MCID: UTR031
MIFTS: 26

Uterine Benign Neoplasm

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Uterine Benign Neoplasm

MalaCards integrated aliases for Uterine Benign Neoplasm:

Name: Uterine Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060095

Summaries for Uterine Benign Neoplasm

Disease Ontology : 12 A female reproductive organ benign neoplasm that is located in the uterus.

MalaCards based summary : Uterine Benign Neoplasm is related to leiomyoma, uterine and uterine corpus adenomatoid tumor. An important gene associated with Uterine Benign Neoplasm is HPSE2 (Heparanase 2 (Inactive)), and among its related pathways/superpathways are NF-KappaB Family Pathway and Th1 Differentiation Pathway. Affiliated tissues include uterus, lung and heart, and related phenotypes are mortality/aging and renal/urinary system

Related Diseases for Uterine Benign Neoplasm

Diseases related to Uterine Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 leiomyoma, uterine 31.6 ESR1 FH HMGA2 PGR RAD51B
2 uterine corpus adenomatoid tumor 11.2
3 endometrial stromal nodule 11.2
4 uterine corpus bizarre leiomyoma 11.2
5 uterine corpus adenofibroma 11.2
6 uterine corpus leiomyomatosis 11.2
7 bizarre leiomyoma 10.3 MED12 PGR
8 vestibular gland benign neoplasm 10.3 ESR1 PGR
9 bartholin's gland adenoma 10.3 ESR1 PGR
10 pleomorphic lipoma 10.3 HMGA2 PGR
11 vulvar syringoma 10.3 ESR1 PGR
12 glassy cell carcinoma of the cervix 10.3 ESR1 PGR
13 lung leiomyoma 10.3 ESR1 PGR
14 vulvar benign neoplasm 10.3 ESR1 PGR
15 trigonitis 10.3 ESR1 PGR
16 vulvar leiomyoma 10.3 ESR1 PGR
17 breast medullary carcinoma 10.3 ESR1 PGR
18 breast scirrhous carcinoma 10.3 ESR1 PGR
19 bartholin's gland benign neoplasm 10.3 ESR1 PGR
20 oncocytic breast carcinoma 10.3 ESR1 PGR
21 progesterone-receptor positive breast cancer 10.3 ESR1 PGR
22 progesterone resistance 10.2 ESR1 PGR
23 endometrial squamous cell carcinoma 10.2 ESR1 PGR
24 cribriform carcinoma 10.2 ESR1 PGR
25 endometrial mucinous adenocarcinoma 10.2 ESR1 PGR
26 adenoid basal cell carcinoma 10.2 ESR1 PGR
27 breast adenoid cystic carcinoma 10.2 ESR1 PGR
28 apocrine adenocarcinoma 10.2 ESR1 PGR
29 gender identity disorder 10.2 ESR1 PGR
30 deep angioma 10.2 ESR1 PGR
31 synchronous bilateral breast carcinoma 10.2 ESR1 PGR
32 female reproductive endometrioid cancer 10.2 ESR1 PGR
33 cervical carcinosarcoma 10.2 ESR1 PGR
34 estrogen excess 10.2 ESR1 PGR
35 intramuscular hemangioma 10.2 ESR1 PGR
36 glycogen-rich clear cell breast carcinoma 10.2 ESR1 PGR
37 mammographic density 10.2 ESR1 PGR
38 cervical clear cell adenocarcinoma 10.2 ESR1 PGR
39 peritoneal benign neoplasm 10.2 ESR1 MED12 PGR
40 diffuse peritoneal leiomyomatosis 10.2 ESR1 MED12 PGR
41 breast benign neoplasm 10.2 ESR1 MED12 PGR
42 thoracic benign neoplasm 10.2 ESR1 MED12 PGR
43 retinitis pigmentosa 47 10.2 ESR1 PGR
44 smooth muscle tumor 10.2 ESR1 HMGA2 PGR
45 adenomyosis 10.2 ESR1 GNRH1 PGR
46 inflammatory breast carcinoma 10.2 ESR1 PGR
47 retinitis pigmentosa 20 10.2 ESR1 PGR
48 endometriosis 10.2 ESR1 GNRH1 PGR
49 adenosarcoma 10.1 ESR1 PGR
50 leiomyosarcoma 10.1 FH MED12 PGR

Graphical network of the top 20 diseases related to Uterine Benign Neoplasm:



Diseases related to Uterine Benign Neoplasm

Symptoms & Phenotypes for Uterine Benign Neoplasm

MGI Mouse Phenotypes related to Uterine Benign Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.73 CD3E ESR1 FH HPSE2 MED12 PGR
2 renal/urinary system MP:0005367 9.1 ESR1 FH GNRH1 HPSE2 TLR9 TSC2

Drugs & Therapeutics for Uterine Benign Neoplasm

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 High-intensity Focused Ultrasound in Treatment of Uterine Fibroid Completed NCT02954744 Not Applicable

Search NIH Clinical Center for Uterine Benign Neoplasm

Genetic Tests for Uterine Benign Neoplasm

Anatomical Context for Uterine Benign Neoplasm

MalaCards organs/tissues related to Uterine Benign Neoplasm:

41
Uterus, Lung, Heart, Ovary, Prostate, Cervix, Smooth Muscle

The Foundational Model of Anatomy Ontology organs/tissues related to Uterine Benign Neoplasm:

19
The Uterus

Publications for Uterine Benign Neoplasm

Variations for Uterine Benign Neoplasm

Expression for Uterine Benign Neoplasm

Search GEO for disease gene expression data for Uterine Benign Neoplasm.

Pathways for Uterine Benign Neoplasm

Pathways related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.08 CD3E GNRH1 TGFB3 TLR9
2
Show member pathways
11.25 CD3E TGFB3 TLR9
3 10.86 ESR1 MED12 TSC2

GO Terms for Uterine Benign Neoplasm

Biological processes related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.63 ESR1 HMGA2 MED12 PGR TGFB3 TLR9
2 positive regulation of gene expression GO:0010628 9.62 CD3E HMGA2 TLR9 TNRC6B
3 intracellular steroid hormone receptor signaling pathway GO:0030518 9.26 ESR1 MED12
4 negative regulation of gene expression GO:0010629 9.26 CD3E ESR1 PGR TNRC6B
5 embryonic neurocranium morphogenesis GO:0048702 8.62 MED12 TGFB3

Sources for Uterine Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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