men Urethral stricture - a narrowing of the opening of the urethra Urethritis - inflammation of the urethra, sometimes caused by infection Urethral problems may cause pain or difficulty passing urine. You may also have bleeding or discharge from the urethra. Doctors diagnose urethral problems using different tests. These include urine tests, x-rays and an examination of the urethra with a scope called a cystoscope. Treatment depends on the cause of the problem. It may include medicines and, in severe cases, surgery.

MalaCards based summary : Urethral Syndrome, also known as urethral disease, is related to urethritis and pyuria, and has symptoms including pain in urethra An important gene associated with Urethral Syndrome is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways is Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Lidocaine and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include urethra, skin and bone.

Disease Ontology : 12 A urinary system disease that is located in the urethra.

Wikipedia : 73 Urethral syndrome is characterised by a set of symptoms typically associated with lower urinary tract... more...

Related Diseases for Urethral Syndrome

Diseases related to Urethral Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 342)
# Related Disease Score Top Affiliating Genes
1 urethritis 30.9 MTRR KLK3 IL6 EPPIN CXCL8 CD4
2 pyuria 30.8 KLK3 IL6 CXCL8
3 bacteriuria 30.7 IL6 H2AC18 CXCL8
4 cystitis 30.6 TAC1 P2RX3 NGF KRT20 IL6 CXCL8
5 prostatitis 30.6 PCA3 KLK3 IL6 CXCL8
6 interstitial cystitis 30.5 TAC1 P2RX3 NGF IL6 CXCL8
7 fibromyalgia 30.3 NGF IL6 CXCL8
8 bladder neck obstruction 30.3 TAC1 KLK3
9 urethral diverticulum 30.2 MCU KLK3 AMACR
10 detrusor sphincter dyssynergia 30.2 TAC1 P2RX3 NGF
11 vaginitis 30.2 IL6 EPPIN CXCL8 CD4 CCR6
12 vaginal discharge 30.1 IL6 CXCL8 CD4
13 neurogenic bladder 30.1 TAC1 P2RX3 NGF KLK3
14 acute cystitis 30.0 KLK3 IL6 H2AC18 CXCL8 CD4 CCR6
15 trichomoniasis 29.9 IL6 EPPIN CXCL8 CD4
16 somatoform disorder 29.9 TAC1 P2RX3 NGF LAPTM4A IL6 H2AC18
17 orchitis 29.8 IL6 H2AC18 EPPIN CD4
18 male urethral cancer 10.5 KLK3 AMACR
19 idiopathic anterior uveitis 10.5 IL6 CXCL8
20 streptococcal toxic-shock syndrome 10.5 IL6 CXCL8
21 acute transverse myelitis 10.5 IL6 CXCL8
22 acute gonococcal cervicitis 10.4 IL6 CXCL8
23 urethral calculus 10.4 MCU KLK3
24 cystitis cystica 10.4 KRT20 KLK3
25 urethra adenocarcinoma 10.4 KLK3 AMACR
26 atrophic vulva 10.4 SHBG KRT20
27 fuchs' heterochromic uveitis 10.4 IL6 CXCL8
28 wolffian duct adenoma 10.4 KLK3 AMACR
29 urethra cancer 10.4 KLK3 AMACR
30 bladder benign neoplasm 10.4 KRT20 AMACR
31 keratoconjunctivitis 10.4 NGF IL6 CXCL8
32 nephrogenic adenoma of urinary bladder 10.4 KRT20 AMACR
33 patellofemoral pain syndrome 10.4 TAC1 LAPTM4A
34 facial neuralgia 10.4 TAC1 LAPTM4A
35 recurrent corneal erosion 10.4 TAC1 IL6 CXCL8
36 prostatic cyst 10.4 KLK3 EPPIN
37 prurigo nodularis 10.4 TAC1 NGF
38 myofascial pain syndrome 10.4 TAC1 NGF LAPTM4A
39 bursitis 10.4 TAC1 LAPTM4A IL6
40 adenomyosis 10.4 NGF IL6 CXCL8
41 endometrial disease 10.4 SIGLEC5 IL6 CXCL8
42 algoneurodystrophy 10.4 TAC1 NGF
43 female urethral cancer 10.4 KRT20 KLK3 AMACR
44 nerve compression syndrome 10.4 TAC1 NGF IL6
45 aids phobia 10.4 TAC1 CD4
46 nephrogenic adenoma of the urethra 10.4 KRT20 KLK3 AMACR
47 endometritis 10.4 SIGLEC5 IL6 CXCL8
48 bladder lateral wall cancer 10.4 KRT20 KLK3 AMACR
49 urethral benign neoplasm 10.4 KRT20 KLK3 AMACR
50 urethra clear cell adenocarcinoma 10.4 KRT20 KLK3 AMACR

