MCID: UTR032
MIFTS: 31

Uterine Body Mixed Cancer

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Uterine Body Mixed Cancer

MalaCards integrated aliases for Uterine Body Mixed Cancer:

Name: Uterine Body Mixed Cancer 12 15
Malignant Mixed Tumor, Not Otherwise Specified 74
Malignant Mixed Tumor of Corpus Uteri 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4114
NCIt 51 C6311

Summaries for Uterine Body Mixed Cancer

Disease Ontology : 12 A uterine corpus cancer that has material basis in more than one type of cell.

MalaCards based summary : Uterine Body Mixed Cancer, also known as malignant mixed tumor, not otherwise specified, is related to uterine carcinosarcoma and uterine corpus adenocarcinofibroma. An important gene associated with Uterine Body Mixed Cancer is PPP2R1A (Protein Phosphatase 2 Scaffold Subunit Aalpha), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Circadian entrainment. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Uterine Body Mixed Cancer

Diseases related to Uterine Body Mixed Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
# Related Disease Score Top Affiliating Genes
1 uterine carcinosarcoma 30.0 ERBB2 ESR2 FBXW7 PGR PIK3CA PPP2R1A
2 uterine corpus adenocarcinofibroma 11.3
3 endometrioid ovary carcinoma 10.3 ARID1A PPP2R1A
4 prostate squamous cell carcinoma 10.3 PPP2R1A TP53
5 epithelial-myoepithelial carcinoma 10.2 FBXW7 TP53
6 adult hepatocellular carcinoma 10.2 PIK3CA TP53
7 rare adenocarcinoma of the breast 10.2 PIK3CA TP53
8 malignant spiradenoma 10.2 PIK3CA TP53
9 gastric papillary adenocarcinoma 10.1 ERBB2 TP53
10 clear cell adenofibroma 10.1 ARID1A PIK3CA
11 pleomorphic adenoma carcinoma 10.1 ERBB2 TP53
12 non-proliferative fibrocystic change of the breast 10.1 ERBB2 TP53
13 glioma susceptibility 1 10.1 ERBB2 TP53
14 esophagus adenocarcinoma 10.1 ERBB2 TP53
15 granulosa cell tumor of the ovary 10.0 ERBB2 TP53
16 hidradenocarcinoma 10.0 ERBB2 TP53
17 endometrium carcinoma in situ 10.0 PGR TP53
18 anal squamous cell carcinoma 10.0 FBXW7 PIK3CA TP53
19 skin squamous cell carcinoma 10.0 FBXW7 PIK3CA TP53
20 penile cancer 10.0 PIK3CA TP53
21 breast malignant phyllodes tumor 10.0 PGR TP53
22 olfactory groove meningioma 10.0 PGR TP53
23 synchronous bilateral breast carcinoma 10.0 PGR TP53
24 papillary serous adenocarcinoma 10.0 PGR TP53
25 tonsil cancer 10.0 ERBB2 TP53
26 bartholin's gland disease 10.0 PGR TP53
27 female reproductive endometrioid cancer 10.0 PGR TP53
28 cervical carcinosarcoma 10.0 PGR TP53
29 glycogen-rich clear cell breast carcinoma 10.0 PGR TP53
30 barrett's adenocarcinoma 10.0 ERBB2 TP53
31 lobular neoplasia 10.0 ERBB2 ESR2
32 acneiform dermatitis 10.0 ERBB2 PIK3CA
33 anterior cranial fossa meningioma 10.0 PGR TP53
34 adenosarcoma 10.0 PGR TP53
35 adenosquamous lung carcinoma 9.9 ERBB2 PIK3CA
36 progesterone resistance 9.9 ESR2 PGR
37 gender identity disorder 9.9 ESR2 PGR
38 estrogen excess 9.9 ESR2 PGR
39 ovarian clear cell adenocarcinoma 9.9 ARID1A ESR2 PIK3CA
40 scirrhous adenocarcinoma 9.9 ERBB2 PGR
41 breast apocrine carcinoma 9.9 ERBB2 PGR
42 glassy cell carcinoma of the cervix 9.9 ERBB2 PGR
43 papillary hidradenoma 9.9 PGR PIK3CA
44 intracystic papillary adenoma 9.9 ERBB2 PGR
45 breast metaplastic carcinoma 9.9 ERBB2 PGR
46 adenocarcinoma 9.9 ERBB2 PIK3CA TP53
47 progesterone-receptor negative breast cancer 9.9 ERBB2 PGR
48 breast medullary carcinoma 9.9 ERBB2 PGR
49 breast scirrhous carcinoma 9.9 ERBB2 PGR
50 brain stem glioma 9.9 PIK3CA TP53

Graphical network of the top 20 diseases related to Uterine Body Mixed Cancer:



Diseases related to Uterine Body Mixed Cancer

Symptoms & Phenotypes for Uterine Body Mixed Cancer

GenomeRNAi Phenotypes related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

27 (show all 25)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 10.02 ARID1A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-116 10.02 PIK3CA
3 Increased shRNA abundance (Z-score > 2) GR00366-A-12 10.02 TP53
4 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.02 TP53
5 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10.02 TP53
6 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.02 PIK3CA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-16 10.02 PIK3CA
8 Increased shRNA abundance (Z-score > 2) GR00366-A-166 10.02 PIK3CA
9 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.02 ARID1A
10 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.02 TP53
11 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.02 ARID1A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.02 PIK3CA
13 Increased shRNA abundance (Z-score > 2) GR00366-A-186 10.02 ARID1A
14 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.02 TP53
15 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.02 ARID1A PIK3CA TP53
16 Increased shRNA abundance (Z-score > 2) GR00366-A-35 10.02 TP53
17 Increased shRNA abundance (Z-score > 2) GR00366-A-39 10.02 TP53
18 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.02 PIK3CA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.02 ARID1A
20 Increased shRNA abundance (Z-score > 2) GR00366-A-49 10.02 PIK3CA
21 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.02 ARID1A
22 Increased cell death HMECs cells GR00103-A-0 9.55 FBXW7 PGR PIK3CA PPP2R1A TP53
23 Decreased CDKN1A mRNA expression GR00389-S-1 9.43 FBXW7 TP53
24 Decreased CDKN1A mRNA expression GR00389-S-2 9.43 TP53
25 Increased TP53 mRNA expression GR00389-S-6 8.62 ESR2 TP53

MGI Mouse Phenotypes related to Uterine Body Mixed Cancer:

47 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.14 ARID1A ERBB2 ESR2 FBXW7 PGR PIK3CA
2 growth/size/body region MP:0005378 10.1 ARID1A ERBB2 ESR2 FBXW7 PIK3CA PKP3
3 cardiovascular system MP:0005385 10.09 ARID1A ERBB2 ESR2 FBXW7 PGR PIK3CA
4 homeostasis/metabolism MP:0005376 10.08 ARID1A ERBB2 ESR2 FBXW7 PGR PIK3CA
5 endocrine/exocrine gland MP:0005379 10.05 ARID1A ERBB2 ESR2 FBXW7 PGR PIK3CA
6 mortality/aging MP:0010768 10.01 ARID1A ERBB2 ESR2 FBXW7 PGR PIK3CA
7 embryo MP:0005380 10 ARID1A ERBB2 FBXW7 PGR PIK3CA TP53
8 immune system MP:0005387 10 ARID1A ESR2 FBXW7 PGR PIK3CA PKP3
9 integument MP:0010771 9.98 ERBB2 ESR2 FBXW7 PGR PIK3CA PKP3
10 neoplasm MP:0002006 9.92 ARID1A ERBB2 ESR2 FBXW7 PGR PIK3CA
11 muscle MP:0005369 9.85 ARID1A ERBB2 ESR2 PGR PIK3CA TP53
12 normal MP:0002873 9.76 ARID1A ERBB2 ESR2 FBXW7 PGR PKP3
13 no phenotypic analysis MP:0003012 9.65 ARID1A ESR2 PGR PIK3CA TP53
14 reproductive system MP:0005389 9.43 ARID1A ERBB2 ESR2 PGR PIK3CA TP53
15 skeleton MP:0005390 9.1 ARID1A ERBB2 ESR2 PGR PIK3CA TP53

