MCID: URT001
MIFTS: 43

Urethritis

Categories: Nephrological diseases

Aliases & Classifications for Urethritis

MalaCards integrated aliases for Urethritis:

Name: Urethritis 12 44 15 73
Non-Gonococcal Urethritis 12 73
Nongonococcal Urethritis 12 55
Nonspecific Urethritis 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1343
ICD10 33 N34.2 N37.0
ICD9CM 35 597.80
MeSH 44 D014526
NCIt 50 C26904

Summaries for Urethritis

MalaCards based summary : Urethritis, also known as non-gonococcal urethritis, is related to urethral syndrome and reactive arthritis. An important gene associated with Urethritis is DEFB4A (Defensin Beta 4A), and among its related pathways/superpathways is Primary immunodeficiency. The drugs Azithromycin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include prostate, testes and kidney.

Wikipedia : 76 Urethritis is inflammation of the urethra. The most common symptom is painful or difficult urination. It... more...

Related Diseases for Urethritis

Diseases related to Urethritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 439)
# Related Disease Score Top Affiliating Genes
1 urethral syndrome 32.4 CD40LG CD79A MRAP MT-TG PHB2
2 reactive arthritis 31.9 CD79A HSPD1
3 cervicitis 31.1 CD79A DEFB4A HSPD1 MRAP MT-TG
4 balanitis 31.0 MRAP PHB2
5 chlamydia 30.8 CD40LG CD79A HSPD1
6 rhinosporidiosis 30.5 CD40LG CD79A
7 bacteriuria 30.1 CD40LG CD79A
8 pleuropneumonia 30.0 CD40LG CD79A
9 ophthalmia neonatorum 29.9 CD40LG CD79A
10 inclusion conjunctivitis 29.7 CD40LG CD79A
11 pyelitis 29.7 CD40LG CD79A
12 primary syphilis 29.6 CD40LG EXTL3
13 trichomoniasis 29.5 CD79A EXTL3
14 pelvic inflammatory disease 29.4 CD40LG HSPD1 TLR6
15 syphilis 28.9 CD40LG CD79A EXTL3
16 urethral stricture 12.4
17 posterior urethral valves 12.4
18 urethral diverticulum 12.3
19 urethral cancer 12.2
20 urethral benign neoplasm 12.0
21 urethral calculus 12.0
22 urethral obstruction sequence 12.0
23 female urethral cancer 12.0
24 cervical ribs, sprengel anomaly, anal atresia, and urethral obstruction 12.0
25 urethral gland abscess 12.0
26 male urethral cancer 11.9
27 urethral false passage 11.9
28 anterior urethral valve 11.9
29 urethral intrinsic sphincter deficiency 11.8
30 urethral urothelial papilloma 11.8
31 urethral verrucous carcinoma 11.8
32 urethral villous adenoma 11.8
33 vitiligo, progressive, with mental retardation and urethral duplication 11.7
34 infective urethral stricture 11.7
35 prostatic urethral cancer 11.7
36 penile urethral cancer 11.7
37 bulbomembranous urethral cancer 11.7
38 duplication of urethra 11.6
39 hypospadias 11.5
40 exstrophy of bladder 11.4
41 atresia of urethra 11.3
42 urethra squamous cell carcinoma 11.2
43 urethra transitional cell carcinoma 11.2
44 hypospadias 1, x-linked 11.1
45 vacterl association, x-linked, with or without hydrocephalus 11.0
46 congenital anomalies of kidney and urinary tract 1 11.0
47 proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome 10.9
48 posterior urethra cancer 10.9
49 anterior urethra cancer 10.9
50 congenital anomalies of kidney and urinary tract 2 10.8

Comorbidity relations with Urethritis via Phenotypic Disease Network (PDN):


Acute Cystitis Bladder Neck Obstruction
Cystitis Prostate Cancer
Prostatic Hypertrophy Trigonitis
Urethral Stricture

Graphical network of the top 20 diseases related to Urethritis:



Diseases related to Urethritis

Symptoms & Phenotypes for Urethritis

Drugs & Therapeutics for Urethritis

Drugs for Urethritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 55185 447043
2
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 564-25-0 54671203
3
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
4
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
5 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
6 Antibiotics, Antitubercular Phase 4,Phase 3
7 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
8 Antimalarials Phase 4,Phase 3,Phase 2,Not Applicable
9 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable
10 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable
11
Tinidazole Approved, Investigational Phase 2 19387-91-8 5479
12 Alkylating Agents Phase 2
13 Renal Agents Phase 2,Not Applicable
14 Amdinocillin Pivoxil Phase 2
15
Ceftriaxone Approved 73384-59-5 5479530 5361919
16
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
17
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
18
Sulfamethoxazole Approved Not Applicable 723-46-6 5329
19
Trimethoprim Approved, Vet_approved Not Applicable 738-70-5 5578
20 Orange Approved, Nutraceutical Not Applicable
21
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
22
leucovorin Approved, Nutraceutical Not Applicable 58-05-9 143 6006
23 Angiotensin-Converting Enzyme Inhibitors Not Applicable
24 Antiemetics Not Applicable
25 Anti-Inflammatory Agents Not Applicable
26 Antineoplastic Agents, Hormonal Not Applicable
27 Autonomic Agents Not Applicable
28 Cytochrome P-450 Enzyme Inhibitors Not Applicable
29 Folic Acid Antagonists Not Applicable
30 Gastrointestinal Agents Not Applicable
31 glucocorticoids Not Applicable
32 HIV Protease Inhibitors Not Applicable
33 Hormone Antagonists Not Applicable
34 Hormones Not Applicable
35 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
36 Immunoglobulin A Not Applicable
37 Methylprednisolone acetate Not Applicable
38 Methylprednisolone Hemisuccinate Not Applicable
39 Neuroprotective Agents Not Applicable
40 Peripheral Nervous System Agents Not Applicable
41 Prednisolone acetate Not Applicable
42 Prednisolone hemisuccinate Not Applicable
43 Prednisolone phosphate Not Applicable
44
protease inhibitors Not Applicable
45 Protective Agents Not Applicable
46 Vitamin B Complex Not Applicable
47 Anesthetics Not Applicable
48 Folate Nutraceutical Not Applicable
49 Vitamin B9 Nutraceutical Not Applicable
50 Tea Nutraceutical Not Applicable

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
2 Mycoplasma Genitalium Antibiotic Susceptibility and Treatment (MEGA) Completed NCT00358462 Phase 3 Azithromycin;Doxycycline
3 NGU: Doxycycline (Plus or Minus Tinidazole) Versus Azithromycin (Plus or Minus Tinidazole) Completed NCT00322465 Phase 2 Tinidazole;Doxycycline;Azithromycin
4 Study to Improve Partner Services for STD Prevention Completed NCT00207467 Phase 2
5 A Web-based Intervention Study to Reduce High-risk Sexual Behavior by Persons Living With HIV AIDS (PLWH) Completed NCT01198418 Phase 1, Phase 2
6 Safety, Tolerability, and Efficacy of Etrasimod (APD334) in Patients With Primary Biliary Cholangitis Recruiting NCT03155932 Phase 2 APD334
7 Mecillinam for Treatment of Genital Chlamydia Infection Terminated NCT02083276 Phase 2 Pivmecillinamhydrochlorid
8 Trial to Assess the Efficacy of F598 in Preventing an Experimental Urethral Infection With N. Gonorrhoeae in Healthy Males Terminated NCT03222401 Phase 2 1 mg/kg single infusion of F598;3 mg/kg single infusion of F598;10 mg/kg single infusion of F598
9 Accuracy of Detection Using ENdocuff Optimisation of Mucosal Abnormalities Unknown status NCT02552017 Not Applicable
10 Chronic Inflammatory Condition of the Male Genital Tract Completed NCT01732172 Not Applicable
11 Antimicrobial Susceptibility Patterns of N. Gonorrhea Isolates in an Era of Quinolone Resistance Completed NCT00692822
12 Chlamydia Trachomatis Immunology and Vaccinology Study Completed NCT01150747 ceftriaxone;Azithromycin
13 Therapeutic Evaluation of Steroids in IgA Nephropathy Global Study (TESTING Low Dose Study) Recruiting NCT01560052 Not Applicable methylprednisolone;Placebo
14 A Multicenter, Multinational, Observational Morquio A Registry Study (MARS) Recruiting NCT02294877 Vimizim® (elosulfase alfa)
15 Effects of Transcutaneous Acupoint Electrical Stimulation on Intestinal Obstruction After Gastrointestinal Surgery Not yet recruiting NCT03086304 Not Applicable
16 Combined Spinal Epidural Urinary Retention Terminated NCT01597791 Not Applicable

Search NIH Clinical Center for Urethritis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: urethritis

Genetic Tests for Urethritis

Anatomical Context for Urethritis

MalaCards organs/tissues related to Urethritis:

41
Prostate, Testes, Kidney, Skin, Spinal Cord, Colon, Pancreas

Publications for Urethritis

Articles related to Urethritis:

(show top 50) (show all 3055)
# Title Authors Year
1
Evaluation of the Microbiological Efficacy of a Single 2-Gram Dose of Extended-Release Azithromycin by Population Pharmacokinetics and Simulation in Japanese Patients with Gonococcal Urethritis. ( 29038284 )
2018
2
Refractory Urethral Stricture Management: Indications for Alternative Grafts and Flaps. ( 29479650 )
2018
3
A case of spontaneous urinary bladder rupture secondary to urinary retention due to an urethral stricture. ( 29541588 )
2018
4
Defining the Urethritis Syndrome in Men Using Patient Reported Symptoms. ( 29465655 )
2018
5
Optimizing the Role of Surgery and Radiotherapy in Urethral Cancer Based on Histology and Disease Extent. ( 29908944 )
2018
6
Editorial Comment to Width proportion of the urethral plate to the glans can serve as an appraisal index of the urethral plate in hypospadias repair. ( 29862578 )
2018
7
Asymptomatic urethral lymphogranuloma venereum: a case report. ( 29350113 )
2018
8
<i>Candida glabrata</i>: A Unique Cause of Necrotizing Urethritis. ( 29971173 )
2018
9
Combined prostatic urethral lift and remodeling of the prostate and bladder neck: a modified transurethral approach in the treatment of symptomatic lower urinary tract obstruction. ( 29450732 )
2018
10
Posterior urethral valves: 10 years audit of epidemiologic, diagnostic and therapeutic aspects in YaoundAc gynaeco-obstetric and paediatric hospital. ( 29783971 )
2018
11
Management of long segment anterior urethral stricture (a8Y 8cm) using buccal mucosal (BM) graft and penile skin (PS) flap: outcome and predictors of failure. ( 29211404 )
2018
12
Urethral mobility and Point Aa of the Pelvic Organ Prolapse Quantification (POP-Q) system before and after midurethral sling operation. ( 29938931 )
2018
13
Endoscopic Management of Urethral Stricture: Review and Practice Algorithm for Management of Male Urethral Stricture Disease. ( 29479640 )
2018
14
All grown up: A transitional care perspective on the patient with posterior urethral valves. ( 29681268 )
2018
15
Female urethral diverticulum containing large calculi. ( 29686963 )
2018
16
Isotretinoin-induced urethritis versus non-gonococcal urethritis in a man who has sex with men: an open debate. ( 29512421 )
2018
17
Re: Repair of pan-urethral stricture: Proximal ventral and distal dorsal onlay technique of buccal mucosal graft urethroplasty. By Subbarao Chodisetti, Yogesh Boddepalli, Malakondareddy Kota. ( 29892485 )
2018
18
A novel heterozygous GLI2 mutation in a patient with congenital urethral stricture and renal hypoplasia/dysplasia leading to end-stage renal failure. ( 29318530 )
2018
19
Re: Urethral Stricture Outcomes after Artificial Urinary Sphincter Cuff Erosion: Results from a Multicenter Retrospective Analysis. ( 29357550 )
2018
20
Re: Low Testosterone Levels Result in Decreased Periurethral Vascularity via an Androgen Receptor-Mediated Process: Pilot Study in Urethral Stricture Tissue. ( 29357549 )
2018
21
Surgical correction of urethral diverticulum in a female pseudo-hermaphrodite crossbred calf. ( 29805465 )
2018
22
Hypoandrogenism is Prevalent in Males with Urethral Stricture Disease and is Associated with Longer Strictures. ( 29378279 )
2018
23
Lichen Sclerosus Accompanied by Urethral Squamous Cell Carcinoma: A Retrospective Study From a Urethral Referral Center. ( 29926751 )
2018
24
Expansion of a urethritis-associated Neisseria meningitidis clade in the United States with concurrent acquisition of N. gonorrhoeae alleles. ( 29499642 )
2018
25
Urethral lichen sclerosus under the microscope: a survey of academic pathologists. ( 29900821 )
2018
26
Long term follow up of proximal hypospadias repair-urethral stricture should be excluded in adults who present with epididymo-orchitis. ( 29511587 )
2018
27
Suspected congenital urethral diverticulum in a dog. ( 29599553 )
2018
28
Long-term Effect of Colchicine Treatment in Preventing Urethral Stricture Recurrence After Internal Urethrotomy. ( 29681046 )
2018
29
GyrA and/or ParC alterations of Haemophilus influenzae strains isolated from the urethra of men with acute urethritis. ( 29138021 )
2018
30
Predicting and Modifying Risk for Development of Renal Failure in Boys with Posterior Urethral Valves. ( 29774481 )
2018
31
Novel Treatment Setup for Urethral Cancer: Use of the Prone Technique for Radiotherapy of the Penis. ( 29867434 )
2018
32
microRNA expression profiles of scar and normal tissue from patients with posterior urethral stricture caused by pelvic fracture urethral distraction defects. ( 29436608 )
2018
33
Neisseria meningitidis urethritis: synthesis of published data. ( 29797510 )
2018
34
Penoscrotal Transposition to Achieve Urethral Continuity After Long-Segment Urethral Defect: A Case Report. ( 29737937 )
2018
35
An Experimental Model of Anterior Urethral Stricture in Rabbits With Local Injections of Bleomycin. ( 29545036 )
2018
36
The protective arm of the renin-angiotensin system may counteract the intense inflammatory process in fetuses with posterior urethral valves. ( 29534877 )
2018
37
Ejaculatory Disorders in Men With Urethral Stricture and Impact of Urethroplasty on the Ejaculatory Function: A Systematic Review. ( 29960631 )
2018
38
Incidental Finding of Urethral Diverticulum in a Woman with History of Recurrent Urinary Tract Infections. ( 29692697 )
2018
39
Management of posterior urethral valves in fetuses and neonates: a critical point of view. ( 29795074 )
2018
40
Muscle-invasive bladder and urethral cancer recurrence after surgical management of upper tract urothelial carcinoma: A review of 305 patients. ( 29733795 )
2018
41
Giant Urethral Calculus without Acute Urinary Retention. ( 29482714 )
2018
42
Prevalence of Mycoplasma genitalium in men with urethritis in a large public hospital in Brussels, Belgium: An observational, cross-sectional study. ( 29698421 )
2018
43
Prevalence of asymptomatic urethritis by Chlamydia trachomatis and Neisseria gonorrhoeae and associated risk factors among males living with HIV-1. ( 29538508 )
2018
44
A Simplified Adult Acquired Buried Penis Repair Classification System with an Analysis of Perioperative Complications and Urethral Stricture Disease<sup>,,a9^a9^a9^</sup>. ( 29898381 )
2018
45
Neisseria gonorrhoeae DNA bacterial load in men with symptomatic and asymptomatic gonococcal urethritis. ( 28148678 )
2017
46
Predicting postnatal renal function of prenatally detected posterior urethral valves using fetal diffusion-weighted magnetic resonance imaging with apparent diffusion coefficient determination. ( 28453880 )
2017
47
Quantitative Real-Time Polymerase Chain Reaction for the Diagnosis of Mycoplasma genitalium Infection in South African Men With and Without Symptoms of Urethritis. ( 27898565 )
2017
48
Role of urethral plate and fossa navicularis biopsies in the detection of balanitis xerotica obliterans in boys undergoing redo hypospadias repair. ( 29234536 )
2017
49
Large Cluster of Neisseria Meningitidis Urethritis in Columbus, Ohio, 2015. ( 28481980 )
2017
50
Diagnosis of urethral diverticulum mimicking pelvic organ prolapse with translabial ultrasonography. ( 28666694 )
2017

Variations for Urethritis

Expression for Urethritis

Search GEO for disease gene expression data for Urethritis.

Pathways for Urethritis

Pathways related to Urethritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.19 CD40LG CD79A

GO Terms for Urethritis

Biological processes related to Urethritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.37 HSPD1 TLR6
2 B cell activation GO:0042113 9.32 CD79A HSPD1
3 positive regulation of interleukin-12 production GO:0032735 9.26 CD40LG HSPD1
4 positive regulation of interleukin-10 production GO:0032733 9.16 CD40LG HSPD1
5 positive regulation of macrophage activation GO:0043032 8.96 HSPD1 TLR6
6 B cell proliferation GO:0042100 8.8 CD40LG CD79A HSPD1

Sources for Urethritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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