MCID: UTR031
MIFTS: 25

Uterine Benign Neoplasm

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Uterine Benign Neoplasm

MalaCards integrated aliases for Uterine Benign Neoplasm:

Name: Uterine Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060095

Summaries for Uterine Benign Neoplasm

Disease Ontology : 12 A female reproductive organ benign neoplasm that is located in the uterus.

MalaCards based summary : Uterine Benign Neoplasm is related to leiomyoma, uterine and endometrial hyperplasia. An important gene associated with Uterine Benign Neoplasm is HPSE2 (Heparanase 2 (Inactive)), and among its related pathways/superpathways are Pathways in cancer and Gastric cancer. Affiliated tissues include uterus and uterus, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and growth/size/body region

Related Diseases for Uterine Benign Neoplasm

Diseases related to Uterine Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 leiomyoma, uterine 32.3 RAD51B PGR HMGA2 FH ESR1
2 endometrial hyperplasia 11.3
3 uterine corpus adenomatoid tumor 11.3
4 endometrial stromal nodule 11.3
5 uterine corpus bizarre leiomyoma 11.3
6 uterine corpus adenofibroma 11.3
7 uterine corpus leiomyomatosis 11.3
8 uterine corpus cellular leiomyoma 11.3
9 bartholin's gland adenoma 10.8 PGR ESR1
10 vestibular gland benign neoplasm 10.8 PGR ESR1
11 lung leiomyoma 10.8 PGR ESR1
12 vulvar syringoma 10.8 PGR ESR1
13 breast duct papilloma 10.7 PTEN PGR
14 glassy cell carcinoma of the cervix 10.7 PGR ESR1
15 vulvar leiomyoma 10.7 PGR ESR1
16 pleomorphic lipoma 10.7 PGR HMGA2
17 trigonitis 10.7 PGR ESR1
18 vulvar benign neoplasm 10.7 PGR ESR1
19 predominantly cortical thymoma 10.7 PGR ESR1
20 bizarre leiomyoma 10.7 PGR MED12
21 breast scirrhous carcinoma 10.7 PGR ESR1
22 breast medullary carcinoma 10.7 PGR ESR1
23 skin lipoma 10.7 PTEN HMGA2
24 oncocytic breast carcinoma 10.7 PGR ESR1
25 endometrium carcinoma in situ 10.7 TP53 PGR
26 bartholin's gland benign neoplasm 10.6 PGR ESR1
27 diffuse peritoneal leiomyomatosis 10.6 PGR MED12 ESR1
28 peritoneal benign neoplasm 10.6 PGR MED12 ESR1
29 smooth muscle tumor 10.6 PGR HMGA2 ESR1
30 progesterone-receptor positive breast cancer 10.6 PGR ESR1
31 cribriform carcinoma 10.6 PGR ESR1
32 endometrial squamous cell carcinoma 10.5 PGR ESR1
33 juvenile nasopharyngeal angiofibroma 10.5 TGFB3 PGR ESR1
34 progesterone resistance 10.5 PGR ESR1
35 breast malignant phyllodes tumor 10.5 TP53 PGR
36 apocrine adenocarcinoma 10.5 PGR ESR1
37 freemartinism 10.5 GNRH1 AMH
38 pleomorphic adenoma carcinoma 10.5 TP53 HMGA2
39 cervical carcinosarcoma 10.5 TP53 PGR ESR1
40 glycogen-rich clear cell breast carcinoma 10.5 TP53 PGR ESR1
41 adenosarcoma 10.5 TP53 PGR ESR1
42 uterine corpus cancer 10.5 TP53 PGR ESR1
43 pre-malignant neoplasm 10.5 TP53 PGR ESR1
44 olfactory groove meningioma 10.5 TP53 PGR
45 fallopian tube carcinoma 10.5 TP53 PGR ESR1
46 adenoid basal cell carcinoma 10.5 PGR ESR1
47 carcinosarcoma 10.5 TP53 PTEN PGR
48 in situ carcinoma 10.5 TP53 PGR ESR1
49 breast carcinoma in situ 10.4 TP53 PGR ESR1
50 male reproductive system disease 10.4 TP53 PTEN GNRH1

Graphical network of the top 20 diseases related to Uterine Benign Neoplasm:



Diseases related to Uterine Benign Neoplasm

Symptoms & Phenotypes for Uterine Benign Neoplasm

GenomeRNAi Phenotypes related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 8.92 ESR1 FH PTEN RAD51B

MGI Mouse Phenotypes related to Uterine Benign Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.11 ESR1 GNRH1 HOXA10 HPSE2 MED12 MFN2
2 mortality/aging MP:0010768 10.07 CD3E ESR1 FH HPSE2 MED12 MFN2
3 digestive/alimentary MP:0005381 9.95 ESR1 GNRH1 HOXA10 HPSE2 PTEN TGFB3
4 limbs/digits/tail MP:0005371 9.87 ESR1 HOXA10 MED12 PGR PTEN TGFB3
5 neoplasm MP:0002006 9.7 AMH CD3E ESR1 GNRH1 PGR PTEN
6 normal MP:0002873 9.56 ESR1 GNRH1 MED12 MFN2 PGR PTEN
7 skeleton MP:0005390 9.28 ESR1 GNRH1 HOXA10 MED12 MFN2 PGR

Drugs & Therapeutics for Uterine Benign Neoplasm

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Therapeutic Efficacy of High-intensity Focused Ultrasound in the Treatment of Uterine Fibroid Completed NCT02954744

Search NIH Clinical Center for Uterine Benign Neoplasm

Genetic Tests for Uterine Benign Neoplasm

Anatomical Context for Uterine Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Uterine Benign Neoplasm:

19
Uterus

MalaCards organs/tissues related to Uterine Benign Neoplasm:

41
Uterus

Publications for Uterine Benign Neoplasm

Variations for Uterine Benign Neoplasm

Expression for Uterine Benign Neoplasm

Search GEO for disease gene expression data for Uterine Benign Neoplasm.

Pathways for Uterine Benign Neoplasm

Pathways related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.38 TP53 TGFB3 PTEN FH ESR1
2
Show member pathways
12.02 TP53 TGFB3 PTEN PGR ESR1
3 11.57 TP53 MED12 ESR1
4 11.26 TP53 TNRC6B PTEN
5 10.37 TP53 PTEN ESR1

GO Terms for Uterine Benign Neoplasm

Biological processes related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.88 TP53 TGFB3 MED12 HMGA2 ESR1
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.8 TP53 TGFB3 PGR MED12 HOXA10 HMGA2
3 regulation of apoptotic process GO:0042981 9.71 TP53 TGFB3 ESR1 CD3E
4 negative regulation of gene expression GO:0010629 9.67 TNRC6B PGR ESR1 CD3E
5 uterus development GO:0060065 9.46 HOXA10 ESR1
6 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.32 TP53 ESR1
7 aging GO:0007568 9.26 TGFB3 PTEN GNRH1 AMH
8 embryonic neurocranium morphogenesis GO:0048702 9.16 TGFB3 MED12
9 intracellular steroid hormone receptor signaling pathway GO:0030518 9.13 ESR1
10 positive regulation of gene expression GO:0010628 9.1 TP53 TNRC6B PTEN HMGA2 CD3E AMH

Molecular functions related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.02 TP53 PGR HOXA10 HMGA2 ESR1

Sources for Uterine Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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