Uterine Body Mixed Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: UTR032 MIFTS: 34	Uterine Body Mixed Cancer Categories: Cancer diseases, Reproductive diseases
Genes Tissues Related diseases Pathways Expand all tables

Sources

Aliases & Classifications for Uterine Body Mixed Cancer

MalaCards integrated aliases for Uterine Body Mixed Cancer:

Name: Uterine Body Mixed Cancer ¹² ¹⁵

Malignant Mixed Tumor, Not Otherwise Specified ⁷⁴

Malignant Mixed Tumor of Corpus Uteri ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4114

NCIt ⁵¹ C6311

UMLS ⁷⁴ C1334628 C4054577

Sources

Summaries for Uterine Body Mixed Cancer

Disease Ontology : ¹² A uterine corpus cancer that has material basis in more than one type of cell.

MalaCards based summary : Uterine Body Mixed Cancer, also known as malignant mixed tumor, not otherwise specified, is related to uterine carcinosarcoma and uterine corpus adenocarcinofibroma. An important gene associated with Uterine Body Mixed Cancer is PPP2R1A (Protein Phosphatase 2 Scaffold Subunit Aalpha), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Circadian entrainment. Affiliated tissues include ovary, skin and brain, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Sources

Related Diseases for Uterine Body Mixed Cancer

Diseases related to Uterine Body Mixed Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)

#	Related Disease	Score	Top Affiliating Genes
1	uterine carcinosarcoma	30.0	ERBB2 ESR2 FBXW7 PGR PIK3CA PPP2R1A
2	uterine corpus adenocarcinofibroma	11.3
3	endometrioid ovary carcinoma	10.3	ARID1A PPP2R1A
4	prostate squamous cell carcinoma	10.3	PPP2R1A TP53
5	epithelial-myoepithelial carcinoma	10.2	FBXW7 TP53
6	gastric papillary adenocarcinoma	10.2	ERBB2 TP53
7	pleomorphic adenoma carcinoma	10.2	ERBB2 TP53
8	non-proliferative fibrocystic change of the breast	10.2	ERBB2 TP53
9	glioma susceptibility 1	10.2	ERBB2 TP53
10	adult hepatocellular carcinoma	10.1	PIK3CA TP53
11	rare adenocarcinoma of the breast	10.1	PIK3CA TP53
12	esophagus adenocarcinoma	10.1	ERBB2 TP53
13	malignant spiradenoma	10.1	PIK3CA TP53
14	granulosa cell tumor of the ovary	10.1	ERBB2 TP53
15	hidradenocarcinoma	10.1	ERBB2 TP53
16	clear cell adenofibroma	10.1	ARID1A PIK3CA
17	tonsil cancer	10.1	ERBB2 TP53
18	barrett's adenocarcinoma	10.0	ERBB2 TP53
19	lobular neoplasia	10.0	ERBB2 ESR2
20	endometrium carcinoma in situ	10.0	PGR TP53
21	breast malignant phyllodes tumor	10.0	PGR TP53
22	olfactory groove meningioma	10.0	PGR TP53
23	synchronous bilateral breast carcinoma	10.0	PGR TP53
24	papillary serous adenocarcinoma	10.0	PGR TP53
25	bartholin's gland disease	10.0	PGR TP53
26	female reproductive endometrioid cancer	10.0	PGR TP53
27	cervical carcinosarcoma	10.0	PGR TP53
28	glycogen-rich clear cell breast carcinoma	10.0	PGR TP53
29	acneiform dermatitis	10.0	ERBB2 PIK3CA
30	anterior cranial fossa meningioma	10.0	PGR TP53
31	anal squamous cell carcinoma	10.0	FBXW7 PIK3CA TP53
32	adenosarcoma	10.0	PGR TP53
33	skin squamous cell carcinoma	10.0	FBXW7 PIK3CA TP53
34	penile cancer	10.0	PIK3CA TP53
35	scirrhous adenocarcinoma	10.0	ERBB2 PGR
36	breast apocrine carcinoma	10.0	ERBB2 PGR
37	glassy cell carcinoma of the cervix	10.0	ERBB2 PGR
38	intracystic papillary adenoma	9.9	ERBB2 PGR
39	breast metaplastic carcinoma	9.9	ERBB2 PGR
40	progesterone-receptor negative breast cancer	9.9	ERBB2 PGR
41	breast medullary carcinoma	9.9	ERBB2 PGR
42	breast scirrhous carcinoma	9.9	ERBB2 PGR
43	adenosquamous lung carcinoma	9.9	ERBB2 PIK3CA
44	progesterone resistance	9.9	ESR2 PGR
45	apocrine adenocarcinoma	9.9	ERBB2 PGR
46	gender identity disorder	9.9	ESR2 PGR
47	breast adenoid cystic carcinoma	9.9	ERBB2 PGR
48	estrogen excess	9.9	ESR2 PGR
49	inflammatory breast carcinoma	9.9	ERBB2 PGR
50	adenocarcinoma	9.9	ERBB2 PIK3CA TP53

Graphical network of the top 20 diseases related to Uterine Body Mixed Cancer:

Sources

Symptoms & Phenotypes for Uterine Body Mixed Cancer

GenomeRNAi Phenotypes related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

²⁷ (show all 25)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-114	10.02	ARID1A
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-116	10.02	PIK3CA
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-12	10.02	TP53
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-120	10.02	TP53
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-132	10.02	TP53
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-157	10.02	PIK3CA
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-16	10.02	PIK3CA
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-166	10.02	PIK3CA
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-168	10.02	ARID1A
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-169	10.02	TP53
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-176	10.02	ARID1A
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-177	10.02	PIK3CA
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-186	10.02	ARID1A
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-19	10.02	TP53
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-190	10.02	ARID1A PIK3CA TP53
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-35	10.02	TP53
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-39	10.02	TP53
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-42	10.02	PIK3CA
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-43	10.02	ARID1A
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-49	10.02	PIK3CA
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-73	10.02	ARID1A
22	Increased cell death HMECs cells	GR00103-A-0	9.55	FBXW7 PGR PIK3CA PPP2R1A TP53
23	Decreased CDKN1A mRNA expression	GR00389-S-1	9.43	FBXW7 TP53
24	Decreased CDKN1A mRNA expression	GR00389-S-2	9.43	TP53
25	Increased TP53 mRNA expression	GR00389-S-6	8.62	ESR2 TP53

MGI Mouse Phenotypes related to Uterine Body Mixed Cancer:

⁴⁷ (show all 15)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10.14	ARID1A ERBB2 ESR2 FBXW7 PGR PIK3CA
2	growth/size/body region	MP:0005378	10.1	ARID1A ERBB2 ESR2 FBXW7 PIK3CA PKP3
3	cardiovascular system	MP:0005385	10.09	ARID1A ERBB2 ESR2 FBXW7 PGR PIK3CA
4	homeostasis/metabolism	MP:0005376	10.08	ARID1A ERBB2 ESR2 FBXW7 PGR PIK3CA
5	endocrine/exocrine gland	MP:0005379	10.05	ARID1A ERBB2 ESR2 FBXW7 PGR PIK3CA
6	mortality/aging	MP:0010768	10.01	ARID1A ERBB2 ESR2 FBXW7 PGR PIK3CA
7	embryo	MP:0005380	10	ARID1A ERBB2 FBXW7 PGR PIK3CA TP53
8	immune system	MP:0005387	10	ARID1A ESR2 FBXW7 PGR PIK3CA PKP3
9	integument	MP:0010771	9.98	ERBB2 ESR2 FBXW7 PGR PIK3CA PKP3
10	neoplasm	MP:0002006	9.92	ARID1A ERBB2 ESR2 FBXW7 PGR PIK3CA
11	muscle	MP:0005369	9.85	ARID1A ERBB2 ESR2 PGR PIK3CA TP53
12	normal	MP:0002873	9.76	ARID1A ERBB2 ESR2 FBXW7 PGR PKP3
13	no phenotypic analysis	MP:0003012	9.65	ARID1A ESR2 PGR PIK3CA TP53
14	reproductive system	MP:0005389	9.43	ARID1A ERBB2 ESR2 PGR PIK3CA TP53
15	skeleton	MP:0005390	9.1	ARID1A ERBB2 ESR2 PGR PIK3CA TP53

