Categories: Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Urticaria

MalaCards integrated aliases for Urticaria:

Name: Urticaria 12 73 29 54 6 15 17 70 32


External Ids:

Disease Ontology 12 DOID:1555
ICD9CM 34 708.8
SNOMED-CT 67 267817001
ICD10 32 L50 L50.2 L50.9
UMLS 70 C0029839 C0042109

Summaries for Urticaria

Disease Ontology : 12 A skin disease characterized by skin rash notable for pale red, raised and itchy bumps, located in the upper dermis.

MalaCards based summary : Urticaria is related to cold urticaria and physical urticaria, and has symptoms including nausea and vomiting, constipation and fatigue. An important gene associated with Urticaria is F12 (Coagulation Factor XII), and among its related pathways/superpathways are NF-kappaB Signaling and Linoleic acid metabolism. The drugs Levoleucovorin and Dapsone have been mentioned in the context of this disorder. Affiliated tissues include upper dermis, skin and thyroid.

Wikipedia : 73 Hives, also known as urticaria, is a kind of skin rash with red, raised, itchy bumps. They may also burn... more...

Related Diseases for Urticaria

Diseases in the Urticaria family:

Chronic Urticaria Rare Urticaria

Diseases related to Urticaria via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 728)
# Related Disease Score Top Affiliating Genes
1 cold urticaria 33.0 RNASE3 PLCG2 NLRP3 CMA1
2 physical urticaria 32.9 TPT1 NLRP3 HRH1 ADGRE2
3 dermatographia 32.6 TPT1 PRG2 IGHE
4 chronic urticaria 32.6 TPT1 RNASE3 PTGS1 NLRP3 IGHE HRH1
5 paragonimiasis 31.7 RNASE3 IGHE
6 dermatitis 31.3 RNASE3 IGHE FCER2 CMA1
7 angioedema 31.2 SLC34A1 PTGS2 PTGS1 LTC4S IGHE HRH1
8 allergic rhinitis 31.1 TPT1 RNASE3 IGHE HRH1 FCER2
9 occupational asthma 31.0 TPT1 IGHE
10 allergic disease 30.9 RNASE3 PRG2 IGHE HRH1 FCER2
11 conjunctivitis 30.9 RNASE3 NLRP3 IGHE HRH1
12 dermatitis, atopic 30.8 RNASE3 PRG2 IGHE HRH1 FCER2 CMA1
13 hypereosinophilic syndrome 30.8 RNASE3 PRG2 IGHE
14 rhinitis 30.8 TPT1 RNASE3 PTGS1 PRG2 IGHE HRH1
15 food allergy 30.8 TPT1 RNASE3 IGHE HRH1 FCER2 AOC1
16 anisakiasis 30.7 RNASE3 IGHE
17 autoinflammatory syndrome 30.7 PLCG2 NLRP3
18 respiratory allergy 30.6 RNASE3 IGHE AOC1
19 pollen allergy 30.6 RNASE3 PRG2 IGHE
20 toxocariasis 30.6 RNASE3 IGHE
21 hereditary angioedema 30.5 SLC34A1 F12 CPN1 C1S
22 gastrointestinal ulceration, recurrent, with dysfunctional platelets 30.4 PTGS2 PTGS1
23 chronic rhinitis 30.3 RNASE3 PRG2 HRH1
24 wells syndrome 30.2 RNASE3 NLRP3
25 proteasome-associated autoinflammatory syndrome 1 30.2 RNASE3 PTGS2 PTGS1 NLRP3 IGHE
26 esophagitis 30.1 RNASE3 PTGS2 PRG2
27 malaria 30.1 TPT1 RNASE3 PTGS2 PTGS1 NLRP3 HRH1
28 bullous pemphigoid 30.0 RNASE3 IGHE FCER2
29 c1 inhibitor deficiency 30.0 SLC34A1 F12 C1S
30 hydrops, lactic acidosis, and sideroblastic anemia 30.0 PTGS2 PTGS1 C1S
31 allergic conjunctivitis 30.0 RNASE3 IGHE HRH1
32 active peptic ulcer disease 29.9 PTGS2 PTGS1
33 vasomotor rhinitis 29.9 RNASE3 CMA1
34 asthma 29.8 TPT1 RNASE3 PTGS1 PRG2 NLRP3 LTC4S
35 vibratory urticaria 11.7
36 mastocytosis, cutaneous 11.6
37 chronic spontaneous urticaria 11.6
38 muckle-wells syndrome 11.5
39 familial cold autoinflammatory syndrome 3 11.5
40 urticaria, aquagenic 11.5
41 cholinergic urticaria 11.5
42 solar urticaria 11.5
43 allergic urticaria 11.5
44 schnitzler syndrome 11.4
45 familial cold autoinflammatory syndrome 11.4
46 familial cold autoinflammatory syndrome 1 11.4
47 papular urticaria 11.4
48 chronic inducible urticaria 11.3
49 mastocytosis 11.2
50 familial cold autoinflammatory syndrome 4 11.2

