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MCID: UTR031
MIFTS: 29

Uterine Benign Neoplasm

Categories: Cancer diseases, Reproductive diseases
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Genes Tissues Related diseases
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Aliases & Classifications for Uterine Benign Neoplasm

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MalaCards integrated aliases for Uterine Benign Neoplasm:

Name: Uterine Benign Neoplasm 11 14

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 11 DOID:0060095
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Summaries for Uterine Benign Neoplasm

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Disease Ontology: 11 A female reproductive organ benign neoplasm that is located in the uterus.

MalaCards based summary: Uterine Benign Neoplasm is related to endometrial stromal nodule and leiomyoma, uterine. An important gene associated with Uterine Benign Neoplasm is PGR (Progesterone Receptor), and among its related pathways/superpathways are Signal Transduction and Signaling by Receptor Tyrosine Kinases. Affiliated tissues include uterus, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and homeostasis/metabolism
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Related Diseases for Uterine Benign Neoplasm

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Diseases related to Uterine Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 364)
# Related Disease Score Top Affiliating Genes
1 endometrial stromal nodule 32.3 MME JAZF1 CALD1
2 leiomyoma, uterine 32.1 PGR HMGA2 GNRH1 FH ESR2 ESR1
3 endometrial hyperplasia 32.0 TP53 PTEN PGR HOXA10 ESR2 ESR1
4 uterine corpus adenomatoid tumor 11.1
5 uterine corpus bizarre leiomyoma 11.1
6 adenomyoma of uterine corpus 11.1
7 uterine corpus adenofibroma 11.1
8 uterine ligament papillary cystadenoma associated with von hippel-lindau disease 11.1
9 uterine corpus leiomyomatosis 11.1
10 uterine corpus cellular leiomyoma 11.1
11 nipple carcinoma 10.5 PGR ESR1
12 breast mucinous cystadenocarcinoma 10.5 PGR ESR1
13 breast fibroadenosis 10.5 PGR ESR1
14 rectum carcinoma in situ 10.5 ESR2 ESR1
15 breast duct papilloma 10.5 PTEN PGR
16 bulbospinal polio 10.5 PGR ESR1
17 spinal polio 10.5 PGR ESR1
18 glycogen-rich clear cell breast carcinoma 10.5 PGR ESR1
19 adult cystic nephroma 10.5 PGR ESR1
20 breast cystic hypersecretory carcinoma 10.5 PGR ESR1
21 adenosquamous breast carcinoma 10.5 TP53 PGR
22 nonmucinous bronchioloalveolar adenocarcinoma 10.5 ESR2 ESR1
23 high-grade astrocytoma 10.5 TP53 PTEN
24 cervical adenomyoma 10.5 PGR MME
25 cervical benign neoplasm 10.5 PGR MME
26 cystadenofibroma 10.5 TP53 MME
27 basaloid lung carcinoma 10.5 TP53 PGR
28 cervical adenocarcinoma 10.5 TP53 PGR ESR1
29 polyp of corpus uteri 10.5 PGR GNRH1 ESR1
30 uterus leiomyosarcoma 10.5 PGR HMGA2 FH
31 bartholin's gland adenoma 10.5 TP53 PGR ESR1
32 bartholin's gland benign neoplasm 10.5 TP53 PGR ESR1
33 vestibular gland benign neoplasm 10.5 TP53 PGR ESR1
34 pulmonary vein leiomyosarcoma 10.5 PGR CALD1
35 progesterone resistance 10.5 PGR ESR2 ESR1
36 vagina leiomyoma 10.5 PGR CALD1
37 oncocytic breast carcinoma 10.5 PGR ESR1
38 bartholin's duct cyst 10.5 GNRH1 CALD1
39 progesterone-receptor positive breast cancer 10.5 PGR ESR1 CYP19A1
40 breast squamous cell carcinoma 10.5 PGR ESR1
41 vagina leiomyosarcoma 10.5 PGR ESR1 CALD1
42 vulvar benign neoplasm 10.5 PGR ESR1 CALD1
43 comedo carcinoma 10.5 TP53 PGR ESR1
44 lung leiomyoma 10.5 PGR CALD1
45 apocrine adenocarcinoma 10.5 TP53 PGR ESR1
46 vaginal endometrial stromal tumor 10.5 MME CALD1
47 colon leiomyoma 10.5 MED12 HMGA2 FH
48 ovarian serous cystadenofibroma 10.5 TP53 PGR AMH
49 fibroma 10.5 PGR ESR1 CTNNB1
50 ovarian serous adenofibroma 10.5 TP53 PGR AMH

Graphical network of the top 20 diseases related to Uterine Benign Neoplasm:



Diseases related to Uterine Benign Neoplasm
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Symptoms & Phenotypes for Uterine Benign Neoplasm

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GenomeRNAi Phenotypes related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.19 AKT1 AMH CALD1 CTNNB1 CYP19A1 EPPIN
2 no effect GR00402-S-2 10.19 AKT1 AMH CALD1 CTNNB1 CYP19A1 EPPIN
3 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.26 ESR1 ESR2 FH PTEN

MGI Mouse Phenotypes related to Uterine Benign Neoplasm:

45 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.42 AKT1 AMH CTNNB1 CYP19A1 EPPIN ESR1
2 nervous system MP:0003631 10.41 AKT1 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1
3 growth/size/body region MP:0005378 10.41 AKT1 AMH CALD1 CTNNB1 CYP19A1 EPPIN
4 renal/urinary system MP:0005367 10.37 CALD1 CTNNB1 CYP19A1 EPPIN ESR1 ESR2
5 endocrine/exocrine gland MP:0005379 10.36 AKT1 AMH CTNNB1 CYP19A1 EPPIN ESR1
6 neoplasm MP:0002006 10.32 AKT1 AMH CTNNB1 ESR1 ESR2 GNRH1
7 normal MP:0002873 10.32 AKT1 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1
8 cellular MP:0005384 10.28 AKT1 CTNNB1 CYP19A1 ESR1 ESR2 FH
9 muscle MP:0005369 10.25 AKT1 CALD1 CTNNB1 CYP19A1 ESR1 ESR2
10 limbs/digits/tail MP:0005371 10.22 CTNNB1 ESR1 ESR2 HMGA2 HOXA10 IGF1
11 liver/biliary system MP:0005370 10.19 AKT1 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1
12 cardiovascular system MP:0005385 10.18 AKT1 CTNNB1 CYP19A1 EPPIN ESR1 ESR2
13 digestive/alimentary MP:0005381 10.17 CTNNB1 CYP19A1 EPPIN ESR1 ESR2 GNRH1
14 adipose tissue MP:0005375 10.16 AKT1 CYP19A1 ESR1 ESR2 HMGA2 IGF1
15 reproductive system MP:0005389 10.16 AKT1 AMH CTNNB1 CYP19A1 EPPIN ESR1
16 immune system MP:0005387 10.1 AKT1 CTNNB1 CYP19A1 EPPIN ESR1 ESR2
17 skeleton MP:0005390 9.97 AKT1 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1
18 mortality/aging MP:0010768 9.83 AKT1 CALD1 CTNNB1 EPPIN ESR1 ESR2
19 integument MP:0010771 9.47 AKT1 CTNNB1 CYP19A1 EPPIN ESR1 ESR2
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Drugs & Therapeutics for Uterine Benign Neoplasm

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Search Clinical Trials, NIH Clinical Center for Uterine Benign Neoplasm

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Genetic Tests for Uterine Benign Neoplasm

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Anatomical Context for Uterine Benign Neoplasm

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Organs/tissues related to Uterine Benign Neoplasm:

FMA: Uterus
MalaCards : Uterus
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Publications for Uterine Benign Neoplasm

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Variations for Uterine Benign Neoplasm

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Expression for Uterine Benign Neoplasm

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Search GEO for disease gene expression data for Uterine Benign Neoplasm.
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Pathways for Uterine Benign Neoplasm

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Pathways related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Signal Transduction 66
13.59 AKT1 AMH CTNNB1 ESR1 ESR2 GNRH1
2
Signaling by Receptor Tyrosine Kinases 66
12.76 PGR IGF1 ESR1 CTNNB1 AKT1
3
Endometrial cancer 74
Show member pathways
 12.6 TP53 PTEN IGF1 CTNNB1 AKT1
4
Malignant pleural mesothelioma 74
12.58 TP53 PTEN IGF1 CTNNB1 AKT1
5
Hepatocyte growth factor receptor signaling 74
Show member pathways
 12.31 TP53 PTEN ESR1 CTNNB1 AKT1
6
Development Ligand-independent activation of ESR1 and ESR2 22
Show member pathways
 12.24 AKT1 ESR1 ESR2 IGF1
7
Focal adhesion 74
12.19 PTEN IGF1 CTNNB1 AKT1
8
Development IGF-1 receptor signaling 22
Show member pathways
 12.15 TP53 PTEN IGF1 AKT1
9
Transcription Androgen Receptor nuclear signaling 22
Show member pathways
 12.01 AKT1 CTNNB1 IGF1 PTEN
10
TGF-beta Signaling Pathways 65
11.82 ESR2 ESR1 AKT1
11
Small cell lung cancer 74
11.82 TP53 PTEN AKT1
12
TP53 Regulates Metabolic Genes 66
11.77 TP53 PTEN AKT1
13
16p11.2 proximal deletion syndrome 74
11.68 TP53 PTEN ESR1
14
MECP2 and associated Rett syndrome 74
11.67 PTEN IGF1 AKT1
15
Primary focal segmental glomerulosclerosis (FSGS) 74
11.66 MME CTNNB1 AKT1
16
Breast cancer pathway 74
Show member pathways
 11.66 TP53 PTEN PGR IGF1 ESR2 ESR1
17
Validated nuclear estrogen receptor alpha network 61
11.61 PGR ESR2 ESR1
18
Integrated breast cancer pathway 74
11.61 TP53 PTEN ESR1 CYP19A1 CTNNB1 AKT1
19
Pathways affected in adenoid cystic carcinoma 74
11.58 TP53 PTEN AKT1
20
Head and neck squamous cell carcinoma 74
11.57 TP53 PTEN CTNNB1 AKT1
21
Prader-Willi and Angelman syndrome 74
11.56 TP53 OXT GNRH1
22
Copper homeostasis 74
Show member pathways
 11.53 TP53 PTEN AKT1
23
AP-1 transcription factor network 61
11.51 TP53 PTEN ESR1 CTNNB1
24
IL-18 signaling pathway 74
11.43 TP53 PTEN CTNNB1
25
Ovarian tumor domain proteases 66
11.3 TP53 PTEN ESR1
26
Integrated cancer pathway 74
11.28 TP53 PTEN AKT1
27
Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling 74
11.24 PTEN IGF1 AKT1
28
Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4) 74
11.18 PGR ESR2 ESR1
29
Ovarian infertility 74
11.11 PGR ESR2 CYP19A1 AKT1
30
Plasma membrane estrogen receptor signaling 61
11.01 ESR2 ESR1 AKT1
31
Mammary gland development pathway - Puberty (Stage 2 of 4) 74
10.77 PGR ESR1
32
TCA cycle in senescence 74
10.64 TP53 FH
33
Caloric restriction and aging 74
10.45 TP53 IGF1 AKT1
34
Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics 60
9.93 ESR2 ESR1 CYP19A1
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GO Terms for Uterine Benign Neoplasm

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Biological processes related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.41 TP53 PGR MED12 IGF1 HOXA10 HMGA2
2 negative regulation of apoptotic process GO:0043066 10.35 TP53 PTEN IGF1 HMGA2 CTNNB1 AKT1
3 positive regulation of DNA-templated transcription GO:0045893 10.27 TP53 MED12 IGF1 HMGA2 ESR2 ESR1
4 positive regulation of gene expression GO:0010628 10.17 AKT1 AMH CTNNB1 HMGA2 IGF1 PGR
5 heart development GO:0007507 10.1 TP53 PTEN OXT MED12 CTNNB1
6 epithelial to mesenchymal transition GO:0001837 10.03 IGF1 HMGA2 CTNNB1
7 phosphatidylinositol 3-kinase signaling GO:0014065 10.02 PTEN IGF1 AKT1
8 response to estradiol GO:0032355 10.01 OXT ESR1 CYP19A1 CTNNB1
9 cell population proliferation GO:0008283 9.98 AKT1 CTNNB1 IGF1 PTEN TP53
10 negative regulation of gene expression GO:0010629 9.9 TP53 PGR IGF1 ESR1 CTNNB1 AKT1
11 male mating behavior GO:0060179 9.84 PTEN OXT
12 positive regulation of RNA polymerase II transcription preinitiation complex assembly GO:0045899 9.83 TP53 ESR1
13 embryonic organ development GO:0048568 9.81 CTNNB1 MED12 TP53
14 uterus development GO:0060065 9.73 HOXA10 ESR1 CYP19A1
15 cellular response to decreased oxygen levels GO:0036294 9.65 PTEN AKT1
16 positive regulation of DNA-binding transcription factor activity GO:0051091 9.65 PTEN ESR2 ESR1 CTNNB1 AKT1
17 intracellular steroid hormone receptor signaling pathway GO:0030518 9.1 PGR ESR2 ESR1

Molecular functions related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.87 OXT IGF1 GNRH1 AMH
2 steroid binding GO:0005496 9.73 PGR ESR2 ESR1
3 estrogen response element binding GO:0034056 9.67 ESR2 ESR1
4 enzyme binding GO:0019899 9.47 TP53 PTEN PGR ESR2 ESR1 CTNNB1
5 nuclear estrogen receptor activity GO:0030284 9.46 ESR2 ESR1
6 nuclear steroid receptor activity GO:0003707 9.35 PGR ESR2 ESR1
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Sources for Uterine Benign Neoplasm

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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