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MCID: UTR032
MIFTS: 31

Uterine Body Mixed Cancer

Categories: Cancer diseases, Reproductive diseases
Genes Related diseases Pathways
Sources

Aliases & Classifications for Uterine Body Mixed Cancer

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MalaCards integrated aliases for Uterine Body Mixed Cancer:

Name: Uterine Body Mixed Cancer 12 15
Malignant Mixed Tumor, Not Otherwise Specified 73
Malignant Mixed Tumor of Corpus Uteri 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4114
NCIt 50 C6311
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Summaries for Uterine Body Mixed Cancer

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Disease Ontology : 12 A uterine corpus cancer that has material basis in more than one type of cell.

MalaCards based summary : Uterine Body Mixed Cancer, also known as malignant mixed tumor, not otherwise specified, is related to uterine carcinosarcoma and endometrioid ovary carcinoma. An important gene associated with Uterine Body Mixed Cancer is PIK3R2 (Phosphoinositide-3-Kinase Regulatory Subunit 2), and among its related pathways/superpathways are Gene Expression and GPCR Pathway. Related phenotypes are Decreased homologous recombination repair frequency and Decreased homologous recombination repair frequency

Sources

Related Diseases for Uterine Body Mixed Cancer

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Diseases related to Uterine Body Mixed Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 uterine carcinosarcoma 27.6 ERBB2 ESR2 KIT PGR PIK3R2 PPP2R1A
2 endometrioid ovary carcinoma 10.5 ARID1A PPP2R1A
3 prostate squamous cell carcinoma 10.5 PPP2R1A TP53
4 endometrium carcinoma in situ 10.4 PGR TP53
5 vestibular gland benign neoplasm 10.4 PGR TP53
6 bartholin's gland adenoma 10.4 PGR TP53
7 female reproductive endometrioid cancer 10.4 PGR TP53
8 breast malignant phyllodes tumor 10.4 PGR TP53
9 olfactory groove meningioma 10.4 PGR TP53
10 sarcomatoid squamous cell skin carcinoma 10.4 KIT TP53
11 bartholin's gland benign neoplasm 10.4 PGR TP53
12 synchronous bilateral breast carcinoma 10.4 PGR TP53
13 papillary serous adenocarcinoma 10.4 PGR TP53
14 cervical carcinosarcoma 10.3 PGR TP53
15 anterior cranial fossa meningioma 10.3 PGR TP53
16 glycogen-rich clear cell breast carcinoma 10.3 PGR TP53
17 pleomorphic carcinoma 10.3 KIT TP53
18 gallbladder squamous cell carcinoma 10.3 ERBB2 TP53
19 gastric papillary adenocarcinoma 10.3 ERBB2 TP53
20 uterine corpus serous adenocarcinoma 10.3 ERBB2 TP53
21 non-proliferative fibrocystic change of the breast 10.3 ERBB2 TP53
22 cribriform carcinoma 10.3 KIT PGR
23 necrotizing sialometaplasia 10.3 KIT TP53
24 malignant mixed mullerian tumor 10.3 KIT PGR
25 benign breast phyllodes tumor 10.2 KIT PGR
26 pleomorphic adenoma carcinoma 10.2 ERBB2 TP53
27 adenoid basal cell carcinoma 10.2 KIT PGR
28 embryonal sarcoma 10.2 KIT TP53
29 fallopian tube adenocarcinoma 10.2 ERBB2 TP53
30 breast angiosarcoma 10.2 KIT PGR
31 glioma susceptibility 1 10.2 ERBB2 TP53
32 cystic nephroma 10.2 KIT PGR
33 oral leukoplakia 10.2 ERBB2 TP53
34 scirrhous adenocarcinoma 10.2 ERBB2 PGR
35 breast apocrine carcinoma 10.2 ERBB2 PGR
36 perivascular epithelioid cell tumor 10.2 KIT PGR
37 papillary hidradenoma 10.2 KIT PGR
38 esophagus adenocarcinoma 10.2 ERBB2 TP53
39 glassy cell carcinoma of the cervix 10.2 ERBB2 PGR
40 breast mucoepidermoid carcinoma 10.2 ERBB2 PGR
41 breast metaplastic carcinoma 10.2 ERBB2 PGR
42 intracystic papillary adenoma 10.2 ERBB2 PGR
43 progesterone-receptor negative breast cancer 10.2 ERBB2 PGR
44 breast medullary carcinoma 10.2 ERBB2 PGR
45 breast scirrhous carcinoma 10.2 ERBB2 PGR
46 dermoid cyst 10.1 KIT PGR
47 oncocytic breast carcinoma 10.1 ERBB2 PGR
48 apocrine adenocarcinoma 10.1 ERBB2 PGR
49 smooth muscle tumor 10.1 KIT PGR
50 granulosa cell tumor of the ovary 10.1 ERBB2 TP53

Graphical network of the top 20 diseases related to Uterine Body Mixed Cancer:



Diseases related to Uterine Body Mixed Cancer
Sources

Symptoms & Phenotypes for Uterine Body Mixed Cancer

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GenomeRNAi Phenotypes related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased homologous recombination repair frequency GR00236-A-1 9.56 ARID1A PGR PPP2R1A
2 Decreased homologous recombination repair frequency GR00236-A-2 9.56 ARID1A PGR PIK3R2 PPP2R1A
3 Decreased homologous recombination repair frequency GR00236-A-3 9.56 PIK3R2
4 Increased TP53 mRNA expression GR00389-S-6 8.62 ESR2 TP53

MGI Mouse Phenotypes related to Uterine Body Mixed Cancer:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.08 ESR2 ARID1A KIT ERBB2 PIK3R2 PKP3
2 cardiovascular system MP:0005385 10.07 ERBB2 PGR ESR2 ARID1A KIT PIK3R2
3 homeostasis/metabolism MP:0005376 10.06 ERBB2 PGR ESR2 ARID1A KIT PIK3R2
4 cellular MP:0005384 10.05 KIT ERBB2 ESR2 ARID1A PKP3 TP53
5 endocrine/exocrine gland MP:0005379 9.97 KIT ERBB2 ESR2 ARID1A TP53 PGR
6 neoplasm MP:0002006 9.92 PGR ESR2 ARID1A KIT ERBB2 PIK3R2
7 integument MP:0010771 9.91 ERBB2 PGR ESR2 KIT PKP3 TP53
8 muscle MP:0005369 9.91 PGR ESR2 ARID1A KIT ERBB2 PIK3R2
9 limbs/digits/tail MP:0005371 9.8 KIT ERBB2 PGR ESR2 TP53
10 normal MP:0002873 9.76 PGR ESR2 ARID1A KIT ERBB2 PKP3
11 no phenotypic analysis MP:0003012 9.65 KIT ESR2 ARID1A PGR TP53
12 reproductive system MP:0005389 9.43 KIT ERBB2 ESR2 ARID1A TP53 PGR
13 skeleton MP:0005390 9.1 KIT ERBB2 ESR2 ARID1A TP53 PGR
Sources

Drugs & Therapeutics for Uterine Body Mixed Cancer

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Search Clinical Trials , NIH Clinical Center for Uterine Body Mixed Cancer

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Genetic Tests for Uterine Body Mixed Cancer

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Anatomical Context for Uterine Body Mixed Cancer

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Publications for Uterine Body Mixed Cancer

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Variations for Uterine Body Mixed Cancer

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Expression for Uterine Body Mixed Cancer

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Search GEO for disease gene expression data for Uterine Body Mixed Cancer.
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Pathways for Uterine Body Mixed Cancer

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Pathways related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Gene Expression 66
Show member pathways
 13.57 ERBB2 ESR2 KIT PGR PPP2R1A TP53
2
GPCR Pathway 64
Show member pathways
 13.45 ERBB2 ESR2 KIT PIK3R2 PPP2R1A TP53
3
PEDF Induced Signaling 64
Show member pathways
 13.39 ARID1A ERBB2 KIT PIK3R2 PPP2R1A TP53
4
TGF-Beta Pathway 64
Show member pathways
 13.27 ERBB2 KIT PIK3R2 PPP2R1A TP53
5
Class I MHC mediated antigen processing and presentation 66
Show member pathways
 13.21 ERBB2 KIT PIK3R2 PPP2R1A TP53
6
Akt Signaling 64
Show member pathways
 13.16 ERBB2 KIT PIK3R2 PPP2R1A TP53
7
Cytokine Signaling in Immune system 66
Show member pathways
 13.09 ERBB2 KIT PIK3R2 PPP2R1A TP53
8
Nanog in Mammalian ESC Pluripotency 64
Show member pathways
 12.99 ERBB2 ESR2 KIT PIK3R2 PPP2R1A
9
Circadian entrainment 37
Show member pathways
 12.81 ESR2 PGR PIK3R2 PPP2R1A
10
PI3K/AKT activation 66
Show member pathways
 12.79 ERBB2 KIT PIK3R2 PPP2R1A TP53
11
Endometrial cancer 37
Show member pathways
 12.61 ERBB2 KIT PIK3R2 TP53
12
PI3K-Akt signaling pathway 37
Show member pathways
 12.59 ERBB2 KIT PIK3R2 PPP2R1A TP53
13
Glioma 37
Show member pathways
 12.51 ERBB2 ESR2 PIK3R2 TP53
14
Pathways in cancer 37
12.38 ERBB2 ESR2 KIT PIK3R2 TP53
15
Apoptosis Pathway 72
Show member pathways
 12.25 ERBB2 PIK3R2 TP53
16
AMP-activated Protein Kinase (AMPK) Signaling 1
Show member pathways
 12.24 PIK3R2 PPP2R1A TP53
17
Downstream signaling events of B Cell Receptor (BCR) 66
Show member pathways
 12.19 ERBB2 KIT PIK3R2 PPP2R1A TP53
18
Oocyte meiosis 37
Show member pathways
 12.15 PGR PIK3R2 PPP2R1A
19
Development Ligand-independent activation of ESR1 and ESR2 22
Show member pathways
 12.11 ERBB2 ESR2 PIK3R2
20
Proteoglycans in cancer 37
12.07 ERBB2 PIK3R2 TP53
21
AKT Signaling Pathway 67
11.94 ERBB2 PIK3R2 TP53
22
Gastric cancer 37
Show member pathways
 11.83 ARID1A ERBB2 ESR2 KIT PGR PIK3R2
23
Hepatitis C 37
11.82 PIK3R2 PPP2R1A TP53
24
MAPK Pathway 72
Show member pathways
 11.78 ERBB2 PIK3R2 TP53
25
Sphingolipid signaling pathway 37
11.74 PIK3R2 PPP2R1A TP53
26
DNA Damage Response (only ATM dependent) 1
11.71 ERBB2 PIK3R2 TP53
27
Bladder cancer 37 1
11.47 ERBB2 PIK3R2 TP53
28
Platinum drug resistance 37
11.44 ERBB2 PIK3R2 TP53
29
Pathways Affected in Adenoid Cystic Carcinoma 1
11.32 ARID1A ERBB2 TP53
30
Ovarian Infertility Genes 1
11.13 ESR2 PGR
31
Central carbon metabolism in cancer 37
11.07 ERBB2 KIT PIK3R2 TP53
32
Inhibition of Ribosome Biogenesis by p14(ARF) 64
10.9 PIK3R2 TP53
Sources

GO Terms for Uterine Body Mixed Cancer

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Biological processes related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.88 ARID1A ERBB2 ESR2 PGR PPP2R1A TP53
2 positive regulation of protein kinase B signaling GO:0051897 9.43 ERBB2 KIT PIK3R2
3 phosphatidylinositol 3-kinase signaling GO:0014065 9.37 ERBB2 PIK3R2
4 negative regulation of cell growth GO:0030308 9.33 ESR2 PPP2R1A TP53
5 intracellular estrogen receptor signaling pathway GO:0030520 9.32 ARID1A ESR2
6 positive regulation of gene expression GO:0010628 9.26 ERBB2 KIT PKP3 TP53
7 phosphatidylinositol phosphorylation GO:0046854 8.8 ERBB2 KIT PIK3R2

Molecular functions related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.62 ERBB2 PIK3R2 PPP2R1A TP53
2 binding GO:0005488 9.58 ARID1A PKP3 PPP2R1A
3 enzyme binding GO:0019899 9.46 ESR2 PGR PKP3 TP53
4 steroid binding GO:0005496 9.37 ESR2 PGR
5 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.26 ERBB2 KIT
6 protein phosphatase binding GO:0019903 9.13 ERBB2 PIK3R2 TP53
7 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.8 ERBB2 KIT PIK3R2
Sources

Sources for Uterine Body Mixed Cancer

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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