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MCID: UTR031
MIFTS: 29

Uterine Benign Neoplasm

Categories: Cancer diseases, Reproductive diseases
Genes Tissues Related diseases Pathways
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Aliases & Classifications for Uterine Benign Neoplasm

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MalaCards integrated aliases for Uterine Benign Neoplasm:

Name: Uterine Benign Neoplasm 12 15

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0060095
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Summaries for Uterine Benign Neoplasm

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Disease Ontology : 12 A female reproductive organ benign neoplasm that is located in the uterus.

MalaCards based summary : Uterine Benign Neoplasm is related to endometrial stromal nodule and endometrial hyperplasia. An important gene associated with Uterine Benign Neoplasm is HPSE2 (Heparanase 2 (Inactive)), and among its related pathways/superpathways are Pathways in cancer and Gastric cancer. Affiliated tissues include uterus, and related phenotypes are Decreased TP53 mRNA expression and Decreased TP53 mRNA expression

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Related Diseases for Uterine Benign Neoplasm

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Diseases related to Uterine Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 289)
# Related Disease Score Top Affiliating Genes
1 endometrial stromal nodule 32.7 MME CALD1
2 endometrial hyperplasia 32.3 TP53 PTEN PGR HOXA10 ESR2 ESR1
3 leiomyoma, uterine 32.0 PGR MED12 IGF1 HPSE2 HMGA2 GNRH1
4 uterine corpus adenomatoid tumor 11.3
5 uterine corpus bizarre leiomyoma 11.3
6 adenomyoma of uterine corpus 11.3
7 uterine corpus adenofibroma 11.3
8 uterine ligament papillary cystadenoma associated with von hippel-lindau disease 11.3
9 uterine corpus leiomyomatosis 11.3
10 uterine corpus cellular leiomyoma 11.3
11 glassy cell carcinoma of the cervix 10.7 PGR ESR1
12 bartholin's gland adenoid cystic carcinoma 10.7 PGR ESR1
13 chronic tympanitis 10.7 PGR ESR1
14 infertility due to extratesticular cause 10.7 GNRH1 ESR1
15 granulomatous endometritis 10.7 PGR ESR1
16 breast duct papilloma 10.7 PTEN PGR
17 vaginal glandular tumor 10.7 PGR ESR1
18 cervical adenomyoma 10.7 PGR MME
19 vulvar syringoma 10.7 PGR ESR1
20 trigonitis 10.7 PGR ESR1
21 liver adenomatosis 10.7 PGR CTNNB1
22 fat necrosis of breast 10.7 HMGA2 ESR1
23 fallopian tube endometriosis 10.7 PGR MME
24 cervical benign neoplasm 10.7 PGR MME
25 breast scirrhous carcinoma 10.7 PGR ESR1
26 nonmucinous bronchioloalveolar adenocarcinoma 10.7 ESR2 ESR1
27 vaginitis 10.7 ESR2 ESR1 EPPIN
28 oncocytic breast carcinoma 10.7 PGR ESR1
29 endometrial squamous cell carcinoma 10.7 TP53 PGR
30 cervical clear cell adenocarcinoma 10.7 PGR ESR1
31 bartholin's gland adenoma 10.7 TP53 PGR ESR1
32 bartholin's gland benign neoplasm 10.7 TP53 PGR ESR1
33 vestibular gland benign neoplasm 10.7 TP53 PGR ESR1
34 pulmonary vein leiomyosarcoma 10.7 PGR CALD1
35 cystadenocarcinoma 10.7 TP53 PGR ESR2
36 ovarian seromucinous carcinoma 10.7 TP53 PGR ESR1
37 adult type testicular granulosa cell tumor 10.7 PGR ESR1
38 cecum lymphoma 10.7 TP53 MME
39 comedo carcinoma 10.7 TP53 PGR ESR1
40 cervical serous adenocarcinoma 10.7 PGR MME
41 progesterone resistance 10.7 PGR ESR2 ESR1
42 vulvar benign neoplasm 10.7 PGR CALD1
43 atrophy of prostate 10.6 TP53 GNRH1 EPPIN
44 lung leiomyoma 10.6 PGR ESR1 CALD1
45 apocrine adenocarcinoma 10.6 TP53 PGR ESR1
46 breast leiomyoma 10.6 PGR MME FH
47 juvenile nasopharyngeal angiofibroma 10.6 PGR ESR1 CYP19A1
48 uterine corpus adenosarcoma 10.6 PGR MME ESR1
49 mixed endometrial stromal and smooth muscle tumor 10.6 MME CALD1
50 vaginal endometrial stromal tumor 10.6 MME CALD1

Graphical network of the top 20 diseases related to Uterine Benign Neoplasm:



Diseases related to Uterine Benign Neoplasm
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Symptoms & Phenotypes for Uterine Benign Neoplasm

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GenomeRNAi Phenotypes related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased TP53 mRNA expression GR00389-S-5 9.26 TP53
2 Decreased TP53 mRNA expression GR00389-S-6 9.26 ESR2 HMGA2 TP53
3 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 8.92 ESR1 ESR2 FH PTEN

MGI Mouse Phenotypes related to Uterine Benign Neoplasm:

45 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.34 AMH CTNNB1 CYP19A1 ESR1 ESR2 FH
2 cellular MP:0005384 10.33 CTNNB1 CYP19A1 ESR1 ESR2 FH IGF1
3 cardiovascular system MP:0005385 10.3 CTNNB1 CYP19A1 ESR1 ESR2 HOXA10 IGF1
4 endocrine/exocrine gland MP:0005379 10.3 AMH CTNNB1 CYP19A1 ESR1 ESR2 GNRH1
5 growth/size/body region MP:0005378 10.29 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1 HOXA10
6 integument MP:0010771 10.22 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1 IGF1
7 digestive/alimentary MP:0005381 10.19 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1 HOXA10
8 adipose tissue MP:0005375 10.11 CYP19A1 ESR1 ESR2 HOXA10 IGF1 PTEN
9 limbs/digits/tail MP:0005371 10.11 CTNNB1 ESR1 ESR2 HOXA10 IGF1 MED12
10 nervous system MP:0003631 10.1 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1 HOXA10
11 liver/biliary system MP:0005370 10.09 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1 MME
12 neoplasm MP:0002006 10.07 AMH CTNNB1 ESR1 ESR2 GNRH1 IGF1
13 muscle MP:0005369 10.01 CTNNB1 CYP19A1 ESR1 ESR2 IGF1 PGR
14 normal MP:0002873 10 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1 IGF1
15 renal/urinary system MP:0005367 9.9 CTNNB1 CYP19A1 ESR1 ESR2 FH GNRH1
16 reproductive system MP:0005389 9.73 AMH CTNNB1 CYP19A1 ESR1 ESR2 GNRH1
17 skeleton MP:0005390 9.36 CTNNB1 CYP19A1 ESR1 ESR2 GNRH1 HOXA10
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Drugs & Therapeutics for Uterine Benign Neoplasm

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Therapeutic Efficacy of High-intensity Focused Ultrasound in the Treatment of Uterine Fibroid Completed NCT02954744

Search NIH Clinical Center for Uterine Benign Neoplasm

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Genetic Tests for Uterine Benign Neoplasm

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Anatomical Context for Uterine Benign Neoplasm

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The Foundational Model of Anatomy Ontology organs/tissues related to Uterine Benign Neoplasm:

19
Uterus

MalaCards organs/tissues related to Uterine Benign Neoplasm:

40
Uterus
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Publications for Uterine Benign Neoplasm

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Variations for Uterine Benign Neoplasm

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Expression for Uterine Benign Neoplasm

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Search GEO for disease gene expression data for Uterine Benign Neoplasm.
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Pathways for Uterine Benign Neoplasm

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Pathways related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Pathways in cancer 36
12.64 TP53 PTEN IGF1 FH ESR2 ESR1
2
Gastric cancer 36
Show member pathways
 12.53 TP53 PTEN PGR IGF1 ESR2 ESR1
3
Glioma 36
Show member pathways
 12.48 TSC2 TP53 PTEN IGF1 ESR2 ESR1
4
Development IGF-1 receptor signaling 22
Show member pathways
 12.23 TSC2 TP53 PTEN IGF1
5
DNA Damage Response 1
Show member pathways
 12.21 TSC2 TP53 PTEN IGF1
6
Translation Non-genomic (rapid) action of Androgen Receptor 22
Show member pathways
 12.17 TSC2 TP53 PTEN IGF1 CTNNB1
7
Proteoglycans in cancer 36
12.14 TP53 IGF1 HPSE2 ESR1 CTNNB1
8
Transcriptional misregulation in cancer 36
12.11 TP53 IGF1 HOXA10 HMGA2
9
Thyroid hormone signaling pathway 36
11.74 TSC2 TP53 MED12 ESR1 CTNNB1
10
Nuclear Receptor transcription pathway 65
Show member pathways
 11.7 PGR ESR2 ESR1
11
TP53 Regulates Metabolic Genes 65
11.66 TSC2 TP53 PTEN
12
Glioblastoma Multiforme 63
11.6 TSC2 TP53 PTEN IGF1 CTNNB1
13
LKB1 signaling events 1
11.31 TSC2 TP53 ESR1
14
Integrated Breast Cancer Pathway 1
11.29 TSC2 TP53 PTEN ESR1 CYP19A1 CTNNB1
15
Ovarian tumor domain proteases 65
11.24 TP53 PTEN ESR1
16
Ovarian Infertility Genes 1
11.16 PGR ESR2 CYP19A1
17
Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics 60
9.73 ESR2 ESR1 CYP19A1
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GO Terms for Uterine Benign Neoplasm

