Uterine Body Mixed Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: UTR032 MIFTS: 34	Uterine Body Mixed Cancer Categories: Cancer diseases, Reproductive diseases
Genes Tissues Related diseases Pathways Expand all tables

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Aliases & Classifications for Uterine Body Mixed Cancer

MalaCards integrated aliases for Uterine Body Mixed Cancer:

Name: Uterine Body Mixed Cancer ¹² ¹⁵

Malignant Mixed Tumor, Not Otherwise Specified ⁷³

Malignant Mixed Tumor of Corpus Uteri ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4114

NCIt ⁵⁰ C6311

UMLS ⁷³ C1334628 C4054577

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Summaries for Uterine Body Mixed Cancer

Disease Ontology : ¹² A uterine corpus cancer that has material basis in more than one type of cell.

MalaCards based summary : Uterine Body Mixed Cancer, also known as malignant mixed tumor, not otherwise specified, is related to uterine carcinosarcoma and uterine corpus adenocarcinofibroma. An important gene associated with Uterine Body Mixed Cancer is PIK3R2 (Phosphoinositide-3-Kinase Regulatory Subunit 2), and among its related pathways/superpathways are Developmental Biology and Class I MHC mediated antigen processing and presentation. Affiliated tissues include lung, brain and bone, and related phenotypes are Decreased homologous recombination repair frequency and Decreased homologous recombination repair frequency

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Related Diseases for Uterine Body Mixed Cancer

Diseases related to Uterine Body Mixed Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)

#	Related Disease	Score	Top Affiliating Genes
1	uterine carcinosarcoma	30.6	ERBB2 FBXW7 PGR PIK3CA PIK3R2 PPP2R1A
2	uterine corpus adenocarcinofibroma	11.2
3	endometrioid ovary carcinoma	10.2	ARID1A PPP2R1A
4	prostate squamous cell carcinoma	10.1	PPP2R1A TP53
5	cutis marmorata telangiectatica congenita	10.1	PIK3CA PIK3R2
6	megalencephaly-capillary malformation-polymicrogyria syndrome	10.1	PIK3CA PIK3R2
7	epithelial-myoepithelial carcinoma	10.1	FBXW7 TP53
8	gastric papillary adenocarcinoma	10.1	ERBB2 TP53
9	pleomorphic adenoma carcinoma	10.1	ERBB2 TP53
10	non-proliferative fibrocystic change of the breast	10.1	ERBB2 TP53
11	glioma susceptibility 1	10.1	ERBB2 TP53
12	esophagus adenocarcinoma	10.0	ERBB2 TP53
13	adult hepatocellular carcinoma	10.0	PIK3CA TP53
14	rare adenocarcinoma of the breast	10.0	PIK3CA TP53
15	malignant spiradenoma	10.0	PIK3CA TP53
16	clear cell adenofibroma	10.0	ARID1A PIK3CA
17	proteus syndrome	10.0	PIK3CA PIK3R2
18	ovarian clear cell adenocarcinoma	10.0	ARID1A PIK3CA
19	granulosa cell tumor of the ovary	10.0	ERBB2 TP53
20	hidradenocarcinoma	10.0	ERBB2 TP53
21	acneiform dermatitis	10.0	ERBB2 PIK3CA
22	congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	10.0	PIK3CA PIK3R2
23	tonsil cancer	10.0	ERBB2 TP53
24	barrett's adenocarcinoma	10.0	ERBB2 TP53
25	endometrium carcinoma in situ	10.0	PGR TP53
26	scirrhous adenocarcinoma	10.0	ERBB2 PGR
27	breast apocrine carcinoma	10.0	ERBB2 PGR
28	glassy cell carcinoma of the cervix	10.0	ERBB2 PGR
29	intracystic papillary adenoma	10.0	ERBB2 PGR
30	breast metaplastic carcinoma	10.0	ERBB2 PGR
31	adenosquamous lung carcinoma	10.0	ERBB2 PIK3CA
32	progesterone-receptor negative breast cancer	10.0	ERBB2 PGR
33	breast medullary carcinoma	10.0	ERBB2 PGR
34	breast scirrhous carcinoma	10.0	ERBB2 PGR
35	breast malignant phyllodes tumor	10.0	PGR TP53
36	progesterone-receptor positive breast cancer	10.0	ERBB2 PGR
37	olfactory groove meningioma	10.0	PGR TP53
38	breast adenoid cystic carcinoma	10.0	ERBB2 PGR
39	apocrine adenocarcinoma	10.0	ERBB2 PGR
40	synchronous bilateral breast carcinoma	10.0	PGR TP53
41	endometriosis of ovary	9.9	ARID1A PGR
42	papillary serous adenocarcinoma	9.9	PGR TP53
43	bartholin's gland disease	9.9	PGR TP53
44	female reproductive endometrioid cancer	9.9	PGR TP53
45	cervical carcinosarcoma	9.9	PGR TP53
46	glycogen-rich clear cell breast carcinoma	9.9	PGR TP53
47	anterior cranial fossa meningioma	9.9	PGR TP53
48	inflammatory breast carcinoma	9.9	ERBB2 PGR
49	adenosarcoma	9.9	PGR TP53
50	luminal breast carcinoma	9.9	ERBB2 PGR

Graphical network of the top 20 diseases related to Uterine Body Mixed Cancer:

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Symptoms & Phenotypes for Uterine Body Mixed Cancer

GenomeRNAi Phenotypes related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased homologous recombination repair frequency	GR00236-A-1	9.56	ARID1A PGR PPP2R1A
2	Decreased homologous recombination repair frequency	GR00236-A-2	9.56	ARID1A PGR PIK3R2 PPP2R1A
3	Decreased homologous recombination repair frequency	GR00236-A-3	9.56	PIK3R2
4	Decreased CDKN1A mRNA expression	GR00389-S-1	9.33	FBXW7 TP53
5	Decreased CDKN1A mRNA expression	GR00389-S-2	9.33	TP53
6	Increased cell death HMECs cells	GR00103-A-0	9.02	FBXW7 PGR PIK3CA PPP2R1A TP53

MGI Mouse Phenotypes related to Uterine Body Mixed Cancer:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.02	ARID1A ERBB2 FBXW7 PGR PIK3CA PIK3R2
2	cellular	MP:0005384	10	ARID1A ERBB2 FBXW7 PGR PIK3CA PKP3
3	growth/size/body region	MP:0005378	9.97	ARID1A ERBB2 FBXW7 PIK3CA PIK3R2 PKP3
4	homeostasis/metabolism	MP:0005376	9.92	ARID1A ERBB2 FBXW7 PGR PIK3CA PIK3R2
5	embryo	MP:0005380	9.91	ARID1A ERBB2 FBXW7 PGR PIK3CA TP53
6	endocrine/exocrine gland	MP:0005379	9.88	ARID1A ERBB2 FBXW7 PGR PIK3CA TP53
7	integument	MP:0010771	9.73	ERBB2 FBXW7 PGR PIK3CA PKP3 TP53
8	muscle	MP:0005369	9.63	ARID1A ERBB2 PGR PIK3CA PIK3R2 TP53
9	neoplasm	MP:0002006	9.56	ARID1A ERBB2 FBXW7 PGR PIK3CA PIK3R2
10	normal	MP:0002873	9.17	ARID1A ERBB2 FBXW7 PGR PKP3 PPP2R1A

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Drugs & Therapeutics for Uterine Body Mixed Cancer

Search Clinical Trials , NIH Clinical Center for Uterine Body Mixed Cancer

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Genetic Tests for Uterine Body Mixed Cancer

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Anatomical Context for Uterine Body Mixed Cancer

MalaCards organs/tissues related to Uterine Body Mixed Cancer:

⁴¹

Lung, Brain, Bone, Ovary, Pancreas, Cervix, Thyroid

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Publications for Uterine Body Mixed Cancer

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Genes for Uterine Body Mixed Cancer

Genes related to Uterine Body Mixed Cancer (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	18.5	DISEASES inferred ¹⁵ ¹⁵
2	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	14.9	DISEASES inferred ¹⁵
3	FBXW7	F-Box And WD Repeat Domain Containing 7	Protein Coding	14.72	DISEASES inferred ¹⁵
4	PKP3	Plakophilin 3	Protein Coding	14.69	DISEASES inferred ¹⁵
5	ARID1A	AT-Rich Interaction Domain 1A	Protein Coding	14.65	DISEASES inferred ¹⁵
6	TP53	Tumor Protein P53	Protein Coding	14.64	DISEASES inferred ¹⁵
7	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	14.56	DISEASES inferred ¹⁵
8	PGR	Progesterone Receptor	Protein Coding	14.5	DISEASES inferred ¹⁵
9	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	14.46	DISEASES inferred ¹⁵

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Variations for Uterine Body Mixed Cancer

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Expression for Uterine Body Mixed Cancer

Search GEO for disease gene expression data for Uterine Body Mixed Cancer.

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Pathways for Uterine Body Mixed Cancer

Pathways related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 57)

#	Super pathways	Score	Top Affiliating Genes
1	Developmental Biology ⁶⁶ Show member pathways Axon guidance ⁶⁶	13.33	ERBB2 PIK3CA PIK3R2 PKP3 PPP2R1A
2	Class I MHC mediated antigen processing and presentation ⁶⁶ Show member pathways Adaptive Immune System ⁶⁶ Antigen processing- Ubiquitination and Proteasome degradation ⁶⁶	13.25	ERBB2 FBXW7 PIK3CA PIK3R2 PPP2R1A TP53
3	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.2	ERBB2 PIK3CA PIK3R2 PPP2R1A TP53
4	PI3K/AKT activation ⁶⁶ Show member pathways Constitutive Signaling by Aberrant PI3K in Cancer ⁶⁶ GAB1 signalosome ⁶⁶ Negative regulation of the PI3K/AKT network ⁶⁶ PI3K/AKT Signaling in Cancer ⁶⁶ PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ⁶⁶ PIP3 activates AKT signaling ⁶⁶ Role of LAT2/NTAL/LAB on calcium mobilization ⁶⁶	12.95	ERBB2 PIK3CA PIK3R2 PPP2R1A TP53
5	Circadian entrainment ³⁷ Show member pathways Cholinergic synapse ³⁷ Dopaminergic synapse ³⁷ Estrogen signaling pathway ³⁷ Glutamatergic synapse ³⁷ Relaxin receptors ⁶⁶ Relaxin signaling pathway ³⁷ Synaptic Neurotransmission Pathways: Glutamatergic Excitation ⁶⁵	12.88	PGR PIK3CA PIK3R2 PPP2R1A
6	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	12.8	ERBB2 PIK3CA PIK3R2 PPP2R1A TP53
7	Endometrial cancer ³⁷ Show member pathways Acute myeloid leukemia ³⁷ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁶ Chronic myeloid leukemia ³⁷ Colorectal cancer ³⁷ Pancreatic cancer ³⁷ Prostate cancer ³⁷ Signal transduction PTEN pathway ²² Thyroid cancer ³⁷	12.73	ERBB2 PIK3CA PIK3R2 TP53
8	Pathways in cancer ³⁷	12.7	ERBB2 PIK3CA PIK3R2 TP53
9	Glioma ³⁷ Show member pathways EGFR tyrosine kinase inhibitor resistance ³⁷ Endocrine resistance ³⁷ Melanoma ³⁷ Non-small cell lung cancer ³⁷ Signaling Pathways in Glioblastoma ¹	12.62	ERBB2 PIK3CA PIK3R2 TP53
10	Development HGF signaling pathway ²² Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²² Apoptosis and survival NGF signaling pathway ²² Apoptosis and survival Role of CDK5 in neuronal death and survival ²² Development Neurotrophin family signaling ²² MET activates PTPN11 ⁶⁶ MET activates STAT3 ⁶⁶ Neurotrophin signaling pathway ³⁷ Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) ¹ Signaling of Hepatocyte Growth Factor Receptor ¹	12.58	ERBB2 PIK3CA PIK3R2 TP53
11	Downstream signaling events of B Cell Receptor (BCR) ⁶⁶ Show member pathways Activation of RAS in B cells ⁶⁶ Signaling by the B Cell Receptor (BCR) ⁶⁶	12.49	ERBB2 PIK3CA PIK3R2 PPP2R1A TP53
12	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²² Rac1/Pak1/p38/MMP-2 pathway ¹	12.44	ERBB2 PIK3CA PIK3R2 TP53
13	Development EGFR signaling pathway ²² Show member pathways Development ERBB-family signaling ²² EGF Pathway ⁶⁴ EGFR Signaling Pathway ⁶⁷ ErbB receptor signaling network ¹	12.39	ERBB2 PIK3CA PIK3R2 TP53
14	MicroRNAs in cancer ³⁷	12.37	ERBB2 PIK3CA PIK3R2 TP53
15	mTOR signaling pathway (KEGG) ⁶⁵ Show member pathways mTOR signaling pathway ³⁷	12.35	ERBB2 PIK3CA PIK3R2 TP53
16	ErbB signaling pathway ¹ ³⁷ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶¹ Renal cell carcinoma ³⁷ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.32	ERBB2 PIK3CA PIK3R2 TP53
17	Human T-cell leukemia virus 1 infection ³⁷	12.3	PIK3CA PIK3R2 TP53
18	Development IGF-1 receptor signaling ²² Show member pathways IL-4 Signaling Pathway ¹ Immune response IL-4 signaling pathway ²² Signal transduction AKT signaling ²²	12.27	PIK3CA PIK3R2 TP53
19	AMP-activated Protein Kinase (AMPK) Signaling ¹ Show member pathways AMPK signaling pathway ³⁷ AMPK Signaling Pathway ⁶⁷	12.25	PIK3CA PIK3R2 PPP2R1A TP53
20	Apoptosis Pathway ⁷² Show member pathways Akt Pathway ⁷² NF-kappaB Pathway ⁷²	12.25	ERBB2 PIK3CA PIK3R2 TP53
21	Development Ligand-independent activation of ESR1 and ESR2 ²² Show member pathways Transcription CREB pathway ²² Transcription PPAR Pathway ²²	12.2	ERBB2 PIK3CA PIK3R2
22	Toll Comparative Pathway ⁶⁴ Show member pathways IL-1 Pathway ⁶⁴ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶⁴ TLR-TRIF Pathway ⁶⁴	12.18	PIK3CA PIK3R2 TP53
23	Epstein-Barr virus infection ³⁷	12.18	PIK3CA PIK3R2 TP53
24	Viral carcinogenesis ³⁷	12.17	PIK3CA PIK3R2 TP53
25	Oocyte meiosis ³⁷ Show member pathways Progesterone-mediated oocyte maturation ³⁷	12.16	PGR PIK3CA PIK3R2 PPP2R1A
26	Proteoglycans in cancer ³⁷	12.1	ERBB2 PIK3CA PIK3R2 TP53
27	Gastric cancer ³⁷ Show member pathways Breast cancer ³⁷ Hepatocellular carcinoma ³⁷	12.1	ARID1A ERBB2 PGR PIK3CA PIK3R2 TP53
28	CD28 co-stimulation ⁶⁶ Show member pathways Activation of AKT2 ⁶⁶ CD28 dependent PI3K/Akt signaling ⁶⁶ CD28 dependent Vav1 pathway ⁶⁶ Costimulation by the CD28 family ⁶⁶ VEGFR2 mediated vascular permeability ⁶⁶	12.09	PIK3CA PIK3R2 PPP2R1A
29	Cellular senescence (KEGG) ³⁷	12.05	PIK3CA PIK3R2 TP53
30	mTOR Pathway ⁷² Show member pathways Insulin Pathway ⁷² TGF-beta Pathway ⁷²	12.05	PIK3CA PIK3R2 TP53
31	MAPK Signaling: Mitogen Stimulation Pathway ⁶⁵ Show member pathways Akt Signaling Pathway ⁶⁵	12.03	ERBB2 PIK3CA PIK3R2 TP53
32	Development EGFR signaling via small GTPases ²² Show member pathways Development EGFR signaling via PIP3 ²² Development PDGF signaling via MAPK cascades ²² PDGF Pathway ¹	12.02	ERBB2 PIK3CA PIK3R2
33	Longevity regulating pathway ³⁷ Show member pathways Longevity regulating pathway - multiple species ³⁷	12.01	PIK3CA PIK3R2 TP53
34	Fluid shear stress and atherosclerosis ³⁷	11.97	PIK3CA PIK3R2 TP53
35	AKT Signaling Pathway ⁶⁷	11.93	ERBB2 PIK3CA PIK3R2 TP53
36	Thyroid hormone signaling pathway ³⁷	11.88	PIK3CA PIK3R2 TP53
37	Hepatitis C ³⁷	11.85	PIK3CA PIK3R2 PPP2R1A TP53
38	Signaling by ERBB4 ⁶⁶ Show member pathways Downregulation of ERBB4 signaling ⁶⁶ ErbB4 signaling events ¹ Nuclear signaling by ERBB4 ⁶⁶	11.84	ERBB2 PGR PIK3CA
39	HIF-1 signaling pathway ³⁷	11.8	ERBB2 PIK3CA PIK3R2
40	MAPK Pathway ⁷² Show member pathways Toll-like Receptor Pathway ⁷²	11.8	ERBB2 PIK3CA PIK3R2 TP53
41	Small cell lung cancer ³⁷	11.76	PIK3CA PIK3R2 TP53
42	Sphingolipid signaling pathway ³⁷	11.74	PIK3CA PIK3R2 PPP2R1A TP53
43	DNA Damage Response (only ATM dependent) ¹	11.68	ERBB2 PIK3CA PIK3R2 TP53
44	Bladder cancer ³⁷ ¹	11.62	ERBB2 PIK3R2 TP53
45	IL-2 Gene Expression in Activated and Quiescent T-Cells ⁶⁴ Show member pathways TOB in T-Cell Signaling ⁶⁴	11.51	ERBB2 PIK3CA PIK3R2
46	Platinum drug resistance ³⁷	11.42	ERBB2 PIK3CA PIK3R2 TP53
47	G13 Signaling Pathway ¹	11.33	PIK3CA PIK3R2
48	Aldosterone-regulated sodium reabsorption ³⁷	11.28	PIK3CA PIK3R2
49	G-protein signaling_Cross-talk between Ras-family GTPases ²²	11.27	ERBB2 PIK3CA PIK3R2
50	Central carbon metabolism in cancer ³⁷	11.27	ERBB2 PIK3CA PIK3R2 TP53

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GO Terms for Uterine Body Mixed Cancer

Cellular components related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	phosphatidylinositol 3-kinase complex	GO:0005942	8.62	PIK3CA PIK3R2

Biological processes related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of protein kinase B signaling	GO:0051897	9.33	ERBB2 PIK3CA PIK3R2
2	ERBB2 signaling pathway	GO:0038128	9.32	ERBB2 PIK3CA
3	vasculature development	GO:0001944	9.26	FBXW7 PIK3CA
4	phosphatidylinositol phosphorylation	GO:0046854	9.13	ERBB2 PIK3CA PIK3R2
5	phosphatidylinositol 3-kinase signaling	GO:0014065	8.8	ERBB2 PIK3CA PIK3R2

Molecular functions related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein heterodimerization activity	GO:0046982	9.46	ERBB2 PIK3R2 PPP2R1A TP53
2	protein phosphatase binding	GO:0019903	9.13	ERBB2 PIK3R2 TP53
3	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO:0046934	8.8	ERBB2 PIK3CA PIK3R2

Sources

Sources for Uterine Body Mixed Cancer

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia