MCID: URT001
MIFTS: 42

Urethritis

Categories: Nephrological diseases

Aliases & Classifications for Urethritis

MalaCards integrated aliases for Urethritis:

Name: Urethritis 12 45 15 17 74
Non-Gonococcal Urethritis 12 74
Nongonococcal Urethritis 12 56
Nonspecific Urethritis 74

Classifications:



External Ids:

Disease Ontology 12 DOID:1343
ICD9CM 36 597.80
MeSH 45 D014526
NCIt 51 C26904
SNOMED-CT 69 31822004

Summaries for Urethritis

MalaCards based summary : Urethritis, also known as non-gonococcal urethritis, is related to urethral syndrome and cervicitis. An important gene associated with Urethritis is DEFB4A (Defensin Beta 4A). The drugs Azithromycin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and skin, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 Urethritis is inflammation of the urethra. The most common symptom is painful or difficult urination. It... more...

Related Diseases for Urethritis

Diseases related to Urethritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 377)
# Related Disease Score Top Affiliating Genes
1 urethral syndrome 32.9 EXTL3 MRAP MT-TG MTRR PHB2
2 cervicitis 31.4 DEFB4A HSPD1 MRAP MT-TG YME1L1
3 balanitis 30.6 MRAP PHB2
4 bone inflammation disease 29.3 MRAP PHB2
5 urethral stricture 12.6
6 posterior urethral valves 12.6
7 urethral diverticulum 12.5
8 urethral cancer 12.4
9 urethral gland abscess 12.3
10 urethral benign neoplasm 12.2
11 urethral calculus 12.2
12 urethral obstruction sequence 12.2
13 female urethral cancer 12.2
14 cervical ribs, sprengel anomaly, anal atresia, and urethral obstruction 12.2
15 urethral villous adenoma 12.2
16 male urethral cancer 12.1
17 urethral false passage 12.1
18 urethral intrinsic sphincter deficiency 12.1
19 anterior urethral valve 12.1
20 duplication of urethra 12.0
21 urethral urothelial papilloma 12.0
22 urethral verrucous carcinoma 12.0
23 vitiligo, progressive, with mental retardation and urethral duplication 11.9
24 infective urethral stricture 11.9
25 prostatic urethral cancer 11.9
26 penile urethral cancer 11.9
27 bulbomembranous urethral cancer 11.9
28 posterior urethra cancer 11.8
29 hypospadias 11.7
30 anterior urethra cancer 11.7
31 urethra leiomyoma 11.6
32 exstrophy of bladder 11.6
33 atresia of urethra 11.5
34 urethra transitional cell carcinoma 11.5
35 urethra squamous cell carcinoma 11.5
36 reactive arthritis 11.3
37 urethra adenocarcinoma 11.3
38 hypospadias 1, x-linked 11.2
39 vacterl association, x-linked, with or without hydrocephalus 11.2
40 congenital anomalies of kidney and urinary tract 1 11.2
41 proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome 11.1
42 urethra cancer 11.1
43 congenital anomalies of kidney and urinary tract 2 11.0
44 mucoepithelial dysplasia, hereditary 11.0
45 testicular regression syndrome 11.0
46 hypospadias 2, x-linked 11.0
47 pigmentary disorder, reticulate, with systemic manifestations, x-linked 11.0
48 otopalatodigital syndrome, type ii 11.0
49 congenital anomalies of kidney and urinary tract 3 11.0
50 meningococcal infection 11.0

Comorbidity relations with Urethritis via Phenotypic Disease Network (PDN):


Acute Cystitis Bladder Neck Obstruction
Cystitis Prostate Cancer
Prostatic Hypertrophy Trigonitis
Urethral Stricture

Graphical network of the top 20 diseases related to Urethritis:



Diseases related to Urethritis

Symptoms & Phenotypes for Urethritis

GenomeRNAi Phenotypes related to Urethritis according to GeneCards Suite gene sharing:

27 (show all 19)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.64 HSPD1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.64 MTRR
3 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.64 PHB2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.64 HSPD1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.64 HSPD1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.64 MTRR
7 Increased shRNA abundance (Z-score > 2) GR00366-A-158 9.64 MTRR
8 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.64 HSPD1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.64 MTRR
10 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.64 PHB2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.64 PHB2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.64 PHB2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.64 PHB2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.64 MTRR
15 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.64 MTRR
16 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.64 HSPD1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.64 PHB2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-92 9.64 MTRR
19 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.64 HSPD1 MTRR PHB2

Drugs & Therapeutics for Urethritis

Drugs for Urethritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 447043 55185
2
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 564-25-0 54671203
3
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
4
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
5
Sulfamethoxazole Approved Phase 4,Not Applicable 723-46-6 5329
6
Trimethoprim Approved, Vet_approved Phase 4,Not Applicable 738-70-5 5578
7 Antimalarials Phase 4,Phase 3,Phase 2,Not Applicable
8 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable
9 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
10 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable
11 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 1
12 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
13 Anti-Infective Agents, Urinary Phase 4,Phase 2,Not Applicable
14 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
15 Iron-Dextran Complex Phase 4
16 Renal Agents Phase 4,Phase 2,Not Applicable
17
Aztreonam Approved Phase 2, Phase 3 78110-38-0 5742832 5362041
18
Ursodeoxycholic acid Approved, Investigational Phase 3 128-13-2 31401
19
chenodeoxycholic acid Approved Phase 3 474-25-9 10133
20 Gastrointestinal Agents Phase 3,Not Applicable
21 Cholagogues and Choleretics Phase 3
22 Liver Extracts Phase 3
23 Laxatives Phase 3
24 Cathartics Phase 3
25
Tinidazole Approved, Investigational Phase 2 19387-91-8 5479
26 Alkylating Agents Phase 2
27 Amdinocillin Pivoxil Phase 2
28
Ceftriaxone Approved Phase 1 73384-59-5 5479530 5361919
29
Cefixime Approved, Investigational Phase 1 79350-37-1 5362065 54362
30
Ciprofloxacin Approved, Investigational Phase 1 85721-33-1 2764
31 Cytochrome P-450 Enzyme Inhibitors Phase 1,Not Applicable
32 Vaccines Phase 1
33 Cytochrome P-450 CYP1A2 Inhibitors Phase 1
34 Topoisomerase Inhibitors Phase 1
35 Orange Approved Not Applicable
36
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
37
Prednisolone phosphate Approved, Vet_approved Not Applicable 302-25-0
38
leucovorin Approved Not Applicable 58-05-9 143 6006
39
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
40
Methylprednisolone hemisuccinate Approved Not Applicable 2921-57-5
41
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
42
Prednisolone hemisuccinate Experimental Not Applicable 2920-86-7
43 Tea Not Applicable
44
protease inhibitors Not Applicable
45 HIV Protease Inhibitors Not Applicable
46 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
47 Neuroprotective Agents Not Applicable
48 Hormones Not Applicable
49 Antiemetics Not Applicable
50 Peripheral Nervous System Agents Not Applicable

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
2 Cotrimoxazole Prophylaxis in Transurethral Resection or Greenlight Laser Vaporisation of the Prostate Recruiting NCT03633643 Phase 4 oral applications of TMP/SMX 800/160 mg (Nopil forte® tablets);oral applications of Placebo
3 Mycoplasma Genitalium Antibiotic Susceptibility and Treatment (MEGA) Completed NCT00358462 Phase 3 Azithromycin;Doxycycline
4 Aztreonam for Pharyngeal Gonorrhea Recruiting NCT03867734 Phase 2, Phase 3 Aztreonam
5 ENHANCE: Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and an Inadequate Response to or an Intolerance to Ursodeoxycholic Acid (UDCA) Recruiting NCT03602560 Phase 3 seladelpar 5-10 mg;seladelpar 10 mg;Placebo
6 Study Evaluating the Efficacy and Safety of Obeticholic Acid in Subjects With Compensated Cirrhosis Due to Nonalcoholic Steatohepatitis Recruiting NCT03439254 Phase 3 Obeticholic acid (10 mg);Obeticholic acid (10 mg to 25 mg);Placebo
7 NGU: Doxycycline (Plus or Minus Tinidazole) Versus Azithromycin (Plus or Minus Tinidazole) Completed NCT00322465 Phase 2 Tinidazole;Doxycycline;Azithromycin
8 Study to Improve Partner Services for STD Prevention Completed NCT00207467 Phase 2
9 A Web-based Intervention Study to Reduce High-risk Sexual Behavior by Persons Living With HIV AIDS (PLWH) Completed NCT01198418 Phase 1, Phase 2
10 Mecillinam for Treatment of Genital Chlamydia Infection Terminated NCT02083276 Phase 2 Pivmecillinamhydrochlorid
11 Trial to Assess the Efficacy of F598 in Preventing an Experimental Urethral Infection With N. Gonorrhoeae in Healthy Males Terminated NCT03222401 Phase 2 1 mg/kg single infusion of F598;3 mg/kg single infusion of F598;10 mg/kg single infusion of F598
12 Experimental Human Infection With Neisseria Gonorrhoeae Recruiting NCT03840811 Phase 1 Cefixime;Ceftriaxone;Ciprofloxacin
13 Accuracy of Detection Using ENdocuff Optimisation of Mucosal Abnormalities Unknown status NCT02552017 Not Applicable
14 Chronic Inflammatory Condition of the Male Genital Tract Completed NCT01732172 Not Applicable
15 Antimicrobial Susceptibility Patterns of N. Gonorrhea Isolates in an Era of Quinolone Resistance Completed NCT00692822
16 Chlamydia Trachomatis Immunology and Vaccinology Study Completed NCT01150747 ceftriaxone;Azithromycin
17 Effects of Transcutaneous Acupoint Electrical Stimulation on Intestinal Obstruction After Gastrointestinal Surgery Recruiting NCT03086304 Not Applicable
18 Therapeutic Evaluation of Steroids in IgA Nephropathy Global Study (TESTING Low Dose Study) Recruiting NCT01560052 Not Applicable methylprednisolone;Placebo
19 A Multicenter, Multinational, Observational Morquio A Registry Study (MARS) Recruiting NCT02294877 Vimizim® (elosulfase alfa)
20 Comparison of Standard of Care Guidelines for Mycoplasma Genitalium Infections Among Men With Non-gonococcal Urethritis Not yet recruiting NCT03910907 Comparison of two standard of care regimens
21 Combined Spinal Epidural Urinary Retention Terminated NCT01597791 Not Applicable

Search NIH Clinical Center for Urethritis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: urethritis

Genetic Tests for Urethritis

Anatomical Context for Urethritis

MalaCards organs/tissues related to Urethritis:

42
Testes, Kidney, Skin, Pancreas, Lymph Node, Cervix, T Cells

Publications for Urethritis

Articles related to Urethritis:

(show top 50) (show all 1568)
# Title Authors Year
1
Detection of ureaplasmas and bacterial vaginosis associated bacteria and their association with non-gonococcal urethritis in men. ( 30946763 )
2019
2
A microbial game of whack-a-mole: clinical case series of the urethral uncloaking phenomenon caused by Corynebacterium glucuronolyticum in men treated for Chlamydia trachomatis urethritis. ( 30168068 )
2019
3
Neonatal Conjunctivitis Caused by Neisseria meningitidis US Urethritis Clade, New York, USA, August 2017. ( 31002061 )
2019
4
Clinical, histopathologic, cystoscopic, and fluorescence in situ hybridization analysis of proliferative urethritis in 22 dogs. ( 30516855 )
2019
5
Orogenital Transmission of Neisseria meningitidis Causing Acute Urethritis in Men Who Have Sex with Men. ( 30561300 )
2019
6
Classification of non-gonococcal urethritis: a review. ( 30953260 )
2019
7
Is it time for the US and Canada to reconsider macrolides as the first line empiric treatment for males with symptomatic urethritis? ( 30972414 )
2019
8
Mycoplasma genitalium in symptomatic male urethritis: macrolide use is associated with increased resistance. ( 30972419 )
2019
9
Delay in Seeking Health Care Services After Onset of Urethritis Symptoms in Men. ( 30985634 )
2019
10
Men who have sex with men with Mycoplasma genitalium-positive nongonococcal urethritis are more likely to have macrolide resistant strains than men with only female partners: a prospective study. ( 31008841 )
2019
11
Is the Current Classification of Urethritis as Gonococcal or Nongonoccal Becoming Obsolete? ( 30503160 )
2019
12
Haemophilus Species Isolated in Urethral Exudates as a Possible Causative Agent in Acute Urethritis: A Study of 38 Cases. ( 30390917 )
2019
13
Heteroresistance to the model antimicrobial peptide polymyxin B in the emerging Neisseria meningitidis lineage 11.2 urethritis clade: mutations in the pilMNOPQ operon. ( 30338585 )
2019
14
Management of Urethritis: Is It Still the Time for Empirical Antibiotic Treatments? ( 30318465 )
2019
15
Cross-sectional study of urethral exposures at last sexual episode associated with non-gonococcal urethritis among STD clinic patients. ( 30181326 )
2019
16
Delay in Seeking Healthcare Services Following Onset of Urethritis Symptoms in Men. ( 30633061 )
2019
17
Candida glabrata: A Unique Cause of Necrotizing Urethritis. ( 29971173 )
2018
18
Chlamydia trachomatis asymptomatic urethritis recurrence among males living with HIV-1. ( 30379232 )
2018
19
Prevalence of asymptomatic urethritis by Chlamydia trachomatis and Neisseria gonorrhoeae and associated risk factors among males living with HIV-1. ( 29538508 )
2018
20
Haemophilus parainfluenzae urethritis through orogenital transmission. ( 30623185 )
2018
21
Long duration of asymptomatic Mycoplasma genitalium infection after syndromic treatment for nongonococcal urethritis. ( 30281079 )
2018
22
Microscopy of Gram-stained urethral smear in the diagnosis of urethritis: Which threshold value should be selected? ( 30238498 )
2018
23
Antibiotic resistance in Neisseria gonorrhoea and treatment outcomes of gonococcal urethritis suspected patients in two large hospitals in Bhutan, 2015. ( 30067836 )
2018
24
The bacterial microbiota in first-void urine from men with and without idiopathic urethritis. ( 30052651 )
2018
25
Neisseria meningitidis urethritis: synthesis of published data. ( 29797510 )
2018
26
Prevalence of Mycoplasma genitalium in men with urethritis in a large public hospital in Brussels, Belgium: An observational, cross-sectional study. ( 29698421 )
2018
27
Isotretinoin-induced urethritis versus non-gonococcal urethritis in a man who has sex with men: an open debate. ( 29512421 )
2018
28
Expansion of a urethritis-associated Neisseria meningitidis clade in the United States with concurrent acquisition of N. gonorrhoeae alleles. ( 29499642 )
2018
29
Defining the Urethritis Syndrome in Men Using Patient Reported Symptoms. ( 29465655 )
2018
30
Evaluation of the Microbiological Efficacy of a Single 2-Gram Dose of Extended-Release Azithromycin by Population Pharmacokinetics and Simulation in Japanese Patients with Gonococcal Urethritis. ( 29038284 )
2018
31
'Haemophilus quentini' in the urethra of men complaining of urethritis symptoms. ( 28889986 )
2018
32
Prevalence of Mycoplasma genitalium and other sexually transmitted infections causing urethritis among high-risk heterosexual male patients in Estonia. ( 28868962 )
2018
33
Cost-effectiveness of microscopy of urethral smears for asymptomatic Mycoplasma genitalium urethritis in men in England. ( 28669322 )
2018
34
GyrA and/or ParC alterations of Haemophilus influenzae strains isolated from the urethra of men with acute urethritis. ( 29138021 )
2018
35
Should Female Partners of Men With Non-Gonococcal Urethritis, Negative for Chlamydia trachomatis and Mycoplasma genitalium, Be Informed and Treated? Clinical Outcomes From a Partner Study of Heterosexual Men With NGU. ( 28079749 )
2017
36
Haemophilus influenzae Isolated From Men With Acute Urethritis: Its Pathogenic Roles, Responses to Antimicrobial Chemotherapies, and Antimicrobial Susceptibilities. ( 28282645 )
2017
37
Antimicrobial susceptibility of Haemophilus influenzae strains isolated from the urethra of men with acute urethritis and/or epididymitis. ( 28619239 )
2017
38
Clinical courses of herpes simplex virus-induced urethritis in men. ( 28412134 )
2017
39
A clinico-etiological study of urethritis in men attending sexually transmitted disease clinic at a tertiary hospital. ( 30148266 )
2017
40
Case Report of Urethritis in a Male Patient Infected with Two Different Isolates of Multiple Drug-Resistant Neisseria gonorrhoeae. ( 29167794 )
2017
41
Proposed treatment strategies for non-gonococcal urethritis. ( 29115261 )
2017
42
Re: Etiology of Symptomatic Urethritis in Men and Association with Sexual Behaviors. ( 29059739 )
2017
43
Preliminary Experience with Instillation of Triamcinolone Acetonide into the Urethra for Idiopathic Urethritis: A Prospective Pilot Study. ( 29023188 )
2017
44
Genomic Characterization of Urethritis-Associated Neisseria meningitidis Shows that a Wide Range of N. meningitidis Strains Can Cause Urethritis. ( 28904187 )
2017
45
The detection of microorganisms related to urethritis from the oral cavity of male patients with urethritis. ( 28803864 )
2017
46
Large Cluster of Neisseria meningitidis Urethritis in Columbus, Ohio, 2015. ( 28481980 )
2017
47
Treatment outcomes and loss to follow-up rate of male patients with gonococcal and nongonococcal urethritis who attended the sexually transmitted disease clinic: An 8-year retrospective study. ( 28442801 )
2017
48
Macrolide and quinolone-resistant Mycoplasma genitalium in a man with persistent urethritis: the tip of the British iceberg? ( 28438948 )
2017
49
The Diagnosis of Nongonococcal Urethritis in Men: Can There Be a Universal Standard? ( 28178119 )
2017
50
Microscopy of Stained Urethral Smear in Male Urethritis; Which Cutoff Should be Used? ( 28178118 )
2017

Variations for Urethritis

Expression for Urethritis

Search GEO for disease gene expression data for Urethritis.

Pathways for Urethritis

GO Terms for Urethritis

Cellular components related to Urethritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial inner membrane GO:0005743 8.8 HSPD1 PHB2 YME1L1

Biological processes related to Urethritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.26 HSPD1 MNAT1 PHB2 YME1L1
2 mitochondrion organization GO:0007005 8.8 HSPD1 PHB2 YME1L1

Sources for Urethritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....