MCID: UTR032
MIFTS: 34

Uterine Body Mixed Cancer

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Uterine Body Mixed Cancer

MalaCards integrated aliases for Uterine Body Mixed Cancer:

Name: Uterine Body Mixed Cancer 12 15
Malignant Mixed Tumor, Not Otherwise Specified 73
Malignant Mixed Tumor of Corpus Uteri 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4114
NCIt 50 C6311

Summaries for Uterine Body Mixed Cancer

Disease Ontology : 12 A uterine corpus cancer that has material basis in more than one type of cell.

MalaCards based summary : Uterine Body Mixed Cancer, also known as malignant mixed tumor, not otherwise specified, is related to uterine carcinosarcoma and uterine corpus adenocarcinofibroma. An important gene associated with Uterine Body Mixed Cancer is PIK3R2 (Phosphoinositide-3-Kinase Regulatory Subunit 2), and among its related pathways/superpathways are Developmental Biology and Class I MHC mediated antigen processing and presentation. Affiliated tissues include lung, brain and bone, and related phenotypes are Decreased homologous recombination repair frequency and Decreased homologous recombination repair frequency

Related Diseases for Uterine Body Mixed Cancer

Diseases related to Uterine Body Mixed Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 uterine carcinosarcoma 30.6 ERBB2 FBXW7 PGR PIK3CA PIK3R2 PPP2R1A
2 uterine corpus adenocarcinofibroma 11.2
3 endometrioid ovary carcinoma 10.2 ARID1A PPP2R1A
4 prostate squamous cell carcinoma 10.1 PPP2R1A TP53
5 cutis marmorata telangiectatica congenita 10.1 PIK3CA PIK3R2
6 megalencephaly-capillary malformation-polymicrogyria syndrome 10.1 PIK3CA PIK3R2
7 epithelial-myoepithelial carcinoma 10.1 FBXW7 TP53
8 gastric papillary adenocarcinoma 10.1 ERBB2 TP53
9 pleomorphic adenoma carcinoma 10.1 ERBB2 TP53
10 non-proliferative fibrocystic change of the breast 10.1 ERBB2 TP53
11 glioma susceptibility 1 10.1 ERBB2 TP53
12 esophagus adenocarcinoma 10.0 ERBB2 TP53
13 adult hepatocellular carcinoma 10.0 PIK3CA TP53
14 rare adenocarcinoma of the breast 10.0 PIK3CA TP53
15 malignant spiradenoma 10.0 PIK3CA TP53
16 clear cell adenofibroma 10.0 ARID1A PIK3CA
17 proteus syndrome 10.0 PIK3CA PIK3R2
18 ovarian clear cell adenocarcinoma 10.0 ARID1A PIK3CA
19 granulosa cell tumor of the ovary 10.0 ERBB2 TP53
20 hidradenocarcinoma 10.0 ERBB2 TP53
21 acneiform dermatitis 10.0 ERBB2 PIK3CA
22 congenital lipomatous overgrowth, vascular malformations, and epidermal nevi 10.0 PIK3CA PIK3R2
23 tonsil cancer 10.0 ERBB2 TP53
24 barrett's adenocarcinoma 10.0 ERBB2 TP53
25 endometrium carcinoma in situ 10.0 PGR TP53
26 scirrhous adenocarcinoma 10.0 ERBB2 PGR
27 breast apocrine carcinoma 10.0 ERBB2 PGR
28 glassy cell carcinoma of the cervix 10.0 ERBB2 PGR
29 intracystic papillary adenoma 10.0 ERBB2 PGR
30 breast metaplastic carcinoma 10.0 ERBB2 PGR
31 adenosquamous lung carcinoma 10.0 ERBB2 PIK3CA
32 progesterone-receptor negative breast cancer 10.0 ERBB2 PGR
33 breast medullary carcinoma 10.0 ERBB2 PGR
34 breast scirrhous carcinoma 10.0 ERBB2 PGR
35 breast malignant phyllodes tumor 10.0 PGR TP53
36 progesterone-receptor positive breast cancer 10.0 ERBB2 PGR
37 olfactory groove meningioma 10.0 PGR TP53
38 breast adenoid cystic carcinoma 10.0 ERBB2 PGR
39 apocrine adenocarcinoma 10.0 ERBB2 PGR
40 synchronous bilateral breast carcinoma 10.0 PGR TP53
41 endometriosis of ovary 9.9 ARID1A PGR
42 papillary serous adenocarcinoma 9.9 PGR TP53
43 bartholin's gland disease 9.9 PGR TP53
44 female reproductive endometrioid cancer 9.9 PGR TP53
45 cervical carcinosarcoma 9.9 PGR TP53
46 glycogen-rich clear cell breast carcinoma 9.9 PGR TP53
47 anterior cranial fossa meningioma 9.9 PGR TP53
48 inflammatory breast carcinoma 9.9 ERBB2 PGR
49 adenosarcoma 9.9 PGR TP53
50 luminal breast carcinoma 9.9 ERBB2 PGR

Graphical network of the top 20 diseases related to Uterine Body Mixed Cancer:



Diseases related to Uterine Body Mixed Cancer

Symptoms & Phenotypes for Uterine Body Mixed Cancer

GenomeRNAi Phenotypes related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased homologous recombination repair frequency GR00236-A-1 9.56 ARID1A PGR PPP2R1A
2 Decreased homologous recombination repair frequency GR00236-A-2 9.56 ARID1A PGR PIK3R2 PPP2R1A
3 Decreased homologous recombination repair frequency GR00236-A-3 9.56 PIK3R2
4 Decreased CDKN1A mRNA expression GR00389-S-1 9.33 FBXW7 TP53
5 Decreased CDKN1A mRNA expression GR00389-S-2 9.33 TP53
6 Increased cell death HMECs cells GR00103-A-0 9.02 FBXW7 PGR PIK3CA PPP2R1A TP53

MGI Mouse Phenotypes related to Uterine Body Mixed Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.02 ARID1A ERBB2 FBXW7 PGR PIK3CA PIK3R2
2 cellular MP:0005384 10 ARID1A ERBB2 FBXW7 PGR PIK3CA PKP3
3 growth/size/body region MP:0005378 9.97 ARID1A ERBB2 FBXW7 PIK3CA PIK3R2 PKP3
4 homeostasis/metabolism MP:0005376 9.92 ARID1A ERBB2 FBXW7 PGR PIK3CA PIK3R2
5 embryo MP:0005380 9.91 ARID1A ERBB2 FBXW7 PGR PIK3CA TP53
6 endocrine/exocrine gland MP:0005379 9.88 ARID1A ERBB2 FBXW7 PGR PIK3CA TP53
7 integument MP:0010771 9.73 ERBB2 FBXW7 PGR PIK3CA PKP3 TP53
8 muscle MP:0005369 9.63 ARID1A ERBB2 PGR PIK3CA PIK3R2 TP53
9 neoplasm MP:0002006 9.56 ARID1A ERBB2 FBXW7 PGR PIK3CA PIK3R2
10 normal MP:0002873 9.17 ARID1A ERBB2 FBXW7 PGR PKP3 PPP2R1A

Drugs & Therapeutics for Uterine Body Mixed Cancer

Search Clinical Trials , NIH Clinical Center for Uterine Body Mixed Cancer

Genetic Tests for Uterine Body Mixed Cancer

Anatomical Context for Uterine Body Mixed Cancer

MalaCards organs/tissues related to Uterine Body Mixed Cancer:

41
Lung, Brain, Bone, Ovary, Pancreas, Cervix, Thyroid

Publications for Uterine Body Mixed Cancer

Variations for Uterine Body Mixed Cancer

Expression for Uterine Body Mixed Cancer

Search GEO for disease gene expression data for Uterine Body Mixed Cancer.

Pathways for Uterine Body Mixed Cancer

Pathways related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.33 ERBB2 PIK3CA PIK3R2 PKP3 PPP2R1A
2
Show member pathways
13.25 ERBB2 FBXW7 PIK3CA PIK3R2 PPP2R1A TP53
3
Show member pathways
13.2 ERBB2 PIK3CA PIK3R2 PPP2R1A TP53
4
Show member pathways
12.95 ERBB2 PIK3CA PIK3R2 PPP2R1A TP53
5
Show member pathways
12.88 PGR PIK3CA PIK3R2 PPP2R1A
6
Show member pathways
12.8 ERBB2 PIK3CA PIK3R2 PPP2R1A TP53
7
Show member pathways
12.73 ERBB2 PIK3CA PIK3R2 TP53
8 12.7 ERBB2 PIK3CA PIK3R2 TP53
9
Show member pathways
12.62 ERBB2 PIK3CA PIK3R2 TP53
10
Show member pathways
12.58 ERBB2 PIK3CA PIK3R2 TP53
11
Show member pathways
12.49 ERBB2 PIK3CA PIK3R2 PPP2R1A TP53
12
Show member pathways
12.44 ERBB2 PIK3CA PIK3R2 TP53
13
Show member pathways
12.39 ERBB2 PIK3CA PIK3R2 TP53
14 12.37 ERBB2 PIK3CA PIK3R2 TP53
15
Show member pathways
12.35 ERBB2 PIK3CA PIK3R2 TP53
16
Show member pathways
12.32 ERBB2 PIK3CA PIK3R2 TP53
17 12.3 PIK3CA PIK3R2 TP53
18
Show member pathways
12.27 PIK3CA PIK3R2 TP53
19
Show member pathways
12.25 PIK3CA PIK3R2 PPP2R1A TP53
20
Show member pathways
12.25 ERBB2 PIK3CA PIK3R2 TP53
21
Show member pathways
12.2 ERBB2 PIK3CA PIK3R2
22
Show member pathways
12.18 PIK3CA PIK3R2 TP53
23 12.18 PIK3CA PIK3R2 TP53
24 12.17 PIK3CA PIK3R2 TP53
25
Show member pathways
12.16 PGR PIK3CA PIK3R2 PPP2R1A
26 12.1 ERBB2 PIK3CA PIK3R2 TP53
27
Show member pathways
12.1 ARID1A ERBB2 PGR PIK3CA PIK3R2 TP53
28
Show member pathways
12.09 PIK3CA PIK3R2 PPP2R1A
29 12.05 PIK3CA PIK3R2 TP53
30
Show member pathways
12.05 PIK3CA PIK3R2 TP53
31
Show member pathways
12.03 ERBB2 PIK3CA PIK3R2 TP53
32
Show member pathways
12.02 ERBB2 PIK3CA PIK3R2
33
Show member pathways
12.01 PIK3CA PIK3R2 TP53
34 11.97 PIK3CA PIK3R2 TP53
35 11.93 ERBB2 PIK3CA PIK3R2 TP53
36 11.88 PIK3CA PIK3R2 TP53
37 11.85 PIK3CA PIK3R2 PPP2R1A TP53
38
Show member pathways
11.84 ERBB2 PGR PIK3CA
39 11.8 ERBB2 PIK3CA PIK3R2
40
Show member pathways
11.8 ERBB2 PIK3CA PIK3R2 TP53
41 11.76 PIK3CA PIK3R2 TP53
42 11.74 PIK3CA PIK3R2 PPP2R1A TP53
43 11.68 ERBB2 PIK3CA PIK3R2 TP53
44 11.62 ERBB2 PIK3R2 TP53
45
Show member pathways
11.51 ERBB2 PIK3CA PIK3R2
46 11.42 ERBB2 PIK3CA PIK3R2 TP53
47 11.33 PIK3CA PIK3R2
48 11.28 PIK3CA PIK3R2
49 11.27 ERBB2 PIK3CA PIK3R2
50 11.27 ERBB2 PIK3CA PIK3R2 TP53

GO Terms for Uterine Body Mixed Cancer

Cellular components related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol 3-kinase complex GO:0005942 8.62 PIK3CA PIK3R2

Biological processes related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.33 ERBB2 PIK3CA PIK3R2
2 ERBB2 signaling pathway GO:0038128 9.32 ERBB2 PIK3CA
3 vasculature development GO:0001944 9.26 FBXW7 PIK3CA
4 phosphatidylinositol phosphorylation GO:0046854 9.13 ERBB2 PIK3CA PIK3R2
5 phosphatidylinositol 3-kinase signaling GO:0014065 8.8 ERBB2 PIK3CA PIK3R2

Molecular functions related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.46 ERBB2 PIK3R2 PPP2R1A TP53
2 protein phosphatase binding GO:0019903 9.13 ERBB2 PIK3R2 TP53
3 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.8 ERBB2 PIK3CA PIK3R2

Sources for Uterine Body Mixed Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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