MCID: URT001
MIFTS: 52

Urethritis

Categories: Nephrological diseases

Aliases & Classifications for Urethritis

MalaCards integrated aliases for Urethritis:

Name: Urethritis 12 44 15 17 70
Non-Gonococcal Urethritis 12 70
Nongonococcal Urethritis 12 54
Nonspecific Urethritis 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:1343
ICD9CM 34 597.80
MeSH 44 D014526
NCIt 50 C26904
SNOMED-CT 67 154388003 31822004
UMLS 70 C0041976 C0311389 C1112709

Summaries for Urethritis

MalaCards based summary : Urethritis, also known as non-gonococcal urethritis, is related to haemophilus influenzae and pyuria. An important gene associated with Urethritis is DEFB4A (Defensin Beta 4A), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Azithromycin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include prostate, skin and pancreas, and related phenotype is integument.

Wikipedia : 73 Urethritis is the inflammation of the urethra. The most common symptoms include painful or difficult... more...

Related Diseases for Urethritis

Diseases related to Urethritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 841)
# Related Disease Score Top Affiliating Genes
1 haemophilus influenzae 30.7 TNF TLR2 CXCL8
2 pyuria 30.7 KLK3 IL6 CXCL8 CRP
3 urethral syndrome 30.6 TNF MTRR KLK3 IL6 IL1B EPPIN
4 syphilis 30.4 TNF IL6 CRP CD8A CD4
5 urinary tract infection 30.3 TLR4 CRP
6 prostatitis 30.2 TNF KLK3 IL6 IL1B IL10 CXCL8
7 vulvovaginitis 30.2 IL10 HSPD1 CXCL8
8 latent syphilis 30.1 CD8A CD4
9 cystitis 30.1 TNF TLR4 IL6 CXCL8 CRP
10 microsporidiosis 30.1 DEFB4A DEFA5 CD4
11 pelvic inflammatory disease 30.0 TLR4 TLR2 HSPD1 EPPIN CRP
12 conjunctivitis 30.0 TNF TLR4 IL6 IL10 CXCL8
13 primary syphilis 30.0 CRP CD8A CD4
14 acute gonococcal cervicitis 30.0 IL6 IL10 CXCL8
15 genital herpes 30.0 TLR2 IL10 CD8A CD4
16 ophthalmia neonatorum 30.0 MTRR MTR
17 trachoma 29.9 TNF IL6 IL10
18 chlamydia 29.9 TNF TLR4 TLR2 IL6 IL1B IL10
19 diverticulitis 29.9 TNF IL6 CRP
20 anogenital venereal wart 29.8 TLR4 CD8A CD4
21 salpingitis 29.8 TNF TLR2 IL6 HSPD1 CRP CD4
22 proctitis 29.8 TNF KLK3 CRP
23 trichomoniasis 29.8 TNF IL6 IL1B IL10 EPPIN CXCL8
24 reactive arthritis 29.7 TNF TLR4 TLR2 IL6 IL1B IL10
25 acne 29.6 TNF TLR2 IL6 IL1B DEFB4A CXCL8
26 bacteriuria 29.5 TLR4 TLR2 IL6 CXCL8 CRP
27 stomatitis 29.4 TNF IL6 IL1B IL10 CXCL8 CD4
28 helicobacter pylori infection 29.4 TNF IL1B IL10 CXCL8
29 spondyloarthropathy 29.4 TNF IL6 IL1B IL10
30 synovitis 29.4 TNF IL6 IL1B CXCL8 CRP
31 placenta disease 29.3 TNF IL6 IL1B CXCL8 CRP
32 cervicitis 29.2 TNF TLR4 MAPK1IP1L IL6 IL1B IL10
33 tenosynovitis 29.2 TNF IL6 IL1B HSPD1 CRP CD4
34 cellulitis 29.2 TNF IL6 DEFB4A CRP CD8A CD4
35 hemorrhagic cystitis 29.1 TNF TLR4 CD8A CD4
36 urticaria 29.1 TNF IL6 IL10 CXCL8 CRP CD4
37 vaginitis 29.1 TNF TLR2 IL6 IL1B IL10 EPPIN
38 granulomatosis with polyangiitis 29.0 TNF TLR4 TLR2 CRP CD4
39 vaginal discharge 29.0 TNF IL6 IL1B IL10 CXCL8 CRP
40 dysentery 29.0 TNF IL6 IL1B IL10 CXCL8 CRP
41 amebiasis 28.9 TNF TLR2 IL1B IL10 CXCL8 CD4
42 septic arthritis 28.9 TNF TLR4 TLR2 DEFB4A CXCL8 CRP
43 endometritis 28.9 TNF TLR4 TLR2 IL6 IL1B CXCL8
44 endocarditis 28.9 TNF TLR2 IL6 IL10 HSPD1 CXCL8
45 pharyngitis 28.7 TNF IL6 IL1B CXCL8 CRP CD8A
46 orchitis 28.7 TNF IL6 IL1B IL10 EPPIN CRP
47 diarrhea 28.7 TNF TLR4 IL6 IL1B IL10 CXCL8
48 bacterial vaginosis 28.6 TNF TLR4 TLR2 IL6 IL1B IL10
49 candidiasis 28.5 TNF TLR4 TLR2 IL6 IL1B IL10
50 acute cystitis 28.5 TNF TLR4 KLK3 IL6 IL1B IL10

Comorbidity relations with Urethritis via Phenotypic Disease Network (PDN):


Acute Cystitis Bladder Neck Obstruction
Cystitis Prostate Cancer
Prostatic Hypertrophy Trigonitis
Urethral Stricture

Graphical network of the top 20 diseases related to Urethritis:



Diseases related to Urethritis

Symptoms & Phenotypes for Urethritis

MGI Mouse Phenotypes related to Urethritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.28 CD4 CD8A HSPD1 IL10 IL1B IL6

Drugs & Therapeutics for Urethritis

Drugs for Urethritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 182)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 447043 55185
2
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
3
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
4
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
5
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
6
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
7
Sulfamethoxazole Approved Phase 4 723-46-6 5329
8
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
9
Nitrofurantoin Approved, Vet_approved Phase 4 67-20-9 5353830
10
Goserelin Approved Phase 4 65807-02-5 47725 5311128
11
Dutasteride Approved, Investigational Phase 4 164656-23-9 6918296 152945
12
tannic acid Approved Phase 4 1401-55-4
13
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
14
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
15
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
16
Dehydroepiandrosterone Approved, Investigational, Nutraceutical Phase 4 53-43-0 5881
17
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
18 Antirheumatic Agents Phase 4
19 DHEA (Dehydroepiandrosterone) Phase 4
20 Cyclooxygenase Inhibitors Phase 4
21 Anti-Inflammatory Agents, Non-Steroidal Phase 4
22 Antimalarials Phase 4
23 Antiparasitic Agents Phase 4
24 Anti-Infective Agents Phase 4
25 Antiprotozoal Agents Phase 4
26 Solifenacin succinate Phase 4 242478-38-2
27 Folic Acid Antagonists Phase 4
28 Vitamin B9 Phase 4
29 Vitamin B Complex Phase 4
30 Folate Phase 4
31 Cytochrome P-450 Enzyme Inhibitors Phase 4
32 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
33 5-alpha Reductase Inhibitors Phase 4
34 Adrenergic Agents Phase 4
35 Adrenergic alpha-Agonists Phase 4
36 Adrenergic beta-Agonists Phase 4
37 Vasoconstrictor Agents Phase 4
38 Respiratory System Agents Phase 4
39 Anti-Asthmatic Agents Phase 4
40 Mydriatics Phase 4
41 Sympathomimetics Phase 4
42 Adrenergic Agonists Phase 4
43 Bronchodilator Agents Phase 4
44 Anesthetics Phase 4
45 Anti-Arrhythmia Agents Phase 4
46 Sodium Channel Blockers Phase 4
47 Analgesics, Non-Narcotic Phase 4
48 Analgesics Phase 4
49 Diuretics, Potassium Sparing Phase 4
50 Anesthetics, Local Phase 4

Interventional clinical trials:

(show top 50) (show all 293)
# Name Status NCT ID Phase Drugs
1 Study of Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Antibiotic Treatment Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
2 Cold vs. Laser Internal Urethrotomy Treatment of Urethral Strictures Unknown status NCT01196572 Phase 4
3 Open-Label Vulvoscopy Photography Study of Changes in Vulva, Vestibule, Urethral Meatus and Vagina 20 Weeks Post Daily Administration of 6.5 Mg Vaginal Prasterone in Menopausal Women With Moderate to Severe Dyspareunia Unknown status NCT03568604 Phase 4 Prasterone
4 The Effect of Preemptive Analgesia On The Comfort Of Patient and Doctor, in Cystoscopy Unknown status NCT03831321 Phase 4 Diclofenac Sodium;Lubricant Gel
5 TVT-Secur Versus TVT-Obturator: A Randomized Trial of Suburethral Sling Operative Procedures Unknown status NCT00676273 Phase 4
6 Post-Marketing Study Using PROLIEVE® for the Treatment of Benign Prostatic Hyperplasia (BPH) Unknown status NCT02021032 Phase 4
7 A Comparison Among Three Single-incision Devices for the Treatment of Female Urinary Genuine Stress Incontinence: a Randomized Controlled Study. Completed NCT00751088 Phase 4
8 TOMUS-Trial Of Mid-Urethral Slings Completed NCT00325039 Phase 4
9 Evaluating the Change of Overactive Bladder Symptoms in Women Post Pubovaginal Sling Procedure for Stress Incontinence Completed NCT01194999 Phase 4
10 The Impact of Liposomal Bupivacaine Administered Following Placement of a Retropubic Suburethral Sling for Stress Urinary Incontinence: a Randomized Placebo-controlled Trial Completed NCT02296099 Phase 4 liposomal bupivacaine;Placebo
11 Use of Antibiotic Prophylaxis on Urethral Catheter Withdrawal: A Randomized Double-Blind Placebo-Controlled Trial Completed NCT00126698 Phase 4 trimethoprim-sulfamethoxazole;ciprofloxacin
12 Global Performance Evaluation of the AMS CONTINUUM™ Device in Facilitating Vesico-Urethral Anastomosis Following a Radical Prostatectomy Completed NCT01083199 Phase 4
13 Evaluation of the Efficacy on Urinary Continence and Quality of Life of the Sub-urethral Tape I-STOP® Using the Transobturator and Perineal Route on Male Incontinent After Radical Prostatectomy. Completed NCT00442078 Phase 4
14 Double Blinded Randomized Trial Between Lidocaine Jelly And Plain Aqueous Gel For Urethral Straight Catheterization And The Q-Tip Test Completed NCT00883103 Phase 4 2% Lidocaine jelly;Plain aqueous gel
15 Does Prophylaxis With Macrobid Reduce the Incidence of Urinary Tract Infection in Patients Who Receive a Sub-Urethral Sling for the Treatment of Stress Urinary Incontinence: Randomized, Double Blinded Placebo Controlled Clinical Trial Completed NCT00734968 Phase 4 Nitrofurantoin
16 A Randomized Comparison of Concomitant Incontinence Procedures Performed With Abdominal Sacral Colpopexy: the Burch Versus Mid-urethral Sling Trial Completed NCT00934999 Phase 4
17 Randomized, Double-Blind, Placebo-Controlled Trial Assessing The Efficacy And Safety Of Dutasteride At Improving Lower Urinary Tract Symptoms In Men With Clinically Localized Prostate Cancer Being Treated With Single-Dose Goserelin, Trans-Urethral Incision Of Prostate, And Interval Brachytherapy Completed NCT00805701 Phase 4 avodart;Placebo
18 The Impact of Retropubic Lidocaine vs Saline on Postoperative Urinary Retention Following Midurethral Sling: A Randomized Placebo Controlled Trial Recruiting NCT03913845 Phase 4 lidocaine with epinephrine;Normal saline with epinephrine
19 Lessons on Urethral Lidocaine in Urodynamics (LULU): Impact of Intraurethral Lidocaine on Cystometric Parameters and Discomfort Recruiting NCT04038099 Phase 4 Water-Based Vaginal Lubricant;lidocaine topical
20 Nitrous Oxide for Analgesia During Office Urethral Bulking: a Randomized, Controlled Trial Terminated NCT03847922 Phase 4 Nitrous Oxide + Oxygen Gas (Product);lidocaine gel 2%
21 A Comparison in Terms of Efficacy and Safety Between Transobturator and Transvaginal Tape Performed at the Same Time of Anterior Defect Correction With Mesh Terminated NCT00743535 Phase 4
22 Study of a Urethral Catheter Coated With Eluting Silver Salts Terminated NCT00482547 Phase 4
23 Diagnosis of Urethral Stricture With Sono-urethrography vs Conventional Urethrography: Evaluation of the Diagnostic Value and Evaluation of the Reduction of the Radiation Dose With Sono-urethrography (SONO-URETHRA) Unknown status NCT01790776 Phase 3
24 Liposomal Bupivacaine To Control Post-Operative Pain Following Buccal Mucosal Graft Harvesting Unknown status NCT03720223 Phase 3 Liposomal Bupivacaine
25 Radiofrequency in the Female Stress Urinary Incontinence: A Randomized Clinical Trial Unknown status NCT02617797 Phase 2, Phase 3
26 A Pilot Study of the Safety, Acceptability, Behavior Impact, and HIV Seroincidence Among High Risk Men Who Have Sex With Men With Access to Isentress 400 mg BID + Truvada Once Daily for Peri-exposure Chemoprophylaxis for HIV Infection Chemoprophylaxis for HIV Infection Unknown status NCT01697046 Phase 3 Truvada and Isentress
27 Mycoplasma Genitalium Antibiotic Susceptibility and Treatment: A Randomized Double-blind Trial of the Efficacy of Azithromycin and Doxycycline for Clinical and Microbiological Cure of M. Genitalium in Men With Nongonococcal Urethritis Completed NCT00358462 Phase 3 Azithromycin;Doxycycline
28 A Two Paramedian Vaginal Incisions Versus the Standard Longitudinal Incision of Trans-Obturator Tape Procedure for Management of Urinary Incontinence Completed NCT04571346 Phase 2, Phase 3
29 A Randomised Controlled Trial Comparing TVT, Pelvicol and Autologous Fascial Slings for the Treatment of Stress Urinary Incontinence in Women Completed NCT01057550 Phase 3
30 Open-label, Multi-center, Single Arm Study to Evaluate the Efficacy and Safety of Periurethral Injection of Autologous Adipose Derived Regenerative Cells (ADRCs) for the Treatment of Male Stress Urinary Incontinence Completed NCT02529865 Phase 3
31 A Randomized Trial Comparing Tension-free Vaginal Tape (TVT) to the TVT-SECUR for the Surgical Treatment of Stress Urinary Incontinence Completed NCT00534365 Phase 3
32 Prospective, Randomized, Controlled, Multicenter Trial of the Memokath® 044TW Thermo-Expandable Stent for Maintaining Urethral Patency in Patients After Dilation or Internal Urethrotomy of Recurrent Stricture of the Bulbar Urethra Completed NCT00270504 Phase 3
33 Holmium: YAG Versus Cold Knife Internal Urethrotomy in Management of Short Urethral Strictures: A Randomized Controlled Trial Completed NCT04650347 Phase 2, Phase 3
34 The Effect of Oral phenazopyrIdine on Perioperative Voiding After Mid-urethral Sling Completed NCT02806713 Phase 3 Phenazopyridine
35 Is There Any Value of Concomitant Repair of Asymptomatic Grade II Anterior Vaginal Wall Prolapse During Mid Urethral Sling Surgery for Stress Urinary Incontinence ? Completed NCT03296748 Phase 2, Phase 3
36 Open Label Pilot Study to Treat Women With Chronic Urinary Retention or Voiding Dysfunction Due to a Primary Disorder of Sphincter Relaxation (Fowler's Syndrome) With Outpatient Urethral Injections of Botulinum Toxin A (BoNT-A) Completed NCT02428881 Phase 2, Phase 3 onabotulinumtoxinA
37 Holmium Laser Enucleation of the Prostate Versus Bipolar Transurethral Enucleation of the Prostate in Management of Benign Prostatic Hyperplasia A Randomized Controlled Trial Completed NCT04275076 Phase 3
38 URINARY INCONTINENCE AND URO-GENITAL PROLAPSE: A RANDOMIZED TRIAL OF PELVIC ORGAN PROLAPSE REPAIR PLUS MINI-SLING VERSUS PELVIC ORGAN PROLAPSE REPAIR ALONE Completed NCT01384084 Phase 3
39 Glans Penis Augmentation by Hyaluronic Acid for Treatment of Premature Ejaculation: Randomized Controlled Cross-over Trial Completed NCT03459833 Phase 3 Hyaluronic Acid
40 Periurethral Hypertonic Saline (10%) Injection for Female Stress Urinary Incontinence and Stress-Predominant Mixed Urinary Incontinence Completed NCT04812574 Phase 3 Hypertonic (10%) saline
41 Comparisons of the Impact of Duloxetine Versus Imipramine on Therapeutic Efficacy, Psychological Distress, Sexual Function, Urethral and Bladder Wall Structure and Blood Flow in Women With Stress Urinary Incontinence: a Randomized Controlled Study Recruiting NCT04412876 Phase 3 Duloxetine;Imipramine
42 Treatment for Mixed Urinary Incontinence: Mid-urethral Sling vs. Botox A Recruiting NCT04171531 Phase 3 Botox® injection
43 PASTIS-Trial: Pre-operative Assessment by Sonourethrography Only in Anterior Urethral Strictures: A Prospective Feasibility Trial Not yet recruiting NCT04452890 Phase 3
44 Vaginal Prolapse Surgery Accompanied by Mid Urethral Sling Versus no Sling for Reduction of Postoperative Incontinence: a Randomized Controlled Trial Not yet recruiting NCT04251923 Phase 2, Phase 3
45 Injection of Botulinum Toxin Type A Into the External Urethral Sphincter for Male Patients Suffering From Chronic Prostatitis/Chronic Pelvic Pain Syndrome (NIH Cat. III): a Prospective, Double-blind and Placebo-controlled Clinical Trial Terminated NCT00464373 Phase 3 Botulinum Toxin Type A;Placebo
46 Management of Urethral Injury During Penile Prosthesis Implantation: Urethral Sterilization With Chlorhexidine Digluconate to Facilitate Primary Repair and Same-Session Implantation Unknown status NCT03614429 Phase 2 Chlorhexidine gel will be prepared according to an international product Instillagel®
47 Effectiveness and Safety of Endoscopically-Assisted Submucosal Administration of Autologous Adipose-Derived Regenerative Cells for the Treatment of Urethral Strictures Unknown status NCT01889888 Phase 1, Phase 2
48 Effect of Mitomycin C on Urethral Stricture Recurrence After Internal Urethrotomy Unknown status NCT00918528 Phase 1, Phase 2 Mitomycin C - local injection
49 A Double Blind Placebo Controlled Trial of Autologous Platelet Rich Plasma (PRP) Peri-urethral and Clitoral Injections for the Treatment of Female Orgasmic Disorder Unknown status NCT03189238 Phase 2
50 Autologous Muscle Fiber Transplantation for Repair of the Urethral Sphincter in Patients With Stress Urinary Incontinence Unknown status NCT01323426 Phase 1, Phase 2

Search NIH Clinical Center for Urethritis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


ERYTHROMYCIN PWDR

Cochrane evidence based reviews: urethritis

Genetic Tests for Urethritis

Anatomical Context for Urethritis

MalaCards organs/tissues related to Urethritis:

40
Prostate, Skin, Pancreas, Spinal Cord, Cervix, Bone, Colon

Publications for Urethritis

Articles related to Urethritis:

(show top 50) (show all 4615)
# Title Authors PMID Year
1
Antibodies to Chlamydia trachomatis heat-shock protein 60 kDa and detection of Mycoplasma genitalium and ureaplasma urealyticum are associated independently with chronic nongonococcal urethritis. 54 61
12567170 2003
2
Towards understanding antimicrobial activity, cytotoxicity and the mode of action of dichapetalins A and M using in silico and in vitro studies. 61
33493498 2021
3
The JAID/JSC guidelines to Clinical Management of Infectious Disease 2017 concerning male urethritis and related disorders. 61
33516669 2021
4
Resistance-guided treatment of Mycoplasma genitalium infection at a UK sexual health centre. 61
33755520 2021
5
A Narrative Review of the W, X, Y, E, and NG of Meningococcal Disease: Emerging Capsular Groups, Pathotypes, and Global Control. 61
33802567 2021
6
Proteome wide vaccine targets prioritization and designing of antigenic vaccine candidate to trigger the host immune response against the Mycoplasma genitalium infection. 61
33524568 2021
7
Main etiological agents identified in 170 men with urethritis attended at the Fundação Alfredo da Matta, Manaus, Amazonas, Brazil. 61
33640187 2021
8
Penile amputation and pre-scrotal urethrostomy in a male guinea pig (Cavia porcellus). 61
33314080 2021
9
Emergence of a novel urogenital-tropic Neisseria meningitidis. 61
33278178 2021
10
Retrospective study of proliferative urethritis in dogs: Clinical presentation and outcome using various treatment modalities in 11 dogs. 61
33316119 2021
11
CT and MRI in Urinary Tract Infections: A Spectrum of Different Imaging Findings. 61
33401464 2021
12
Phytochemistry and Pharmacology of the Genus Equisetum (Equisetaceae): A Narrative Review of the Species with Therapeutic Potential for Kidney Diseases. 61
33747109 2021
13
Sexually Transmitted Infection Diagnoses and Access to a Sexual Health Service Before and After the National Lockdown for COVID-19 in Melbourne, Australia. 61
33506064 2021
14
Clinical profile and co-infections of urethritis in males. 61
33423450 2021
15
Prevalence of urogenital, anal, and pharyngeal infections with Chlamydia trachomatis, Neisseria gonorrhoeae, and Mycoplasma genitalium: a cross-sectional study in Reunion island. 61
33478403 2021
16
Genomic Characterization of Emerging Bacterial Uropathogen Neisseria meningitidis, Which Was Misidentified as Neisseria gonorrhoeae by Nucleic Acid Amplification Testing. 61
33177123 2021
17
[Brazilian Protocol for Sexually Transmitted Infections 2020: infections that cause urethral discharge]. 61
33729412 2021
18
[The use of alfuzosin in the treatment of patients with acute urinary retention]. 61
33377680 2020
19
Acute urinary retention in children. 61
32900634 2020
20
Single-Arm Open-Label Clinical Trial of Two Grams of Aztreonam for the Treatment of Neisseria gonorrhoeae. 61
33077658 2020
21
Prescrotal urethrotomy for urethroscopic ablation of a hemorrhagic urethral mucosal mass. 61
33299247 2020
22
MYCO WELL D-ONE detection of Ureaplasma spp. and Mycoplasma hominis in sexual health patients in Wales. 61
32725499 2020
23
Euphorbia urethritis: The minor scourge of the Garden Spurge. 61
32469623 2020
24
Prevalence of Mycoplasma genitalium Infection, Antimicrobial Resistance Mutations, and Symptom Resolution Following Treatment of Urethritis. 61
32185385 2020
25
Alternative conformation of the C-domain of the P140 protein from Mycoplasma genitalium. 61
33135669 2020
26
Haemophilus spp., an emerging multidrug-resistant sexually transmitted pathogen. 61
32569798 2020
27
Full Molecular Typing of Neisseria meningitidis Directly from Clinical Specimens for Outbreak Investigation. 61
32938738 2020
28
Neisseria meningitidis Urethritis Outbreak Isolates Express a Novel Factor H Binding Protein Variant That Is a Potential Target of Group B-Directed Meningococcal (MenB) Vaccines. 61
32958529 2020
29
[The efficiency of combination therapy of non-gonococcal urethritis in men]. 61
33185339 2020
30
Single-Inclusion Kinetics of Chlamydia trachomatis Development. 61
33051378 2020
31
Multimorbidity Among Adult Outpatients With Type 1 Diabetes in Germany. 61
33095037 2020
32
Idiopathic hemorrhagic urethritis of childhood. 61
32762951 2020
33
New Approach to Microscopy of Gram-Stained Urethral Smear: The Kissing Slide Method. 61
32649578 2020
34
Azithromycin, minocycline, moxifloxacin and spectinomycin failure in a case with persistent Mycoplasma genitalium infection in Guangzhou, China. 61
32842908 2020
35
The first human case of babesiosis mimicking Reiter's syndrome. 61
33173020 2020
36
Effects of Urethritis on HIV in Semen: Implications for HIV Prevention and Cure. 61
33033831 2020
37
Human Adenovirus B7d-Associated Urethritis after Suspected Sexual Transmission, Japan. 61
32946724 2020
38
Azithromycin combined with doxycycline in non-gonococcal urethritis. 61
32905367 2020
39
Male urethritis. A review of the ideal diagnostic method. 61
32684296 2020
40
INCIDENCE OF NON-GONOCOCCAL URETHRITIS (NGU) IN MEN WHO HAVE SEX WITH WOMEN (MSW) AND ASSOCIATED RISK FACTORS. 61
33044377 2020
41
Comparison of gentamicin MICs by agar dilution and Etest for clinical isolates of Neisseria gonorrhoeae. 61
32544235 2020
42
Mycoplasma genitalium coinfection in men with symptomatic gonococcal urethritis. 61
32912933 2020
43
Reactive arthritis after COVID-19 infection. 61
32763956 2020
44
Prevalence of Mycoplasma genitalium and Antibiotic Resistance-Associated Mutations in Patients at a Sexually Transmitted Infection Clinic in Iceland, and Comparison of the S-DiaMGTV and Aptima Mycoplasma genitalium Assays for Diagnosis. 61
32611793 2020
45
Urethral microbiota in men: Association of Haemophilus influenzae and Mycoplasma penetrans with nongonococcal urethritis. 61
32750107 2020
46
Male urethritis of unknown etiology: Piecing together the puzzle. 61
32750148 2020
47
Structure and mechanism of the Nap adhesion complex from the human pathogen Mycoplasma genitalium. 61
32513917 2020
48
Identification of a Cytopathogenic Toxin from Sneathia amnii. 61
32291280 2020
49
The frontiers of addressing antibiotic resistance in Neisseria gonorrhoeae. 61
32119845 2020
50
Meningococcal disease and sexual transmission: urogenital and anorectal infections and invasive disease due to Neisseria meningitidis. 61
32534649 2020

Variations for Urethritis

Expression for Urethritis

Search GEO for disease gene expression data for Urethritis.

Pathways for Urethritis

Pathways related to Urethritis according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.07 TNF TLR4 TLR2 IL6 IL1B IL10
2
Show member pathways
13.45 TNF TLR4 TLR2 IL6 IL1B IL10
3
Show member pathways
13.26 TNF TLR4 TLR2 IL6 IL1B IL10
4
Show member pathways
13 TNF TLR4 TLR2 IL6 IL1B CXCL8
5
Show member pathways
12.93 TNF IL6 IL1B IL10 HSPD1 CXCL8
6
Show member pathways
12.88 TNF TLR4 TLR2 IL6 IL1B CXCL8
7
Show member pathways
12.81 TNF TLR4 TLR2 IL6 IL1B CXCL8
8
Show member pathways
12.79 TNF TLR4 TLR2 IL6 IL1B CXCL8
9
Show member pathways
12.74 TNF TLR4 TLR2 IL6 IL1B
10
Show member pathways
12.68 TNF TLR4 TLR2 IL6 IL1B IL10
11
Show member pathways
12.68 TNF TLR4 TLR2 IL6 IL1B IL10
12
Show member pathways
12.64 TNF IL6 IL1B IL10 CD4
13 12.62 TNF TLR2 IL1B IL10 CD8A
14
Show member pathways
12.43 TNF TLR2 IL6 IL1B DEFB4A CXCL8
15
Show member pathways
12.43 TNF MTRR MTR IL6 IL1B CRP
16 12.41 TNF TLR4 IL1B CXCL8
17
Show member pathways
12.41 TLR2 EPPIN DEFB4A DEFA5 CD4
18
Show member pathways
12.38 TNF TLR4 IL6 IL1B CXCL8
19
Show member pathways
12.36 TNF IL6 IL10 CXCL8
20
Show member pathways
12.35 TNF TLR4 TLR2 IL6 CXCL8
21
Show member pathways
12.34 TNF TLR4 TLR2 IL1B IL10
22
Show member pathways
12.31 TNF IL6 IL1B IL10 CXCL8
23 12.3 TNF TLR4 IL6 IL1B DEFB4A DEFA5
24 12.28 TNF IL6 IL1B IL10 HSPD1 CXCL8
25 12.28 TNF TLR4 TLR2 IL6 IL1B IL10
26
Show member pathways
12.25 TNF IL6 IL1B IL10
27 12.23 TNF TLR4 TLR2 IL6
28
Show member pathways
12.19 TNF TLR4 TLR2 IL6 IL1B DEFB4A
29 12.12 TNF TLR4 IL6 IL1B CXCL8
30 12.1 TNF IL6 IL10 CD8A CD4
31 12.09 TNF IL6 IL1B IL10 CXCL8
32 12.02 TNF IL6 IL1B CD8A CD4
33 12.01 TNF TLR4 IL1B CXCL8
34 11.99 TNF IL6 IL1B CXCL8
35
Show member pathways
11.97 TLR4 TLR2 IL6 IL1B CD4
36 11.97 TNF TLR4 TLR2 IL6 IL1B CXCL8
37 11.91 TNF IL1B IL10 CD8A CD4
38 11.89 TNF TLR4 IL6 IL1B IL10 CXCL8
39 11.87 TNF TLR4 TLR2 IL6 IL1B IL10
40 11.79 TNF TLR4 TLR2 IL6 IL10
41
Show member pathways
11.76 TNF IL6 IL1B CXCL8
42 11.76 TNF TLR4 IL6 IL1B IL10 CXCL8
43 11.75 TNF IL6 IL1B CXCL8
44 11.71 TNF IL6 IL1B IL10 CD8A CD4
45
Show member pathways
11.68 TNF TLR4 TLR2 IL6 IL1B IL10
46 11.65 TNF IL6 IL1B IL10 CXCL8
47 11.63 TNF TLR4 TLR2 KLK3 IL1B
48 11.54 TNF IL6 IL1B
49 11.5 TNF IL6 IL1B IL10
50 11.45 TNF TLR4 IL6 IL1B IL10

GO Terms for Urethritis

Cellular components related to Urethritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 TNF KLK3 IL6 IL1B IL10 EPPIN
2 cell surface GO:0009986 9.63 TNF TLR4 TLR2 HSPD1 EPPIN CD4
3 membrane raft GO:0045121 9.62 TNF TLR2 HSPD1 CD4
4 extracellular space GO:0005615 9.36 TNF KLK3 IL6 IL1B IL10 HSPD1
5 lipopolysaccharide receptor complex GO:0046696 9.26 TLR4 HSPD1

Biological processes related to Urethritis according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 10.1 TLR2 IL6 IL1B IL10 CXCL8
2 positive regulation of gene expression GO:0010628 10.09 TNF TLR4 TLR2 IL6 IL1B CXCL8
3 cytokine-mediated signaling pathway GO:0019221 10.03 TNF IL6 IL1B IL10 CXCL8 CD4
4 defense response to bacterium GO:0042742 10 TNF TLR4 IL10 EPPIN DEFB4A DEFA5
5 response to lipopolysaccharide GO:0032496 9.99 TLR4 TLR2 IL1B IL10 HSPD1
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.98 TNF TLR4 TLR2 IL6 IL1B
7 inflammatory response GO:0006954 9.98 TNF TLR4 TLR2 IL6 IL1B CXCL8
8 defense response GO:0006952 9.97 TNF DEFB4A DEFA5 CXCL8
9 positive regulation of DNA-binding transcription factor activity GO:0051091 9.95 TNF IL6 IL1B IL10
10 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.91 TNF TLR4 TLR2 IL1B
11 response to glucocorticoid GO:0051384 9.91 TNF IL6 IL10 HSPD1
12 positive regulation of JNK cascade GO:0046330 9.9 TNF TLR4 IL1B
13 positive regulation of interferon-gamma production GO:0032729 9.9 TNF TLR4 IL1B HSPD1
14 regulation of insulin secretion GO:0050796 9.89 TNF IL6 IL1B
15 negative regulation of interleukin-6 production GO:0032715 9.88 TNF TLR4 IL10
16 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.88 DEFB4A DEFA5 CXCL8
17 positive regulation of T cell proliferation GO:0042102 9.87 IL6 IL1B CD4
18 antimicrobial humoral response GO:0019730 9.87 EPPIN DEFB4A DEFA5
19 positive regulation of interleukin-1 beta production GO:0032731 9.87 TNF TLR4 IL6
20 response to activity GO:0014823 9.86 IL6 IL10 HSPD1
21 T cell activation GO:0042110 9.85 HSPD1 CD8A CD4
22 positive regulation of nitric oxide biosynthetic process GO:0045429 9.85 TNF TLR4 IL1B
23 positive regulation of interleukin-12 production GO:0032735 9.84 TLR4 TLR2 HSPD1
24 positive regulation of JAK-STAT cascade GO:0046427 9.83 TNF IL6 IL10
25 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.83 TLR4 TLR2 HSPD1
26 negative regulation of neurogenesis GO:0050768 9.81 TNF IL6 IL1B
27 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.81 TNF TLR4 IL6
28 positive regulation of chemokine production GO:0032722 9.81 TNF TLR4 TLR2 IL6
29 positive regulation of macrophage activation GO:0043032 9.8 TLR4 IL10 HSPD1
30 positive regulation of glial cell proliferation GO:0060252 9.8 TNF IL6 IL1B
31 positive regulation of inflammatory response GO:0050729 9.8 TNF TLR4 TLR2 IL1B HSPD1
32 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.79 TNF IL1B IL10
33 positive regulation of interleukin-10 production GO:0032733 9.78 TLR4 TLR2 IL6 HSPD1
34 defense response to Gram-negative bacterium GO:0050829 9.77 TLR4 IL6 DEFB4A DEFA5 CD4
35 lipopolysaccharide-mediated signaling pathway GO:0031663 9.76 TNF TLR4 TLR2 IL1B
36 positive regulation of neuroinflammatory response GO:0150078 9.75 TNF IL6 IL1B
37 response to molecule of bacterial origin GO:0002237 9.74 TLR2 IL10 CXCL8
38 defense response to Gram-positive bacterium GO:0050830 9.73 TNF TLR2 IL6 DEFB4A DEFA5 CRP
39 positive regulation of MHC class II biosynthetic process GO:0045348 9.72 TLR4 IL10
40 methionine biosynthetic process GO:0009086 9.72 MTRR MTR
41 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.72 TNF TLR4
42 positive regulation of interleukin-8 production GO:0032757 9.72 TNF TLR4 TLR2 IL6 IL1B
43 regulation of establishment of endothelial barrier GO:1903140 9.71 TNF IL1B
44 cellular response to lipoteichoic acid GO:0071223 9.71 TLR4 TLR2
45 negative regulation of lipid storage GO:0010888 9.71 TNF IL6 CRP
46 endothelial cell apoptotic process GO:0072577 9.7 TNF IL10
47 negative regulation of cytokine production involved in immune response GO:0002719 9.69 TNF IL10
48 sulfur amino acid metabolic process GO:0000096 9.69 MTRR MTR
49 positive regulation of fever generation GO:0031622 9.68 TNF IL1B
50 sequestering of triglyceride GO:0030730 9.67 TNF IL1B

Molecular functions related to Urethritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.13 TNF TLR4 TLR2 MTRR MTR MRAP
2 lipopolysaccharide receptor activity GO:0001875 9.26 TLR4 TLR2
3 lipopolysaccharide binding GO:0001530 9.13 TLR4 TLR2 HSPD1
4 cytokine activity GO:0005125 9.02 TNF IL6 IL1B IL10 CXCL8

Sources for Urethritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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