Uterus Carcinoma in Situ disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Uterus Carcinoma in Situ

MalaCards integrated aliases for Uterus Carcinoma in Situ:

Name: Uterus Carcinoma in Situ ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:9108

ICD9CM ³⁵ 233.2

UMLS ⁷³ C0154086

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Summaries for Uterus Carcinoma in Situ

Disease Ontology : ¹² An in situ carcinoma that is located in the uterus.

MalaCards based summary : Uterus Carcinoma in Situ is related to cervicitis and chronic cervicitis. An important gene associated with Uterus Carcinoma in Situ is SERPIND1 (Serpin Family D Member 1), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Oncogene Induced Senescence. Affiliated tissues include uterus, lung and skin, and related phenotype is mortality/aging.

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Related Diseases for Uterus Carcinoma in Situ

Diseases related to Uterus Carcinoma in Situ via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)

#	Related Disease	Score	Top Affiliating Genes
1	cervicitis	10.2	CDKN2A SERPIND1
2	chronic cervicitis	10.2	GP6 SERPIND1
3	balanoposthitis	10.2	CDKN2A GP6
4	bladder squamous cell carcinoma	10.2	CDKN2A TP53
5	keratinizing squamous cell carcinoma	10.2	CDKN2A TP53
6	spitz nevus	10.2	CDKN2A TP53
7	bladder carcinoma in situ	10.2	CDKN2A TP53
8	scrotal carcinoma	10.2	CDKN2A TP53
9	nasal cavity adenocarcinoma	10.2	CDKN2A TP53
10	bartholin's gland disease	10.2	CDKN2A TP53
11	anal squamous cell carcinoma	10.2	CDKN2A TP53
12	megaesophagus	10.2	CDKN2A TP53
13	glycogen-rich clear cell breast carcinoma	10.2	CDKN2A TP53
14	gastric adenosquamous carcinoma	10.2	CDKN2A TP53
15	oral leukoplakia	10.2	CDKN2A TP53
16	meningeal melanomatosis	10.2	CDKN2A TP53
17	suppressor of tumorigenicity 3	10.2	CDKN2A TP53
18	dedifferentiated liposarcoma	10.2	CDKN2A TP53
19	endocervical adenocarcinoma	10.2	CDKN2A TP53
20	cervix small cell carcinoma	10.2	CDKN2A TP53
21	necrotizing sialometaplasia	10.2	CDKN2A TP53
22	verrucous carcinoma	10.2	CDKN2A TP53
23	tongue disease	10.2	CDKN2A TP53
24	biliary tract neoplasm	10.2	CDKN2A TP53
25	optic nerve neoplasm	10.2	CDKN2A TP53
26	juvenile pilocytic astrocytoma	10.2	CDKN2A TP53
27	tonsil cancer	10.2	CDKN2A TP53
28	eccrine sweat gland neoplasm	10.2	KRT17 TP53
29	recessive dystrophic epidermolysis bullosa	10.1	CDKN2A TP53
30	cervical adenosarcoma	10.1	GP5 GP6
31	vulva cancer	10.1	CDKN2A TP53
32	squamous cell papilloma	10.1	CDKN2A TP53
33	barrett's adenocarcinoma	10.1	CDKN2A TP53
34	ampulla of vater cancer	10.1	KRT17 TP53
35	herpangina	10.1	GP5 GP6
36	oropharynx cancer	10.1	CDKN2A TP53
37	anus disease	10.1	CDKN2A GP5
38	cervix carcinoma	10.1	CDKN2A TP53
39	laryngeal disease	10.1	CDKN2A SERPIND1 TP53
40	pancreatic ductal carcinoma	10.1	CDKN2A TP53
41	rectal disease	10.1	CDKN2A GP5
42	skin squamous cell carcinoma	10.1	CDKN2A TP53
43	anogenital venereal wart	10.1	CDKN2A GP6 TP53
44	penile disease	10.1	CDKN2A GP6 TP53
45	vulva squamous cell carcinoma	10.1	CDKN2A KRT17 TP53
46	basaloid squamous cell carcinoma	10.1	CDKN2A KRT17 TP53
47	inverted papilloma	10.1	CDKN2A TP53
48	actinic keratosis	10.1	CDKN2A KRT17 TP53
49	early invasive cervical adenocarcinoma	10.0	CDKN2A INSM1
50	fallopian tube endometrioid adenocarcinoma	10.0	CDKN2A INSM1

Graphical network of the top 20 diseases related to Uterus Carcinoma in Situ:

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Symptoms & Phenotypes for Uterus Carcinoma in Situ

MGI Mouse Phenotypes related to Uterus Carcinoma in Situ:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	mortality/aging	MP:0010768	9.28	CDKN2A CINP COL27A1 GP6 INSM1 KLHL40

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Drugs & Therapeutics for Uterus Carcinoma in Situ

Search Clinical Trials , NIH Clinical Center for Uterus Carcinoma in Situ

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Genetic Tests for Uterus Carcinoma in Situ

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Anatomical Context for Uterus Carcinoma in Situ

MalaCards organs/tissues related to Uterus Carcinoma in Situ:

⁴¹

Uterus, Lung, Skin, Tongue, Tonsil, Cervix, Thyroid

The Foundational Model of Anatomy Ontology organs/tissues related to Uterus Carcinoma in Situ:

¹⁹

The Uterus

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Publications for Uterus Carcinoma in Situ

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Genes for Uterus Carcinoma in Situ

Genes related to Uterus Carcinoma in Situ (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SERPIND1	Serpin Family D Member 1	Protein Coding	17.11	DISEASES inferred ¹⁵
2	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	16	DISEASES inferred ¹⁵
3	KRT80	Keratin 80	Protein Coding	15.91	DISEASES inferred ¹⁵
4	GP6	Glycoprotein VI Platelet	Protein Coding	15.68	DISEASES inferred ¹⁵
5	KRT17	Keratin 17	Protein Coding	15.47	DISEASES inferred ¹⁵
6	COL27A1	Collagen Type XXVII Alpha 1 Chain	Protein Coding	15.26	DISEASES inferred ¹⁵
7	TP53	Tumor Protein P53	Protein Coding	15.03	DISEASES inferred ¹⁵
8	MTMR12	Myotubularin Related Protein 12	Protein Coding	14.84	DISEASES inferred ¹⁵
9	CINP	Cyclin Dependent Kinase 2 Interacting Protein	Protein Coding	14.73	DISEASES inferred ¹⁵
10	KLHL40	Kelch Like Family Member 40	Protein Coding	14.71	DISEASES inferred ¹⁵
11	INSM1	INSM Transcriptional Repressor 1	Protein Coding	6.54	DISEASES inferred ¹⁵
12	GP5	Glycoprotein V Platelet	Protein Coding	5.69	DISEASES inferred ¹⁵

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Variations for Uterus Carcinoma in Situ

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Expression for Uterus Carcinoma in Situ

Search GEO for disease gene expression data for Uterus Carcinoma in Situ.

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Pathways for Uterus Carcinoma in Situ

Pathways related to Uterus Carcinoma in Situ according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Formation of Fibrin Clot (Clotting Cascade) ⁶⁶ Show member pathways Blood Clotting Cascade ¹ Blood Coagulation Signaling Pathways ⁶⁵ Common Pathway of Fibrin Clot Formation ⁶⁶ Extrinsic Pathway of Fibrin Clot Formation ⁶⁶ Extrinsic Prothrombin Activation Pathway ⁶⁴ Intrinsic Pathway of Fibrin Clot Formation ⁶⁶	11.63	GP5 GP6 SERPIND1
2	Oncogene Induced Senescence ⁶⁶	10.83	CDKN2A TP53
3	Inhibition of Ribosome Biogenesis by p14(ARF) ⁶⁴	10.5	CDKN2A TP53
4	TP53 Network ¹ Show member pathways Activation, translocation and oligomerization of BAX ⁶⁶	10.3	CDKN2A TP53
5	Platelet Adhesion to exposed collagen ⁶⁶	9.74	GP5 GP6

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GO Terms for Uterus Carcinoma in Situ

Biological processes related to Uterus Carcinoma in Situ according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell cycle	GO:0007049	9.62	CDKN2A CINP INSM1 TP53
2	blood coagulation	GO:0007596	9.43	GP5 GP6 SERPIND1
3	positive regulation of cell cycle arrest	GO:0071158	9.16	INSM1 TP53
4	replicative senescence	GO:0090399	8.96	CDKN2A TP53
5	hemostasis	GO:0007599	8.8	GP5 GP6 SERPIND1

Molecular functions related to Uterus Carcinoma in Situ according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	disordered domain specific binding	GO:0097718	8.62	CDKN2A TP53

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