MCID: UTR030
MIFTS: 21

Uterine Adnexa Cancer

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Uterine Adnexa Cancer

MalaCards integrated aliases for Uterine Adnexa Cancer:

Name: Uterine Adnexa Cancer 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:11747
ICD9CM 34 183 183.9
SNOMED-CT 67 188201008 94126000
ICD10 32 C57.4
UMLS 71 C0153577 C0153584

Summaries for Uterine Adnexa Cancer

Disease Ontology : 12 A uterine cancer that is located in the adnexa.

MalaCards based summary : Uterine Adnexa Cancer is related to broad ligament malignant neoplasm and parametrium malignant neoplasm. An important gene associated with Uterine Adnexa Cancer is SKA3 (Spindle And Kinetochore Associated Complex Subunit 3), and among its related pathways/superpathways is DNA Damage. Affiliated tissues include adnexa, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Uterine Adnexa Cancer

Graphical network of the top 20 diseases related to Uterine Adnexa Cancer:



Diseases related to Uterine Adnexa Cancer

Symptoms & Phenotypes for Uterine Adnexa Cancer

GenomeRNAi Phenotypes related to Uterine Adnexa Cancer according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.58 NOTCH1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.58 FOXM1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-139 9.58 NOTCH1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-142 9.58 BCLAF1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.58 NOTCH1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.58 NOTCH1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-167 9.58 FOXM1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-175 9.58 BCLAF1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-180 9.58 FOXM1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.58 FOXM1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.58 FOXM1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-28 9.58 NOTCH1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.58 FOXM1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.58 FOXM1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.58 BCLAF1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.58 BCLAF1 FOXM1 NOTCH1

MGI Mouse Phenotypes related to Uterine Adnexa Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.56 ASPM BIRC5 CLCNKA FOXM1 NEK1 NOTCH1
2 hematopoietic system MP:0005397 9.32 ASPM BCLAF1 BIRC5 CLCNKA IRF5 NEK1

Drugs & Therapeutics for Uterine Adnexa Cancer

Search Clinical Trials , NIH Clinical Center for Uterine Adnexa Cancer

Genetic Tests for Uterine Adnexa Cancer

Anatomical Context for Uterine Adnexa Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Uterine Adnexa Cancer:

19
Adnexa

Publications for Uterine Adnexa Cancer

Variations for Uterine Adnexa Cancer

Expression for Uterine Adnexa Cancer

Search GEO for disease gene expression data for Uterine Adnexa Cancer.

Pathways for Uterine Adnexa Cancer

Pathways related to Uterine Adnexa Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.49 UBE2S TP53 RECQL4 FOXM1 CDCA2

GO Terms for Uterine Adnexa Cancer

Cellular components related to Uterine Adnexa Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.47 UBE2S UBE2K TP53 RECQL4 PIF1 NOTCH1
2 centrosome GO:0005813 9.35 TP53 SKA3 NEK9 NEK1 ASPM

Biological processes related to Uterine Adnexa Cancer according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.83 TP53 NOTCH1 IRF5 BCLAF1
2 negative regulation of transcription, DNA-templated GO:0045892 9.83 TP53 NOTCH1 FOXM1 BIRC5 BCLAF1
3 regulation of cell cycle GO:0051726 9.72 TP53 FOXM1 BIRC5
4 chromosome segregation GO:0007059 9.58 SKA3 CDCA2 BIRC5
5 positive regulation of neuroblast proliferation GO:0002052 9.54 NOTCH1 ASPM
6 neuronal stem cell population maintenance GO:0097150 9.51 NOTCH1 ASPM
7 cell division GO:0051301 9.5 UBE2S SKA3 NEK9 NEK1 CDCA2 BIRC5
8 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.49 TP53 FOXM1
9 cardiac septum morphogenesis GO:0060411 9.48 TP53 NOTCH1
10 negative regulation of telomerase activity GO:0051974 9.46 TP53 PIF1
11 response to muramyl dipeptide GO:0032495 9.37 NOTCH1 IRF5
12 DNA strand renaturation GO:0000733 9.32 TP53 RECQL4
13 cell cycle GO:0007049 9.28 UBE2S TP53 SKA3 NEK9 NEK1 FOXM1
14 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.26 TP53 NOTCH1
15 free ubiquitin chain polymerization GO:0010994 9.16 UBE2S UBE2K

Molecular functions related to Uterine Adnexa Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.17 UBE2S UBE2K TP53 RECQL4 PIF1 NEK9

Sources for Uterine Adnexa Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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