Uterus Carcinoma in Situ disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Uterus Carcinoma in Situ

MalaCards integrated aliases for Uterus Carcinoma in Situ:

Name: Uterus Carcinoma in Situ ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:9108

ICD9CM ³⁴ 233.2

SNOMED-CT ⁶⁷ 189342001

UMLS ⁷⁰ C0154086

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Summaries for Uterus Carcinoma in Situ

Disease Ontology : ¹² An in situ carcinoma that is located in the uterus.

MalaCards based summary : Uterus Carcinoma in Situ is related to cervix uteri carcinoma in situ and early invasive cervical adenocarcinoma. An important gene associated with Uterus Carcinoma in Situ is MIR548B (MicroRNA 548b), and among its related pathways/superpathways are Glioblastoma Multiforme and Senescence and Autophagy in Cancer. Affiliated tissues include uterus.

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Related Diseases for Uterus Carcinoma in Situ

Diseases related to Uterus Carcinoma in Situ via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)

#	Related Disease	Score	Top Affiliating Genes
1	cervix uteri carcinoma in situ	27.4	TP53 SERPIND1 RUBCNL RB1 PTPRN MIR654
2	early invasive cervical adenocarcinoma	10.4	INSM1 CDKN2A
3	papillary squamous carcinoma	10.3	INSM1 CDKN2A
4	vulvar intraepithelial neoplasia	10.3	TP53 CDKN2A
5	esophagus verrucous carcinoma	10.3	TP53 CDKN2A
6	ovarian seromucinous carcinoma	10.3	TP53 CDKN2A
7	spitz nevus	10.3	TP53 CDKN2A
8	focal epithelial hyperplasia	10.3	GP6 GP5
9	bizarre leiomyoma	10.3	TP53 CDKN2A
10	basosquamous carcinoma	10.3	TP53 KRT17
11	adult malignant schwannoma	10.3	TP53 CDKN2A
12	comedo carcinoma	10.3	TP53 LCOR GP5
13	supraglottis cancer	10.3	TP53 CDKN2A
14	large cell acanthoma	10.3	TP53 KRT17
15	localized osteosarcoma	10.3	TP53 CDKN2A
16	malignant exocrine pancreas neoplasm	10.3	TP53 CDKN2A
17	thyroid lymphoma	10.2	TP53 CDKN2A
18	squamous cell papilloma	10.2	TP53 GP5 CDKN2A
19	penile benign neoplasm	10.2	TP53 GP5 CDKN2A
20	bladder clear cell adenocarcinoma	10.2	TP53 CDKN2A
21	vulva squamous cell carcinoma	10.2	TP53 GP5 CDKN2A
22	vulvar disease	10.2	TP53 GP5 CDKN2A
23	tonsil cancer	10.2	TP53 MIR338 CDKN2A
24	cervical adenosarcoma	10.2	TP53 GP6 GP5
25	inverted follicular keratosis	10.2	KRT17 GP6 GP5
26	penis squamous cell carcinoma	10.2	TP53 GP6 GP5
27	endocervical carcinoma	10.2	TP53 INSM1 CDKN2A
28	endocervical adenocarcinoma	10.2	TP53 INSM1 CDKN2A
29	soft palate cancer	10.2	GP6 CDKN2A
30	keratosis	10.2	TP53 KRT17 CDKN2A
31	urinary bladder inverted papilloma	10.2	RB1 CDKN2A
32	vulva cancer	10.2	TP53 GP5 CDKN2A
33	herpangina	10.2	TP53 GP6 GP5
34	clear cell basal cell carcinoma	10.2	TP53 KRT17
35	borst-jadassohn intraepidermal carcinoma	10.2	TP53 KRT17 CDKN2A
36	acanthoma	10.2	TP53 KRT17 CDKN2A
37	vulvar dystrophy	10.2	TP53 KRT17 CDKN2A
38	vulvar adenocarcinoma	10.2	TP53 RB1
39	keratinizing squamous cell carcinoma	10.2	TP53 CDKN2A
40	peritoneal serous adenocarcinoma	10.2	TP53 KRT17
41	basaloid squamous cell carcinoma	10.2	TP53 KRT17 CDKN2A
42	small cell carcinoma	10.2	TP53 INSM1 CDKN2A
43	keratosis, seborrheic	10.2	TP53 KRT17 CDKN2A
44	epidermodysplasia verruciformis 1	10.2	TP53 GP6 GP5
45	male reproductive organ benign neoplasm	10.2	TP53 CDKN2A
46	actinic keratosis	10.2	TP53 KRT17 CDKN2A
47	cervical squamous cell carcinoma	10.2	TP53 KRT17 CDKN2A
48	human papillomavirus infectious disease	10.2	TP53 FHIT CDKN2A
49	gallbladder adenoma	10.2	RB1 CDKN2A
50	megaesophagus	10.1	TP53 FHIT CDKN2A

Graphical network of the top 20 diseases related to Uterus Carcinoma in Situ:

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Symptoms & Phenotypes for Uterus Carcinoma in Situ

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Drugs & Therapeutics for Uterus Carcinoma in Situ

Search Clinical Trials , NIH Clinical Center for Uterus Carcinoma in Situ

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Genetic Tests for Uterus Carcinoma in Situ

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Anatomical Context for Uterus Carcinoma in Situ

The Foundational Model of Anatomy Ontology organs/tissues related to Uterus Carcinoma in Situ:

¹⁹

Uterus

MalaCards organs/tissues related to Uterus Carcinoma in Situ:

⁴⁰

Uterus

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Publications for Uterus Carcinoma in Situ

Articles related to Uterus Carcinoma in Situ:

#	Title	Authors	PMID	Year
1	[A resected case of triple cancer in the uterus, lung and thyroid]. ⁶¹	Arimura T...Shimazu H	2681446	1989

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Genes for Uterus Carcinoma in Situ

Genes related to Uterus Carcinoma in Situ (0 elite genes):

(show all 21)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MIR548B	MicroRNA 548b	RNA Gene	9.69	DISEASES inferred ¹⁵ ¹⁵
2	MIR654	MicroRNA 654	RNA Gene	9.02	DISEASES inferred ¹⁵ ¹⁵
3	LCOR	Ligand Dependent Nuclear Receptor Corepressor	Protein Coding	8.37	DISEASES inferred ¹⁵ ¹⁵
4	MIR338	MicroRNA 338	RNA Gene	7.41	DISEASES inferred ¹⁵ ¹⁵
5	SERPIND1	Serpin Family D Member 1	Protein Coding	7.34	DISEASES inferred ¹⁵
6	INSM1	INSM Transcriptional Repressor 1	Protein Coding	6.8	DISEASES inferred ¹⁵
7	GP5	Glycoprotein V Platelet	Protein Coding	6.8	DISEASES inferred ¹⁵
8	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	6.51	DISEASES inferred ¹⁵
9	GP6	Glycoprotein VI Platelet	Protein Coding	6.31	DISEASES inferred ¹⁵
10	TP53	Tumor Protein P53	Protein Coding	6.12	DISEASES inferred ¹⁵
11	KRT17	Keratin 17	Protein Coding	5.98	DISEASES inferred ¹⁵
12	MAL	Mal, T Cell Differentiation Protein	Protein Coding	5.9	DISEASES inferred ¹⁵
13	MIR518E	MicroRNA 518e	RNA Gene	5.9	DISEASES inferred ¹⁵
14	RUBCNL	Rubicon Like Autophagy Enhancer	Protein Coding	5.7	DISEASES inferred ¹⁵
15	FHIT	Fragile Histidine Triad Diadenosine Triphosphatase	Protein Coding	5.64	DISEASES inferred ¹⁵
16	LGALS7B	Galectin 7B	Protein Coding	5.6	DISEASES inferred ¹⁵
17	LGALS7	Galectin 7	Protein Coding	5.6	DISEASES inferred ¹⁵
18	RB1	RB Transcriptional Corepressor 1	Protein Coding	5.49	DISEASES inferred ¹⁵
19	PTPRN	Protein Tyrosine Phosphatase Receptor Type N	Protein Coding	5.34	DISEASES inferred ¹⁵
20	ACP7	Acid Phosphatase 7, Tartrate Resistant (Putative)	Protein Coding	5.34	DISEASES inferred ¹⁵
21	NOL7	Nucleolar Protein 7	Protein Coding	5.32	DISEASES inferred ¹⁵

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Variations for Uterus Carcinoma in Situ

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Expression for Uterus Carcinoma in Situ

Search GEO for disease gene expression data for Uterus Carcinoma in Situ.

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Pathways for Uterus Carcinoma in Situ

Pathways related to Uterus Carcinoma in Situ according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Glioblastoma Multiforme ⁶³	11.63	TP53 RB1 CDKN2A
2	Senescence and Autophagy in Cancer ¹	11.57	TP53 RB1 CDKN2A
3	Small cell lung cancer ³⁶	11.46	TP53 RB1 FHIT
4	Bladder cancer ³⁶ ¹	11.2	TP53 RB1 CDKN2A
5	Photodynamic therapy-induced AP-1 survival signaling. ¹	10.84	TP53 RB1 CDKN2A
6	Platelet Adhesion to exposed collagen ⁶⁵	10.37	GP6 GP5
7	Inhibition of Ribosome Biogenesis by p14(ARF) ⁶³	10.14	TP53 RB1 CDKN2A

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GO Terms for Uterus Carcinoma in Situ

Biological processes related to Uterus Carcinoma in Situ according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Ras protein signal transduction	GO:0007265	9.43	TP53 RB1 CDKN2A
2	replicative senescence	GO:0090399	9.37	TP53 CDKN2A
3	hemostasis	GO:0007599	9.33	SERPIND1 GP6 GP5
4	negative regulation of CD4-positive, alpha-beta T cell proliferation	GO:2000562	9.32	LGALS7B LGALS7
5	apoptotic process	GO:0006915	9.17	TP53 RB1 MAL LGALS7B LGALS7 FHIT
6	positive regulation of cell cycle arrest	GO:0071158	9.13	TP53 INSM1 CDKN2A

Molecular functions related to Uterus Carcinoma in Situ according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	histone deacetylase binding	GO:0042826	9.43	TP53 LCOR INSM1
2	MDM2/MDM4 family protein binding	GO:0097371	9.16	TP53 CDKN2A
3	galactoside binding	GO:0016936	8.96	LGALS7B LGALS7
4	disordered domain specific binding	GO:0097718	8.8	TP53 RB1 CDKN2A

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Sources for Uterus Carcinoma in Situ

¹ BioSystems

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⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

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⁶¹ PubMed

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⁶⁷ SNOMED-CT

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⁶⁹ Tocris

⁷⁰ UMLS

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⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia