MCID: URN022
MIFTS: 27

Urinary Tract Infections, Recurrent

Categories: Infectious diseases, Nephrological diseases

Aliases & Classifications for Urinary Tract Infections, Recurrent

MalaCards integrated aliases for Urinary Tract Infections, Recurrent:

Name: Urinary Tract Infections, Recurrent 57
Urinary Tract Infections, Recurrent, Susceptibility to 57 29
Recurrent Urinary Tract Infections 29 6
Urinary Tract Infection Recurrent 54
Recurrent Urinary Tract Infection 70

Classifications:



External Ids:

OMIM® 57 603806
UMLS 70 C0262655

Summaries for Urinary Tract Infections, Recurrent

MalaCards based summary : Urinary Tract Infections, Recurrent, also known as urinary tract infections, recurrent, susceptibility to, is related to vesicoureteral reflux 1 and acute cystitis. An important gene associated with Urinary Tract Infections, Recurrent is EBF3 (EBF Transcription Factor 3). The drugs Trimethoprim and Hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, spinal cord and adrenal gland.

More information from OMIM: 603806

Related Diseases for Urinary Tract Infections, Recurrent

Diseases in the Urinary Tract Infection family:

Urinary Tract Infections, Recurrent

Diseases related to Urinary Tract Infections, Recurrent via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 119)
# Related Disease Score Top Affiliating Genes
1 vesicoureteral reflux 1 30.1 EBF3 CXCR1
2 acute cystitis 11.4
3 bladder dysfunction, autonomic, with impaired pupillary reflex and secondary cakut 11.3
4 urinary tract infection 11.3
5 polycystic kidney disease 11.2
6 ectrodactyly and ectodermal dysplasia without cleft lip/palate 11.2
7 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 11.2
8 hand-foot-genital syndrome 11.2
9 lacrimoauriculodentodigital syndrome 11.2
10 hypomagnesemia 3, renal 11.2
11 cakut 11.2
12 actg2-related disorders 11.2
13 familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis 11.2
14 hereditary xanthinuria 11.2
15 urachal diverticulum 11.2
16 cystitis 10.8
17 bacteriuria 10.8
18 pyelonephritis 10.7
19 bacterial infectious disease 10.6
20 neurogenic bladder 10.6
21 interstitial cystitis 10.5
22 pyuria 10.5
23 chronic pyelonephritis 10.4
24 constipation 10.4
25 acute pyelonephritis 10.3
26 urolithiasis 10.3
27 prostatitis 10.3
28 spinal cord injury 10.3
29 sexual disorder 10.2
30 drug allergy 10.2
31 rickets 10.2
32 hydronephrosis 10.2
33 low compliance bladder 10.2
34 cystitis cystica 10.2
35 prostatic hyperplasia, benign 10.2
36 myelomeningocele 10.2
37 prostatic hypertrophy 10.2
38 postmenopausal atrophic vaginitis 10.2
39 detrusor sphincter dyssynergia 10.2
40 trigonitis 10.2
41 vaginitis 10.2
42 pyelitis 10.2
43 prostatic adenoma 10.2
44 urinary tract obstruction 10.2
45 paraplegia 10.2
46 diverticulitis 10.2
47 48,xyyy 10.2
48 autoimmune disease 10.0
49 bladder cancer 10.0
50 bladder diverticulum 10.0

Graphical network of the top 20 diseases related to Urinary Tract Infections, Recurrent:



Diseases related to Urinary Tract Infections, Recurrent

Symptoms & Phenotypes for Urinary Tract Infections, Recurrent

Clinical features from OMIM®:

603806 (Updated 20-May-2021)

Drugs & Therapeutics for Urinary Tract Infections, Recurrent

Drugs for Urinary Tract Infections, Recurrent (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
2
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
3
Methyltestosterone Approved Phase 4 58-18-4 6010
4
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
5
Testosterone enanthate Approved Phase 4 315-37-7 9416
6
Testosterone Approved, Investigational Phase 4 58-22-0 6013
7
Methenamine Approved, Vet_approved Phase 4 100-97-0 4101
8
Fosfomycin Approved Phase 4 23155-02-4 446987
9
Amikacin Approved, Investigational, Vet_approved Phase 4 37517-28-5 37768
10
Cephalexin Approved, Investigational, Vet_approved Phase 4 15686-71-2 27447
11
Tobramycin Approved, Investigational Phase 4 32986-56-4 5496 36294
12 Acidophilus Phase 4
13 Anti-Infective Agents, Local Phase 4
14 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
15
Chondroitin Phase 4 9007-27-6 14389182
16 Emollients Phase 4
17 Testosterone 17 beta-cypionate Phase 4
18 Androgens Phase 4
19 Methenamine mandelate Phase 4
20 Methenamine hippurate Phase 4
21 Antitubercular Agents Phase 4
22
Polyestradiol phosphate Approved Phase 3 28014-46-2
23
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
24
Dehydroepiandrosterone Approved, Investigational, Nutraceutical Phase 3 53-43-0 5881
25 Adjuvants, Immunologic Phase 3
26 DHEA (Dehydroepiandrosterone) Phase 3
27 Immunologic Factors Phase 3
28 Estrogens Phase 3
29 Hormones Phase 3
30 Hormone Antagonists Phase 3
31 Estradiol 3-benzoate Phase 3
32 Estradiol 17 beta-cypionate Phase 3
33
Heparin Approved, Investigational Phase 2 9005-49-6 772 9812414
34
Prulifloxacin Investigational Phase 2 123447-62-1
35 Soy Bean Phase 2
36 Fibrinolytic Agents Phase 2
37 Anticoagulants Phase 2
38 calcium heparin Phase 2
39 Calcium, Dietary Phase 1, Phase 2
40 Vaccines Phase 2
41
Calcium Nutraceutical Phase 1, Phase 2 7440-70-2 271
42 Anthocyanidin Phase 1
43 Proanthocyanidin Phase 1
44
Procyanidin Phase 1 4852-22-6 147299
45
Ofloxacin Approved 82419-36-1 4583
46
Levofloxacin Approved, Investigational 100986-85-4 149096
47
Amoxicillin Approved, Vet_approved 26787-78-0 33613
48
Cefuroxime Approved 55268-75-2 5361202 5479529
49
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved 83-88-5 493570
50
Vitamin C Approved, Nutraceutical 50-81-7 5785 54670067

Interventional clinical trials:

(show top 50) (show all 58)
# Name Status NCT ID Phase Drugs
1 A Randomised, Double-blind, Placebo Controlled Trial Evaluating the Effectiveness of a Cranberry Concentrate (CranrichTM) in Preventing Recurrent Urinary Tract Infections in Adult Women Unknown status NCT02454309 Phase 4
2 Low Dose Estriol With Lactobacilli (Gynoflor) Treatment for Preventing Recurrent Urinary Tract Infection in Postmenopausal Women: A Randomized, Open, Parallel-Group Study Unknown status NCT00900653 Phase 4 Gynoflor E (low dose estriol with lactobacillus)
3 Antibiotic Treatment for Intermittent Bladder Catheterisation: A Randomised Controlled Trial of Once Daily Prophylaxis Completed NCT02145338 Phase 4 Nitrofurantoin or Trimethoprim or Cefalexin
4 Methenamine Hippurate Versus Trimethoprim in the Prevention of Recurrent UTIs Completed NCT03077711 Phase 4 Trimethoprim;Methenamine hippurate
5 Vaginal Estrogen for the Prevention of Recurrent Urinary Tract Infection in Postmenopausal Women: A Randomized Clinical Trial Completed NCT01958073 Phase 4 Conjugated Estrogen Vaginal Cream;Estradiol Ring;Placebo
6 Recurrent Urinary Tract Infections in Children: Bacterial Identification, Antibiotic Susceptibility Profiling and Cytokine Levels Associated With Antibiotic Prophylaxis Completed NCT02357758 Phase 4 Antibiotic Prophylaxis
7 Prevention of Recurrent Urinary Tract Infection Using Vaginal Testosterone Versus Placebo Recruiting NCT04807894 Phase 4 Vaginal Cream with Applicator
8 Efficacy and Mechanism of Action of Methenamine Hippurate (Hiprex™) in the Management of Recurrent Urinary Tract Infections in Women Recruiting NCT04709601 Phase 4 Hiprex
9 Non-antimicrobial Alternative in Prophylaxis of Recurrent Urinary Tract Infections: a Prospective, Randomised-controlled, Double-blinded, Multicentre Study Recruiting NCT04095572 Phase 4 intravesical instillation with HA-CS;intravesical instillation of sterile purified water
10 The Effect of Methenamine Hippurate to Reduce Antibiotic Prescribing Due to New Episodes of Urinary Tract Infections (UTI) in Elderly Women With Recurrent UTI - a Triple- Blinded, Randomized Placebo-controlled Phase IV Study Enrolling by invitation NCT04077580 Phase 4 Methenamine Hippurate 1000 MG
11 Intravesical Antibiotic Instillations Versus Oral Suppression for the Treatment of Recurrent Urinary Tract Infections in Post-menopausal Women Not yet recruiting NCT04285320 Phase 4 Intravesical antibiotic instillation;Antibiotic oral suppressive therapy
12 Preventing Recurrent Urinary Tract Infections With α-D-mannose: a Prospective, Randomized, Double-blinded Placebo-controlled Trial Terminated NCT03497598 Phase 4 Mannose;Lactose
13 A Randomized, Double-blind, Placebo Controlled Trial Evaluating the Effectiveness of a Cranberry Concentrate in Preventing Recurrent Urinary Tract Infections in Adult Women Withdrawn NCT01881165 Phase 4 Cranberry;Placebo
14 INtravesical Antimicrobial Agents Versus STANDard Oral Antibiotics for the Treatment of Acute Urinary Tract Infection in Women With Recurrent Urinary Tract Infection (INSTANT Study) Withdrawn NCT03299387 Phase 4 Nitrofurantoin;Gentamicin
15 Recurrent Urinary Tract Infections in Adult Women: a Pilot Study With Oral D Mannose Completed NCT01808755 Phase 3 trimethoprim/sulfamethoxazole
16 Randomized, Controlled Trial to Determine the Efficacy of Nutraceutical vs Control as Non-antibiotic Prophylaxis for Recurrent Urinary Tract Infection in Postmenopausal Women Using Vaginal Estrogen Therapy Recruiting NCT03395288 Phase 2, Phase 3 D-Mannose
17 A Randomized, Double-blind, Placebo-controlled Trial on the Preventive Effect of Intravaginal Prasterone (DHEA, Intrarosa®) on Recurrent Urinary Tract Infections in Women With Genitourinary Syndrome of Menopause Not yet recruiting NCT03854396 Phase 3 Prasterone;Placebo
18 Preventive Effect of Treatment With Estradiol Vaginal Tablets on Recurrent Urinary Tract Infections in Post-menopausal Women (RUTI) in Post-menopausal Women With Signs of Urogenital Ageing (UGA) Terminated NCT00560924 Phase 3 estradiol, 25 mcg
19 Efficacy of Prulifloxacin vs Phosphomycin in the Prophylasy of Urinary Tract Infection Unknown status NCT01231737 Phase 2 prulifloxacin
20 A Clinical Trial to Determine the Extent to Which Probiotic Therapy Reduces Side Effects of Antibiotic Prophylaxis in Pediatric Neurogenic Bladder Patients With a History of Recurrent Urinary Tract Infections Unknown status NCT02044965 Phase 1, Phase 2 Probiotic
21 Phase 2 Clinical Trial of Vaginal Mucosal Immunization for Recurrent Urinary Tract Infections Completed NCT00261248 Phase 2
22 Intravaginal LACTIN-V for Prevention of Recurrent Urinary Tract Infections Completed NCT00305227 Phase 2 Lactin-V;Placebo
23 A Randomised, Double-blind, Placebo Controlled Study to Investigate the Efficacy and Safety of High Strength Cranberry (Pacran®) in Women With Recurrent Urinary Tract Infections (Cystitis) Completed NCT03042273 Phase 2
24 Heparin Intraoperative Instillation for Lower Urinary Tract Symptoms After Benign Hysterectomy: A Randomized Controlled Trial Recruiting NCT03633994 Phase 2 Heparin;Normal saline
25 Recurrent Urinary Tract Infections and Heparin: a Double-blind Randomized Trial (RUTIH Trial) Recruiting NCT02246270 Phase 1, Phase 2 Intravesical Heparin
26 Protocol 19-01: Canadian, Single Centre, Pilot, Open Label Study to Evaluate the Efficacy and Safety of the Bacterial Vaccine Uromune in Treating Recurrent Urinary Tract Infections in Women. Recruiting NCT04096820 Phase 2
27 Fecal Microbiota Transplantation Using RBX2660 for the Prevention of Recurrent Urinary Tract Infections Due to Multidrug Resistant Organisms Active, not recruiting NCT03367910 Phase 1, Phase 2 Fecal microbiota transplant
28 H-23187: Probiotic Prophylaxis Against Recurrent Pediatric Urinary Tract Infection Withdrawn NCT00789464 Phase 2 trimethoprim/sulfamethoxazole
29 Recurrent Urinary Tract Infection Prevention With Biologic Cranberry Extract Intake Standardized in Proanthocyanidins: A Double-blind Clinical Trial Unknown status NCT02572895 Phase 1
30 Evaluation of a Candidate Vaccine Against Uropathogenic Escherichia Coli in Women With a Clinical History of Recurrent Urinary Tract Infection Completed NCT02289794 Phase 1
31 Study on Treatment of Recurrent Urinary Tract Infection by Traditional Chinese Medicine Unknown status NCT01745328 LVX-AMX;TCM;LVX-AMX
32 To Investigate and Compare The Efficacy of Urethral Dilatation Versus Glycosaminoglycan Layer Replacement in The Management Of Women With Recurrent Urinary Tract Infections Unknown status NCT03861260
33 INTRAVESICAL ADMINISTRATION OF COMBINED HYALURONIC ACID (HA) AND CHONDROITIN SULPHATE (CS) vs. STANDARD OF CARE FOR THE TREATMENT OF RECURRENT URINARY TRACT INFECTIONS (RUTIs) Unknown status NCT02016118
34 Prophylactic Use of Cranberries in Recurrent Bacterial Cystitis in Women: A Randomized, Comparative, Study. Unknown status NCT03032003
35 Safety and Tolerability of Controlled Human Urine Transfusion for Urinary Tract Infection Prevention (SHUTUP): a Pilot Study Unknown status NCT03142295
36 Identification of Predictive Blood Biomarkers of Recurrent Urinary Tract Infections Unknown status NCT03819712
37 Oral D Mannose in the Prevention and Treatment of Recurrent Urinary Tract Infections: a Systematic Review Completed NCT03790254
38 Fecal Microbiota Transplantation for the Treatment of Recurrent Urinary Tract Completed NCT03050515 Early Phase 1
39 A Randomized, Double-blind, Placebo-controlled Clinical Study to Assess the Use of Nanotechnology Structured Water Magnalife for the Prevention of Recurrent Urinary Tract Infections. Completed NCT04306731 Trimethoprim
40 The Effect of Increased Water Intake on the Frequency of the Clinical Recurrent Urinary Tract Infections in Pre-menopausal Women: S-HYDRACYST Completed NCT02444975
41 Association Between Deficiency of MBL (Mannose-Binding Lectin) and Polymorphisms in MBL2 Gene to Urinary Tract Infection Completed NCT00678028
42 A Double-blinded, Randomized, Placebo-controlled, Parallel-group Study Evaluating the Effect of the Probiotic on Recurrent Urinary Tract Infection (UTI) in Adult Women Recently Treated for UTI. Completed NCT03366077
43 Induced Asymptomatic E. Coli 83972 Bacteriuria in Patients With Recurrent Urinary Tract Infections and Bladder Dysfunction- is There a Protective Effect Against Recurrent Symptomatic Infections? A Blinded Placebo Controlled Cross-over Study. Completed NCT00927316
44 Observational Study With Mode of Action-Analysis of Cystorenal Cranberry Extract in Patients With Recurrent Urinary Tract Infections Completed NCT03019874
45 The Efficacy of Preventive Antibiotic Treatment During the Puerperium Among Pregnant Women With Recurrent Urinary Tract Infections Completed NCT01507974 Preventive antibiotic treatment- NITROFURANTOIN;Preventive antibiotic treatment- CEPHALEXIN;PREVENTIVE TREATMENT- AMOXICILLIN;PREVENTIVE TREATMENT- AMOXICILLIN AND CLAVULANATE POTASSIUM;PREVENTIVE TREATMENT- CEFUROXIME;PREVENTIVE TREATMENT SULFAMETHOXAZOLE AND TRIMETHOPRIM
46 Clinical Value of Homeopathic Assessment and Treatment for Prophylaxis of Recurrent Urinary Tract Infections in Persons With Spinal Cord Injury Completed NCT01477502
47 Role of Clinical and Urodynamic Risk Factors for Recurrent Urinary Tract Infection in 5-18 Years Old Children Completed NCT00528476
48 A Study of Vaginal MicroFlora and Immune Profiles of Patients With Recurrent Urinary Tract Infection Completed NCT00216853
49 Hyperbaric Oxygen Therapy for Inflammatory Conditions of the Urinary Bladder: A Feasibility Trial Recruiting NCT03143920 Early Phase 1
50 Segmental and Ear Acupuncture for Prevention of Recurrent Urinary Tract Infections(SARUTI Study): a Multicenter Randomized Controlled Trial Recruiting NCT02705495 Cranberry products

Search NIH Clinical Center for Urinary Tract Infections, Recurrent

Genetic Tests for Urinary Tract Infections, Recurrent

Genetic tests related to Urinary Tract Infections, Recurrent:

# Genetic test Affiliating Genes
1 Recurrent Urinary Tract Infections 29
2 Urinary Tract Infections, Recurrent, Susceptibility to 29

Anatomical Context for Urinary Tract Infections, Recurrent

MalaCards organs/tissues related to Urinary Tract Infections, Recurrent:

40
Kidney, Spinal Cord, Adrenal Gland

Publications for Urinary Tract Infections, Recurrent

Articles related to Urinary Tract Infections, Recurrent:

(show all 15)
# Title Authors PMID Year
1
Whole-genome sequencing of patients with rare diseases in a national health system. 6
32581362 2020
2
Evaluation of a familial predisposition to recurrent urinary tract infections in women. 57
10232756 1999
3
The role of excretory urography and cystoscopy in the evaluation and management of women with recurrent urinary tract infection. 57
7354514 1980
4
URINARY TRACT INFECTION IN SCHOOL CHILDREN: AN EPIDEMIOLOGIC, CLINICAL AND LABORATORY STUDY. 57
14129871 1964
5
Administration of nitrofurantoin in dogs with lower urinary tract infections: 14 cases (2013-2019). 61
33107048 2021
6
Outcomes of Kidney Transplant Recipients With Posttransplant Genitourinary Infectious Complications: A Single Center Study. 61
30381050 2019
7
Uro-Vaxom® versus placebo for the prevention of recurrent symptomatic urinary tract infections in participants with chronic neurogenic bladder dysfunction: a randomised controlled feasibility study. 61
30992071 2019
8
Post-transplantation Infections in Bolivia. 61
27110022 2016
9
Clinical experience with the Swiss lithoclast master in treatment of bladder calculi. 61
23384337 2014
10
Urinary tract infections in the elderly population. 61
21840265 2011
11
Change of urodynamic patterns in infants with dilating vesicoureteral reflux: 3-year followup. 61
19765771 2009
12
Enterovesical fistula: a rare complication of urethral catheterization. 61
19657455 2009
13
Impact of Toll-like receptor signalling on urinary tract infection. 54
17942281 2008
14
Expression of interleukin-8 receptors (CXCR1 and CXCR2) in premenopausal women with recurrent urinary tract infections. 54
16339057 2005
15
Differences in antibiotic prescribing patterns between general practitioners in Scandinavia: a questionnaire study. 61
12238578 2002

Variations for Urinary Tract Infections, Recurrent

ClinVar genetic disease variations for Urinary Tract Infections, Recurrent:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 EBF3 NM_001005463.3(EBF3):c.280_283del (p.Glu94fs) Deletion Pathogenic 375502 rs1057519521 GRCh37: 10:131761639-131761642
GRCh38: 10:129963375-129963378

Expression for Urinary Tract Infections, Recurrent

Search GEO for disease gene expression data for Urinary Tract Infections, Recurrent.

Pathways for Urinary Tract Infections, Recurrent

GO Terms for Urinary Tract Infections, Recurrent

Sources for Urinary Tract Infections, Recurrent

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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