MCID: UTR037
MIFTS: 39

Uterine Corpus Sarcoma

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Uterine Corpus Sarcoma

MalaCards integrated aliases for Uterine Corpus Sarcoma:

Name: Uterine Corpus Sarcoma 12 15 70
Sarcoma of the Corpus Uteri 58
Sarcoma of Corpus Uteri 12
Sarcoma of Uterus 12

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

Disease Ontology 12 DOID:5165
NCIt 50 C6339
SNOMED-CT 67 254877001
ICD10 via Orphanet 33 C54.2
UMLS via Orphanet 71 C0338113
Orphanet 58 ORPHA213620
UMLS 70 C0338113

Summaries for Uterine Corpus Sarcoma

Disease Ontology : 12 An uterine corpus cancer that is located in the muscles of the uterus or located in other tissues that support the uterus.

MalaCards based summary : Uterine Corpus Sarcoma, also known as sarcoma of the corpus uteri, is related to carcinosarcoma and leiomyosarcoma. An important gene associated with Uterine Corpus Sarcoma is NTRK1 (Neurotrophic Receptor Tyrosine Kinase 1), and among its related pathways/superpathways are Keratinization and Cytoskeletal Signaling. The drugs Sargramostim and Gemcitabine have been mentioned in the context of this disorder. Affiliated tissues include muscles of the uterus, other tissues and uterus, and related phenotypes are cellular and immune system

Related Diseases for Uterine Corpus Sarcoma

Diseases related to Uterine Corpus Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 411)
# Related Disease Score Top Affiliating Genes
1 carcinosarcoma 30.5 PGR KRT7 KIT
2 leiomyosarcoma 30.5 PGR MYOG MLANA KIT
3 cystic teratoma 30.1 NKX2-1 KRT7 KIT
4 mature teratoma 30.0 TNFRSF8 KRT7 KIT
5 leiomyoma 30.0 PGR KIT CD34
6 spindle cell sarcoma 29.8 MYOG KRT7 KIT CD34 CALD1
7 myoma 29.5 PGR KIT CD34 CALD1 CALCA
8 wilms tumor 1 29.3 PGR NKX2-1 MYOG KRT7 CD34
9 uterus leiomyosarcoma 28.6 TNFRSF8 PGR NTRK1 NKX2-1 MYOG MLANA
10 uterine sarcoma 11.2
11 uterine corpus endometrial stromal sarcoma 11.2
12 uterine carcinosarcoma 11.2
13 urethra leiomyoma 10.4 KIT CALD1
14 small intestinal sarcoma 10.4 NTRK1 KIT
15 cervical adenoid cystic carcinoma 10.4 KRT7 KIT
16 lymphoepithelioma-like thymic carcinoma 10.4 KRT5 KIT
17 gastric leiomyoma 10.4 KIT CALD1
18 cervical mucinous adenocarcinoma 10.4 KRT7 CALD1
19 trachea adenoid cystic carcinoma 10.4 KRT5 KIT
20 ureter squamous cell carcinoma 10.4 KRT7 KRT5
21 sarcoma 10.4
22 inverted transitional papilloma 10.4 KRT7 KRT5
23 ceruminoma 10.4 KRT7 KRT5
24 spindle epithelial tumor with thymus-like differentiation tumor 10.4 KIT CALCA
25 diffuse peritoneal leiomyomatosis 10.4 PGR CALD1
26 lung leiomyoma 10.4 PGR CALD1
27 bartholin's gland adenoid cystic carcinoma 10.4 PGR KRT7
28 lung adenoid cystic carcinoma 10.4 KRT7 KIT
29 adenoid basal cell carcinoma 10.4 KRT7 KIT
30 urethral villous adenoma 10.4 PGR KRT7
31 malignant acrospiroma 10.4 KRT7 KRT5
32 auditory system benign neoplasm 10.4 KRT7 KRT5
33 microinvasive cervical squamous cell carcinoma 10.4 KRT7 KRT5
34 adult cystic nephroma 10.4 PGR KIT
35 cutaneous mucoepidermoid carcinoma 10.4 KRT7 KRT5
36 multiple mucosal neuroma 10.4 NTRK1 CALCA
37 lipid-rich breast carcinoma 10.4 PGR KRT5
38 basaloid lung carcinoma 10.4 PGR KRT5
39 eccrine adenocarcinoma 10.4 KRT7 KRT5
40 oncocytic breast carcinoma 10.4 PGR KRT7
41 bartholin's gland disease 10.4 PGR KRT7
42 lung combined type small cell carcinoma 10.4 MYOG CALD1
43 pineal region teratoma 10.4 MYOG KIT
44 lung clear cell carcinoma 10.4 KRT7 KRT5
45 ovarian seromucinous carcinoma 10.4 PGR KRT7
46 pregnancy adenoma 10.4 PGR KRT5
47 papillary squamous carcinoma 10.4 KRT7 KRT5
48 conventional leiomyosarcoma 10.4 MYOG CALD1
49 necrotizing sialometaplasia 10.4 KRT7 KRT5
50 benign metastasizing leiomyoma 10.4 PGR KRT7

