Uterine Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: UTR031 MIFTS: 30	Uterine Benign Neoplasm Categories: Cancer diseases, Reproductive diseases
Genes Tissues Related diseases Pathways Expand all tables

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Aliases & Classifications for Uterine Benign Neoplasm

MalaCards integrated aliases for Uterine Benign Neoplasm:

Name: Uterine Benign Neoplasm ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060095

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Summaries for Uterine Benign Neoplasm

Disease Ontology : ¹² A female reproductive organ benign neoplasm that is located in the uterus.

MalaCards based summary : Uterine Benign Neoplasm is related to endometrial hyperplasia and leiomyoma, uterine. An important gene associated with Uterine Benign Neoplasm is HPSE2 (Heparanase 2 (Inactive)), and among its related pathways/superpathways are Pathways in cancer and Gastric cancer. Affiliated tissues include uterus, breast and ovary, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and Increased TP53 mRNA expression

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Related Diseases for Uterine Benign Neoplasm

Diseases related to Uterine Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 213)

#	Related Disease	Score	Top Affiliating Genes
1	endometrial hyperplasia	32.3	TP53 PTEN PGR HOXA10 ESR2 ESR1
2	leiomyoma, uterine	31.5	TMSB15A PGR MIR146A MED12 IGF1 HPSE2
3	uterine corpus adenomatoid tumor	11.3
4	endometrial stromal nodule	11.3
5	uterine corpus bizarre leiomyoma	11.3
6	uterine corpus adenofibroma	11.3
7	uterine corpus leiomyomatosis	11.3
8	uterine corpus cellular leiomyoma	11.3
9	glassy cell carcinoma of the cervix	10.7	PGR ESR1
10	bartholin's gland adenoid cystic carcinoma	10.7	PGR ESR1
11	chronic tympanitis	10.7	PGR ESR1
12	infertility due to extratesticular cause	10.7	GNRH1 ESR1
13	granulomatous endometritis	10.7	PGR ESR1
14	subserous uterine fibroid	10.7	PGR AMH
15	breast juvenile papillomatosis	10.7	PGR ESR1
16	lung leiomyoma	10.7	PGR ESR1
17	vulvar syringoma	10.7	PGR ESR1
18	diffuse peritoneal leiomyomatosis	10.7	PGR MED12 FH
19	trigonitis	10.7	PGR ESR1
20	peritoneal benign neoplasm	10.7	PGR MED12 FH
21	breast duct papilloma	10.7	PTEN PGR
22	breast scirrhous carcinoma	10.7	PGR ESR1
23	oncocytic breast carcinoma	10.7	PGR ESR1
24	vagina leiomyosarcoma	10.7	PGR ESR1
25	breast leiomyoma	10.7	PGR FH ESR1
26	mucinous adenocarcinoma	10.7	TP53 PGR ESR1
27	adult type testicular granulosa cell tumor	10.7	PGR ESR1
28	breast papillary carcinoma	10.7	PGR ESR1
29	bartholin's gland adenoma	10.6	TP53 PGR ESR1
30	bartholin's gland benign neoplasm	10.6	TP53 PGR ESR1
31	vestibular gland benign neoplasm	10.6	TP53 PGR ESR1
32	vulvar leiomyoma	10.6	PGR HMGA2 ESR1
33	nonmucinous bronchioloalveolar adenocarcinoma	10.6	ESR2 ESR1
34	breast neuroendocrine neoplasm	10.6	PGR GNRH1 ESR1
35	ovarian seromucinous carcinoma	10.6	TP53 PGR ESR1
36	carcinosarcoma	10.6	TP53 PTEN PGR
37	vulvar benign neoplasm	10.6	PGR HMGA2 ESR1
38	comedo carcinoma	10.6	TP53 PGR ESR1
39	postmenopausal atrophic vaginitis	10.6	GNRH1 ESR1 CYP19A1
40	juvenile nasopharyngeal angiofibroma	10.6	PGR ESR1 CYP19A1
41	benign metastasizing leiomyoma	10.6	PGR CYP19A1
42	endosalpingiosis	10.6	TP53 PGR ESR1
43	atrophy of prostate	10.6	TP53 GNRH1 EPPIN
44	breast sarcoma	10.6	TP53 PGR ESR1
45	luteoma	10.6	GNRH1 EPPIN CYP19A1
46	intraductal breast neoplasm	10.6	TP53 PGR ESR1
47	apocrine adenosis of breast	10.6	TP53 PGR
48	ovarian benign neoplasm	10.6	TP53 GNRH1 EPPIN
49	microglandular adenosis	10.6	TP53 PGR ESR1
50	skin lipoma	10.6	PTEN HMGA2

Graphical network of the top 20 diseases related to Uterine Benign Neoplasm:

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Symptoms & Phenotypes for Uterine Benign Neoplasm

GenomeRNAi Phenotypes related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)	GR00104-A-0	9.26	ESR1 ESR2 FH PTEN
2	Increased TP53 mRNA expression	GR00389-S-6	8.8	ESR2 HMGA2 TP53

MGI Mouse Phenotypes related to Uterine Benign Neoplasm:

⁴⁵ (show all 17)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.31	AMH CYP19A1 ESR1 ESR2 FH GNRH1
2	cardiovascular system	MP:0005385	10.3	CYP19A1 ESR1 ESR2 HOXA10 IGF1 MED12
3	cellular	MP:0005384	10.29	CYP19A1 ESR1 ESR2 FH IGF1 MED12
4	growth/size/body region	MP:0005378	10.29	CYP19A1 ESR1 ESR2 GNRH1 HOXA10 HPSE2
5	endocrine/exocrine gland	MP:0005379	10.26	AMH CYP19A1 ESR1 ESR2 GNRH1 HOXA10
6	digestive/alimentary	MP:0005381	10.14	CYP19A1 ESR1 ESR2 GNRH1 HOXA10 HPSE2
7	integument	MP:0010771	10.13	CYP19A1 ESR1 ESR2 GNRH1 IGF1 PGR
8	adipose tissue	MP:0005375	10.11	CYP19A1 ESR1 ESR2 HOXA10 IGF1 PTEN
9	limbs/digits/tail	MP:0005371	10.06	ESR1 ESR2 HOXA10 IGF1 MED12 PGR
10	nervous system	MP:0003631	10.06	CYP19A1 ESR1 ESR2 GNRH1 HOXA10 IGF1
11	neoplasm	MP:0002006	10.02	AMH ESR1 ESR2 GNRH1 IGF1 PGR
12	muscle	MP:0005369	10.01	CYP19A1 ESR1 ESR2 IGF1 MFN2 PGR
13	normal	MP:0002873	10	CYP19A1 ESR1 ESR2 GNRH1 IGF1 MED12
14	liver/biliary system	MP:0005370	9.98	CYP19A1 ESR1 ESR2 GNRH1 PTEN TP53
15	renal/urinary system	MP:0005367	9.85	CYP19A1 ESR1 ESR2 FH GNRH1 HPSE2
16	reproductive system	MP:0005389	9.7	AMH CYP19A1 ESR1 ESR2 GNRH1 HOXA10
17	skeleton	MP:0005390	9.36	CYP19A1 ESR1 ESR2 GNRH1 HOXA10 IGF1

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Drugs & Therapeutics for Uterine Benign Neoplasm

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Therapeutic Efficacy of High-intensity Focused Ultrasound in the Treatment of Uterine Fibroid	Completed	NCT02954744

Search NIH Clinical Center for Uterine Benign Neoplasm

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Genetic Tests for Uterine Benign Neoplasm

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Anatomical Context for Uterine Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Uterine Benign Neoplasm:

¹⁹

Uterus

MalaCards organs/tissues related to Uterine Benign Neoplasm:

⁴⁰

Breast, Uterus, Ovary, Tongue, Bone, Thyroid, Skin

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Publications for Uterine Benign Neoplasm

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Genes for Uterine Benign Neoplasm

Genes related to Uterine Benign Neoplasm (0 elite genes):

(show all 40)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	HPSE2	Heparanase 2 (Inactive)	Protein Coding	8.9	DISEASES inferred ¹⁵
2	PGR	Progesterone Receptor	Protein Coding	8.57	DISEASES inferred ¹⁵
3	MED12	Mediator Complex Subunit 12	Protein Coding	8.32	DISEASES inferred ¹⁵
4	FH	Fumarate Hydratase	Protein Coding	8.31	DISEASES inferred ¹⁵
5	EPPIN	Epididymal Peptidase Inhibitor	Protein Coding	8.25	DISEASES inferred ¹⁵ ¹⁵
6	GNRH1	Gonadotropin Releasing Hormone 1	Protein Coding	7.97	DISEASES inferred ¹⁵
7	ESR1	Estrogen Receptor 1	Protein Coding	7.83	DISEASES inferred ¹⁵
8	HMGA2	High Mobility Group AT-Hook 2	Protein Coding	7.61	DISEASES inferred ¹⁵
9	PTEN	Phosphatase And Tensin Homolog	Protein Coding	7.35	DISEASES inferred ¹⁵
10	MIR18A	MicroRNA 18a	RNA Gene	7.22	DISEASES inferred ¹⁵ ¹⁵
11	CYP19A1	Cytochrome P450 Family 19 Subfamily A Member 1	Protein Coding	7.07	DISEASES inferred ¹⁵
12	MIR146A	MicroRNA 146a	RNA Gene	7.03	DISEASES inferred ¹⁵ ¹⁵
13	TP53	Tumor Protein P53	Protein Coding	6.97	DISEASES inferred ¹⁵
14	TMSB15A	Thymosin Beta 15a	Protein Coding	6.96	DISEASES inferred ¹⁵ ¹⁵
15	AMH	Anti-Mullerian Hormone	Protein Coding	6.77	DISEASES inferred ¹⁵
16	HOXA10	Homeobox A10	Protein Coding	6.76	DISEASES inferred ¹⁵
17	MFN2	Mitofusin 2	Protein Coding	6.7	DISEASES inferred ¹⁵
18	ESR2	Estrogen Receptor 2	Protein Coding	6.68	DISEASES inferred ¹⁵
19	TSC2	TSC Complex Subunit 2	Protein Coding	6.68	DISEASES inferred ¹⁵
20	IGF1	Insulin Like Growth Factor 1	Protein Coding	6.64	DISEASES inferred ¹⁵
21	MME	Membrane Metalloendopeptidase	Protein Coding	6.63	DISEASES inferred ¹⁵
22	CALD1	Caldesmon 1	Protein Coding	6.62	DISEASES inferred ¹⁵
23	RAD51B	RAD51 Paralog B	Protein Coding	6.55	DISEASES inferred ¹⁵
24	JAZF1	JAZF Zinc Finger 1	Protein Coding	6.53	DISEASES inferred ¹⁵
25	OXT	Oxytocin/Neurophysin I Prepropeptide	Protein Coding	6.52	DISEASES inferred ¹⁵
26	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	6.48	DISEASES inferred ¹⁵
27	SHBG	Sex Hormone Binding Globulin	Protein Coding	6.43	DISEASES inferred ¹⁵
28	CDK8	Cyclin Dependent Kinase 8	Protein Coding	6.41	DISEASES inferred ¹⁵
29	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	6.34	DISEASES inferred ¹⁵
30	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	6.34	DISEASES inferred ¹⁵
31	CTNNB1	Catenin Beta 1	Protein Coding	6.32	DISEASES inferred ¹⁵
32	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	6.32	DISEASES inferred ¹⁵
33	BET1L	Bet1 Golgi Vesicular Membrane Trafficking Protein Like	Protein Coding	6.32	DISEASES inferred ¹⁵
34	CCNC	Cyclin C	Protein Coding	6.31	DISEASES inferred ¹⁵
35	CD34	CD34 Molecule	Protein Coding	6.26	DISEASES inferred ¹⁵
36	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	6.24	DISEASES inferred ¹⁵
37	CCND1	Cyclin D1	Protein Coding	6.22	DISEASES inferred ¹⁵
38	NDUFB11	NADH:Ubiquinone Oxidoreductase Subunit B11	Protein Coding	6.19	DISEASES inferred ¹⁵
39	PRL	Prolactin	Protein Coding	6.16	DISEASES inferred ¹⁵
40	S100A6	S100 Calcium Binding Protein A6	Protein Coding	6.14	DISEASES inferred ¹⁵

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Variations for Uterine Benign Neoplasm

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Expression for Uterine Benign Neoplasm

Search GEO for disease gene expression data for Uterine Benign Neoplasm.

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Pathways for Uterine Benign Neoplasm

Pathways related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 18)

#	Super pathways	Score	Top Affiliating Genes
1	Pathways in cancer ³⁶	12.66	TP53 PTEN IGF1 FH ESR2 ESR1
2	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	12.47	TP53 PTEN PGR IGF1 ESR2 ESR1
3	MicroRNAs in cancer ³⁶	12.4	TP53 PTEN MIR18A MIR146A HMGA2
4	Glucose / Energy Metabolism ⁴	12.38	TSC2 PTEN MFN2 FH CYP19A1
5	Development IGF-1 receptor signaling ²² Show member pathways IL-4 Signaling Pathway ¹ Immune response IL-4 signaling pathway ²² Signal transduction AKT signaling ²²	12.24	TSC2 TP53 PTEN IGF1
6	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	12.23	TSC2 TP53 PTEN IGF1 ESR2 ESR1
7	Proteoglycans in cancer ³⁶	12.16	TP53 IGF1 HPSE2 ESR1
8	Transcriptional misregulation in cancer ³⁶	12.11	TP53 IGF1 HOXA10 HMGA2
9	DNA Damage Response ¹ Show member pathways miRNA Regulation of DNA Damage Response ¹ p53 signaling pathway ³⁶	12.02	TSC2 TP53 PTEN MIR18A IGF1
10	Thyroid hormone signaling pathway ³⁶	11.78	TSC2 TP53 MED12 ESR1
11	Nuclear Receptor transcription pathway ⁶⁵ Show member pathways Nuclear Receptors ¹	11.71	PGR ESR2 ESR1
12	Glioblastoma Multiforme ⁶³	11.71	TSC2 TP53 PTEN IGF1
13	TP53 Regulates Metabolic Genes ⁶⁵	11.67	TSC2 TP53 PTEN
14	Integrated Breast Cancer Pathway ¹	11.54	TSC2 TP53 PTEN ESR1 CYP19A1
15	LKB1 signaling events ¹	11.32	TSC2 TP53 ESR1
16	Ovarian tumor domain proteases ⁶⁵	11.22	TP53 PTEN ESR1
17	Ovarian Infertility Genes ¹	11.11	PGR ESR2 CYP19A1
18	Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics ⁶⁰	9.4	ESR2 ESR1 CYP19A1

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GO Terms for Uterine Benign Neoplasm

Biological processes related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	10.02	TP53 PGR MED12 IGF1 HOXA10 HMGA2
2	negative regulation of apoptotic process	GO:0043066	9.96	TP53 PTEN IGF1 HMGA2 GNRH1
3	heart development	GO:0007507	9.85	TSC2 TP53 PTEN MED12
4	positive regulation of transcription, DNA-templated	GO:0045893	9.85	TP53 MED12 IGF1 HMGA2 ESR2 ESR1
5	cell-cell signaling	GO:0007267	9.83	PGR GNRH1 ESR2 AMH
6	negative regulation of gene expression	GO:0010629	9.65	TP53 PGR MIR146A IGF1 ESR1
7	negative regulation of protein kinase B signaling	GO:0051898	9.63	TSC2 PTEN MIR146A
8	positive regulation of gene expression	GO:0010628	9.63	TP53 PTEN MIR146A IGF1 HMGA2 AMH
9	insulin-like growth factor receptor signaling pathway	GO:0048009	9.57	TSC2 IGF1
10	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	GO:0045899	9.54	TP53 ESR1
11	negative regulation of production of miRNAs involved in gene silencing by miRNA	GO:1903799	9.51	TP53 ESR1
12	protein kinase B signaling	GO:0043491	9.5	TSC2 PTEN IGF1
13	regulation of toll-like receptor signaling pathway	GO:0034121	9.49	MIR146A ESR1
14	prostate gland growth	GO:0060736	9.43	PTEN CYP19A1
15	negative regulation of mitophagy	GO:1901525	9.4	TSC2 TP53
16	uterus development	GO:0060065	9.13	HOXA10 ESR1 CYP19A1
17	transcription initiation from RNA polymerase II promoter	GO:0006367	9.02	PTEN PGR MED12 ESR2 ESR1

Molecular functions related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	DNA-binding transcription activator activity, RNA polymerase II-specific	GO:0001228	9.83	TP53 PGR HOXA10 HMGA2 ESR1
2	enzyme binding	GO:0019899	9.77	TP53 PTEN PGR ESR2 ESR1
3	steroid hormone receptor activity	GO:0003707	9.58	PGR ESR2 ESR1
4	nuclear receptor activity	GO:0004879	9.43	PGR ESR2 ESR1
5	RNA polymerase II proximal promoter sequence-specific DNA binding	GO:0000978	9.43	TP53 PGR HOXA10 HMGA2 ESR2 ESR1
6	estrogen receptor activity	GO:0030284	9.32	ESR2 ESR1
7	estrogen response element binding	GO:0034056	9.16	ESR2 ESR1
8	steroid binding	GO:0005496	8.8	PGR ESR2 ESR1

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