MCID: URT001
MIFTS: 43

Urethritis

Categories: Nephrological diseases

Aliases & Classifications for Urethritis

MalaCards integrated aliases for Urethritis:

Name: Urethritis 12 44 15 73
Non-Gonococcal Urethritis 12 73
Nongonococcal Urethritis 12 55
Nonspecific Urethritis 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1343
ICD10 33 N34.2 N37.0
ICD9CM 35 597.80
MeSH 44 D014526
NCIt 50 C26904
SNOMED-CT 68 31822004

Summaries for Urethritis

MalaCards based summary : Urethritis, also known as non-gonococcal urethritis, is related to urethral syndrome and cervicitis. An important gene associated with Urethritis is DEFB4A (Defensin Beta 4A), and among its related pathways/superpathways are Tuberculosis and Bacterial infections in CF airways. The drugs Doxycycline and Lymecycline have been mentioned in the context of this disorder. Affiliated tissues include testes, prostate and kidney.

Wikipedia : 76 Urethritis is inflammation of the urethra. The most common symptom is painful or difficult urination. It... more...

Related Diseases for Urethritis

Diseases related to Urethritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 342)
# Related Disease Score Top Affiliating Genes
1 urethral syndrome 33.5 EXTL3 MRAP MT-TG PHB2 TLR6
2 cervicitis 31.6 DEFB4A HSPD1 MRAP MT-TG YME1L1
3 balanitis 30.5 MRAP PHB2
4 pelvic inflammatory disease 29.7 HSPD1 TLR1 TLR6
5 urethral stricture 12.6
6 posterior urethral valves 12.5
7 urethral diverticulum 12.5
8 urethral cancer 12.4
9 urethral gland abscess 12.2
10 urethral benign neoplasm 12.2
11 urethral calculus 12.2
12 urethral obstruction sequence 12.2
13 female urethral cancer 12.1
14 cervical ribs, sprengel anomaly, anal atresia, and urethral obstruction 12.1
15 male urethral cancer 12.1
16 urethral false passage 12.1
17 urethral intrinsic sphincter deficiency 12.1
18 urethral villous adenoma 12.1
19 anterior urethral valve 12.1
20 duplication of urethra 12.0
21 urethral urothelial papilloma 12.0
22 urethral verrucous carcinoma 12.0
23 vitiligo, progressive, with mental retardation and urethral duplication 11.9
24 infective urethral stricture 11.9
25 prostatic urethral cancer 11.9
26 penile urethral cancer 11.9
27 bulbomembranous urethral cancer 11.9
28 posterior urethra cancer 11.8
29 hypospadias 11.6
30 anterior urethra cancer 11.6
31 exstrophy of bladder 11.5
32 atresia of urethra 11.4
33 urethra transitional cell carcinoma 11.4
34 urethra squamous cell carcinoma 11.4
35 reactive arthritis 11.3
36 hypospadias 1, x-linked 11.2
37 vacterl association, x-linked, with or without hydrocephalus 11.1
38 congenital anomalies of kidney and urinary tract 1 11.1
39 proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome 11.1
40 congenital anomalies of kidney and urinary tract 2 11.0
41 mucoepithelial dysplasia, hereditary 11.0
42 testicular regression syndrome 11.0
43 hypospadias 2, x-linked 11.0
44 pigmentary disorder, reticulate, with systemic manifestations, x-linked 11.0
45 otopalatodigital syndrome, type ii 11.0
46 transverse myelitis 11.0
47 urethra leiomyoma 10.9
48 urethra adenocarcinoma 10.9
49 urethra clear cell adenocarcinoma 10.9
50 urethra inverted papilloma 10.9

Comorbidity relations with Urethritis via Phenotypic Disease Network (PDN):


Acute Cystitis Bladder Neck Obstruction
Cystitis Prostate Cancer
Prostatic Hypertrophy Trigonitis
Urethral Stricture

Graphical network of the top 20 diseases related to Urethritis:



Diseases related to Urethritis

Symptoms & Phenotypes for Urethritis

Drugs & Therapeutics for Urethritis

Drugs for Urethritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 564-25-0 54671203
2
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
3
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
4
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 55185 447043
5
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
6
Sulfamethoxazole Approved Phase 4 723-46-6 5329
7 Antimalarials Phase 4,Phase 3,Phase 2
8 Antibiotics, Antitubercular Phase 4,Phase 3
9 Antiparasitic Agents Phase 4,Phase 3,Phase 2
10 Antiprotozoal Agents Phase 4,Phase 3,Phase 2
11 Anti-Infective Agents Phase 4,Phase 3,Phase 2
12 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
13 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
14 Renal Agents Phase 4,Phase 2
15 Iron-Dextran Complex Phase 4
16 Anti-Infective Agents, Urinary Phase 4,Phase 2
17
Tinidazole Approved, Investigational Phase 2 19387-91-8 5479
18 Alkylating Agents Phase 2
19 Amdinocillin Pivoxil Phase 2
20
Ceftriaxone Approved 73384-59-5 5479530 5361919
21 Tea Not Applicable

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
2 Cotrimoxazole Prophylaxis in Transurethral Resection or Greenlight Laser Vaporisation of the Prostate Recruiting NCT03633643 Phase 4 oral applications of TMP/SMX 800/160 mg (Nopil forte® tablets);oral applications of Placebo
3 Mycoplasma Genitalium Antibiotic Susceptibility and Treatment (MEGA) Completed NCT00358462 Phase 3 Azithromycin;Doxycycline
4 NGU: Doxycycline (Plus or Minus Tinidazole) Versus Azithromycin (Plus or Minus Tinidazole) Completed NCT00322465 Phase 2 Tinidazole;Doxycycline;Azithromycin
5 Study to Improve Partner Services for STD Prevention Completed NCT00207467 Phase 2
6 A Web-based Intervention Study to Reduce High-risk Sexual Behavior by Persons Living With HIV AIDS (PLWH) Completed NCT01198418 Phase 1, Phase 2
7 Mecillinam for Treatment of Genital Chlamydia Infection Terminated NCT02083276 Phase 2 Pivmecillinamhydrochlorid
8 Trial to Assess the Efficacy of F598 in Preventing an Experimental Urethral Infection With N. Gonorrhoeae in Healthy Males Terminated NCT03222401 Phase 2 1 mg/kg single infusion of F598;3 mg/kg single infusion of F598;10 mg/kg single infusion of F598
9 Chronic Inflammatory Condition of the Male Genital Tract Completed NCT01732172 Not Applicable
10 Antimicrobial Susceptibility Patterns of N. Gonorrhea Isolates in an Era of Quinolone Resistance Completed NCT00692822
11 Chlamydia Trachomatis Immunology and Vaccinology Study Completed NCT01150747 ceftriaxone;Azithromycin
12 Effects of Transcutaneous Acupoint Electrical Stimulation on Intestinal Obstruction After Gastrointestinal Surgery Recruiting NCT03086304 Not Applicable
13 Combined Spinal Epidural Urinary Retention Terminated NCT01597791 Not Applicable

Search NIH Clinical Center for Urethritis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: urethritis

Genetic Tests for Urethritis

Anatomical Context for Urethritis

MalaCards organs/tissues related to Urethritis:

41
Testes, Prostate, Kidney, T Cells, Brain, Bone, Spinal Cord

Publications for Urethritis

Articles related to Urethritis:

(show top 50) (show all 1140)
# Title Authors Year
1
Evaluation of the Microbiological Efficacy of a Single 2-Gram Dose of Extended-Release Azithromycin by Population Pharmacokinetics and Simulation in Japanese Patients with Gonococcal Urethritis. ( 29038284 )
2018
2
Defining the Urethritis Syndrome in Men Using Patient Reported Symptoms. ( 29465655 )
2018
3
<i>Candida glabrata</i>: A Unique Cause of Necrotizing Urethritis. ( 29971173 )
2018
4
Isotretinoin-induced urethritis versus non-gonococcal urethritis in a man who has sex with men: an open debate. ( 29512421 )
2018
5
Expansion of a urethritis-associated Neisseria meningitidis clade in the United States with concurrent acquisition of N. gonorrhoeae alleles. ( 29499642 )
2018
6
GyrA and/or ParC alterations of Haemophilus influenzae strains isolated from the urethra of men with acute urethritis. ( 29138021 )
2018
7
Neisseria meningitidis urethritis: synthesis of published data. ( 29797510 )
2018
8
Prevalence of Mycoplasma genitalium in men with urethritis in a large public hospital in Brussels, Belgium: An observational, cross-sectional study. ( 29698421 )
2018
9
Prevalence of asymptomatic urethritis by Chlamydia trachomatis and Neisseria gonorrhoeae and associated risk factors among males living with HIV-1. ( 29538508 )
2018
10
Chlamydia trachomatis asymptomatic urethritis recurrence among males living with HIV-1. ( 30379232 )
2018
11
A microbial game of whack-a-mole: clinical case series of the urethral uncloaking phenomenon caused by Corynebacterium glucuronolyticum in men treated for Chlamydia trachomatis urethritis. ( 30168068 )
2018
12
The bacterial microbiota in first-void urine from men with and without idiopathic urethritis. ( 30052651 )
2018
13
Antibiotic resistance in Neisseria gonorrhoea and treatment outcomes of gonococcal urethritis suspected patients in two large hospitals in Bhutan, 2015. ( 30067836 )
2018
14
Cross-sectional study of urethral exposures at last sexual episode associated with non-gonococcal urethritis among STD clinic patients. ( 30181326 )
2018
15
Microscopy of Gram-stained urethral smear in the diagnosis of urethritis: Which threshold value should be selected? ( 30238498 )
2018
16
Long duration of asymptomatic Mycoplasma genitalium infection after syndromic treatment for nongonococcal urethritis. ( 30281079 )
2018
17
Management of Urethritis: Is It Still the Time for Empirical Antibiotic Treatments? ( 30318465 )
2018
18
Heteroresistance to the model antimicrobial peptide polymyxin B in the emerging Neisseria meningitidis lineage 11.2 urethritis clade: mutations in the pilMNOPQ operon. ( 30338585 )
2018
19
Haemophilus Species Isolated in Urethral Exudates as a Possible Causative Agent in Acute Urethritis: A Study of 38 Cases. ( 30390917 )
2018
20
Is the Current Classification of Urethritis as Gonococcal or Nongonoccal Becoming Obsolete? ( 30503160 )
2018
21
Clinical, histopathologic, cystoscopic, and fluorescence in situ hybridization analysis of proliferative urethritis in 22 dogs. ( 30516855 )
2018
22
Neisseria gonorrhoeae DNA bacterial load in men with symptomatic and asymptomatic gonococcal urethritis. ( 28148678 )
2017
23
Quantitative Real-Time Polymerase Chain Reaction for the Diagnosis of Mycoplasma genitalium Infection in South African Men With and Without Symptoms of Urethritis. ( 27898565 )
2017
24
Large Cluster of Neisseria Meningitidis Urethritis in Columbus, Ohio, 2015. ( 28481980 )
2017
25
Microscopy of Stained Urethral Smear in Male Urethritis; Which Cutoff Should be Used? ( 28178118 )
2017
26
Re: Etiology of Symptomatic Urethritis in Men and Association with Sexual Behaviors. ( 29059739 )
2017
27
Treatment outcomes and loss to follow-up rate of male patients with gonococcal and nongonococcal urethritis who attended the sexually transmitted disease clinic: An 8-year retrospective study. ( 28442801 )
2017
28
Neisseria meningitidis ST11 Complex Isolates Associated with Nongonococcal Urethritis, Indiana, USA, 2015-2016. ( 28098538 )
2017
29
Successful outcome of macrolide-resistant Mycoplasma genitalium urethritis after spectinomycin treatment: a case report. ( 27707988 )
2017
30
Genomic characterization of urethritis-associated Neisseria meningitidis shows that a wide range of N. meningitidis strains can cause urethritis. ( 28904187 )
2017
31
Clinical Characteristics of Herpes Simplex Virus Urethritis Compared With Chlamydial Urethritis Among Men. ( 28079748 )
2017
32
Antimicrobial susceptibility of Haemophilus influenzae strains isolated from the urethra of men with acute urethritis and/or epididymitis. ( 28619239 )
2017
33
The detection of microorganisms related to urethritis from the oral cavity of male patients with urethritis. ( 28803864 )
2017
34
'Haemophilus quentini' in the urethra of men complaining of urethritis symptoms. ( 28889986 )
2017
35
Should Female Partners of Men With Non-Gonococcal Urethritis, Negative for Chlamydia trachomatis and Mycoplasma genitalium, Be Informed and Treated? Clinical Outcomes From a Partner Study of Heterosexual Men With NGU. ( 28079749 )
2017
36
Cost-effectiveness of microscopy of urethral smears for asymptomatic Mycoplasma genitalium urethritis in men in England. ( 28669322 )
2017
37
Clinical courses of herpes simplex virus-induced urethritis in men. ( 28412134 )
2017
38
Proposed treatment strategies for non-gonococcal urethritis. ( 29115261 )
2017
39
Prevalence of Mycoplasma genitalium and other sexually transmitted infections causing urethritis among high-risk heterosexual male patients in Estonia. ( 28868962 )
2017
40
Case Report of Urethritis in a Male Patient Infected with Two Different Isolates of Multiple Drug-Resistant<i>Neisseria gonorrhoeae</i>. ( 29167794 )
2017
41
Preliminary Experience with Instillation of Triamcinolone Acetonide into the Urethra for Idiopathic Urethritis: A Prospective Pilot Study. ( 29023188 )
2017
42
Haemophilus influenzae Isolated From Men With Acute Urethritis: Its Pathogenic Roles, Responses to Antimicrobial Chemotherapies, and Antimicrobial Susceptibilities. ( 28282645 )
2017
43
The Diagnosis of Nongonococcal Urethritis in Men: Can There Be a Universal Standard? ( 28178119 )
2017
44
Management of Herpetic Urethritis and Female Partners of Men With Nongonococcal Urethritis. ( 28079750 )
2017
45
Macrolide and quinolone-resistant Mycoplasma genitalium in a man with persistent urethritis: the tip of the British iceberg? ( 28438948 )
2017
46
A clinico-etiological study of urethritis in men attending sexually transmitted disease clinic at a tertiary hospital. ( 30148266 )
2017
47
Chlamydia trachomatis serovar G infection in a bisexual male with urethritis. ( 27126261 )
2016
48
Which empiric syndromic treatment for urethritis? ( 27794143 )
2016
49
Azithromycin Treatment Failure for Chlamydia trachomatis Among Heterosexual Men With Nongonococcal Urethritis. ( 27631353 )
2016
50
The first report: An analysis of bacterial flora of the first voided urine specimens of patients with male urethritis using the 16S ribosomal RNA gene-based clone library method. ( 27013259 )
2016

Variations for Urethritis

Expression for Urethritis

Search GEO for disease gene expression data for Urethritis.

Pathways for Urethritis

GO Terms for Urethritis

Cellular components related to Urethritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phagocytic vesicle membrane GO:0030670 8.96 TLR1 TLR6
2 membrane raft GO:0045121 8.8 HSPD1 TLR1 TLR6

Biological processes related to Urethritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 toll-like receptor signaling pathway GO:0002224 9.4 TLR1 TLR6
2 positive regulation of macrophage activation GO:0043032 9.37 HSPD1 TLR6
3 mitochondrion organization GO:0007005 9.33 HSPD1 PHB2 YME1L1
4 regulation of cytokine secretion GO:0050707 9.32 TLR1 TLR6
5 cell activation GO:0001775 9.26 TLR1 TLR6
6 positive regulation of interleukin-6 biosynthetic process GO:0045410 8.96 TLR1 TLR6
7 MyD88-dependent toll-like receptor signaling pathway GO:0002755 8.8 HSPD1 TLR1 TLR6

Molecular functions related to Urethritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 8.96 TLR1 TLR6
2 Toll-like receptor 2 binding GO:0035663 8.62 TLR1 TLR6

Sources for Urethritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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