MCID: UTR056
MIFTS: 27

Uterine Corpus Endometrial Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Uterine Corpus Endometrial Carcinoma

MalaCards integrated aliases for Uterine Corpus Endometrial Carcinoma:

Name: Uterine Corpus Endometrial Carcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050939

Summaries for Uterine Corpus Endometrial Carcinoma

Disease Ontology : 12 A uterine corpus cancer that is derives from the inner lining of the uterus.

MalaCards based summary : Uterine Corpus Endometrial Carcinoma is related to endometrial cancer and thyroid hurthle cell adenoma. An important gene associated with Uterine Corpus Endometrial Carcinoma is LYL1 (LYL1 Basic Helix-Loop-Helix Family Member), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Gastric cancer. Affiliated tissues include uterus, breast and prostate, and related phenotype is neoplasm.

Related Diseases for Uterine Corpus Endometrial Carcinoma

Diseases related to Uterine Corpus Endometrial Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 endometrial cancer 10.7
2 thyroid hurthle cell adenoma 10.4 PTEN PIK3CA
3 ovarian clear cell adenofibroma 10.4 PTEN PIK3CA
4 ovarian carcinosarcoma 10.4 TP53 PIK3CA ARID1A
5 clear cell adenofibroma 10.4 PPP2R1A PIK3CA ARID1A
6 cystadenocarcinoma 10.4 TP53 PPP2R1A PIK3CA
7 large intestine adenocarcinoma 10.4 TP53 PTEN PIK3CA
8 vulvar disease 10.4 TP53 PTEN PIK3CA
9 rectum adenocarcinoma 10.4 TP53 SLC25A16 PIK3CA
10 ovarian clear cell adenocarcinoma 10.4 TP53 PIK3CA ARID1A
11 clear cell adenocarcinoma 10.4 TP53 PIK3CA ARID1A
12 lung oat cell carcinoma 10.4 TP53 PTEN PIK3CA
13 penile benign neoplasm 10.3 TP53 PIK3CA
14 vulva cancer 10.3 TP53 PTEN PIK3CA
15 oropharynx cancer 10.3 TP53 PTEN PIK3CA
16 immunodeficiency 14 10.3 PTEN PIK3R1 PIK3CA
17 endocervical carcinoma 10.3 U2AF1 TP53 SLC25A16 PIK3CA
18 penile cancer 10.3 TP53 PTEN PIK3CA
19 endocervical adenocarcinoma 10.3 U2AF1 TP53 SLC25A16 PIK3CA
20 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 10.3 TP53 POLE PIK3R1
21 pre-malignant neoplasm 10.3 TP53 PTEN PIK3CA
22 adenosquamous carcinoma 10.3 TP53 PTEN PIK3CA
23 parameningeal embryonal rhabdomyosarcoma 10.3 TP53 PIK3CA
24 in situ carcinoma 10.3 TP53 PTEN PIK3CA
25 tuberous sclerosis 1 10.3 TP53 PTEN PIK3CA
26 bladder urothelial carcinoma 10.3 U2AF1 TP53 PTEN PIK3CA
27 ovary adenocarcinoma 10.3 TP53 PTEN PIK3CA ARID1A
28 intestinal benign neoplasm 10.3 TP53 PTEN PIK3CA
29 malignant ovarian surface epithelial-stromal neoplasm 10.3 TP53 PTEN PIK3CA ARID1A
30 infratentorial cancer 10.3 U2AF1 TP53 PTEN
31 endometrial hyperplasia 10.3 TP53 PTEN ARID1A
32 ovarian serous cystadenocarcinoma 10.3 TP53 PPP2R1A PIK3CA
33 t-cell acute lymphoblastic leukemia 10.3 U2AF1 TP53 PTEN LYL1
34 ductal carcinoma in situ 10.3 TP53 PTEN PIK3CA
35 pancreatic adenocarcinoma 10.3 U2AF1 TP53 POLE PIK3CA
36 lung squamous cell carcinoma 10.3 TP53 PTEN PIK3CA ARID1A
37 acute megakaryocytic leukemia 10.3 U2AF1 TP53 PTEN
38 cowden syndrome 1 10.2 TP53 PTEN PIK3R1 PIK3CA
39 ovarian cystadenocarcinoma 10.2 TP53 SLC25A16 PTEN PIK3CA ARID1A
40 melanoma, uveal 10.2 U2AF1 TP53 PTEN PIK3CA HLA-A
41 small cell cancer of the lung 10.2 TP53 PTEN PIK3CA
42 ovary epithelial cancer 10.2 U2AF1 TP53 PTEN PIK3CA ARID1A
43 carcinosarcoma 10.2 TP53 PTEN PPP2R1A POLE PIK3CA
44 giant cell glioblastoma 10.2 TP53 PTEN POLE PIK3R1 PIK3CA
45 cervix carcinoma 10.2 U2AF1 TP53 PIK3CA
46 ovarian clear cell carcinoma 10.2 TP53 PTEN PPP2R1A PIK3CA ARID1A
47 gliosarcoma 10.2 TP53 PTEN POLE PIK3R1 PIK3CA
48 serous cystadenocarcinoma 10.2 TP53 PTEN PPP2R1A PIK3CA ARID1A
49 cowden syndrome 10.2 TP53 PTEN POLE PIK3R1 PIK3CA
50 gastric adenocarcinoma 10.2 TP53 PTEN PPP2R1A POLE PIK3CA

Graphical network of the top 20 diseases related to Uterine Corpus Endometrial Carcinoma:



Diseases related to Uterine Corpus Endometrial Carcinoma

Symptoms & Phenotypes for Uterine Corpus Endometrial Carcinoma

MGI Mouse Phenotypes related to Uterine Corpus Endometrial Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.23 ARID1A PIK3CA PIK3R1 POLE PPP2R1A PTEN

Drugs & Therapeutics for Uterine Corpus Endometrial Carcinoma

Search Clinical Trials , NIH Clinical Center for Uterine Corpus Endometrial Carcinoma

Genetic Tests for Uterine Corpus Endometrial Carcinoma

Anatomical Context for Uterine Corpus Endometrial Carcinoma

MalaCards organs/tissues related to Uterine Corpus Endometrial Carcinoma:

40
Uterus, Breast, Prostate

Publications for Uterine Corpus Endometrial Carcinoma

Articles related to Uterine Corpus Endometrial Carcinoma:

(show top 50) (show all 81)
# Title Authors PMID Year
1
ROR2 Is Epigenetically Regulated in Endometrial Cancer. 61
33494187 2021
2
Construction of a Glycolysis-related long noncoding RNA signature for predicting survival in endometrial cancer. 61
33531988 2021
3
A Five-microRNA Signature as Risk Stratification System in Uterine Corpus Endometrial Carcinoma. 61
32748742 2021
4
Tumor mutation burden in connection with immune-related survival in uterine corpus endometrial carcinoma. 61
33509222 2021
5
The Prognostic Value of DNA Methylation, Post-Translational Modifications and Correlated with Immune Infiltrates in Gynecologic Cancers. 61
33488112 2021
6
The panoramic picture of pepsinogen gene family with pan-cancer. 61
33067881 2020
7
Development of cancer prognostic signature based on pan-cancer proteomics. 61
33200655 2020
8
Prognostic value and immunological role of PDCD1 gene in pan-cancer. 61
33069926 2020
9
Pan-Cancer Multiomics Analysis of TC2N Gene Suggests its Important Role(s) in Tumourigenesis of Many Cancers. 61
33247676 2020
10
An miRNA signature associated with tumor mutation burden in endometrial cancer. 61
33141168 2020
11
Advancing Pan-cancer Gene Expression Survial Analysis by Inclusion of Non-coding RNA. 61
31607216 2020
12
ZBTB7A, a potential biomarker for prognosis and immune infiltrates, inhibits progression of endometrial cancer based on bioinformatics analysis and experiments. 61
33292231 2020
13
Identification of an immune gene signature for predicting the prognosis of patients with uterine corpus endometrial carcinoma. 61
33292199 2020
14
Pan-cancer analysis of alternative splicing regulator heterogeneous nuclear ribonucleoproteins (hnRNPs) family and their prognostic potential. 61
32915499 2020
15
The Study of the Expression of CGB1 and CGB2 in Human Cancer Tissues. 61
32957442 2020
16
Integrated analysis of tumor mutation burden and immune infiltrates in endometrial cancer. 61
33012523 2020
17
Identification of a five-gene signature for predicting the progression and prognosis of stage I endometrial carcinoma. 61
32782557 2020
18
Scanning window analysis of non-coding regions within normal-tumor whole-genome sequence samples. 61
32940334 2020
19
Systematic profiling of ACE2 expression in diverse physiological and pathological conditions for COVID-19/SARS-CoV-2. 61
32639084 2020
20
Microsatellite instability status differentially associates with intratumoral immune microenvironment in human cancers. 61
32823273 2020
21
Pan‑cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS‑CoV‑2 infection leading to COVID-19. 61
32468052 2020
22
Prognostic significance of immune landscape in tumour microenvironment of endometrial cancer. 61
32424934 2020
23
PTEN mutation: A potential prognostic factor associated with immune infiltration in endometrial carcinoma. 61
32279917 2020
24
A 14-Methylation-Driven Differentially Expressed RNA as a Signature for Overall Survival Prediction in Patients with Uterine Corpus Endometrial Carcinoma. 61
32397815 2020
25
A comprehensive analysis of IDO1 expression with tumour-infiltrating immune cells and mutation burden in gynaecologic and breast cancers. 61
32227579 2020
26
Ancestry-specific predisposing germline variants in cancer. 61
32471518 2020
27
ACE2 correlated with immune infiltration serves as a prognostic biomarker in endometrial carcinoma and renal papillary cell carcinoma: implication for COVID-19. 61
32339157 2020
28
Identification of a Multi-RNA-Type-Based Signature for Recurrence-Free Survival Prediction in Patients with Uterine Corpus Endometrial Carcinoma. 61
32105510 2020
29
Prognostic significance of mutant-allele tumor heterogeneity in uterine corpus endometrial carcinoma. 61
32355783 2020
30
The pan-cancer landscape of netrin family reveals potential oncogenic biomarkers. 61
32251318 2020
31
Bioinformatics Analysis of Global Proteomic and Phosphoproteomic Data Sets Revealed Activation of NEK2 and AURKA in Cancers. 61
32033228 2020
32
Comprehensive bioinformatic analysis of Wnt1 and Wnt1-associated diseases. 61
32201670 2020
33
Cooperative driver pathway discovery via fusion of multi-relational data of genes, miRNAs and pathways. 61
32103253 2020
34
Comprehensive analysis of LDHAP5 pseudogene expression and potential pathogenesis in ovarian serous cystadenocarcinoma. 61
32536817 2020
35
RNF183 Is a Prognostic Biomarker and Correlates With Tumor Purity, Immune Infiltrates in Uterine Corpus Endometrial Carcinoma. 61
33324448 2020
36
Comprehensive analysis of two potential novel SARS-CoV-2 entries, TMPRSS2 and IFITM3, in healthy individuals and cancer patients. 61
33061814 2020
37
Genome and transcriptome profiling of FBXW family in human prostate cancer. 61
32929407 2020
38
Clinical Implications of Aberrant PD-1 and CTLA4 Expression for Cancer Immunity and Prognosis: A Pan-Cancer Study. 61
33072070 2020
39
Multiomics profile and prognostic gene signature of m6A regulators in uterine corpus endometrial carcinoma. 61
33033522 2020
40
An Integrative Computational Approach Based on Expression Similarity Signatures to Identify Protein-Protein Interaction Networks in Female-Specific Cancers. 61
33424936 2020
41
Machine Learning Supports Long Noncoding RNAs as Expression Markers for Endometrial Carcinoma. 61
32420338 2020
42
Triple-high expression of phosphatase and tensin homolog (PTEN), estrogen receptor (ER) and progesterone receptor (PR) may predict favorable prognosis for patients with Type I endometrial carcinoma. 61
32047550 2020
43
Efficient Gaussian sample specific network marker discovery and drug enrichment analysis validation. 61
31751888 2019
44
Identification of hub genes and key pathways associated with the progression of gynecological cancer. 61
31788113 2019
45
A 7-lncRNA signature predict prognosis of Uterine corpus endometrial carcinoma. 61
31168849 2019
46
Construction of a Competitive Endogenous RNA Network in Uterine Corpus Endometrial Carcinoma. 61
31650984 2019
47
A Shallow Convolutional Learning Network for Classification of Cancers Based on Copy Number Variations. 61
31569801 2019
48
Expression of long non-coding RNA ANRIL predicts a poor prognosis in intrahepatic cholangiocarcinoma. 61
31040073 2019
49
Alteration of tumor associated neutrophils by PIK3CA expression in endometrial carcinoma from TCGA data. 61
31472672 2019
50
DNA Methylation Module Network-Based Prognosis and Molecular Typing of Cancer. 61
31357729 2019

Variations for Uterine Corpus Endometrial Carcinoma

Expression for Uterine Corpus Endometrial Carcinoma

Search GEO for disease gene expression data for Uterine Corpus Endometrial Carcinoma.

Pathways for Uterine Corpus Endometrial Carcinoma

Pathways related to Uterine Corpus Endometrial Carcinoma according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.79 TP53 PTEN PPP2R1A PIK3R1 PIK3CA HLA-A
2
Show member pathways
12.63 TP53 PTEN PIK3R1 PIK3CA ARID1A
3
Show member pathways
12.56 TP53 PTEN PPP2R1A PIK3R1 PIK3CA
4
Show member pathways
12.39 TP53 PTEN PIK3R1 PIK3CA
5
Show member pathways
12.37 TP53 PPP2R1A PIK3R1 PIK3CA
6 12.28 U2AF1 TP53 PIK3R1 PIK3CA
7
Show member pathways
12.27 TP53 PTEN PIK3R1 PIK3CA
8
Show member pathways
12.17 TP53 PTEN PIK3R1 PIK3CA
9 12.15 TP53 PIK3R1 PIK3CA HLA-A
10 12.06 TP53 PTEN PIK3R1 PIK3CA HLA-A
11 11.8 PPP2R1A PIK3R1 PIK3CA
12 11.77 TP53 PTEN PIK3R1 PIK3CA
13 11.74 PTEN PIK3R1 PIK3CA
14 11.63 TP53 PTEN PIK3R1 PIK3CA
15 11.62 TP53 PIK3R1 PIK3CA
16
Show member pathways
11.55 TP53 PIK3R1 PIK3CA
17 11.55 TP53 PTEN PIK3R1 PIK3CA HLA-A
18 11.42 PTEN PIK3R1 PIK3CA
19 11.4 TP53 PTEN PIK3CA
20 11.4 TP53 PTEN PIK3R1 PIK3CA
21 11.28 TP53 PTEN PIK3CA ARID1A
22 11.25 PTEN PIK3R1 PIK3CA
23 11.1 TP53 PTEN PPP2R1A PIK3R1 PIK3CA
24 11.09 PTEN PIK3R1 PIK3CA
25 10.75 PIK3R1 PIK3CA

GO Terms for Uterine Corpus Endometrial Carcinoma

Cellular components related to Uterine Corpus Endometrial Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol 3-kinase complex, class IA GO:0005943 8.62 PIK3R1 PIK3CA

Biological processes related to Uterine Corpus Endometrial Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol biosynthetic process GO:0006661 9.13 PTEN PIK3R1 PIK3CA
2 phosphatidylinositol 3-kinase signaling GO:0014065 8.8 PTEN PIK3R1 PIK3CA

Molecular functions related to Uterine Corpus Endometrial Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor substrate binding GO:0043560 8.62 PIK3R1 PIK3CA

Sources for Uterine Corpus Endometrial Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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