Uterine Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Uterine Benign Neoplasm

MalaCards integrated aliases for Uterine Benign Neoplasm:

Name: Uterine Benign Neoplasm ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060095

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Summaries for Uterine Benign Neoplasm

MalaCards based summary : Uterine Benign Neoplasm is related to leiomyoma, uterine and bizarre leiomyoma. An important gene associated with Uterine Benign Neoplasm is HPSE2 (Heparanase 2 (Inactive)), and among its related pathways/superpathways is Thyroid hormone signaling pathway. Related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and growth/size/body region

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Related Diseases for Uterine Benign Neoplasm

Diseases related to Uterine Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)

#	Related Disease	Score	Top Affiliating Genes
1	leiomyoma, uterine	11.1
2	bizarre leiomyoma	10.9	MED12 PGR
3	vulvar syringoma	10.9	ESR1 PGR
4	lung leiomyoma	10.9	ESR1 PGR
5	vestibular gland benign neoplasm	10.8	ESR1 PGR
6	bartholin's gland adenoma	10.8	ESR1 PGR
7	glassy cell carcinoma of the cervix	10.8	ESR1 PGR
8	vulvar benign neoplasm	10.8	ESR1 PGR
9	trigonitis	10.8	ESR1 PGR
10	vulvar leiomyoma	10.8	ESR1 PGR
11	breast medullary carcinoma	10.8	ESR1 PGR
12	breast scirrhous carcinoma	10.8	ESR1 PGR
13	progesterone resistance	10.8	ESR1 PGR
14	progesterone-receptor positive breast cancer	10.8	ESR1 PGR
15	cribriform carcinoma	10.8	ESR1 PGR
16	oncocytic breast carcinoma	10.8	ESR1 PGR
17	endometrial squamous cell carcinoma	10.8	ESR1 PGR
18	gastric signet ring cell adenocarcinoma	10.8	ESR1 PGR
19	endometrial mucinous adenocarcinoma	10.8	ESR1 PGR
20	adenoid basal cell carcinoma	10.8	ESR1 PGR
21	apocrine adenocarcinoma	10.8	ESR1 PGR
22	gender identity disorder	10.8	ESR1 PGR
23	bartholin's gland benign neoplasm	10.8	ESR1 PGR
24	deep angioma	10.7	ESR1 PGR
25	synchronous bilateral breast carcinoma	10.7	ESR1 PGR
26	breast adenoid cystic carcinoma	10.7	ESR1 PGR
27	cervical carcinosarcoma	10.7	ESR1 PGR
28	estrogen excess	10.7	ESR1 PGR
29	intramuscular hemangioma	10.7	ESR1 PGR
30	glycogen-rich clear cell breast carcinoma	10.7	ESR1 PGR
31	mammographic density	10.7	ESR1 PGR
32	retinitis pigmentosa 47	10.7	ESR1 PGR
33	uterine corpus cancer	10.6	ESR1 PGR
34	adenomyosis	10.6	ESR1 PGR
35	retinitis pigmentosa 20	10.6	ESR1 PGR
36	luminal breast carcinoma	10.6	ESR1 PGR
37	breast benign neoplasm	10.6	ESR1 MED12 PGR
38	thoracic benign neoplasm	10.6	ESR1 MED12 PGR
39	adenosarcoma	10.6	ESR1 PGR
40	smooth muscle tumor	10.6	ESR1 HMGA2 PGR
41	cervical clear cell adenocarcinoma	10.6	ESR1 PGR
42	leiomyosarcoma	10.5	FH MED12 PGR
43	hereditary renal cell carcinoma	10.5	FH TSC2
44	perivascular epithelioid cell tumor	10.5	PGR TSC2
45	endometriosis of ovary	10.5	ESR1 PGR
46	multilocular clear cell renal cell carcinoma	10.5	TGFB3 TSC2
47	inflammatory breast carcinoma	10.5	ESR1 PGR
48	juvenile nasopharyngeal angiofibroma	10.4	ESR1 PGR TGFB3
49	mixed cell type cancer	10.4	ESR1 PGR
50	breast papillary carcinoma	10.4	ESR1 PGR TSC2

Graphical network of the top 20 diseases related to Uterine Benign Neoplasm:

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Symptoms & Phenotypes for Uterine Benign Neoplasm

GenomeRNAi Phenotypes related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)	GR00104-A-0	8.8	ESR1 FH RAD51B

MGI Mouse Phenotypes related to Uterine Benign Neoplasm:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	9.65	RGS7 TGFB3 TNRC6B TSC2 VCAN CCDC57
2	mortality/aging	MP:0010768	9.4	RAD51B RGS7 TGFB3 TNRC6B TSC2 VCAN

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Drugs & Therapeutics for Uterine Benign Neoplasm

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	High-intensity Focused Ultrasound in Treatment of Uterine Fibroid	Completed	NCT02954744	Not Applicable

Search NIH Clinical Center for Uterine Benign Neoplasm

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Genetic Tests for Uterine Benign Neoplasm

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Anatomical Context for Uterine Benign Neoplasm

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Publications for Uterine Benign Neoplasm

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Genes for Uterine Benign Neoplasm

Genes related to Uterine Benign Neoplasm (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	HPSE2	Heparanase 2 (Inactive)	Protein Coding	18.58	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	MED12	Mediator Complex Subunit 12	Protein Coding	17.31	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	PGR	Progesterone Receptor	Protein Coding	16.91	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	HMGA2	High Mobility Group AT-Hook 2	Protein Coding	16.52	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	RAD51B	RAD51 Paralog B	Protein Coding	16.03	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	ESR1	Estrogen Receptor 1	Protein Coding	15.97	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	FH	Fumarate Hydratase	Protein Coding	15.84	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	TNRC6B	Trinucleotide Repeat Containing 6B	Protein Coding	15.8	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	PRDM10	PR/SET Domain 10	Protein Coding	15.79	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	15.74	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	TSC2	TSC Complex Subunit 2	Protein Coding	15.57	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	RGS7	Regulator Of G Protein Signaling 7	Protein Coding	15.56	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
13	CCDC57	Coiled-Coil Domain Containing 57	Protein Coding	15.38	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
14	VCAN	Versican	Protein Coding	15.32	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
15	IVL	Involucrin	Protein Coding	6.27	DISEASES inferred ¹⁵
16	BET1L	Bet1 Golgi Vesicular Membrane Trafficking Protein Like	Protein Coding	6.14	DISEASES inferred ¹⁵

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Variations for Uterine Benign Neoplasm

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Expression for Uterine Benign Neoplasm

Search GEO for disease gene expression data for Uterine Benign Neoplasm.

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Pathways for Uterine Benign Neoplasm

Pathways related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Thyroid hormone signaling pathway ³⁷	10.86	ESR1 MED12 TSC2

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GO Terms for Uterine Benign Neoplasm

Biological processes related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transcription initiation from RNA polymerase II promoter	GO:0006367	9.43	ESR1 MED12 PGR
2	stem cell differentiation	GO:0048863	9.16	ESR1 HMGA2
3	intracellular steroid hormone receptor signaling pathway	GO:0030518	8.96	ESR1 MED12
4	embryonic neurocranium morphogenesis	GO:0048702	8.62	MED12 TGFB3

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