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Biological processes related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.01 TP53 PGR MED12 IGF1 HOXA10 HMGA2
2 negative regulation of cell proliferation GO:0008285 9.97 TSC2 TP53 PTEN GNRH1 CTNNB1
3 negative regulation of apoptotic process GO:0043066 9.95 TP53 PTEN IGF1 HMGA2 GNRH1 CTNNB1
4 cell-cell signaling GO:0007267 9.91 PGR GNRH1 ESR2 AMH
5 positive regulation of apoptotic process GO:0043065 9.91 TP53 PTEN MIR146A HMGA2 CTNNB1
6 positive regulation of transcription, DNA-templated GO:0045893 9.87 TP53 MED12 IGF1 HMGA2 ESR2 ESR1
7 aging GO:0007568 9.84 PTEN MME GNRH1 AMH
8 canonical Wnt signaling pathway GO:0060070 9.77 PTEN MED12 CTNNB1
9 heart development GO:0007507 9.77 TSC2 TP53 PTEN MED12 CTNNB1
10 positive regulation of DNA-binding transcription factor activity GO:0051091 9.76 PTEN ESR2 ESR1 CTNNB1
11 response to estradiol GO:0032355 9.73 PTEN ESR1 CYP19A1 CTNNB1
12 negative regulation of protein kinase B signaling GO:0051898 9.72 TSC2 PTEN MIR146A
13 protein kinase B signaling GO:0043491 9.67 TSC2 PTEN IGF1
14 replicative senescence GO:0090399 9.62 TP53 MME
15 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.61 TP53 ESR1
16 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.6 TP53 ESR1
17 positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 9.58 MIR146A CTNNB1
18 prostate gland growth GO:0060736 9.57 PTEN CYP19A1
19 regulation of toll-like receptor signaling pathway GO:0034121 9.56 MIR146A ESR1
20 transcription initiation from RNA polymerase II promoter GO:0006367 9.55 PTEN PGR MED12 ESR2 ESR1
21 negative regulation of mitophagy GO:1901525 9.52 TSC2 TP53
22 uterus development GO:0060065 9.43 HOXA10 ESR1 CYP19A1
23 negative regulation of gene expression GO:0010629 9.43 TP53 PGR MIR146A IGF1 ESR1 CTNNB1
24 positive regulation of gene expression GO:0010628 9.17 TP53 PTEN MIR146A IGF1 HMGA2 CTNNB1

Molecular functions related to Uterine Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.88 TP53 PGR HOXA10 HMGA2 ESR1
2 transcription factor binding GO:0008134 9.83 TP53 MED12 HMGA2 ESR1 CTNNB1
3 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.7 TP53 PGR MED12 HOXA10 HMGA2 ESR2
4 beta-catenin binding GO:0008013 9.67 MED12 ESR1 CTNNB1
5 steroid hormone receptor activity GO:0003707 9.63 PGR ESR2 ESR1
6 nuclear receptor activity GO:0004879 9.54 PGR ESR2 ESR1
7 steroid binding GO:0005496 9.43 PGR ESR2 ESR1
8 enzyme binding GO:0019899 9.43 TP53 PTEN PGR ESR2 ESR1 CTNNB1
9 estrogen receptor activity GO:0030284 9.4 ESR2 ESR1
10 estrogen response element binding GO:0034056 9.32 ESR2 ESR1
11 repressing transcription factor binding GO:0070491 8.92 PGR ESR2 ESR1 CTNNB1
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Sources for Uterine Benign Neoplasm

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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