MCID: UTR032
MIFTS: 31

Uterine Body Mixed Cancer

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Uterine Body Mixed Cancer

MalaCards integrated aliases for Uterine Body Mixed Cancer:

Name: Uterine Body Mixed Cancer 12 15
Malignant Mixed Tumor, Not Otherwise Specified 73
Malignant Mixed Tumor of Corpus Uteri 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4114
NCIt 50 C6311

Summaries for Uterine Body Mixed Cancer

Disease Ontology : 12 A uterine corpus cancer that has material basis in more than one type of cell.

MalaCards based summary : Uterine Body Mixed Cancer, also known as malignant mixed tumor, not otherwise specified, is related to uterine carcinosarcoma and endometrioid ovary carcinoma. An important gene associated with Uterine Body Mixed Cancer is PIK3R2 (Phosphoinositide-3-Kinase Regulatory Subunit 2), and among its related pathways/superpathways are Gene Expression and GPCR Pathway. Related phenotypes are Decreased homologous recombination repair frequency and Decreased homologous recombination repair frequency

Related Diseases for Uterine Body Mixed Cancer

Diseases related to Uterine Body Mixed Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 uterine carcinosarcoma 27.6 ERBB2 ESR2 KIT PGR PIK3R2 PPP2R1A
2 endometrioid ovary carcinoma 10.5 ARID1A PPP2R1A
3 prostate squamous cell carcinoma 10.5 PPP2R1A TP53
4 endometrium carcinoma in situ 10.4 PGR TP53
5 vestibular gland benign neoplasm 10.4 PGR TP53
6 bartholin's gland adenoma 10.4 PGR TP53
7 female reproductive endometrioid cancer 10.4 PGR TP53
8 breast malignant phyllodes tumor 10.4 PGR TP53
9 olfactory groove meningioma 10.4 PGR TP53
10 sarcomatoid squamous cell skin carcinoma 10.4 KIT TP53
11 bartholin's gland benign neoplasm 10.4 PGR TP53
12 synchronous bilateral breast carcinoma 10.4 PGR TP53
13 papillary serous adenocarcinoma 10.4 PGR TP53
14 cervical carcinosarcoma 10.3 PGR TP53
15 anterior cranial fossa meningioma 10.3 PGR TP53
16 glycogen-rich clear cell breast carcinoma 10.3 PGR TP53
17 pleomorphic carcinoma 10.3 KIT TP53
18 gallbladder squamous cell carcinoma 10.3 ERBB2 TP53
19 gastric papillary adenocarcinoma 10.3 ERBB2 TP53
20 uterine corpus serous adenocarcinoma 10.3 ERBB2 TP53
21 non-proliferative fibrocystic change of the breast 10.3 ERBB2 TP53
22 cribriform carcinoma 10.3 KIT PGR
23 necrotizing sialometaplasia 10.3 KIT TP53
24 malignant mixed mullerian tumor 10.3 KIT PGR
25 benign breast phyllodes tumor 10.2 KIT PGR
26 pleomorphic adenoma carcinoma 10.2 ERBB2 TP53
27 adenoid basal cell carcinoma 10.2 KIT PGR
28 embryonal sarcoma 10.2 KIT TP53
29 fallopian tube adenocarcinoma 10.2 ERBB2 TP53
30 breast angiosarcoma 10.2 KIT PGR
31 glioma susceptibility 1 10.2 ERBB2 TP53
32 cystic nephroma 10.2 KIT PGR
33 oral leukoplakia 10.2 ERBB2 TP53
34 scirrhous adenocarcinoma 10.2 ERBB2 PGR
35 breast apocrine carcinoma 10.2 ERBB2 PGR
36 perivascular epithelioid cell tumor 10.2 KIT PGR
37 papillary hidradenoma 10.2 KIT PGR
38 esophagus adenocarcinoma 10.2 ERBB2 TP53
39 glassy cell carcinoma of the cervix 10.2 ERBB2 PGR
40 breast mucoepidermoid carcinoma 10.2 ERBB2 PGR
41 breast metaplastic carcinoma 10.2 ERBB2 PGR
42 intracystic papillary adenoma 10.2 ERBB2 PGR
43 progesterone-receptor negative breast cancer 10.2 ERBB2 PGR
44 breast medullary carcinoma 10.2 ERBB2 PGR
45 breast scirrhous carcinoma 10.2 ERBB2 PGR
46 dermoid cyst 10.1 KIT PGR
47 oncocytic breast carcinoma 10.1 ERBB2 PGR
48 apocrine adenocarcinoma 10.1 ERBB2 PGR
49 smooth muscle tumor 10.1 KIT PGR
50 granulosa cell tumor of the ovary 10.1 ERBB2 TP53

Graphical network of the top 20 diseases related to Uterine Body Mixed Cancer:



Diseases related to Uterine Body Mixed Cancer

Symptoms & Phenotypes for Uterine Body Mixed Cancer

GenomeRNAi Phenotypes related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased homologous recombination repair frequency GR00236-A-1 9.56 ARID1A PGR PPP2R1A
2 Decreased homologous recombination repair frequency GR00236-A-2 9.56 ARID1A PGR PIK3R2 PPP2R1A
3 Decreased homologous recombination repair frequency GR00236-A-3 9.56 PIK3R2
4 Increased TP53 mRNA expression GR00389-S-6 8.62 ESR2 TP53

MGI Mouse Phenotypes related to Uterine Body Mixed Cancer:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.08 ESR2 ARID1A KIT ERBB2 PIK3R2 PKP3
2 cardiovascular system MP:0005385 10.07 ERBB2 PGR ESR2 ARID1A KIT PIK3R2
3 homeostasis/metabolism MP:0005376 10.06 ERBB2 PGR ESR2 ARID1A KIT PIK3R2
4 cellular MP:0005384 10.05 KIT ERBB2 ESR2 ARID1A PKP3 TP53
5 endocrine/exocrine gland MP:0005379 9.97 KIT ERBB2 ESR2 ARID1A TP53 PGR
6 neoplasm MP:0002006 9.92 PGR ESR2 ARID1A KIT ERBB2 PIK3R2
7 integument MP:0010771 9.91 ERBB2 PGR ESR2 KIT PKP3 TP53
8 muscle MP:0005369 9.91 PGR ESR2 ARID1A KIT ERBB2 PIK3R2
9 limbs/digits/tail MP:0005371 9.8 KIT ERBB2 PGR ESR2 TP53
10 normal MP:0002873 9.76 PGR ESR2 ARID1A KIT ERBB2 PKP3
11 no phenotypic analysis MP:0003012 9.65 KIT ESR2 ARID1A PGR TP53
12 reproductive system MP:0005389 9.43 KIT ERBB2 ESR2 ARID1A TP53 PGR
13 skeleton MP:0005390 9.1 KIT ERBB2 ESR2 ARID1A TP53 PGR

Drugs & Therapeutics for Uterine Body Mixed Cancer

Search Clinical Trials , NIH Clinical Center for Uterine Body Mixed Cancer

Genetic Tests for Uterine Body Mixed Cancer

Anatomical Context for Uterine Body Mixed Cancer

Publications for Uterine Body Mixed Cancer

Variations for Uterine Body Mixed Cancer

Expression for Uterine Body Mixed Cancer

Search GEO for disease gene expression data for Uterine Body Mixed Cancer.

Pathways for Uterine Body Mixed Cancer

Pathways related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.57 ERBB2 ESR2 KIT PGR PPP2R1A TP53
2
Show member pathways
13.45 ERBB2 ESR2 KIT PIK3R2 PPP2R1A TP53
3
Show member pathways
13.39 ARID1A ERBB2 KIT PIK3R2 PPP2R1A TP53
4
Show member pathways
13.27 ERBB2 KIT PIK3R2 PPP2R1A TP53
5
Show member pathways
13.21 ERBB2 KIT PIK3R2 PPP2R1A TP53
6
Show member pathways
13.16 ERBB2 KIT PIK3R2 PPP2R1A TP53
7
Show member pathways
13.09 ERBB2 KIT PIK3R2 PPP2R1A TP53
8
Show member pathways
12.99 ERBB2 ESR2 KIT PIK3R2 PPP2R1A
9
Show member pathways
12.81 ESR2 PGR PIK3R2 PPP2R1A
10
Show member pathways
12.79 ERBB2 KIT PIK3R2 PPP2R1A TP53
11
Show member pathways
12.61 ERBB2 KIT PIK3R2 TP53
12
Show member pathways
12.59 ERBB2 KIT PIK3R2 PPP2R1A TP53
13
Show member pathways
12.51 ERBB2 ESR2 PIK3R2 TP53
14 12.38 ERBB2 ESR2 KIT PIK3R2 TP53
15
Show member pathways
12.25 ERBB2 PIK3R2 TP53
16
Show member pathways
12.24 PIK3R2 PPP2R1A TP53
17
Show member pathways
12.19 ERBB2 KIT PIK3R2 PPP2R1A TP53
18
Show member pathways
12.15 PGR PIK3R2 PPP2R1A
19
Show member pathways
12.11 ERBB2 ESR2 PIK3R2
20 12.07 ERBB2 PIK3R2 TP53
21 11.94 ERBB2 PIK3R2 TP53
22
Show member pathways
11.83 ARID1A ERBB2 ESR2 KIT PGR PIK3R2
23 11.82 PIK3R2 PPP2R1A TP53
24
Show member pathways
11.78 ERBB2 PIK3R2 TP53
25 11.74 PIK3R2 PPP2R1A TP53
26 11.71 ERBB2 PIK3R2 TP53
27 11.47 ERBB2 PIK3R2 TP53
28 11.44 ERBB2 PIK3R2 TP53
29 11.32 ARID1A ERBB2 TP53
30 11.13 ESR2 PGR
31 11.07 ERBB2 KIT PIK3R2 TP53
32 10.9 PIK3R2 TP53

GO Terms for Uterine Body Mixed Cancer

Biological processes related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.88 ARID1A ERBB2 ESR2 PGR PPP2R1A TP53
2 positive regulation of protein kinase B signaling GO:0051897 9.43 ERBB2 KIT PIK3R2
3 phosphatidylinositol 3-kinase signaling GO:0014065 9.37 ERBB2 PIK3R2
4 negative regulation of cell growth GO:0030308 9.33 ESR2 PPP2R1A TP53
5 intracellular estrogen receptor signaling pathway GO:0030520 9.32 ARID1A ESR2
6 positive regulation of gene expression GO:0010628 9.26 ERBB2 KIT PKP3 TP53
7 phosphatidylinositol phosphorylation GO:0046854 8.8 ERBB2 KIT PIK3R2

Molecular functions related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.62 ERBB2 PIK3R2 PPP2R1A TP53
2 binding GO:0005488 9.58 ARID1A PKP3 PPP2R1A
3 enzyme binding GO:0019899 9.46 ESR2 PGR PKP3 TP53
4 steroid binding GO:0005496 9.37 ESR2 PGR
5 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.26 ERBB2 KIT
6 protein phosphatase binding GO:0019903 9.13 ERBB2 PIK3R2 TP53
7 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.8 ERBB2 KIT PIK3R2

Sources for Uterine Body Mixed Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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