Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: UTR058
MIFTS: 54

Uterine Anomalies

Categories: Reproductive diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Uterine Anomalies

About this section

MalaCards integrated aliases for Uterine Anomalies:

Name: Uterine Anomalies 57
Uterine Diseases 55 43 44 73
Uterine Disease 12 15
Uterine Abnormality 55

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
uterine anomalies:
Inheritance autosomal dominant inheritance


Classifications:

MalaCards categories:
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

OMIM 57 192000
Disease Ontology 12 DOID:345
ICD10 33 N85.9
ICD9CM 35 621.9
MeSH 44 D014591
NCIt 50 C26907
SNOMED-CT 68 12337004
MedGen 42 C0266383
SNOMED-CT via HPO 69 263681008 31401003
UMLS 73 C0042131
Sources

Summaries for Uterine Anomalies

About this section
MedlinePlus : 43 The uterus, or womb, is the place where a baby grows when a woman is pregnant. The first sign of a problem with the uterus may be bleeding between periods or after sex. Causes can include hormones, thyroid problems, fibroids, polyps, cancer, infection, or pregnancy. Treatment depends on the cause. Sometimes birth control pills treat hormonal imbalances. If a thyroid problem is the cause, treating it may also stop the bleeding. If you have cancer or hyperplasia, an overgrowth of normal cells in the uterus, you may need surgery. With two other uterine problems, tissue that normally lines the uterus grows where it is not supposed to. In endometriosis, it grows outside the uterus. In adenomyosis, it grows in the uterus's outside walls. Pain medicine may help. Other treatments include hormones and surgery.

MalaCards based summary : Uterine Anomalies, also known as uterine diseases, is related to adenomyosis and endometrial disease, and has symptoms including pelvic pain An important gene associated with Uterine Anomalies is CYP19A1 (Cytochrome P450 Family 19 Subfamily A Member 1), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Heparin and Enoxaparin have been mentioned in the context of this disorder. Affiliated tissues include uterus, thyroid and cervix, and related phenotypes are bicornuate uterus and Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)

Disease Ontology : 12 A female reproductive system disease that is located in the uterus.

Description from OMIM: 192000
Sources

Related Diseases for Uterine Anomalies

About this section

Diseases in the Uterine Anomalies family:

Uterine Inflammatory Disease

Diseases related to Uterine Anomalies via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 182)
# Related Disease Score Top Affiliating Genes
1 adenomyosis 32.3 CYP19A1 ESR1 PGR
2 endometrial disease 31.8 CYP19A1 ESR1 OXT
3 placenta disease 31.7 TLR9 OXT CSH2 CSH1
4 cervix disease 31.2 ZNF84 TP53 TLR9 PTPRN MAPK8IP2 MAPK8IP1
5 endometriosis 30.1 CYP19A1 ESR1 PGR PTEN
6 hemometra 30.1 MAPK8IP1 OXT PTPRN
7 endometritis 29.9 ESR1 OXT PGR
8 endometrial cancer 29.7 TP53 PTEN PGR MSH2 MLH1 ESR1
9 acrorenal-mandibular syndrome 11.0
10 pyometritis 10.8
11 female infertility of uterine origin 10.8
12 uterine inflammatory disease 10.8
13 chronic subinvolution of uterus 10.8
14 adhesions of uterus 10.8
15 uterine inversion 10.8
16 vestibular gland benign neoplasm 10.4 ESR1 PGR
17 bartholin's gland adenoma 10.4 ESR1 PGR
18 endometrium carcinoma in situ 10.4 PGR TP53
19 vulvar syringoma 10.4 ESR1 PGR
20 breast duct papilloma 10.4 PGR PTEN
21 glassy cell carcinoma of the cervix 10.4 ESR1 PGR
22 early invasive cervical adenocarcinoma 10.4 CDKN2A INSM1
23 progesterone-receptor positive breast cancer 10.4 PGR ESR1 CYP19A1
24 microinvasive cervical squamous cell carcinoma 10.4 INSM1 PTPRN
25 gender identity disorder 10.4 PGR ESR1 CYP19A1
26 lung leiomyoma 10.4 ESR1 PGR
27 carcinosarcoma 10.4 PGR PTEN TP53
28 estrogen excess 10.4 CYP19A1 ESR1 PGR
29 mammographic density 10.4 CYP19A1 ESR1 PGR
30 endocervical carcinoma 10.4 MAPK8IP1 ESR1 CDKN2A
31 vulvar benign neoplasm 10.4 ESR1 PGR
32 bartholin's gland benign neoplasm 10.4 PGR ESR1 CDKN2A
33 trigonitis 10.4 ESR1 PGR
34 endometrial squamous cell carcinoma 10.4 PGR ESR1 CDKN2A
35 vulvar leiomyoma 10.4 ESR1 PGR
36 adenoid basal cell carcinoma 10.4 PGR ESR1 CDKN2A
37 endometrial mucinous adenocarcinoma 10.4 PGR ESR1 CDKN2A
38 small cell carcinoma 10.4 CDKN2A PTEN TP53
39 adenosarcoma 10.4 ESR1 PGR TP53
40 prostatic hypertrophy 10.4 CYP19A1 ESR1 PGR
41 testicular trophoblastic tumor 10.4 CSH1 CSH2
42 breast benign neoplasm 10.4 ESR1 PGR TP53
43 thoracic benign neoplasm 10.4 ESR1 PGR TP53
44 uterine corpus cancer 10.4 ESR1 PGR TP53
45 uterine benign neoplasm 10.4 ESR1 PGR TLR9
46 bartholin's gland disease 10.4 TP53 PGR CDKN2A
47 sebaceous adenoma 10.4 MSH2 MLH1 ESR1
48 tongue disease 10.4 CDKN2A TLR9 TP53
49 breast fibroadenoma 10.4 CYP19A1 ESR1 PGR
50 anal squamous cell carcinoma 10.4 MLH1 CDKN2A TP53

Graphical network of the top 20 diseases related to Uterine Anomalies:



Diseases related to Uterine Anomalies
Sources

Symptoms & Phenotypes for Uterine Anomalies

About this section

Symptoms via clinical synopsis from OMIM:

57
G U:
uterine anomalies
uterus arcuatus
uterus bicornis unicollis


Clinical features from OMIM:

192000

Human phenotypes related to Uterine Anomalies:

32
# Description HPO Frequency HPO Source Accession
1 bicornuate uterus 32 HP:0000813

UMLS symptoms related to Uterine Anomalies:


pelvic pain

GenomeRNAi Phenotypes related to Uterine Anomalies according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 8.92 ESR1 MSH2 PTEN PTPRN

MGI Mouse Phenotypes related to Uterine Anomalies:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.36 AREG CDKN2A CYP19A1 ESR1 GP5 HNF1B
2 endocrine/exocrine gland MP:0005379 10.32 AREG CDKN2A CYP19A1 ESR1 HNF1B INSM1
3 cellular MP:0005384 10.25 CDKN2A CYP19A1 ESR1 INSM1 MAPK8IP1 MLH1
4 digestive/alimentary MP:0005381 10.24 AREG CDKN2A CYP19A1 ESR1 INSM1 MLH1
5 immune system MP:0005387 10.18 AREG CDKN2A CYP19A1 ESR1 HNF1B MLH1
6 hematopoietic system MP:0005397 10.16 AREG CDKN2A CYP19A1 ESR1 MLH1 MSH2
7 mortality/aging MP:0010768 10.1 AREG CDKN2A ESR1 HNF1B INSM1 MAPK8IP1
8 integument MP:0010771 10.07 AREG CDKN2A CYP19A1 ESR1 MLH1 MSH2
9 liver/biliary system MP:0005370 9.87 CDKN2A CYP19A1 ESR1 HNF1B MAPK8IP1 PTEN
10 neoplasm MP:0002006 9.7 CDKN2A ESR1 MLH1 MSH2 PGR PTEN
11 renal/urinary system MP:0005367 9.5 CYP19A1 ESR1 HNF1B OXT PTEN TLR9
12 reproductive system MP:0005389 9.36 AREG CDKN2A CYP19A1 ESR1 MAPK8IP1 MAPK8IP2
Sources

Drugs & Therapeutics for Uterine Anomalies

About this section

Drugs for Uterine Anomalies (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 74)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
2
Enoxaparin Approved Phase 4 9005-49-6 772
3
Dalteparin Approved Phase 4 9005-49-6
4
leucovorin Approved Phase 4 58-05-9 6006 143
5
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
7 Immunologic Factors Phase 4,Not Applicable
8 Estrogen Antagonists Phase 4,Phase 3
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
10 Estrogens Phase 4,Phase 3
11 Hormones Phase 4,Phase 3
12 Hormone Antagonists Phase 4,Phase 3
13 Estrogen Receptor Antagonists Phase 4,Phase 3
14 Antibodies, Antiphospholipid Phase 4
15 Vitamins Phase 4
16 calcium heparin Phase 4
17 Vitamin B9 Phase 4
18 Vitamin B Complex Phase 4
19 Anticoagulants Phase 4
20 Folate Phase 4
21 Antibodies Phase 4
22 Hematinics Phase 4
23 Heparin, Low-Molecular-Weight Phase 4
24 Fibrinolytic Agents Phase 4
25 Trace Elements Phase 4
26 Immunoglobulins Phase 4
27 Micronutrients Phase 4
28 17-alpha-hydroxy-progesterone caproate Phase 4
29 Caproate Phase 4
30 11-hydroxyprogesterone Phase 4
31 Progestins Phase 4
32
Buserelin Approved, Investigational Phase 3 57982-77-1
33
Ganirelix Approved Phase 3 123246-29-7, 124904-93-4 25081094
34
Cetrorelix Approved, Investigational Phase 3 120287-85-6 16129715 25074887
35
Tamoxifen Approved Phase 3 10540-29-1 2733526
36 Deslorelin Investigational, Vet_approved Phase 3 57773-65-6
37
Afimoxifene Investigational Phase 3 68392-35-8
38 Triptorelin Pamoate Phase 3
39 Contraceptive Agents Phase 3
40 Antineoplastic Agents, Hormonal Phase 3
41 Luteolytic Agents Phase 3
42 Fertility Agents Phase 3
43 Estrogen Receptor Modulators Phase 3
44 Selective Estrogen Receptor Modulators Phase 3
45 Bone Density Conservation Agents Phase 3
46
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
47
Ofloxacin Approved Phase 2 82419-36-1 4583
48
Levofloxacin Approved, Investigational Phase 2 100986-85-4 149096
49 Antiprotozoal Agents Phase 2
50 Anti-Infective Agents, Urinary Phase 2

Interventional clinical trials:

(show all 31)
# Name Status NCT ID Phase Drugs
1 Low Molecular Weight Heparin in Recurrent Miscarriage With Negative Antiphospholipid Antibodies Completed NCT01608347 Phase 4 LMWH+Folic acid;Folic Acid
2 Efficacy of 17 Alpha-hydroxyprogesterones Caproate for the Prevention of Preterm Delivery Completed NCT00331695 Phase 4 17 alpha-hydroxyprogesterones caproate
3 Implantation Failure and PGD Completed NCT00547781 Phase 4
4 The Results of Preimplantation Genetic Diagnosis and Preimplantation Genetic Screening of Embryos Obtained From GnRH-agonist Long and GnRH-antagonist Ovarian Stimulation Protocol Unknown status NCT01636505 Phase 3 ghrh antagonist (cetrotide/orgalutran);gnrh agonist (suprefact)
5 Trial of 4-OHT Gel in Women Aimed at Reducing Dense Breast Tissue Active, not recruiting NCT03199963 Phase 3 4-OH tamoxifen;Placebo
6 Role of Three Dimensional Ultrasound in the Diagnosis of Septate Uterus Completed NCT02597816 Phase 2
7 The Impact of Treating Minor Uterine Cavity Abnormalities Diagnosed by Office Hysteroscopy in Unselected In Vitro Fertilization (IVF) Cases Terminated NCT00830401 Phase 2 Ofloxacinum/Doxycycline
8 Prevalence of Congenital Uterine Malformations Unknown status NCT01487616
9 Prevention of Intrauterine Adhesions After Hysteroscopic Metroplasty With Autocross-linked Hyaluronic Acid Gel Unknown status NCT02404454 Not Applicable
10 Uterine Cavity Assessment and Endometrial Gene Expression in Tamoxifen Treated Breast Cancer Patients Unknown status NCT02311647
11 Description of the Uterine Cavity in Patients With Recurrent Miscarriages Unknown status NCT02746588
12 Value of Routine Hysteroscopy Prior to IVF/ICSI Cycles Unknown status NCT02245750 Not Applicable
13 Maternal Uterine Artery Doppler Study Completed NCT01698957
14 Retrospective Study of 110 Cases of Uterine Rupture to Determine Obstetric and Neonatal Complications Completed NCT03052686
15 Preemptive Analgesia for Abdominal Hysterectomy Completed NCT00121498 Not Applicable Lidocaine (local anesthetics) 20 ml of 1 % subcutaneously
16 Pregnancy Outcomes After Uterine Cavity Expansion Completed NCT03218878
17 Cumulative Live Birth Rates in Patients With Repeated Implantation Failure (RIF) Undergoing Preimplantation Genetic Screening (PGS ) Completed NCT03001648
18 Thrombophilia and Thyroid Autoimmunity in Implantation Failure and Recurrent Miscarriage Completed NCT00485446
19 The Clinical and Biochemical Characteristics in Women With Different Menstrual Pattern Completed NCT01604603
20 Effects of PGS in Infertile Female Patients With RPL Completed NCT02223221 Not Applicable
21 Role of Intrauterine Insemination in Patients With Endometriosis I-II Completed NCT03425604
22 Magnetic Resonance Imaging (MRI) Hysterosalpingography Versus Radiographic Hysterosalpingography in Female Infertility Completed NCT02108665 Not Applicable
23 Clinical Benefits of B-Flow Ultrasound Completed NCT02008097 Not Applicable
24 Effect of Low-frequency Electroacupuncture (EA) on Polycystic Ovary Syndrome Completed NCT01812161 Not Applicable
25 Hysteroscopy in Chronic Anovulation Recruiting NCT03545945 Not Applicable
26 Tissue Samples and Bodily Fluid Specimens Banking Recruiting NCT02431884
27 Hysteroscopic Surgery in Treatment of Intrauterine Abnormalities Recruiting NCT03265301 Not Applicable
28 The Effect of Fasting on ICSI Outcomes in Patients With Polycystic Ovary Syndrome Recruiting NCT03703115 Not Applicable
29 Prevalence, Risk Factors and Consequences Related to Cesarean Scar Defect (Defect in Cesarean Scar) Active, not recruiting NCT02717312
30 Office Hysteroscopy in Secondary Infertility After Cesarean Section Not yet recruiting NCT03166657
31 Endometrial and Myometrial Changes, With and Without Fibroids Withdrawn NCT01671215

Search NIH Clinical Center for Uterine Anomalies

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: uterine diseases

Sources

Genetic Tests for Uterine Anomalies

About this section
Sources

Anatomical Context for Uterine Anomalies

About this section

MalaCards organs/tissues related to Uterine Anomalies:

41
Uterus, Thyroid, Cervix, Ovary, Bone, Tongue, Pancreas

The Foundational Model of Anatomy Ontology organs/tissues related to Uterine Anomalies:

19
The Uterus
Sources

Publications for Uterine Anomalies

About this section

Articles related to Uterine Anomalies:

(show top 50) (show all 137)
# Title Authors Year
1
Outcome of assisted reproduction in women with congenital uterine anomalies: a prospective observational study. ( 29055072 )
2018
2
Re: Outcome of assisted reproduction in women with congenital uterine anomalies: a prospective observational study. M. Prior, A. Richardson, S. Asif, L. Polanski, M. Parris-Larkin, J. Chandler, L. Fogg, P. Jassal, J. G. Thornton, N. J. Raine-Fenning. Ultrasound Obstet Gynecol 2018; 51: 110-117. ( 29297614 )
2018
3
Uterine anomalies - Latin anatomy reigns. ( 30004644 )
2018
4
Frequency and types of uterine anomalies during caesarean section. ( 30372654 )
2018
5
Laparoscopic-assisted vaginal hysterectomy versus vaginal hysterectomy for benign uterine diseases: a prospective, randomized, multicenter, double-blind trial (LAVA). ( 29302807 )
2018
6
Adverse effect analysis of high-intensity focused ultrasound in the treatment of benign uterine diseases. ( 29792359 )
2018
7
Undescended or absent ovary without uterine anomalies: systematic review and a single center's experience. ( 28116887 )
2017
8
Fundus Thickness Assessment by 3D Transvaginal Ultrasound Allows Metrics-Based Diagnosis and TreatmentA of Congenital Uterine Anomalies. ( 26085458 )
2017
9
The association between obstetrical history and preterm birth in women with uterine anomalies. ( 28651449 )
2017
10
Classification of Uterine Anomalies by 3-Dimensional Ultrasonography Using ESHRE/ESGE Criteria: Interobserver Variability. ( 28847221 )
2017
11
Endometrial cancer with congenital uterine anomalies: 3 case reports and a literature review. ( 28118070 )
2017
12
Diagnosis and Management of Congenital Uterine Anomalies in Pregnancy. ( 28304417 )
2017
13
The association of plasma glucose, BHBA, and NEFA with postpartum uterine diseases, fertility, and milk production of Holstein dairy cows. ( 27793454 )
2017
14
Dynamics of the microbiota found in the vaginas of dairy cows during the transition period: Associations with uterine diseases and reproductive outcome. ( 28189315 )
2017
15
Molecular aspects of uterine diseases in dogs. ( 28815849 )
2017
16
Training Performance in Diagnosis of Congenital Uterine Anomalies With 3-Dimensional Sonography: A Learning Curve Cumulative Summation Analysis. ( 27872415 )
2016
17
Undescended or absent ovary without uterine anomalies: systematic review and a single-center experience. ( 27727203 )
2016
18
Congenital Uterine Anomalies and Uterine Rupture. ( 26990544 )
2016
19
Longitudinal vaginal septa with associated uterine anomalies: a case series. ( 25349941 )
2015
20
Pictorial Review of Complications of Uterine Anomalies. ( 26601928 )
2015
21
Does surgery improve live birth rates in patients with recurrent miscarriage caused by uterine anomalies? ( 25058627 )
2015
22
Reliability of the European Society of Human Reproduction and Embryology/European Society for Gynaecological Endoscopy and American Society for Reproductive Medicine classification systems for congenital uterine anomalies detected using three-dimensional ultrasonography. ( 26158905 )
2015
23
Association between HSD17B1 rs605059 polymorphisms and the risk of uterine diseases: a systemic review and meta-analysis. ( 26261478 )
2015
24
Pattern of Congenital Uterine Anomalies Among Infertile Women in Southwest Nigeria. ( 27678894 )
2015
25
A Modified Nerve-Sparing Panhysterectomy for Benign Uterine Diseases: Techniques and Evaluation of Postoperative Pelvic Dysfunctions. ( 25823505 )
2015
26
Contrast-enhanced ultrasound for evaluation of high-intensity focused ultrasound treatment of benign uterine diseases: retrospective analysis of contrast safety. ( 25906100 )
2015
27
Postpartum uterine diseases and their impacts on conception and days open in dairy herds in Italy. ( 26210315 )
2015
28
Characterization of peripartum rumination and activity of cows diagnosed with metabolic and uterine diseases. ( 26233440 )
2015
29
Usefulness of three dimensional transvaginal ultrasonography and hysterosalpingography in diagnosing uterine anomalies. ( 25011216 )
2014
30
Polycystic ovarian syndrome and congenital uterine anomalies: the hidden common player. ( 24615567 )
2014
31
A classification of congenital uterine anomalies predicting pregnancy outcomes. ( 24773088 )
2014
32
Clinical implications of congenital uterine anomalies: a meta-analysis of comparative studies. ( 25444500 )
2014
33
Effect of trace mineral supplementation on selected minerals, energy metabolites, oxidative stress, and immune parameters and its association with uterine diseases in dairy cattle. ( 24835975 )
2014
34
Diagnostic and prognostic markers for uterine diseases in dogs. ( 24947856 )
2014
35
Risk factors for uterine diseases on small- and medium-sized dairy farms determined by clinical, bacteriological, and cytological examinations. ( 25066047 )
2014
36
Use of 3-dimensional sonography to assess uterine anomalies. ( 23269704 )
2013
37
Effect of prior birth and miscarriage frequency on the prevalence of acquired and congenital uterine anomalies in women with recurrent miscarriage: a cross-sectional study. ( 23472945 )
2013
38
Accuracy of 3-dimensional sonography for diagnosis and classification of congenital uterine anomalies. ( 23716512 )
2013
39
Innate immune gene variation and differential susceptibility to uterine diseases in Holstein cows. ( 23768650 )
2013
40
Pregnant uterine anomalies may be difficult to diagnose only by 2-dimensional ultrasound. ( 22727218 )
2012
41
Imaging diagnosis of uterine anomalies. ( 22808635 )
2012
42
Association between virulence factors of Escherichia coli, Fusobacterium necrophorum, and Arcanobacterium pyogenes and uterine diseases of dairy cows. ( 22186615 )
2012
43
Enzymes of the AKR1B and AKR1C Subfamilies and Uterine Diseases. ( 22419909 )
2012
44
Congenital uterine anomalies and adverse pregnancy outcomes. ( 21907963 )
2011
45
Prevalence of uterine anomalies and their impact on early pregnancy in women conceiving after assisted reproduction treatment. ( 21337662 )
2011
46
The prevalence of congenital uterine anomalies in unselected and high-risk populations: a systematic review. ( 21705770 )
2011
47
Reproductive outcomes in women with congenital uterine anomalies: a systematic review. ( 21830244 )
2011
48
Effects of postpartum uterine diseases on milk production and culling in dairy cows. ( 21338799 )
2011
49
Congenital uterine anomalies affecting reproduction. ( 19897423 )
2010
50
The pattern of pregnancy loss in women with congenital uterine anomalies and recurrent miscarriage. ( 20093084 )
2010
Sources

Variations for Uterine Anomalies

About this section
Sources

Expression for Uterine Anomalies

About this section
Search GEO for disease gene expression data for Uterine Anomalies.
Sources

Pathways for Uterine Anomalies

About this section

Pathways related to Uterine Anomalies according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Endometrial cancer 37
Show member pathways
 12.59 AREG CDKN2A MLH1 MSH2 PTEN TP53
2
Pathways in cancer 37
12.52 CDKN2A ESR1 MLH1 MSH2 PTEN TP53
3
Gastric cancer 37
Show member pathways
 12.3 CDKN2A ESR1 MLH1 PGR PTEN TP53
4
Prolactin Signaling Pathway 1 37
Show member pathways
 12.28 CSH1 CSH2 ESR1 PTEN
5
Colorectal Cancer Metastasis 64
12.03 MLH1 MSH2 TLR9 TP53
6
Direct p53 effectors 1
11.83 MLH1 MSH2 PTEN TP53
7
Integrated Cancer Pathway 1
11.33 MSH2 PTEN TP53
8
Doxorubicin Pathway, Pharmacokinetics 61
Show member pathways
 11.23 MLH1 MSH2 TP53
9
Integrated Breast Cancer Pathway 1
11.21 CYP19A1 ESR1 MSH2 PTEN TP53
10
Ovarian tumor domain proteases 66
11.18 ESR1 PTEN TP53
11
Platinum drug resistance 37
11.12 CDKN2A MLH1 MSH2 TP53
12
Ovarian Infertility Genes 1
10.94 CYP19A1 MLH1 PGR
13
Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics 61
10.08 CYP19A1 ESR1
Sources

GO Terms for Uterine Anomalies

About this section

Cellular components related to Uterine Anomalies according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatch repair complex GO:0032300 8.62 MLH1 MSH2

Biological processes related to Uterine Anomalies according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.95 AREG CSH1 CSH2 MAPK8IP2 OXT
2 positive regulation of gene expression GO:0010628 9.93 CDKN2A HNF1B PTEN TLR9 TP53
3 response to glucose GO:0009749 9.73 HNF1B PTEN PTPRN
4 social behavior GO:0035176 9.65 MAPK8IP2 OXT PTEN
5 response to cAMP GO:0051591 9.63 AREG OXT PTPRN
6 determination of adult lifespan GO:0008340 9.62 MSH2 TP53
7 maternal behavior GO:0042711 9.61 OXT PTEN
8 protein localization to chromatin GO:0071168 9.61 ESR1 MSH2
9 replicative senescence GO:0090399 9.6 CDKN2A TP53
10 growth hormone receptor signaling pathway GO:0060396 9.59 CSH1 CSH2
11 positive regulation of growth GO:0045927 9.58 CSH1 CSH2
12 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.58 ESR1 TP53
13 positive regulation of isotype switching to IgG isotypes GO:0048304 9.57 MLH1 MSH2
14 response to organic cyclic compound GO:0014070 9.56 AREG HNF1B OXT PTEN
15 obsolete negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 9.51 CDKN2A PTEN
16 prostate gland growth GO:0060736 9.49 CYP19A1 PTEN
17 response to estradiol GO:0032355 9.46 AREG ESR1 OXT PTEN
18 male mating behavior GO:0060179 9.43 OXT PTEN
19 positive regulation of isotype switching to IgA isotypes GO:0048298 9.4 MLH1 MSH2
20 epithelial cell proliferation involved in mammary gland duct elongation GO:0060750 9.37 AREG ESR1
21 somatic recombination of immunoglobulin gene segments GO:0016447 9.32 MLH1 MSH2
22 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 8.96 MLH1 MSH2
23 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 8.92 AREG CSH1 CSH2 TP53
24 positive regulation of transcription by RNA polymerase II GO:0045944 10.07 CDKN2A ESR1 HNF1B PGR PTPRN TLR9

Molecular functions related to Uterine Anomalies according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.43 ESR1 MLH1 MSH2 PGR PTEN TP53
2 mismatched DNA binding GO:0030983 9.37 MLH1 MSH2
3 growth hormone receptor binding GO:0005131 9.32 CSH1 CSH2
4 MAP-kinase scaffold activity GO:0005078 9.26 MAPK8IP1 MAPK8IP2
5 protein kinase binding GO:0019901 9.17 CDKN2A ESR1 MAPK8IP1 MAPK8IP2 MSH2 PTEN
6 guanine/thymine mispair binding GO:0032137 9.16 MLH1 MSH2
Sources

Sources for Uterine Anomalies

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....