Sources

Drugs & Therapeutics for Uterine Body Mixed Cancer

Search Clinical Trials , NIH Clinical Center for Uterine Body Mixed Cancer

Sources

Genetic Tests for Uterine Body Mixed Cancer

Sources

Anatomical Context for Uterine Body Mixed Cancer

MalaCards organs/tissues related to Uterine Body Mixed Cancer:

⁴²

Ovary, Skin, Brain, Cervix, Pancreas, Tonsil

Sources

Publications for Uterine Body Mixed Cancer

Sources

Genes for Uterine Body Mixed Cancer

Genes related to Uterine Body Mixed Cancer (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	14.78	DISEASES inferred ¹⁵
2	FBXW7	F-Box And WD Repeat Domain Containing 7	Protein Coding	14.7	DISEASES inferred ¹⁵
3	TP53	Tumor Protein P53	Protein Coding	14.7	DISEASES inferred ¹⁵
4	ARID1A	AT-Rich Interaction Domain 1A	Protein Coding	14.61	DISEASES inferred ¹⁵
5	PKP3	Plakophilin 3	Protein Coding	14.61	DISEASES inferred ¹⁵
6	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	14.55	DISEASES inferred ¹⁵
7	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	14.54	DISEASES inferred ¹⁵
8	PGR	Progesterone Receptor	Protein Coding	14.5	DISEASES inferred ¹⁵
9	ESR2	Estrogen Receptor 2	Protein Coding	14.45	DISEASES inferred ¹⁵

Sources

Variations for Uterine Body Mixed Cancer

Sources

Expression for Uterine Body Mixed Cancer

Search GEO for disease gene expression data for Uterine Body Mixed Cancer.

Sources

Pathways for Uterine Body Mixed Cancer

Pathways related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

(show all 28)

