MCID: UTR056
MIFTS: 27

Uterine Corpus Endometrial Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Uterine Corpus Endometrial Carcinoma

MalaCards integrated aliases for Uterine Corpus Endometrial Carcinoma:

Name: Uterine Corpus Endometrial Carcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050939

Summaries for Uterine Corpus Endometrial Carcinoma

Disease Ontology : 12 A uterine corpus cancer that is derives from the inner lining of the uterus.

MalaCards based summary : Uterine Corpus Endometrial Carcinoma is related to endometrial cancer and thyroid hurthle cell adenoma. An important gene associated with Uterine Corpus Endometrial Carcinoma is LYL1 (LYL1 Basic Helix-Loop-Helix Family Member), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Gastric cancer. Affiliated tissues include uterus, breast and neutrophil, and related phenotype is neoplasm.

Related Diseases for Uterine Corpus Endometrial Carcinoma

Diseases related to Uterine Corpus Endometrial Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 endometrial cancer 30.9 TP53 PTEN PPP2R1A POLE PIK3R1 PIK3CA
2 thyroid hurthle cell adenoma 10.6 PTEN PIK3CA
3 rare head and neck tumor 10.6 TP53 PIK3CA
4 ovarian clear cell adenofibroma 10.6 PTEN PIK3CA
5 rare adenocarcinoma of the breast 10.5 TP53 PIK3CA
6 cystadenocarcinoma 10.5 TP53 PPP2R1A PIK3CA
7 rectum adenocarcinoma 10.5 TP53 SLC25A16 PIK3CA
8 clear cell adenofibroma 10.5 PPP2R1A PIK3CA ARID1A
9 ovarian clear cell adenocarcinoma 10.5 TP53 PIK3CA ARID1A
10 clear cell adenocarcinoma 10.5 TP53 PIK3CA ARID1A
11 large intestine adenocarcinoma 10.5 TP53 PTEN PIK3CA
12 hypertrophy of breast 10.5 TP53 PTEN PIK3CA
13 immunodeficiency 14 10.5 PTEN PIK3R1
14 thyroid tumor 10.4 TP53 PTEN PIK3CA
15 uterine benign neoplasm 10.4 TP53 PTEN ARID1A
16 luminal breast carcinoma a 10.4 TP53 PTEN PIK3CA
17 giant cell glioblastoma 10.4 TP53 PTEN POLE
18 endocervical carcinoma 10.4 U2AF1 TP53 SLC25A16 PIK3CA
19 proteus syndrome 10.4 PTEN PIK3R1 PIK3CA
20 endocervical adenocarcinoma 10.4 U2AF1 TP53 SLC25A16 PIK3CA
21 brain stem glioma 10.4 TP53 PTEN PIK3CA
22 penile cancer 10.4 TP53 PTEN PIK3CA
23 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 10.4 TP53 POLE PIK3R1
24 pre-malignant neoplasm 10.4 TP53 PTEN PIK3CA
25 adenosquamous carcinoma 10.4 TP53 PTEN PIK3CA
26 in situ carcinoma 10.4 TP53 PTEN PIK3CA
27 ovarian carcinosarcoma 10.4 TP53 PPP2R1A PIK3CA ARID1A
28 small cell cancer of the lung 10.4 U2AF1 TP53 PTEN PIK3CA
29 intestinal benign neoplasm 10.4 TP53 PTEN PIK3CA
30 infratentorial cancer 10.4 U2AF1 TP53 PTEN
31 transitional cell carcinoma 10.4 U2AF1 TP53 PTEN PIK3CA
32 parameningeal embryonal rhabdomyosarcoma 10.3 TP53 PIK3CA
33 melanoma, cutaneous malignant 1 10.3 TP53 PTEN POLE PIK3CA
34 t-cell acute lymphoblastic leukemia 10.3 U2AF1 TP53 PTEN LYL1
35 rare cancer of corpus uteri 10.3 TP53 PTEN PPP2R1A PIK3CA
36 endometrial hyperplasia 10.3 TP53 PTEN ARID1A
37 cowden syndrome 1 10.3 TP53 PTEN PIK3R1 PIK3CA
38 adenocarcinoma 10.3 U2AF1 TP53 PTEN POLE PIK3CA
39 hereditary breast ovarian cancer syndrome 10.3 TP53 PTEN POLE
40 melanoma, uveal 10.3 U2AF1 TP53 PTEN PIK3CA HLA-A
41 ovarian cystadenocarcinoma 10.3 TP53 SLC25A16 PTEN PIK3CA ARID1A
42 ovary epithelial cancer 10.3 U2AF1 TP53 PTEN PIK3CA ARID1A
43 suppression of tumorigenicity 12 10.3 U2AF1 TP53 SLC25A16 PTEN PIK3CA
44 malignant ovarian surface epithelial-stromal neoplasm 10.3 U2AF1 TP53 PTEN PIK3CA ARID1A
45 intrahepatic cholangiocarcinoma 10.3 TP53 PTEN ARID1A
46 ductal carcinoma in situ 10.3 TP53 PTEN PIK3CA
47 carcinosarcoma 10.3 TP53 PTEN PPP2R1A POLE PIK3CA
48 lynch syndrome 10.3 TP53 PTEN POLE PIK3CA ARID1A
49 skin melanoma 10.3 U2AF1 TP53 PTEN
50 ovarian clear cell carcinoma 10.3 TP53 PTEN PPP2R1A PIK3CA ARID1A

