Uterine Body Mixed Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Uterine Body Mixed Cancer

MalaCards integrated aliases for Uterine Body Mixed Cancer:

Name: Uterine Body Mixed Cancer ¹¹ ¹⁴

Malignant Mixed Tumor, Not Otherwise Specified ⁷¹

Malignant Mixed Tumor of Corpus Uteri ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:4114

NCIt ⁴⁹ C6311

UMLS ⁷¹ C1334628 C4054577

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Summaries for Uterine Body Mixed Cancer

Disease Ontology: ¹¹ A uterine corpus cancer that has material basis in more than one type of cell.

MalaCards based summary: Uterine Body Mixed Cancer, also known as malignant mixed tumor, not otherwise specified, is related to uterine carcinosarcoma and uterine corpus adenocarcinofibroma. An important gene associated with Uterine Body Mixed Cancer is H2AC18 (H2A Clustered Histone 18), and among its related pathways/superpathways are Gene expression (Transcription) and Innate Immune System. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased cell death in HCT116 cells

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Related Diseases for Uterine Body Mixed Cancer

Diseases related to Uterine Body Mixed Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 447)

#	Related Disease	Score	Top Affiliating Genes
1	uterine carcinosarcoma	30.5	U2AF1 TP53 SLC25A16 PTEN PPP2R1A POLE
2	uterine corpus adenocarcinofibroma	11.3
3	esophagus small cell carcinoma	10.5	PIK3CA ERBB2
4	high-grade astrocytoma	10.5	TP53 PTEN
5	familial ovarian cancer	10.4	TP53 POLE
6	wolffian duct adenocarcinoma	10.4	U2AF1 PIK3CA
7	apocrine adenosis of breast	10.4	TP53 ERBB2
8	esophagus verrucous carcinoma	10.4	TP53 PIK3CA
9	apocrine adenocarcinoma	10.4	TP53 PIK3CA ERBB2
10	intraductal breast benign neoplasm	10.4	TP53 PIK3CA ERBB2
11	acute erythroid leukemia	10.4	U2AF1 TP53 H2AC18
12	estrogen-receptor negative breast cancer	10.4	TP53 H2AC18 ERBB2
13	lung oat cell carcinoma	10.4	TP53 PTEN PIK3CA
14	penile benign neoplasm	10.4	TP53 PIK3CA CD274
15	diffuse astrocytoma	10.4	TP53 PTEN H2AC18
16	felty syndrome	10.4	U2AF1 H2AC18 CD8A
17	adenofibroma	10.4	TP53 KRAS ARID1A
18	trachea carcinoma in situ	10.4	KRAS HRAS
19	thoracic benign neoplasm	10.4	TP53 PIK3CA ERBB2
20	localized osteosarcoma	10.4	TP53 ERBB2 CD274
21	keratinizing squamous cell carcinoma	10.4	TP53 PIK3CA HRAS
22	synchronous bilateral breast carcinoma	10.4	TP53 PTEN ERBB2
23	clear cell adenofibroma	10.4	PIK3CA ARID1A
24	blastoma	10.4	TP53 KRAS HRAS
25	anogenital venereal wart	10.4	TP53 H2AC18 CD8A
26	gastroesophageal junction adenocarcinoma	10.4	TP53 ERBB2 CD274
27	immune-complex glomerulonephritis	10.4	ICOSLG H2AC18 CD8A
28	parotid gland cancer	10.4	TP53 ERBB2
29	mixed oligodendroglioma-astrocytoma	10.4	TP53 PTEN CD274
30	gallbladder adenocarcinoma	10.4	TP53 HRAS ERBB2
31	t-cell prolymphocytic leukemia	10.4	TP53 H2AC18 CD8A
32	common bile duct neoplasm	10.4	KRAS HRAS
33	autoimmune disease of urogenital tract	10.4	ICOSLG H2AC18 CD8A
34	autosomal recessive cerebellar ataxia	10.4	U2AF1 TP53 H2AC18
35	rhabdoid cancer	10.4	TP53 H2AC18 ARID1A
36	breast myoepithelial neoplasm	10.4	PIK3CA HRAS
37	primary thrombocytopenia	10.4	U2AF1 ICOSLG CD8A
38	breast adenomyoepithelioma	10.4	PIK3CA HRAS
39	splenic disease	10.4	U2AF1 H2AC18 CD8A
40	lip and oral cavity cancer	10.4	TP53 PIK3CA HRAS
41	immunodeficiency 14	10.4	PIK3CA ICOSLG CD8A
42	actinic keratosis	10.4	TP53 H2AC18 CD8A
43	ovarian serous carcinoma	10.4	TP53 HRAS H2AC18
44	lymphoepithelioma-like carcinoma	10.4	TP53 CD8A CD274
45	nodular malignant melanoma	10.4	TP53 PTEN HRAS
46	ampulla of vater benign neoplasm	10.4	KRAS HRAS
47	rectum signet ring adenocarcinoma	10.4	MSH2 MLH1
48	chronic leukemia	10.4	U2AF1 HRAS H2AC18
49	west nile encephalitis	10.4	ICOSLG H2AC18 CD8A
50	malignant spindle cell melanoma	10.4	TP53 HRAS CD274

