MCID: UTR042
MIFTS: 34

Uterus Leiomyosarcoma

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Uterus Leiomyosarcoma

MalaCards integrated aliases for Uterus Leiomyosarcoma:

Name: Uterus Leiomyosarcoma 12 15
Leiomyosarcoma of the Corpus Uteri 58
Leiomyosarcoma of Corpus Uteri 12
Leiomyosarcoma of Uterus 70

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

Disease Ontology 12 DOID:5289
NCIt 50 C6340
SNOMED-CT 67 447389009
ICD10 via Orphanet 33 C54.2
UMLS via Orphanet 71 C0280631
Orphanet 58 ORPHA213625
UMLS 70 C0280631

Summaries for Uterus Leiomyosarcoma

Disease Ontology : 12 A uterine Corpus sarcoma and leiomyosarcoma and uterine Corpus smooth muscle neoplasm that is located in the smooth muscle of the uterus.

MalaCards based summary : Uterus Leiomyosarcoma, also known as leiomyosarcoma of the corpus uteri, is related to leiomyosarcoma and uterine corpus epithelioid leiomyosarcoma. An important gene associated with Uterus Leiomyosarcoma is NTRK1 (Neurotrophic Receptor Tyrosine Kinase 1), and among its related pathways/superpathways are Neuroscience and Keratinization. The drugs Trabectedin and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle of the uterus, uterus and breast, and related phenotype is no phenotypic analysis.

Related Diseases for Uterus Leiomyosarcoma

Diseases related to Uterus Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 444)
# Related Disease Score Top Affiliating Genes
1 leiomyosarcoma 29.9 PGR MYOG MLANA KIT ENO2
2 uterine corpus epithelioid leiomyosarcoma 11.1
3 urethra leiomyoma 10.4 KIT CALD1
4 lymphoepithelioma-like thymic carcinoma 10.4 KRT5 KIT
5 deep leiomyoma 10.4 KIT CALD1
6 trachea adenoid cystic carcinoma 10.4 KRT5 KIT
7 small intestinal sarcoma 10.4 NTRK1 KIT
8 gastric leiomyoma 10.4 KIT CALD1
9 cervical adenoid cystic carcinoma 10.4 KRT7 KIT
10 ureter squamous cell carcinoma 10.4 KRT7 KRT5
11 inverted transitional papilloma 10.4 KRT7 KRT5
12 cervical mucinous adenocarcinoma 10.4 KRT7 CALD1
13 ceruminoma 10.4 KRT7 KRT5
14 liver fibroma 10.4 KRT5 KIT
15 malignant acrospiroma 10.4 KRT7 KRT5
16 microinvasive cervical squamous cell carcinoma 10.4 KRT7 KRT5
17 cutaneous mucoepidermoid carcinoma 10.4 KRT7 KRT5
18 lung adenoid cystic carcinoma 10.4 KRT7 KIT
19 adenoid basal cell carcinoma 10.4 KRT7 KIT
20 lung combined type small cell carcinoma 10.4 MYOG CALD1
21 eccrine adenocarcinoma 10.4 KRT7 KRT5
22 retroperitoneal leiomyosarcoma 10.4 KIT CALD1
23 conventional leiomyosarcoma 10.4 MYOG CALD1
24 lung clear cell carcinoma 10.4 KRT7 KRT5
25 papillary squamous carcinoma 10.4 KRT7 KRT5
26 necrotizing sialometaplasia 10.4 KRT7 KRT5
27 testicular fibroma 10.4 KRT5 CALD1
28 neurogenic arthropathy 10.4 NTRK1 CALCA
29 malignant syringoma 10.4 KRT7 KRT5
30 gastric squamous cell carcinoma 10.4 KRT7 KRT5
31 bile duct mucoepidermoid carcinoma 10.4 KRT7 KRT5
32 inflammatory leiomyosarcoma 10.4 MYOG CALD1
33 endolymphatic sac tumor 10.4 KRT8 KRT7
34 vulvar leiomyosarcoma 10.4 MLANA CALD1
35 ovarian melanoma 10.4 MLANA CALD1
36 adult fibrosarcoma 10.3 MYOG CALD1
37 malignant anus melanoma 10.3 MLANA KIT
38 anal canal paget's disease 10.3 MLANA KRT7
39 anal paget's disease 10.3 MLANA KRT7
40 glomangiosarcoma 10.3 MLANA CALD1
41 mucocele of appendix 10.3 PGR KIT
42 pulmonary vein leiomyosarcoma 10.3 PGR CALD1
43 heart sarcoma 10.3 MYOG KIT
44 malignant dermis tumor 10.3 MLANA KIT
45 synovium neoplasm 10.3 KRT8 KRT7
46 diffuse peritoneal leiomyomatosis 10.3 PGR CALD1
47 lung leiomyoma 10.3 PGR CALD1
48 clear cell hidradenoma 10.3 KRT7 KRT5
49 melanoacanthoma 10.3 MLANA KRT7
50 malignant skin fibrous histiocytoma 10.3 MLANA KIT

Graphical network of the top 20 diseases related to Uterus Leiomyosarcoma:



Diseases related to Uterus Leiomyosarcoma

Symptoms & Phenotypes for Uterus Leiomyosarcoma

MGI Mouse Phenotypes related to Uterus Leiomyosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.17 KIT KRT19 MLANA MYOG NKX2-1 NTRK1

Drugs & Therapeutics for Uterus Leiomyosarcoma

Drugs for Uterus Leiomyosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Trabectedin Approved, Investigational Phase 2 114899-77-3 108150
2
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
3
Liposomal doxorubicin Phase 2 31703
4 Antibiotics, Antitubercular Phase 2
5 Anti-Bacterial Agents Phase 2
6 Alkylating Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multicentric Phase II Trial Studying Efficacy of Doxorubicin Associated With Trabectedin (Yondelis) in First Line Treatment on Patients With Metastatic Leiomyosarcoma (Uterus or Soft Tissue) and/or Inoperable Relapse Completed NCT02131480 Phase 2 Doxorubicin;Trabectedin

Search NIH Clinical Center for Uterus Leiomyosarcoma

Genetic Tests for Uterus Leiomyosarcoma

Anatomical Context for Uterus Leiomyosarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Uterus Leiomyosarcoma:

19
Smooth Muscle Of The Uterus

MalaCards organs/tissues related to Uterus Leiomyosarcoma:

40
Uterus, Breast, Smooth Muscle, Thyroid, Lung, Thymus, Skin

Publications for Uterus Leiomyosarcoma

Articles related to Uterus Leiomyosarcoma:

(show all 16)
# Title Authors PMID Year
1
Repeated cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with recurrent peritoneal carcinomatosis. 61
26912149 2016
2
Uterine leiomyosarcoma: A case report. 61
25540573 2014
3
Epithelioid leiomyosarcoma of uterus. 61
22602833 2012
4
Genital tract malignancies in postmenopausal women. 61
22338412 2010
5
Clinicopathologic features of two rare cases of mesenchymal metastatic tumors in the pancreas: review of the literature. 61
17003653 2006
6
Triple simultaneous primary gynecological malignancies in a 56-year-old patient. 61
17009998 2006
7
Leiomyosarcoma of uterus--a case report. 61
16910338 2006
8
Peritoneal washing cytology findings of disseminated myxoid leiomyosarcoma of uterus: report of a case with emphasis on possible differential diagnosis. 61
12112816 2002
9
[Metastasis in submandibular gland from a leiomyosarcoma of the uterus]. 61
11998523 2002
10
Reduced expression of calponin h1 in leiomyosarcoma of the uterus. 61
9690561 1998
11
Leiomyosarcoma of the uterus metastatic to brain: a case report and a review of the literature. 61
8063254 1994
12
[Diagnostic errors in dysfunctional uterine bleeding. Analysis of 24 cases]. 61
1291214 1992
13
Leiomyosarcoma of uterus: a review of 14 cases. 61
2819573 1989
14
The epidemiology of sarcomas of the uterus. 61
3456457 1986
15
[The comparative study of renogram both in case of dehydration and hydration (author's transl)]. 61
7384571 1980
16
Leiomyosarcoma of uterus following irradiation for non malignant bleeding. 61
13083000 1953

Variations for Uterus Leiomyosarcoma

Expression for Uterus Leiomyosarcoma

Search GEO for disease gene expression data for Uterus Leiomyosarcoma.

Pathways for Uterus Leiomyosarcoma

Pathways related to Uterus Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.09 NTRK1 NKX2-1 ENO2 CALCA
2
Show member pathways
11.91 KRT8 KRT7 KRT5 KRT19
3 11.84 KRT8 KRT7 KRT5 KRT19 CALD1
4
Show member pathways
10.96 KRT8 KRT7 KRT5 KRT19

GO Terms for Uterus Leiomyosarcoma

Cellular components related to Uterus Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 9.33 KRT8 KRT7 KRT5
2 costamere GO:0043034 9.32 KRT8 KRT19
3 dystrophin-associated glycoprotein complex GO:0016010 9.26 KRT8 KRT19
4 cell periphery GO:0071944 9.13 KRT8 KRT19 FUT4
5 intermediate filament GO:0005882 8.92 KRT8 KRT7 KRT5 KRT19

Biological processes related to Uterus Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.46 KRT8 KRT7 KRT5 KRT19
2 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.32 NTRK1 CALCA
3 cell differentiation involved in embryonic placenta development GO:0060706 9.26 KRT8 KRT19
4 response to hydrostatic pressure GO:0051599 8.96 NTRK1 KRT8
5 cornification GO:0070268 8.92 KRT8 KRT7 KRT5 KRT19

Sources for Uterus Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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