MCID: UVT001
MIFTS: 60

Uveitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Uveitis

MalaCards integrated aliases for Uveitis:

Name: Uveitis 12 76 29 55 44 15 73

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:13141
ICD10 33 H20.9
MeSH 44 D014605
NCIt 50 C26909
UMLS 73 C0042164

Summaries for Uveitis

MalaCards based summary : Uveitis is related to posterior uveitis and fuchs' heterochromic uveitis. An important gene associated with Uveitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Fluocinolone Acetonide and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and endothelial, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Uveitis is the inflammation of the uvea, the pigmented layer that lies between the inner retina and the... more...

Related Diseases for Uveitis

Diseases in the Uveitis family:

Posterior Uveitis Intermediate Uveitis
Infectious Anterior Uveitis Anterior Uveitis
Infectious Posterior Uveitis

Diseases related to Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 558)
# Related Disease Score Top Affiliating Genes
1 posterior uveitis 33.8 CAPN5 IFNG IL2RA RBP3 SAG TNF
2 fuchs' heterochromic uveitis 33.5 IL2RA TGFB2
3 intermediate uveitis 33.5 CXCR3 HLA-B IFNG IL10 IL2RA TNF
4 anterior uveitis 32.9 CCL2 CTLA4 HLA-B IL2RA
5 multifocal choroiditis 32.7 IL10 TNF
6 vitreoretinopathy, neovascular inflammatory 32.3 CAPN5 CCL2 TGFB2
7 vogt-koyanagi-harada disease 32.2 HLA-B IL10 IL17A IL2RA
8 panuveitis 32.0 HLA-B IL10 IL17A RBP3 SAG TNF
9 cytomegalovirus retinitis 31.4 HLA-B IFNG TNF
10 spondyloarthropathy 1 31.1 HLA-B IL17A NOD2 TNF
11 tropical spastic paraparesis 31.1 CXCR3 IFNG IL10 IL17A IL2RA
12 spondylitis 31.0 HLA-B IL17A NOD2 TNF
13 scleritis 30.9 CCL2 IL4 TNF
14 reactive arthritis 30.7 HLA-B IFNG IL10 TNF
15 acquired immunodeficiency syndrome 30.5 HLA-B IFNG IL10 TNF
16 herpes zoster 30.4 IFNA2 IFNG IL10
17 juvenile rheumatoid arthritis 30.4 IL1R1 IL2RA TNF
18 q fever 30.4 IFNG IL10 NOD2 TNF
19 vasculitis 30.3 CCL2 ICAM1 IFNA2 TNF
20 chlamydia 30.2 IFNG IL10 TNF
21 arthritis 30.2 CCL2 IFNG IL10 IL17A IL1A TNF
22 spotted fever 30.2 IFNG IL10 TNF
23 helicobacter pylori infection 30.2 IFNG IL10 TNF
24 meningitis 30.2 CCL2 IFNG IL10 TNF
25 rubella 30.1 HLA-B IL10 IL4 TNF
26 kawasaki disease 30.1 CCL2 IL10 TNF
27 granulomatous dermatitis 30.1 NOD2 TNF
28 extrapulmonary tuberculosis 30.1 CCL2 IFNG IL10
29 neuritis 30.1 CCL2 IFNG IL4 TNF
30 leptospirosis 30.1 CCL2 IL10 TNF
31 toxoplasmosis 30.1 IFNG IL10 IL4 TNF
32 stromal keratitis 30.0 CCL2 IL17A IL2RA TNF
33 conjunctivitis 30.0 ICAM1 IFNG IL4
34 oligoarticular juvenile idiopathic arthritis 30.0 CXCR3 IL2RA TNF
35 herpes simplex virus keratitis 29.9 CCL2 ICAM1
36 graft-versus-host disease 29.7 HLA-B IFNG IL10 IL1A TNF
37 chronic graft versus host disease 29.7 IFNG IL10 IL1A IL2RA
38 keratoconjunctivitis 29.7 ICAM1 IFNG IL4 TNF
39 allergic conjunctivitis 29.7 ICAM1 IFNG IL4
40 mastitis 29.6 ICAM1 IL17A NOD2
41 candidiasis 29.6 IFNG IL10 IL17A
42 peritonitis 29.6 CCL2 ICAM1 IL10 TNF
43 pertussis 29.6 IL10 IL1A TNF
44 psoriatic arthritis 29.5 HLA-B IL17A IL1A NOD2 TNF
45 keratoconjunctivitis sicca 29.5 IL10 IL1A IL4 TNF
46 aphthous stomatitis 29.5 HLA-B IL10 IL4 TNF
47 spondyloarthropathy 29.4 HLA-B IFNG IL10 IL17A IL4 TNF
48 vernal keratoconjunctivitis 29.3 CXCR3 ICAM1 IL4
49 brucellosis 29.3 IFNG IL10 IL2RA IL4 TNF
50 cytomegalovirus infection 29.3 ICAM1 IFNG IL10 IL2RA TNF

Graphical network of the top 20 diseases related to Uveitis:



Diseases related to Uveitis

Symptoms & Phenotypes for Uveitis

GenomeRNAi Phenotypes related to Uveitis according to GeneCards Suite gene sharing:

26 (show all 41)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.34 IL10
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.34 IFNA2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.34 IL10
4 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.34 IL1R1 IL2RA
5 Increased shRNA abundance (Z-score > 2) GR00366-A-116 10.34 IL1R1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.34 IL2RA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.34 IL1R1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.34 IL1R1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-125 10.34 IL10
10 Increased shRNA abundance (Z-score > 2) GR00366-A-127 10.34 IFNA2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-128 10.34 IL10
12 Increased shRNA abundance (Z-score > 2) GR00366-A-130 10.34 IL2RA
13 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10.34 IL10
14 Increased shRNA abundance (Z-score > 2) GR00366-A-138 10.34 IL2RA
15 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.34 IL10
16 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.34 IL10
17 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.34 IFNA2 IL1R1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.34 IL2RA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-174 10.34 IL2RA
20 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.34 IFNA2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-183 10.34 IL1R1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-185 10.34 IL2RA
23 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.34 IL2RA
24 Increased shRNA abundance (Z-score > 2) GR00366-A-198 10.34 IL1R1 IL10
25 Increased shRNA abundance (Z-score > 2) GR00366-A-2 10.34 IL2RA
26 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.34 IL2RA
27 Increased shRNA abundance (Z-score > 2) GR00366-A-210 10.34 IL10
28 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.34 IL10
29 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.34 IL10 IL2RA IFNA2 IL1R1
30 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.34 IFNA2
31 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.34 IL2RA
32 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.34 IL2RA
33 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.34 IL10 IL2RA
34 Increased shRNA abundance (Z-score > 2) GR00366-A-67 10.34 IL10 IL2RA
35 Increased shRNA abundance (Z-score > 2) GR00366-A-80 10.34 IL10
36 Increased shRNA abundance (Z-score > 2) GR00366-A-82 10.34 IL10
37 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.34 IL10
38 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.34 IL1R1 IL2RA
39 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.34 IL1R1
40 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 IL2RA ICAM1 IL17A IL1A IL10 TNF
41 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 IL2RA ICAM1 IL17A IL1A IL10 TNF

MGI Mouse Phenotypes related to Uveitis:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.31 CXCR3 IL10 ICAM1 IFNG CTLA4 IL1R1
2 immune system MP:0005387 10.31 ICAM1 IL17A CAPN5 IFNG CCL2 CTLA4
3 hematopoietic system MP:0005397 10.3 ICAM1 IFNG CTLA4 CXCR3 IL10 NOD2
4 growth/size/body region MP:0005378 10.26 IL10 ICAM1 CAPN5 IFNG IL1R1 NOD2
5 digestive/alimentary MP:0005381 10.21 IL10 ICAM1 IFNG CTLA4 NOD2 IL2RA
6 endocrine/exocrine gland MP:0005379 10.19 IL10 ICAM1 IFNG CTLA4 IL1R1 IL2RA
7 mortality/aging MP:0010768 10.17 CXCR3 IL10 ICAM1 CAPN5 IFNG CTLA4
8 craniofacial MP:0005382 10.07 IL10 IFNG IL4 IL1R1 IL17A TNF
9 integument MP:0010771 9.97 IL10 ICAM1 CTLA4 IFNG IL4 IL1R1
10 respiratory system MP:0005388 9.85 IFNG CTLA4 CXCR3 IL10 IL2RA IL17A
11 neoplasm MP:0002006 9.8 CXCR3 IL10 ICAM1 IFNG IL1R1 IL1A
12 skeleton MP:0005390 9.61 IL10 IFNG CTLA4 IL1R1 NOD2 IL17A
13 vision/eye MP:0005391 9.32 IL10 ICAM1 IFNG IL1R1 RBP3 IL2RA

Drugs & Therapeutics for Uveitis

Drugs for Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 266)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 67-73-2 6215
2
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 124-94-7 31307
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-02-2 5743
4
Tobramycin Approved, Investigational Phase 4 32986-56-4 5496 36294
5
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
6
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
7
Ranibizumab Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 347396-82-1 459903
8
Infliximab Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 170277-31-3
9
Azathioprine Approved Phase 4,Phase 3,Phase 2,Not Applicable 446-86-6 2265
10
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1959-05-2, 59-05-2 126941
11
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Not Applicable 128794-94-5 5281078
12
Mycophenolic acid Approved Phase 4,Phase 3,Not Applicable 24280-93-1 446541
13
Ephedrine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 299-42-3 9294
14
Pseudoephedrine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 90-82-4 7028
15
Diclofenac Approved, Vet_approved Phase 4,Phase 1,Not Applicable 15307-86-5 3033
16
Heparin Approved, Investigational Phase 4,Phase 2 9005-49-6 772 46507594
17
Adalimumab Approved Phase 4,Phase 2,Phase 3,Phase 1 331731-18-1 16219006
18
Ganciclovir Approved, Investigational Phase 4,Not Applicable 82410-32-0 3454
19
Chlorambucil Approved Phase 4 305-03-3 2708
20
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2 50-18-0, 6055-19-2 2907
21
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 53-03-2 5865
22
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
23
Bimatoprost Approved, Investigational Phase 4,Phase 3 155206-00-1 5311027
24
Latanoprost Approved, Investigational Phase 4,Phase 1,Not Applicable 130209-82-4 5282380 5311221
25
Timolol Approved Phase 4,Phase 3 26839-75-8 33624 5478
26
Travoprost Approved Phase 4 157283-68-6 5282226
27
Apraclonidine Approved Phase 4,Not Applicable 66711-21-5 2216
28
Dinoprost Tromethamine Approved, Vet_approved Phase 4 38562-01-5 5282415
29
Difluprednate Approved Phase 4,Phase 3,Phase 2 23674-86-4 443936
30
Fluprednisolone Approved Phase 4,Phase 3,Phase 2 53-34-9
31
Certolizumab pegol Approved Phase 4,Phase 3 428863-50-7
32
Nepafenac Approved, Investigational Phase 4 78281-72-8 151075
33
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-30-3 6037
34
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 143 6006
35
Tretinoin Approved, Investigational, Nutraceutical Phase 4 302-79-4 5538 444795
36
Lactitol Investigational Phase 4,Not Applicable 585-86-4 3871
37
Maleic acid Experimental Phase 4 110-16-7 444266
38
Dinoprost Investigational Phase 4 551-11-1 5283078
39 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
40 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
41 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
42 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
43 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
44 Immunosuppressive Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
45 triamcinolone acetonide Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Triamcinolone diacetate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Triamcinolone hexacetonide Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
49 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
50 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 436)
# Name Status NCT ID Phase Drugs
1 Flucinolone Acetonide Implant for Treating Refractory Ocular Behcet's Disease Unknown status NCT00720928 Phase 4 flucinolone acetonide
2 Posterior Subtenon Versus Intravitreal Injection of Triamcinolone Acetonide for Treatment of Uveitic Cystoid Macular Edema Unknown status NCT02598869 Phase 4 Triamcinolone Acetonide
3 Efficacy Comparison Study of Steroids to Control Post-operative Inflammation Unknown status NCT01801774 Phase 4 Subtenon 20-mg triamcinolone injection;Placebo
4 The Efficacy of Methylprednisolone in the Treatment of Patients With Ocular Involvement in Behcet's Disease Unknown status NCT01306955 Phase 4 methylorednisolone
5 Ozurdex Versus Ranibizumab Versus Combination for Central Retinal Vein Occlusion Unknown status NCT01827722 Phase 4 Ozurdex;Ranibizumab;Combination Ozurdex with Ranibizumab PRN
6 Combination OZURDEX® & LUCENTIS® vs. OZURDEX® Monotherapy in Incomplete-Responders With Diabetic Macular Edema Unknown status NCT02684084 Phase 4 Ozurdex;Lucentis
7 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
8 Multi Center Prospective Registry of Infliximab Use for Childhood Uveitis Completed NCT00589628 Phase 4 infliximab;infliximab
9 Multicenter Uveitis Steroid Treatment (MUST) Trial Completed NCT00132691 Phase 4 fluocinolone acetonide intraocular implant;oral corticosteroid with immunosuppressive agents as needed
10 Re-implantation of a Fluocinolone Acetonide Implant for Non-infectious Uveitis Affecting the Posterior Segment Completed NCT00543296 Phase 4 0.59 mg Fluocinolone Acetonide implant
11 TAHOE: Intravitreal Dexamethasone Implant (Ozurdex) for Uveitic Macular Edema Completed NCT01870440 Phase 4 Ozurdex Intravitreal Injection (0.7 mg)
12 The Incidence of Extra-Articular Manifestations in Participants With Ankylosing Spondylitis Treated With Golimumab (MK-8259-012) Completed NCT01668004 Phase 4
13 A Study to Compare Ocular Safety and Tolerability of Eye Drops Containing Prednisolone Acetate in Patients With Intraocular Inflammation After Cataract Surgery Completed NCT00170729 Phase 4 Prednisolone acetate
14 Blood-aqueous Barrier Changes After the Use of Timolol and Prostaglandin Analogues Fixed Combination in Pseudophakic Patients With POAG Completed NCT01978015 Phase 4 travoprost and timolol maleate fixed combination;latanoprost and maleate timolol fixed combination;bimatoprost and timolol maleate fixed combination;dextran and hypromellose
15 Micropulse Laser Trabeculoplasty (MLT) Versus Selective Laser Trabeculoplasty (SLT) for Treatment of Open Angle Glaucoma Completed NCT01956942 Phase 4
16 Steroids After Laser Trabeculoplasty for Glaucoma Completed NCT00981435 Phase 4 Prednisolone 1%;Ketorolac;Artificial Tears
17 The Effects of BAK on the Blood Aqueous Barrier of Pseudophakic Patients Completed NCT01280110 Phase 4 Hydroxypropylmethylcellulose;Carboxymethylcellulose
18 Evaluation of Dosing Interval of Higher Doses of Ranibizumab Completed NCT00533520 Phase 4 ranibizumab
19 Aqueous Flare of a Hydrophobic Acrylic Single-piece Open-loop IOL With Modified Material Surface Properties Completed NCT01767012 Phase 4
20 Infliximab for the Prevention of Recurrent Crohn's Disease After Surgery Completed NCT00688636 Phase 4 infliximab;placebo
21 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) Completed NCT02059655 Phase 4 Bimatoprost;Eye drop solution
22 A Study Treating Participants With Early Axial Spondyloarthritis (axSpA) Taking an Intense Treatment Approach Versus Routine Treatment Completed NCT02897115 Phase 4
23 Intravitreal Aflibercept Injection for the Treatment of Submacular Vascularized Pigment Epithelial Detachment Completed NCT01722656 Phase 4 Aflibercept
24 Saline vs. Lactated Ringers for Emergency Department IV Fluid Resuscitation Completed NCT03133767 Phase 4 Lactated Ringer Solution;Normal Saline 0.9% Infusion Solution Bag
25 Open Label Study of Acthar SQ Gel Injection in Patients With Active Anterior Uveitis Recruiting NCT02769702 Phase 4 Acthar
26 Study of the Effectiveness of Ozurdex for the Control of Uveitis Recruiting NCT02049476 Phase 4 Dexamethasone pellet
27 Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis Recruiting NCT02943057 Phase 4 2% guttae ganciclovir
28 Efficacy and Safety of H.P. ACTHAR GEL in Adults With Retinal Vasculitis Recruiting NCT03066869 Phase 4 H.P. ACTHAR GEL
29 A Study to Assess the Effects of Certolizumab Pegol on the Reduction of Anterior Uveitis (AU) Flares in Axial Spondyloarthritis Subjects With a Documented History of AU Active, not recruiting NCT03020992 Phase 4 Certolizumab Pegol
30 Macular Edema Nepafenac vs. Difluprednate Uveitis Trial Not yet recruiting NCT01939691 Phase 4 Difluprednate;Nepafenac;Prednisolone acetate
31 Effect of Intracameral Dexamethasone After Phacoemulsification in Diabetics on Corneal Endothelial Cell Density Not yet recruiting NCT03361709 Phase 4 Dexamethasone;Saline Solutions, Intraocular
32 Effects of Ranibizumab to Delay or Regression Non-proliferative Diabetic Retinopathy(NPDR) With DME Assessed by Microaneurysm Changes: A Pilot Study Not yet recruiting NCT02834663 Phase 4 Lucentis
33 Use of Thalidomide in Chronic Uveitis Terminated NCT00314665 Phase 4 Thalidomide
34 Efficacy Study of Methotrexate to Treat Sarcoid-associated Uveitis Terminated NCT00918554 Phase 4 Methotrexate;Placebo
35 Methotrexate in the Treatment of Axial Spondyloarthritis Withdrawn NCT00298012 Phase 4 Methotrexate
36 Adalimumab in Uveitis Refractory to Conventional Therapy (ADUR Trial) Unknown status NCT00348153 Phase 2, Phase 3 Adalimumab
37 The Safety and Efficacy of a Tumor Necrosis Factor Receptor Fusion Protein on Uveitis Associated With Juvenile Rheumatoid Arthritis Unknown status NCT00012506 Phase 3 TNFR:Fc
38 Collaborative Ocular Melanoma Study (COMS) Unknown status NCT00000124 Phase 3
39 Topical Dexamethasone - Cyclodextrin Microparticle Eye Drops for Diabetic Macular Edema Unknown status NCT01523314 Phase 2, Phase 3 dexamethasone - Cyclodextrin eye drops
40 Evaluation of Seelens AF, an Aspheric Intra-Ocular Lens Unknown status NCT00825747 Phase 3
41 To Compare Intravitreal Clindamycin & Dexamethasone With Classic Treatment of Toxoplasmic Retinochoroiditis Unknown status NCT00372294 Phase 3 pyrimethamine-sulfadiazine + prednisolone;Clindamycin+Dexamethasone
42 A Study of Strontium90 Beta Radiation With Lucentis to Treat Age-Related Macular Degeneration Unknown status NCT00454389 Phase 3 ranibizumab
43 A Study of the Long-term Safety and Efficacy of Adalimumab in Subjects With Intermediate-, Posterior-, or Pan-uveitis Completed NCT01148225 Phase 3 adalimumab
44 Efficacy and Safety of Adalimumab in Subjects With Inactive Uveitis Completed NCT01124838 Phase 3 Adalimumab;Prednisone;Placebo
45 Effect of Adalimumab for the Treatment of Uveitis in Juvenile Idiopathic Arthritis Completed NCT01385826 Phase 2, Phase 3 Anti-tumor necrosis factor alpha monoclonal antibody;placebo
46 First-line Antimetabolites as Steroid-sparing Treatment Uveitis Pilot Trial Completed NCT01232920 Phase 3 Methotrexate;Mycophenolate mofetil
47 Safety and Efficacy Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution to Treat Non-Infectious Anterior Segment Uveitis Completed NCT01505088 Phase 3 40 mg/mL Dexamethasone phosphate ophthalmic solution;Prednisolone Acetate (1%) Eyedrops;100 mM sodium citrate buffer solution;Placebo Eyedrops
48 Efficacy and Safety of Adalimumab in Patients With Active Uveitis Completed NCT01138657 Phase 3 Prednisone;Placebo
49 Randomized, Controlled Trial to Test the Efficacy of Interferon Beta in the Treatment of Intermediate Uveitis Completed NCT00344253 Phase 3 Interferon beta;Methotrexate
50 Efficacy and Safety of Voclosporin to Treat Active Noninfectious Uveitis Completed NCT01243983 Phase 3 LX211

Search NIH Clinical Center for Uveitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: uveitis

Genetic Tests for Uveitis

Genetic tests related to Uveitis:

# Genetic test Affiliating Genes
1 Uveitis 29

Anatomical Context for Uveitis

MalaCards organs/tissues related to Uveitis:

41
Eye, T Cells, Endothelial, Retina, Testes, Lung, Skin

Publications for Uveitis

Articles related to Uveitis:

(show top 50) (show all 2430)
# Title Authors Year
1
Presumed tuberculous uveitis in a university-based tertiary referral center in Saudi Arabia. ( 29318438 )
2018
2
Inflammatory bowel disease and acute anterior uveitis, but not psoriasis are associated with disease duration in Axial SpA: results from the (Be)Giant and ASPECT cohort. ( 29740978 )
2018
3
DETECTION OF TYPE 1 CHOROIDAL NEOVASCULAR MEMBRANES USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN TUBERCULAR POSTERIOR UVEITIS. ( 29689028 )
2018
4
Early treatment of tuberculous uveitis improves visual outcome: a 10-year cohort study. ( 29869018 )
2018
5
Diagnosis of Cytomegalovirus Anterior Uveitis in Two European Referral Centers. ( 29377783 )
2018
6
The pathogenic role of dendritic cells in non-infectious anterior uveitis. ( 29763582 )
2018
7
Management of Uveitis in Spondyloarthropathy: Current Trends. ( 29272246 )
2018
8
Superficial and deep retinal foveal avascular zone OCTA findings of non-infectious anterior and posterior uveitis. ( 29980918 )
2018
9
Increased Circulating Proinflammatory T Lymphocytes in Children with Different Forms of Anterior Uveitis: Results from a Pilot Study. ( 29771573 )
2018
10
Optimising drug therapy for non-infectious uveitis. ( 29961190 )
2018
11
Need for Quantitative Measurement Methods for Posterior Uveitis: Comparison of Dual FA/ICGA Angiography, EDI-OCT Choroidal Thickness and SUN Vitreous Haze Evaluation in Stromal Choroiditis. ( 29669371 )
2018
12
Bevacizumab Diminishes Inflammation in an Acute Endotoxin-Induced Uveitis Model. ( 29971005 )
2018
13
Recurrent anterior uveitis and subsequent incidence of ankylosing spondylitis: a nationwide cohort study from 2002 to 2013. ( 29415753 )
2018
14
Safety and Efficacy of Adalimumab in Patients with Noninfectious Uveitis in an Ongoing Open-Label Study: VISUAL III. ( 29429764 )
2018
15
Uveitis and internuclear ophthalmoplegia as ocular manifestations of sarcoidosis. ( 29942190 )
2018
16
A study of the key genes and inflammatory signaling pathways involved in HLA-B27-associated acute anterior uveitis families. ( 29620146 )
2018
17
Clinical Characteristics of Herpes Simplex Virus Associated Anterior Uveitis. ( 29345511 )
2018
18
Familial Blau syndrome without uveitis caused by a novel mutation in the nucleotide-binding oligomerization domain-containing protein 2 gene with good response to infliximab. ( 29570830 )
2018
19
Mosquito-Borne Uveitis. ( 29969369 )
2018
20
Elevated interleukin 37 expression associated with disease activity in HLA-B27 associated anterior uveitis and idiopathic anterior uveitis. ( 29424310 )
2018
21
Cyclophosphamide or Rituximab Treatment of Scleritis and Uveitis for Patients with Granulomatosis with Polyangiitis. ( 29635229 )
2018
22
Complications in Intermediate Uveitis: Prevalence, Time of Onset, and Effects on Vision in Short-Term and Long-Term Follow-Up. ( 29370567 )
2018
23
Childhood Arthritis and Rheumatology Research Alliance consensus treatment plans for juvenile idiopathic arthritis-associated and idiopathic chronic anterior uveitis. ( 29806733 )
2018
24
Efficacy and Safety of Mycophenolate Mofetil in the Treatment of Recalcitrant Intermediate Uveitis. ( 29652198 )
2018
25
Fever of unknown origin, bilateral sensorineural hearing loss with canal paresis and uveitis with iridocyclitis and episcleritis: a case of Cogan's syndrome. ( 29703835 )
2018
26
Association of genetic variants in<i>RAB23</i>and<i>ANXA11</i>with uveitis in sarcoidosis. ( 29416296 )
2018
27
Association of IL33 and IL1RAP polymorphisms with acute anterior uveitis. ( 29424312 )
2018
28
Clinical Features of CMV-Associated Anterior Uveitis. ( 29172842 )
2018
29
Macular Edema in Childhood Uveitis. ( 29452454 )
2018
30
Catching the therapeutic window of opportunity in early initial-onset Vogt-Koyanagi-Harada uveitis can cure the disease. ( 29948499 )
2018
31
Editorial: Uveitis: Pathology, Molecular Mechanisms and Therapy. ( 29424309 )
2018
32
Immunopathology of Virus-Induced Anterior Uveitis. ( 29543540 )
2018
33
Different composition of intraocular immune mediators in Posner-Schlossman-Syndrome and Fuchs' Uveitis. ( 29944680 )
2018
34
Tubulointerstitial nephritis and uveitis syndrome in children: report of three cases. ( 29944160 )
2018
35
Scleroderma &amp;quot;en coup de sabre&amp;quot; With Epilepsy and Uveitis Successfully Treated With Tocilizumab. ( 29929808 )
2018
36
An Intraocular Inflammatory Profile of Rubella Associated Uveitis. ( 29370571 )
2018
37
A case of conjunctival ulcer and uveitis caused byA AcrophialophoraA sp. in an immunocompromised patient; a case report and literature review. ( 29962481 )
2018
38
Hypertensive acute granulomatous anterior uveitis as a side effect of topical brimonidine. ( 29910082 )
2018
39
Necrotising scleritis, keratitis and uveitis in primary antiphospholipid syndrome. ( 29764818 )
2018
40
Tonic Pupil in Cytomegalovirus Anterior Uveitis in an Immunocompetent Adult Male - A Case Report. ( 29028408 )
2018
41
Multiplex Cytokine Analysis of Aqueous Humor in Juvenile Idiopathic Arthritis-Associated Anterior Uveitis With or Without Secondary Glaucoma. ( 29675026 )
2018
42
Efficacy of Natalizumab in Intermediate Uveitis Related to Multiple Sclerosis: A Case Report. ( 29452449 )
2018
43
Cataract surgery combined with micro-incision vitrectomy in patients with behcet's disease uveitis. ( 29954349 )
2018
44
Contribution of diagnostic tests for the etiological assessment of uveitis, data from the ULISSE study (Uveitis: Clinical and medicoeconomic evaluation of a standardized strategy of the etiological diagnosis). ( 29427823 )
2018
45
The Syndrome of Tubulointerstitial Nephritis With Uveitis (TINU). ( 29429748 )
2018
46
A Cross-Sectional Observational Study of Nailfold Capillary Morphology in Uveitis. ( 29966450 )
2018
47
Novel microsurgical management of uveitis-glaucoma-hyphema syndrome. ( 29943072 )
2018
48
Prevalence of axial spondyloarthritis in patients with acute anterior uveitis: a cross-sectional study utilising MRI. ( 29531779 )
2018
49
Granulomatous Tattoo reaction with Associated Uveitis successfully treated with methotrexate. ( 29419907 )
2018
50
Relapse of Juvenile Idiopathic Arthritis-Associated Uveitis after Discontinuation of Immunomodulatory Therapy. ( 29451845 )
2018

Variations for Uveitis

Expression for Uveitis

Search GEO for disease gene expression data for Uveitis.

Pathways for Uveitis

Pathways related to Uveitis according to GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.11 CCL2 CTLA4 HLA-B ICAM1 IFNA2 IFNG
2
Show member pathways
13.92 CAPN5 CCL2 CXCR3 IL10 IL17A IL1A
3
Show member pathways
13.76 CCL2 CXCR3 IFNA2 IFNG IL10 IL17A
4
Show member pathways
13.56 CCL2 IFNA2 IFNG IL10 IL17A IL1A
5
Show member pathways
13.5 CCL2 CXCR3 IL10 IL17A IL1A IL1R1
6
Show member pathways
13.37 CCL2 CXCR3 IL10 IL17A IL1A IL1R1
7
Show member pathways
13.36 CCL2 HLA-B ICAM1 IFNA2 IFNG IL10
8
Show member pathways
13.09 CCL2 IFNA2 IFNG IL10 NOD2 TGFB2
9
Show member pathways
12.88 CCL2 HLA-B ICAM1 IFNA2 IFNG IL1A
10 12.86 IFNA2 IFNG IL2RA IL4 TGFB2
11
Show member pathways
12.86 IFNG IL1A IL1R1 IL2RA IL4 TNF
12
Show member pathways
12.85 CTLA4 HLA-B ICAM1 IFNA2 IFNG IL10
13
Show member pathways
12.65 CCL2 IFNG IL10 IL17A TNF
14
Show member pathways
12.65 HLA-B IFNA2 IFNG IL10 IL17A IL1A
15
Show member pathways
12.63 HLA-B ICAM1 IFNA2 TGFB2 TNF
16
Show member pathways
12.63 HLA-B ICAM1 IFNA2 IFNG IL4 TNF
17 12.62 CCL2 CTLA4 IFNG IL10 IL17A IL2RA
18 12.54 HLA-B ICAM1 IL1R1 IL2RA TGFB2 TNF
19
Show member pathways
12.52 CTLA4 IFNG IL10 IL17A IL1A IL4
20
Show member pathways
12.46 CAPN5 IL1A IL1R1 IL2RA
21
Show member pathways
12.42 CCL2 ICAM1 IFNG IL4 TNF
22
Show member pathways
12.42 CCL2 IFNG IL17A IL4 TNF
23
Show member pathways
12.37 IFNG IL10 IL17A IL1R1 TGFB2 TNF
24
Show member pathways
12.36 IFNG IL10 IL1A IL4 TGFB2 TNF
25
Show member pathways
12.34 CCL2 IL1A IL1R1 NOD2
26 12.34 HLA-B ICAM1 IFNG IL10
27 12.34 IFNA2 IFNG IL10 IL1A NOD2 TGFB2
28
Show member pathways
12.32 IFNG IL1A IL1R1 TNF
29
Show member pathways
12.26 IFNA2 IFNG IL1A TNF
30
Show member pathways
12.24 IFNG IL1R1 IL4 TNF
31 12.2 CCL2 ICAM1 IFNG IL1A IL1R1 TNF
32 12.17 IFNG IL1A IL1R1 TGFB2 TNF
33 12.13 CCL2 ICAM1 IFNG IL1A IL1R1 IL4
34 12.1 IFNA2 IFNG IL10 IL2RA IL4 TNF
35 12.1 CCL2 ICAM1 IL10 IL17A IL1A IL4
36
Show member pathways
12.08 IFNG IL10 IL17A IL1A IL1R1 IL2RA
37
Show member pathways
12.05 IFNG IL1R1 IL2RA IL4
38 12.04 CCL2 ICAM1 IL1A TGFB2 TNF
39 12.03 CCL2 ICAM1 NOD2 TNF
40
Show member pathways
12.03 CCL2 ICAM1 IFNG IL10 IL17A IL1A
41 12.02 IL1A IL1R1 IL2RA IL4 TNF
42 12 IFNG IL10 IL1R1 TGFB2 TNF
43 11.96 IFNA2 IFNG IL10 IL2RA
44 11.9 ICAM1 IL1R1 TNF
45
Show member pathways
11.87 CTLA4 IFNG IL2RA IL4 TNF
46 11.85 IFNA2 IFNG IL10 TNF
47 11.84 IFNG TGFB2 TNF
48 11.83 ICAM1 IFNG IL4
49 11.79 IL10 IL1A TNF
50
Show member pathways
11.78 ICAM1 IFNG IL1A TNF

GO Terms for Uveitis

Cellular components related to Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.9 CCL2 ICAM1 IFNA2 IFNG IL10 IL17A
2 cell surface GO:0009986 9.56 CAPN5 CXCR3 HLA-B ICAM1 IL1R1 IL2RA
3 external side of plasma membrane GO:0009897 9.17 CTLA4 CXCR3 ICAM1 IL17A IL1R1 IL2RA
4 extracellular region GO:0005576 10 CCL2 IFNA2 IFNG IL10 IL17A IL1A

Biological processes related to Uveitis according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.97 IFNA2 IFNG TGFB2 TNF
2 regulation of signaling receptor activity GO:0010469 9.91 CCL2 IFNA2 IFNG IL10 IL17A IL1A
3 cellular response to lipopolysaccharide GO:0071222 9.88 CCL2 ICAM1 IL10 TNF
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.88 CCL2 ICAM1 IL1A NOD2 TNF
5 cell surface receptor signaling pathway GO:0007166 9.87 CCL2 CXCR3 IFNA2 IFNG IL1R1 IL2RA
6 regulation of inflammatory response GO:0050727 9.85 IL1R1 NOD2 TNF
7 cellular response to interleukin-1 GO:0071347 9.85 CCL2 ICAM1 IL17A
8 cellular response to organic cyclic compound GO:0071407 9.85 CCL2 NOD2 TNF
9 B cell differentiation GO:0030183 9.84 IFNA2 IL10 IL4
10 positive regulation of JNK cascade GO:0046330 9.83 IL1A NOD2 TNF
11 interferon-gamma-mediated signaling pathway GO:0060333 9.83 HLA-B ICAM1 IFNG
12 inflammatory response GO:0006954 9.81 CCL2 CXCR3 IFNA2 IL10 IL17A IL1A
13 positive regulation of interleukin-6 production GO:0032755 9.8 IL1A NOD2 TNF
14 extrinsic apoptotic signaling pathway GO:0097191 9.78 IFNG TGFB2 TNF
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 ICAM1 IFNG TNF
16 negative regulation of T cell proliferation GO:0042130 9.76 CTLA4 IL10 IL2RA
17 negative regulation of endothelial cell apoptotic process GO:2000352 9.74 ICAM1 IL10 IL4
18 humoral immune response GO:0006959 9.71 CCL2 IFNA2 IFNG TNF
19 immune response GO:0006955 9.7 CCL2 CTLA4 HLA-B IFNG IL10 IL17A
20 positive regulation of cytokine secretion GO:0050715 9.69 IL10 IL1A TNF
21 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.68 IL10 TNF
22 negative regulation of immune response GO:0050777 9.67 CTLA4 IL2RA NOD2 TGFB2
23 endothelial cell apoptotic process GO:0072577 9.65 IL10 TNF
24 positive regulation of MHC class II biosynthetic process GO:0045348 9.65 IL10 IL4
25 negative regulation of cytokine secretion involved in immune response GO:0002740 9.64 IL10 TNF
26 type 2 immune response GO:0042092 9.63 IL10 IL4
27 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.63 ICAM1 TNF
28 positive regulation of osteoclast differentiation GO:0045672 9.63 IFNG IL17A TNF
29 positive regulation of neutrophil extravasation GO:2000391 9.62 IL1A IL1R1
30 positive regulation of interleukin-23 production GO:0032747 9.61 IFNG IL17A
31 regulation of regulatory T cell differentiation GO:0045589 9.61 CTLA4 IFNG IL2RA
32 regulation of isotype switching GO:0045191 9.59 IL10 IL4
33 receptor biosynthetic process GO:0032800 9.56 IL10 TNF
34 regulation of complement-dependent cytotoxicity GO:1903659 9.55 IL10 TGFB2
35 negative regulation of alkaline phosphatase activity GO:0010693 9.54 TGFB2 TNF
36 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.52 IFNG TNF
37 positive regulation of vitamin D biosynthetic process GO:0060557 9.49 IFNG TNF
38 cytokine-mediated signaling pathway GO:0019221 9.32 CCL2 ICAM1 IFNA2 IL10 IL17A IL1A
39 apoptotic process GO:0006915 10.12 CXCR3 IFNA2 IFNG IL17A IL1A IL2RA

Molecular functions related to Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 CCL2 IFNA2 IFNG IL10 IL17A IL1A

Sources for Uveitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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