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MCID: UTR031
MIFTS: 32

Uterine Benign Neoplasm

Categories: Cancer diseases, Reproductive diseases
Genes Tissues Related diseases Pathways
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Aliases & Classifications for Uterine Benign Neoplasm

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MalaCards integrated aliases for Uterine Benign Neoplasm:

Name: Uterine Benign Neoplasm 12 15

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0060095
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Summaries for Uterine Benign Neoplasm

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Disease Ontology : 12 A female reproductive organ benign neoplasm that is located in the uterus.

MalaCards based summary : Uterine Benign Neoplasm is related to leiomyoma, uterine and endometrial hyperplasia. An important gene associated with Uterine Benign Neoplasm is HPSE2 (Heparanase 2 (Inactive)), and among its related pathways/superpathways are Phospholipase-C Pathway and Endometrial cancer. Affiliated tissues include the uterus and uterus, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and Increased TP53 mRNA expression

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Related Diseases for Uterine Benign Neoplasm

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Diseases related to Uterine Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 leiomyoma, uterine 31.7 ESR1 FH HMGA2 PGR RAD51B
2 endometrial hyperplasia 11.2
3 uterine corpus adenomatoid tumor 11.2
4 endometrial stromal nodule 11.2
5 uterine corpus bizarre leiomyoma 11.2
6 uterine corpus adenofibroma 11.2
7 uterine corpus leiomyomatosis 11.2
8 vestibular gland benign neoplasm 10.5 ESR1 PGR
9 bartholin's gland adenoma 10.5 ESR1 PGR
10 breast duct papilloma 10.5 PGR PTEN
11 vulvar syringoma 10.5 ESR1 PGR
12 lung leiomyoma 10.5 ESR1 PGR
13 glassy cell carcinoma of the cervix 10.4 ESR1 PGR
14 vulvar benign neoplasm 10.4 ESR1 PGR
15 trigonitis 10.4 ESR1 PGR
16 vulvar leiomyoma 10.4 ESR1 PGR
17 endometrium carcinoma in situ 10.4 PGR TP53
18 pleomorphic lipoma 10.4 HMGA2 PGR
19 breast medullary carcinoma 10.4 ESR1 PGR
20 breast scirrhous carcinoma 10.4 ESR1 PGR
21 skin lipoma 10.4 HMGA2 PTEN
22 bartholin's gland benign neoplasm 10.4 ESR1 PGR
23 bizarre leiomyoma 10.4 MED12 PGR
24 peritoneal benign neoplasm 10.4 ESR1 MED12 PGR
25 diffuse peritoneal leiomyomatosis 10.4 ESR1 MED12 PGR
26 oncocytic breast carcinoma 10.4 ESR1 PGR
27 smooth muscle tumor 10.3 ESR1 HMGA2 PGR
28 cervical carcinosarcoma 10.3 ESR1 PGR TP53
29 glycogen-rich clear cell breast carcinoma 10.3 ESR1 PGR TP53
30 juvenile nasopharyngeal angiofibroma 10.3 ESR1 PGR TGFB3
31 adenosarcoma 10.3 ESR1 PGR TP53
32 carcinosarcoma 10.3 PGR PTEN TP53
33 pre-malignant neoplasm 10.3 ESR1 PGR TP53
34 fallopian tube carcinoma 10.3 ESR1 PGR TP53
35 vulvar adenocarcinoma 10.3 RB1 TP53
36 in situ carcinoma 10.3 ESR1 PGR TP53
37 endometrial squamous cell carcinoma 10.3 ESR1 PGR
38 breast carcinoma in situ 10.3 ESR1 PGR TP53
39 malignant ovarian surface epithelial-stromal neoplasm 10.3 ESR1 PGR TP53
40 ovary epithelial cancer 10.3 ESR1 PGR TP53
41 female breast cancer 10.3 ESR1 PGR TP53
42 progesterone-receptor positive breast cancer 10.3 ESR1 ESR2 PGR
43 cervical adenocarcinoma 10.3 ESR1 PGR TP53
44 progesterone resistance 10.3 ESR1 ESR2 PGR
45 estrogen-receptor positive breast cancer 10.3 ESR1 PGR TP53
46 cribriform carcinoma 10.3 ESR1 PGR
47 gender identity disorder 10.3 ESR1 ESR2 PGR
48 sweat gland cancer 10.3 ESR1 PGR TP53
49 ductal carcinoma in situ 10.3 ESR1 PGR TP53
50 estrogen excess 10.3 ESR1 ESR2 PGR

Graphical network of the top 20 diseases related to Uterine Benign Neoplasm:



Diseases related to Uterine Benign Neoplasm
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Symptoms & Phenotypes for Uterine Benign Neoplasm

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GenomeRNAi Phenotypes related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.35 ESR1 ESR2 FH PTEN RAD51B
2 Increased TP53 mRNA expression GR00389-S-6 8.8 ESR2 HMGA2 TP53

MGI Mouse Phenotypes related to Uterine Benign Neoplasm:

47 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.36 CD3E ESR1 ESR2 FH IGF1 MED12
2 endocrine/exocrine gland MP:0005379 10.34 CD3E ESR1 ESR2 GNRH1 HOXA10 IGF1
3 mortality/aging MP:0010768 10.33 CD3E ESR1 ESR2 FH HPSE2 IGF1
4 cardiovascular system MP:0005385 10.29 ESR1 ESR2 IGF1 MED12 PAX2 PGR
5 growth/size/body region MP:0005378 10.29 ESR1 ESR2 GNRH1 HOXA10 HPSE2 IGF1
6 homeostasis/metabolism MP:0005376 10.26 ESR1 ESR2 FH GNRH1 HPSE2 IGF1
7 hematopoietic system MP:0005397 10.24 CD3E ESR1 ESR2 GNRH1 IGF1 PGR
8 digestive/alimentary MP:0005381 10.23 ESR1 ESR2 GNRH1 HOXA10 HPSE2 PTEN
9 immune system MP:0005387 10.21 CD3E ESR1 ESR2 GNRH1 IGF1 PGR
10 limbs/digits/tail MP:0005371 10.18 ESR1 ESR2 HOXA10 IGF1 MED12 PGR
11 embryo MP:0005380 10.17 ESR1 MED12 PAX2 PGR PTEN RB1
12 integument MP:0010771 10.15 CD3E ESR1 ESR2 GNRH1 IGF1 PGR
13 nervous system MP:0003631 10.15 CD3E ESR1 ESR2 GNRH1 HOXA10 IGF1
14 adipose tissue MP:0005375 10.08 ESR1 ESR2 IGF1 PTEN RB1 TP53
15 neoplasm MP:0002006 10.06 CD3E ESR1 ESR2 GNRH1 IGF1 PGR
16 normal MP:0002873 10.02 ESR1 ESR2 GNRH1 IGF1 MED12 PGR
17 muscle MP:0005369 9.98 ESR1 ESR2 IGF1 PGR PTEN RB1
18 renal/urinary system MP:0005367 9.96 ESR1 ESR2 FH GNRH1 HPSE2 IGF1
19 reproductive system MP:0005389 9.9 ESR1 ESR2 GNRH1 HOXA10 IGF1 PAX2
20 respiratory system MP:0005388 9.5 ESR1 ESR2 IGF1 PTEN RB1 TGFB3
21 skeleton MP:0005390 9.36 ESR1 ESR2 GNRH1 HOXA10 IGF1 MED12
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Drugs & Therapeutics for Uterine Benign Neoplasm

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 High-intensity Focused Ultrasound in Treatment of Uterine Fibroid Completed NCT02954744 Not Applicable

Search NIH Clinical Center for Uterine Benign Neoplasm

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Genetic Tests for Uterine Benign Neoplasm

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Anatomical Context for Uterine Benign Neoplasm

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The Foundational Model of Anatomy Ontology organs/tissues related to Uterine Benign Neoplasm:

20
The Uterus

MalaCards organs/tissues related to Uterine Benign Neoplasm:

42
Uterus
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Publications for Uterine Benign Neoplasm

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Variations for Uterine Benign Neoplasm

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Expression for Uterine Benign Neoplasm

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Search GEO for disease gene expression data for Uterine Benign Neoplasm.
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Pathways for Uterine Benign Neoplasm

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Pathways related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Phospholipase-C Pathway 65
Show member pathways
 12.92 CD3E GNRH1 IGF1 PTEN TGFB3 TP53
2
Endometrial cancer 38
Show member pathways
 12.73 IGF1 PTEN RB1 TGFB3 TP53
3
Chks in Checkpoint Regulation 65
Show member pathways
 12.56 ESR1 ESR2 IGF1 RB1 TP53
4
Glioma 38
Show member pathways
 12.33 ESR1 ESR2 IGF1 PTEN RB1 TP53
5
Pathways in cancer 38
12.28 ESR1 ESR2 FH IGF1 PTEN RB1
6
DNA Damage Response 1
Show member pathways
 12.24 IGF1 PTEN RB1 TP53
7
Human T-cell leukemia virus 1 infection 38
12.22 CD3E RB1 TGFB3 TP53
8
Proteoglycans in cancer 38
12.14 ESR1 HPSE2 IGF1 TP53
9
Transcriptional misregulation in cancer 38
12.09 HMGA2 HOXA10 IGF1 TP53
10
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.04 GNRH1 IGF1 RB1 TGFB3 TP53
11
Cellular senescence (KEGG) 38
12 PTEN RB1 TGFB3 TP53
12
Integrated Breast Cancer Pathway 1
11.97 ESR1 PTEN RB1 TP53
13
Gastric cancer 38
Show member pathways
 11.89 ESR1 ESR2 IGF1 PGR PTEN RB1
14
TGF-beta Signaling Pathways 66
11.76 ESR1 ESR2 TGFB3
15
Small cell lung cancer 38
11.74 PTEN RB1 TP53
16
Nuclear Receptor transcription pathway 67
Show member pathways
 11.71 ESR1 ESR2 PGR
17
Glioblastoma Multiforme 65
11.71 IGF1 PTEN RB1 TP53
18
Senescence and Autophagy in Cancer 1
11.65 IGF1 PTEN RB1 TP53
19
G-protein signaling_RhoA regulation pathway 23
11.6 CD3E GNRH1 IGF1 TGFB3
20
Integrated Cancer Pathway 1
11.35 PTEN RB1 TP53
21
Ovarian tumor domain proteases 67
11.15 ESR1 PTEN TP53
22
ID signaling pathway 1
10.82 PAX2 RB1
23
MNAR-PELP1 and Estrogen Receptor Interaction 65
10.69 ESR1 ESR2 RB1
24
Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics 62
10.06 ESR1 ESR2
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GO Terms for Uterine Benign Neoplasm

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Cellular components related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 PML body GO:0016605 8.8 PTEN RB1 TP53

Biological processes related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.99 HPSE2 IGF1 PAX2 PTEN TGFB3
2 negative regulation of cell proliferation GO:0008285 9.93 GNRH1 PTEN RB1 TGFB3 TP53
3 positive regulation of gene expression GO:0010628 9.91 CD3E HMGA2 IGF1 PTEN TP53
4 regulation of apoptotic process GO:0042981 9.88 CD3E ESR1 TGFB3 TP53
5 negative regulation of apoptotic process GO:0043066 9.85 GNRH1 HMGA2 IGF1 PAX2 PTEN TP53
6 aging GO:0007568 9.8 GNRH1 PAX2 PTEN TGFB3
7 positive regulation of DNA-binding transcription factor activity GO:0051091 9.79 ESR1 ESR2 PTEN
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.75 CD3E IGF1 TP53
9 Ras protein signal transduction GO:0007265 9.73 IGF1 RB1 TP53
10 transcription initiation from RNA polymerase II promoter GO:0006367 9.73 ESR1 ESR2 MED12 PGR
11 positive regulation of fibroblast proliferation GO:0048146 9.65 ESR1 IGF1 S100A6
12 negative regulation of gene expression GO:0010629 9.65 CD3E ESR1 IGF1 PGR RB1
13 positive regulation of transcription by RNA polymerase II GO:0045944 9.65 ESR1 HMGA2 HOXA10 IGF1 MED12 PAX2
14 intracellular steroid hormone receptor signaling pathway GO:0030518 9.61 ESR1 MED12
15 transcription by RNA polymerase II GO:0006366 9.6 ESR1 PAX2
16 protein kinase B signaling GO:0043491 9.58 IGF1 PAX2 PTEN
17 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.57 ESR1 TP53
18 transcription, DNA-templated GO:0006351 9.55 ESR1 PAX2
19 embryonic neurocranium morphogenesis GO:0048702 9.52 MED12 TGFB3
20 stem cell differentiation GO:0048863 9.5 ESR1 HMGA2 PAX2
21 positive regulation of transcription regulatory region DNA binding GO:2000679 9.33 HMGA2 IGF1 RB1
22 positive regulation of transcription, DNA-templated GO:0045893 9.28 ESR1 ESR2 HMGA2 IGF1 MED12 PAX2
23 regulation of transcription, DNA-templated GO:0006355 10.06 ESR1 ESR2 HMGA2 HOXA10 PAX2 PGR

Molecular functions related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 lipid binding GO:0008289 9.81 ESR1 ESR2 PGR PTEN
2 steroid hormone receptor activity GO:0003707 9.65 ESR1 ESR2 PGR
3 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.63 ESR1 ESR2 HMGA2 HOXA10 PGR TP53
4 nuclear receptor activity GO:0004879 9.58 ESR1 ESR2 PGR
5 estrogen receptor activity GO:0030284 9.43 ESR1 ESR2
6 steroid binding GO:0005496 9.43 ESR1 ESR2 PGR
7 enzyme binding GO:0019899 9.43 ESR1 ESR2 PGR PTEN RB1 TP53
8 estrogen response element binding GO:0034056 9.37 ESR1 ESR2
9 transcription factor binding GO:0008134 9.1 ESR1 HMGA2 MED12 PAX2 RB1 TP53
10 protein binding GO:0005515 10.25 CD3E ESR1 ESR2 FH HMGA2 HOXA10
11 DNA binding GO:0003677 10.15 ESR1 ESR2 HMGA2 HOXA10 PAX2 PGR
12 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 10.07 ESR1 ESR2 HMGA2 HOXA10 PAX2 PGR
13 identical protein binding GO:0042802 10 ESR1 ESR2 PGR PTEN RB1 TGFB3
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Sources for Uterine Benign Neoplasm

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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