Drugs & Therapeutics for Uterine Body Mixed Cancer

Search Clinical Trials , NIH Clinical Center for Uterine Body Mixed Cancer

Genetic Tests for Uterine Body Mixed Cancer

Anatomical Context for Uterine Body Mixed Cancer

Publications for Uterine Body Mixed Cancer

Variations for Uterine Body Mixed Cancer

Expression for Uterine Body Mixed Cancer

Search GEO for disease gene expression data for Uterine Body Mixed Cancer.

Pathways for Uterine Body Mixed Cancer

Pathways related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.17 ERBB2 FBXW7 PIK3CA PPP2R1A TP53
2
Show member pathways
12.77 ESR2 PGR PIK3CA PPP2R1A
3
Show member pathways
12.72 ERBB2 PIK3CA PPP2R1A TP53
4 12.52 ERBB2 ESR2 PIK3CA TP53
5
Show member pathways
12.4 ERBB2 PIK3CA PPP2R1A TP53
6
Show member pathways
12.37 ERBB2 ESR2 PIK3CA TP53
7
Show member pathways
12.35 ERBB2 PIK3CA TP53
8 12.29 ERBB2 PIK3CA TP53
9
Show member pathways
12.27 ERBB2 PIK3CA TP53
10
Show member pathways
12.26 ERBB2 ESR2 PIK3CA
11
Show member pathways
12.2 PIK3CA PPP2R1A TP53
12
Show member pathways
12.2 ERBB2 PIK3CA TP53
13
Show member pathways
12.1 ARID1A ERBB2 ESR2 PGR PIK3CA TP53
14
Show member pathways
12.09 PGR PIK3CA PPP2R1A
15
Show member pathways
12.05 ERBB2 ESR2 PIK3CA
16 12.02 ERBB2 PIK3CA TP53
17
Show member pathways
11.98 ERBB2 PIK3CA TP53
18 11.84 ERBB2 PIK3CA TP53
19
Show member pathways
11.7 ERBB2 PIK3CA TP53
20 11.66 PIK3CA PPP2R1A TP53
21 11.6 ERBB2 PIK3CA TP53
22
Show member pathways
11.53 ERBB2 PGR PIK3CA
23 11.3 ERBB2 PIK3CA TP53
24 11.14 ERBB2 PIK3CA TP53
25 11.08 ESR2 PGR
26 11.05 ERBB2 PIK3CA
27 10.94 ESR2 PIK3CA
28 10.84 ARID1A ERBB2 FBXW7 PIK3CA TP53

GO Terms for Uterine Body Mixed Cancer

Cellular components related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.56 ARID1A ERBB2 ESR2 FBXW7 PGR PKP3
2 mitochondrion GO:0005739 9.02 ESR2 FBXW7 PGR PPP2R1A TP53

Biological processes related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol 3-kinase signaling GO:0014065 9.32 ERBB2 PIK3CA
2 ERBB2 signaling pathway GO:0038128 9.26 ERBB2 PIK3CA
3 vasculature development GO:0001944 9.16 FBXW7 PIK3CA
4 intracellular estrogen receptor signaling pathway GO:0030520 8.96 ARID1A ESR2
5 negative regulation of cell growth GO:0030308 8.8 ESR2 PPP2R1A TP53

Molecular functions related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.35 ERBB2 ESR2 FBXW7 PGR TP53
2 nuclear receptor activity GO:0004879 9.26 ESR2 PGR
3 steroid binding GO:0005496 9.16 ESR2 PGR
4 enzyme binding GO:0019899 8.92 ESR2 PGR PKP3 TP53

Sources for Uterine Body Mixed Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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