MCID: UTR031
MIFTS: 20

Uterine Benign Neoplasm

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Uterine Benign Neoplasm

MalaCards integrated aliases for Uterine Benign Neoplasm:

Name: Uterine Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060095

Summaries for Uterine Benign Neoplasm

MalaCards based summary : Uterine Benign Neoplasm is related to leiomyoma, uterine and bizarre leiomyoma. An important gene associated with Uterine Benign Neoplasm is HPSE2 (Heparanase 2 (Inactive)), and among its related pathways/superpathways is Thyroid hormone signaling pathway. Related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and growth/size/body region

Related Diseases for Uterine Benign Neoplasm

Diseases related to Uterine Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 leiomyoma, uterine 11.1
2 bizarre leiomyoma 10.9 MED12 PGR
3 vulvar syringoma 10.9 ESR1 PGR
4 lung leiomyoma 10.9 ESR1 PGR
5 vestibular gland benign neoplasm 10.8 ESR1 PGR
6 bartholin's gland adenoma 10.8 ESR1 PGR
7 glassy cell carcinoma of the cervix 10.8 ESR1 PGR
8 vulvar benign neoplasm 10.8 ESR1 PGR
9 trigonitis 10.8 ESR1 PGR
10 vulvar leiomyoma 10.8 ESR1 PGR
11 breast medullary carcinoma 10.8 ESR1 PGR
12 breast scirrhous carcinoma 10.8 ESR1 PGR
13 progesterone resistance 10.8 ESR1 PGR
14 progesterone-receptor positive breast cancer 10.8 ESR1 PGR
15 cribriform carcinoma 10.8 ESR1 PGR
16 oncocytic breast carcinoma 10.8 ESR1 PGR
17 endometrial squamous cell carcinoma 10.8 ESR1 PGR
18 gastric signet ring cell adenocarcinoma 10.8 ESR1 PGR
19 endometrial mucinous adenocarcinoma 10.8 ESR1 PGR
20 adenoid basal cell carcinoma 10.8 ESR1 PGR
21 apocrine adenocarcinoma 10.8 ESR1 PGR
22 gender identity disorder 10.8 ESR1 PGR
23 bartholin's gland benign neoplasm 10.8 ESR1 PGR
24 deep angioma 10.7 ESR1 PGR
25 synchronous bilateral breast carcinoma 10.7 ESR1 PGR
26 breast adenoid cystic carcinoma 10.7 ESR1 PGR
27 cervical carcinosarcoma 10.7 ESR1 PGR
28 estrogen excess 10.7 ESR1 PGR
29 intramuscular hemangioma 10.7 ESR1 PGR
30 glycogen-rich clear cell breast carcinoma 10.7 ESR1 PGR
31 mammographic density 10.7 ESR1 PGR
32 retinitis pigmentosa 47 10.7 ESR1 PGR
33 uterine corpus cancer 10.6 ESR1 PGR
34 adenomyosis 10.6 ESR1 PGR
35 retinitis pigmentosa 20 10.6 ESR1 PGR
36 luminal breast carcinoma 10.6 ESR1 PGR
37 breast benign neoplasm 10.6 ESR1 MED12 PGR
38 thoracic benign neoplasm 10.6 ESR1 MED12 PGR
39 adenosarcoma 10.6 ESR1 PGR
40 smooth muscle tumor 10.6 ESR1 HMGA2 PGR
41 cervical clear cell adenocarcinoma 10.6 ESR1 PGR
42 leiomyosarcoma 10.5 FH MED12 PGR
43 hereditary renal cell carcinoma 10.5 FH TSC2
44 perivascular epithelioid cell tumor 10.5 PGR TSC2
45 endometriosis of ovary 10.5 ESR1 PGR
46 multilocular clear cell renal cell carcinoma 10.5 TGFB3 TSC2
47 inflammatory breast carcinoma 10.5 ESR1 PGR
48 juvenile nasopharyngeal angiofibroma 10.4 ESR1 PGR TGFB3
49 mixed cell type cancer 10.4 ESR1 PGR
50 breast papillary carcinoma 10.4 ESR1 PGR TSC2

Graphical network of the top 20 diseases related to Uterine Benign Neoplasm:



Diseases related to Uterine Benign Neoplasm

Symptoms & Phenotypes for Uterine Benign Neoplasm

GenomeRNAi Phenotypes related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 8.8 ESR1 FH RAD51B

MGI Mouse Phenotypes related to Uterine Benign Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.65 RGS7 TGFB3 TNRC6B TSC2 VCAN CCDC57
2 mortality/aging MP:0010768 9.4 RAD51B RGS7 TGFB3 TNRC6B TSC2 VCAN

Drugs & Therapeutics for Uterine Benign Neoplasm

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 High-intensity Focused Ultrasound in Treatment of Uterine Fibroid Completed NCT02954744 Not Applicable

Search NIH Clinical Center for Uterine Benign Neoplasm

Genetic Tests for Uterine Benign Neoplasm

Anatomical Context for Uterine Benign Neoplasm

Publications for Uterine Benign Neoplasm

Variations for Uterine Benign Neoplasm

Expression for Uterine Benign Neoplasm

Search GEO for disease gene expression data for Uterine Benign Neoplasm.

Pathways for Uterine Benign Neoplasm

Pathways related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.86 ESR1 MED12 TSC2

GO Terms for Uterine Benign Neoplasm

Biological processes related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription initiation from RNA polymerase II promoter GO:0006367 9.43 ESR1 MED12 PGR
2 stem cell differentiation GO:0048863 9.16 ESR1 HMGA2
3 intracellular steroid hormone receptor signaling pathway GO:0030518 8.96 ESR1 MED12
4 embryonic neurocranium morphogenesis GO:0048702 8.62 MED12 TGFB3

Sources for Uterine Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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