MCID: URN003
MIFTS: 50

Urinary Schistosomiasis

Categories: Blood diseases, Infectious diseases, Nephrological diseases

Aliases & Classifications for Urinary Schistosomiasis

MalaCards integrated aliases for Urinary Schistosomiasis:

Name: Urinary Schistosomiasis 12 15 73
Schistosoma Hematobium Infection 12 73
Schistosomiasis Due to Schistosoma Haematobium 12
Schistosoma Hematobium Infectious Disease 12
Schistosoma Haematobium Infection 12
Cystitis with Bilharziasis 12
Schistosomiasis of Bladder 12
Schistosomiasis Haematobia 44
Bladder Schistosomiasis 12
Schistosoma Haematobium 12
Vesical Schistosomiasis 12
Schistosomiasis Urinary 55

Classifications:



External Ids:

Disease Ontology 12 DOID:1394
ICD9CM 35 120.0
MeSH 44 D012553
SNOMED-CT 68 53991003 60979006

Summaries for Urinary Schistosomiasis

Disease Ontology : 12 A schistosomiasis that involves parasitic infection of the urinary tract caused by a digenetic trematode Schistosoma haematobium causing cystitis, ureteritis, fibrosis of the bladder and haematuria, which can progress to bladder cancer.

MalaCards based summary : Urinary Schistosomiasis, also known as schistosoma hematobium infection, is related to schistosomiasis and buruli ulcer. An important gene associated with Urinary Schistosomiasis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Lumefantrine and Albendazole have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and lung, and related phenotypes are hematopoietic system and immune system

Related Diseases for Urinary Schistosomiasis

Diseases related to Urinary Schistosomiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 193)
# Related Disease Score Top Affiliating Genes
1 schistosomiasis 31.5 IFNG IL13 IL4 IL5 RNASE3 STAT6
2 buruli ulcer 30.4 IFNG IL4
3 parasitic helminthiasis infectious disease 30.1 IL13 IL4 IL5 RNASE3
4 intestinal schistosomiasis 29.8 IL13 IL4 IL5 STAT6
5 onchocerciasis 29.5 EPX IL13 IL4 IL5 RNASE3
6 malaria 29.5 CTLA4 HP IFNG IL13 IL4 IL5
7 neuroschistosomiasis 11.7
8 plasmodium falciparum malaria 10.3
9 urinary tract obstruction 10.3
10 splenomegaly 10.3
11 schistosoma mansoni infection, susceptibility/ 10.3
12 loeffler endocarditis 10.2 IL5 RNASE3
13 cow milk allergy 10.2 IL5 RNASE3
14 blepharoconjunctivitis 10.2 IL4 RNASE3
15 giant papillary conjunctivitis 10.2 IL4 RNASE3
16 status asthmaticus 10.2 IL5 RNASE3
17 chronic eosinophilic pneumonia 10.2 IL5 RNASE3
18 eosinophilic fasciitis 10.2 IFNG IL5
19 cephalosporin allergy 10.2 IFNG IL5
20 egg allergy 10.2 IL4 IL5
21 sulfamethoxazole allergy 10.2 IL4 IL5
22 gaucher disease, type ii 10.2 IL4 IL5
23 trichinosis 10.2 IL4 IL5
24 sinusitis 10.2 IL5 RNASE3
25 non-suppurative otitis media 10.2 IL4 IL5
26 filarial elephantiasis 10.2 IL4 IL5
27 hyperlucent lung 10.2 IFNG IL4
28 autoimmune myocarditis 10.2 IFNG IL4
29 b-cell growth factor 10.2 IFNG IL4
30 cardiac sarcoidosis 10.2 IFNG IL5
31 eosinophilia-myalgia syndrome 10.2 IFNG IL5
32 baylisascariasis 10.2 IFNG IL4
33 crustacean allergy 10.2 IFNG IL4
34 cytokine deficiency 10.2 IL13 IL5
35 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL13 IL5
36 wells syndrome 10.2 IL5 RNASE3
37 trichuriasis 10.2 IL13 RNASE3
38 respiratory syncytial virus infectious disease 10.2 IL13 IL5
39 hypersplenism 10.2 IFNG IL4
40 churg-strauss syndrome 10.2 IL5 RNASE3
41 hyper ige syndrome 10.2 IFNG IL4
42 orofacial granulomatosis 10.2 IFNG IL4
43 primary systemic mycosis 10.2 IFNG IL4
44 poliomyelitis 10.2 IFNG IL4
45 eales disease 10.2 IFNG IL4
46 lichen disease 10.2 IFNG IL4
47 african tick-bite fever 10.2 IFNG IL13
48 coccidiosis 10.2 IFNG IL4
49 cryptococcosis 10.2 IFNG IL4
50 ocular cicatricial pemphigoid 10.1 IL4 RNASE3

Graphical network of the top 20 diseases related to Urinary Schistosomiasis:



Diseases related to Urinary Schistosomiasis

Symptoms & Phenotypes for Urinary Schistosomiasis

MGI Mouse Phenotypes related to Urinary Schistosomiasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.86 CTLA4 EPX HP IFNG IL13 IL4
2 immune system MP:0005387 9.76 CTLA4 EPX HP IFNG IL13 IL4
3 digestive/alimentary MP:0005381 9.72 CTLA4 IFNG IL13 IL4 IL5
4 liver/biliary system MP:0005370 9.43 CTLA4 HP IFNG IL4 IL5 STAT6
5 respiratory system MP:0005388 9.1 CTLA4 IFNG IL13 IL4 IL5 STAT6

Drugs & Therapeutics for Urinary Schistosomiasis

Drugs for Urinary Schistosomiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lumefantrine Approved Phase 4 82186-77-4 6437380
2
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
3
Artemether Approved Phase 4 71963-77-4 119380 68911
4
Praziquantel Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 55268-74-1 4891
5
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
6 Antiprotozoal Agents Phase 4,Phase 2
7 Anthelmintics Phase 4,Phase 3
8 Antimitotic Agents Phase 4
9 Antiparasitic Agents Phase 4,Phase 3,Phase 2
10 Artemether-lumefantrine combination Phase 4
11 Artemisinine Phase 4
12 Anti-Infective Agents Phase 4,Phase 3,Phase 2
13 Antifungal Agents Phase 4
14 Antimalarials Phase 4,Phase 2
15 Artemisinins Phase 4
16 Immunologic Factors Phase 3,Phase 2,Phase 1
17 Vaccines Phase 3,Phase 2,Phase 1
18
Sulfadoxine Approved, Investigational Phase 2 2447-57-6 17134
19
Mefloquine Approved, Investigational Phase 2 53230-10-7 4046
20
Pyrimethamine Approved, Investigational, Vet_approved Phase 2 58-14-0 4993
21 Fanasil, pyrimethamine drug combination Phase 2
22 Pharmaceutical Solutions Phase 2
23
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
24
Aluminum sulfate Approved Phase 1 10043-01-3
25 Adjuvants, Immunologic Phase 1
26 Antibodies Phase 1
27 Immunoglobulins Phase 1
28 Gastrointestinal Agents Phase 1
29 Anti-Ulcer Agents Phase 1
30 Antacids Phase 1
31
Doxycycline Approved, Investigational, Vet_approved Not Applicable 564-25-0 54671203
32
Cefuroxime Approved Not Applicable 55268-75-2 5361202 5479529
33
Ciprofloxacin Approved, Investigational Not Applicable 85721-33-1 2764
34
Azithromycin Approved Not Applicable 83905-01-5 55185 447043
35
Metronidazole Approved Not Applicable 443-48-1 4173
36 cefuroxime axetil Not Applicable

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Artemisinin-based Combination Therapy-Intermittent Preventive Treatment (ACT-IPT) Trial Among Schoolchildren in Kassena-Nankana, Ghana Unknown status NCT01459146 Phase 4 Artemether-lumefantrine combination plus albendazole;Artemether-lumefantrine plus Praziquantel plus Albendazole;Albendazole plus Praziquantel
2 Efficacy of Bilhvax in Association With Praziquantel for Prevention of Clinical Recurrences of Schistosoma Haematobium Completed NCT00870649 Phase 3
3 Activity of Mefloquine Against Urinary Schistosomiasis Completed NCT01132248 Phase 2 Mefloquine;S/P
4 Study of Safety and Immune Response of the Sm14 Vaccine in Adults of Endemic Regions Completed NCT03041766 Phase 2 GLA-SE solution
5 Anti-Schistosomiasis Vaccine: Sm14 Phase 2b-Sn in School Children Active, not recruiting NCT03799510 Phase 2 GLA-SE solution
6 Clinical Trial of Bilhvax,a Vaccine Candidate Against Schistosomiasis Completed NCT01512277 Phase 1
7 Urogenital Schistosomiasis and Sexually Transmitted Infections in Madagascar Completed NCT00713999 Not Applicable Treatment with anti-STI and anti-schistosoma regimens
8 Urinary Schistosomiasis Infection Completed NCT00138450
9 Childhood Schistosomiasis: a Novel Strategy Extending the Benefits/Reach of Antihelminthic Treatment Completed NCT02495909
10 Health Benefits of Repeated Treatment in Pediatric Schistosomiasis Completed NCT01424410
11 Prevention of Female Genital Schistosomiasis (FGS) in Rural High-endemic South Africa Recruiting NCT01154907 Praziquantel

Search NIH Clinical Center for Urinary Schistosomiasis

Cochrane evidence based reviews: schistosomiasis haematobia

Genetic Tests for Urinary Schistosomiasis

Anatomical Context for Urinary Schistosomiasis

MalaCards organs/tissues related to Urinary Schistosomiasis:

41
Testes, Skin, Lung, Bone, Tonsil, Thyroid, T Cells

Publications for Urinary Schistosomiasis

Articles related to Urinary Schistosomiasis:

(show top 50) (show all 381)
# Title Authors Year
1
Urinary schistosomiasis presented as bladder malignancy with pulmonary metastases: a case report. ( 29962297 )
2018
2
Infection status and risk factors associated with urinary schistosomiasis among school-going children in the Ndumo area of uMkhanyakude District in KwaZulu-Natal, South Africa two years post-treatment. ( 29679769 )
2018
3
Urinary schistosomiasis in migrant population: a case series from a single centre in southern Italy. ( 30377953 )
2018
4
Urinary schistosomiasis: report of case diagnosed in bladder biopsy. ( 30519144 )
2018
5
Safety and efficacy of the rSh28GST urinary schistosomiasis vaccine: a phase 3 randomized, controlled trial in Senegalese children. ( 30532268 )
2018
6
Knowledge, attitudes and practices regarding urinary schistosomiasis among adults in the Ekombe Bonji Health Area, Cameroon. ( 30050625 )
2018
7
Ultrasound Evolution of Pediatric Urinary Schistosomiasis after Treatment with Praziquantel in a Highly Endemic Area. ( 30141396 )
2018
8
Rapid mapping of urinary schistosomiasis: An appraisal of the diagnostic efficacy of some questionnaire-based indices among high school students in Katsina State, northwestern Nigeria. ( 28369090 )
2017
9
A comparative study on the efficacy of praziquantel and albendazole in the treatment of urinary schistosomiasis in Adim, Cross River State, Nigeria. ( 28911129 )
2017
10
Urinary schistosomiasis:<i>Schistosoma haematobium</i>infection diagnosed by histopathology. ( 29323093 )
2017
11
Urinary schistosomiasis in school aged children of two rural endemic communities in Edo State, Nigeria. ( 28970097 )
2017
12
Urinary schistosomiasis in school children of a southern nigerian community 8 years after the provision of potable water. ( 29355157 )
2017
13
Epidemiology of Urinary Schistosomiasis among School Children in the Alsaial Alsagair Village, River Nile State, Sudan. ( 28761490 )
2017
14
Prevalence of Urinary Schistosomiasis in Migrants in Apulia, a Region of Southern Italy, in the Years 2006-2016. ( 29435460 )
2017
15
Urinary schistosomiasis among vulnerable children in a rehabilitation home in Ibadan, Oyo state, Nigeria. ( 28693436 )
2017
16
Using the hierarchical ordinal regression model to analyse the intensity of urinary schistosomiasis infection in school children in Lusaka Province, Zambia. ( 28219411 )
2017
17
Prevalence and intensity of genito-urinary schistosomiasis and associated risk factors among junior high school students in two local government areas around Zobe Dam in Katsina State, Nigeria. ( 27388007 )
2016
18
Circulating cathodic antigen cassette test versus haematuria strip test in diagnosis of urinary schistosomiasis. ( 27876913 )
2016
19
Urinary schistosomiasis among preschool children in Malengachanzi, Nkhotakota District, Malawi: Prevalence and risk factors. ( 27217911 )
2016
20
Incidental pseudolymphomatous bladder inflammatory polyp revealing urinary schistosomiasis. ( 27810520 )
2016
21
Urinary Schistosomiasis among Children in Murbai and Surbai Communities of Ardo-Kola Local Government Area, Taraba State, Nigeria. ( 28096819 )
2016
22
EPIDEMIOLOGICAL SITUATION OF URINARY SCHISTOSOMIASIS IN TAMWAH AREA, GIZA, EGYPT: ASSESSMENT AND CONTROL. ( 30230744 )
2016
23
Environmental factors and the risk of urinary schistosomiasis in Ile Oluji/Oke Igbo local government area of Ondo State. ( 29988176 )
2016
24
Immunolocalization of the 29 kDa Schistosoma haematobium species-specific antigen: a potential diagnostic marker for urinary schistosomiasis. ( 25927905 )
2015
25
Prevalence of urinary schistosomiasis and associated risk factors among Abobo Primary School children in Gambella Regional State, southwestern Ethiopia: a cross sectional study. ( 25886292 )
2015
26
Lectin Complement Protein Collectin 11 (CL-K1) and Susceptibility to Urinary Schistosomiasis. ( 25807310 )
2015
27
Bladder cancer and urinary Schistosomiasis in Angola. ( 26167543 )
2015
28
Salmonella Typhi meningitis in a 9-year old boy with urinary schistosomiasis: a case report. ( 25889776 )
2015
29
Urinary Schistosomiasis in an Adolescent Refugee from Africa: An Uncommon Cause of Hematuria and an Emerging Infectious Disease in Europe. ( 26335551 )
2015
30
High levels of urinary schistosomiasis among children in Bunuso, a rural community in Ghana: an urgent call for increased surveillance and control programs. ( 26688622 )
2015
31
Efficacy of praziquantel against urinary schistosomiasis and reinfection in Senegalese school children where there is a single well-defined transmission period. ( 26156522 )
2015
32
The effect of hookworm infection and urinary schistosomiasis on blood hemoglobin concentration of schoolchildren living in northern Mozambique. ( 24879000 )
2014
33
Prevalence, intensity of infection and risk factors of urinary schistosomiasis in pre-school and school aged children in Guma Local Government Area, Nigeria. ( 24418080 )
2014
34
The unacknowledged impact of urinary schistosomiasis in children: 5 cases from Kumasi, Ghana. ( 25709140 )
2014
35
Drugs for treating urinary schistosomiasis. ( 25099517 )
2014
36
Prevalence and intensity of urinary schistosomiasis among school children in the district of Niakhar, region of Fatick, Senegal. ( 24387599 )
2014
37
Bacteriuria and urinary schistosomiasis in primary school children in rural communities in Enugu State, Nigeria, 2012. ( 25328634 )
2014
38
Urinary schistosomiasis. ( 24469437 )
2014
39
Clinical efficacy and tolerability of praziquantel for intestinal and urinary schistosomiasis-a meta-analysis of comparative and non-comparative clinical trials. ( 25412105 )
2014
40
Urinary schistosomiasis among schoolchildren in Yemen: prevalence, risk factors, and the effect of a chemotherapeutic intervention. ( 24374945 )
2013
41
Spatial distribution of urinary schistosomiasis in Cross River State, Nigeria using geographical information system and school based questionnaire. ( 24506017 )
2013
42
Ultrasound findings in urinary schistosomiasis infection in school children in Gezira State, Central Sudan. ( 24231496 )
2013
43
Urinary schistosomiasis in urban and semi-urban communities in South-eastern Nigeria. ( 24454442 )
2013
44
Urinary schistosomiasis and malaria associated anemia in Ethiopia. ( 23620856 )
2013
45
A rare case of urinary schistosomiasis in Turkey. ( 24280295 )
2013
46
Urinary schistosomiasis in asylum seekers in Italy: an emergency currently undervalued. ( 23135629 )
2013
47
Prevalence of Urinary Schistosomiasis among School Children in a Rural Community in South-South, Nigeria. ( 23913499 )
2013
48
Urinary schistosomiasis: review. ( 25685452 )
2013
49
Immunohistochemical expression of COX2 and iNOS in bladder cancer and its association with urinary schistosomiasis among Sudanese patients. ( 23414519 )
2013
50
The role of artesunate for the treatment of urinary schistosomiasis in schoolchildren: a systematic review and meta-analysis. ( 23265611 )
2012

Variations for Urinary Schistosomiasis

Expression for Urinary Schistosomiasis

Search GEO for disease gene expression data for Urinary Schistosomiasis.

Pathways for Urinary Schistosomiasis

Pathways related to Urinary Schistosomiasis according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.76 CTLA4 EPX HP IFNG IL13 IL4
2
Show member pathways
13.15 IFNG IL13 IL4 IL5 STAT6
3 12.64 IFNG IL13 IL4 IL5 STAT6
4
Show member pathways
12.61 CTLA4 EPX IFNG IL13 IL4 IL5
5
Show member pathways
12.41 IFNG IL13 IL4 IL5 STAT6
6 12.4 CTLA4 IFNG IL4 STAT6
7
Show member pathways
12.28 CTLA4 IFNG IL4 IL5
8
Show member pathways
12.22 IFNG IL13 IL4 IL5 STAT6
9
Show member pathways
12.17 IFNG IL13 IL4 IL5
10
Show member pathways
12.1 IFNG IL13 IL4 IL5
11
Show member pathways
11.91 IFNG IL13 IL4 IL5
12
Show member pathways
11.9 IFNG IL13 IL4
13 11.86 IFNG IL4 IL5
14 11.84 IL13 IL4 STAT6
15
Show member pathways
11.83 IFNG IL4 STAT6
16 11.65 IFNG IL13 IL4 IL5
17 11.61 IFNG IL13 IL4 IL5
18 11.6 IFNG IL13 IL4
19
Show member pathways
11.55 CTLA4 IFNG IL4 IL5
20 11.53 IL4 IL5 STAT6
21 11.52 IL13 IL4 IL5
22 11.19 IFNG IL4 IL5
23 11.08 IFNG IL13
24 11.06 IFNG IL13 IL4 IL5
25 11.03 IL13 IL4 IL5
26 10.92 IFNG IL13 IL4 IL5
27 10.68 IFNG IL13 IL4 IL5 STAT6
28 10.67 IFNG IL13 IL4 IL5

GO Terms for Urinary Schistosomiasis

Cellular components related to Urinary Schistosomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 EPX HP IFNG IL13 IL4 IL5
2 extracellular space GO:0005615 9.17 EPX HP IFNG IL13 IL4 IL5

Biological processes related to Urinary Schistosomiasis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.76 IFNG IL13 IL4 IL5
2 defense response to bacterium GO:0042742 9.67 EPX HP RNASE3
3 cytokine-mediated signaling pathway GO:0019221 9.67 IL13 IL4 IL5 STAT6
4 immune response GO:0006955 9.65 CTLA4 IFNG IL13 IL4 IL5
5 positive regulation of cold-induced thermogenesis GO:0120162 9.58 IL13 IL4 STAT6
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.5 IFNG IL13 IL4
7 negative regulation of endothelial cell apoptotic process GO:2000352 9.48 IL13 IL4
8 regulation of regulatory T cell differentiation GO:0045589 9.43 CTLA4 IFNG
9 negative regulation of complement-dependent cytotoxicity GO:1903660 9.16 IL13 IL4
10 positive regulation of isotype switching to IgE isotypes GO:0048295 8.96 IL4 STAT6
11 positive regulation of B cell proliferation GO:0030890 8.8 IL13 IL4 IL5

Molecular functions related to Urinary Schistosomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 8.96 IL13 IL4
2 cytokine activity GO:0005125 8.92 IFNG IL13 IL4 IL5

Sources for Urinary Schistosomiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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