Graphical network of the top 20 diseases related to Uterine Body Mixed Cancer:

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Symptoms & Phenotypes for Uterine Body Mixed Cancer

GenomeRNAi Phenotypes related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

²⁵ (show all 44)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-1	10.62	POLE
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-116	10.62	MSH2
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-120	10.62	KRAS
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-121	10.62	FBXW7
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-122	10.62	FBXW7
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-123	10.62	POLE
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-14	10.62	MSH2
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-151	10.62	PTEN MSH2
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-16	10.62	PTEN
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-161	10.62	ERBB2
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-168	10.62	ERBB2 POLE PTEN ARID1A
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-176	10.62	ARID1A MSH2
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-183	10.62	FBXW7
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-186	10.62	ARID1A
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-190	10.62	ARID1A
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-196	10.62	HRAS
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-199	10.62	POLE
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-207	10.62	ERBB2 POLE
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-213	10.62	ARID1A
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-214	10.62	PTEN MSH2
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-22	10.62	KRAS
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-28	10.62	HRAS
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-32	10.62	ERBB2 POLE
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-42	10.62	PTEN
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-43	10.62	ARID1A
26	Increased shRNA abundance (Z-score > 2)	GR00366-A-52	10.62	FBXW7
27	Increased shRNA abundance (Z-score > 2)	GR00366-A-53	10.62	MSH2
28	Increased shRNA abundance (Z-score > 2)	GR00366-A-60	10.62	ERBB2
29	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	10.62	ERBB2 POLE PTEN KRAS
30	Increased shRNA abundance (Z-score > 2)	GR00366-A-66	10.62	PTEN
31	Increased shRNA abundance (Z-score > 2)	GR00366-A-73	10.62	ARID1A
32	Increased shRNA abundance (Z-score > 2)	GR00366-A-82	10.62	H2AC18
33	Increased shRNA abundance (Z-score > 2)	GR00366-A-83	10.62	HRAS
34	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	10.62	ERBB2 POLE
35	Increased shRNA abundance (Z-score > 2)	GR00366-A-87	10.62	ERBB2 HRAS POLE PTEN
36	Increased shRNA abundance (Z-score > 2)	GR00366-A-91	10.62	POLE
37	Increased shRNA abundance (Z-score > 2)	GR00366-A-93	10.62	PTEN
38	Increased shRNA abundance (Z-score > 2)	GR00366-A-99	10.62	H2AC18
39	no effect	GR00402-S-1	10.18	ARID1A CD274 CD8A CTNNB1 ERBB2 FBXW7
40	no effect	GR00402-S-2	10.18	ARID1A CD274 CTNNB1 ERBB2 FBXW7 H2AC18
41	Increased cell death in HCT116 cells	GR00103-A-0	9.56	CTNNB1 FBXW7 PIK3CA PPP2R1A
42	Increased cell migration	GR00055-A-1	9.32	CTNNB1
43	Increased cell migration	GR00055-A-3	9.32	CTNNB1
44	Decreased viability in pancreas lineage	GR00235-A	9.16	ARID1A TP53

MGI Mouse Phenotypes related to Uterine Body Mixed Cancer:

⁴⁵ (show all 13)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	10.4	ARID1A CTNNB1 ERBB2 FBXW7 HRAS KRAS
2	homeostasis/metabolism	MP:0005376	10.36	ARID1A CD274 CTNNB1 ERBB2 FBXW7 HRAS
3	normal	MP:0002873	10.21	ARID1A CD8A CTNNB1 ERBB2 FBXW7 HRAS
4	immune system	MP:0005387	10.2	ARID1A CD274 CD8A CTNNB1 FBXW7 ICOSLG
5	cellular	MP:0005384	10.18	ARID1A CD274 CD8A CTNNB1 ERBB2 FBXW7
6	endocrine/exocrine gland	MP:0005379	10.17	ARID1A CD8A CTNNB1 ERBB2 FBXW7 HRAS
7	digestive/alimentary	MP:0005381	10.1	CTNNB1 ERBB2 FBXW7 HRAS KRAS MLH1
8	muscle	MP:0005369	10.08	ARID1A CTNNB1 ERBB2 HRAS KRAS PIK3CA
9	no phenotypic analysis	MP:0003012	10.04	ARID1A CD274 CTNNB1 HRAS KRAS PIK3CA
10	hematopoietic system	MP:0005397	10.03	ARID1A CD274 CD8A CTNNB1 ERBB2 FBXW7
11	mortality/aging	MP:0010768	9.89	ARID1A CD274 CD8A CTNNB1 ERBB2 FBXW7
12	respiratory system	MP:0005388	9.86	CTNNB1 ERBB2 FBXW7 HRAS KRAS MLH1
13	integument	MP:0010771	9.5	CD274 CD8A CTNNB1 ERBB2 FBXW7 HRAS

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Drugs & Therapeutics for Uterine Body Mixed Cancer

Search Clinical Trials, NIH Clinical Center for Uterine Body Mixed Cancer

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Genetic Tests for Uterine Body Mixed Cancer

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Anatomical Context for Uterine Body Mixed Cancer

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Publications for Uterine Body Mixed Cancer

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Genes for Uterine Body Mixed Cancer

Genes related to Uterine Body Mixed Cancer (0 elite genes):

(show all 36)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	H2AC18	H2A Clustered Histone 18	Protein Coding	7.12	DISEASES inferred ¹⁴ ¹⁴
2	U2AF1	U2 Small Nuclear RNA Auxiliary Factor 1	Protein Coding	6.63	DISEASES inferred ¹⁴ ¹⁴
3	SLC25A16	Solute Carrier Family 25 Member 16	Protein Coding	6.29	DISEASES inferred ¹⁴
4	TP53	Tumor Protein P53	Protein Coding	6.28	DISEASES inferred ¹⁴
5	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	6.2	DISEASES inferred ¹⁴
6	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	6.1	DISEASES inferred ¹⁴
7	POLE	DNA Polymerase Epsilon, Catalytic Subunit	Protein Coding	6.05	DISEASES inferred ¹⁴
8	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	6.03	DISEASES inferred ¹⁴ ¹⁴
9	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	5.94	DISEASES inferred ¹⁴
10	FBXW7	F-Box And WD Repeat Domain Containing 7	Protein Coding	5.91	DISEASES inferred ¹⁴
11	ARID1A	AT-Rich Interaction Domain 1A	Protein Coding	5.9	DISEASES inferred ¹⁴
12	PTEN	Phosphatase And Tensin Homolog	Protein Coding	5.85	DISEASES inferred ¹⁴
13	CD274	CD274 Molecule	Protein Coding	5.7	DISEASES inferred ¹⁴
14	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	5.64	DISEASES inferred ¹⁴
15	CD8A	CD8a Molecule	Protein Coding	5.57	DISEASES inferred ¹⁴
16	MSH2	MutS Homolog 2	Protein Coding	5.55	DISEASES inferred ¹⁴
17	MLH1	MutL Homolog 1	Protein Coding	5.54	DISEASES inferred ¹⁴
18	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	5.51	DISEASES inferred ¹⁴
19	MSH6	MutS Homolog 6	Protein Coding	5.5	DISEASES inferred ¹⁴
20	CTNNB1	Catenin Beta 1	Protein Coding	5.48	DISEASES inferred ¹⁴
21	PMS2	PMS1 Homolog 2, Mismatch Repair System Component	Protein Coding	5.42	DISEASES inferred ¹⁴
22	EGFR	Epidermal Growth Factor Receptor	Protein Coding	5.41	DISEASES inferred ¹⁴
23	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	5.36	DISEASES inferred ¹⁴
24	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	5.28	DISEASES inferred ¹⁴
25	ESR1	Estrogen Receptor 1	Protein Coding	5.28	DISEASES inferred ¹⁴
26	RACGAP1	Rac GTPase Activating Protein 1	Protein Coding	5.28	DISEASES inferred ¹⁴
27	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	5.22	DISEASES inferred ¹⁴
28	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	5.21	DISEASES inferred ¹⁴
29	PDCD1	Programmed Cell Death 1	Protein Coding	5.18	DISEASES inferred ¹⁴
30	CCNE1	Cyclin E1	Protein Coding	5.11	DISEASES inferred ¹⁴
31	MC3R	Melanocortin 3 Receptor	Protein Coding	5.08	DISEASES inferred ¹⁴
32	CD4	CD4 Molecule	Protein Coding	5.08	DISEASES inferred ¹⁴
33	CDH1	Cadherin 1	Protein Coding	5	DISEASES inferred ¹⁴
34	LAG3	Lymphocyte Activating 3	Protein Coding	4.97	DISEASES inferred ¹⁴
35	PDCD1LG2	Programmed Cell Death 1 Ligand 2	Protein Coding	4.95	DISEASES inferred ¹⁴
36	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	4.95	DISEASES inferred ¹⁴

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Variations for Uterine Body Mixed Cancer

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Expression for Uterine Body Mixed Cancer

Search GEO for disease gene expression data for Uterine Body Mixed Cancer.

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Pathways for Uterine Body Mixed Cancer

Pathways related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 73)

#	Super pathways	Score	Top Affiliating Genes
1	Gene expression (Transcription) ⁶⁶ Show member pathways Generic Transcription Pathway ⁶⁶ RNA Polymerase II Transcription ⁶⁶	14.08	U2AF1 TP53 PTEN PPP2R1A MSH2 MLH1
2	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.99	TP53 PTEN PPP2R1A PIK3CA KRAS ICOSLG
3	Signal Transduction ⁶⁶	13.78	CD274 CTNNB1 ERBB2 FBXW7 H2AC18 HRAS
4	Disease ⁶⁶ Show member pathways Infectious disease ⁶⁶	13.68	TP53 PTEN PPP2R1A PIK3CA MSH6 MSH2
5	Class I MHC mediated antigen processing and presentation ⁶⁶ Show member pathways Adaptive Immune System ⁶⁶ Antigen processing: Ubiquitination and Proteasome degradation ⁶⁶ Neddylation ⁶⁶	13.53	CD274 CD8A FBXW7 HRAS ICOSLG KRAS
6	Prolactin Signaling ⁶⁴ Show member pathways Development Prolactin receptor signaling ²² EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ⁷⁴ ErbB Family Pathway ⁶⁴ ErbB signaling pathway ⁷⁴ ErbB2-ErbB3 Heterodimers ⁶⁴ ErbB4 Pathway ⁶⁴ Estrogen-stimulated signaling through PRKCZ ⁶⁶ Glioblastoma Multiforme ⁶⁴ Glioblastoma signaling pathways ⁷⁴ Growth Hormone Signaling ⁶⁴ HMGB1 Pathway ⁶⁴ IL-2 Pathway ⁶⁴ LPS Stimulated MAPK Signaling ⁶⁴ PACAP Signaling ⁶⁴ PI3K Signaling in B-Lymphocyte ⁶⁴ TCA cycle nutrient use and invasiveness of ovarian cancer ⁷⁴ Thrombopoietin Pathway ⁶⁴ TREM1 Pathway ⁶⁴ UVA-Induced MAPK Signaling ⁶⁴ UVB-Induced MAPK Signaling ⁶⁴ UVC-Induced MAPK Signaling ⁶⁴	13.49	CTNNB1 ERBB2 HRAS KRAS MSH6 PIK3CA
7	RAF/MAP kinase cascade ⁶⁶ Show member pathways Diseases of signal transduction by growth factor receptors and second messengers ⁶⁶ MAPK family signaling cascades ⁶⁶ MAPK1/MAPK3 signaling ⁶⁶	13.38	PTEN PPP2R1A PIK3CA KRAS HRAS FBXW7
8	PI3K-Akt signaling pathway ⁷⁴ Show member pathways Focal adhesion: PI3K-Akt-mTOR-signaling pathway ⁷⁴	12.97	TP53 PTEN PPP2R1A PIK3CA KRAS HRAS
9	TCR Signaling (Qiagen) ⁶⁴ Show member pathways Fc-EpsilonRI Pathway ⁶⁴ ITK and TCR Signaling ⁶⁴ PDGF Pathway ⁶⁴ PKC-Theta Pathway ⁶⁴	12.94	TP53 MSH6 MSH2 MLH1 KRAS HRAS
10	NFAT and Cardiac Hypertrophy ⁶⁴ Show member pathways IGF1R Signaling ⁶⁴ Signaling Involved in Cardiac Hypertrophy ⁶⁴	12.88	PTEN PIK3CA KRAS HRAS ERBB2
11	Signaling by Receptor Tyrosine Kinases ⁶⁶	12.85	PPP2R1A PIK3CA KRAS HRAS ERBB2 CTNNB1
12	Malignant pleural mesothelioma ⁷⁴	12.72	TP53 PTEN PIK3CA HRAS CTNNB1 CD274
13	Chks in Checkpoint Regulation ⁶⁴ Show member pathways DNA Repair Mechanisms ⁶⁴ Estrogen-mediated S-Phase Entry ⁶⁴ G2-M Phase Transition ⁶⁴ SREBP Proteolysis ⁶⁴	12.62	FBXW7 MSH2 MSH6 POLE TP53
14	DNA Damage ³	12.53	MLH1 MSH2 MSH6 PPP2R1A TP53
15	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.53	CTNNB1 ERBB2 HRAS KRAS MSH2 PIK3CA
16	Hepatocyte growth factor receptor signaling ⁷⁴ Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²² Apoptosis and survival NGF signaling pathway ²² Apoptosis and survival Role of CDK5 in neuronal death and survival ²² Development HGF signaling pathway ²² Development Neurotrophin family signaling ²² Drug-mediated inhibition of MET activation ⁶⁶ MET activates PTPN11 ⁶⁶ MET activates STAT3 ⁶⁶ PLC-gamma1 signalling ⁶⁶ Trk receptor signaling mediated by PI3K and PLC-gamma ⁶¹ TRKA activation by NGF ⁶⁶	12.48	TP53 PTEN PIK3CA HRAS ERBB2 CTNNB1
17	Development EGFR signaling pathway ²² Show member pathways Development ERBB-family signaling ²² EGF Pathway ⁶⁴ EGFR Signaling Pathway ⁶⁷ ErbB receptor signaling network ⁶¹	12.47	TP53 PIK3CA KRAS HRAS ERBB2 CTNNB1
18	Endometrial cancer ⁷⁴ Show member pathways Chromosomal and microsatellite instability in colorectal cancer ⁷⁴ Melanoma ⁷⁴ Non-small cell lung cancer ⁷⁴ Pancreatic adenocarcinoma pathway ⁷⁴ Signal transduction PTEN pathway ²²	12.47	CTNNB1 ERBB2 HRAS KRAS MLH1 MSH2
19	NF-kappaB Pathway ⁷⁰ Show member pathways Akt Pathway ⁷⁰ Apoptosis Pathway ⁷⁰	12.46	TP53 PIK3CA KRAS HRAS ERBB2 CTNNB1
20	Base excision repair ⁷⁴ Show member pathways Abasic sugar-phosphate removal via the single-nucleotide replacement pathway ⁶⁶ APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway ⁶⁶ Cell cycle Transition and termination of DNA replication ²² Displacement of DNA glycosylase by APEX1 ⁶⁶ DNA mismatch repair ⁷⁴ Gap-filling DNA repair synthesis and ligation in GG-NER ⁶⁶ Mismatch Repair in Eukaryotes ⁶⁴ PCNA-Dependent Long Patch Base Excision Repair ⁶⁶ POLB-Dependent Long Patch Base Excision Repair ⁶⁶ Resolution of Abasic Sites (AP sites) ⁶⁶ Resolution of AP sites via the multiple-nucleotide patch replacement pathway ⁶⁶ Resolution of AP sites via the single-nucleotide replacement pathway ⁶⁶	12.44	MLH1 MSH2 MSH6 POLE
21	Development VEGF signaling via VEGFR2 - generic cascades ²² Show member pathways Development VEGF signaling and activation ²² VEGF - VEGF R2 Signaling Pathways ⁶⁵	12.42	PIK3CA KRAS HRAS CTNNB1
22	G-protein signaling RAC1 in cellular process ²² Show member pathways CDC42 signaling events ⁶¹ Cytoskeleton remodeling CDC42 in cellular processes ²² RAC1 signaling pathway ⁶¹	12.41	CTNNB1 ERBB2 HRAS KRAS PIK3CA
23	CD28 co-stimulation ⁶⁶ Show member pathways Activation of AKT2 ⁶⁶ CD28 dependent PI3K/Akt signaling ⁶⁶ CD28 dependent Vav1 pathway ⁶⁶ Costimulation by the CD28 family ⁶⁶ CTLA4 Signaling ⁶⁴ VEGFR2 mediated vascular permeability ⁶⁶	12.38	PPP2R1A PIK3CA ICOSLG CTNNB1 CD8A CD274
24	B Cell Receptor Signaling Pathway ⁶⁷ Show member pathways T Cell Receptor Signaling Pathway ⁶⁷	12.34	PTEN PIK3CA KRAS HRAS
25	Signaling by VEGF ⁶⁶ Show member pathways VEGFA-VEGFR2 Pathway ⁶⁶	12.34	PIK3CA KRAS HRAS CTNNB1
26	Focal adhesion ⁷⁴	12.32	PTEN PIK3CA HRAS ERBB2 CTNNB1
27	Breast cancer pathway ⁷⁴ Show member pathways Embryonic stem cell pluripotency pathways ⁷⁴	12.3	TP53 PTEN PIK3CA KRAS HRAS ERBB2
28	Signaling by FGFR2 ⁶⁶ Show member pathways FGFR2 ligand binding and activation ⁶⁶ FGFR2b ligand binding and activation ⁶⁶ Signaling by FGFR ⁶⁶	12.29	PPP2R1A PIK3CA KRAS HRAS
29	Development IGF-1 receptor signaling ²² Show member pathways Immune response IL-4 signaling pathway ²² Signal transduction AKT signaling ²²	12.28	TP53 PTEN PIK3CA HRAS
30	Signaling by ERBB2 KD Mutants ⁶⁶ Show member pathways Constitutive Signaling by Overexpressed ERBB2 ⁶⁶ GRB2 events in ERBB2 signaling ⁶⁶ PI3K events in ERBB2 signaling ⁶⁶ PI3K events in ERBB4 signaling ⁶⁶ PLCG1 events in ERBB2 signaling ⁶⁶ SHC1 events in ERBB2 signaling ⁶⁶ SHC1 events in ERBB4 signaling ⁶⁶ Signaling by ERBB2 ECD mutants ⁶⁶ Signaling by ERBB2 in Cancer ⁶⁶ Signaling by ERBB2 TMD/JMD mutants ⁶⁶	12.27	PIK3CA KRAS HRAS ERBB2
31	MAPK Signaling: Mitogens ⁶⁵ Show member pathways Akt Signaling Pathway ⁶⁵	12.25	ERBB2 HRAS KRAS PIK3CA PTEN TP53
32	Epithelial to mesenchymal transition in colorectal cancer ⁷⁴	12.22	CTNNB1 HRAS KRAS PIK3CA TP53
33	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	12.18	TP53 PTEN PIK3CA HRAS CD8A
34	Transcription Androgen Receptor nuclear signaling ²² Show member pathways Translation Non-genomic (rapid) action of Androgen Receptor ²²	12.16	PTEN PIK3CA HRAS ERBB2 CTNNB1
35	mTOR Signaling ⁶⁵	12.12	TP53 PTEN KRAS ERBB2
36	Signaling by ERBB4 ⁶⁶ Show member pathways Downregulation of ERBB4 signaling ⁶⁶ ErbB4 signaling events ⁶¹ Nuclear signaling by ERBB4 ⁶⁶	12.1	PIK3CA KRAS HRAS ERBB2
37	Colorectal Cancer Metastasis ⁶⁴	12.1	CTNNB1 KRAS MLH1 MSH2 MSH6 TP53
38	Direct p53 effectors ⁶¹	12.08	TP53 PTEN MSH2 MLH1
39	Signaling by ERBB2 ⁶⁶ Show member pathways Downregulation of ERBB2 signaling ⁶⁶ Downregulation of ERBB2:ERBB3 signaling ⁶⁶ ERBB2 Activates PTK6 Signaling ⁶⁶ ERBB2 Regulates Cell Motility ⁶⁶ GRB7 events in ERBB2 signaling ⁶⁶	12.06	PIK3CA KRAS HRAS ERBB2
40	Integrated breast cancer pathway ⁷⁴	12.02	TP53 PTEN MSH6 MSH2 KRAS CTNNB1
41	Gastrin signaling pathway ⁷⁴	12	PIK3CA KRAS HRAS CTNNB1
42	Development EGFR signaling via small GTPases ²² Show member pathways Development EGFR signaling via PIP3 ²² Development PDGF signaling via MAPK cascades ²²	11.98	ERBB2 HRAS KRAS PIK3CA PTEN
43	FGFR1 mutant receptor activation ⁶⁶ Show member pathways Signaling by cytosolic FGFR1 fusion mutants ⁶⁶ Signaling by FGFR1 in disease ⁶⁶ Signaling by plasma membrane FGFR1 fusions ⁶⁶	11.88	PIK3CA KRAS HRAS
44	Signaling by PDGF ⁶⁶ Show member pathways Downstream signal transduction ⁶⁶	11.86	PIK3CA KRAS HRAS
45	Thyroid hormones production and peripheral downstream signaling effects ⁷⁴	11.86	TP53 PIK3CA HRAS CTNNB1
46	Retinoblastoma gene in cancer ⁷⁴	11.85	TP53 POLE MSH6
47	BRCA1 Pathway ⁶⁴ Show member pathways Fanconi's Anaemia Pathway ⁶⁴	11.84	TP53 MSH6 MSH2
48	mTOR Pathway ⁷⁰ Show member pathways TGF-beta Pathway ⁷⁰	11.84	TP53 PIK3CA KRAS HRAS
49	DNA IR-damage and cellular response via ATR ⁷⁴	11.82	TP53 MSH2 MLH1
50	VEGF Pathway (Tocris) ⁷⁰ Show member pathways Sorafenib Pharmacodynamics ⁶⁰	11.81	PIK3CA KRAS HRAS

Sources

GO Terms for Uterine Body Mixed Cancer

Cellular components related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chromosome	GO:0005694	9.56	PPP2R1A MSH6 MSH2 MLH1 H2AC18 FBXW7
2	MutSalpha complex	GO:0032301	8.92	MSH6 MSH2

Biological processes related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

(show all 15)

#	Name	GO ID	Score	Top Affiliating Genes
1	T cell receptor signaling pathway	GO:0050852	10.06	PIK3CA ICOSLG HRAS CD8A
2	phosphatidylinositol 3-kinase signaling	GO:0014065	10.01	PTEN PIK3CA ERBB2
3	cellular response to DNA damage stimulus	GO:0006974	9.98	FBXW7 MLH1 MSH2 MSH6 POLE TP53
4	intrinsic apoptotic signaling pathway	GO:0097193	9.95	TP53 MSH6 HRAS
5	embryonic organ development	GO:0048568	9.92	TP53 POLE CTNNB1
6	mismatch repair	GO:0006298	9.88	MSH6 MSH2 MLH1
7	positive regulation of helicase activity	GO:0051096	9.85	MSH6 MSH2
8	positive regulation of isotype switching to IgA isotypes	GO:0048298	9.81	MSH2 MLH1
9	determination of adult lifespan	GO:0008340	9.8	MSH2 MSH6 TP53
10	vasculature development	GO:0001944	9.77	PIK3CA FBXW7 CTNNB1
11	isotype switching	GO:0045190	9.73	MSH6 MSH2 MLH1
12	maintenance of DNA repeat elements	GO:0043570	9.67	MSH6 MSH2
13	somatic hypermutation of immunoglobulin genes	GO:0016446	9.43	MSH6 MSH2 MLH1
14	somatic recombination of immunoglobulin genes involved in immune response	GO:0002204	9.33	MSH2 MLH1
15	somatic recombination of immunoglobulin gene segments	GO:0016447	9.02	MSH6 MSH2 MLH1

Molecular functions related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chromatin binding	GO:0003682	10.21	TP53 POLE MSH6 MSH2 MLH1 CTNNB1
2	enzyme binding	GO:0019899	10.15	CTNNB1 MLH1 MSH2 MSH6 PTEN TP53
3	nucleotide binding	GO:0000166	10.06	POLE PIK3CA MSH6 MSH2 MLH1 KRAS
4	ATP-dependent DNA damage sensor activity	GO:0140664	9.63	MSH6 MSH2 MLH1
5	single guanine insertion binding	GO:0032142	9.62	MSH6 MSH2
6	single thymine insertion binding	GO:0032143	9.56	MSH6 MSH2
7	mismatched DNA binding	GO:0030983	9.35	MSH6 MSH2 MLH1
8	guanine/thymine mispair binding	GO:0032137	9.1	MSH6 MSH2 MLH1

Sources

Sources for Uterine Body Mixed Cancer

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: UTR032 MIFTS: 30	Uterine Body Mixed Cancer Categories: Cancer diseases, Reproductive diseases	Data Licensing For inquiries, contact: [email protected]
Genes Related diseases Expand all tables