MCID: UVL010
MIFTS: 39

Uveal Disease

Categories: Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Uveal Disease

MalaCards integrated aliases for Uveal Disease:

Name: Uveal Disease 12 15
Uveal Diseases 73 20 44 70

Classifications:



External Ids:

Disease Ontology 12 DOID:3480
MeSH 44 D014603
NCIt 50 C26908
SNOMED-CT 67 95678007
UMLS 70 C0042161

Summaries for Uveal Disease

Disease Ontology : 12 An eye disease affecting the uvea, which are the pigmented layers of the eye consisting of the iris, ciliary body, and choroid.

MalaCards based summary : Uveal Disease, also known as uveal diseases, is related to uveitis and allergic disease, and has symptoms including mydriasis and eye manifestations. An important gene associated with Uveal Disease is CRYAA (Crystallin Alpha A), and among its related pathways/superpathways are Allograft rejection and Yersinia infection. The drugs Methotrexate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotypes are integument and respiratory system

Wikipedia : 73 The uvea (/ˈjuːviə/; Lat. uva, "grape"), also called the uveal layer, uveal coat, uveal tract, vascular... more...

Related Diseases for Uveal Disease

Diseases related to Uveal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 519)
# Related Disease Score Top Affiliating Genes
1 uveitis 32.1 TNF SAG RBP3 IL6 IL17A CRYAA
2 allergic disease 30.6 TNF IL6 ICOSLG CCR6
3 intraocular pressure quantitative trait locus 30.4 SERPINA3 PAX6 LOXL1 CRYAA
4 eye disease 29.7 U2AF1 TNF SERPINA3 SAG RBP3 PAX6
5 phakomatosis cesioflammea 10.6 GNAQ GNA11
6 external pathological resorption 10.6 TNF IL6
7 legume allergy 10.5 ICOSLG CD4 CCR6
8 fruit allergy 10.5 ICOSLG CD4 CCR6
9 optic papillitis 10.5 SAG RBP3 CD4
10 immunodeficiency 16 10.5 ICOSLG CD4 CCR6
11 scorpion envenomation 10.5 TNF IL6
12 physiological polycythemia 10.5 TNF IL6
13 autoimmune glomerulonephritis 10.5 ICOSLG CD4 CCR6
14 ophthalmomyiasis 10.5 SAG RBP3 CD4
15 meningeal melanoma 10.5 GNAQ GNA11
16 primary thrombocytopenia 10.5 ICOSLG CD4 CCR6
17 meningeal melanomatosis 10.5 GNAQ GNA11
18 malignant leptomeningeal tumor 10.5 GNAQ GNA11
19 esophageal candidiasis 10.5 IL17A CD4 CCR6
20 anogenital venereal wart 10.5 H2AC18 CD4 CCR6
21 pustulosis of palm and sole 10.5 TNF IL17A CCR6
22 subcutaneous mycosis 10.5 IL17A CD4 CCR6
23 mucocutaneous leishmaniasis 10.5 TNF H2AC18 CD4
24 lens subluxation 10.5 PAX6 LOXL1 CRYAA
25 birdshot chorioretinopathy 10.5 RBP3 IL17A CCR6
26 tuberculoid leprosy 10.5 TNF CD4 CCR6
27 spondyloarthropathy 10.5 TNF IL6 IL17A
28 immune-complex glomerulonephritis 10.5 ICOSLG H2AC18 CD4
29 autoimmune cholangitis 10.5 IL17A CD4 CCR6
30 immunoglobulin alpha deficiency 10.5 ICOSLG CD4 CCR6
31 malignant spindle cell melanoma 10.5 SERPINA3 GNAQ GNA11
32 dermatophytosis 10.5 IL17A CD4 CCR6
33 coccidioidomycosis 10.5 IL17A CD4 CCR6
34 anemia, autoimmune hemolytic 10.5 ICOSLG CD4 CCR6
35 goodpasture syndrome 10.5 H2AC18 CD4 CCR6
36 syndromic microphthalmia 10.5 PAX6 H2AC18 CRYAA
37 dental pulp disease 10.5 TNF IL6 CCR6
38 juvenile glaucoma 10.5 PAX6 LOXL1 CRYAA
39 phacogenic glaucoma 10.5 SERPINA3 LOXL1 CRYAA
40 meningovascular neurosyphilis 10.5 TNF IL17A CD4
41 parasitic ectoparasitic infectious disease 10.5 H2AC18 CD4 CCR6
42 nasopharyngitis 10.5 TNF IL17A CCR6
43 meningeal melanocytoma 10.5 GNAQ GNA11
44 central nervous system hematologic cancer 10.5 MIR199A1 CD4 CCR6
45 respiratory allergy 10.5 ICOSLG CD4 CCR6
46 progressive relapsing multiple sclerosis 10.5 SERPINA3 H2AC18 CCR6
47 histoplasmosis 10.5 TNF CD4 CCR6
48 keratoconjunctivitis sicca 10.5 TNF CD4 CCR6
49 primary congenital glaucoma 10.5 PAX6 LOXL1 CRYAA
50 retinal vascular occlusion 10.5 LOXL1 IL6 CRYAA

Graphical network of the top 20 diseases related to Uveal Disease:



Diseases related to Uveal Disease

Symptoms & Phenotypes for Uveal Disease

UMLS symptoms related to Uveal Disease:


mydriasis; eye manifestations

MGI Mouse Phenotypes related to Uveal Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.65 BAP1 CD4 GNA11 GNAQ IL17A IL6
2 respiratory system MP:0005388 9.23 BAP1 GNA11 GNAQ IL17A IL6 LOXL1

Drugs & Therapeutics for Uveal Disease

Drugs for Uveal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved 1959-05-2, 59-05-2 126941
2
Prednisolone acetate Approved, Vet_approved 52-21-1
3
Methylprednisolone Approved, Vet_approved 83-43-2 6741
4
Prednisolone Approved, Vet_approved 50-24-8 5755
5
Methylprednisolone hemisuccinate Approved 2921-57-5
6
Levoleucovorin Approved, Investigational 68538-85-2 149436
7
Prednisolone phosphate Approved, Vet_approved 302-25-0
8
Etanercept Approved, Investigational 185243-69-0
9
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
10
Prednisolone hemisuccinate Experimental 2920-86-7
11 Folic Acid Antagonists
12 Vitamin B9
13 Gastrointestinal Agents
14 Analgesics, Non-Narcotic
15 Methylprednisolone Acetate
16 Antirheumatic Agents
17 Immunosuppressive Agents
18 Antineoplastic Agents, Hormonal
19 Analgesics
20 Hormone Antagonists
21 glucocorticoids
22 Vitamin B Complex
23 Hormones
24 Folate
25 Immunologic Factors
26 Dermatologic Agents
27 Antimetabolites
28 Anti-Inflammatory Agents
29 Anti-Inflammatory Agents, Non-Steroidal

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Etanercept: Single Blind Control Study in Ocular Manifestations of Behcet's Disease Unknown status NCT00931957 Etanercept, Methotrexate, Prednisolone

Search NIH Clinical Center for Uveal Disease

Cochrane evidence based reviews: uveal diseases

Genetic Tests for Uveal Disease

Anatomical Context for Uveal Disease

MalaCards organs/tissues related to Uveal Disease:

40
Eye

Publications for Uveal Disease

Articles related to Uveal Disease:

(show all 32)
# Title Authors PMID Year
1
Ophthalmologic findings associated with Rhodococcus equi bronchopneumonia in foals. 61
30706641 2019
2
Golden retriever cystic uveal disease: a longitudinal study of iridociliary cysts, pigmentary uveitis, and pigmentary/cystic glaucoma over a decade in western Canada. 61
26119416 2016
3
[Present status and development of prevention of blindness and ophthalmic epidemiologic studies in China]. 61
21176618 2010
4
Equine recurrent uveitis: the viewpoint from the USA. 61
20939168 2010
5
A prospective single arm phase II study of dacarbazine and treosulfan as first-line therapy in metastatic uveal melanoma. 61
16718271 2006
6
Primary intraocular lymphoma: a review of the clinical, histopathological and molecular biological features. 61
15565454 2004
7
[Clinical and epidemiological aspects in ocular tuberculosis]. 61
12035601 2001
8
Cystoid macular edema associated with the use of latanoprost. 61
9549261 1998
9
Cytokines: their role in uveal disease. 61
9349412 1997
10
[Ultrasound biomicroscopic imaging diagnosis of the anterior segment of the eye with high-frequency ultrasonic diagnostic equipment]. 61
8533655 1995
11
[A multicenter clinico-epidemiological study of HTLV-I associated uveitis]. 61
7976846 1994
12
Clinical features of HTLV-I associated uveitis determined in multicenter collaborative study. Study Group for HTLV-I Associated Ocular Diseases. 61
7967208 1994
13
HTLV-I associated uveitis and hyperthyroidism. 61
7933698 1994
14
Ocular disease in FeLV-positive cats: 11 cases (1981-1986). 61
1851738 1991
15
[Uveitis. A status assessment]. 61
2083890 1990
16
Bilateral anterior uveitis and interstitial nephritis. 61
3369519 1988
17
Oral acyclovir in the management of herpes simplex ocular infections. 61
3174010 1988
18
[Uveitis in acquired syphilis]. 61
4020042 1985
19
Ultrastructural localization of retinal S-antigen in the rat. 61
3979832 1985
20
Asymptomatic transient uveitis in children with inflammatory bowel disease. 61
420187 1979
21
A-mode echography in the diagnosis of uveal disease. 61
880517 1977
22
[Diagnosis of uveal diseases. (Unity of these diseases)]. 61
4272352 1973
23
[Dynamics of plasma kinin in eye diseases and effects of anti-kinin agents with special reference to retinal and uveal diseases]. 61
5458426 1970
24
Methotrexate treatment of uveal disease. 61
5904740 1966
25
[PRECIPITATION REACTIONS IN UVEAL DISEASES AND ITS COMPARISON WITH OTHER SEROLOGICAL TESTS AND REACTIONS]. 61
14305595 1965
26
[Clinical & experimental research work on the significance of hyperergic & toxic-bacterial factors in uveal diseases]. 61
13514963 1957
27
[Frequency of uveal diseases in patients with pulmonary tuberculosis]. 61
13514972 1957
28
[Post-traumatic uveal disease with cholesterol crystals: ocular xanthomatosis]. 61
13536692 1957
29
Retinal lesions associated with uveal disease. I. 61
13372709 1956
30
The influence of hypersensitivity on endogenous uveal disease. 61
20288588 1947
31
The influence of hypersensitivity on endogenous uveal disease. 61
20279194 1946
32
Concerning the Use of Diphtheria Antitoxin in Post-Operative Infections and Acute Uveal Disease. 61
16692610 1922

Variations for Uveal Disease

Expression for Uveal Disease

Search GEO for disease gene expression data for Uveal Disease.

Pathways for Uveal Disease

GO Terms for Uveal Disease

Cellular components related to Uveal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 photoreceptor outer segment GO:0001750 9.13 SAG GNAQ GNA11
2 external side of plasma membrane GO:0009897 9.02 TNF IL17A ICOSLG CD4 CCR6

Biological processes related to Uveal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.88 TNF IL6 IL17A CD4 CCR6
2 visual perception GO:0007601 9.71 RBP3 PAX6 CRYAA CHM
3 negative regulation of lipid storage GO:0010888 9.46 TNF IL6
4 phototransduction, visible light GO:0007603 9.43 GNAQ GNA11
5 humoral immune response GO:0006959 9.43 TNF IL6 CCR6
6 vascular endothelial growth factor production GO:0010573 9.37 TNF IL6
7 positive regulation of interleukin-1 beta production GO:0032731 9.33 TNF IL6 IL17A
8 entrainment of circadian clock GO:0009649 9.32 GNAQ GNA11
9 negative regulation of neurogenesis GO:0050768 9.13 TNF PAX6 IL6
10 positive regulation of cytokine production involved in inflammatory response GO:1900017 8.8 TNF IL6 IL17A

Molecular functions related to Uveal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor binding GO:0001664 9.13 SAG GNAQ GNA11
2 type 2A serotonin receptor binding GO:0031826 8.62 GNAQ GNA11

Sources for Uveal Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....