MCID: UTR030
MIFTS: 25

Uterine Adnexa Cancer

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Uterine Adnexa Cancer

MalaCards integrated aliases for Uterine Adnexa Cancer:

Name: Uterine Adnexa Cancer 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:11747
ICD9CM 34 183 183.9
SNOMED-CT 67 94126000
ICD10 32 C57.4
UMLS 71 C0153577 C0153584

Summaries for Uterine Adnexa Cancer

Disease Ontology : 12 A uterine cancer that is located in the adnexa.

MalaCards based summary : Uterine Adnexa Cancer is related to broad ligament malignant neoplasm and parametrium malignant neoplasm. An important gene associated with Uterine Adnexa Cancer is SKA3 (Spindle And Kinetochore Associated Complex Subunit 3), and among its related pathways/superpathways are Pathways in cancer and Apoptosis Modulation and Signaling. Affiliated tissues include adnexa, and related phenotypes are Increased cell death HMECs cells and cellular

Related Diseases for Uterine Adnexa Cancer

Diseases related to Uterine Adnexa Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 broad ligament malignant neoplasm 11.4
2 parametrium malignant neoplasm 11.4
3 round ligament malignant neoplasm 11.4
4 splenic diffuse red pulp small b-cell lymphoma 10.1 TP53 NOTCH1
5 vulvar intraepithelial neoplasia 10.1 TP53 BIRC5
6 adult liposarcoma 10.1 NOTCH1 MDM2
7 rothmund-thomson syndrome, type 2 10.0 TP53 RECQL4 PIF1
8 ring chromosome 7 10.0 TP53 MDM2
9 actinic cheilitis 10.0 TP53 MDM2
10 esophagus verrucous carcinoma 10.0 TP53 MDM2
11 invasive bladder transitional cell carcinoma 10.0 TP53 NOTCH1
12 bone giant cell sarcoma 10.0 TP53 MDM2
13 maxillary sinus adenocarcinoma 10.0 TP53 MDM2
14 soft tissue sarcoma 9.9 TP53 MDM2
15 adult malignant schwannoma 9.9 TP53 FOXM1 BIRC5
16 embryonal sarcoma 9.9 TP53 MDM2
17 dedifferentiated liposarcoma 9.8 TP53 MDM2
18 familial retinoblastoma 9.8 TP53 RECQL4 MDM2
19 rare head and neck tumor 9.8 TP53 PIK3CA
20 breast squamous cell carcinoma 9.8 TP53 PIK3CA
21 rare adenocarcinoma of the breast 9.8 TP53 PIK3CA
22 bladder transitional cell papilloma 9.7 TP53 BIRC5
23 adult hepatocellular carcinoma 9.7 TP53 PIK3CA
24 adenosquamous lung carcinoma 9.7 PIK3CA BIRC5
25 grade iii astrocytoma 9.7 TP53 MDM2 FOXM1
26 undifferentiated pleomorphic sarcoma 9.7 RECQL4 PIK3CA
27 breast sarcoma 9.6 TP53 PIK3CA
28 inflammatory myofibroblastic tumor 9.6 TP53 MDM2 BIRC5
29 oropharynx cancer 9.5 TP53 PIK3CA NOTCH1
30 wilms tumor 1 9.5 TP53 NOTCH1 BIRC5 BCLAF1
31 pre-malignant neoplasm 9.5 TP53 PIK3CA NOTCH1
32 serous cystadenocarcinoma 9.4 TP53 PIK3CA BIRC5
33 parameningeal embryonal rhabdomyosarcoma 9.4 TP53 PIK3CA MDM2
34 cystadenocarcinoma 9.4 TP53 PIK3CA BIRC5
35 anal squamous cell carcinoma 9.4 TP53 PIK3CA MDM2
36 ovarian carcinosarcoma 9.4 TP53 PIK3CA
37 ovary adenocarcinoma 9.4 TP53 PIK3CA MDM2
38 liposarcoma 9.3 TP53 PIK3CA MDM2
39 clear cell renal cell carcinoma 9.3 TP53 NOTCH1 MDM2 BIRC5
40 thyroid gland anaplastic carcinoma 9.2 TP53 PIK3CA
41 ovarian serous cystadenocarcinoma 9.2 TP53 PIK3CA BIRC5
42 suppression of tumorigenicity 12 9.1 TP53 PIK3CA NOTCH1 MDM2
43 mantle cell lymphoma 9.1 TP53 PIK3CA NOTCH1 MDM2
44 bladder urothelial carcinoma 9.0 TP53 PIK3CA MDM2 BIRC5
45 adenoid cystic carcinoma 8.9 TP53 PIK3CA NOTCH1 MDM2
46 lymphoma, non-hodgkin, familial 8.7 TP53 PIK3CA NOTCH1 MDM2 BIRC5
47 pancreatic adenocarcinoma 8.7 TP53 PIK3CA NOTCH1 MDM2 BIRC5
48 glioblastoma multiforme 8.6 TP53 PIK3CA NOTCH1 MDM2 FOXM1 BIRC5
49 lung cancer susceptibility 3 8.6 TP53 PIK3CA NOTCH1 MDM2 FOXM1 BIRC5
50 brain cancer 8.6 TP53 PIK3CA NOTCH1 MDM2 MAGEC1 BIRC5

Graphical network of the top 20 diseases related to Uterine Adnexa Cancer:



Diseases related to Uterine Adnexa Cancer

Symptoms & Phenotypes for Uterine Adnexa Cancer

GenomeRNAi Phenotypes related to Uterine Adnexa Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death HMECs cells GR00103-A-0 9.23 BIRC5 MDM2 NEK1 NEK9 PIK3CA TP53

MGI Mouse Phenotypes related to Uterine Adnexa Cancer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.03 ASPM BCLAF1 BIRC5 FOXM1 MDM2 NOTCH1
2 endocrine/exocrine gland MP:0005379 9.85 ASPM BIRC5 FOXM1 MDM2 NEK1 NOTCH1
3 homeostasis/metabolism MP:0005376 9.77 ASPM BCLAF1 BIRC5 CLCNKA FOXM1 IRF5
4 immune system MP:0005387 9.4 ASPM BCLAF1 BIRC5 FOXM1 IRF5 MDM2

Drugs & Therapeutics for Uterine Adnexa Cancer

Search Clinical Trials , NIH Clinical Center for Uterine Adnexa Cancer

Genetic Tests for Uterine Adnexa Cancer

Anatomical Context for Uterine Adnexa Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Uterine Adnexa Cancer:

19
Adnexa

Publications for Uterine Adnexa Cancer

Variations for Uterine Adnexa Cancer

Expression for Uterine Adnexa Cancer

Search GEO for disease gene expression data for Uterine Adnexa Cancer.

Pathways for Uterine Adnexa Cancer

Pathways related to Uterine Adnexa Cancer according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1 12.6 TP53 PIK3CA NOTCH1 MDM2 BIRC5
2
Show member pathways
12.56 TP53 PIK3CA MDM2 IRF5 BIRC5
3
Show member pathways
12.12 TP53 PIK3CA MDM2 BIRC5
4 11.83 TP53 PIK3CA MDM2 FOXM1
5 11.7 TP53 MDM2 IRF5
6 11.63 TP53 PIK3CA NOTCH1 MDM2
7 11.57 UBE2S TP53 RECQL4 MDM2 FOXM1 CDCA2
8 11.4 TP53 PIK3CA NOTCH1
9 11.28 TP53 PIK3CA MDM2
10 11.12 TP53 PIK3CA MDM2 BIRC5
11 10.82 TP53 MDM2 BIRC5

GO Terms for Uterine Adnexa Cancer

Cellular components related to Uterine Adnexa Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10 UBE2K TP53 SNCA RECQL4 PIF1 NOTCH1
2 cytoplasm GO:0005737 9.8 UBE2K TP53 SNCA SKA3 RECQL4 PIK3CA
3 cytosol GO:0005829 9.44 UBE2S UBE2K TP53 SNCA SKA3 PIK3CA

Biological processes related to Uterine Adnexa Cancer according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.88 TP53 PIK3CA IRF5 BIRC5
2 positive regulation of apoptotic process GO:0043065 9.8 TP53 SNCA NOTCH1 IRF5 BCLAF1
3 negative regulation of transcription, DNA-templated GO:0045892 9.8 TP53 NOTCH1 MDM2 FOXM1 BIRC5 BCLAF1
4 chromosome segregation GO:0007059 9.73 SKA3 CDCA2 BIRC5
5 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.67 SNCA MDM2 BIRC5
6 negative regulation of anoikis GO:2000811 9.58 PIK3CA NOTCH1
7 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.57 TP53 FOXM1
8 response to magnesium ion GO:0032026 9.55 SNCA MDM2
9 atrioventricular valve morphogenesis GO:0003181 9.54 NOTCH1 MDM2
10 response to muramyl dipeptide GO:0032495 9.52 NOTCH1 IRF5
11 negative regulation of telomerase activity GO:0051974 9.51 TP53 PIF1
12 cell division GO:0051301 9.5 UBE2S SKA3 NEK9 NEK1 CDCA2 BIRC5
13 DNA strand renaturation GO:0000733 9.48 TP53 RECQL4
14 cellular response to UV-C GO:0071494 9.46 TP53 MDM2
15 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.43 TP53 NOTCH1
16 free ubiquitin chain polymerization GO:0010994 9.37 UBE2S UBE2K
17 cardiac septum morphogenesis GO:0060411 9.33 TP53 NOTCH1 MDM2
18 cell cycle GO:0007049 9.28 UBE2S TP53 SKA3 NEK9 NEK1 FOXM1
19 cellular response to actinomycin D GO:0072717 9.26 TP53 MDM2

Molecular functions related to Uterine Adnexa Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.09 UBE2S UBE2K TP53 SNCA SKA3 RECQL4
2 ATP binding GO:0005524 9.56 UBE2S UBE2K TP53 RECQL4 PIK3CA PIF1
3 enzyme binding GO:0019899 9.02 TP53 SNCA NOTCH1 MDM2 BIRC5

Sources for Uterine Adnexa Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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