Comorbidity relations with Urethral Syndrome via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Urethral Syndrome:



Diseases related to Urethral Syndrome

Symptoms & Phenotypes for Urethral Syndrome

UMLS symptoms related to Urethral Syndrome:


pain in urethra

Drugs & Therapeutics for Urethral Syndrome

Drugs for Urethral Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
2 Anesthetics Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clostridium Histolyticum Collagenase Injection Treatment for Urethral Disease: a Prospective, Single-center, Open-label Study Not yet recruiting NCT02948842 Phase 2 Clostridium Histolyticum Collagenase
2 Impact of Hysterectomy and Supracervical Hysterectomy on Quality of Life, Urinary Incontinence and Urethral Length Recruiting NCT03757975
3 Assessment of the Effectiveness and Ease of Use of DirectVision- a Direct Visualization System for Urinary Catheterization: Results of a Single Center Prospective Study Terminated NCT03066999

Search NIH Clinical Center for Urethral Syndrome

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Propantheline
Propantheline Bromide

Cochrane evidence based reviews: urethral diseases

Genetic Tests for Urethral Syndrome

Genetic tests related to Urethral Syndrome:

# Genetic test Affiliating Genes
1 Abnormality of the Urethra 29

Anatomical Context for Urethral Syndrome

The Foundational Model of Anatomy Ontology organs/tissues related to Urethral Syndrome:

19
Urethra

MalaCards organs/tissues related to Urethral Syndrome:

40
Skin, Bone, Spinal Cord, Eye, Thymus, Prostate, Cervix

Publications for Urethral Syndrome

Articles related to Urethral Syndrome:

(show top 50) (show all 309)
# Title Authors PMID Year
1
Clinical presentation of asymptomatic and symptomatic heterosexual men who tested positive for urethral gonorrhoea at a sexual health clinic in Melbourne, Australia. 42
32641070 2020
2
Ultrasonographic assessment of male anterior urethra. Description of the technique of examination and presentation of major pathologies. 42
32399530 2020
3
Urethral Diverticulum following Polypropylene Mesh Midurethral Slings: A Literature Review. 42
32462011 2020
4
Medical Management of Penile and Urethral Lichen Sclerosus with Topical Clobetasol Improves Long-Term Voiding Symptoms and Quality of Life. 61
32717158 2020
5
Factors associated with repeat genital symptoms among sexually transmitted infection service attendees in South Africa, 2015 - 2016. 61
32880344 2020
6
Gel Casting as an Approach for Tissue Engineering of Multilayered Tubular Structures. 61
32089096 2020
7
Eosinophilic cystitis treated with hydrodistention and complementary methods: Case report. 61
30560799 2018
8
Repair of injured urethras with silk fibroin scaffolds in a rabbit model of onlay urethroplasty. 61
29936989 2018
9
Gonococcal cellulitis: an (un)friendly bite. 61
29549606 2018
10
Urethral lichen sclerosus under the microscope: a survey of academic pathologists. 61
29900821 2018
11
Three-Dimensional Computerized Model Based on the Sonourethrogram: A Novel Technique to Evaluate Anterior Urethral Stricture. 61
28866465 2018
12
Surgical Management of Adult Acquired Buried Penis: Escutcheonectomy, Scrotectomy, and Penile Split-thickness Skin Graft. 61
28779991 2017
13
Initial experience with Allium™ stent in the management of bulbar urethral stricture. 61
28791227 2017
14
Systematic Review to Compare Urothelium Differentiation with Urethral Epithelium Differentiation in Fetal Development, as a Basis for Tissue Engineering of the Male Urethra. 61
27809709 2017
15
Traumatic lesions of the posterior urethra. 61
27174572 2016
16
[Urethral Syndrome and Urethral Pain: Do we Treat People or Diagnoses?]. 61
27500850 2016
17
The application of CT voiding urethrography in the evaluation of urethral stricture associated with fistula: a preliminary report. 61
27146077 2016
18
Female stress urinary incontinence and the mid-urethral sling: is obstruction necessary to achieve dryness? 61
26025190 2015
19
A prospective study to evaluate the efficacy of Cistiquer in improving lower urinary tract symptoms in females with urethral syndrome. 61
25034330 2014
20
Lichen sclerosus and isolated bulbar urethral stricture disease. 61
24657836 2014
21
Distal urethrectomy for localized penile squamous carcinoma in situ extending into the urethra: an updated series. 61
24633698 2014
22
Enigma of urethral pain syndrome: why are there so many ascribed etiologies and therapeutic approaches? 61
24447292 2014
23
Cancer identified incidentally in the prostate following radical cystoprostatectomy: an Australian study. 61
23216652 2014
24
CT virtual cystourethroscopy for complex urethral strictures: an investigative, descriptive study. 61
24307426 2014
25
Correlation between demographic and clinical variables and fibromyalgia severity. 61
24477723 2013
26
Female urethral dilation. 61
23408001 2013
27
Role of routine transurethral biopsy and isolated upper tract cytology after intravesical treatment of high-grade non-muscle invasive bladder cancer. 61
22762480 2012
28
[Three theses on urethral disease]. 61
22710094 2012
29
[Local injection of gentamycin for female urethral syndrome: a clinical study]. 61
21961239 2011
30
Risk factors for male slings: a comparative study of two techniques. 61
21492919 2011
31
The role of a leaky epithelium and potassium in the generation of bladder symptoms in interstitial cystitis/overactive bladder, urethral syndrome, prostatitis and gynaecological chronic pelvic pain. 61
21176078 2011
32
Urinary tract infections in healthy women: a revolution in management? 61
20504297 2010
33
Presentation, pattern, and natural course of severe symptoms, and role of antibiotics and antibiotic resistance among patients presenting with suspected uncomplicated urinary tract infection in primary care: observational study. 61
20139213 2010
34
Approach to urinary tract infections. 61
20535247 2009
35
A randomized comparison of azithromycin and doxycycline for the treatment of Mycoplasma genitalium-positive urethritis in men. 61
19438399 2009
36
Dipsticks and diagnostic algorithms in urinary tract infection: development and validation, randomised trial, economic analysis, observational cohort and qualitative study. 61
19364448 2009
37
Urethrography in the male: the clamp method. 61
19107647 2009
38
[Urethral syndrome in men--chronic pelvic pain syndrome]. 61
19504994 2009
39
Sites of pain from interstitial cystitis/painful bladder syndrome. 61
18707715 2008
40
Fibromyalgia syndrome: presentation, diagnosis, differential diagnosis, and vulnerability. 61
18323767 2008
41
Symptoms of interstitial cystitis, painful bladder syndrome and similar diseases in women: a systematic review. 61
17222607 2007
42
Urethral syndrome: response to alpha-adrenergic blocking agents. 61
16261427 2006
43
[Calcium antagonists in the urethral syndrome of women with urinary incontinence and urgency]. 61
16838613 2006
44
[Diagnosis and treatment of interstitial cystitis: report of 16 misdiagnosed cases]. 61
16620671 2006
45
Treatment of urethral syndrome: a prospective randomized study with Nd:YAG laser. 61
16493214 2006
46
[Comparative observation on therapeutic effects of electroacupuncture and manual acupuncture on female urethral syndrome]. 61
16309090 2005
47
[Antonin Jean Desormeaux]. 61
15751429 2004
48
Contrast-enhanced 3D MR voiding urethrography: preliminary results. 61
15607090 2004
49
Imaging of urethral disease: a pictorial review. 61
15486241 2004
50
[Female prostatitis]. 61
15354532 2004

Variations for Urethral Syndrome

Expression for Urethral Syndrome

Search GEO for disease gene expression data for Urethral Syndrome.

Pathways for Urethral Syndrome

Pathways related to Urethral Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.13 TAC1 NGF IL6 CXCL8

GO Terms for Urethral Syndrome

Cellular components related to Urethral Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 TAC1 SHH NGF KLK3 IL6 EPPIN
2 extracellular region GO:0005576 9.61 TAC1 SHH SHBG NGF KLK3 IL6
3 sperm plasma membrane GO:0097524 8.62 EPPIN CCR6

Biological processes related to Urethral Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium-mediated signaling GO:0019722 9.13 MCU CXCL8 CCR6
2 regulation of T cell migration GO:2000404 8.62 ECM1 CCR6

Sources for Urethral Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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