MCID: UTR032
MIFTS: 30

Uterine Body Mixed Cancer

Categories: Cancer diseases, Reproductive diseases
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Aliases & Classifications for Uterine Body Mixed Cancer

MalaCards integrated aliases for Uterine Body Mixed Cancer:

Name: Uterine Body Mixed Cancer 11 14
Malignant Mixed Tumor, Not Otherwise Specified 71
Malignant Mixed Tumor of Corpus Uteri 11

Classifications:



External Ids:

Disease Ontology 11 DOID:4114
NCIt 49 C6311
UMLS 71 C1334628 C4054577

Summaries for Uterine Body Mixed Cancer

Disease Ontology: 11 A uterine corpus cancer that has material basis in more than one type of cell.

MalaCards based summary: Uterine Body Mixed Cancer, also known as malignant mixed tumor, not otherwise specified, is related to uterine carcinosarcoma and uterine corpus adenocarcinofibroma. An important gene associated with Uterine Body Mixed Cancer is H2AC18 (H2A Clustered Histone 18), and among its related pathways/superpathways are Gene expression (Transcription) and Innate Immune System. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased cell death in HCT116 cells

Related Diseases for Uterine Body Mixed Cancer

Diseases related to Uterine Body Mixed Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 447)
# Related Disease Score Top Affiliating Genes
1 uterine carcinosarcoma 30.5 U2AF1 TP53 SLC25A16 PTEN PPP2R1A POLE
2 uterine corpus adenocarcinofibroma 11.3
3 esophagus small cell carcinoma 10.5 PIK3CA ERBB2
4 high-grade astrocytoma 10.5 TP53 PTEN
5 familial ovarian cancer 10.4 TP53 POLE
6 wolffian duct adenocarcinoma 10.4 U2AF1 PIK3CA
7 apocrine adenosis of breast 10.4 TP53 ERBB2
8 esophagus verrucous carcinoma 10.4 TP53 PIK3CA
9 apocrine adenocarcinoma 10.4 TP53 PIK3CA ERBB2
10 intraductal breast benign neoplasm 10.4 TP53 PIK3CA ERBB2
11 acute erythroid leukemia 10.4 U2AF1 TP53 H2AC18
12 estrogen-receptor negative breast cancer 10.4 TP53 H2AC18 ERBB2
13 lung oat cell carcinoma 10.4 TP53 PTEN PIK3CA
14 penile benign neoplasm 10.4 TP53 PIK3CA CD274
15 diffuse astrocytoma 10.4 TP53 PTEN H2AC18
16 felty syndrome 10.4 U2AF1 H2AC18 CD8A
17 adenofibroma 10.4 TP53 KRAS ARID1A
18 trachea carcinoma in situ 10.4 KRAS HRAS
19 thoracic benign neoplasm 10.4 TP53 PIK3CA ERBB2
20 localized osteosarcoma 10.4 TP53 ERBB2 CD274
21 keratinizing squamous cell carcinoma 10.4 TP53 PIK3CA HRAS
22 synchronous bilateral breast carcinoma 10.4 TP53 PTEN ERBB2
23 clear cell adenofibroma 10.4 PIK3CA ARID1A
24 blastoma 10.4 TP53 KRAS HRAS
25 anogenital venereal wart 10.4 TP53 H2AC18 CD8A
26 gastroesophageal junction adenocarcinoma 10.4 TP53 ERBB2 CD274
27 immune-complex glomerulonephritis 10.4 ICOSLG H2AC18 CD8A
28 parotid gland cancer 10.4 TP53 ERBB2
29 mixed oligodendroglioma-astrocytoma 10.4 TP53 PTEN CD274
30 gallbladder adenocarcinoma 10.4 TP53 HRAS ERBB2
31 t-cell prolymphocytic leukemia 10.4 TP53 H2AC18 CD8A
32 common bile duct neoplasm 10.4 KRAS HRAS
33 autoimmune disease of urogenital tract 10.4 ICOSLG H2AC18 CD8A
34 autosomal recessive cerebellar ataxia 10.4 U2AF1 TP53 H2AC18
35 rhabdoid cancer 10.4 TP53 H2AC18 ARID1A
36 breast myoepithelial neoplasm 10.4 PIK3CA HRAS
37 primary thrombocytopenia 10.4 U2AF1 ICOSLG CD8A
38 breast adenomyoepithelioma 10.4 PIK3CA HRAS
39 splenic disease 10.4 U2AF1 H2AC18 CD8A
40 lip and oral cavity cancer 10.4 TP53 PIK3CA HRAS
41 immunodeficiency 14 10.4 PIK3CA ICOSLG CD8A
42 actinic keratosis 10.4 TP53 H2AC18 CD8A
43 ovarian serous carcinoma 10.4 TP53 HRAS H2AC18
44 lymphoepithelioma-like carcinoma 10.4 TP53 CD8A CD274
45 nodular malignant melanoma 10.4 TP53 PTEN HRAS
46 ampulla of vater benign neoplasm 10.4 KRAS HRAS
47 rectum signet ring adenocarcinoma 10.4 MSH2 MLH1
48 chronic leukemia 10.4 U2AF1 HRAS H2AC18
49 west nile encephalitis 10.4 ICOSLG H2AC18 CD8A
50 malignant spindle cell melanoma 10.4 TP53 HRAS CD274

Graphical network of the top 20 diseases related to Uterine Body Mixed Cancer:



Diseases related to Uterine Body Mixed Cancer

Symptoms & Phenotypes for Uterine Body Mixed Cancer

GenomeRNAi Phenotypes related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

25 (show all 44)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-1 10.62 POLE
2 Increased shRNA abundance (Z-score > 2) GR00366-A-116 10.62 MSH2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.62 KRAS
4 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.62 FBXW7
5 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.62 FBXW7
6 Increased shRNA abundance (Z-score > 2) GR00366-A-123 10.62 POLE
7 Increased shRNA abundance (Z-score > 2) GR00366-A-14 10.62 MSH2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-151 10.62 PTEN MSH2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-16 10.62 PTEN
10 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.62 ERBB2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.62 ERBB2 POLE PTEN ARID1A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.62 ARID1A MSH2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-183 10.62 FBXW7
14 Increased shRNA abundance (Z-score > 2) GR00366-A-186 10.62 ARID1A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.62 ARID1A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-196 10.62 HRAS
17 Increased shRNA abundance (Z-score > 2) GR00366-A-199 10.62 POLE
18 Increased shRNA abundance (Z-score > 2) GR00366-A-207 10.62 ERBB2 POLE
19 Increased shRNA abundance (Z-score > 2) GR00366-A-213 10.62 ARID1A
20 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.62 PTEN MSH2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-22 10.62 KRAS
22 Increased shRNA abundance (Z-score > 2) GR00366-A-28 10.62 HRAS
23 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.62 ERBB2 POLE
24 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.62 PTEN
25 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.62 ARID1A
26 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.62 FBXW7
27 Increased shRNA abundance (Z-score > 2) GR00366-A-53 10.62 MSH2
28 Increased shRNA abundance (Z-score > 2) GR00366-A-60 10.62 ERBB2
29 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.62 ERBB2 POLE PTEN KRAS
30 Increased shRNA abundance (Z-score > 2) GR00366-A-66 10.62 PTEN
31 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.62 ARID1A
32 Increased shRNA abundance (Z-score > 2) GR00366-A-82 10.62 H2AC18
33 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.62 HRAS
34 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.62 ERBB2 POLE
35 Increased shRNA abundance (Z-score > 2) GR00366-A-87 10.62 ERBB2 HRAS POLE PTEN
36 Increased shRNA abundance (Z-score > 2) GR00366-A-91 10.62 POLE
37 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.62 PTEN
38 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.62 H2AC18
39 no effect GR00402-S-1 10.18 ARID1A CD274 CD8A CTNNB1 ERBB2 FBXW7
40 no effect GR00402-S-2 10.18 ARID1A CD274 CTNNB1 ERBB2 FBXW7 H2AC18
41 Increased cell death in HCT116 cells GR00103-A-0 9.56 CTNNB1 FBXW7 PIK3CA PPP2R1A
42 Increased cell migration GR00055-A-1 9.32 CTNNB1
43 Increased cell migration GR00055-A-3 9.32 CTNNB1
44 Decreased viability in pancreas lineage GR00235-A 9.16 ARID1A TP53

MGI Mouse Phenotypes related to Uterine Body Mixed Cancer:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 10.4 ARID1A CTNNB1 ERBB2 FBXW7 HRAS KRAS
2 homeostasis/metabolism MP:0005376 10.36 ARID1A CD274 CTNNB1 ERBB2 FBXW7 HRAS
3 normal MP:0002873 10.21 ARID1A CD8A CTNNB1 ERBB2 FBXW7 HRAS
4 immune system MP:0005387 10.2 ARID1A CD274 CD8A CTNNB1 FBXW7 ICOSLG
5 cellular MP:0005384 10.18 ARID1A CD274 CD8A CTNNB1 ERBB2 FBXW7
6 endocrine/exocrine gland MP:0005379 10.17 ARID1A CD8A CTNNB1 ERBB2 FBXW7 HRAS
7 digestive/alimentary MP:0005381 10.1 CTNNB1 ERBB2 FBXW7 HRAS KRAS MLH1
8 muscle MP:0005369 10.08 ARID1A CTNNB1 ERBB2 HRAS KRAS PIK3CA
9 no phenotypic analysis MP:0003012 10.04 ARID1A CD274 CTNNB1 HRAS KRAS PIK3CA
10 hematopoietic system MP:0005397 10.03 ARID1A CD274 CD8A CTNNB1 ERBB2 FBXW7
11 mortality/aging MP:0010768 9.89 ARID1A CD274 CD8A CTNNB1 ERBB2 FBXW7
12 respiratory system MP:0005388 9.86 CTNNB1 ERBB2 FBXW7 HRAS KRAS MLH1
13 integument MP:0010771 9.5 CD274 CD8A CTNNB1 ERBB2 FBXW7 HRAS

Drugs & Therapeutics for Uterine Body Mixed Cancer

Search Clinical Trials, NIH Clinical Center for Uterine Body Mixed Cancer

Genetic Tests for Uterine Body Mixed Cancer

Anatomical Context for Uterine Body Mixed Cancer

Publications for Uterine Body Mixed Cancer

Variations for Uterine Body Mixed Cancer

Expression for Uterine Body Mixed Cancer

Search GEO for disease gene expression data for Uterine Body Mixed Cancer.

Pathways for Uterine Body Mixed Cancer

Pathways related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.08 U2AF1 TP53 PTEN PPP2R1A MSH2 MLH1
2
Show member pathways
13.99 TP53 PTEN PPP2R1A PIK3CA KRAS ICOSLG
3 13.78 CD274 CTNNB1 ERBB2 FBXW7 H2AC18 HRAS
4
Show member pathways
13.68 TP53 PTEN PPP2R1A PIK3CA MSH6 MSH2
5
Show member pathways
13.53 CD274 CD8A FBXW7 HRAS ICOSLG KRAS
6
Show member pathways
13.49 CTNNB1 ERBB2 HRAS KRAS MSH6 PIK3CA
7
Show member pathways
13.38 PTEN PPP2R1A PIK3CA KRAS HRAS FBXW7
8
Show member pathways
12.97 TP53 PTEN PPP2R1A PIK3CA KRAS HRAS
9
Show member pathways
12.94 TP53 MSH6 MSH2 MLH1 KRAS HRAS
10
Show member pathways
12.88 PTEN PIK3CA KRAS HRAS ERBB2
11 12.85 PPP2R1A PIK3CA KRAS HRAS ERBB2 CTNNB1
12 12.72 TP53 PTEN PIK3CA HRAS CTNNB1 CD274
13
Show member pathways
12.62 FBXW7 MSH2 MSH6 POLE TP53
14 12.53 MLH1 MSH2 MSH6 PPP2R1A TP53
15
Show member pathways
12.53 CTNNB1 ERBB2 HRAS KRAS MSH2 PIK3CA
16
Show member pathways
12.48 TP53 PTEN PIK3CA HRAS ERBB2 CTNNB1
17
Show member pathways
12.47 TP53 PIK3CA KRAS HRAS ERBB2 CTNNB1
18
Show member pathways
12.47 CTNNB1 ERBB2 HRAS KRAS MLH1 MSH2
19
Show member pathways
12.46 TP53 PIK3CA KRAS HRAS ERBB2 CTNNB1
20
Show member pathways
12.44 MLH1 MSH2 MSH6 POLE
21
Show member pathways
12.42 PIK3CA KRAS HRAS CTNNB1
22
Show member pathways
12.41 CTNNB1 ERBB2 HRAS KRAS PIK3CA
23
Show member pathways
12.38 PPP2R1A PIK3CA ICOSLG CTNNB1 CD8A CD274
24
Show member pathways
12.34 PTEN PIK3CA KRAS HRAS
25
Show member pathways
12.34 PIK3CA KRAS HRAS CTNNB1
26 12.32 PTEN PIK3CA HRAS ERBB2 CTNNB1
27
Show member pathways
12.3 TP53 PTEN PIK3CA KRAS HRAS ERBB2
28
Show member pathways
12.29 PPP2R1A PIK3CA KRAS HRAS
29
Show member pathways
12.28 TP53 PTEN PIK3CA HRAS
30
Show member pathways
12.27 PIK3CA KRAS HRAS ERBB2
31
Show member pathways
12.25 ERBB2 HRAS KRAS PIK3CA PTEN TP53
32 12.22 CTNNB1 HRAS KRAS PIK3CA TP53
33
Show member pathways
12.18 TP53 PTEN PIK3CA HRAS CD8A
34
Show member pathways
12.16 PTEN PIK3CA HRAS ERBB2 CTNNB1
35 12.12 TP53 PTEN KRAS ERBB2
36
Show member pathways
12.1 PIK3CA KRAS HRAS ERBB2
37 12.1 CTNNB1 KRAS MLH1 MSH2 MSH6 TP53
38 12.08 TP53 PTEN MSH2 MLH1
39
Show member pathways
12.06 PIK3CA KRAS HRAS ERBB2
40 12.02 TP53 PTEN MSH6 MSH2 KRAS CTNNB1
41 12 PIK3CA KRAS HRAS CTNNB1
42
Show member pathways
11.98 ERBB2 HRAS KRAS PIK3CA PTEN
43
Show member pathways
11.88 PIK3CA KRAS HRAS
44
Show member pathways
11.86 PIK3CA KRAS HRAS
45 11.86 TP53 PIK3CA HRAS CTNNB1
46 11.85 TP53 POLE MSH6
47
Show member pathways
11.84 TP53 MSH6 MSH2
48
Show member pathways
11.84 TP53 PIK3CA KRAS HRAS
49 11.82 TP53 MSH2 MLH1
50
Show member pathways
11.81 PIK3CA KRAS HRAS

GO Terms for Uterine Body Mixed Cancer

Cellular components related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromosome GO:0005694 9.56 PPP2R1A MSH6 MSH2 MLH1 H2AC18 FBXW7
2 MutSalpha complex GO:0032301 8.92 MSH6 MSH2

Biological processes related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 T cell receptor signaling pathway GO:0050852 10.06 PIK3CA ICOSLG HRAS CD8A
2 phosphatidylinositol 3-kinase signaling GO:0014065 10.01 PTEN PIK3CA ERBB2
3 cellular response to DNA damage stimulus GO:0006974 9.98 FBXW7 MLH1 MSH2 MSH6 POLE TP53
4 intrinsic apoptotic signaling pathway GO:0097193 9.95 TP53 MSH6 HRAS
5 embryonic organ development GO:0048568 9.92 TP53 POLE CTNNB1
6 mismatch repair GO:0006298 9.88 MSH6 MSH2 MLH1
7 positive regulation of helicase activity GO:0051096 9.85 MSH6 MSH2
8 positive regulation of isotype switching to IgA isotypes GO:0048298 9.81 MSH2 MLH1
9 determination of adult lifespan GO:0008340 9.8 MSH2 MSH6 TP53
10 vasculature development GO:0001944 9.77 PIK3CA FBXW7 CTNNB1
11 isotype switching GO:0045190 9.73 MSH6 MSH2 MLH1
12 maintenance of DNA repeat elements GO:0043570 9.67 MSH6 MSH2
13 somatic hypermutation of immunoglobulin genes GO:0016446 9.43 MSH6 MSH2 MLH1
14 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.33 MSH2 MLH1
15 somatic recombination of immunoglobulin gene segments GO:0016447 9.02 MSH6 MSH2 MLH1

Molecular functions related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 10.21 TP53 POLE MSH6 MSH2 MLH1 CTNNB1
2 enzyme binding GO:0019899 10.15 CTNNB1 MLH1 MSH2 MSH6 PTEN TP53
3 nucleotide binding GO:0000166 10.06 POLE PIK3CA MSH6 MSH2 MLH1 KRAS
4 ATP-dependent DNA damage sensor activity GO:0140664 9.63 MSH6 MSH2 MLH1
5 single guanine insertion binding GO:0032142 9.62 MSH6 MSH2
6 single thymine insertion binding GO:0032143 9.56 MSH6 MSH2
7 mismatched DNA binding GO:0030983 9.35 MSH6 MSH2 MLH1
8 guanine/thymine mispair binding GO:0032137 9.1 MSH6 MSH2 MLH1

Sources for Uterine Body Mixed Cancer

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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