Uterine Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Uterine Benign Neoplasm

MalaCards integrated aliases for Uterine Benign Neoplasm:

Name: Uterine Benign Neoplasm ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060095

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Summaries for Uterine Benign Neoplasm

Disease Ontology : ¹² A female reproductive organ benign neoplasm that is located in the uterus.

MalaCards based summary : Uterine Benign Neoplasm is related to leiomyoma, uterine and endometrial hyperplasia. An important gene associated with Uterine Benign Neoplasm is HPSE2 (Heparanase 2 (Inactive)), and among its related pathways/superpathways are Glioma and Development EGFR signaling pathway. Affiliated tissues include uterus, ovary and skin, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and Increased TP53 mRNA expression

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Related Diseases for Uterine Benign Neoplasm

Diseases related to Uterine Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)

#	Related Disease	Score	Top Affiliating Genes
1	leiomyoma, uterine	31.7	ESR1 FH HMGA2 PGR RAD51B
2	endometrial hyperplasia	11.2
3	uterine corpus adenomatoid tumor	11.2
4	endometrial stromal nodule	11.2
5	uterine corpus bizarre leiomyoma	11.2
6	uterine corpus adenofibroma	11.2
7	uterine corpus leiomyomatosis	11.2
8	uterine corpus cellular leiomyoma	11.2
9	vestibular gland benign neoplasm	10.5	ESR1 PGR
10	bartholin's gland adenoma	10.5	ESR1 PGR
11	breast duct papilloma	10.5	PGR PTEN
12	vulvar syringoma	10.5	ESR1 PGR
13	lung leiomyoma	10.5	ESR1 PGR
14	glassy cell carcinoma of the cervix	10.4	ESR1 PGR
15	vulvar benign neoplasm	10.4	ESR1 PGR
16	trigonitis	10.4	ESR1 PGR
17	vulvar leiomyoma	10.4	ESR1 PGR
18	endometrium carcinoma in situ	10.4	PGR TP53
19	pleomorphic lipoma	10.4	HMGA2 PGR
20	breast medullary carcinoma	10.4	ESR1 PGR
21	breast scirrhous carcinoma	10.4	ESR1 PGR
22	bartholin's gland benign neoplasm	10.4	ESR1 PGR
23	bizarre leiomyoma	10.4	MED12 PGR
24	skin lipoma	10.4	HMGA2 PTEN
25	oncocytic breast carcinoma	10.4	ESR1 PGR
26	peritoneal benign neoplasm	10.4	ESR1 MED12 PGR
27	diffuse peritoneal leiomyomatosis	10.4	ESR1 MED12 PGR
28	endometrial squamous cell carcinoma	10.3	ESR1 PGR
29	smooth muscle tumor	10.3	ESR1 HMGA2 PGR
30	cribriform carcinoma	10.3	ESR1 PGR
31	adenomyosis	10.3	ESR1 GNRH1 PGR
32	cervical carcinosarcoma	10.3	ESR1 PGR TP53
33	glycogen-rich clear cell breast carcinoma	10.3	ESR1 PGR TP53
34	juvenile nasopharyngeal angiofibroma	10.3	ESR1 PGR TGFB3
35	adenosarcoma	10.3	ESR1 PGR TP53
36	progesterone-receptor positive breast cancer	10.3	ESR1 ESR2 PGR
37	carcinosarcoma	10.3	PGR PTEN TP53
38	progesterone resistance	10.3	ESR1 ESR2 PGR
39	gender identity disorder	10.3	ESR1 ESR2 PGR
40	pre-malignant neoplasm	10.3	ESR1 PGR TP53
41	fallopian tube carcinoma	10.3	ESR1 PGR TP53
42	estrogen excess	10.3	ESR1 ESR2 PGR
43	breast malignant phyllodes tumor	10.3	PGR TP53
44	in situ carcinoma	10.3	ESR1 PGR TP53
45	endometriosis of ovary	10.3	ESR1 ESR2 PGR
46	postmenopausal atrophic vaginitis	10.3	ESR1 ESR2
47	adenoid basal cell carcinoma	10.3	ESR1 PGR
48	breast carcinoma in situ	10.3	ESR1 PGR TP53
49	malignant ovarian surface epithelial-stromal neoplasm	10.3	ESR1 PGR TP53
50	ovary epithelial cancer	10.3	ESR1 PGR TP53

Graphical network of the top 20 diseases related to Uterine Benign Neoplasm:

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Symptoms & Phenotypes for Uterine Benign Neoplasm

GenomeRNAi Phenotypes related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)	GR00104-A-0	9.35	ESR1 ESR2 FH PTEN RAD51B
2	Increased TP53 mRNA expression	GR00389-S-6	8.8	ESR2 HMGA2 TP53

MGI Mouse Phenotypes related to Uterine Benign Neoplasm:

⁴⁷ (show all 16)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10.29	CD3E ESR1 ESR2 FH MED12 PAX2
2	mortality/aging	MP:0010768	10.25	CD3E ESR1 ESR2 FH HPSE2 MED12
3	homeostasis/metabolism	MP:0005376	10.22	CCDC57 ESR1 ESR2 FH GNRH1 HPSE2
4	cardiovascular system	MP:0005385	10.21	ESR1 ESR2 MED12 PAX2 PGR PTEN
5	endocrine/exocrine gland	MP:0005379	10.21	CD3E ESR1 ESR2 GNRH1 PAX2 PGR
6	hematopoietic system	MP:0005397	10.19	CCDC57 CD3E ESR1 ESR2 GNRH1 PGR
7	digestive/alimentary	MP:0005381	10.14	ESR1 ESR2 GNRH1 HPSE2 PTEN RB1
8	embryo	MP:0005380	10.13	ESR1 MED12 PAX2 PGR PTEN RB1
9	integument	MP:0010771	10.06	CD3E ESR1 ESR2 GNRH1 PGR PTEN
10	limbs/digits/tail	MP:0005371	10.03	ESR1 ESR2 MED12 PGR PTEN RB1
11	nervous system	MP:0003631	10.02	CD3E ESR1 ESR2 GNRH1 MED12 PAX2
12	neoplasm	MP:0002006	9.97	CD3E ESR1 ESR2 GNRH1 PGR PTEN
13	normal	MP:0002873	9.91	ESR1 ESR2 GNRH1 MED12 PGR PTEN
14	renal/urinary system	MP:0005367	9.81	ESR1 ESR2 FH GNRH1 HPSE2 PAX2
15	reproductive system	MP:0005389	9.61	ESR1 ESR2 GNRH1 PAX2 PGR PTEN
16	skeleton	MP:0005390	9.32	CCDC57 ESR1 ESR2 GNRH1 MED12 PGR

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Drugs & Therapeutics for Uterine Benign Neoplasm

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	High-intensity Focused Ultrasound in Treatment of Uterine Fibroid	Completed	NCT02954744	Not Applicable

Search NIH Clinical Center for Uterine Benign Neoplasm

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Genetic Tests for Uterine Benign Neoplasm

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Anatomical Context for Uterine Benign Neoplasm

MalaCards organs/tissues related to Uterine Benign Neoplasm:

⁴²

Uterus, Ovary, Skin, Cervix, Smooth Muscle

The Foundational Model of Anatomy Ontology organs/tissues related to Uterine Benign Neoplasm:

²⁰

The Uterus

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Publications for Uterine Benign Neoplasm

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Genes for Uterine Benign Neoplasm

Genes related to Uterine Benign Neoplasm (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	HPSE2	Heparanase 2 (Inactive)	Protein Coding	18.25	DISEASES inferred ¹⁵
2	PGR	Progesterone Receptor	Protein Coding	17.68	DISEASES inferred ¹⁵
3	MED12	Mediator Complex Subunit 12	Protein Coding	16.95	DISEASES inferred ¹⁵
4	ESR1	Estrogen Receptor 1	Protein Coding	16.87	DISEASES inferred ¹⁵
5	PTEN	Phosphatase And Tensin Homolog	Protein Coding	16.31	DISEASES inferred ¹⁵
6	GNRH1	Gonadotropin Releasing Hormone 1	Protein Coding	16.17	DISEASES inferred ¹⁵
7	HMGA2	High Mobility Group AT-Hook 2	Protein Coding	16.08	DISEASES inferred ¹⁵
8	CD3E	CD3e Molecule	Protein Coding	15.64	DISEASES inferred ¹⁵
9	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	15.51	DISEASES inferred ¹⁵
10	TP53	Tumor Protein P53	Protein Coding	15.39	DISEASES inferred ¹⁵
11	ESR2	Estrogen Receptor 2	Protein Coding	15.39	DISEASES inferred ¹⁵
12	FH	Fumarate Hydratase	Protein Coding	15.38	DISEASES inferred ¹⁵
13	CCDC57	Coiled-Coil Domain Containing 57	Protein Coding	15.38	DISEASES inferred ¹⁵
14	RAD51B	RAD51 Paralog B	Protein Coding	15.34	DISEASES inferred ¹⁵
15	RB1	RB Transcriptional Corepressor 1	Protein Coding	15.32	DISEASES inferred ¹⁵
16	PAX2	Paired Box 2	Protein Coding	15.31	DISEASES inferred ¹⁵
17	TMSB15A	Thymosin Beta 15a	Protein Coding	7.35	DISEASES inferred ¹⁵ ¹⁵
18	IVL	Involucrin	Protein Coding	6.52	DISEASES inferred ¹⁵
19	S100A6	S100 Calcium Binding Protein A6	Protein Coding	5.57	DISEASES inferred ¹⁵

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Variations for Uterine Benign Neoplasm

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Expression for Uterine Benign Neoplasm

Search GEO for disease gene expression data for Uterine Benign Neoplasm.

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Pathways for Uterine Benign Neoplasm

Pathways related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 18)

#	Super pathways	Score	Top Affiliating Genes
1	Glioma ³⁸ Show member pathways Endocrine resistance ³⁸ Melanoma ³⁸ Non-small cell lung cancer ³⁸ Signaling Pathways in Glioblastoma ¹	12.45	ESR1 ESR2 PTEN RB1 TP53
2	Development EGFR signaling pathway ²³ Show member pathways Development ERBB-family signaling ²³ EGF Pathway ⁶⁵ EGFR Signaling Pathway ⁶⁸ ErbB receptor signaling network ¹	12.36	CD3E RB1 TGFB3 TP53
3	Pathways in cancer ³⁸	12.22	ESR1 ESR2 FH PTEN RB1 TGFB3
4	Human T-cell leukemia virus 1 infection ³⁸	12.12	CD3E RB1 TGFB3 TP53
5	Cellular senescence (KEGG) ³⁸	11.91	PTEN RB1 TGFB3 TP53
6	Integrated Breast Cancer Pathway ¹	11.86	ESR1 PTEN RB1 TP53
7	Gastric cancer ³⁸ Show member pathways Breast cancer ³⁸ Hepatocellular carcinoma ³⁸	11.83	ESR1 ESR2 PGR PTEN RB1 TGFB3
8	Thyroid hormone signaling pathway ³⁸	11.81	ESR1 MED12 TP53
9	Glioblastoma Multiforme ⁶⁵	11.78	PTEN RB1 TP53
10	Senescence and Autophagy in Cancer ¹	11.74	PTEN RB1 TP53
11	TGF-beta Signaling Pathways ⁶⁶	11.68	ESR1 ESR2 TGFB3
12	Small cell lung cancer ³⁸	11.65	PTEN RB1 TP53
13	Nuclear Receptor transcription pathway ⁶⁷ Show member pathways Nuclear Receptors ¹	11.63	ESR1 ESR2 PGR
14	Integrated Cancer Pathway ¹	11.27	PTEN RB1 TP53
15	Ovarian tumor domain proteases ⁶⁷	11	ESR1 PTEN TP53
16	ID signaling pathway ¹	10.75	PAX2 RB1
17	MNAR-PELP1 and Estrogen Receptor Interaction ⁶⁵	10.69	ESR1 ESR2 RB1
18	Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics ⁶²	9.92	ESR1 ESR2

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GO Terms for Uterine Benign Neoplasm

Cellular components related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	PML body	GO:0016605	8.8	PTEN RB1 TP53

Biological processes related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 16)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of apoptotic process	GO:0043066	9.91	GNRH1 HMGA2 PAX2 PTEN TP53
2	regulation of apoptotic process	GO:0042981	9.8	CD3E ESR1 TGFB3 TP53
3	negative regulation of cell proliferation	GO:0008285	9.8	GNRH1 PTEN RB1 TGFB3 TP53
4	negative regulation of gene expression	GO:0010629	9.78	CD3E ESR1 PGR RB1
5	positive regulation of DNA-binding transcription factor activity	GO:0051091	9.72	ESR1 ESR2 PTEN
6	aging	GO:0007568	9.62	GNRH1 PAX2 PTEN TGFB3
7	transcription initiation from RNA polymerase II promoter	GO:0006367	9.56	ESR1 ESR2 MED12 PGR
8	positive regulation of transcription by RNA polymerase II	GO:0045944	9.56	ESR1 HMGA2 MED12 PAX2 PGR RB1
9	positive regulation of transcription regulatory region DNA binding	GO:2000679	9.52	HMGA2 RB1
10	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	GO:0045899	9.46	ESR1 TP53
11	transcription, DNA-templated	GO:0006351	9.43	ESR1 PAX2
12	embryonic neurocranium morphogenesis	GO:0048702	9.37	MED12 TGFB3
13	stem cell differentiation	GO:0048863	9.33	ESR1 HMGA2 PAX2
14	intracellular steroid hormone receptor signaling pathway	GO:0030518	9.24	ESR1
15	positive regulation of transcription, DNA-templated	GO:0045893	9.23	ESR1 ESR2 HMGA2 MED12 PAX2 RB1
16	regulation of transcription, DNA-templated	GO:0006355	10.1	ESR1 ESR2 HMGA2 PAX2 PGR RB1

Molecular functions related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.95	ESR1 ESR2 PGR PTEN RB1 TGFB3
2	RNA polymerase II proximal promoter sequence-specific DNA binding	GO:0000978	9.85	ESR1 ESR2 HMGA2 PGR TP53
3	lipid binding	GO:0008289	9.8	ESR1 ESR2 PGR PTEN
4	steroid hormone receptor activity	GO:0003707	9.61	ESR1 ESR2 PGR
5	nuclear receptor activity	GO:0004879	9.5	ESR1 ESR2 PGR
6	enzyme binding	GO:0019899	9.43	ESR1 ESR2 PGR PTEN RB1 TP53
7	estrogen receptor activity	GO:0030284	9.37	ESR1 ESR2
8	steroid binding	GO:0005496	9.33	ESR1 ESR2 PGR
9	estrogen response element binding	GO:0034056	9.26	ESR1 ESR2
10	transcription factor binding	GO:0008134	9.1	ESR1 HMGA2 MED12 PAX2 RB1 TP53
11	protein binding	GO:0005515	10.38	CCDC57 CD3E ESR1 ESR2 FH HMGA2

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