MCID: URT001
MIFTS: 51

Urethritis

Categories: Nephrological diseases
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Aliases & Classifications for Urethritis

Summaries for Urethritis

MalaCards based summary: Urethritis, also known as nonspecific urethritis, is related to reactive arthritis and urethral syndrome. An important gene associated with Urethritis is DEFA5 (Defensin Alpha 5), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Azithromycin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include prostate, pancreas and spinal cord, and related phenotypes are cardiovascular system and neoplasm

Wikipedia: 75 Urethritis is the inflammation of the urethra. The most common symptoms include painful or difficult... more...

Related Diseases for Urethritis

Diseases related to Urethritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 987)
# Related Disease Score Top Affiliating Genes
1 reactive arthritis 31.9 TNF MRAP HSPD1 CRP
2 urethral syndrome 31.4 TNF MTRR KLK3 IL6 CXCL8 CRP
3 chlamydia 30.8 TNF TLR4 TLR2 IL6 IL1B IL10
4 conjunctivitis 30.7 TNF TLR4 IL6 IL10 CXCL8
5 cystitis 30.7 TNF TLR4 IL6 CXCL8 CRP
6 prostatitis 30.6 TNF KLK3 IL6 IL1B IL10 CXCL8
7 pelvic inflammatory disease 30.6 TLR4 TLR2 HSPD1 CRP
8 chancroid 30.6 HSPD1 CXCL8 CD4
9 haemophilus influenzae 30.6 TNF TLR2 IL1B CXCL8
10 pyuria 30.5 KLK3 IL6 CRP ALB
11 trichomoniasis 30.4 TNF IL6 IL1B IL10 CXCL8 CD4
12 ophthalmia neonatorum 30.4 MTRR MTR CD4
13 cervicitis 30.3 TNF TLR4 TLR2 IL6 IL1B IL10
14 vulvovaginitis 30.3 IL10 HSPD1 CXCL8
15 genital herpes 30.3 TNF TLR2 CD8A CD4
16 interstitial cystitis 30.2 TNF IL6 IL1B
17 epididymo-orchitis 30.2 KLK3 IL6 CRP
18 acute gonococcal cervicitis 30.2 TLR2 IL10 CXCL8
19 trachoma 30.1 TNF IL6 IL10
20 syphilis 30.1 TNF TLR2 CRP CD8A CD4 ALB
21 cat-scratch disease 30.1 HSPD1 CRP CD4
22 primary syphilis 30.0 CD8A CD4
23 anogenital venereal wart 30.0 TNF TLR4 TLR2 IL6 CD8A CD4
24 angina pectoris 29.9 TNF IL6 CRP
25 proctitis 29.9 TNF KLK3 CRP
26 testicular torsion 29.9 TNF IL1B CRP
27 schistosomiasis 29.9 TNF IL10 CRP ALB
28 paine syndrome 29.9 TNF IL6 IL1B IL10 CXCL8
29 stomatitis 29.9 TNF IL6 IL1B IL10 CXCL8 CD4
30 microsporidiosis 29.8 DEFB4A DEFA5 CD8A CD4
31 bacterial vaginosis 29.7 TNF TLR2 IL6 IL1B IL10 DEFB4A
32 granulomatosis with polyangiitis 29.7 TNF CRP CD8A CD4
33 prostatic hypertrophy 29.7 KLK3 CRP ALB
34 neurogenic bladder 29.6 KLK3 CRP ALB
35 shigellosis 29.6 IL1B IL10 CAMP
36 dermatitis 29.6 TNF IL6 IL1B IL10 CXCL8
37 diverticulitis 29.5 TNF IL6 CRP ALB
38 urolithiasis 29.5 IL6 IL1B ALB
39 bacteriuria 29.5 TLR4 TLR2 IL6 CXCL8 CRP ALB
40 endometritis 29.5 TNF TLR4 TLR2 IL6 IL1B CXCL8
41 orchitis 29.4 TNF IL6 IL1B IL10 CRP CD8A
42 synovitis 29.4 TNF IL6 IL1B IL10 CXCL8 CRP
43 candidiasis 29.3 TNF TLR4 TLR2 IL6 IL1B IL10
44 diarrhea 29.3 TNF TLR4 IL6 IL1B IL10 CXCL8
45 urticaria 29.2 TNF IL6 IL1B IL10 CXCL8 CRP
46 spondyloarthropathy 1 29.2 TNF TLR4 MRAP IL6 IL1B IL10
47 tenosynovitis 29.2 TNF IL6 IL1B HSPD1 CRP CD8A
48 acne 29.2 TNF TLR4 TLR2 IL6 IL1B IL10
49 allergic disease 29.1 TNF IL6 IL1B IL10 CXCL8 CD8A
50 salpingitis 29.1 TNF TLR4 TLR2 IL6 IL1B IL10

Comorbidity relations with Urethritis via Phenotypic Disease Network (PDN):


Acute Cystitis Bladder Neck Obstruction
Cystitis Prostate Cancer
Prostatic Hypertrophy Trigonitis
Urethral Stricture

Graphical network of the top 20 diseases related to Urethritis:



Diseases related to Urethritis

Symptoms & Phenotypes for Urethritis

GenomeRNAi Phenotypes related to Urethritis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.17 ALB CAMP CD248 CD4 CD8A CRP
2 no effect GR00402-S-2 10.17 ALB CAMP CD248 CD4 CRP DEFA5

MGI Mouse Phenotypes related to Urethritis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 ALB CRP HSPD1 IL10 IL1B IL6
2 neoplasm MP:0002006 9.97 ALB CD248 IL10 IL1B IL6 TLR2
3 immune system MP:0005387 9.97 ALB CAMP CD248 CD4 CD8A CRP
4 muscle MP:0005369 9.92 ALB HSPD1 IL10 IL6 KLK3 TLR2
5 mortality/aging MP:0010768 9.8 ALB CAMP CD4 CD8A HSPD1 IL10
6 integument MP:0010771 9.36 CD248 CD4 CD8A HSPD1 IL10 IL1B

Drugs & Therapeutics for Urethritis

Drugs for Urethritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 447043
2
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
3
Lymecycline Approved, Investigational Phase 4 992-21-2
4
Tetracycline Approved, Vet_approved, Withdrawn Phase 4 60-54-8 5353990
5 Antibiotics, Antitubercular Phase 4
6 Anti-Bacterial Agents Phase 4
7 Anti-Infective Agents Phase 4
8 Antiprotozoal Agents Phase 4
9 Antiparasitic Agents Phase 4
10 Antimalarials Phase 4
11
Tinidazole Approved, Investigational Phase 2 19387-91-8 5479
12
Icodextrin Approved, Investigational Phase 2 337376-15-5
13
Amdinocillin Investigational, Withdrawn Phase 2 32887-01-7 36273
14 Alkylating Agents Phase 2
15
Racepinephrine Approved, Vet_approved 51-43-4, 329-65-7 838 5816
16
Arginine Approved, Investigational, Nutraceutical 74-79-3 6322
17 Arginine Vasopressin
18 Epinephryl borate
19 Vasopressins
20 Hemostatics
21 Deamino Arginine Vasopressin
22 Coagulants

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Antibiotic Treatment Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
2 Mycoplasma Genitalium Antibiotic Susceptibility and Treatment: A Randomized Double-blind Trial of the Efficacy of Azithromycin and Doxycycline for Clinical and Microbiological Cure of M. Genitalium in Men With Nongonococcal Urethritis Completed NCT00358462 Phase 3 Azithromycin;Doxycycline
3 Phase II Randomized, Placebo-Controlled Double-Blind 4-Arm Trial for the Treatment of Non-Gonococcal Urethritis (NGU): Doxycycline (Plus or Minus Tinidazole) Versus Azithromycin (Plus or Minus Tinidazole) Completed NCT00322465 Phase 2 Tinidazole;Doxycycline;Azithromycin
4 Prospective Study for Cost-Effectiveness Strategies to Improve Partner Notification: Female Trichomonas and Male Urethritis Studies Completed NCT00207467 Phase 2
5 Mecillinam for Treatment of Genital Chlamydia Infection in Asymptomatic Men Terminated NCT02083276 Phase 2 Pivmecillinamhydrochlorid
6 UROGEN WEL-DONE: Can the Novel Rapid Diagnostic UROGEN WELL D-ONE Detect Common Causes of Urinary Tract Infections and Urethritis? Completed NCT04182230
7 Study of the Prevalence of a Chronic Inflammatory Condition of the Male Genital Tract at a Distance and Urethritis Following. Completed NCT01732172
8 Effect of Laser Acupuncture for Treating Monosymptomatic Nocturnal Enuresis in Adolescent Females Recruiting NCT05399173 medical treatment(desmopressin acetate)
9 Impact of a Rapid Test for Gonorrhea and Chlamydia on the Clinical Management of Urethritis and Cervicitis in a Sexual Health Clinic Not yet recruiting NCT05564299
10 Comparison of Current Standard of Care Versus the Australian Guidelines for Management of Mycoplasma Genitalium Infections Among Men Being Treated for Non-gonococcal Urethritis Suspended NCT03910907 Comparison of two standard of care regimens