Comorbidity relations with Urticaria via Phenotypic Disease Network (PDN):

Acute Cystitis Hypertension, Essential

Graphical network of the top 20 diseases related to Urticaria:

Diseases related to Urticaria

Symptoms & Phenotypes for Urticaria

UMLS symptoms related to Urticaria:

nausea and vomiting; constipation; fatigue; fever; abdominal pain; chest pain; headache; pruritus; syncope; diarrhea; edema; pain; chronic pain; sciatica; halitosis; dyspepsia; icterus; exanthema; coughing; vertigo/dizziness; symptoms; heartburn; gastrointestinal gas; pelvic pain; welts; darier's sign

Drugs & Therapeutics for Urticaria

Drugs for Urticaria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 135)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Levoleucovorin Approved, Investigational Phase 4 68538-85-2 149436
Dapsone Approved, Investigational Phase 4 80-08-0 2955
Loratadine Approved, Investigational Phase 4 79794-75-5 3957
Fexofenadine Approved, Investigational Phase 4 83799-24-0 3348
Ebastine Approved, Investigational Phase 4 90729-43-4 3191
Clevidipine Approved, Investigational Phase 4 167221-71-8
Cefadroxil Approved, Vet_approved, Withdrawn Phase 4 66592-87-8, 50370-12-2 47965 2610
Cefazolin Approved Phase 4 25953-19-9 33255 656510
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
Hydroxyzine Approved Phase 4 68-88-2 3658
Benralizumab Approved, Investigational Phase 4 1044511-01-4
Tranexamic Acid Approved Phase 4 1197-18-8 5526
Levocetirizine Approved Phase 4 130018-77-8 1549000
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
Desloratadine Approved, Investigational Phase 4 100643-71-8 124087
Cetirizine Approved Phase 4 83881-51-0 2678
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
18 Antiparasitic Agents Phase 4
19 Anti-Infective Agents Phase 4
20 Antiprotozoal Agents Phase 4
21 Antimalarials Phase 4
22 Vitamin B9 Phase 4
23 Folic Acid Antagonists Phase 4
24 Vitamin B Complex Phase 4
25 Folate Phase 4
26 Dermatologic Agents Phase 4
27 Antibodies Phase 4
28 Immunoglobulins Phase 4
29 Antibodies, Monoclonal Phase 4
30 calcium channel blockers Phase 4
31 Antibiotics, Antitubercular Phase 4
32 Clindamycin phosphate Phase 4
33 Anti-Bacterial Agents Phase 4
34 Clindamycin palmitate Phase 4
35 penicillins Phase 4
36 Immunoglobulins, Intravenous Phase 4
37 Immunoglobulin E Phase 4
38 Antifibrinolytic Agents Phase 4
39 Coagulants Phase 4
40 Hemostatics Phase 4
41 Histamine H1 Antagonists Phase 4
42 Histamine Antagonists Phase 4
43 Neurotransmitter Agents Phase 4
44 Cholinergic Agents Phase 4
45 Histamine H1 Antagonists, Non-Sedating Phase 4
Histamine Phosphate Phase 4 51-74-1 65513
47 Cholinergic Antagonists Phase 4
Budesonide Approved Phase 3 51333-22-3 63006 5281004
Promethazine Approved, Investigational Phase 3 60-87-7 4927
tannic acid Approved Phase 3 1401-55-4

Interventional clinical trials:

(show top 50) (show all 185)
# Name Status NCT ID Phase Drugs
1 A Randomized, Double-Blind, Active-Controlled, Parallel-Group Study to Compare the Efficacy and Safety of Desloratadine 5mg (Denosin®) With Levocetirizine 5mg (Xyzal®) in the Treatment of Chronic Idiopathic Urticaria Patients Unknown status NCT00346606 Phase 4 Denosin® and Xyzal®
2 A Phase IV, Randomised, Multicentre, Double-blind, Study to Evaluate the Clinical Utility of Prospective Genetic Screening (HLA-B*1301) for Susceptibility to Dapsone Hypersensitivity Syndrome Unknown status NCT02550080 Phase 4 Dapsone
3 An Exploratory Phase IV, Randomised, Double-Blind, Placebo Controlled Crossover Study to Compare the Effects of 5 mg vs. 20 mg Desloratadine on the Development of Experimentally Induced Urticaria Lesions Completed NCT00600847 Phase 4 desloratadine;desloratadine;placebo
4 Evaluation of the Inhibitory Effect of 5 Anti-Histamines in Urticaria Completed NCT01940393 Phase 4 Cetirizine;Desloratadine;Fexofenadine;Ebastine;Bilastine
5 XTEND-CIU (Xolair Treatment Efficacy of Longer Duration in Chronic Idiopathic Urticaria): A Phase IV, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Omalizumab Through 48 Weeks in Patients With Chronic Idiopathic Urticaria Completed NCT02392624 Phase 4 Omalizumab;Placebo
6 Clevidipine for Vasoreactivity Evaluation of the Pulmonary Arterial Bed (CARVE) Completed NCT01121458 Phase 4 Clevidipine
7 Postoperative Antibiotic Requirements Following Immediate Breast Reconstruction Completed NCT01244698 Phase 4 Cefadroxil discontinued early;Cefadroxil until drain removal
8 Multi-center, Double Blind, Dose Escalating Study to Compare the Effects of 5 mg, 10mg and 20mg of Desloratadine in Patients With Acquired Cold Urticaria (ACU) Completed NCT01444196 Phase 4 Desloratadine
9 Efficacy and Safety of 20 mg Levocetirizine and 15 mg Levocetirizine + 50 mg Bed-Time Hydroxyzine in Severe Chronic Urticaria in Adults: a Pilot, Randomized, Double-blind, Cross-over and Parallel, Active-controlled, Single-centre Study Completed NCT01250652 Phase 4 Levocetirizine;Levocetirizine plus Hydroxyzine
10 A Comparative Study on Clinical Efficacy and Safety of Levocetirizine 5 mg Oral Capsules Once Daily in the Morning vs. Desloratadine 5 mg Oral Capsules Once Daily in the Morning in Patients Suffering From Chronic Idiopathic Urticaria (CIU) Completed NCT00264303 Phase 4 Levocetirizine;Desloratadine
11 Role of Immunoglobulin E (IgE) Bearing Cells in Chronic Idiopathic Urticaria Completed NCT03111628 Phase 4 Omalizumab
12 A Phase IV, Multicenter, Single-arm and Open-label Study With Omalizumab (Xolair®) in Chronic Spontaneous Urticaria (CSU) Patients Who Remain Symptomatic Despite Antihistamine (H1) Treatment Completed NCT02550106 Phase 4 OMALIZUMAB
13 Effect of Omalizumab (Xolair) on the Basophil Proteome in Patients With Chronic Idiopathic Urticaria Completed NCT01701583 Phase 4 Omalizumab
14 A Pilot, Multicenter, Double-blind Randomized Study for Comparison of Aerius® "Continuous Treatment" Versus Aerius® "PRN Regimen" on Chronic Idiopathic Urticaria Patient Quality of Life Completed NCT00783354 Phase 4 desloratadine;desloratadine
15 An Open-Label Study of the Effects of Desloratadine (Aerius.) Treatment on the Quality of Life of Patients With Chronic Idiopathic Urticaria Completed NCT00795522 Phase 4 Desloratadine
16 A Comparative Double-Blind, Double- Dummy Study of Desloratadine (DL) 5 MG Once Daily, Cetirizine 10 MG Once Daily, and Placebo Once Daily in Patients With Chronic Idiopathic Urticaria (CIU) Completed NCT00751218 Phase 4 desloratadine;placebo;cetirizine
17 Effects of Bilastine on F1 Simulator Driving Performance in Patients Affected by Allergic Rhinitis and/or Urticaria Completed NCT02576041 Phase 4 Bilastine;Placebo
18 A Study of the Efficacy, Safety, and Quality of Life (QOL) in Patients With Chronic Idiopathic Urticaria Dosed With AERIUS Tablets (Desloratadine 5 mg, 10 mg, or 20 mg Once Daily) Completed NCT00536380 Phase 4 5-mg Desloratadine;10-mg Desloratadine;20-mg Desloratadine
19 Treatment of Chronic Urticarial Unresponsive to H1-antihistamines With an Anti-IL5Ralpha Monocloncal Antibody Completed NCT03183024 Phase 4
20 Comparison of Efficacy and Consistency of Action of Levocetirizine 5 mg Once Daily With Fexofenadine 60 mg Twice Daily in the Histamine Induced Wheal, Flare and Itch Response Completed NCT01586091 Phase 4 Levocetirizine Oral Tablet;Fexofenadine 60 Mg Oral Tablet;Placebo Oral Tablet
21 Efficacy and Safety of Levocetirizine Alone or in Combination With Tranexamic Acid in the Treatment of Spontaneous Chronic Urticaria. Multicentric Controlled Randomized Study in Cross-over, Double-blind Recruiting NCT03789422 Phase 4 association of levocetirizine and tranexamic acid;Levocetirizine only
22 A Randomised Controlled Trial to Evaluate the Effect of Vitamin D Supplementation in Patients With Chronic Urticaria Enrolling by invitation NCT03991845 Phase 4 Vit D
23 Molecular Endotypes of Chronic Idiopathic Urticaria Not yet recruiting NCT04774315 Phase 4 Omalizumab
24 A Comparative Double-blind, Double-dummy Study of Desloratadine (DL) 5 mg Once Daily, Cetirizine 10 mg Once Daily, and Placebo Once Daily in Patients With Chronic Idiopathic Urticaria (CIU) Terminated NCT00751166 Phase 4 Desloratadine;Cetirizine;placebo
25 Sustained Effect of Urticaria Remission With Relatively High Dose Vitamin D Supplementation After Omalizumab Discontinuation Withdrawn NCT02742805 Phase 4 Omalizumab
26 Efficacy and Safety of Omalizumab in Chronic Idiopathic Urticaria Unknown status NCT02166151 Phase 3 Omalizimab
27 High Dose Vitamin D Supplementation in Treatment of Chronic Spontaneous Urticaria Unknown status NCT02873364 Phase 3 Vitamin D3 (High dose);Vitamin D3 (Low dose)
28 An Exploratory Phase III, Randomised, Double-blind, Therapeutic Single Dose-related Effect, Parallel Group Study to Assess and Compare the Effects of 5 mg vs. 20 mg Desloratadine on Skin Lesions in Patients With Chronic Urticaria (CU) Completed NCT00598611 Phase 3 desloratadine;desloratadine
29 A Comparative Study of Efficacy and Safety of Genolar® and Xolar® in Treating Patients With Moderate to Severe Persistent Atopic Bronchial Asthma Inadequately Controlled With Stage 4 GINA (2017) Treatment Completed NCT04607629 Phase 3
30 Double-blind, Triple Cross-over, Placebo-controlled Study to Assess the Efficacy, Mechanisms, and Safety of Treatment With Bilastine 20 mg, 40 mg and 80 mg in Cold Contact Urticaria (CCU) Completed NCT01271075 Phase 2, Phase 3 Bilastine;Bilastine
31 A Phase III, Multicenter, Randomized, Double-blind, Placebo-controlled, Dose-ranging Study to Evaluate the Efficacy and Safety of Xolair® (Omalizumab) in Patients With Chronic Idiopathic Urticaria (CIU)/Chronic Spontaneous Urticaria (CSU) Who Remain Symptomatic Despite Antihistamine Treatment (H1) Completed NCT01287117 Phase 3 Omalizumab;Placebo
32 A Phase III, Multicenter, Randomized, Double-blind, Dose-ranging, Placebo-controlled Study to Evaluate the Efficacy, Response Duration and Safety of Xolair (Omalizumab) in Patients With Chronic Idiopathic Urticaria (CIU)/Chronic Spontaneous Urticaria Who Remain Symptomatic Despite Antihistamine Treatment (H1) Completed NCT01292473 Phase 3 Placebo;Omalizumab
33 Prospective Double-blind Placebo-controlled Study of the Effect of Xolair (Omalizumab) in Chronic Urticaria Patients Completed NCT01803763 Phase 2, Phase 3 Omalizumab (Xolair);Placebo
34 A Phase III, Multicenter, Randomized, Double-blind, Placebo-controlled Safety Study of Xolair (Omalizumab) in Patients With Chronic Idiopathic Urticaria (CIU) Who Remain Symptomatic Despite Treatment With H1 Antihistamines, H2 Blockers, and/or Leukotriene Receptor Antagonists Completed NCT01264939 Phase 3 Omalizumab;Placebo;H1 antihistamine, H2 antihistamine, leukotriene receptor antagonist;Diphenhydramine
35 Efficacy of Levocetirizine Fourfold Dosage in Chronic Spontaneous Urticaria Resistant to the Licensed Dosage Completed NCT02372604 Phase 3 Levocetirizine (as levocetirizine dihydrochloride), 5mg ( then 20 mg) per day . Oral administration.;Levocetirizine, (as levocetirizine dihydrochloride) 20 mg ( then 5 mg) per day. Oral administration.
36 Double-blind, Randomised, Placebo-controlled, Phase III Study Comparing the Efficacy and Safety of Bilastine 20 mg Once Daily and Levocetirizine 5 mg for the Treatment of Chronic Idiopathic Urticaria Completed NCT00421109 Phase 3 Bilastine;Levocetirizine;Placebo
37 A Multicenter, Randomized, Double-blind, Placebo-controlled Phase III Study to Evaluate the Efficacy and Safety of Omalizumab in Patients With Chronic Spontaneous Urticaria (CSU) Who Remain Symptomatic Despite H1 Antihistamine Therapy Completed NCT02329223 Phase 3
38 A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Parallel-Group Study of the Safety of Levocetirizine Dihydrochloride Oral Liquid Formulation in Children Aged 6 Months to 11 Months With Symptoms of Allergic Rhinitis or Chronic Urticaria. Completed NCT00628108 Phase 3 Levocetirizine 1.25 mg
39 A Multi-Center, Randomized, Double Blind, Placebo Controlled Parallel Group Study of the Safety of Levocetirizine Dihydrochloride Oral Liquid Formulation b.i.d Dosing in Children Aged 1 to < 6 Years Suffering From Allergic Rhinitis or Chronic Urticaria of Unknown Origin Completed NCT00619801 Phase 3 Levocetirizine;Placebo
40 Glucocorticoids Associated With Antihistamines Versus Antihistamines Randomized Double Blinded for the Management of Acute Urticaria in Emergency Completed NCT02565680 Phase 2, Phase 3 placebo;prednisone
41 A Phase III Study to Evaluate the Efficacy and Safety of Xolair® (Omalizumab) in Chinese Patients With Chronic Spontaneous Urticaria (CSU) Who Remain Symptomatic Despite Antihistamine Treatment Completed NCT03328897 Phase 3 Omalizumab;Placebo
42 Multiple-Dose Safety and Tolerance Study of Desloratadine in Atopic Pediatric Subjects and Pediatric Subjects With Chronic Idiopathic Urticaria, Ages >=2 to <12 Years, Who Are Poor Metabolizers of Desloratadine Completed NCT00757562 Phase 3 desloratadine;Placebo
43 Phase 3 Study, Exploratory, Disease Activity Controlled Dose Escalating Study to Assess the Efficacy, and Safety of Treatment With Bilastine 20 mg, 40 mg and 80 mg in Chronic Spontaneous Urticaria. Completed NCT02213367 Phase 3 Bilastine;Bilastine;Bilastin
44 A Phase III, Multi-center, Double Blind, Randomized, Active Controlled Clinical Trial to Evaluate the Non-Inferiority Comparing Cetirizine Injection 10 mg to Diphenhydramine Injection, 50 mg, for the Treatment of Acute Urticaria Completed NCT02935699 Phase 3 Test Drug (JDP-205);Active Control (Diphenhydramine)
45 An Open-Label Study of the Effects of Desloratadine Treatment on the Quality of Life of Patients With Chronic Urticaria Completed NCT00795158 Phase 3 desloratadine
46 Study of the Effects of Antipruritic Chinese Herbal Medicine on Chronic Urticaria: a Randomized, Double-blind, Placebo-controlled, Phase III Clinical Trial. Completed NCT01715740 Phase 3 Chinese Herbal Medicine (CHM);Placebo
47 A Phase III Multicentre, Parallel-group, Randomized, Placebo-controlled, Double-blind Clinical Trial to Study the Efficacy and Safety of MK-4117 in Japanese Subjects With Chronic Urticaria. Completed NCT01916967 Phase 3 Desloratadine;Placebo
48 Multicenter Pilot Phase III Clinical Trials of JDP-205 iv Injection for the Treatment of Acute Urticaria Associated With an Acute Allergic Reaction. Completed NCT02023164 Phase 3 JDP-205 Injection;Diphenhydramine
49 Randomized Clinical Trial Evaluating the Efficacy of Methotrexate in Addition to Anti-H1 Versus Placebo and Anti-H1 in the Treatment of Severe Chronic Idiopathic Urticaria Completed NCT01960283 Phase 3 Methotrexate (Novatrex ®) + anti-H1;Placebo + anti-H1
50 A Study Evaluating the Efficacy and Safety of 5 mg Levocetirizine Oral Tablets, Once Daily Versus 10 mg Loratadine Oral Tablets, Once Daily for the Treatment of Chronic Idiopathic Urticaria (CIU) Completed NCT00525382 Phase 3 levocetirizine dihydrochloride

