Uterine Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Uterine Benign Neoplasm

MalaCards integrated aliases for Uterine Benign Neoplasm:

Name: Uterine Benign Neoplasm ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060095

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Summaries for Uterine Benign Neoplasm

Disease Ontology : ¹² A female reproductive organ benign neoplasm that is located in the uterus.

MalaCards based summary : Uterine Benign Neoplasm is related to leiomyoma, uterine and endometrial hyperplasia. An important gene associated with Uterine Benign Neoplasm is HPSE2 (Heparanase 2 (Inactive)), and among its related pathways/superpathways are Pathways in cancer and Gastric cancer. Affiliated tissues include uterus and uterus, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and growth/size/body region

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Related Diseases for Uterine Benign Neoplasm

Diseases related to Uterine Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)

#	Related Disease	Score	Top Affiliating Genes
1	leiomyoma, uterine	32.3	RAD51B PGR HMGA2 FH ESR1
2	endometrial hyperplasia	11.3
3	uterine corpus adenomatoid tumor	11.3
4	endometrial stromal nodule	11.3
5	uterine corpus bizarre leiomyoma	11.3
6	uterine corpus adenofibroma	11.3
7	uterine corpus leiomyomatosis	11.3
8	uterine corpus cellular leiomyoma	11.3
9	bartholin's gland adenoma	10.8	PGR ESR1
10	vestibular gland benign neoplasm	10.8	PGR ESR1
11	lung leiomyoma	10.8	PGR ESR1
12	vulvar syringoma	10.8	PGR ESR1
13	breast duct papilloma	10.7	PTEN PGR
14	glassy cell carcinoma of the cervix	10.7	PGR ESR1
15	vulvar leiomyoma	10.7	PGR ESR1
16	pleomorphic lipoma	10.7	PGR HMGA2
17	trigonitis	10.7	PGR ESR1
18	vulvar benign neoplasm	10.7	PGR ESR1
19	predominantly cortical thymoma	10.7	PGR ESR1
20	bizarre leiomyoma	10.7	PGR MED12
21	breast scirrhous carcinoma	10.7	PGR ESR1
22	breast medullary carcinoma	10.7	PGR ESR1
23	skin lipoma	10.7	PTEN HMGA2
24	oncocytic breast carcinoma	10.7	PGR ESR1
25	endometrium carcinoma in situ	10.7	TP53 PGR
26	bartholin's gland benign neoplasm	10.6	PGR ESR1
27	diffuse peritoneal leiomyomatosis	10.6	PGR MED12 ESR1
28	peritoneal benign neoplasm	10.6	PGR MED12 ESR1
29	smooth muscle tumor	10.6	PGR HMGA2 ESR1
30	progesterone-receptor positive breast cancer	10.6	PGR ESR1
31	cribriform carcinoma	10.6	PGR ESR1
32	endometrial squamous cell carcinoma	10.5	PGR ESR1
33	juvenile nasopharyngeal angiofibroma	10.5	TGFB3 PGR ESR1
34	progesterone resistance	10.5	PGR ESR1
35	breast malignant phyllodes tumor	10.5	TP53 PGR
36	apocrine adenocarcinoma	10.5	PGR ESR1
37	freemartinism	10.5	GNRH1 AMH
38	pleomorphic adenoma carcinoma	10.5	TP53 HMGA2
39	cervical carcinosarcoma	10.5	TP53 PGR ESR1
40	glycogen-rich clear cell breast carcinoma	10.5	TP53 PGR ESR1
41	adenosarcoma	10.5	TP53 PGR ESR1
42	uterine corpus cancer	10.5	TP53 PGR ESR1
43	pre-malignant neoplasm	10.5	TP53 PGR ESR1
44	olfactory groove meningioma	10.5	TP53 PGR
45	fallopian tube carcinoma	10.5	TP53 PGR ESR1
46	adenoid basal cell carcinoma	10.5	PGR ESR1
47	carcinosarcoma	10.5	TP53 PTEN PGR
48	in situ carcinoma	10.5	TP53 PGR ESR1
49	breast carcinoma in situ	10.4	TP53 PGR ESR1
50	male reproductive system disease	10.4	TP53 PTEN GNRH1

Graphical network of the top 20 diseases related to Uterine Benign Neoplasm:

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Symptoms & Phenotypes for Uterine Benign Neoplasm

GenomeRNAi Phenotypes related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)	GR00104-A-0	8.92	ESR1 FH PTEN RAD51B

MGI Mouse Phenotypes related to Uterine Benign Neoplasm:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	10.11	ESR1 GNRH1 HOXA10 HPSE2 MED12 MFN2
2	mortality/aging	MP:0010768	10.07	CD3E ESR1 FH HPSE2 MED12 MFN2
3	digestive/alimentary	MP:0005381	9.95	ESR1 GNRH1 HOXA10 HPSE2 PTEN TGFB3
4	limbs/digits/tail	MP:0005371	9.87	ESR1 HOXA10 MED12 PGR PTEN TGFB3
5	neoplasm	MP:0002006	9.7	AMH CD3E ESR1 GNRH1 PGR PTEN
6	normal	MP:0002873	9.56	ESR1 GNRH1 MED12 MFN2 PGR PTEN
7	skeleton	MP:0005390	9.28	ESR1 GNRH1 HOXA10 MED12 MFN2 PGR

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Drugs & Therapeutics for Uterine Benign Neoplasm

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Therapeutic Efficacy of High-intensity Focused Ultrasound in the Treatment of Uterine Fibroid	Completed	NCT02954744

Search NIH Clinical Center for Uterine Benign Neoplasm

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Genetic Tests for Uterine Benign Neoplasm

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Anatomical Context for Uterine Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Uterine Benign Neoplasm:

¹⁹

Uterus

MalaCards organs/tissues related to Uterine Benign Neoplasm:

⁴¹

Uterus

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Publications for Uterine Benign Neoplasm

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Genes for Uterine Benign Neoplasm

Genes related to Uterine Benign Neoplasm (0 elite genes):

(show all 21)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	HPSE2	Heparanase 2 (Inactive)	Protein Coding	18.69	DISEASES inferred ¹⁵
2	PGR	Progesterone Receptor	Protein Coding	18.03	DISEASES inferred ¹⁵
3	MED12	Mediator Complex Subunit 12	Protein Coding	17.96	DISEASES inferred ¹⁵
4	FH	Fumarate Hydratase	Protein Coding	17.66	DISEASES inferred ¹⁵
5	HMGA2	High Mobility Group AT-Hook 2	Protein Coding	17.24	DISEASES inferred ¹⁵
6	ESR1	Estrogen Receptor 1	Protein Coding	16.9	DISEASES inferred ¹⁵
7	GNRH1	Gonadotropin Releasing Hormone 1	Protein Coding	16.81	DISEASES inferred ¹⁵
8	PTEN	Phosphatase And Tensin Homolog	Protein Coding	16.28	DISEASES inferred ¹⁵
9	RAD51B	RAD51 Paralog B	Protein Coding	16.14	DISEASES inferred ¹⁵
10	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	15.83	DISEASES inferred ¹⁵
11	TNRC6B	Trinucleotide Repeat Containing Adaptor 6B	Protein Coding	15.75	DISEASES inferred ¹⁵
12	AMH	Anti-Mullerian Hormone	Protein Coding	15.73	DISEASES inferred ¹⁵
13	CD3E	CD3e Molecule	Protein Coding	15.66	DISEASES inferred ¹⁵
14	TP53	Tumor Protein P53	Protein Coding	15.56	DISEASES inferred ¹⁵
15	HOXA10	Homeobox A10	Protein Coding	15.56	DISEASES inferred ¹⁵
16	JAZF1	JAZF Zinc Finger 1	Protein Coding	15.56	DISEASES inferred ¹⁵
17	PRDM10	PR/SET Domain 10	Protein Coding	15.54	DISEASES inferred ¹⁵
18	MFN2	Mitofusin 2	Protein Coding	15.5	DISEASES inferred ¹⁵
19	TMSB15A	Thymosin Beta 15a	Protein Coding	6.86	DISEASES inferred ¹⁵ ¹⁵
20	BET1L	Bet1 Golgi Vesicular Membrane Trafficking Protein Like	Protein Coding	5.67	DISEASES inferred ¹⁵
21	IGF1	Insulin Like Growth Factor 1	Protein Coding	5.49	DISEASES inferred ¹⁵

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Variations for Uterine Benign Neoplasm

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Expression for Uterine Benign Neoplasm

Search GEO for disease gene expression data for Uterine Benign Neoplasm.

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Pathways for Uterine Benign Neoplasm

Pathways related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Pathways in cancer ³⁷	12.38	TP53 TGFB3 PTEN FH ESR1
2	Gastric cancer ³⁷ Show member pathways Breast cancer ³⁷ Hepatocellular carcinoma ³⁷	12.02	TP53 TGFB3 PTEN PGR ESR1
3	Thyroid hormone signaling pathway ³⁷	11.57	TP53 MED12 ESR1
4	TP53 Regulates Metabolic Genes ⁶⁶	11.26	TP53 TNRC6B PTEN
5	Ovarian tumor domain proteases ⁶⁶	10.37	TP53 PTEN ESR1

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GO Terms for Uterine Benign Neoplasm

Biological processes related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription, DNA-templated	GO:0045893	9.88	TP53 TGFB3 MED12 HMGA2 ESR1
2	positive regulation of transcription by RNA polymerase II	GO:0045944	9.8	TP53 TGFB3 PGR MED12 HOXA10 HMGA2
3	regulation of apoptotic process	GO:0042981	9.71	TP53 TGFB3 ESR1 CD3E
4	negative regulation of gene expression	GO:0010629	9.67	TNRC6B PGR ESR1 CD3E
5	uterus development	GO:0060065	9.46	HOXA10 ESR1
6	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	GO:0045899	9.32	TP53 ESR1
7	aging	GO:0007568	9.26	TGFB3 PTEN GNRH1 AMH
8	embryonic neurocranium morphogenesis	GO:0048702	9.16	TGFB3 MED12
9	intracellular steroid hormone receptor signaling pathway	GO:0030518	9.13	ESR1
10	positive regulation of gene expression	GO:0010628	9.1	TP53 TNRC6B PTEN HMGA2 CD3E AMH

Molecular functions related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	RNA polymerase II proximal promoter sequence-specific DNA binding	GO:0000978	9.02	TP53 PGR HOXA10 HMGA2 ESR1

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