MCID: UTR020
MIFTS: 34

Uterine Inversion

Categories: Reproductive diseases

Aliases & Classifications for Uterine Inversion

MalaCards integrated aliases for Uterine Inversion:

Name: Uterine Inversion 12 44 15 17 72
Inversion of Uterus During Delivery 72

Classifications:



External Ids:

Disease Ontology 12 DOID:997
ICD9CM 35 665.2
MeSH 44 D019687
SNOMED-CT 68 27215002
ICD10 33 N85.5
UMLS 72 C0162482 C0269886

Summaries for Uterine Inversion

Disease Ontology : 12 A uterine disease that is characterized by the uterine cavity turning inside out as a complication of childbirth.

MalaCards based summary : Uterine Inversion, also known as inversion of uterus during delivery, is related to leiomyoma and myoma. An important gene associated with Uterine Inversion is FEZF2 (FEZ Family Zinc Finger 2), and among its related pathways/superpathways are C-MYB transcription factor network and Dendritic Cells Developmental Lineage Pathway. Affiliated tissues include uterus, cervix and placenta, and related phenotypes are growth/size/body region and craniofacial

Wikipedia : 75 Uterine inversion is when the uterus turns inside out, usually following childbirth. Symptoms include... more...

Related Diseases for Uterine Inversion

Diseases related to Uterine Inversion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 leiomyoma 10.4
2 myoma 10.4
3 uterine sarcoma 10.3
4 sarcoma 10.3
5 spindle cell sarcoma 10.3
6 breast metaplastic carcinoma 10.3 FEZF2 FEZF1
7 eyelid carcinoma 10.3 FEZF2 FEZF1
8 acute laryngitis 10.3 FEZF2 FEZF1
9 lymph node tuberculosis 10.2 FEZF2 FEZF1
10 placenta accreta 10.2
11 endometrial cancer 10.1
12 cardiac arrest 10.1
13 vaginal discharge 10.1
14 leiomyosarcoma 10.1
15 rhabdomyosarcoma 10.1
16 leiomyoma, uterine 10.1
17 carcinosarcoma 10.1
18 neurodermatitis 10.1 FEZF2 FEZF1
19 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.0 KIT CSF1R
20 teratoma 10.0
21 core binding factor acute myeloid leukemia 10.0 KIT CSF1R
22 phaeohyphomycosis 10.0 FEZF2 FEZF1
23 pelvic organ prolapse 9.9
24 cervical cancer 9.9
25 adenosarcoma 9.9
26 embryonal rhabdomyosarcoma 9.9
27 infertility 9.9
28 placental abruption 9.9
29 adenosarcoma of the uterus 9.9
30 hypotonia 9.9
31 bicornuate uterus 9.9
32 malignant skin fibrous histiocytoma 9.9 KIT F7
33 neurofibromatosis, type i 9.8 OXT KIT
34 rhabdomyosarcoma 2 9.8
35 fibroma 9.8
36 thrombosis 9.8
37 endometritis 9.8
38 pre-eclampsia 9.8
39 microphthalmia 9.8
40 hydronephrosis 9.8
41 disseminated intravascular coagulation 9.8
42 facial paralysis 9.8
43 adenofibroma 9.8
44 endometriosis 9.8
45 anuria 9.8
46 cervical adenocarcinoma 9.8
47 myofibroma 9.8
48 endometrial squamous cell carcinoma 9.8
49 uterine carcinosarcoma 9.8
50 47,xyy 9.8

Graphical network of the top 20 diseases related to Uterine Inversion:



Diseases related to Uterine Inversion

Symptoms & Phenotypes for Uterine Inversion

MGI Mouse Phenotypes related to Uterine Inversion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.7 CSF1R F7 FEZF1 FEZF2 KIT MIXL1
2 craniofacial MP:0005382 9.65 CSF1R F7 FEZF1 FEZF2 KIT
3 mortality/aging MP:0010768 9.56 CSF1R F7 FEZF1 FEZF2 KIT MIXL1
4 taste/olfaction MP:0005394 8.8 CSF1R FEZF1 FEZF2

Drugs & Therapeutics for Uterine Inversion

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Controlled Cord Traction During Third Stage of Labor: Pilot Trial Completed NCT00781066 Phase 3

Search NIH Clinical Center for Uterine Inversion

Cochrane evidence based reviews: uterine inversion

Genetic Tests for Uterine Inversion

Anatomical Context for Uterine Inversion

MalaCards organs/tissues related to Uterine Inversion:

41
Uterus, Cervix, Placenta, Ovary, Bone, Bone Marrow

Publications for Uterine Inversion

Articles related to Uterine Inversion:

(show top 50) (show all 416)
# Title Authors PMID Year
1
Uterine Inversion as a Result of a Large Prolapsed Carcinosarcoma of the Uterus. 38
30686610 2019
2
A case report of an aggressive rhabdomyosarcoma associated with non-puerperal uterine inversion. 38
31342794 2019
3
Laparoscopic Management of Nonpuerperal Uterine Inversion. 38
30590129 2019
4
Decline in maternal death due to obstetric haemorrhage between 2010 and 2017 in Japan. 38
31363105 2019
5
Non-puerperal uterine inversion associated with adenosarcoma of the uterus: A case report. 38
30923682 2019
6
Uterine Inversion Presenting as Pelvic Organ Prolapse in a Patient with Leiomyosarcoma. 38
30926367 2019
7
An exceptional uterine inversion in a virgo patient affected by submucosal leiomyoma: Case report and review of the literature. 38
30187623 2019
8
Non-puerperal uterine inversion associated with myomatosis. 38
30892434 2019
9
Chronic uterine inversion with malignancy mimicking carcinoma cervix. 38
30709891 2019
10
Total Uterine Inversion Post Partum: Case Report and Management Strategies. 38
31239851 2018
11
Detection of Asherman's syndrome after conservative management of placenta accreta: a case report. 38
30454053 2018
12
U-turn of uterine arteries: a novel sign pathognomonic of uterine inversion. 38
30284197 2018
13
Non Puerperal Uterine Inversion Due to Submucous Myoma: A Case Report. 38
31223323 2018
14
Chronic non-puerperal uterine inversion in an asymptomatic woman. 38
29430980 2018
15
Chronic Uterine Inversion Following Mid-Trimester Abortion. 38
30065549 2018
16
Uterine Inversion: A Review of a Life-Threatening Obstetrical Emergency. 38
30062382 2018
17
Varied Clinical Presentations, the Role of Magnetic Resonance Imaging in the Diagnosis, and Successful Management of Cervical Leiomyomas: A Case-Series and Review of Literature. 38
30034975 2018
18
[Uterine inversion: about a case]. 38
29875980 2018
19
Chronic incomplete non-puerperal uterine inversion due to huge submucous fibroid: diagnosis and management. 38
29378741 2018
20
Risks and consequences of puerperal uterine inversion in the United States, 2004 through 2013. 38
28522320 2017
21
Puerperal uterine inversion from two viewpoints: Its recurrence at the next pregnancy and "unavoidable"-procedure-associated inversion. 38
28495186 2017
22
Postpartum ultrasound: postpartum assessment using ultrasonography. 38
27578054 2017
23
Uterine Adenofibroma: An Unsual Cause of Nonpuerperal Uterine Inversion in Postmenopausal Female. 38
28706412 2017
24
Transcatheter Arterial Embolization for Primary Postpartum Hemorrhage: Predictive Factors of Need for Embolic Material Conversion of Gelatin Sponge Particles to N-Butyl Cyanoacrylate. 38
27812783 2017
25
[Uterine inversion]. 38
28585847 2017
26
A large uterine leiomyoma leading to non-puerperal uterine inversion: A case report. 38
28280801 2017
27
Successful use of a Bakri Tamponade Balloon in the treatment of puerperal uterine inversion during caesarean section. 38
28403951 2017
28
Non-puerperal Uterine Inversion Presented with Hypovolemic Shock. 38
28119900 2016
29
Color Doppler examination for the diagnosis of subacute puerperal uterine inversion. 38
27245667 2016
30
Acute complete uterine inversion after controlled cord traction of placenta following vaginal delivery: a case report. 38
27386133 2016
31
Upside-Down and Inside-Out Signs in Uterine Inversion. 38
27298665 2016
32
Non-puerperal uterine inversion due to submucous myoma in a woman: a case report. 38
28471130 2016
33
Chronic Uterine Inversion Presenting as a Painless Vaginal Mass at 6 Months Post Partum: A Case Report. 38
27437313 2016
34
Non-Puerperal Uterine Inversion. 38
30151455 2016
35
[Acute uterine inversion after delivery]. 38
27897027 2016
36
Uterine inversion after an unskilled delivery - still a concern for maternal mortality: A case report and discussion of the related medico-legal issues. 38
26232213 2016
37
Laparoscopic View of a Case of Incomplete Uterine Inversion After Vaginal Delivery. 38
27679099 2015
38
Chronic total uterine inversion in an adolescent. 38
26576285 2015
39
Chronic Total Uterine Inversion in a Young Adult Patient. 38
26494120 2015
40
Magnetic Resonance Imaging of Non-Puerperal Complete Uterine Inversion. 38
26715983 2015
41
Non-puerperal uterine inversion in a young woman: a case report. 38
27830135 2015
42
Kissing of Ovaries: Laparoscopic View of Uterine Inversion After Vaginal Delivery With Postpartum Hemorrhage. 38
25433278 2015
43
Pulse contour analysis guided management of a case of puerperal uterine inversion and hemorrhagic shock - 'Giving what it takes'. 38
26265875 2015
44
Non-puerperal uterine inversion in a patient with intracranial sigmoid sinus thrombosis and facial palsy. 38
25969481 2015
45
Uterine inversion as an extremely rare cause of secondary infertility: A case report. 38
28913041 2015
46
Cardiac arrest following acute puerperal uterine inversion. 38
25694631 2015
47
Successful reduction of acute puerperal uterine inversion with the use of a bakri postpartum balloon. 38
25954560 2015
48
Intrauterine tamponade balloon use in the treatment of uterine inversion. 38
25564634 2015
49
Puerperal uterine inversion managed by the uterine balloon tamponade. 38
26977239 2015
50
Sonographic diagnosis of complete uterine inversion: an unusual case. 38
26054129 2015

Variations for Uterine Inversion

Expression for Uterine Inversion

Search GEO for disease gene expression data for Uterine Inversion.

Pathways for Uterine Inversion

Pathways related to Uterine Inversion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.15 KIT CSF1R
2 11.02 KIT CSF1R
3 10.68 MIXL1 KIT
4 10.3 KIT CSF1R

GO Terms for Uterine Inversion

Biological processes related to Uterine Inversion according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.83 MIXL1 FEZF2 FEZF1 CSF1R
2 negative regulation of cell proliferation GO:0008285 9.71 FEZF2 FEZF1 CSF1R
3 positive regulation of cell migration GO:0030335 9.61 KIT F7 CSF1R
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.51 KIT CSF1R
5 forebrain development GO:0030900 9.49 FEZF2 FEZF1
6 regulation of neurogenesis GO:0050767 9.48 FEZF2 FEZF1
7 digestive tract development GO:0048565 9.46 MIXL1 KIT
8 cell differentiation GO:0030154 9.43 MIXL1 FEZF2 FEZF1
9 telencephalon development GO:0021537 9.4 FEZF2 FEZF1
10 axon guidance GO:0007411 9.37 FEZF1 CSF1R
11 hemopoiesis GO:0030097 9.33 MIXL1 KIT CSF1R
12 olfactory bulb development GO:0021772 9.32 FEZF1 CSF1R
13 cell dedifferentiation GO:0043697 8.96 FEZF2 FEZF1
14 forebrain anterior/posterior pattern specification GO:0021797 8.62 FEZF2 FEZF1

Molecular functions related to Uterine Inversion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.33 MIXL1 FEZF2 FEZF1
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.96 KIT CSF1R
3 cytokine binding GO:0019955 8.62 KIT CSF1R

Sources for Uterine Inversion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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