Aliases & Classifications for Urticaria Pigmentosa

MalaCards integrated aliases for Urticaria Pigmentosa:

Name: Urticaria Pigmentosa 12 76 55 44 15 73
Up/mpcm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12309
ICD10 33 Q82.2
MeSH 44 D014582
NCIt 50 C3433
UMLS 73 C0042111

Summaries for Urticaria Pigmentosa

MalaCards based summary : Urticaria Pigmentosa, also known as up/mpcm, is related to mast cell disease and cutaneous mastocytosis, and has symptoms including macule and darier's sign. An important gene associated with Urticaria Pigmentosa is KIT (KIT Proto-Oncogene Receptor Tyrosine Kinase), and among its related pathways/superpathways are Signaling by GPCR and NF-kappaB Signaling. Affiliated tissues include skin, bone and bone marrow.

Wikipedia : 76 Urticaria pigmentosa (also known as generalized eruption of cutaneous mastocytosis (childhood type) ) is... more...

Related Diseases for Urticaria Pigmentosa

Diseases related to Urticaria Pigmentosa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 mast cell disease 32.6 KIT KITLG
2 cutaneous mastocytosis 32.0 CMA1 KIT KITLG
3 systemic mastocytosis 30.9 KIT KITLG
4 indolent systemic mastocytosis 30.5 KIT KITLG
5 mast-cell leukemia 30.2 KIT KITLG
6 neurofibroma 30.0 KIT KITLG
7 mast cell neoplasm 29.7 CMA1 KIT KITLG
8 asthma 26.8 CALCA IL2RA KITLG TAC1 VIP
9 nodular urticaria pigmentosa 12.1
10 maculopapular cutaneous mastocytosis 12.0
11 plaque-form urticaria pigmentosa 12.0
12 typical urticaria pigmentosa 12.0
13 urticaria 11.1
14 monoclonal mast cell activation syndrome 11.0
15 aggressive systemic mastocytosis 10.4 KIT KITLG
16 ewing's family of tumors 10.4 KIT KITLG
17 dowling-degos disease 1 10.3 KIT KITLG
18 piebald trait 10.3 KIT KITLG
19 vernal conjunctivitis 10.2 CMA1 IL2RA
20 clear cell acanthoma 10.2 IL2RA KITLG
21 leukocyte disease 10.2 KIT KITLG
22 aging 10.1
23 leukemia 10.1
24 telangiectasia macularis eruptive perstans 10.1
25 telangiectasia macularis eruptiva perstans 10.1
26 extragonadal seminoma 10.1 CALCA KIT
27 burn scar 10.1 CALCA TAC1
28 somatoform disorder 10.1 IL2RA TAC1
29 osteoporosis 10.0
30 juvenile xanthogranuloma 10.0
31 autonomic nervous system disease 10.0 CALCA TAC1
32 cutaneous solitary mastocytoma 10.0 CMA1 KIT KITLG
33 brachial plexus lesion 10.0 CALCA TAC1
34 complex regional pain syndrome 10.0 CALCA TAC1
35 gastroesophageal reflux 9.9
36 lentigines 9.9
37 leukemia, acute lymphoblastic 9.9
38 lymphoblastic leukemia 9.9
39 syringoma 9.9
40 dermatitis 9.9
41 scabies 9.9
42 testicular germ cell tumor 9.9 KIT KITLG
43 small cell carcinoma 9.9 CALCA KIT
44 hemiplegia 9.8 CALCA TAC1
45 anismus 9.8 TAC1 VIP
46 achalasia 9.8 KIT VIP
47 acanthosis nigricans 9.8
48 leopard syndrome 1 9.8
49 acrofacial dysostosis 1, nager type 9.8
50 celiac disease 1 9.8

Graphical network of the top 20 diseases related to Urticaria Pigmentosa:



Diseases related to Urticaria Pigmentosa

Symptoms & Phenotypes for Urticaria Pigmentosa

UMLS symptoms related to Urticaria Pigmentosa:


macule, darier's sign

Drugs & Therapeutics for Urticaria Pigmentosa

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Ultraviolet (UVA and UVB) Light Therapy in the Treatment of Inflammatory Skin Conditions Terminated NCT00129415 Phase 1, Phase 2
2 Natural History of Urticaria Pigmentosa in Children Completed NCT00467792
3 Cytokine Production Patterns in Patients With Systemic Mastocytosis Compared With Atopic Dermatitis and Healthy Individuals Completed NCT00001760
4 Cause and Natural Course of Pediatric-Onset Mastocytosis Completed NCT00050193
5 Cutaneous Mastocytosis in Children: Analysis of Somatic and Germline Mutations Recruiting NCT02761473
6 Study of Factors Regulating Mast Cell Proliferation Recruiting NCT00044122
7 Mast Cell Connect: A Registry for Patients With Mastocytosis Recruiting NCT02620254

Search NIH Clinical Center for Urticaria Pigmentosa

Cochrane evidence based reviews: urticaria pigmentosa

Genetic Tests for Urticaria Pigmentosa

Anatomical Context for Urticaria Pigmentosa

MalaCards organs/tissues related to Urticaria Pigmentosa:

41
Skin, Bone, Bone Marrow, Monocytes, Testes, Thyroid, Smooth Muscle

Publications for Urticaria Pigmentosa

Articles related to Urticaria Pigmentosa:

(show top 50) (show all 378)
# Title Authors Year
1
Urticaria Pigmentosa (Cutaneous Mastocytosis) ( 29494109 )
2018
2
Coexistence of urticaria pigmentosa and thalassemia minor in a young adult. ( 29785323 )
2018
3
Longitudinal Study of Pediatric Urticaria Pigmentosa. ( 28133781 )
2017
4
Testicular Cancer in Monozygotic Twin Brothers with Urticaria Pigmentosa. ( 29230478 )
2017
5
Urticaria pigmentosa with concomitant polycythaemia vera in a 3-year-old boy. ( 28614617 )
2017
6
Urticaria Pigmentosa Mimicking Multiple Lentigine-like Brownish Macules in a 22-Month-Old Boy. ( 28480643 )
2017
7
General Anesthesia in a Patient With Urticaria Pigmentosa Referred for Electroconvulsive Therapy. ( 26934274 )
2016
8
Sustained improvement in urticaria pigmentosa and pruritus in a case of indolent systemic mastocytosis treated with cladribine. ( 25515765 )
2015
9
Urticaria pigmentosa-like disease in a dog. ( 25750443 )
2015
10
Urticaria pigmentosa masquerading as non-accidental injury. ( 25784750 )
2015
11
NKp46 regulates the production of serine proteases and IL-22 in human mast cells in urticaria pigmentosa. ( 25940096 )
2015
12
Urticaria pigmentosa. ( 26752589 )
2015
13
Urticaria pigmentosa complicated with esophageal eosinophilia. ( 25437994 )
2014
14
Telangiectasia macularis eruptiva perstans or highly vascularized urticaria pigmentosa? ( 25439382 )
2014
15
A 1-year-old boy with persistent, generalized eruption. Urticaria pigmentosa. ( 24549082 )
2014
16
A segmental rash in a young male: a quiz. Naevoid urticaria pigmentosa. ( 23828224 )
2014
17
Response of urticaria pigmentosa to cladribine in a patient with systemic mastocytosis. ( 23205635 )
2013
18
Dermatoscopic findings of urticaria pigmentosa. ( 24474113 )
2013
19
Familial urticaria pigmentosa: report of a family and review of the role of KIT mutations. ( 22892471 )
2013
20
Cutaneous mastocytosis: a case of bullous urticaria pigmentosa. ( 23513553 )
2013
21
Urticaria pigmentosa in a female patient with celiac disease: response to a gluten-free diet. ( 22465751 )
2013
22
Acute interstitial nephritis secondary to long-term use of cetirizine for the treatment of urticaria pigmentosa. ( 23083330 )
2013
23
Nevoid urticaria pigmentosa along Blaschko's line. ( 22221017 )
2012
24
Dermatophytosis and papular eosinophilic/mastocytic dermatitis (urticaria pigmentosa-like dermatitis) in three Devon Rex cats. ( 22736683 )
2012
25
Urticaria pigmentosa after treatment with TNF antagonists: a case report. ( 22184778 )
2011
26
Cutaneous mastocytosis in twins: multiple mastocytomas and urticaria pigmentosa in two pairs of monozygotic twins. ( 21385209 )
2011
27
Gastroesophageal reflux disease accompanying urticaria pigmentosa. ( 22185927 )
2011
28
Megalocornea-urticaria pigmentosa syndrome--a new syndrome? ( 19706342 )
2009
29
[Urticaria pigmentosa: a current approach]. ( 19768974 )
2009
30
Generalized brownish macules in infancy. Urticaria pigmentosa. ( 19873965 )
2009
31
Urticaria pigmentosa associated with acute stress and lesional skin mast-cell expression of CRF-R1. ( 19094125 )
2009
32
Picture of the month. Urticaria pigmentosa. ( 18391148 )
2008
33
CD25 expression on cutaneous mast cells from adult patients presenting with urticaria pigmentosa is predictive of systemic mastocytosis. ( 18162781 )
2008
34
Mastocytosis with urticaria pigmentosa and osteoporosis. ( 19061601 )
2008
35
What is your diagnosis? Cutaneous mastocytosis (urticaria pigmentosa). ( 18543588 )
2008
36
Urticaria pigmentosa. A case report. ( 18709295 )
2008
37
Unusual cutaneous findings of urticaria pigmentosa and telangiectasia macularis eruptiva perstans associated with marked myelofibrosis. ( 17040445 )
2006
38
Urticaria pigmentosa and mastocytosis: the role of immunophenotyping in diagnosis and determining response to treatment. ( 16822380 )
2006
39
Anesthetic management of a labouring parturient with urticaria pigmentosa. ( 16575037 )
2006
40
The cosmetic treatment of urticaria pigmentosa with Nd:YAG laser at 532 nanometers. ( 17166203 )
2005
41
Intertriginous urticaria pigmentosa. ( 15604555 )
2005
42
Nodular scabies mimicking urticaria pigmentosa in an infant. ( 16045712 )
2005
43
Urticaria pigmentosa. ( 15120152 )
2004
44
Localized urticaria pigmentosa triggered by mesotherapy. ( 15539904 )
2004
45
Papular eosinophilic/mastocytic dermatitis (feline urticaria pigmentosa) in Devon Rex cats: A distinct disease entity or a histopathological reaction pattern? ( 15305933 )
2004
46
Evolution of urticaria pigmentosa into indolent systemic mastocytosis: abnormal immunophenotype of mast cells without evidence of c-kit mutation ASP-816-VAL. ( 12688351 )
2003
47
Familial urticaria pigmentosa associated with thrombocytosis as the initial symptom of systemic mastocytosis and Down's syndrome. ( 14761147 )
2003
48
Medium- versus high-dose ultraviolet A1 therapy for urticaria pigmentosa: a pilot study. ( 14512916 )
2003
49
Anaphylaxis to insect sting associated with urticaria pigmentosa. ( 12866320 )
2003
50
Severe pruritus in a patient with urticaria pigmentosa treated with topical 5% urea and 3% polidocanol cream. ( 14522633 )
2003

Variations for Urticaria Pigmentosa

Expression for Urticaria Pigmentosa

Search GEO for disease gene expression data for Urticaria Pigmentosa.

Pathways for Urticaria Pigmentosa

GO Terms for Urticaria Pigmentosa

Cellular components related to Urticaria Pigmentosa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 CALCA CMA1 KITLG TAC1 VIP
2 extracellular space GO:0005615 9.02 CALCA CMA1 KIT KITLG TAC1

Biological processes related to Urticaria Pigmentosa according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.69 CALCA KITLG VIP
2 MAPK cascade GO:0000165 9.54 IL2RA KIT KITLG
3 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.49 CALCA VIP
4 regulation of blood pressure GO:0008217 9.48 CALCA TAC1
5 positive regulation of MAP kinase activity GO:0043406 9.46 KIT KITLG
6 ovarian follicle development GO:0001541 9.43 KIT KITLG
7 cellular response to nerve growth factor stimulus GO:1990090 9.4 CALCA TAC1
8 response to pain GO:0048265 9.32 CALCA TAC1
9 embryonic hemopoiesis GO:0035162 9.26 KIT KITLG
10 inflammatory response GO:0006954 9.26 CALCA IL2RA KIT TAC1
11 positive regulation of ossification GO:0045778 9.16 CALCA TAC1
12 ectopic germ cell programmed cell death GO:0035234 8.62 KIT KITLG

Molecular functions related to Urticaria Pigmentosa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.96 KIT KITLG
2 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.8 IL2RA KIT KITLG

Sources for Urticaria Pigmentosa

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