Graphical network of the top 20 diseases related to Uterine Corpus Endometrial Carcinoma:



Diseases related to Uterine Corpus Endometrial Carcinoma

Symptoms & Phenotypes for Uterine Corpus Endometrial Carcinoma

MGI Mouse Phenotypes related to Uterine Corpus Endometrial Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.23 ARID1A PIK3CA PIK3R1 POLE PPP2R1A PTEN

Drugs & Therapeutics for Uterine Corpus Endometrial Carcinoma

Search Clinical Trials , NIH Clinical Center for Uterine Corpus Endometrial Carcinoma

Genetic Tests for Uterine Corpus Endometrial Carcinoma

Anatomical Context for Uterine Corpus Endometrial Carcinoma

MalaCards organs/tissues related to Uterine Corpus Endometrial Carcinoma:

40
Uterus, Breast, Neutrophil

Publications for Uterine Corpus Endometrial Carcinoma

Articles related to Uterine Corpus Endometrial Carcinoma:

(show top 50) (show all 56)
# Title Authors PMID Year
1
PTEN mutation: A potential prognostic factor associated with immune infiltration in endometrial carcinoma. 61
32279917 2020
2
A 14-Methylation-Driven Differentially Expressed RNA as a Signature for Overall Survival Prediction in Patients with Uterine Corpus Endometrial Carcinoma. 61
32397815 2020
3
Ancestry-specific predisposing germline variants in cancer. 61
32471518 2020
4
Pan‑cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS‑CoV‑2 infection leading to COVID-19. 61
32468052 2020
5
Prognostic significance of immune landscape in tumour microenvironment of endometrial cancer. 61
32424934 2020
6
A comprehensive analysis of IDO1 expression with tumour-infiltrating immune cells and mutation burden in gynaecologic and breast cancers. 61
32227579 2020
7
ACE2 correlated with immune infiltration serves as a prognostic biomarker in endometrial carcinoma and renal papillary cell carcinoma: implication for COVID-19. 61
32339157 2020
8
Identification of a Multi-RNA-Type-Based Signature for Recurrence-Free Survival Prediction in Patients with Uterine Corpus Endometrial Carcinoma. 61
32105510 2020
9
Prognostic significance of mutant-allele tumor heterogeneity in uterine corpus endometrial carcinoma. 61
32355783 2020
10
The pan-cancer landscape of netrin family reveals potential oncogenic biomarkers. 61
32251318 2020
11
Cooperative driver pathway discovery via fusion of multi-relational data of genes, miRNAs and pathways. 61
32103253 2020
12
Comprehensive bioinformatic analysis of Wnt1 and Wnt1-associated diseases. 61
32201670 2020
13
Bioinformatics Analysis of Global Proteomic and Phosphoproteomic Data Sets Revealed Activation of NEK2 and AURKA in Cancers. 61
32033228 2020
14
Triple-high expression of phosphatase and tensin homolog (PTEN), estrogen receptor (ER) and progesterone receptor (PR) may predict favorable prognosis for patients with Type I endometrial carcinoma. 61
32047550 2020
15
Machine Learning Supports Long Noncoding RNAs as Expression Markers for Endometrial Carcinoma. 61
32420338 2020
16
Comprehensive analysis of LDHAP5 pseudogene expression and potential pathogenesis in ovarian serous cystadenocarcinoma. 61
32536817 2020
17
Identification of hub genes and key pathways associated with the progression of gynecological cancer. 61
31788113 2019
18
Efficient Gaussian sample specific network marker discovery and drug enrichment analysis validation. 61
31751888 2019
19
Construction of a Competitive Endogenous RNA Network in Uterine Corpus Endometrial Carcinoma. 61
31650984 2019
20
A 7-lncRNA signature predict prognosis of Uterine corpus endometrial carcinoma. 61
31168849 2019
21
Advancing Pan-cancer Gene Expression Survial Analysis by Inclusion of Non-coding RNA. 61
31607216 2019
22
Expression of long non-coding RNA ANRIL predicts a poor prognosis in intrahepatic cholangiocarcinoma. 61
31040073 2019
23
A Shallow Convolutional Learning Network for Classification of Cancers Based on Copy Number Variations. 61
31569801 2019
24
Alteration of tumor associated neutrophils by PIK3CA expression in endometrial carcinoma from TCGA data. 61
31472672 2019
25
DNA Methylation Module Network-Based Prognosis and Molecular Typing of Cancer. 61
31357729 2019
26
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism. 61
31221981 2019
27
Dual prognostic role of 2-oxoglutarate-dependent oxygenases in ten cancer types: implications for cell cycle regulation and cell adhesion maintenance. 61
31036064 2019
28
A six-microRNA signature predicts survival of patients with uterine corpus endometrial carcinoma. 61
29567372 2019
29
The prevalence of germline DICER1 pathogenic variation in cancer populations. 61
30672147 2019
30
TRB-J1 usage, in combination with the HLA-A*01:01 allele, represents an apparent survival advantage for uterine corpus endometrial carcinoma: Comparisons with microscopic assessments of lymphocyte infiltrates. 61
30474304 2019
31
CeModule: an integrative framework for discovering regulatory patterns from genomic data in cancer. 61
30732558 2019
32
Epigenetic-Mediated Downregulation of Zinc Finger Protein 671 (ZNF671) Predicts Poor Prognosis in Multiple Solid Tumors. 61
31134149 2019
33
A Novel Set of WNT Pathway Effectors as a Predictive Marker of Uterine Corpus Endometrial Carcinoma-Study Based on Weighted Co-expression Matrices. 61
31134156 2019
34
In silico analysis reveals a shared immune signature in CASP8-mutated carcinomas with varying correlations to prognosis. 61
30775178 2019
35
Prognostic Value of MicroRNA-15a in Human Cancers: A Meta-Analysis and Bioinformatics. 61
31061821 2019
36
Mutation Frequencies in Endometrial Cancer Patients of Different Ethnicities and Tumor Grades: An Analytical Study. 61
30787852 2019
37
Genome-wide characterization of aberrant DNA methylation patterns and the potential clinical implications in patients with endometrial cancer. 61
30449607 2019
38
PIK3CA Amplification Associates with Aggressive Phenotype but Not Markers of AKT-MTOR Signaling in Endometrial Carcinoma. 61
30442683 2019
39
A long noncoding RNAs signature to improve survival prediction in endometrioid endometrial cancer. 61
30548294 2018
40
Identification of a six-gene signature with prognostic value for patients with endometrial carcinoma. 61
30306731 2018
41
Distribution-based measures of tumor heterogeneity are sensitive to mutation calling and lack strong clinical predictive power. 61
30061557 2018
42
Two critical positions in zinc finger domains are heavily mutated in three human cancer types. 61
29953437 2018
43
LYL1 gene amplification predicts poor survival of patients with uterine corpus endometrial carcinoma: analysis of the Cancer genome atlas data. 61
29716549 2018
44
A Novel Target of p53, TCF21, Can Respond to Hypoxia by MAPK Pathway Inactivation in Uterine Corpus Endometrial Carcinoma. 61
29608330 2018
45
Minichromosome maintenance complex component 6 (MCM6) expression correlates with histological grade and survival in endometrioid endometrial adenocarcinoma. 61
29243125 2018
46
Bioinformatics analysis of RNA sequencing data reveals multiple key genes in uterine corpus endometrial carcinoma. 61
29387216 2018
47
Association Analysis between Body Mass Index and Genomic DNA Methylation across 15 Major Cancer Types. 61
30026852 2018
48
MiR-29a-5p inhibits proliferation and invasion and induces apoptosis in endometrial carcinoma via targeting TPX2. 61
29888640 2018
49
Neuritin 1 expression in human normal tissues and its association with various human cancers. 61
31938301 2018
50
Evaluation on the diagnostic and prognostic values of long non-coding RNA BLACAT1 in common types of human cancer. 61
29037201 2017

Variations for Uterine Corpus Endometrial Carcinoma

Expression for Uterine Corpus Endometrial Carcinoma

Search GEO for disease gene expression data for Uterine Corpus Endometrial Carcinoma.

Pathways for Uterine Corpus Endometrial Carcinoma

Pathways related to Uterine Corpus Endometrial Carcinoma according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.79 TP53 PTEN PPP2R1A PIK3R1 PIK3CA HLA-A
2
Show member pathways
12.63 TP53 PTEN PIK3R1 PIK3CA ARID1A
3
Show member pathways
12.56 TP53 PTEN PPP2R1A PIK3R1 PIK3CA
4
Show member pathways
12.39 TP53 PTEN PIK3R1 PIK3CA
5
Show member pathways
12.37 TP53 PPP2R1A PIK3R1 PIK3CA
6 12.28 U2AF1 TP53 PIK3R1 PIK3CA
7
Show member pathways
12.27 TP53 PTEN PIK3R1 PIK3CA
8
Show member pathways
12.17 TP53 PTEN PIK3R1 PIK3CA
9 12.15 TP53 PIK3R1 PIK3CA HLA-A
10 12.06 TP53 PTEN PIK3R1 PIK3CA HLA-A
11 11.8 PPP2R1A PIK3R1 PIK3CA
12 11.79 TP53 PTEN PIK3R1 PIK3CA
13 11.74 PTEN PIK3R1 PIK3CA
14 11.63 TP53 PTEN PIK3R1 PIK3CA
15 11.62 TP53 PIK3R1 PIK3CA
16
Show member pathways
11.55 TP53 PIK3R1 PIK3CA
17 11.55 TP53 PTEN PIK3R1 PIK3CA HLA-A
18 11.42 PTEN PIK3R1 PIK3CA
19 11.4 TP53 PTEN PIK3CA
20 11.4 TP53 PTEN PIK3R1 PIK3CA
21 11.28 TP53 PTEN PIK3CA ARID1A
22 11.25 PTEN PIK3R1 PIK3CA
23 11.1 TP53 PTEN PPP2R1A PIK3R1 PIK3CA
24 11.06 PTEN PIK3R1 PIK3CA
25 10.75 PIK3R1 PIK3CA

GO Terms for Uterine Corpus Endometrial Carcinoma

Cellular components related to Uterine Corpus Endometrial Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol 3-kinase complex, class IA GO:0005943 8.62 PIK3R1 PIK3CA

Biological processes related to Uterine Corpus Endometrial Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol biosynthetic process GO:0006661 9.13 PTEN PIK3R1 PIK3CA
2 phosphatidylinositol 3-kinase signaling GO:0014065 8.8 PTEN PIK3R1 PIK3CA

Molecular functions related to Uterine Corpus Endometrial Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor substrate binding GO:0043560 8.62 PIK3R1 PIK3CA

Sources for Uterine Corpus Endometrial Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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