Uterine Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Uterine Benign Neoplasm

MalaCards integrated aliases for Uterine Benign Neoplasm:

Name: Uterine Benign Neoplasm ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060095

Sources

Summaries for Uterine Benign Neoplasm

Disease Ontology : ¹² A female reproductive organ benign neoplasm that is located in the uterus.

MalaCards based summary : Uterine Benign Neoplasm is related to leiomyoma, uterine and uterine corpus adenomatoid tumor. An important gene associated with Uterine Benign Neoplasm is HPSE2 (Heparanase 2 (Inactive)), and among its related pathways/superpathways are NF-KappaB Family Pathway and Th1 Differentiation Pathway. Affiliated tissues include uterus, lung and heart, and related phenotypes are mortality/aging and renal/urinary system

Sources

Related Diseases for Uterine Benign Neoplasm

Diseases related to Uterine Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)

#	Related Disease	Score	Top Affiliating Genes
1	leiomyoma, uterine	31.6	ESR1 FH HMGA2 PGR RAD51B
2	uterine corpus adenomatoid tumor	11.2
3	endometrial stromal nodule	11.2
4	uterine corpus bizarre leiomyoma	11.2
5	uterine corpus adenofibroma	11.2
6	uterine corpus leiomyomatosis	11.2
7	bizarre leiomyoma	10.3	MED12 PGR
8	vestibular gland benign neoplasm	10.3	ESR1 PGR
9	bartholin's gland adenoma	10.3	ESR1 PGR
10	pleomorphic lipoma	10.3	HMGA2 PGR
11	vulvar syringoma	10.3	ESR1 PGR
12	glassy cell carcinoma of the cervix	10.3	ESR1 PGR
13	lung leiomyoma	10.3	ESR1 PGR
14	vulvar benign neoplasm	10.3	ESR1 PGR
15	trigonitis	10.3	ESR1 PGR
16	vulvar leiomyoma	10.3	ESR1 PGR
17	breast medullary carcinoma	10.3	ESR1 PGR
18	breast scirrhous carcinoma	10.3	ESR1 PGR
19	bartholin's gland benign neoplasm	10.3	ESR1 PGR
20	oncocytic breast carcinoma	10.3	ESR1 PGR
21	progesterone-receptor positive breast cancer	10.3	ESR1 PGR
22	progesterone resistance	10.2	ESR1 PGR
23	endometrial squamous cell carcinoma	10.2	ESR1 PGR
24	cribriform carcinoma	10.2	ESR1 PGR
25	endometrial mucinous adenocarcinoma	10.2	ESR1 PGR
26	adenoid basal cell carcinoma	10.2	ESR1 PGR
27	breast adenoid cystic carcinoma	10.2	ESR1 PGR
28	apocrine adenocarcinoma	10.2	ESR1 PGR
29	gender identity disorder	10.2	ESR1 PGR
30	deep angioma	10.2	ESR1 PGR
31	synchronous bilateral breast carcinoma	10.2	ESR1 PGR
32	female reproductive endometrioid cancer	10.2	ESR1 PGR
33	cervical carcinosarcoma	10.2	ESR1 PGR
34	estrogen excess	10.2	ESR1 PGR
35	intramuscular hemangioma	10.2	ESR1 PGR
36	glycogen-rich clear cell breast carcinoma	10.2	ESR1 PGR
37	mammographic density	10.2	ESR1 PGR
38	cervical clear cell adenocarcinoma	10.2	ESR1 PGR
39	peritoneal benign neoplasm	10.2	ESR1 MED12 PGR
40	diffuse peritoneal leiomyomatosis	10.2	ESR1 MED12 PGR
41	breast benign neoplasm	10.2	ESR1 MED12 PGR
42	thoracic benign neoplasm	10.2	ESR1 MED12 PGR
43	retinitis pigmentosa 47	10.2	ESR1 PGR
44	smooth muscle tumor	10.2	ESR1 HMGA2 PGR
45	adenomyosis	10.2	ESR1 GNRH1 PGR
46	inflammatory breast carcinoma	10.2	ESR1 PGR
47	retinitis pigmentosa 20	10.2	ESR1 PGR
48	endometriosis	10.2	ESR1 GNRH1 PGR
49	adenosarcoma	10.1	ESR1 PGR
50	leiomyosarcoma	10.1	FH MED12 PGR

Graphical network of the top 20 diseases related to Uterine Benign Neoplasm:

Sources

Symptoms & Phenotypes for Uterine Benign Neoplasm

MGI Mouse Phenotypes related to Uterine Benign Neoplasm:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	mortality/aging	MP:0010768	9.73	CD3E ESR1 FH HPSE2 MED12 PGR
2	renal/urinary system	MP:0005367	9.1	ESR1 FH GNRH1 HPSE2 TLR9 TSC2

Sources

Drugs & Therapeutics for Uterine Benign Neoplasm

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	High-intensity Focused Ultrasound in Treatment of Uterine Fibroid	Completed	NCT02954744	Not Applicable

Search NIH Clinical Center for Uterine Benign Neoplasm

Sources

Genetic Tests for Uterine Benign Neoplasm

Sources

Anatomical Context for Uterine Benign Neoplasm

MalaCards organs/tissues related to Uterine Benign Neoplasm:

⁴¹

Uterus, Lung, Heart, Ovary, Prostate, Cervix, Smooth Muscle

The Foundational Model of Anatomy Ontology organs/tissues related to Uterine Benign Neoplasm:

¹⁹

The Uterus

Sources

Publications for Uterine Benign Neoplasm

Sources

Genes for Uterine Benign Neoplasm

Genes related to Uterine Benign Neoplasm (0 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	HPSE2	Heparanase 2 (Inactive)	Protein Coding	18.44	DISEASES inferred ¹⁵
2	PGR	Progesterone Receptor	Protein Coding	17.15	DISEASES inferred ¹⁵
3	MED12	Mediator Complex Subunit 12	Protein Coding	17.1	DISEASES inferred ¹⁵
4	TLR9	Toll Like Receptor 9	Protein Coding	16.44	DISEASES inferred ¹⁵ ¹⁵
5	HMGA2	High Mobility Group AT-Hook 2	Protein Coding	16.31	DISEASES inferred ¹⁵
6	GNRH1	Gonadotropin Releasing Hormone 1	Protein Coding	16.29	DISEASES inferred ¹⁵
7	ESR1	Estrogen Receptor 1	Protein Coding	15.88	DISEASES inferred ¹⁵
8	CD3E	CD3e Molecule	Protein Coding	15.73	DISEASES inferred ¹⁵
9	RAD51B	RAD51 Paralog B	Protein Coding	15.65	DISEASES inferred ¹⁵
10	PRDM10	PR/SET Domain 10	Protein Coding	15.64	DISEASES inferred ¹⁵
11	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	15.63	DISEASES inferred ¹⁵
12	FH	Fumarate Hydratase	Protein Coding	15.63	DISEASES inferred ¹⁵
13	TNRC6B	Trinucleotide Repeat Containing 6B	Protein Coding	15.44	DISEASES inferred ¹⁵
14	TSC2	TSC Complex Subunit 2	Protein Coding	15.24	DISEASES inferred ¹⁵
15	IVL	Involucrin	Protein Coding	6.68	DISEASES inferred ¹⁵
16	BET1L	Bet1 Golgi Vesicular Membrane Trafficking Protein Like	Protein Coding	5.77	DISEASES inferred ¹⁵
17	FAM241B	Family With Sequence Similarity 241 Member B	Protein Coding	5.36	DISEASES inferred ¹⁵

Sources

Variations for Uterine Benign Neoplasm

Sources

Expression for Uterine Benign Neoplasm

Search GEO for disease gene expression data for Uterine Benign Neoplasm.

Sources

Pathways for Uterine Benign Neoplasm

Pathways related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.08	CD3E GNRH1 TGFB3 TLR9
2	Th1 Differentiation Pathway ⁶⁵ Show member pathways IL27-mediated signaling events ¹ Th17 Differentiation Pathway ⁶⁵	11.25	CD3E TGFB3 TLR9
3	Thyroid hormone signaling pathway ³⁷	10.86	ESR1 MED12 TSC2

Sources

GO Terms for Uterine Benign Neoplasm

Biological processes related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	9.63	ESR1 HMGA2 MED12 PGR TGFB3 TLR9
2	positive regulation of gene expression	GO:0010628	9.62	CD3E HMGA2 TLR9 TNRC6B
3	intracellular steroid hormone receptor signaling pathway	GO:0030518	9.26	ESR1 MED12
4	negative regulation of gene expression	GO:0010629	9.26	CD3E ESR1 PGR TNRC6B
5	embryonic neurocranium morphogenesis	GO:0048702	8.62	MED12 TGFB3

Sources

Sources for Uterine Benign Neoplasm

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia