MCID: URT001
MIFTS: 48

Urethritis

Categories: Nephrological diseases

Aliases & Classifications for Urethritis

MalaCards integrated aliases for Urethritis:

Name: Urethritis 12 43 15 17 71
Non-Gonococcal Urethritis 12 71
Nongonococcal Urethritis 12 54
Nonspecific Urethritis 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:1343
ICD9CM 34 597.80
MeSH 43 D014526
NCIt 49 C26904
SNOMED-CT 67 31822004
UMLS 71 C0041976 C0311389 C1112709

Summaries for Urethritis

MalaCards based summary : Urethritis, also known as non-gonococcal urethritis, is related to urethral syndrome and transverse myelitis. An important gene associated with Urethritis is DEFB4A (Defensin Beta 4A), and among its related pathways/superpathways are Human cytomegalovirus infection and Allograft rejection. The drugs Doxycycline and Lymecycline have been mentioned in the context of this disorder. Affiliated tissues include prostate, testes and kidney.

Wikipedia : 74 Urethritis is inflammation of the urethra. The most common symptom is painful or difficult urination. It... more...

Related Diseases for Urethritis

Diseases related to Urethritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1157)
# Related Disease Score Top Affiliating Genes
1 urethral syndrome 33.5 MTRR MT-TG MRAP KLK3 IL6 GPR182
2 transverse myelitis 32.3 TNF IL6 CXCL8
3 spinal cord injury 31.2 TNF IL6 CXCL8
4 syphilis 30.9 MRAP CRP CD40LG CD4
5 conjunctivitis 30.8 TNF IL6 CXCL8
6 prostatitis 30.8 TNF KLK3 IL6 CXCL8
7 reactive arthritis 30.7 TNF TLR4 TLR2 IL6 HSPD1 CXCL8
8 chancroid 30.6 HSPD1 CD40LG CD4
9 haemophilus influenzae 30.6 TNF TLR2 CXCL8
10 primary syphilis 30.4 CD40LG CD4
11 pyuria 30.3 KLK3 IL6 CXCL8 CRP CD40LG
12 latent syphilis 30.3 CD40LG CD4
13 intussusception 30.3 IL6 CRP CD40LG
14 ornithosis 30.3 NAT9 ESCO2 CD40LG
15 trichomoniasis 30.3 TNF IL6 CXCL8 CD40LG CD4
16 proctitis 30.2 TNF KLK3 CRP
17 cystitis 30.2 TNF TLR4 IL6 CXCL8 CRP
18 endocervicitis 30.2 MT-TG ESCO2
19 microsporidiosis 30.2 DEFB4A DEFA5 CD4
20 acute pyelonephritis 30.2 IL6 CXCL8 CRP
21 trachoma 30.2 TNF IL6 HSPD1
22 necrotizing fasciitis 30.1 IL6 CXCL8 CRP
23 inclusion conjunctivitis 30.1 NAT9 HSPD1 ESCO2 CD40LG
24 acute gonococcal cervicitis 30.1 VDAC1 MT-TG
25 amyloidosis 30.1 TNF IL6 CRP CD40LG
26 vaginal discharge 30.1 IL6 CXCL8 CRP CD40LG CD4
27 cervicitis 30.1 TLR4 TLR2 NAT9 MT-TG MRAP IL6
28 fasciitis 30.1 TNF IL6 CXCL8
29 anogenital venereal wart 30.0 TLR4 TLR2 CD4
30 diverticulitis 30.0 TNF IL6 CRP
31 orchitis 30.0 TNF IL6 CRP CD40LG CD4
32 cardiomyopathy, familial hypertrophic, 20 30.0 IL6 CXCL8 CD4
33 pleural empyema 30.0 CRP CD40LG CD4
34 ophthalmia neonatorum 29.9 NAT9 MTRR MAP10 GPR182
35 combined t cell and b cell immunodeficiency 29.9 IL6 CD40LG CD4
36 acute transverse myelitis 29.9 IL6 CXCL8
37 varicose veins 29.9 TNF IL6 CXCL8
38 chlamydia 29.9 TNF TLR4 TLR2 IL6 HSPD1 CXCL8
39 autoimmune pancreatitis 29.9 TNF CD40LG CD4
40 suppression of tumorigenicity 12 29.8 KLK3 IL6 CXCL8 CD4
41 decubitus ulcer 29.8 TNF IL6 CRP
42 optic papillitis 29.8 MRAP CRP CD40LG CD4
43 pyelonephritis 29.8 TNF TLR4 IL6 CXCL8 CRP
44 myelitis 29.8 TNF IL6 CXCL8 CD40LG
45 bacteriuria 29.7 TLR4 TLR2 IL6 CXCL8 CRP CD40LG
46 pulmonary edema 29.7 TNF CXCL8 CRP
47 lichen planus 29.7 TNF IL6 DEFB4A CXCL8
48 spinal cord disease 29.7 TNF IL6 CD40LG CD4
49 neurofibromatosis, type ii 29.7 TNF TLR2 IL6 DEFB4A CXCL8
50 irritant dermatitis 29.6 TNF IL6 CXCL8

Comorbidity relations with Urethritis via Phenotypic Disease Network (PDN):


Acute Cystitis Bladder Neck Obstruction
Cystitis Prostate Cancer
Prostatic Hypertrophy Trigonitis
Urethral Stricture

Graphical network of the top 20 diseases related to Urethritis:



Diseases related to Urethritis

Symptoms & Phenotypes for Urethritis

Drugs & Therapeutics for Urethritis

Drugs for Urethritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
2
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
3
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
4 Antiparasitic Agents Phase 4
5 Antiprotozoal Agents Phase 4
6 Antimalarials Phase 4
7 Antibiotics, Antitubercular Phase 4
8
Aztreonam Approved Phase 2, Phase 3 78110-38-0 5362041 5742832
9 Anti-Infective Agents Phase 2, Phase 3
10 Anti-Bacterial Agents Phase 2, Phase 3
11
Tinidazole Approved, Investigational Phase 2 19387-91-8 5479
12 Alkylating Agents Phase 2
13 Renal Agents Phase 2
14 Anti-Infective Agents, Urinary Phase 2
15 Amdinocillin Pivoxil Phase 2
16
Azithromycin Approved 83905-01-5 55185 447043
17
Cefixime Approved, Investigational 79350-37-1 54362 5362065
18 Anesthetics
19 Central Nervous System Depressants

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Study of Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Antibiotic Treatment Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
2 Mycoplasma Genitalium Antibiotic Susceptibility and Treatment: A Randomized Double-blind Trial of the Efficacy of Azithromycin and Doxycycline for Clinical and Microbiological Cure of M. Genitalium in Men With Nongonococcal Urethritis Completed NCT00358462 Phase 3 Azithromycin;Doxycycline
3 Aztreonam for Pharyngeal Gonorrhea: A Demonstration Study Completed NCT03867734 Phase 2, Phase 3 Aztreonam
4 Phase II Randomized, Placebo-Controlled Double-Blind 4-Arm Trial for the Treatment of Non-Gonococcal Urethritis (NGU): Doxycycline (Plus or Minus Tinidazole) Versus Azithromycin (Plus or Minus Tinidazole) Completed NCT00322465 Phase 2 Tinidazole;Doxycycline;Azithromycin
5 Prospective Study for Cost-Effectiveness Strategies to Improve Partner Notification: Female Trichomonas and Male Urethritis Studies Completed NCT00207467 Phase 2
6 Mecillinam for Treatment of Genital Chlamydia Infection in Asymptomatic Men Terminated NCT02083276 Phase 2 Pivmecillinamhydrochlorid
7 Study of the Prevalence of a Chronic Inflammatory Condition of the Male Genital Tract at a Distance and Urethritis Following. Completed NCT01732172
8 UROGEN WEL-DONE: Can the Novel Rapid Diagnostic UROGEN WELL D-ONE Detect Common Causes of Urinary Tract Infections and Urethritis? Completed NCT04182230
9 Antimicrobial Susceptibility Patterns of Neisseria Gonorrhea Isolates in an Era of Quinolone Resistance Completed NCT00692822
10 Expedited Partner Therapy as STI Control Among MSM in Peru Completed NCT01720654
11 Does Thoracic Epidural Analgesia Influence Urinary Micturition by Patients Undergoing Thoracic Surgery? An Observational, Prospective Study Completed NCT00976313
12 Effects of Thoracic Epidural Anesthesia on Lower Urinary Tract Function Completed NCT00790231
13 Comparison of Current Standard of Care Versus the Australian Guidelines for Management of Mycoplasma Genitalium Infections Among Men Being Treated for Non-gonococcal Urethritis Recruiting NCT03910907 Comparison of two standard of care regimens
14 Clinical Description of Spondylarthritis and Validation of Assessment of SpondyloArthritis International Society (ASAS) Criteria in West Indian Patients Seen in the Routine Consultation of Rheumatology. Recruiting NCT03564743
15 HD5 Levels in Catheter Versus Bag Urine Specimens in Young Children for the Diagnosis of UTI Recruiting NCT03163394
16 Do Women Receiving Low Dose Combined Spinal Epidural for Labor Analgesia Exhibit Less Bacteriuria Using a Urinary Retention Protocol Versus Routine Urinary Catheter Placement? Terminated NCT01597791

Search NIH Clinical Center for Urethritis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


ERYTHROMYCIN PWDR

Cochrane evidence based reviews: urethritis

Genetic Tests for Urethritis

Anatomical Context for Urethritis

MalaCards organs/tissues related to Urethritis:

40
Prostate, Testes, Kidney, Skin, Heart, Lung, Bone

Publications for Urethritis

Articles related to Urethritis:

(show top 50) (show all 4511)
# Title Authors PMID Year
1
Antibodies to Chlamydia trachomatis heat-shock protein 60 kDa and detection of Mycoplasma genitalium and ureaplasma urealyticum are associated independently with chronic nongonococcal urethritis. 54 61
12567170 2003
2
Isotretinoin induced urethritis: A case report & review of the literature. 61
31908966 2020
3
Antimicrobial resistance in sexually transmitted infections. 61
31840758 2020
4
A Rare Cause of a Scrotal Abscess due to the Symbiotic Infection of Gardnerella vaginalis and Prevotella bivia in an Adult Male. 61
32024139 2020
5
Comparative results of the implementation in daily practice of an evaluation checklist for patients with axial spondyloarthritis and psoriatic arthritis. 61
32037148 2020
6
Repeat Episodes of Symptomatic Urethritis Due to a Uropathogenic Meningococcal Clade. 61
31651709 2020
7
First isolation of human adenovirus type 85 by molecular analysis of adenoviruses in cases of urethritis. 61
31971505 2020
8
Evaluation of the ResistancePlus® MG FleXible cartridge for near point-of-care testing of Mycoplasma genitalium and associated macrolide resistance mutations. 61
31896664 2020
9
[Evaluation of the composition of the microbiota of the urethra in men with sexually transmitted infections]. 61
32003164 2020
10
Mycoplasma genitalium: A Review. 61
31329090 2020
11
A profile of the cobas® TV/ MG test for the detection of Trichomonas vaginalis and Mycoplasma genitalium. 61
31917618 2020
12
Recreational drugs and STI diagnoses among patients attending an STI/HIV reference clinic in Rome, Italy. 61
31101722 2019
13
Lack of Association Between the S83I ParC Mutation in Mycoplasma genitalium and Treatment Outcomes Among Men Who Have Sex With Men with Nongonococcal Urethritis. 61
31259853 2019
14
Emergence of multidrug resistance among Haemophilus parainfluenzae from respiratory and urogenital samples in Barcelona, Spain. 61
31828685 2019
15
MgpB Types among Mycoplasma genitalium Strains from Men Who Have Sex with Men in Berlin, Germany, 2016-2018. 61
31861901 2019
16
Men at risk of gonococcal urethritis: a case-control study in a Darwin sexual health clinic. 61
31752720 2019
17
Impact of mass drug administration of azithromycin for trachoma elimination on prevalence and azithromycin resistance of genital Mycoplasma genitalium infection. 61
30981999 2019
18
Gonorrhoea. 61
31754194 2019
19
National Institute of Allergy and Infectious Diseases workshop report: "Chlamydia vaccines: The way forward". 61
29097007 2019
20
High rates of treatment failure for Mycoplasma genitalium among men and women attending a sexual health clinic. 61
31722934 2019
21
The clinical efficacy of garenoxacin for male non-gonococcal urethritis. 61
31757739 2019
22
Resolution of Symptoms and Resumption of Sex After Diagnosis of Nongonococcal Urethritis Among Men Who Have Sex With Men. 61
31356530 2019
23
A case report of necrotizing fasciitis with growth of Actinomyces europaeus and Actinotignum schaalii. 61
31636892 2019
24
Behaviors and Energy Source of Mycoplasma gallisepticum Gliding. 61
31308069 2019
25
Infections caused by Chlamydia trachomatis (including lymphogranuloma venereum) and Mycoplasma genitalium. 61
30878312 2019
26
Invasive Ureaplasma Infection in Patients Receiving Rituximab and Other Humoral Immunodeficiencies-A Case Report and Review of the Literature. 61
31660361 2019
27
[Prevalence and role of IgG anti-Chlamydia trachomatis in a population of infertile men in Morocco]. 61
31473105 2019
28
Hematogenous dissemination of Chlamydia muridarum from the urethra in macrophages causes testicular infection and sperm DNA damage†. 61
31373361 2019
29
Aetiology and prevalence of mixed-infections and mono-infections in non-gonococcal urethritis in men: a case-control study. 61
31515293 2019
30
[Non-gonococcal urethritis in men]. 61
31535818 2019
31
Polymerase chain reaction assay in acute urethritis. 61
31273814 2019
32
The Role of Ureaplasma spp. in the Development of Nongonococcal Urethritis and Infertility among Men. 61
31270127 2019
33
Sexually Transmitted Infections: Prevention, Diagnosis, and Treatment in Primary Care. 61
31505011 2019
34
Roles of Ureaplasma Species in Idiopathic Chronic Prostatitis: A Case-Control Study. 61
30799562 2019
35
Urogenital chlamydia trachomatis treatment failure with azithromycin: A meta-analysis. 61
31646255 2019
36
Mycoplasma genitalium, a stealth female reproductive tract. 61
31522281 2019
37
Hechtia glomerata Zucc: Phytochemistry and Activity of Its Extracts and Major Constituents Against Resistant Bacteria. 61
31546651 2019
38
Evolving patterns of reactive arthritis. 61
30919146 2019
39
Mycoplasma genitalium Nongonococcal Urethritis Is Likely to Increase in Men Who Have Sex With Men Who Practice Unsafe Sex: What Should We Do? 61
31295219 2019
40
Men Who Have Sex With Men With Mycoplasma genitalium-Positive Nongonococcal Urethritis Are More Likely to Have Macrolide-Resistant Strains Than Men With Only Female Partners: A Prospective Study. 61
31295218 2019
41
Gonococcal infection: An unresolved problem. 61
30732970 2019
42
Mycoplasma genitalium macrolide resistance update: Rate among a 2016-2017 cohort of patients in Barcelona, Spain. 61
31445815 2019
43
Community-based strategies to identify the unmet need for care of individuals with sexually transmitted infection-associated symptoms in rural South Africa. 61
31141301 2019
44
Onychocryptosis and asymptomatic external urethritis as complications of oral isotretinoin therapy. 61
31413063 2019
45
Mycoplasma genitalium Infections in Women Attending a Sexually Transmitted Disease Clinic in New Orleans. 61
30351348 2019
46
Migratory Polyarthritis in the Setting of Chlamydial Infection. 61
31565624 2019
47
Management of gonorrhoea in a hospital network: are we following best practice? 61
31292064 2019
48
An overview of reactive arthritis. 61
31169570 2019
49
Detection of Rectal Chlamydia trachomatis in Heterosexual Men Who Report Cunnilingus. 61
31194715 2019
50
Classification of non-gonococcal urethritis: a review. 61
30953260 2019

Variations for Urethritis

Expression for Urethritis

Search GEO for disease gene expression data for Urethritis.

Pathways for Urethritis

Pathways related to Urethritis according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.89 TNF TLR4 TLR2 IL6 CXCL8 CD4
2
Show member pathways
12.81 TNF IL6 HSPD1 CXCL8 CD40LG CD4
3
Show member pathways
12.77 VDAC1 TNF TLR4 TLR2 IL6 CXCL8
4
Show member pathways
12.67 TNF TLR4 TLR2 IL6 CD40LG
5
Show member pathways
12.55 TNF TLR4 TLR2 IL6 CD4
6
Show member pathways
12.53 TNF TLR4 TLR2 IL6 CD40LG CD4
7 12.36 VDAC1 TNF TLR4 CXCL8
8 12.31 VDAC1 TNF IL6 CD4
9
Show member pathways
12.3 TNF MTRR IL6 CRP
10
Show member pathways
12.3 TLR2 DEFB4A DEFA5 CD4
11
Show member pathways
12.29 TNF TLR2 IL6 DEFB4A CXCL8
12 12.26 TNF TLR4 IL6 CXCL8
13
Show member pathways
12.22 TNF TLR4 TLR2 CD40LG
14
Show member pathways
12.21 TNF TLR4 TLR2 IL6 CXCL8
15
Show member pathways
12.19 TNF TLR2 IL6 CXCL8
16 12.18 TNF TLR4 TLR2 IL6 HSPD1
17 12.15 TNF TLR4 TLR2 IL6
18 12.14 TNF IL6 HSPD1 CXCL8
19
Show member pathways
12.02 TNF TLR4 TLR2 IL6 DEFB4A CXCL8
20 11.99 TNF TLR4 IL6 CXCL8
21 11.98 TNF TLR4 IL6 CXCL8
22
Show member pathways
11.97 TNF TLR4 TLR2 IL6 CD4
23 11.96 VDAC1 TNF TLR4 IL6 DEFB4A DEFA5
24
Show member pathways
11.93 TNF TLR4 TLR2 IL6 HSPD1
25 11.88 TNF TLR4 CXCL8 CD40LG
26 11.81 TNF TLR4 TLR2 IL6 CXCL8
27 11.76 TLR4 IL6 CXCL8
28
Show member pathways
11.74 TNF CXCL8 CD40LG
29 11.73 TNF TLR4 IL6 CXCL8
30 11.73 TNF TLR4 TLR2 IL6 CXCL8
31 11.72 TNF IL6 CD4
32 11.71 TNF TLR4 CD4
33 11.63 TNF IL6 CXCL8
34
Show member pathways
11.6 TNF IL6 CXCL8 CD40LG
35 11.5 TNF IL6 CXCL8
36 11.46 TNF TLR4 TLR2 KLK3
37 11.33 TNF TLR4 IL6
38 11.21 TNF IL6 CD4
39 11.19 TNF TLR4 TLR2 IL6 HSPD1 CXCL8
40 10.84 TNF IL6 CXCL8 CRP
41 10.8 TNF TLR4 TLR2 IL6 CXCL8 CD40LG

GO Terms for Urethritis

Cellular components related to Urethritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.63 TNF TLR4 TLR2 HSPD1 CD40LG CD4
2 membrane raft GO:0045121 9.56 VDAC1 TNF TLR2 CD4
3 extracellular space GO:0005615 9.28 TNF KLK3 IL6 HSPD1 DEFB4A DEFA5
4 lipopolysaccharide receptor complex GO:0046696 8.96 TLR4 HSPD1

Biological processes related to Urethritis according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.02 TNF TLR4 TLR2 IL6 CRP
2 inflammatory response GO:0006954 9.98 TNF TLR4 TLR2 IL6 CXCL8 CRP
3 cellular response to lipopolysaccharide GO:0071222 9.89 TNF TLR4 IL6 DEFA5 CXCL8
4 defense response GO:0006952 9.88 TNF DEFB4A DEFA5 CXCL8
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 TNF TLR4 TLR2 IL6 CD40LG
6 immune response GO:0006955 9.86 TNF TLR4 TLR2 IL6 DEFB4A CXCL8
7 defense response to Gram-negative bacterium GO:0050829 9.8 TLR4 IL6 DEFB4A DEFA5 CD4
8 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.79 DEFB4A DEFA5 CXCL8
9 positive regulation of T cell proliferation GO:0042102 9.78 IL6 CD40LG CD4
10 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.77 TNF TLR4 TLR2
11 positive regulation of interferon-gamma production GO:0032729 9.75 TNF TLR4 HSPD1
12 positive regulation of interleukin-6 secretion GO:2000778 9.74 TNF TLR4 TLR2
13 lipopolysaccharide-mediated signaling pathway GO:0031663 9.73 TNF TLR4 TLR2
14 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.72 TLR4 TLR2 HSPD1
15 positive regulation of interleukin-8 production GO:0032757 9.71 TNF TLR4 TLR2
16 positive regulation of interleukin-12 production GO:0032735 9.67 TLR4 TLR2 HSPD1 CD40LG
17 negative regulation of lipid storage GO:0010888 9.63 TNF IL6 CRP
18 cellular response to lipoteichoic acid GO:0071223 9.62 TLR4 TLR2
19 positive regulation of interleukin-10 production GO:0032733 9.62 TLR4 TLR2 HSPD1 CD40LG
20 regulation of immunoglobulin secretion GO:0051023 9.59 TNF CD40LG
21 positive regulation of matrix metallopeptidase secretion GO:1904466 9.52 TLR4 TLR2
22 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.51 TLR4 TLR2
23 positive regulation of chemokine production GO:0032722 9.46 TNF TLR4 TLR2 IL6
24 positive regulation of interleukin-6 production GO:0032755 9.35 TNF TLR4 TLR2 IL6 HSPD1
25 defense response to Gram-positive bacterium GO:0050830 9.1 TNF TLR2 IL6 DEFB4A DEFA5 CRP

Molecular functions related to Urethritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.7 VDAC1 TNF TLR4 TLR2 MRAP CRP
2 cytokine activity GO:0005125 9.56 TNF IL6 CXCL8 CD40LG
3 lipopolysaccharide receptor activity GO:0001875 8.96 TLR4 TLR2
4 lipopolysaccharide binding GO:0001530 8.8 TLR4 TLR2 HSPD1

Sources for Urethritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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