MCID: UTR031
MIFTS: 30

Uterine Benign Neoplasm

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Uterine Benign Neoplasm

MalaCards integrated aliases for Uterine Benign Neoplasm:

Name: Uterine Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060095

Summaries for Uterine Benign Neoplasm

Disease Ontology : 12 A female reproductive organ benign neoplasm that is located in the uterus.

MalaCards based summary : Uterine Benign Neoplasm is related to endometrial hyperplasia and leiomyoma, uterine. An important gene associated with Uterine Benign Neoplasm is HPSE2 (Heparanase 2 (Inactive)), and among its related pathways/superpathways are Pathways in cancer and Gastric cancer. Affiliated tissues include uterus, breast and ovary, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and Increased TP53 mRNA expression

Related Diseases for Uterine Benign Neoplasm

Diseases related to Uterine Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 213)
# Related Disease Score Top Affiliating Genes
1 endometrial hyperplasia 32.3 TP53 PTEN PGR HOXA10 ESR2 ESR1
2 leiomyoma, uterine 31.5 TMSB15A PGR MIR146A MED12 IGF1 HPSE2
3 uterine corpus adenomatoid tumor 11.3
4 endometrial stromal nodule 11.3
5 uterine corpus bizarre leiomyoma 11.3
6 uterine corpus adenofibroma 11.3
7 uterine corpus leiomyomatosis 11.3
8 uterine corpus cellular leiomyoma 11.3
9 glassy cell carcinoma of the cervix 10.7 PGR ESR1
10 bartholin's gland adenoid cystic carcinoma 10.7 PGR ESR1
11 chronic tympanitis 10.7 PGR ESR1
12 infertility due to extratesticular cause 10.7 GNRH1 ESR1
13 granulomatous endometritis 10.7 PGR ESR1
14 subserous uterine fibroid 10.7 PGR AMH
15 breast juvenile papillomatosis 10.7 PGR ESR1
16 lung leiomyoma 10.7 PGR ESR1
17 vulvar syringoma 10.7 PGR ESR1
18 diffuse peritoneal leiomyomatosis 10.7 PGR MED12 FH
19 trigonitis 10.7 PGR ESR1
20 peritoneal benign neoplasm 10.7 PGR MED12 FH
21 breast duct papilloma 10.7 PTEN PGR
22 breast scirrhous carcinoma 10.7 PGR ESR1
23 oncocytic breast carcinoma 10.7 PGR ESR1
24 vagina leiomyosarcoma 10.7 PGR ESR1
25 breast leiomyoma 10.7 PGR FH ESR1
26 mucinous adenocarcinoma 10.7 TP53 PGR ESR1
27 adult type testicular granulosa cell tumor 10.7 PGR ESR1
28 breast papillary carcinoma 10.7 PGR ESR1
29 bartholin's gland adenoma 10.6 TP53 PGR ESR1
30 bartholin's gland benign neoplasm 10.6 TP53 PGR ESR1
31 vestibular gland benign neoplasm 10.6 TP53 PGR ESR1
32 vulvar leiomyoma 10.6 PGR HMGA2 ESR1
33 nonmucinous bronchioloalveolar adenocarcinoma 10.6 ESR2 ESR1
34 breast neuroendocrine neoplasm 10.6 PGR GNRH1 ESR1
35 ovarian seromucinous carcinoma 10.6 TP53 PGR ESR1
36 carcinosarcoma 10.6 TP53 PTEN PGR
37 vulvar benign neoplasm 10.6 PGR HMGA2 ESR1
38 comedo carcinoma 10.6 TP53 PGR ESR1
39 postmenopausal atrophic vaginitis 10.6 GNRH1 ESR1 CYP19A1
40 juvenile nasopharyngeal angiofibroma 10.6 PGR ESR1 CYP19A1
41 benign metastasizing leiomyoma 10.6 PGR CYP19A1
42 endosalpingiosis 10.6 TP53 PGR ESR1
43 atrophy of prostate 10.6 TP53 GNRH1 EPPIN
44 breast sarcoma 10.6 TP53 PGR ESR1
45 luteoma 10.6 GNRH1 EPPIN CYP19A1
46 intraductal breast neoplasm 10.6 TP53 PGR ESR1
47 apocrine adenosis of breast 10.6 TP53 PGR
48 ovarian benign neoplasm 10.6 TP53 GNRH1 EPPIN
49 microglandular adenosis 10.6 TP53 PGR ESR1
50 skin lipoma 10.6 PTEN HMGA2

Graphical network of the top 20 diseases related to Uterine Benign Neoplasm:



Diseases related to Uterine Benign Neoplasm

Symptoms & Phenotypes for Uterine Benign Neoplasm

GenomeRNAi Phenotypes related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.26 ESR1 ESR2 FH PTEN
2 Increased TP53 mRNA expression GR00389-S-6 8.8 ESR2 HMGA2 TP53

MGI Mouse Phenotypes related to Uterine Benign Neoplasm:

45 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.31 AMH CYP19A1 ESR1 ESR2 FH GNRH1
2 cardiovascular system MP:0005385 10.3 CYP19A1 ESR1 ESR2 HOXA10 IGF1 MED12
3 cellular MP:0005384 10.29 CYP19A1 ESR1 ESR2 FH IGF1 MED12
4 growth/size/body region MP:0005378 10.29 CYP19A1 ESR1 ESR2 GNRH1 HOXA10 HPSE2
5 endocrine/exocrine gland MP:0005379 10.26 AMH CYP19A1 ESR1 ESR2 GNRH1 HOXA10
6 digestive/alimentary MP:0005381 10.14 CYP19A1 ESR1 ESR2 GNRH1 HOXA10 HPSE2
7 integument MP:0010771 10.13 CYP19A1 ESR1 ESR2 GNRH1 IGF1 PGR
8 adipose tissue MP:0005375 10.11 CYP19A1 ESR1 ESR2 HOXA10 IGF1 PTEN
9 limbs/digits/tail MP:0005371 10.06 ESR1 ESR2 HOXA10 IGF1 MED12 PGR
10 nervous system MP:0003631 10.06 CYP19A1 ESR1 ESR2 GNRH1 HOXA10 IGF1
11 neoplasm MP:0002006 10.02 AMH ESR1 ESR2 GNRH1 IGF1 PGR
12 muscle MP:0005369 10.01 CYP19A1 ESR1 ESR2 IGF1 MFN2 PGR
13 normal MP:0002873 10 CYP19A1 ESR1 ESR2 GNRH1 IGF1 MED12
14 liver/biliary system MP:0005370 9.98 CYP19A1 ESR1 ESR2 GNRH1 PTEN TP53
15 renal/urinary system MP:0005367 9.85 CYP19A1 ESR1 ESR2 FH GNRH1 HPSE2
16 reproductive system MP:0005389 9.7 AMH CYP19A1 ESR1 ESR2 GNRH1 HOXA10
17 skeleton MP:0005390 9.36 CYP19A1 ESR1 ESR2 GNRH1 HOXA10 IGF1

Drugs & Therapeutics for Uterine Benign Neoplasm

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Therapeutic Efficacy of High-intensity Focused Ultrasound in the Treatment of Uterine Fibroid Completed NCT02954744

Search NIH Clinical Center for Uterine Benign Neoplasm

Genetic Tests for Uterine Benign Neoplasm

Anatomical Context for Uterine Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Uterine Benign Neoplasm:

19
Uterus

MalaCards organs/tissues related to Uterine Benign Neoplasm:

40
Breast, Uterus, Ovary, Tongue, Bone, Thyroid, Skin

Publications for Uterine Benign Neoplasm

Variations for Uterine Benign Neoplasm

Expression for Uterine Benign Neoplasm

Search GEO for disease gene expression data for Uterine Benign Neoplasm.

Pathways for Uterine Benign Neoplasm

Pathways related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1 12.66 TP53 PTEN IGF1 FH ESR2 ESR1
2
Show member pathways
12.47 TP53 PTEN PGR IGF1 ESR2 ESR1
3 12.4 TP53 PTEN MIR18A MIR146A HMGA2
4 12.38 TSC2 PTEN MFN2 FH CYP19A1
5
Show member pathways
12.24 TSC2 TP53 PTEN IGF1
6
Show member pathways
12.23 TSC2 TP53 PTEN IGF1 ESR2 ESR1
7 12.16 TP53 IGF1 HPSE2 ESR1
8 12.11 TP53 IGF1 HOXA10 HMGA2
9
Show member pathways
12.02 TSC2 TP53 PTEN MIR18A IGF1
10 11.78 TSC2 TP53 MED12 ESR1
11
Show member pathways
11.71 PGR ESR2 ESR1
12 11.71 TSC2 TP53 PTEN IGF1
13 11.67 TSC2 TP53 PTEN
14 11.54 TSC2 TP53 PTEN ESR1 CYP19A1
15 11.32 TSC2 TP53 ESR1
16 11.22 TP53 PTEN ESR1
17 11.11 PGR ESR2 CYP19A1
18 9.4 ESR2 ESR1 CYP19A1

GO Terms for Uterine Benign Neoplasm

Biological processes related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.02 TP53 PGR MED12 IGF1 HOXA10 HMGA2
2 negative regulation of apoptotic process GO:0043066 9.96 TP53 PTEN IGF1 HMGA2 GNRH1
3 heart development GO:0007507 9.85 TSC2 TP53 PTEN MED12
4 positive regulation of transcription, DNA-templated GO:0045893 9.85 TP53 MED12 IGF1 HMGA2 ESR2 ESR1
5 cell-cell signaling GO:0007267 9.83 PGR GNRH1 ESR2 AMH
6 negative regulation of gene expression GO:0010629 9.65 TP53 PGR MIR146A IGF1 ESR1
7 negative regulation of protein kinase B signaling GO:0051898 9.63 TSC2 PTEN MIR146A
8 positive regulation of gene expression GO:0010628 9.63 TP53 PTEN MIR146A IGF1 HMGA2 AMH
9 insulin-like growth factor receptor signaling pathway GO:0048009 9.57 TSC2 IGF1
10 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.54 TP53 ESR1
11 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.51 TP53 ESR1
12 protein kinase B signaling GO:0043491 9.5 TSC2 PTEN IGF1
13 regulation of toll-like receptor signaling pathway GO:0034121 9.49 MIR146A ESR1
14 prostate gland growth GO:0060736 9.43 PTEN CYP19A1
15 negative regulation of mitophagy GO:1901525 9.4 TSC2 TP53
16 uterus development GO:0060065 9.13 HOXA10 ESR1 CYP19A1
17 transcription initiation from RNA polymerase II promoter GO:0006367 9.02 PTEN PGR MED12 ESR2 ESR1

Molecular functions related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.83 TP53 PGR HOXA10 HMGA2 ESR1
2 enzyme binding GO:0019899 9.77 TP53 PTEN PGR ESR2 ESR1
3 steroid hormone receptor activity GO:0003707 9.58 PGR ESR2 ESR1
4 nuclear receptor activity GO:0004879 9.43 PGR ESR2 ESR1
5 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.43 TP53 PGR HOXA10 HMGA2 ESR2 ESR1
6 estrogen receptor activity GO:0030284 9.32 ESR2 ESR1
7 estrogen response element binding GO:0034056 9.16 ESR2 ESR1
8 steroid binding GO:0005496 8.8 PGR ESR2 ESR1

Sources for Uterine Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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