Search NIH Clinical Center for Urticaria

Inferred drug relations via UMLS 70 / NDF-RT 51 :

Azatadine maleate
Bromodiphenhydramine hydrochloride
cetirizine hydrochloride
Chlorpheniramine Maleate
Chlorpheniramine Tannate
Cimetidine Hydrochloride
Clemastine Fumarate
Cyproheptadine hydrochloride
Dexchlorpheniramine maleate
Diphenhydramine Citrate
Diphenhydramine Hydrochloride
Fexofenadine hydrochloride
levocetirizine dihydrochloride
Methdilazine hydrochloride
Phenindamine tartrate
Pheniramine Maleate
Phenyltoloxamine citrate
trimeprazine tartrate
Tripelennamine citrate
Tripelennamine Hydrochloride

Genetic Tests for Urticaria

Genetic tests related to Urticaria:

# Genetic test Affiliating Genes
1 Urticaria (disease) 29

Anatomical Context for Urticaria

The Foundational Model of Anatomy Ontology organs/tissues related to Urticaria:

Upper Dermis

MalaCards organs/tissues related to Urticaria:

Skin, Thyroid, Endothelial, Neutrophil, Bone Marrow, T Cells, Colon

Publications for Urticaria

Articles related to Urticaria:

(show top 50) (show all 14325)
# Title Authors PMID Year
Increased total and mite-specific immunoglobulin E in patients with aspirin-induced urticaria and angioedema. 54 61
20461968 2010
Paradoxical exacerbation of chronic urticaria by H1-antihistamines and montelukast. 54 61
20128233 2009
Association of acute urticaria with Mycoplasma pneumoniae infection in hospitalized children. 61 54
19739426 2009
Simultaneous occurrence of chronic autoimmune urticaria and non-allergic asthma: a common mechanism? 61 54
19585861 2009
Comparison of the in vivo autologous skin test with in vitro diagnostic tests for diagnosis of chronic autoimmune urticaria. 61 54
19026096 2009
The A-444C polymorphism in the leukotriene C4 synthase gene is associated with aspirin-induced urticaria. 61 54
19862937 2009
Differential diagnosis of chronic urticaria. 54 61
18426134 2008
[Angioedema]. 61 54
18004529 2007
Safety of celecoxib in patients with cutaneous reactions due to ASA-NSAIDs intolerance. 54 61
17663920 2007
Natural rubber latex sensitisation and allergy in patients with spina bifida, urogenital disorders and oesophageal atresia compared with a normal paediatric population. 61 54
17638159 2007
Histamine and histamine intolerance. 54 61
17490952 2007
Safety of selective cyclooxygenase-2 inhibitors and a basic non-steroidal anti-inflammatory drug (NSAID) in Japanese patients with NSAID-induced urticaria and/or angioedema: Comparison of meloxicam, etodolac and tiaramide. 54 61
17291297 2007
Desloratadine for chronic idiopathic urticaria: a review of clinical efficacy. 54 61
17902729 2007
Cellular adhesion molecules in chronic urticaria: modulation of serum levels occurs during levocetirizine treatment. 54 61
17107400 2006
Genetic mechanism of aspirin-induced urticaria/angioedema. 54 61
16825866 2006
Use of ketoprofen oral challenges to detect cross-reactors among patients with a history of aspirin-induced urticaria. 54 61
16937749 2006
Cellular infiltrate and related cytokines, chemokines, chemokine receptors and adhesion molecules in chronic autoimmune urticaria: comparison between spontaneous and autologous serum skin test induced wheal. 54 61
17026835 2006
Patients with papular urticaria have IgG antibodies to bedbug (Cimex lectularius) antigens. 54 61
16425065 2006
HLA-DRB genotype and specific IgE responses in patients with allergies to penicillins. 54 61
16584643 2006
Monoclonal gammopathy in association with allergic disorders of the skin and respiratory tract. 54 61
16724632 2006
An unusual case of systemic mastocytosis associated with chronic lymphocytic leukaemia (SM-CLL). 54 61
16505276 2006
Pathophysiology of urticaria. 61 54
16461989 2006
Familial aggregation of aspirin-induced urticaria and leukotriene C synthase allelic variant. 61 54
16433794 2006
Eosinophil cationic protein in patients with fascioliasis: its probable effects on symptoms and signs. 54 61
16709536 2006
Angioedema. 54 61
16112343 2005
Safety of etoricoxib, a new cyclooxygenase 2 inhibitor, in patients with nonsteroidal anti-inflammatory drug-induced urticaria and angioedema. 54 61
16136765 2005
Identification of IgE-binding epitopes on gliadins for patients with food allergy to wheat. 54 61
15876313 2005
Increased responsiveness of basophils of patients with chronic urticaria to sera but hypo-responsiveness to other stimuli. 54 61
15836753 2005
COX-2 selective nonsteroidal anti-inflammatory drugs: current status. 61 54
15926604 2005
No evidence of increased serum substance P levels in chronic urticaria patients with and without demonstrable circulating vasoactive factors. 54 61
15725248 2005
Aspirin sensitivity: implications for patients with coronary artery disease. 54 61
15613671 2004
Drug-induced urticaria. 61 54
15335302 2004
Aspirin and NSAID sensitivity. 61 54
15242723 2004
Periodic fever, mild arthralgias, and reversible moderate and severe organ inflammation associated with the V198M mutation in the CIAS1 gene in three German patients--expanding phenotype of CIAS1 related autoinflammatory syndrome. 54 61
15245511 2004
Immune and histopathologic examination of flea bite-induced papular urticaria. 54 61
15104197 2004
Protein sequence analysis of a novel 103-kDa Dermatophagoides pteronyssinus mite allergen and prevalence of serum immunoglobulin E reactivity to rDer p 11 in allergic adult patients. 61 54
15005727 2004
Chronic urticaria: aetiology, management and current and future treatment options. 61 54
15516152 2004
Safety of cyclooxygenase 2 inhibitors and increased leukotriene synthesis in chronic idiopathic urticaria with sensitivity to nonsteroidal anti-inflammatory drugs. 61 54
14676074 2003
[A potential of positron emission tomography in the drug development of non-sedative antihistamines]. 61 54
14727529 2003
Exogenous oestrogen as an alternative to food allergy in the aetiology of angioneurotic oedema. 54 61
12505453 2003
Increased circulating FcepsilonRII-bearing B-lymphocytes and serum levels of IL-4 in non-autoreactive chronic idiopathic urticaria. 61 54
15719607 2003
Characterization of asparagus allergens: a relevant role of lipid transfer proteins. 54 61
12417890 2002
[Autoantibodies to thyroid gland antigens in chronic relapsing urticaria]. 61 54
12525007 2002
Mizolastine provides effective symptom relief in patients suffering from perennial allergic rhinitis: a double-blind, placebo-controlled study versus loratadine. 61 54
12269652 2002
Milk-induced urticaria is associated with the expansion of T cells expressing cutaneous lymphocyte antigen. 61 54
11941320 2002
Urticaria and angioedema induced by COX-2 inhibitors. 54 61
11842312 2002
NSAID-induced urticaria and angioedema: a reappraisal of its clinical management. 61 54
12444802 2002
Hereditary angioedema as a cause of transient abdominal pain. 61 54
11743247 2002
Urticaria and angioedema from cyclooxygenase-2 inhibitors. 54 61
11708434 2001
Tolerability to new COX-2 inhibitors in NSAID-sensitive patients with cutaneous reactions. 54 61
11570615 2001

Variations for Urticaria

ClinVar genetic disease variations for Urticaria:

# Gene Name Type Significance ClinVarId dbSNP ID Position
1 F12 , SLC34A1 NM_000505.3(F12):c.983C>G (p.Thr328Arg) SNV Pathogenic 1170 rs118204456 GRCh37: 5:176831232-176831232
GRCh38: 5:177404231-177404231
2 MEFV NM_000243.3(MEFV):c.2084A>G (p.Lys695Arg) SNV Uncertain significance 2547 rs104895094 GRCh37: 16:3293403-3293403
GRCh38: 16:3243403-3243403

Expression for Urticaria

Search GEO for disease gene expression data for Urticaria.

Pathways for Urticaria

GO Terms for Urticaria

Cellular components related to Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.56 TPT1 PTGS1 PRG2 PLCG2 HNMT FCER2
2 extracellular region GO:0005576 9.32 RNASE3 PRG2 NLRP3 IGHE FCER2 F12

Biological processes related to Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.83 RNASE3 NLRP3 IGHE F12 C1S
2 cellular oxidant detoxification GO:0098869 9.5 PTGS2 PTGS1 LTC4S
3 prostaglandin biosynthetic process GO:0001516 9.46 PTGS2 PTGS1
4 lipoxygenase pathway GO:0019372 9.4 PTGS2 LTC4S
5 peptide metabolic process GO:0006518 9.37 CPN1 CMA1
6 response to glucocorticoid GO:0051384 9.33 PTGS2 HNMT CPN1
7 cyclooxygenase pathway GO:0019371 9.26 PTGS2 PTGS1
8 inflammatory response GO:0006954 9.02 PTGS2 PTGS1 NLRP3 HRH1 ADGRE2
9 cellular response to histamine GO:0071420 8.96 HRH1 AOC1

Molecular functions related to Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 prostaglandin-endoperoxide synthase activity GO:0004666 8.62 PTGS2 PTGS1

Sources for Urticaria

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
Loading form....