MCID: URN001
MIFTS: 28

Urinary Bladder Small Cell Neuroendocrine Carcinoma

Categories: Cancer diseases, Nephrological diseases, Neuronal diseases

Aliases & Classifications for Urinary Bladder Small Cell Neuroendocrine Carcinoma

MalaCards integrated aliases for Urinary Bladder Small Cell Neuroendocrine Carcinoma:

Name: Urinary Bladder Small Cell Neuroendocrine Carcinoma 12 15
Small Cell Neuroendocrine Carcinoma of the Urinary Bladder 12
Small Cell/neuroendocrine Carcinoma of Urinary Bladder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7132
NCIt 51 C9461
UMLS 74 C1332564

Summaries for Urinary Bladder Small Cell Neuroendocrine Carcinoma

MalaCards based summary : Urinary Bladder Small Cell Neuroendocrine Carcinoma, also known as small cell neuroendocrine carcinoma of the urinary bladder, is related to adrenocortical carcinoma, hereditary and neuroendocrine carcinoma. An important gene associated with Urinary Bladder Small Cell Neuroendocrine Carcinoma is SYP (Synaptophysin). The drugs nivolumab and Ipilimumab have been mentioned in the context of this disorder. Affiliated tissues include prostate, brain and bone.

Related Diseases for Urinary Bladder Small Cell Neuroendocrine Carcinoma

Diseases related to Urinary Bladder Small Cell Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 151)
# Related Disease Score Top Affiliating Genes
1 adrenocortical carcinoma, hereditary 10.1 CHGA SYP
2 neuroendocrine carcinoma 10.1
3 ureter small cell carcinoma 10.1 CHGA SYP
4 esophageal neuroendocrine tumor 10.1 CHGA SYP
5 ovarian large-cell neuroendocrine carcinoma 10.1 CHGA SYP
6 acinar cell cystadenocarcinoma 10.1 CHGA SYP
7 peritoneal serous adenocarcinoma 10.1 CHGA SYP
8 cellular ependymoma 10.1 CHGA SYP
9 primary hepatic neuroendocrine carcinoma 10.1 CHGA SYP
10 gastrointestinal neuroendocrine tumor 10.1 CHGA SYP
11 chordoid meningioma 10.1 CHGA SYP
12 olfactory groove meningioma 10.1 CHGA SYP
13 pancreatic serous cystadenoma 10.1 CHGA SYP
14 cystadenoma 10.1 CHGA SYP
15 conventional angiosarcoma 10.1 CHGA SYP
16 pulmonary sclerosing hemangioma 10.1 CHGA SYP
17 sclerosing hemangioma 10.1 CHGA SYP
18 pancreatoblastoma 10.1 CHGA SYP
19 anterior cranial fossa meningioma 10.0 CHGA SYP
20 pulmonary blastoma 10.0 CHGA SYP
21 pleomorphic xanthoastrocytoma 10.0 CHGA SYP
22 tanycytic ependymoma 10.0 CHGA SYP
23 non-functioning pancreatic endocrine tumor 10.0 CHGA SYP
24 binswanger's disease 10.0 CHGA SYP
25 gastric tubular adenocarcinoma 10.0 CHGA SYP
26 tubular adenocarcinoma 10.0 CHGA SYP
27 hydrocephalus 10.0 ENO2 SYP
28 oligodendroglioma 10.0 ENO2 SYP
29 nervous system disease 10.0 ENO2 SYP
30 ganglioneuroblastoma 10.0 ENO2 SYP
31 ependymoma 10.0 ENO2 SYP
32 endocrine organ benign neoplasm 10.0 CHGA SYP
33 carotid body cancer 10.0 ENO2 SYP
34 malignant sertoli cell tumor 10.0 ENO2 SYP
35 lung meningioma 10.0 ENO2 GRP
36 sinonasal undifferentiated carcinoma 10.0 ENO2 SYP
37 pancreatic somatostatinoma 10.0 ENO2 SYP
38 primary pigmented nodular adrenocortical disease 10.0 CHGA SYP
39 cutaneous ganglioneuroma 10.0 ENO2 SYP
40 extrahepatic bile duct adenocarcinoma 10.0 ENO2 SYP
41 papillary tumor of the pineal region 10.0 ENO2 SYP
42 sensory organ benign neoplasm 10.0 ENO2 SYP
43 orbital cancer 10.0 ENO2 SYP
44 middle ear adenoma 10.0 ENO2 SYP
45 central nervous system primitive neuroectodermal neoplasm 10.0 ENO2 SYP
46 cerebellum cancer 10.0 ENO2 SYP
47 clear cell ependymoma 10.0 ENO2 SYP
48 cerebral neuroblastoma 10.0 ENO2 SYP
49 endometrial small cell carcinoma 10.0 ENO2 SYP
50 extraosseous chondrosarcoma 10.0 ENO2 SYP

Graphical network of the top 20 diseases related to Urinary Bladder Small Cell Neuroendocrine Carcinoma:



Diseases related to Urinary Bladder Small Cell Neuroendocrine Carcinoma

Symptoms & Phenotypes for Urinary Bladder Small Cell Neuroendocrine Carcinoma

Drugs & Therapeutics for Urinary Bladder Small Cell Neuroendocrine Carcinoma

Drugs for Urinary Bladder Small Cell Neuroendocrine Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2
Ipilimumab Approved Phase 2 477202-00-9
3 Antineoplastic Agents, Immunological Phase 2,Phase 1
4 Immunoglobulins Phase 2
5 Antibodies, Monoclonal Phase 2
6 Antibodies Phase 2
7
Docetaxel Approved, Investigational Phase 1 114977-28-5 148124
8
Cisplatin Approved Phase 1 15663-27-1 441203 84093 2767
9
Etoposide Approved Phase 1 33419-42-0 36462
10
Carboplatin Approved Phase 1 41575-94-4 38904 10339178 498142
11
Pembrolizumab Approved Phase 1 1374853-91-4
12 Dermatologic Agents Phase 1
13 Antineoplastic Agents, Phytogenic Phase 1
14 Podophyllotoxin Phase 1 518-28-5
15 Topoisomerase Inhibitors Phase 1
16 Antimitotic Agents Phase 1
17 Keratolytic Agents Phase 1
18 Etoposide phosphate Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cabozantinib S-Malate, Nivolumab, and Ipilimumab in Treating Patients With Metastatic Genitourinary Tumors Not yet recruiting NCT03866382 Phase 2 Cabozantinib;Cabozantinib S-malate
2 Pembrolizumab With Combination Chemotherapy in Treating Participants With Locally Advanced or Metastatic Small Cell/Neuroendocrine Cancers of Urothelium or Prostate Recruiting NCT03582475 Phase 1 Carboplatin;Cisplatin;Docetaxel;Etoposide

Search NIH Clinical Center for Urinary Bladder Small Cell Neuroendocrine Carcinoma

Genetic Tests for Urinary Bladder Small Cell Neuroendocrine Carcinoma

Anatomical Context for Urinary Bladder Small Cell Neuroendocrine Carcinoma

MalaCards organs/tissues related to Urinary Bladder Small Cell Neuroendocrine Carcinoma:

42
Prostate, Brain, Bone, Bone Marrow

Publications for Urinary Bladder Small Cell Neuroendocrine Carcinoma

Articles related to Urinary Bladder Small Cell Neuroendocrine Carcinoma:

(show all 12)
# Title Authors Year
1
Primary small-cell neuroendocrine carcinoma of the urinary bladder: A rare case and a review of the literature. ( 30155256 )
2018
2
A rare case of small cell neuroendocrine carcinoma of the urinary bladder incidentally detected by F-18-FDG PET/CT. ( 23783367 )
2013
3
Small cell neuroendocrine carcinoma of the urinary bladder: report on two cases and review of the literature. ( 20549899 )
2010
4
Primary small cell neuroendocrine carcinoma of the urinary bladder: a clinicopathologic, immunohistochemical, and ultrastructural evaluation. ( 20594044 )
2010
5
Primary small cell neuroendocrine carcinoma of the urinary bladder with coexisting high-grade urothelial carcinoma: a case report and a review of the literature. ( 16269089 )
2005
6
Magnetic resonance imaging of bone marrow metastasis with fluid-fluid levels from small cell neuroendocrine carcinoma of the urinary bladder. ( 12477566 )
2002
7
Brain metastasis from small-cell neuroendocrine carcinoma of the urinary bladder: a case report. ( 12622144 )
2002
8
Small cell neuroendocrine carcinoma of the urinary bladder: case report of a rare primary tumor. ( 11471463 )
2001
9
Small cell neuroendocrine carcinoma of the urinary bladder. A clinicopathologic study with emphasis on cytologic features. ( 9010109 )
1997
10
Undifferentiated small cell neuroendocrine carcinoma of the urinary bladder. ( 1326303 )
1992
11
Small cell neuroendocrine carcinoma of the urinary bladder. An immunohistochemical and ultrastructural evaluation of 3 cases with a review of the literature. ( 2849230 )
1988
12
Small cell neuroendocrine carcinoma of the urinary bladder: report of three cases with ultrastructural analysis. ( 6308862 )
1983

Variations for Urinary Bladder Small Cell Neuroendocrine Carcinoma

Expression for Urinary Bladder Small Cell Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Urinary Bladder Small Cell Neuroendocrine Carcinoma.

Pathways for Urinary Bladder Small Cell Neuroendocrine Carcinoma

GO Terms for Urinary Bladder Small Cell Neuroendocrine Carcinoma

Cellular components related to Urinary Bladder Small Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasmic vesicle GO:0031410 8.8 CHGA GRP SYP

Biological processes related to Urinary Bladder Small Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway GO:1900738 8.62 CHGA GRP

Sources for Urinary Bladder Small Cell Neuroendocrine Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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