MCID: URN011
MIFTS: 28

Urinary Tract Papillary Transitional Cell Benign Neoplasm

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Urinary Tract Papillary Transitional Cell Benign Neoplasm

MalaCards integrated aliases for Urinary Tract Papillary Transitional Cell Benign Neoplasm:

Name: Urinary Tract Papillary Transitional Cell Benign Neoplasm 12 15
Papillary Transitional Cell Neoplasm of the Urinary Tract 12
Inverted Papilloma of Urinary Tract 12
Urinary Tract Inverted Papilloma 12
Inverted Urothelial Papilloma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5433
NCIt 50 C27883 C6192
SNOMED-CT 67 733845009
UMLS 70 C1334282 C1335329

Summaries for Urinary Tract Papillary Transitional Cell Benign Neoplasm

MalaCards based summary : Urinary Tract Papillary Transitional Cell Benign Neoplasm, also known as papillary transitional cell neoplasm of the urinary tract, is related to papilloma and inverted papilloma. An important gene associated with Urinary Tract Papillary Transitional Cell Benign Neoplasm is FGFR3 (Fibroblast Growth Factor Receptor 3), and among its related pathways/superpathways is Bladder cancer. Affiliated tissues include lung, thyroid and appendix.

Related Diseases for Urinary Tract Papillary Transitional Cell Benign Neoplasm

Diseases related to Urinary Tract Papillary Transitional Cell Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 papilloma 30.5 TP53 KRT20 FGFR3
2 inverted papilloma 30.4 TP53 KRT20
3 transitional cell carcinoma 29.9 UPK3A TP53 KRT20 FGFR3 BRINP1
4 actinic cheilitis 10.3 TP53 FGFR3
5 cheilitis 10.3 TP53 FGFR3
6 intratubular embryonal carcinoma 10.3 TP53 KRT20
7 eccrine sweat gland cancer 10.3 TP53 KRT20
8 sweat gland cancer 10.3 TP53 KRT20
9 clear cell basal cell carcinoma 10.3 TP53 KRT20
10 urethral benign neoplasm 10.3 TP53 KRT20
11 appendix disease 10.3 TP53 KRT20
12 peritoneal serous adenocarcinoma 10.3 TP53 KRT20
13 human papillomavirus infectious disease 10.3 TP53 TERT
14 appendix cancer 10.3 TP53 KRT20
15 bile duct adenoma 10.3 TP53 KRT20
16 thyroid angiosarcoma 10.3 TERT KRT20
17 ovarian benign neoplasm 10.3 TP53 KRT20
18 intrahepatic bile duct adenoma 10.3 TP53 KRT20
19 urethra transitional cell carcinoma 10.3 UPK3A TP53
20 acanthoma 10.3 TP53 FGFR3
21 granulosa cell tumor of the ovary 10.3 TP53 TERT
22 mixed oligodendroglioma-astrocytoma 10.3 TP53 TERT
23 vulva adenocarcinoma 10.3 UPK3A KRT20
24 borst-jadassohn intraepidermal carcinoma 10.3 TP53 KRT20
25 ovarian brenner tumor 10.2 UPK3A KRT20
26 invasive bladder transitional cell carcinoma 10.2 UPK3A TP53
27 dyskeratosis congenita autosomal recessive 10.2 TP53 TERT
28 duodenum cancer 10.2 TP53 KRT20
29 urethra clear cell adenocarcinoma 10.2 UPK3A KRT20
30 liver benign neoplasm 10.2 TP53 TERT
31 bladder adenocarcinoma 10.2 UPK3A KRT20
32 renal hypodysplasia/aplasia 3 10.2 UPK3A FGFR3
33 ureter, cancer of 10.2 TERT FGFR3
34 chronic cystitis 10.2 UPK3A KRT20
35 papillary serous adenocarcinoma 10.2 TP53 KRT20
36 bladder sarcoma 10.2 UPK3A KRT20
37 basaloid squamous cell carcinoma 10.2 TP53 KRT20
38 pseudomyxoma peritonei 10.2 TP53 KRT20
39 chronic cervicitis 10.2 ZKSCAN3 TP53
40 teratoma 10.2 TP53 KRT20 FGFR3
41 villous adenoma 10.2 TP53 KRT20
42 squamous cell papilloma 10.1
43 rare tumor 10.1
44 lung benign neoplasm 10.1 TP53 TERT KRT20
45 t-cell adult acute lymphocytic leukemia 10.1 TP53 CNTN2
46 colorectal adenocarcinoma 10.1 TP53 TERT KRT20
47 signet ring cell adenocarcinoma 10.1 TP53 KRT20
48 ureteral benign neoplasm 10.1 ZKSCAN3 UPK3A
49 glandular cystitis 10.1 UPK3A TP53 KRT20
50 progressive pseudorheumatoid dysplasia 10.1 CCN6 CCN1

Graphical network of the top 20 diseases related to Urinary Tract Papillary Transitional Cell Benign Neoplasm:



Diseases related to Urinary Tract Papillary Transitional Cell Benign Neoplasm

Symptoms & Phenotypes for Urinary Tract Papillary Transitional Cell Benign Neoplasm

Drugs & Therapeutics for Urinary Tract Papillary Transitional Cell Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Urinary Tract Papillary Transitional Cell Benign Neoplasm

Genetic Tests for Urinary Tract Papillary Transitional Cell Benign Neoplasm

Anatomical Context for Urinary Tract Papillary Transitional Cell Benign Neoplasm

MalaCards organs/tissues related to Urinary Tract Papillary Transitional Cell Benign Neoplasm:

40
Lung, Thyroid, Appendix, Cervix, Liver, Ovary

Publications for Urinary Tract Papillary Transitional Cell Benign Neoplasm

Articles related to Urinary Tract Papillary Transitional Cell Benign Neoplasm:

# Title Authors PMID Year
1
Upper urinary tract inverted papillomas: Report of 10 cases. 61
22807963 2012
2
Inverted transitional cell papilloma of the uterine cervix. 61
11842379 2002

Variations for Urinary Tract Papillary Transitional Cell Benign Neoplasm

Cosmic variations for Urinary Tract Papillary Transitional Cell Benign Neoplasm:

9 (show top 50) (show all 65)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM112988925 HRAS urinary tract,NS,papilloma,inverted c.181C>A p.Q61K 11:533875-533875 12
2 COSM91331243 HRAS urinary tract,NS,papilloma,inverted c.181C>A p.Q61K 11:533875-533875 12
3 COSM101951686 HRAS urinary tract,NS,papilloma,inverted c.181C>A p.Q61K 11:533875-533875 12
4 COSM101967342 HRAS urinary tract,NS,papilloma,inverted c.181C>A p.Q61K 11:533875-533875 12
5 COSM105721476 HRAS urinary tract,NS,papilloma,inverted c.181C>A p.Q61K 11:533875-533875 12
6 COSM102794588 FGFR3 urinary tract,NS,papilloma,inverted c.742C>T p.R248C 4:1801837-1801837 12
7 COSM90922619 FGFR3 urinary tract,NS,papilloma,inverted c.796G>A p.V266M 4:1801891-1801891 12
8 COSM102817661 FGFR3 urinary tract,NS,papilloma,inverted c.1545G>T p.E515D 4:1806095-1806095 12
9 COSM90920128 FGFR3 urinary tract,NS,papilloma,inverted c.1242C>T p.H414= 4:1804490-1804490 12
10 COSM107633928 FGFR3 urinary tract,NS,papilloma,inverted c.1927C>G p.H643D 4:1806141-1806141 12
11 COSM142951575 FGFR3 urinary tract,NS,papilloma,inverted c.775C>T p.L259= 4:1801870-1801870 12
12 COSM90912543 FGFR3 urinary tract,NS,papilloma,inverted c.775C>T p.L259= 4:1801870-1801870 12
13 COSM115704956 FGFR3 urinary tract,NS,papilloma,inverted c.746C>G p.S249C 4:1801841-1801841 12
14 COSM102794222 FGFR3 urinary tract,NS,papilloma,inverted c.746C>G p.S249C 4:1801841-1801841 12
15 COSM91805120 FGFR3 urinary tract,NS,papilloma,inverted c.775C>T p.L259= 4:1801870-1801870 12
16 COSM91816713 FGFR3 urinary tract,NS,papilloma,inverted c.745T>A p.S249T 4:1801840-1801840 12
17 COSM115719540 FGFR3 urinary tract,NS,papilloma,inverted c.1960A>C p.N654H 4:1806171-1806171 12
18 COSM91802278 FGFR3 urinary tract,NS,papilloma,inverted c.746C>G p.S249C 4:1801841-1801841 12
19 COSM90910564 FGFR3 urinary tract,NS,papilloma,inverted c.742C>T p.R248C 4:1801837-1801837 12
20 COSM107634786 FGFR3 urinary tract,NS,papilloma,inverted c.1236C>T p.H412= 4:1804490-1804490 12
21 COSM107625086 FGFR3 urinary tract,NS,papilloma,inverted c.746C>G p.S249C 4:1801841-1801841 12
22 COSM142950333 FGFR3 urinary tract,NS,papilloma,inverted c.742C>T p.R248C 4:1801837-1801837 12
23 COSM90932095 FGFR3 urinary tract,NS,papilloma,inverted c.1887G>T p.E629D 4:1806095-1806095 12
24 COSM107637911 FGFR3 urinary tract,NS,papilloma,inverted c.745T>A p.S249T 4:1801840-1801840 12
25 COSM91802800 FGFR3 urinary tract,NS,papilloma,inverted c.742C>T p.R248C 4:1801837-1801837 12
26 COSM142956265 FGFR3 urinary tract,NS,papilloma,inverted c.*292C>T p.? 4:1804490-1804490 12
27 COSM102796829 FGFR3 urinary tract,NS,papilloma,inverted c.775C>T p.L259= 4:1801870-1801870 12
28 COSM115718544 FGFR3 urinary tract,NS,papilloma,inverted c.745T>A p.S249T 4:1801840-1801840 12
29 COSM90919415 FGFR3 urinary tract,NS,papilloma,inverted c.1933C>G p.H645D 4:1806141-1806141 12
30 COSM107625421 FGFR3 urinary tract,NS,papilloma,inverted c.742C>T p.R248C 4:1801837-1801837 12
31 COSM102810810 FGFR3 urinary tract,NS,papilloma,inverted c.1621A>C p.N541H 4:1806171-1806171 12
32 COSM115714115 FGFR3 urinary tract,NS,papilloma,inverted c.1930C>G p.H644D 4:1806141-1806141 12
33 COSM102804555 FGFR3 urinary tract,NS,papilloma,inverted c.1591C>G p.H531D 4:1806141-1806141 12
34 COSM142950046 FGFR3 urinary tract,NS,papilloma,inverted c.746C>G p.S249C 4:1801841-1801841 12
35 COSM115705346 FGFR3 urinary tract,NS,papilloma,inverted c.742C>T p.R248C 4:1801837-1801837 12
36 COSM115707354 FGFR3 urinary tract,NS,papilloma,inverted c.775C>T p.L259= 4:1801870-1801870 12
37 COSM90923995 FGFR3 urinary tract,NS,papilloma,inverted c.745T>A p.S249T 4:1801840-1801840 12
38 COSM102805364 FGFR3 urinary tract,NS,papilloma,inverted c.931-334C>T p.? 4:1804490-1804490 12
39 COSM90909874 FGFR3 urinary tract,NS,papilloma,inverted c.746C>G p.S249C 4:1801841-1801841 12
40 COSM115717305 FGFR3 urinary tract,NS,papilloma,inverted c.796G>A p.V266M 4:1801891-1801891 12
41 COSM91811841 FGFR3 urinary tract,NS,papilloma,inverted c.1591C>G p.H531D 4:1806141-1806141 12
42 COSM90925211 FGFR3 urinary tract,NS,papilloma,inverted c.1963A>C p.N655H 4:1806171-1806171 12
43 COSM142951584 FGFR3 urinary tract,NS,papilloma,inverted c.*977G>A p.? 4:1806135-1806135 12
44 COSM107627424 FGFR3 urinary tract,NS,papilloma,inverted c.775C>T p.L259= 4:1801870-1801870 12
45 COSM91823729 FGFR3 urinary tract,NS,papilloma,inverted c.1545G>T p.E515D 4:1806095-1806095 12
46 COSM142960037 FGFR3 urinary tract,NS,papilloma,inverted c.*1013A>C p.? 4:1806171-1806171 12
47 COSM102807783 FGFR3 urinary tract,NS,papilloma,inverted c.796G>A p.V266M 4:1801891-1801891 12
48 COSM142959260 FGFR3 urinary tract,NS,papilloma,inverted c.745T>A p.S249T 4:1801840-1801840 12
49 COSM91814789 FGFR3 urinary tract,NS,papilloma,inverted c.796G>A p.V266M 4:1801891-1801891 12
50 COSM91805129 FGFR3 urinary tract,NS,papilloma,inverted c.1585G>A p.D529N 4:1806135-1806135 12

Expression for Urinary Tract Papillary Transitional Cell Benign Neoplasm

Search GEO for disease gene expression data for Urinary Tract Papillary Transitional Cell Benign Neoplasm.

Pathways for Urinary Tract Papillary Transitional Cell Benign Neoplasm

Pathways related to Urinary Tract Papillary Transitional Cell Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.66 UPK3A TP53 FGFR3

GO Terms for Urinary Tract Papillary Transitional Cell Benign Neoplasm

Cellular components related to Urinary Tract Papillary Transitional Cell Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 8.92 CCN6 CCN5 CCN4 CCN1

Biological processes related to Urinary Tract Papillary Transitional Cell Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of mitotic cell cycle GO:0045930 9.46 TP53 BRINP1
2 cell-cell signaling GO:0007267 9.46 FGFR3 CCN6 CCN5 CCN4
3 positive regulation of Wnt signaling pathway GO:0030177 9.43 TERT CCN4
4 cell adhesion GO:0007155 9.43 SIGLEC12 CNTN2 CCN6 CCN5 CCN4 CCN1
5 negative regulation of cellular senescence GO:2000773 9.4 ZKSCAN3 TERT
6 replicative senescence GO:0090399 9.37 TP53 TERT
7 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.32 TP53 TERT
8 positive regulation of phospholipase activity GO:0010518 9.26 FGFR3 CCN1
9 negative regulation of cell death GO:0060548 8.92 CCN6 CCN5 CCN4 CCN1

Molecular functions related to Urinary Tract Papillary Transitional Cell Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.46 CCN6 CCN5 CCN4 CCN1
2 integrin binding GO:0005178 9.26 CCN6 CCN5 CCN4 CCN1
3 insulin-like growth factor binding GO:0005520 8.92 CCN6 CCN5 CCN4 CCN1

Sources for Urinary Tract Papillary Transitional Cell Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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