MCID: UTR032
MIFTS: 32

Uterine Body Mixed Cancer

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Uterine Body Mixed Cancer

MalaCards integrated aliases for Uterine Body Mixed Cancer:

Name: Uterine Body Mixed Cancer 12 15
Malignant Mixed Tumor, Not Otherwise Specified 70
Malignant Mixed Tumor of Corpus Uteri 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4114
NCIt 50 C6311
UMLS 70 C1334628 C4054577

Summaries for Uterine Body Mixed Cancer

Disease Ontology : 12 A uterine corpus cancer that has material basis in more than one type of cell.

MalaCards based summary : Uterine Body Mixed Cancer, also known as malignant mixed tumor, not otherwise specified, is related to uterine carcinosarcoma and uterine corpus adenocarcinofibroma. An important gene associated with Uterine Body Mixed Cancer is U2AF1 (U2 Small Nuclear RNA Auxiliary Factor 1), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Affiliated tissues include breast, lung and colon, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Uterine Body Mixed Cancer

Diseases related to Uterine Body Mixed Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 295)
# Related Disease Score Top Affiliating Genes
1 uterine carcinosarcoma 31.1 U2AF1 TP53 RACGAP1 PTEN PPP2R1A POLE
2 uterine corpus adenocarcinofibroma 11.2
3 thyroid hurthle cell adenoma 10.5 PTEN PIK3CA
4 gastric papillary adenocarcinoma 10.4 TP53 ERBB2
5 clear cell adenofibroma 10.4 PPP2R1A PIK3CA ARID1A
6 vulvar intraepithelial neoplasia 10.4 TP53 CTNNB1
7 hepatic flexure cancer 10.4 KRAS HRAS
8 apocrine adenosis of breast 10.4 TP53 ERBB2
9 parameningeal embryonal rhabdomyosarcoma 10.4 TP53 PIK3CA FBXW7
10 breast squamous cell carcinoma 10.4 TP53 ERBB2
11 trachea carcinoma in situ 10.4 KRAS HRAS
12 signet ring basal cell carcinoma 10.4 KRAS HRAS
13 cobblestone retinal degeneration 10.4 KRAS HRAS
14 myoepithelial carcinoma 10.4 TP53 PIK3CA HRAS
15 familial ovarian cancer 10.4 TP53 PTEN POLE
16 immature teratoma of ovary 10.4 KRAS HRAS
17 breast juvenile papillomatosis 10.4 PIK3CA ERBB2
18 spitz nevus 10.4 TP53 HRAS
19 hypertrophy of breast 10.4 TP53 PIK3CA ERBB2
20 ovarian clear cell adenocarcinoma 10.4 TP53 PIK3CA ARID1A
21 clear cell adenocarcinoma 10.4 TP53 PIK3CA ARID1A
22 lung oat cell carcinoma 10.4 TP53 PTEN PIK3CA
23 prostate squamous cell carcinoma 10.4 TP53 PIK3CA HRAS
24 extracutaneous mastocytoma 10.4 U2AF1 KIT
25 testicular gonadoblastoma 10.4 KIT CTNNB1
26 ovarian clear cell adenofibroma 10.4 PTEN PIK3CA KRAS
27 descending colon cancer 10.4 KRAS HRAS
28 gallbladder adenocarcinoma 10.4 TP53 PIK3CA ERBB2
29 ampulla of vater benign neoplasm 10.4 KRAS HRAS
30 parotid gland cancer 10.4 TP53 ERBB2
31 pancreatic signet ring cell adenocarcinoma 10.4 TP53 KRAS HRAS
32 ovarian mucinous neoplasm 10.4 U2AF1 KRAS HRAS
33 bone giant cell sarcoma 10.3 TP53 KRAS HRAS
34 periampullary adenoma 10.3 KRAS HRAS
35 embryonal rhabdomyosarcoma 10.3 TP53 KRAS HRAS
36 biliary tract benign neoplasm 10.3 TP53 KRAS HRAS
37 adenosquamous lung carcinoma 10.3 PIK3CA KRAS HRAS
38 hemimegalencephaly 10.3 PTEN PIK3CA CTNNB1
39 malignant exocrine pancreas neoplasm 10.3 TP53 KRAS HRAS
40 appendix disease 10.3 TP53 KRAS HRAS
41 papillary adenoma 10.3 TP53 KRAS HRAS
42 appendix cancer 10.3 TP53 KRAS HRAS
43 nasal cavity adenocarcinoma 10.3 TP53 KRAS HRAS
44 lobular neoplasia 10.3 TP53 ERBB2 CTNNB1
45 rectosigmoid cancer 10.3 POLE KRAS HRAS
46 oculoectodermal syndrome 10.3 PIK3CA KRAS HRAS
47 breast malignant phyllodes tumor 10.3 TP53 KIT ERBB2
48 liver benign neoplasm 10.3 TP53 HRAS CTNNB1
49 eccrine papillary adenoma 10.3 PIK3CA KRAS HRAS
50 acneiform dermatitis 10.3 KRAS HRAS

Graphical network of the top 20 diseases related to Uterine Body Mixed Cancer:



Diseases related to Uterine Body Mixed Cancer

Symptoms & Phenotypes for Uterine Body Mixed Cancer

GenomeRNAi Phenotypes related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

26 (show all 40)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-1 10.04 POLE
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.04 KRAS
3 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.04 FBXW7
4 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.04 FBXW7
5 Increased shRNA abundance (Z-score > 2) GR00366-A-123 10.04 POLE
6 Increased shRNA abundance (Z-score > 2) GR00366-A-151 10.04 PTEN
7 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.04 KIT
8 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.04 KIT
9 Increased shRNA abundance (Z-score > 2) GR00366-A-16 10.04 PTEN ARID1B
10 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.04 ERBB2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.04 ARID1A ERBB2 POLE PTEN
12 Increased shRNA abundance (Z-score > 2) GR00366-A-170 10.04 KIT
13 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.04 ARID1A
14 Increased shRNA abundance (Z-score > 2) GR00366-A-183 10.04 FBXW7
15 Increased shRNA abundance (Z-score > 2) GR00366-A-186 10.04 ARID1A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.04 ARID1A
17 Increased shRNA abundance (Z-score > 2) GR00366-A-199 10.04 POLE
18 Increased shRNA abundance (Z-score > 2) GR00366-A-207 10.04 ERBB2 POLE
19 Increased shRNA abundance (Z-score > 2) GR00366-A-213 10.04 ARID1A
20 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.04 PTEN
21 Increased shRNA abundance (Z-score > 2) GR00366-A-22 10.04 KRAS
22 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.04 KIT
23 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.04 ERBB2 POLE
24 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.04 PTEN
25 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.04 ARID1A
26 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.04 FBXW7
27 Increased shRNA abundance (Z-score > 2) GR00366-A-60 10.04 ERBB2 PIK3CA
28 Increased shRNA abundance (Z-score > 2) GR00366-A-61 10.04 KIT
29 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.04 ERBB2 KRAS POLE PTEN
30 Increased shRNA abundance (Z-score > 2) GR00366-A-66 10.04 PTEN
31 Increased shRNA abundance (Z-score > 2) GR00366-A-72 10.04 ARID1B
32 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.04 ARID1A
33 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.04 ERBB2 POLE KIT
34 Increased shRNA abundance (Z-score > 2) GR00366-A-87 10.04 ERBB2 POLE PTEN
35 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.04 KIT
36 Increased shRNA abundance (Z-score > 2) GR00366-A-91 10.04 POLE
37 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.04 PTEN
38 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.04 KIT
39 Decreased cell migration GR00055-A-3 9.16 HRAS PIK3CA
40 Increased focal adhesion (FA) area, decreased number of small and round FAs, increased peripheral FA formation, increased cell spreading GR00210-A 8.65 CTNNB1

MGI Mouse Phenotypes related to Uterine Body Mixed Cancer:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.3 ARID1A ARID1B CTNNB1 ERBB2 FAM131A FBXW7
2 cardiovascular system MP:0005385 10.28 ARID1A ARID1B CTNNB1 ERBB2 FBXW7 HRAS
3 mortality/aging MP:0010768 10.24 ARID1A ARID1B CTNNB1 ERBB2 FBXW7 HRAS
4 endocrine/exocrine gland MP:0005379 10.22 ARID1A CTNNB1 ERBB2 FBXW7 HRAS KIT
5 immune system MP:0005387 10.21 ARID1A ARID1B CTNNB1 FBXW7 KIT KRAS
6 embryo MP:0005380 10.19 ARID1A CTNNB1 ERBB2 FBXW7 KIT KRAS
7 craniofacial MP:0005382 10.18 ARID1A ARID1B CTNNB1 ERBB2 FBXW7 HRAS
8 integument MP:0010771 10.18 ARID1B CTNNB1 ERBB2 FBXW7 HRAS KIT
9 digestive/alimentary MP:0005381 10.16 CTNNB1 ERBB2 FBXW7 HRAS KIT KRAS
10 neoplasm MP:0002006 10.07 ARID1A CTNNB1 ERBB2 FBXW7 HRAS KIT
11 muscle MP:0005369 10.02 ARID1A ARID1B CTNNB1 ERBB2 HRAS KIT
12 no phenotypic analysis MP:0003012 9.7 ARID1A CTNNB1 HRAS KIT KRAS PIK3CA
13 normal MP:0002873 9.65 ARID1A CTNNB1 ERBB2 FBXW7 HRAS KIT
14 respiratory system MP:0005388 9.28 CTNNB1 ERBB2 FBXW7 HRAS KIT KRAS

Drugs & Therapeutics for Uterine Body Mixed Cancer

Search Clinical Trials , NIH Clinical Center for Uterine Body Mixed Cancer

Genetic Tests for Uterine Body Mixed Cancer

Anatomical Context for Uterine Body Mixed Cancer

MalaCards organs/tissues related to Uterine Body Mixed Cancer:

40
Breast, Lung, Colon, Thyroid, Skin, Ovary, Myeloid

Publications for Uterine Body Mixed Cancer

Variations for Uterine Body Mixed Cancer

Expression for Uterine Body Mixed Cancer

Search GEO for disease gene expression data for Uterine Body Mixed Cancer.

Pathways for Uterine Body Mixed Cancer

Pathways related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.08 TP53 RACGAP1 PTEN PPP2R1A PIK3CA KRAS
2
Show member pathways
13.45 TP53 RACGAP1 PTEN PPP2R1A PIK3CA KRAS
3
Show member pathways
13.39 TP53 PPP2R1A PIK3CA KRAS KIT HRAS
4
Show member pathways
13.15 TP53 PTEN PPP2R1A PIK3CA KIT ERBB2
5
Show member pathways
12.93 PTEN PIK3CA KRAS HRAS ERBB2 CTNNB1
6
Show member pathways
12.92 TP53 PTEN PPP2R1A PIK3CA KRAS KIT
7 12.8 TP53 KRAS KIT HRAS ERBB2
8
Show member pathways
12.76 PIK3CA KRAS KIT HRAS CTNNB1
9
Show member pathways
12.75 TP53 PTEN PIK3CA MLH1 KRAS HRAS
10
Show member pathways
12.73 TP53 PTEN PIK3CA KRAS HRAS ERBB2
11
Show member pathways
12.71 TP53 PTEN PIK3CA KRAS HRAS ERBB2
12 12.7 TP53 PTEN PIK3CA MLH1 KRAS KIT
13
Show member pathways
12.65 TP53 PTEN PPP2R1A PIK3CA KRAS KIT
14
Show member pathways
12.64 TP53 PIK3CA KRAS HRAS ERBB2 CTNNB1
15 12.57 TP53 PTEN PIK3CA KRAS HRAS ERBB2
16
Show member pathways
12.54 TP53 PTEN PIK3CA KRAS HRAS ERBB2
17
Show member pathways
12.53 TP53 PTEN PIK3CA KRAS HRAS ERBB2
18
Show member pathways
12.52 PTEN PIK3CA KRAS HRAS ERBB2
19
Show member pathways
12.47 TP53 PIK3CA KRAS HRAS ERBB2 CTNNB1
20
Show member pathways
12.44 PTEN PIK3CA KRAS HRAS
21
Show member pathways
12.43 PIK3CA KRAS KIT HRAS
22
Show member pathways
12.43 PIK3CA KRAS HRAS CTNNB1
23
Show member pathways
12.42 TP53 PTEN PIK3CA HRAS
24
Show member pathways
12.42 RACGAP1 PIK3CA KRAS KIT HRAS ERBB2
25
Show member pathways
12.41 TP53 PTEN KRAS HRAS CTNNB1
26 12.4 TP53 PTEN PIK3CA KRAS HRAS
27
Show member pathways
12.37 PIK3CA KRAS HRAS ERBB2 CTNNB1
28
Show member pathways
12.35 PIK3CA KRAS HRAS ERBB2
29 12.33 TP53 PIK3CA KRAS HRAS
30
Show member pathways
12.32 TP53 PTEN PIK3CA HRAS ERBB2 CTNNB1
31
Show member pathways
12.3 PPP2R1A PIK3CA KRAS HRAS
32
Show member pathways
12.28 TP53 PTEN PIK3CA KRAS HRAS ERBB2
33 12.27 TP53 PIK3CA KRAS HRAS ERBB2 CTNNB1
34
Show member pathways
12.26 TP53 RACGAP1 PPP2R1A CTNNB1
35 12.22 TP53 MLH1 KRAS CTNNB1
36 12.22 PTEN KRAS HRAS ERBB2
37 12.22 TP53 PTEN PIK3CA KRAS HRAS
38
Show member pathways
12.21 PTEN PIK3CA KIT HRAS
39
Show member pathways
12.2 TP53 PIK3CA KRAS HRAS
40
Show member pathways
12.19 PTEN PIK3CA KRAS HRAS ERBB2
41 12.18 TP53 PTEN KRAS CTNNB1
42
Show member pathways
12.17 TP53 PIK3CA KRAS HRAS
43 12.14 PIK3CA KRAS HRAS CTNNB1
44
Show member pathways
12.12 PTEN PIK3CA KRAS HRAS
45 12.11 PTEN PIK3CA KRAS HRAS
46 12.04 TP53 PIK3CA KRAS HRAS CTNNB1
47
Show member pathways
12.03 TP53 PTEN PIK3CA MLH1 KRAS KIT
48
Show member pathways
12 PIK3CA KRAS HRAS ERBB2
49 11.99 RACGAP1 PPP2R1A HRAS CTNNB1
50 11.99 TP53 PTEN KRAS HRAS CTNNB1

GO Terms for Uterine Body Mixed Cancer

Cellular components related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.7 U2AF1 TP53 RACGAP1 PTEN POLE MLH1
2 brahma complex GO:0035060 8.62 ARID1B ARID1A

Biological processes related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.8 PTEN KRAS KIT HRAS ERBB2 CTNNB1
2 heart development GO:0007507 9.78 TP53 PTEN ERBB2 CTNNB1
3 liver development GO:0001889 9.69 PIK3CA KRAS HRAS
4 Ras protein signal transduction GO:0007265 9.63 TP53 KRAS HRAS
5 embryonic organ development GO:0048568 9.58 TP53 POLE CTNNB1
6 positive regulation of MAPK cascade GO:0043410 9.56 KIT HRAS ERBB2 CTNNB1
7 phosphatidylinositol 3-kinase signaling GO:0014065 9.54 PTEN PIK3CA ERBB2
8 chromatin-mediated maintenance of transcription GO:0048096 9.49 ARID1B ARID1A
9 response to isolation stress GO:0035900 9.43 KRAS HRAS
10 vasculature development GO:0001944 9.33 PIK3CA FBXW7 CTNNB1
11 positive regulation of MAP kinase activity GO:0043406 9.26 KRAS KIT HRAS ERBB2
12 positive regulation of gene expression GO:0010628 9.17 TP53 PTEN KRAS KIT HRAS ERBB2

Sources for Uterine Body Mixed Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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