Graphical network of the top 20 diseases related to Uterine Corpus Sarcoma:



Diseases related to Uterine Corpus Sarcoma

Symptoms & Phenotypes for Uterine Corpus Sarcoma

MGI Mouse Phenotypes related to Uterine Corpus Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.96 ALOX5 CD34 CD38 FUT4 KIT KRT19
2 immune system MP:0005387 9.9 ALOX5 CD34 CD38 FUT4 KIT KRT19
3 integument MP:0010771 9.56 CD34 KIT KRT19 KRT5 MLANA MYOG
4 no phenotypic analysis MP:0003012 9.17 KIT KRT19 MLANA MYOG NKX2-1 NTRK1

Drugs & Therapeutics for Uterine Corpus Sarcoma

Drugs for Uterine Corpus Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sargramostim Approved, Investigational Phase 3 123774-72-1, 83869-56-1
2
Gemcitabine Approved Phase 3 95058-81-4 60750
3
Docetaxel Approved, Investigational Phase 3 114977-28-5 148124
4
Bevacizumab Approved, Investigational Phase 3 216974-75-3
5
Lenograstim Approved, Investigational Phase 3 135968-09-1
6 Tubulin Modulators Phase 3
7 Angiogenesis Inhibitors Phase 3
8 Antineoplastic Agents, Immunological Phase 3
9 Adjuvants, Immunologic Phase 3
10 Immunosuppressive Agents Phase 3
11 Antimitotic Agents Phase 3
12 Immunoglobulins Phase 3
13 Mitogens Phase 3
14 Immunoglobulin G Phase 3
15 Immunologic Factors Phase 3
16 Endothelial Growth Factors Phase 3
17 Immunoglobulins, Intravenous Phase 3
18 Anti-Infective Agents Phase 3
19 Antiviral Agents Phase 3
20 Antibodies, Monoclonal Phase 3
21 Antibodies Phase 3
22 Antimetabolites Phase 3
23
Thalidomide Approved, Investigational, Withdrawn Phase 2 50-35-1 5426
24
Molgramostim Investigational Phase 2 99283-10-0
25 Epothilones Phase 2
26 Epothilone B Phase 2
27 Anti-Bacterial Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Phase III Evaluation of Docetaxel (NSC #628503) and Gemcitabine (NSC #613327) Plus G-CSF With Bevacizumab (NSC #704865) Versus Docetaxel (NSC #628503) and Gemcitabine (NSC #613327) Plus G-CSF With Placebo in the Treatment of Recurrent or Advanced Leiomyosarcoma of the Uterus Terminated NCT01012297 Phase 3 Docetaxel;Gemcitabine Hydrochloride
2 A Phase II Evaluation of MLN8237 (NSC# 747888) in the Treatment of Recurrent or Persistent Leiomyosarcoma of the Uterus Completed NCT01637961 Phase 2 Alisertib
3 A Phase II Evaluation of Ixabepilone (NSC #710428) in the Treatment of Recurrent or Persistent Carcinosarcoma of the Uterus Completed NCT01168232 Phase 2 Ixabepilone
4 A Phase II Evaluation of Pazopanib (NSC # 737754) in the Treatment of Recurrent or Persistent Carcinosarcoma of the Uterus Completed NCT01247571 Phase 2 Pazopanib Hydrochloride
5 A Phase II Evaluation of Ixabepilone (NSC #710428) in the Treatment of Recurrent or Persistent Leiomyosarcoma of the Uterus Completed NCT01220609 Phase 2 Ixabepilone
6 A Phase II Evaluation of Thalidomide (NSC #66847) in the Treatment of Recurrent or Persistent Carcinosarcoma of the Uterus Completed NCT00025506 Phase 2 Thalidomide
7 A Phase II Evaluation of Thalidomide (NSC #66847) in the Treatment of Recurrent or Persistent Leiomyosarcoma of the Uterus Completed NCT00025220 Phase 2 Thalidomide
8 A Phase II Evaluation of Gemcitabine (NSC #613327) and Docetaxel (NSC # 628503) in the Treatment of Recurrent or Persistent Carcinosarcoma of the Uterus Completed NCT00114218 Phase 2 Gemcitabine Hydrochloride;Docetaxel
9 A Phase II Evaluation of Docetaxel and Gemcitabine Plus G-CSF in the Treatment of Recurrent or Persistent Leiomyosarcoma of the Uterus Completed NCT00031629 Phase 2 Docetaxel;Gemcitabine Hydrochloride

Search NIH Clinical Center for Uterine Corpus Sarcoma

Genetic Tests for Uterine Corpus Sarcoma

Anatomical Context for Uterine Corpus Sarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Uterine Corpus Sarcoma:

19
Muscles Of The Uterus, Other Tissues

MalaCards organs/tissues related to Uterine Corpus Sarcoma:

40
Uterus, Breast, Lung, Thyroid, Thymus, Skin, Small Intestine

Publications for Uterine Corpus Sarcoma

Articles related to Uterine Corpus Sarcoma:

(show all 21)
# Title Authors PMID Year
1
Ultrasonic and Histopathological Evaluation to Exclude Premalignant and Malignant Lesions in Perimenopausal and Postmenopausal Women Presenting as Abnormal Uterine Bleeding. 61
31686752 2019
2
Metastatic low-grade endometrial stromal sarcoma of uterus presenting as a primary pancreatic tumor: case presentation and literature review. 61
31010432 2019
3
Huge (9 Kg) Broad Ligament Fibroid Mimicking Sarcoma of Uterus: A Case Report and Review of Literature. 61
29307983 2017
4
Genomic landscape of endometrial stromal sarcoma of uterus. 61
26429873 2015
5
[THE SERUM LEVEL OF TOTAL AND OLIGOMERIC FRACTIONS OF SOLUBLE MOLECULES CD38 UNDER MALIGNANT TUMORS OF CERVIX AND UTERINE BODY]. 61
26470437 2015
6
[Coexistence of mediastinal adenopathies of different etiologies -- case report]. 61
23894794 2013
7
Endometrial stromal sarcoma of uterus with metastasis to the lung and brain. 61
22987911 2012
8
Endometrial stromal sarcoma of uterus. 61
21820965 2011
9
Gynecological cancer incidence in a hospital population in Saudi Arabia: the effect of foreign immigration over two decades. 61
18937706 2008
10
[Clinical and pathological analysis of intravenous leiomyomatosis]. 61
15774090 2005
11
Prospective evaluation of FDG-PET for detecting pelvic and para-aortic lymph node metastasis in uterine corpus cancer. 61
15581961 2004
12
[Mast cells in cellular leiomyoma and endometrial stromal sarcoma of the uterus]. 61
15196440 2004
13
[Endometrial stromal sarcoma with multi-differentiation: a study of 17 cases]. 61
11866946 2000
14
Mixed low grade and high grade endometrial stromal sarcoma of uterus: differences on immunohistochemistry and chromosome in situ hybridisation. 61
8813967 1996
15
Stromal cell sarcoma of uterus in a teenaged girl. 61
7890960 1994
16
Stromal sarcoma of uterus; report of two cases. 61
7868184 1994
17
[Hemangiopericytoma (author's transl)]. 61
7269828 1981
18
[A case of small round cell-sarcoma of uterus with dermoid cyst and myoma uteri]. 61
13128134 1953
19
Hodgkin's sarcoma of uterus. 61
20295409 1947
20
Diffuse Round-celled Sarcoma of Uterus and Fallopian Tubes: (Section of Obstetrics and Gynaecology). 61
19989962 1934
21
Diffuse Round-celled Sarcoma of Uterus and Fallopian Tubes: (Section of Obstetrics and Gynæcology). 61
20914359 1934

Variations for Uterine Corpus Sarcoma

Expression for Uterine Corpus Sarcoma

Search GEO for disease gene expression data for Uterine Corpus Sarcoma.

Pathways for Uterine Corpus Sarcoma

Pathways related to Uterine Corpus Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.08 KRT8 KRT7 KRT5 KRT19
2 12.04 KRT8 KRT7 KRT5 KRT19 CALD1
3 11.67 KIT CD38 CD34
4 11.61 TNFRSF8 MLANA KIT CD38 CD34 ALOX5
5 11.58 KIT CD38 CD34
6 11.52 MYOG KIT CD34
7 11.3 KIT CD38 CD34
8
Show member pathways
11.29 KRT8 KRT7 KRT5 KRT19

GO Terms for Uterine Corpus Sarcoma

Cellular components related to Uterine Corpus Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.55 NTRK1 KIT FUT4 CD38 CD34
2 keratin filament GO:0045095 9.43 KRT8 KRT7 KRT5
3 dystrophin-associated glycoprotein complex GO:0016010 9.32 KRT8 KRT19
4 intermediate filament GO:0005882 9.26 KRT8 KRT7 KRT5 KRT19
5 cell periphery GO:0071944 8.92 KRT8 KRT19 FUT4 CD34

Biological processes related to Uterine Corpus Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.56 KRT8 KRT7 KRT5 KRT19
2 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.4 NTRK1 CALCA
3 negative regulation of bone resorption GO:0045779 9.37 CD38 CALCA
4 paracrine signaling GO:0038001 9.32 PGR CD34
5 cell differentiation involved in embryonic placenta development GO:0060706 9.16 KRT8 KRT19
6 response to hydrostatic pressure GO:0051599 8.96 NTRK1 KRT8
7 cornification GO:0070268 8.92 KRT8 KRT7 KRT5 KRT19

Sources for Uterine Corpus Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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