Search NIH Clinical Center for Urethritis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


ERYTHROMYCIN PWDR

Cochrane evidence based reviews: urethritis

Genetic Tests for Urethritis

Anatomical Context for Urethritis

Organs/tissues related to Urethritis:

MalaCards : Prostate, Pancreas, Spinal Cord, Kidney, Cervix, Lymph Node, Skin

Publications for Urethritis

Articles related to Urethritis:

(show top 50) (show all 4756)
# Title Authors PMID Year
1
Antibodies to Chlamydia trachomatis heat-shock protein 60 kDa and detection of Mycoplasma genitalium and ureaplasma urealyticum are associated independently with chronic nongonococcal urethritis. 53 62
12567170 2003
2
Investigating the microbial pathogens of sexually transmitted infections among heterosexual Vietnamese men with symptomatic urethritis. 62
35416126 2022
3
Meningococcal Urethritis: Old and New. 62
35969045 2022
4
The indications, complications and outcomes of dogs undergoing partial penile amputation: 10 cases (2014-2021). 62
36376076 2022
5
Clinical significance of isolation of Haemophilus no ducreyi in genital samples. Systematic review. 62
36443187 2022
6
Reduction in Rates of Symptomatic Urinary Tract Infection After Pelvic Reconstructive Surgery: A Quality Improvement Analysis. 62
36288115 2022
7
Odynophagia as the first manifestation of toxic epidermal necrolysis. 62
36423938 2022
8
DnaJ, a promising vaccine candidate against Ureaplasma urealyticum infection. 62
36269329 2022
9
Sexuality Transmitted Infection in the COVID-19 Pandemic and Non-Pandemic Time. 62
36412243 2022
10
[Urethritis due to coinfection with Neisseria gonorrhoeae and Enterobius vermicularis in a 27-year-old man]. 62
36333471 2022
11
Corynebacterium glucuronolyticum in men with and without urethritis syndrome: An underrecognized pathogen or a bona fide commensal? 62
36030041 2022
12
Neisseria gonorrhoeae infection in women increases with rising numbers of gonococci in partners: Chlamydia coinfection in women increases gonococcal burden. 62
36201640 2022
13
The Urethral Microbiota of Men with and without Idiopathic Urethritis. 62
36190130 2022
14
[Neisseria meningitidis and the increase of oral sex. A case report]. 62
36307367 2022
15
Vaccinomics-Aided Development of a Next-Generation Chimeric Vaccine against an Emerging Threat: Mycoplasma genitalium. 62
36298585 2022
16
Establishment and application of a CRISPR-Cas12a-based RPA-LFS and fluorescence for the detection of Trichomonas vaginalis. 62
36180879 2022
17
Effectiveness of a behavioural intervention delivered by text messages (safetxt) on sexually transmitted reinfections in people aged 16-24 years: randomised controlled trial. 62
36170988 2022
18
Mycoplasma genitalium screening in a specialized French unit: A retrospective study. 62
35690480 2022
19
Etiological Surveillance of Male Urethritis Syndrome in South Africa: 2019 to 2020. 62
35551168 2022
20
The Incidence Rate of Sexual Behaviors Among Cisgender Men Who Have Sex with Men Attending a Sexual Health Clinic. 62
35930134 2022
21
[Ureteral stenosis following hematopoietic stem cell transplantation: A case report]. 62
35950405 2022
22
MRI in the Evaluation of Locally Advanced Vulvar Cancer Treated with Chemoradiotherapy and Vulvar Cancer Recurrence: The 2021 Revision of FIGO Classification and the Need for Multidisciplinary Management. 62
36010846 2022
23
Disseminated Gonococcal Infection: An Unusual Presentation Resembling a Lupus Flare. 62
36176869 2022
24
In vitro activity of amixicile against T. vaginalis from clinical isolates. 62
35676563 2022
25
Regulation of Host Immune Response against Enterobacter cloacae Proteins via Computational mRNA Vaccine Design through Transcriptional Modification. 62
36014038 2022
26
A Rare Case of Co-Existing Mucin-Producing Urothelial-Type Adenocarcinoma of the Prostate and Acinar Adenocarcinoma. 62
35903905 2022
27
Prevalence of Mycoplasma genitalium and other sexually transmitted pathogens in male urethritis in a sexual health centre in New Caledonia. 62
35621120 2022
28
Catheter-Associated Urinary Tract Infection in Intensive Care Unit Patients at a Tertiary Care Hospital, Hail, Kingdom of Saudi Arabia. 62
35885599 2022
29
[Systematic review and Meta-analysis of efficacy and safety of Ningmitai Capsules in treatment of urinary tract infection]. 62
35850819 2022
30
Impact of the first COVID-19 lockdown on male urethritis syndrome services in South Africa. 62
35790390 2022
31
Infection With the US Neisseria meningitidis Urethritis Clade Does Not Lower Future Risk of Urethral Gonorrhea. 62
34543381 2022
32
Emergence of genital infections due to Haemophilus pittmaniae and Haemophilus sputorum. 62
35483632 2022
33
A dynamic and collaborative approach to trial recruitment in safetxt, a UK sexual health randomised controlled trial. 62
35253453 2022
34
Successful use of tofacitinib in reactive arthritis refractory to conventional therapies - a case series. 62
35024869 2022
35
[Isolation of Neisseria meningitidis in anorectal specimen in a men who have sex with men with uretritis and primary syphilis]. 62
36156697 2022
36
Gonococcal tysonitis, a rare local complication of gonorrhea: a clinical study of 15 cases. 62
35322328 2022
37
Characterization of urethritis-associated Neisseria meningitidis isolated from men who have sex with women in China. 62
35077769 2022
38
Evaluating the utility of the A.F. Genital System test for pathogen diagnosis in acute male urethritis. 62
35064690 2022
39
[A Case of Reactive Arthritis after BCG Intravesical Infusion Therapy Successfully Treated with Salazosulfapyridine]. 62
35748232 2022
40
2021 European guideline on the management of Mycoplasma genitalium infections. 62
35182080 2022
41
Clinical performance of four multiplex real-time PCR kits detecting urogenital and sexually transmitted pathogens. 62
34610459 2022
42
Macrolide-Resistant Mycoplasma genitalium Impairs Clinical Improvement of Male Urethritis After Empirical Treatment. 62
34962241 2022
43
High burden of untreated syphilis, drug resistant Neisseria gonorrhoeae, and other sexually transmitted infections in men with urethral discharge syndrome in Kampala, Uganda. 62
35525934 2022
44
First-Void Urine Microbiome in Women with Chlamydia trachomatis Infection. 62
35628436 2022
45
Detection of Neisseria gonorrhoeae or Chlamydia trachomatis from oral wash specimens using the Abbott RealTime CT/NG assay and the Cobas 4800 CT/NG assay: A prospective study. 62
34930626 2022
46
Risk Factors for Invasive Meningococcal Disease Belonging to a Novel Urethritis Clade of Neisseria meningitidis-United States, 2013-2017. 62
35350171 2022
47
Retrospective Analysis of Ugandan Men with Urethritis Reveals Mycoplasma genitalium and Associated Macrolide Resistance. 62
35412392 2022
48
Clinical Importance of Superior Sensitivity of the Aptima TMA-Based Assays for Mycoplasma genitalium Detection. 62
35317613 2022
49
Periurethral Abscess in Corpus Spongiosum Diagnosed on Ultrasonography: A Rarest Case Report. 62
35832366 2022
50
Primary urothelial carcinoma of the male anterior urethra; A case report. 62
35495412 2022

Variations for Urethritis

Expression for Urethritis

Search GEO for disease gene expression data for Urethritis.

Pathways for Urethritis

Pathways related to Urethritis according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14 TNF TLR4 TLR2 IL6 IL1B IL10
2
Show member pathways
13.42 CD4 CXCL8 IL10 IL1B IL6 TLR2
3
Show member pathways
12.87 TNF TLR4 TLR2 IL6 IL1B CXCL8
4
Show member pathways
12.72 TNF TLR4 TLR2 IL6 IL1B
5
Show member pathways
12.65 CXCL8 IL1B IL6 TLR2 TNF
6
Show member pathways
12.61 TNF IL6 IL1B IL10 CD4
7
Show member pathways
12.6 CXCL8 IL1B IL6 TLR2 TLR4 TNF
8 12.59 TNF TLR2 IL1B IL10 CD8A
9
Show member pathways
12.37 TNF TLR4 TLR2 IL6 IL1B DEFB4A
10
Show member pathways
12.36 TNF TLR4 IL6 IL1B CXCL8
11
Show member pathways
12.36 TLR2 DEFB4A DEFA5 CD4 CAMP
12
Show member pathways
12.3 TNF TLR2 IL6 CXCL8
13 12.22 TNF TLR4 TLR2 IL6
14 12.2 TNF IL6 IL1B IL10 HSPD1 CXCL8
15
Show member pathways
12.17 TNF IL10 CD8A CD4
16 12.13 TNF IL6 IL1B IL10
17 12.1 TNF IL6 IL10 CD8A CD4
18 12.09 TNF TLR4 IL6 IL1B CXCL8
19 12.05 TNF IL6 IL1B IL10 CXCL8
20
Show member pathways
11.96 TLR4 TLR2 IL6 IL1B CD4
21 11.93 TNF IL1B IL10 CXCL8
22 11.88 CD4 CD8A IL10 IL1B TNF
23
Show member pathways
11.85 IL6 CXCL8 CRP CD8A CD4
24 11.83 TLR4 IL6 IL10 CD4
25 11.83 TNF TLR4 IL6 IL1B CXCL8
26 11.79 TNF TLR4 IL6 IL10 CRP
27 11.75 CXCL8 IL1B IL6 TNF
28
Show member pathways
11.74 CXCL8 IL1B IL6 TNF
29 11.73 IL6 IL1B CD4
30 11.72 IL6 IL10 CXCL8
31 11.69 TNF TLR4 IL6 IL10 CXCL8
32 11.67 TNF TLR4 IL6 IL1B IL10
33
Show member pathways
11.63 TNF TLR4 TLR2 IL6 IL10
34 11.62 TNF TLR4 CD4
35 11.58 TNF IL10 CXCL8
36 11.52 TNF IL6 IL1B
37 11.5 TNF TLR4 IL6
38 11.5 TNF IL6 IL1B IL10 CD8A CD4
39 11.48 TNF TLR4 TLR2 KLK3 IL1B
40 11.44 CXCL8 IL10 IL1B IL6 TNF
41 11.38 TNF IL6 IL1B CXCL8
42 11.35 TNF IL6 IL1B
43 11.34 TNF IL6 IL1B CXCL8
44 11.32 TNF IL6 IL10 CXCL8
45 11.26 TNF TLR4 IL6 IL1B IL10
46 11.17 TLR4 IL6 IL1B IL10
47
Show member pathways
11.17 TNF TLR4 TLR2 IL6 IL1B IL10
48 11.14 TNF TLR4 IL6 DEFB4A CXCL8 CAMP
49 11.12 TNF IL6 IL1B IL10 CD4
50 11.09 CRP CXCL8 IL6 TNF

GO Terms for Urethritis

Cellular components related to Urethritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.03 ALB CAMP CD8A CRP CXCL8 DEFA5
2 secretory granule GO:0030141 9.76 KLK3 IL1B HSPD1 DEFA5
3 extracellular space GO:0005615 9.7 TNF KLK3 IL6 IL1B IL10 HSPD1
4 lipopolysaccharide receptor complex GO:0046696 9.56 TLR4 HSPD1

Biological processes related to Urethritis according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.46 CRP CXCL8 IL1B IL6 TLR2 TLR4
2 negative regulation of cell population proliferation GO:0008285 10.42 CXCL8 IL10 IL1B IL6 TLR2 TNF
3 inflammatory response GO:0006954 10.41 TNF TLR4 TLR2 IL6 IL1B CXCL8
4 positive regulation of DNA-binding transcription factor activity GO:0051091 10.28 TNF IL6 IL1B IL10
5 positive regulation of inflammatory response GO:0050729 10.27 TNF TLR4 TLR2 IL1B
6 defense response to bacterium GO:0042742 10.26 TNF TLR4 IL10 DEFB4A DEFA5 CAMP
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.25 IL1B IL6 TLR2 TLR4 TNF
8 positive regulation of type II interferon production GO:0032729 10.24 TNF TLR4 IL1B HSPD1
9 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 10.23 DEFB4A DEFA5 CXCL8 CAMP
10 positive regulation of NIK/NF-kappaB signaling GO:1901224 10.21 TNF TLR4 TLR2 IL1B
11 positive regulation of interleukin-12 production GO:0032735 10.17 TLR4 TLR2 HSPD1
12 positive regulation of nitric oxide biosynthetic process GO:0045429 10.16 TNF TLR4 IL1B
13 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.16 TNF IL6 IL10
14 positive regulation of interleukin-6 production GO:0032755 10.15 TNF TLR4 TLR2 IL6 IL1B HSPD1
15 liver regeneration GO:0097421 10.14 TNF IL6 IL10
16 positive regulation of cytokine production involved in inflammatory response GO:1900017 10.14 TNF TLR4 IL6
17 response to lipopolysaccharide GO:0032496 10.14 TNF TLR4 TLR2 IL1B IL10
18 negative regulation of neurogenesis GO:0050768 10.13 TNF IL6 IL1B
19 MyD88-dependent toll-like receptor signaling pathway GO:0002755 10.11 TLR4 TLR2 HSPD1
20 positive regulation of macrophage activation GO:0043032 10.1 TLR4 IL10 HSPD1
21 defense response to Gram-negative bacterium GO:0050829 10.1 CAMP CD4 DEFA5 DEFB4A IL6 TLR4
22 positive regulation of glial cell proliferation GO:0060252 10.09 TNF IL6 IL1B
23 positive regulation of interleukin-10 production GO:0032733 10.08 HSPD1 IL6 TLR2 TLR4
24 positive regulation of heterotypic cell-cell adhesion GO:0034116 10.06 TNF IL1B IL10
25 lipopolysaccharide-mediated signaling pathway GO:0031663 10.06 TNF TLR4 TLR2 IL1B
26 positive regulation of chemokine production GO:0032722 10.06 IL1B IL6 TLR2 TLR4 TNF
27 immune response GO:0006955 10.06 CD4 CD8A CXCL8 DEFB4A IL10 IL1B
28 positive regulation of interleukin-8 production GO:0032757 10.03 TNF TLR4 TLR2 IL6 IL1B DEFA5
29 endothelial cell apoptotic process GO:0072577 10.02 TNF IL10 CD248
30 negative regulation of cytokine production involved in immune response GO:0002719 9.99 TNF IL10
31 positive regulation of fever generation GO:0031622 9.99 TNF IL1B
32 positive regulation of neuroinflammatory response GO:0150078 9.99 TNF IL6 IL1B
33 sequestering of triglyceride GO:0030730 9.97 TNF IL1B
34 negative regulation of lipid storage GO:0010888 9.97 TNF IL6 CRP
35 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.96 IL1B TNF
36 positive regulation of matrix metallopeptidase secretion GO:1904466 9.95 TLR4 TLR2
37 chronic inflammatory response to antigenic stimulus GO:0002439 9.95 IL10 TNF
38 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.94 TLR2 TLR4
39 response to molecule of bacterial origin GO:0002237 9.93 TLR2 IL10 CXCL8
40 defense response GO:0006952 9.92 CAMP CXCL8 DEFA5 DEFB4A TNF
41 vascular endothelial growth factor production GO:0010573 9.91 TNF IL6 IL1B
42 cellular response to lipopolysaccharide GO:0071222 9.83 TNF TLR4 IL6 IL1B IL10 DEFA5
43 response to external stimulus GO:0009605 9.75 CXCL8 TLR2 TLR4
44 defense response to Gram-positive bacterium GO:0050830 9.53 TNF TLR2 IL6 IL1B DEFB4A DEFA5

Molecular functions related to Urethritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.61 TNF IL6 IL1B IL10 CXCL8
2 lipopolysaccharide immune receptor activity GO:0001875 9.46 TLR4 TLR2
3 lipopolysaccharide binding GO:0001530 9.23 TLR4 TLR2 HSPD1 CAMP

Sources for Urethritis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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