MCID: URT001
MIFTS: 44

Urethritis

Categories: Nephrological diseases

Aliases & Classifications for Urethritis

MalaCards integrated aliases for Urethritis:

Name: Urethritis 12 44 15 17 72
Non-Gonococcal Urethritis 12 72
Nongonococcal Urethritis 12 55
Nonspecific Urethritis 72 33

Classifications:



External Ids:

Disease Ontology 12 DOID:1343
ICD9CM 35 597.80
MeSH 44 D014526
NCIt 50 C26904
SNOMED-CT 68 31822004
UMLS 72 C0041976 C0311389 C1112709

Summaries for Urethritis

MalaCards based summary : Urethritis, also known as non-gonococcal urethritis, is related to urethral syndrome and cervicitis. An important gene associated with Urethritis is DEFB4A (Defensin Beta 4A), and among its related pathways/superpathways are B Cell Development Pathways and Primary immunodeficiency. The drugs Doxycycline and Lymecycline have been mentioned in the context of this disorder. Affiliated tissues include prostate, testes and kidney.

Wikipedia : 75 Urethritis is inflammation of the urethra. The most common symptom is painful or difficult urination. It... more...

Related Diseases for Urethritis

Diseases related to Urethritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 730)
# Related Disease Score Top Affiliating Genes
1 urethral syndrome 33.8 MTRR MT-TG MRAP
2 cervicitis 31.1 YME1L1 MT-TG MRAP HSPD1 DEFB4A
3 pelvic inflammatory disease 30.5 HSPD1 CD40LG
4 urethral stricture 12.8
5 posterior urethral valves 12.7
6 urethral diverticulum 12.7
7 urethral cancer 12.5
8 urethral gland abscess 12.4
9 urethral benign neoplasm 12.4
10 urethral calculus 12.3
11 urethral obstruction sequence 12.3
12 female urethral cancer 12.3
13 urethral villous adenoma 12.3
14 cervical ribs, sprengel anomaly, anal atresia, and urethral obstruction 12.3
15 urethral intrinsic sphincter deficiency 12.3
16 male urethral cancer 12.3
17 anterior urethral valve 12.2
18 urethral false passage 12.2
19 vitiligo, progressive, with mental retardation and urethral duplication 12.2
20 penile urethral cancer 12.2
21 bulbomembranous urethral cancer 12.2
22 urethral urothelial papilloma 12.1
23 urethral verrucous carcinoma 12.1
24 duplication of urethra 12.1
25 infective urethral stricture 12.1
26 prostatic urethral cancer 12.1
27 posterior urethra cancer 12.0
28 urethra leiomyoma 11.9
29 hypospadias 11.8
30 anterior urethra cancer 11.8
31 exstrophy of bladder 11.7
32 atresia of urethra 11.6
33 urethra squamous cell carcinoma 11.6
34 urethra transitional cell carcinoma 11.5
35 urethra cancer 11.5
36 urethra adenocarcinoma 11.5
37 reactive arthritis 11.5
38 cakut 11.4
39 meningococcal infection 11.4
40 transverse myelitis 11.4
41 congenital anomalies of kidney and urinary tract 2 11.4
42 fibroepithelial polyp of urethra 11.4
43 urethra clear cell adenocarcinoma 11.4
44 hypospadias 1, x-linked 11.3
45 vacterl association, x-linked, with or without hydrocephalus 11.3
46 congenital anomalies of kidney and urinary tract 1 11.3
47 proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome 11.2
48 mucoepithelial dysplasia, hereditary 11.1
49 mckusick-kaufman syndrome 11.1
50 testicular regression syndrome 11.1

Comorbidity relations with Urethritis via Phenotypic Disease Network (PDN):


Acute Cystitis Bladder Neck Obstruction
Cystitis Prostate Cancer
Prostatic Hypertrophy Trigonitis
Urethral Stricture

Graphical network of the top 20 diseases related to Urethritis:



Diseases related to Urethritis

Symptoms & Phenotypes for Urethritis

Drugs & Therapeutics for Urethritis

Drugs for Urethritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
2
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
3
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
4 Antiparasitic Agents Phase 4
5 Antimalarials Phase 4
6 Antiprotozoal Agents Phase 4
7 Antibiotics, Antitubercular Phase 4
8
Aztreonam Approved Phase 2, Phase 3 78110-38-0 5742832 5362041
9 Anti-Infective Agents Phase 2, Phase 3
10 Anti-Bacterial Agents Phase 2, Phase 3
11
Tinidazole Approved, Investigational Phase 2 19387-91-8 5479
12 Alkylating Agents Phase 2
13 Amdinocillin Pivoxil Phase 2
14 Renal Agents Phase 2
15 Anti-Infective Agents, Urinary Phase 2
16
Azithromycin Approved 83905-01-5 447043 55185
17
Cefixime Approved, Investigational 79350-37-1 54362 5362065
18 Anesthetics
19 Central Nervous System Depressants

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Study of Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Antibiotic Treatment Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
2 Mycoplasma Genitalium Antibiotic Susceptibility and Treatment: A Randomized Double-blind Trial of the Efficacy of Azithromycin and Doxycycline for Clinical and Microbiological Cure of M. Genitalium in Men With Nongonococcal Urethritis Completed NCT00358462 Phase 3 Azithromycin;Doxycycline
3 Aztreonam for Pharyngeal Gonorrhea: A Demonstration Study Recruiting NCT03867734 Phase 2, Phase 3 Aztreonam
4 Phase II Randomized, Placebo-Controlled Double-Blind 4-Arm Trial for the Treatment of Non-Gonococcal Urethritis (NGU): Doxycycline (Plus or Minus Tinidazole) Versus Azithromycin (Plus or Minus Tinidazole) Completed NCT00322465 Phase 2 Tinidazole;Doxycycline;Azithromycin
5 Prospective Study for Cost-Effectiveness Strategies to Improve Partner Notification: Female Trichomonas and Male Urethritis Studies Completed NCT00207467 Phase 2
6 Mecillinam for Treatment of Genital Chlamydia Infection in Asymptomatic Men Terminated NCT02083276 Phase 2 Pivmecillinamhydrochlorid
7 Study of the Prevalence of a Chronic Inflammatory Condition of the Male Genital Tract at a Distance and Urethritis Following. Completed NCT01732172
8 Antimicrobial Susceptibility Patterns of Neisseria Gonorrhea Isolates in an Era of Quinolone Resistance Completed NCT00692822
9 Expedited Partner Therapy as STI Control Among MSM in Peru Completed NCT01720654
10 Does Thoracic Epidural Analgesia Influence Urinary Micturition by Patients Undergoing Thoracic Surgery? An Observational, Prospective Study Completed NCT00976313
11 Effects of Thoracic Epidural Anesthesia on Lower Urinary Tract Function Completed NCT00790231
12 Clinical Description of Spondylarthritis and Validation of Assessment of SpondyloArthritis International Society (ASAS) Criteria in West Indian Patients Seen in the Routine Consultation of Rheumatology. Recruiting NCT03564743
13 HD5 Levels in Catheter Versus Bag Urine Specimens in Young Children for the Diagnosis of UTI Recruiting NCT03163394
14 Comparison of Current Standard of Care Versus the Australian Guidelines for Management of Mycoplasma Genitalium Infections Among Men Being Treated for Non-gonococcal Urethritis Not yet recruiting NCT03910907 Comparison of two standard of care regimens
15 Do Women Receiving Low Dose Combined Spinal Epidural for Labor Analgesia Exhibit Less Bacteriuria Using a Urinary Retention Protocol Versus Routine Urinary Catheter Placement? Terminated NCT01597791

Search NIH Clinical Center for Urethritis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Azithromycin
Erythromycin
ERYTHROMYCIN PWDR
Flavoxate
Levofloxacin
Metronidazole
Minocycline
Ofloxacin
Tinidazole

Cochrane evidence based reviews: urethritis

Genetic Tests for Urethritis

Anatomical Context for Urethritis

MalaCards organs/tissues related to Urethritis:

41
Prostate, Testes, Kidney, Skin, Pancreas, Cervix, Neutrophil

Publications for Urethritis

Articles related to Urethritis:

(show top 50) (show all 4485)
# Title Authors PMID Year
1
Antibodies to Chlamydia trachomatis heat-shock protein 60 kDa and detection of Mycoplasma genitalium and ureaplasma urealyticum are associated independently with chronic nongonococcal urethritis. 9 38
12567170 2003
2
Polymerase chain reaction assay in acute urethritis. 38
31273814 2019
3
The Role of Ureaplasma spp. in the Development of Nongonococcal Urethritis and Infertility among Men. 38
31270127 2019
4
Roles of Ureaplasma Species in Idiopathic Chronic Prostatitis: A Case-Control Study. 38
30799562 2019
5
Evolving patterns of reactive arthritis. 38
30919146 2019
6
Mycoplasma genitalium Nongonococcal Urethritis Is Likely to Increase in Men Who Have Sex With Men Who Practice Unsafe Sex: What Should We Do? 38
31295219 2019
7
Men Who Have Sex With Men With Mycoplasma genitalium-Positive Nongonococcal Urethritis Are More Likely to Have Macrolide-Resistant Strains Than Men With Only Female Partners: A Prospective Study. 38
31295218 2019
8
Gonococcal infection: An unresolved problem. 38
30732970 2019
9
Community-based strategies to identify the unmet need for care of individuals with sexually transmitted infection-associated symptoms in rural South Africa. 38
31141301 2019
10
Hematogenous dissemination of Chlamydia muridarum from the urethra in macrophages causes testicular infection and sperm DNA damage. 38
31373361 2019
11
Onychocryptosis and asymptomatic external urethritis as complications of oral isotretinoin therapy. 38
31413063 2019
12
Behaviors and energy source of Mycoplasma gallisepticum gliding. 38
31308069 2019
13
Mycoplasma genitalium: A Review. 38
31329090 2019
14
Management of gonorrhoea in a hospital network: are we following best practice? 38
31292064 2019
15
An overview of reactive arthritis. 38
31169570 2019
16
Detection of Rectal Chlamydia trachomatis in Heterosexual Men Who Report Cunnilingus. 38
31194715 2019
17
Resolution of symptoms and resumption of sex after diagnosis of nongonococcal urethritis among men who have sex with men. 38
31356530 2019
18
Classification of non-gonococcal urethritis: a review. 38
30953260 2019
19
Lack of association between the S83I ParC mutation in Mycoplasma genitalium and treatment outcomes among men who have sex with men with nongonococcal urethritis. 38
31259853 2019
20
Mycoplasma genitalium nongonococcal urethritis is likely to increase in men who have sex with men who practice unsafe sex: What should we do? 38
31188279 2019
21
Long Duration of Asymptomatic Mycoplasma genitalium Infection After Syndromic Treatment for Nongonococcal Urethritis. 38
30281079 2019
22
Estimate of male urethritis incidences in France between 2007 and 2017 with a specific focus on Neisseria gonorrhoeae, Chlamydia trachomatis, and Trichomonas vaginalis infections. 38
31248368 2019
23
Selected Immunological Mediators and Cervical Microbial Signatures in Women with Chlamydia trachomatis Infection. 38
31164450 2019
24
Cross-sectional study of urethral exposures at last sexual episode associated with non-gonococcal urethritis among STD clinic patients. 38
30181326 2019
25
Recreational drugs and STI diagnoses among patients attending an STI/HIV reference clinic in Rome, Italy. 38
31101722 2019
26
Neonatal Conjunctivitis Caused by Neisseria meningitidis US Urethritis Clade, New York, USA, August 2017. 38
31002061 2019
27
Delay in Seeking Health Care Services After Onset of Urethritis Symptoms in Men. 38
30985634 2019
28
Homophobia and heteronormativity as dimensions of stigma that influence sexual risk behaviors among men who have sex with men (MSM) and women (MSMW) in Lima, Peru: a mixed-methods analysis. 38
31113398 2019
29
A 'pathogenic needle' in a 'commensal haystack': Genetic virulence signatures of Corynebacterium glucuronolyticum that may drive its infectious propensity for the male urogenital system. 38
31010496 2019
30
Sexual behavior and sexually transmitted infection in the elderly population of South Korea. 38
31098428 2019
31
Disseminated adenovirus infection in a patient with relapsed refractory multiple myeloma undergoing autologous stem cell transplantation and pomalidomide/dexamethasone as salvage regimens. 38
30642772 2019
32
Chlamydia trachomatis and Chlamydia pneumoniae Interaction with the Host: Latest Advances and Future Prospective. 38
31100923 2019
33
Ureaplasma urealyticum pyelonephritis presenting with progressive dysuria, renal failure, and neurologic symptoms in an immunocompromised patient. 38
30472777 2019
34
Impact of mass drug administration of azithromycin for trachoma elimination on prevalence and azithromycin resistance of genital Mycoplasma genitalium infection. 38
30981999 2019
35
Symptoms, Sites, and Significance of Mycoplasma genitalium in Men Who Have Sex with Men. 38
30882306 2019
36
Mycoplasma genitalium in symptomatic male urethritis: macrolide use is associated with increased resistance. 38
30972419 2019
37
Is it time for the US and Canada to reconsider macrolides as the first line empiric treatment for males with symptomatic urethritis? 38
30972414 2019
38
Men who have sex with men with Mycoplasma genitalium-positive nongonococcal urethritis are more likely to have macrolide resistant strains than men with only female partners: a prospective study. 38
31008841 2019
39
Failure of syndromic management due to drug-resistant Mycoplasma genitalium infection in South Africa: a case report. 38
30714876 2019
40
[Medical prevention and treatment of radiation-induced urological and nephrological complications]. 38
30898418 2019
41
Two cases of multidrug-resistant genitourinary Mycoplasma genitalium infection successfully eradicated with minocycline. 38
30999836 2019
42
Evaluation of Susceptibilities to Carbapenems and Faropenem Against Cephalosporin-Resistant Neisseria gonorrhoeae Clinical Isolates with penA Mosaic Alleles. 38
30676251 2019
43
Rationale for a Neisseria gonorrhoeae Susceptible Only Interpretive Breakpoint for Azithromycin. 38
30963175 2019
44
[Management of urethral stones in dogs using pneumatic and laser lithotripsy]. 38
31013525 2019
45
Primary Syphilis in the Male Urethra: A Case Report. 38
30202933 2019
46
Infections caused by Chlamydia trachomatis (including lymphogranuloma venereum) and Mycoplasma genitalium. 38
30878312 2019
47
Outcomes of Resistance-guided Sequential Treatment of Mycoplasma genitalium Infections: A Prospective Evaluation. 38
29873691 2019
48
A microbial game of whack-a-mole: clinical case series of the urethral uncloaking phenomenon caused by Corynebacterium glucuronolyticum in men treated for Chlamydia trachomatis urethritis. 38
30168068 2019
49
Haemophilus Species Isolated in Urethral Exudates as a Possible Causative Agent in Acute Urethritis: A Study of 38 Cases. 38
30390917 2019
50
Naphthalene induced acute kidney injury in an African patient in Ghana: a case report. 38
31312313 2019

Variations for Urethritis

Expression for Urethritis

Search GEO for disease gene expression data for Urethritis.

Pathways for Urethritis

Pathways related to Urethritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.68 CD40LG CD4
2 10.19 CD40LG CD4

GO Terms for Urethritis

Biological processes related to Urethritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.56 YME1L1 MNAT1 HSPD1 CD40LG
2 positive regulation of T cell proliferation GO:0042102 9.4 CD40LG CD4
3 T cell activation GO:0042110 9.37 HSPD1 CD4
4 B cell proliferation GO:0042100 9.32 HSPD1 CD40LG
5 positive regulation of interleukin-12 production GO:0032735 9.16 HSPD1 CD40LG
6 positive regulation of T cell activation GO:0050870 8.96 HSPD1 CD4
7 positive regulation of interleukin-10 production GO:0032733 8.62 HSPD1 CD40LG

Sources for Urethritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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