MCID: UTR031
MIFTS: 33

Uterine Benign Neoplasm

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Uterine Benign Neoplasm

MalaCards integrated aliases for Uterine Benign Neoplasm:

Name: Uterine Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060095

Summaries for Uterine Benign Neoplasm

Disease Ontology : 12 A female reproductive organ benign neoplasm that is located in the uterus.

MalaCards based summary : Uterine Benign Neoplasm is related to leiomyoma, uterine and endometrial hyperplasia. An important gene associated with Uterine Benign Neoplasm is HPSE2 (Heparanase 2 (Inactive)), and among its related pathways/superpathways are Glioma and Development EGFR signaling pathway. Affiliated tissues include uterus, ovary and skin, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and Increased TP53 mRNA expression

Related Diseases for Uterine Benign Neoplasm

Diseases related to Uterine Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 leiomyoma, uterine 31.7 ESR1 FH HMGA2 PGR RAD51B
2 endometrial hyperplasia 11.2
3 uterine corpus adenomatoid tumor 11.2
4 endometrial stromal nodule 11.2
5 uterine corpus bizarre leiomyoma 11.2
6 uterine corpus adenofibroma 11.2
7 uterine corpus leiomyomatosis 11.2
8 uterine corpus cellular leiomyoma 11.2
9 vestibular gland benign neoplasm 10.5 ESR1 PGR
10 bartholin's gland adenoma 10.5 ESR1 PGR
11 breast duct papilloma 10.5 PGR PTEN
12 vulvar syringoma 10.5 ESR1 PGR
13 lung leiomyoma 10.5 ESR1 PGR
14 glassy cell carcinoma of the cervix 10.4 ESR1 PGR
15 vulvar benign neoplasm 10.4 ESR1 PGR
16 trigonitis 10.4 ESR1 PGR
17 vulvar leiomyoma 10.4 ESR1 PGR
18 endometrium carcinoma in situ 10.4 PGR TP53
19 pleomorphic lipoma 10.4 HMGA2 PGR
20 breast medullary carcinoma 10.4 ESR1 PGR
21 breast scirrhous carcinoma 10.4 ESR1 PGR
22 bartholin's gland benign neoplasm 10.4 ESR1 PGR
23 bizarre leiomyoma 10.4 MED12 PGR
24 skin lipoma 10.4 HMGA2 PTEN
25 oncocytic breast carcinoma 10.4 ESR1 PGR
26 peritoneal benign neoplasm 10.4 ESR1 MED12 PGR
27 diffuse peritoneal leiomyomatosis 10.4 ESR1 MED12 PGR
28 endometrial squamous cell carcinoma 10.3 ESR1 PGR
29 smooth muscle tumor 10.3 ESR1 HMGA2 PGR
30 cribriform carcinoma 10.3 ESR1 PGR
31 adenomyosis 10.3 ESR1 GNRH1 PGR
32 cervical carcinosarcoma 10.3 ESR1 PGR TP53
33 glycogen-rich clear cell breast carcinoma 10.3 ESR1 PGR TP53
34 juvenile nasopharyngeal angiofibroma 10.3 ESR1 PGR TGFB3
35 adenosarcoma 10.3 ESR1 PGR TP53
36 progesterone-receptor positive breast cancer 10.3 ESR1 ESR2 PGR
37 carcinosarcoma 10.3 PGR PTEN TP53
38 progesterone resistance 10.3 ESR1 ESR2 PGR
39 gender identity disorder 10.3 ESR1 ESR2 PGR
40 pre-malignant neoplasm 10.3 ESR1 PGR TP53
41 fallopian tube carcinoma 10.3 ESR1 PGR TP53
42 estrogen excess 10.3 ESR1 ESR2 PGR
43 breast malignant phyllodes tumor 10.3 PGR TP53
44 in situ carcinoma 10.3 ESR1 PGR TP53
45 endometriosis of ovary 10.3 ESR1 ESR2 PGR
46 postmenopausal atrophic vaginitis 10.3 ESR1 ESR2
47 adenoid basal cell carcinoma 10.3 ESR1 PGR
48 breast carcinoma in situ 10.3 ESR1 PGR TP53
49 malignant ovarian surface epithelial-stromal neoplasm 10.3 ESR1 PGR TP53
50 ovary epithelial cancer 10.3 ESR1 PGR TP53

Graphical network of the top 20 diseases related to Uterine Benign Neoplasm:



Diseases related to Uterine Benign Neoplasm

Symptoms & Phenotypes for Uterine Benign Neoplasm

GenomeRNAi Phenotypes related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.35 ESR1 ESR2 FH PTEN RAD51B
2 Increased TP53 mRNA expression GR00389-S-6 8.8 ESR2 HMGA2 TP53

MGI Mouse Phenotypes related to Uterine Benign Neoplasm:

47 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.29 CD3E ESR1 ESR2 FH MED12 PAX2
2 mortality/aging MP:0010768 10.25 CD3E ESR1 ESR2 FH HPSE2 MED12
3 homeostasis/metabolism MP:0005376 10.22 CCDC57 ESR1 ESR2 FH GNRH1 HPSE2
4 cardiovascular system MP:0005385 10.21 ESR1 ESR2 MED12 PAX2 PGR PTEN
5 endocrine/exocrine gland MP:0005379 10.21 CD3E ESR1 ESR2 GNRH1 PAX2 PGR
6 hematopoietic system MP:0005397 10.19 CCDC57 CD3E ESR1 ESR2 GNRH1 PGR
7 digestive/alimentary MP:0005381 10.14 ESR1 ESR2 GNRH1 HPSE2 PTEN RB1
8 embryo MP:0005380 10.13 ESR1 MED12 PAX2 PGR PTEN RB1
9 integument MP:0010771 10.06 CD3E ESR1 ESR2 GNRH1 PGR PTEN
10 limbs/digits/tail MP:0005371 10.03 ESR1 ESR2 MED12 PGR PTEN RB1
11 nervous system MP:0003631 10.02 CD3E ESR1 ESR2 GNRH1 MED12 PAX2
12 neoplasm MP:0002006 9.97 CD3E ESR1 ESR2 GNRH1 PGR PTEN
13 normal MP:0002873 9.91 ESR1 ESR2 GNRH1 MED12 PGR PTEN
14 renal/urinary system MP:0005367 9.81 ESR1 ESR2 FH GNRH1 HPSE2 PAX2
15 reproductive system MP:0005389 9.61 ESR1 ESR2 GNRH1 PAX2 PGR PTEN
16 skeleton MP:0005390 9.32 CCDC57 ESR1 ESR2 GNRH1 MED12 PGR

Drugs & Therapeutics for Uterine Benign Neoplasm

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 High-intensity Focused Ultrasound in Treatment of Uterine Fibroid Completed NCT02954744 Not Applicable

Search NIH Clinical Center for Uterine Benign Neoplasm

Genetic Tests for Uterine Benign Neoplasm

Anatomical Context for Uterine Benign Neoplasm

MalaCards organs/tissues related to Uterine Benign Neoplasm:

42
Uterus, Ovary, Skin, Cervix, Smooth Muscle

The Foundational Model of Anatomy Ontology organs/tissues related to Uterine Benign Neoplasm:

20
The Uterus

Publications for Uterine Benign Neoplasm

Variations for Uterine Benign Neoplasm

Expression for Uterine Benign Neoplasm

Search GEO for disease gene expression data for Uterine Benign Neoplasm.

Pathways for Uterine Benign Neoplasm

Pathways related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.45 ESR1 ESR2 PTEN RB1 TP53
2
Show member pathways
12.36 CD3E RB1 TGFB3 TP53
3 12.22 ESR1 ESR2 FH PTEN RB1 TGFB3
4 12.12 CD3E RB1 TGFB3 TP53
5 11.91 PTEN RB1 TGFB3 TP53
6 11.86 ESR1 PTEN RB1 TP53
7
Show member pathways
11.83 ESR1 ESR2 PGR PTEN RB1 TGFB3
8 11.81 ESR1 MED12 TP53
9 11.78 PTEN RB1 TP53
10 11.74 PTEN RB1 TP53
11 11.68 ESR1 ESR2 TGFB3
12 11.65 PTEN RB1 TP53
13
Show member pathways
11.63 ESR1 ESR2 PGR
14 11.27 PTEN RB1 TP53
15 11 ESR1 PTEN TP53
16 10.75 PAX2 RB1
17 10.69 ESR1 ESR2 RB1
18 9.92 ESR1 ESR2

GO Terms for Uterine Benign Neoplasm

Cellular components related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 PML body GO:0016605 8.8 PTEN RB1 TP53

Biological processes related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.91 GNRH1 HMGA2 PAX2 PTEN TP53
2 regulation of apoptotic process GO:0042981 9.8 CD3E ESR1 TGFB3 TP53
3 negative regulation of cell proliferation GO:0008285 9.8 GNRH1 PTEN RB1 TGFB3 TP53
4 negative regulation of gene expression GO:0010629 9.78 CD3E ESR1 PGR RB1
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.72 ESR1 ESR2 PTEN
6 aging GO:0007568 9.62 GNRH1 PAX2 PTEN TGFB3
7 transcription initiation from RNA polymerase II promoter GO:0006367 9.56 ESR1 ESR2 MED12 PGR
8 positive regulation of transcription by RNA polymerase II GO:0045944 9.56 ESR1 HMGA2 MED12 PAX2 PGR RB1
9 positive regulation of transcription regulatory region DNA binding GO:2000679 9.52 HMGA2 RB1
10 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.46 ESR1 TP53
11 transcription, DNA-templated GO:0006351 9.43 ESR1 PAX2
12 embryonic neurocranium morphogenesis GO:0048702 9.37 MED12 TGFB3
13 stem cell differentiation GO:0048863 9.33 ESR1 HMGA2 PAX2
14 intracellular steroid hormone receptor signaling pathway GO:0030518 9.24 ESR1
15 positive regulation of transcription, DNA-templated GO:0045893 9.23 ESR1 ESR2 HMGA2 MED12 PAX2 RB1
16 regulation of transcription, DNA-templated GO:0006355 10.1 ESR1 ESR2 HMGA2 PAX2 PGR RB1

Molecular functions related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.95 ESR1 ESR2 PGR PTEN RB1 TGFB3
2 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.85 ESR1 ESR2 HMGA2 PGR TP53
3 lipid binding GO:0008289 9.8 ESR1 ESR2 PGR PTEN
4 steroid hormone receptor activity GO:0003707 9.61 ESR1 ESR2 PGR
5 nuclear receptor activity GO:0004879 9.5 ESR1 ESR2 PGR
6 enzyme binding GO:0019899 9.43 ESR1 ESR2 PGR PTEN RB1 TP53
7 estrogen receptor activity GO:0030284 9.37 ESR1 ESR2
8 steroid binding GO:0005496 9.33 ESR1 ESR2 PGR
9 estrogen response element binding GO:0034056 9.26 ESR1 ESR2
10 transcription factor binding GO:0008134 9.1 ESR1 HMGA2 MED12 PAX2 RB1 TP53
11 protein binding GO:0005515 10.38 CCDC57 CD3E ESR1 ESR2 FH HMGA2

Sources for Uterine Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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