#	Super pathways	Score	Top Affiliating Genes
1	Class I MHC mediated antigen processing and presentation ⁶⁷ Show member pathways Adaptive Immune System ⁶⁷ Antigen processing- Ubiquitination and Proteasome degradation ⁶⁷	13.17	ERBB2 FBXW7 PIK3CA PPP2R1A TP53
2	Circadian entrainment ³⁸ Show member pathways Cholinergic synapse ³⁸ Dopaminergic synapse ³⁸ Estrogen signaling pathway ³⁸ Glutamatergic synapse ³⁸ Relaxin receptors ⁶⁷ Relaxin signaling pathway ³⁸ Synaptic Neurotransmission Pathways: Glutamatergic Excitation ⁶⁶	12.77	ESR2 PGR PIK3CA PPP2R1A
3	PI3K-Akt signaling pathway ³⁸ Show member pathways Human papillomavirus infection ³⁸	12.72	ERBB2 PIK3CA PPP2R1A TP53
4	Pathways in cancer ³⁸	12.52	ERBB2 ESR2 PIK3CA TP53
5	Downstream signaling events of B Cell Receptor (BCR) ⁶⁷ Show member pathways Activation of RAS in B cells ⁶⁷ Signaling by the B Cell Receptor (BCR) ⁶⁷	12.4	ERBB2 PIK3CA PPP2R1A TP53
6	Glioma ³⁸ Show member pathways Endocrine resistance ³⁸ Melanoma ³⁸ Non-small cell lung cancer ³⁸ Signaling Pathways in Glioblastoma ¹	12.37	ERBB2 ESR2 PIK3CA TP53
7	ErbB signaling pathway ¹ ³⁸ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶² EGFR tyrosine kinase inhibitor resistance ³⁸ Renal cell carcinoma ³⁸ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.35	ERBB2 PIK3CA TP53
8	MicroRNAs in cancer ³⁸	12.29	ERBB2 PIK3CA TP53
9	mTOR signaling pathway (KEGG) ³⁸ Show member pathways mTOR Signaling Pathway ⁶⁶	12.27	ERBB2 PIK3CA TP53
10	Prolactin Signaling Pathway ¹ ³⁸ Show member pathways Development Prolactin receptor signaling ²³ Leptin signaling pathway ¹	12.26	ERBB2 ESR2 PIK3CA
11	AMP-activated Protein Kinase (AMPK) Signaling ¹ Show member pathways AMPK signaling pathway ³⁸ AMPK Signaling Pathway ⁶⁸	12.2	PIK3CA PPP2R1A TP53
12	Apoptosis Pathway ⁷³ Show member pathways Akt Pathway ⁷³ NF-kappaB Pathway ⁷³	12.2	ERBB2 PIK3CA TP53
13	Gastric cancer ³⁸ Show member pathways Breast cancer ³⁸ Hepatocellular carcinoma ³⁸	12.1	ARID1A ERBB2 ESR2 PGR PIK3CA TP53
14	Oocyte meiosis ³⁸ Show member pathways Progesterone-mediated oocyte maturation ³⁸	12.09	PGR PIK3CA PPP2R1A
15	Development Ligand-independent activation of ESR1 and ESR2 ²³ Show member pathways Transcription CREB pathway ²³ Transcription PPAR Pathway ²³	12.05	ERBB2 ESR2 PIK3CA
16	Proteoglycans in cancer ³⁸	12.02	ERBB2 PIK3CA TP53
17	MAPK Signaling: Mitogen Stimulation Pathway ⁶⁶ Show member pathways Akt Signaling Pathway ⁶⁶	11.98	ERBB2 PIK3CA TP53
18	AKT Signaling Pathway ⁶⁸	11.84	ERBB2 PIK3CA TP53
19	MAPK Pathway ⁷³ Show member pathways Toll-like Receptor Pathway ⁷³	11.7	ERBB2 PIK3CA TP53
20	Sphingolipid signaling pathway ³⁸	11.66	PIK3CA PPP2R1A TP53
21	DNA Damage Response (only ATM dependent) ¹	11.6	ERBB2 PIK3CA TP53
22	Signaling by ERBB4 ⁶⁷ Show member pathways Downregulation of ERBB4 signaling ⁶⁷ ErbB4 signaling events ¹ Nuclear signaling by ERBB4 ⁶⁷	11.53	ERBB2 PGR PIK3CA
23	Platinum drug resistance ³⁸	11.3	ERBB2 PIK3CA TP53
24	Central carbon metabolism in cancer ³⁸	11.14	ERBB2 PIK3CA TP53
25	Ovarian Infertility Genes ¹	11.08	ESR2 PGR
26	a6b1 and a6b4 Integrin signaling ¹	11.05	ERBB2 PIK3CA
27	Plasma membrane estrogen receptor signaling ¹	10.94	ESR2 PIK3CA
28	Pathways Affected in Adenoid Cystic Carcinoma ¹	10.84	ARID1A ERBB2 FBXW7 PIK3CA TP53

Sources

GO Terms for Uterine Body Mixed Cancer

Cellular components related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:0005634	9.56	ARID1A ERBB2 ESR2 FBXW7 PGR PKP3
2	mitochondrion	GO:0005739	9.02	ESR2 FBXW7 PGR PPP2R1A TP53

Biological processes related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	phosphatidylinositol 3-kinase signaling	GO:0014065	9.32	ERBB2 PIK3CA
2	ERBB2 signaling pathway	GO:0038128	9.26	ERBB2 PIK3CA
3	vasculature development	GO:0001944	9.16	FBXW7 PIK3CA
4	intracellular estrogen receptor signaling pathway	GO:0030520	8.96	ARID1A ESR2
5	negative regulation of cell growth	GO:0030308	8.8	ESR2 PPP2R1A TP53

Molecular functions related to Uterine Body Mixed Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.35	ERBB2 ESR2 FBXW7 PGR TP53
2	nuclear receptor activity	GO:0004879	9.26	ESR2 PGR
3	steroid binding	GO:0005496	9.16	ESR2 PGR
4	enzyme binding	GO:0019899	8.92	ESR2 PGR PKP3 TP53

Sources

Sources for Uterine Body Mixed Cancer

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia