MCID: UVT001
MIFTS: 61

Uveitis

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Uveitis

MalaCards integrated aliases for Uveitis:

Name: Uveitis 12 76 29 55 44 15 40 73

Classifications:



External Ids:

Disease Ontology 12 DOID:13141
ICD10 33 H20.9
MeSH 44 D014605
NCIt 50 C26909
SNOMED-CT 68 75614007
UMLS 73 C0042164

Summaries for Uveitis

MalaCards based summary : Uveitis is related to posterior uveitis and fuchs' heterochromic uveitis. An important gene associated with Uveitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Fluocinolone Acetonide and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and endothelial, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Uveitis is the inflammation of the uvea, the pigmented layer that lies between the inner retina and the... more...

Related Diseases for Uveitis

Diseases in the Uveitis family:

Autoimmune Uveitis Posterior Uveitis
Intermediate Uveitis Infectious Anterior Uveitis
Anterior Uveitis Infectious Posterior Uveitis

Diseases related to Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 622)
# Related Disease Score Top Affiliating Genes
1 posterior uveitis 33.9 CAPN5 IFNG IL2RA RBP3 SAG TNF
2 fuchs' heterochromic uveitis 33.9 IL2RA TGFB2
3 intermediate uveitis 33.7 CXCR3 HLA-B IFNG IL10 IL2RA TNF
4 anterior uveitis 33.7 HLA-B IL2RA TNF
5 vitreoretinopathy, neovascular inflammatory 32.4 CAPN5 CCL2 TGFB2
6 multifocal choroiditis 32.4 IL10 TNF
7 autoimmune uveitis 32.3 CAPN5 CCL2 ICAM1 IFNG IL10 IL17A
8 panuveitis 32.3 HLA-B IL10 IL17A RBP3 SAG TNF
9 tropical spastic paraparesis 31.3 CXCR3 HLA-B IFNG IL10 IL17A IL2RA
10 juvenile rheumatoid arthritis 31.0 IL1R1 IL2RA TNF
11 spondyloarthropathy 1 30.9 HLA-B IL17A NOD2 TNF
12 spondylitis 30.9 HLA-B IL17A NOD2 TNF
13 cytomegalovirus retinitis 30.8 HLA-B IFNG TNF
14 macular retinal edema 30.8 CAPN5 CCL2 ICAM1
15 arthritis 30.8 CCL2 IFNG IL10 IL17A IL1A NOD2
16 behcet syndrome 30.7 CTLA4 HLA-B IFNA2 IFNG IL10 IL17A
17 scleritis 30.5 CCL2 IFNG IL4 TNF
18 vasculitis 30.4 CCL2 HLA-B ICAM1 IFNA2 TNF
19 vogt-koyanagi-harada disease 30.4 HLA-B IL10 IL17A IL2RA
20 kawasaki disease 30.2 CCL2 IL10 TNF
21 conjunctivitis 30.2 ICAM1 IFNG IL4
22 neuritis 30.2 CCL2 IFNG IL4 TNF
23 herpes zoster 30.1 HLA-B IFNA2 IFNG IL10
24 oligoarticular juvenile idiopathic arthritis 30.1 CXCR3 IL2RA TNF
25 rubella 30.1 HLA-B IL10 IL4 TNF
26 human immunodeficiency virus infectious disease 30.1 IFNG IL10 TNF
27 toxoplasmosis 30.0 IFNG IL10 IL4 TNF
28 psoriatic arthritis 30.0 HLA-B IL17A IL1A NOD2 TNF
29 reactive arthritis 30.0 HLA-B IFNG IL10 IL17A TNF
30 meningitis 30.0 CCL2 IFNG IL10 TNF
31 spotted fever 29.9 IFNG IL10 TNF
32 temporal arteritis 29.9 CCL2 IFNG TNF
33 mumps 29.9 IFNG IL2RA TNF
34 extrapulmonary tuberculosis 29.9 CCL2 IFNG IL10
35 sarcoidosis 1 29.9 CCL2 CXCR3 ICAM1 IFNG IL2RA NOD2
36 spondyloarthropathy 29.9 HLA-B IFNG IL10 IL17A IL4 TNF
37 stromal keratitis 29.9 CCL2 IL17A IL2RA TNF
38 drug reaction with eosinophilia and systemic symptoms 29.9 HLA-B TNF
39 viral infectious disease 29.9 IFNA2 IFNG IL10 IL4 TNF
40 ulcerative colitis 29.9 IFNG IL10 IL17A NOD2 TNF
41 acquired immunodeficiency syndrome 29.8 HLA-B IFNA2 IFNG IL10 IL2RA TNF
42 keratoconjunctivitis 29.8 ICAM1 IFNG IL4 TNF
43 herpes simplex virus keratitis 29.8 CCL2 ICAM1
44 chlamydia 29.7 IFNG IL10 IL1A IL4 TNF
45 leptospirosis 29.7 CCL2 IFNG IL10 TNF
46 allergic conjunctivitis 29.7 ICAM1 IFNG IL4
47 cytomegalovirus infection 29.7 CCL2 HLA-B TNF
48 pertussis 29.7 IL10 IL1A TNF
49 q fever 29.6 IFNG IL10 IL4 NOD2 TNF
50 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 29.6 CTLA4 IFNG IL10 IL17A

Graphical network of the top 20 diseases related to Uveitis:



Diseases related to Uveitis

Symptoms & Phenotypes for Uveitis

GenomeRNAi Phenotypes related to Uveitis according to GeneCards Suite gene sharing:

26 (show all 40)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.33 IL10
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.33 IFNA2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.33 IL10
4 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.33 IL1R1 IL2RA
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.33 IL2RA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.33 IL1R1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.33 IL1R1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-125 10.33 IL10
9 Increased shRNA abundance (Z-score > 2) GR00366-A-127 10.33 IFNA2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-128 10.33 IL10
11 Increased shRNA abundance (Z-score > 2) GR00366-A-130 10.33 IL2RA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10.33 IL10
13 Increased shRNA abundance (Z-score > 2) GR00366-A-138 10.33 IL2RA
14 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.33 IL10
15 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.33 IL10
16 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.33 IFNA2 IL1R1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.33 IL2RA
18 Increased shRNA abundance (Z-score > 2) GR00366-A-174 10.33 IL2RA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.33 IFNA2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-183 10.33 IL1R1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-185 10.33 IL2RA
22 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.33 IL2RA
23 Increased shRNA abundance (Z-score > 2) GR00366-A-198 10.33 IL10 IL1R1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-2 10.33 IL2RA
25 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.33 IL2RA
26 Increased shRNA abundance (Z-score > 2) GR00366-A-210 10.33 IL10
27 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.33 IL10
28 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.33 IFNA2 IL10 IL1R1 IL2RA
29 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.33 IFNA2
30 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.33 IL2RA
31 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.33 IL2RA
32 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.33 IL10 IL2RA
33 Increased shRNA abundance (Z-score > 2) GR00366-A-67 10.33 IL10 IL2RA
34 Increased shRNA abundance (Z-score > 2) GR00366-A-80 10.33 IL10
35 Increased shRNA abundance (Z-score > 2) GR00366-A-82 10.33 IL10
36 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.33 IL10
37 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.33 IL1R1 IL2RA
38 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.33 IL1R1
39 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 ICAM1 IL10 IL17A IL1A IL2RA NOD2
40 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 ICAM1 IL10 IL17A IL1A IL2RA NOD2

MGI Mouse Phenotypes related to Uveitis:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.31 CTLA4 CXCR3 ICAM1 IFNG IL10 IL17A
2 immune system MP:0005387 10.31 CAPN5 CCL2 CTLA4 CXCR3 ICAM1 IFNG
3 hematopoietic system MP:0005397 10.3 CTLA4 CXCR3 ICAM1 IFNG IL10 IL17A
4 growth/size/body region MP:0005378 10.26 CAPN5 ICAM1 IFNG IL10 IL17A IL1R1
5 digestive/alimentary MP:0005381 10.21 CTLA4 ICAM1 IFNG IL10 IL17A IL2RA
6 endocrine/exocrine gland MP:0005379 10.19 CTLA4 ICAM1 IFNG IL10 IL17A IL1R1
7 mortality/aging MP:0010768 10.17 CAPN5 CTLA4 CXCR3 ICAM1 IFNG IL10
8 craniofacial MP:0005382 10.07 IFNG IL10 IL17A IL1R1 IL4 TGFB2
9 integument MP:0010771 9.97 CTLA4 ICAM1 IFNG IL10 IL1A IL1R1
10 respiratory system MP:0005388 9.85 CTLA4 CXCR3 IFNG IL10 IL17A IL1R1
11 neoplasm MP:0002006 9.8 CXCR3 ICAM1 IFNG IL10 IL1A IL1R1
12 skeleton MP:0005390 9.61 CTLA4 IFNG IL10 IL17A IL1R1 IL4
13 vision/eye MP:0005391 9.32 ICAM1 IFNG IL10 IL1R1 IL2RA IL4

Drugs & Therapeutics for Uveitis

Drugs for Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 286)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 67-73-2 6215
2
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 124-94-7 31307
3
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 1177-87-3
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-02-2 5743
5
Tobramycin Approved, Investigational Phase 4 32986-56-4 36294 5496
6
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
7
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
8
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 302-25-0
9
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2921-57-5
10
Ranibizumab Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 347396-82-1 459903
11
Infliximab Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 170277-31-3
12
Mycophenolic acid Approved Phase 4,Phase 3,Not Applicable 24280-93-1 446541
13
Azathioprine Approved Phase 4,Phase 3,Phase 2,Not Applicable 446-86-6 2265
14
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-05-2, 1959-05-2 126941
15
Diclofenac Approved, Vet_approved Phase 4,Phase 1,Not Applicable 15307-86-5 3033
16
Heparin Approved, Investigational Phase 4,Phase 2 9005-49-6 772 46507594
17
Adalimumab Approved Phase 4,Phase 2,Phase 3,Phase 1 331731-18-1 16219006
18
Ganciclovir Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 82410-32-0 3454
19
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 6006 143
20
Chlorambucil Approved Phase 4 305-03-3 2708
21
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2 6055-19-2, 50-18-0 2907
22
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 53-03-2 5865
23
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
24
Travoprost Approved Phase 4 157283-68-6 5282226
25
Bimatoprost Approved, Investigational Phase 4,Phase 3 155206-00-1 5311027
26
Timolol Approved Phase 4,Phase 3 26839-75-8 33624 5478
27
Latanoprost Approved, Investigational Phase 4,Phase 1,Not Applicable 130209-82-4 5311221 5282380
28
Apraclonidine Approved Phase 4,Not Applicable 66711-21-5 2216
29
Ketorolac Approved Phase 4,Phase 1 66635-83-4, 74103-06-3 3826
30
Dinoprost Tromethamine Approved, Vet_approved Phase 4 38562-01-5 5282415
31
Dinoprost Approved, Investigational Phase 4 551-11-1 5283078
32
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
33
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
34 Estradiol valerate Approved, Investigational, Vet_approved Phase 4 979-32-8
35
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
36
Polyestradiol phosphate Approved Phase 4 28014-46-2
37
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
38
Difluprednate Approved Phase 4,Phase 3,Phase 2 23674-86-4 443936
39
Fluprednisolone Approved Phase 4,Phase 3,Phase 2 53-34-9
40
Nepafenac Approved, Investigational Phase 4 78281-72-8 151075
41
Certolizumab pegol Approved Phase 4,Phase 3 428863-50-7
42
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-30-3 6037
43
Tretinoin Approved, Investigational, Nutraceutical Phase 4 302-79-4 5538 444795
44
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2920-86-7
45
Maleic acid Experimental Phase 4 110-16-7 444266
46
Lactitol Investigational Phase 4,Not Applicable 585-86-4 3871
47 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
48 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
49 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
50 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 465)
# Name Status NCT ID Phase Drugs
1 Flucinolone Acetonide Implant for Treating Refractory Ocular Behcet's Disease Unknown status NCT00720928 Phase 4 flucinolone acetonide
2 Posterior Subtenon Versus Intravitreal Injection of Triamcinolone Acetonide for Treatment of Uveitic Cystoid Macular Edema Unknown status NCT02598869 Phase 4 Triamcinolone Acetonide
3 Efficacy Comparison Study of Steroids to Control Post-operative Inflammation Unknown status NCT01801774 Phase 4 Subtenon 20-mg triamcinolone injection;Placebo
4 The Efficacy of Methylprednisolone in the Treatment of Patients With Ocular Involvement in Behcet's Disease Unknown status NCT01306955 Phase 4 methylorednisolone
5 Ozurdex Versus Ranibizumab Versus Combination for Central Retinal Vein Occlusion Unknown status NCT01827722 Phase 4 Ozurdex;Ranibizumab;Combination Ozurdex with Ranibizumab PRN
6 Effects of Ranibizumab to Delay or Regression Non-proliferative Diabetic Retinopathy(NPDR) With DME Assessed by Microaneurysm Changes: A Pilot Study Unknown status NCT02834663 Phase 4 Lucentis
7 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
8 Multi Center Prospective Registry of Infliximab Use for Childhood Uveitis Completed NCT00589628 Phase 4 infliximab;infliximab
9 Multicenter Uveitis Steroid Treatment (MUST) Trial Completed NCT00132691 Phase 4 fluocinolone acetonide intraocular implant;oral corticosteroid with immunosuppressive agents as needed
10 Re-implantation of a Fluocinolone Acetonide Implant for Non-infectious Uveitis Affecting the Posterior Segment Completed NCT00543296 Phase 4 0.59 mg Fluocinolone Acetonide implant
11 TAHOE: Intravitreal Dexamethasone Implant (Ozurdex) for Uveitic Macular Edema Completed NCT01870440 Phase 4 Ozurdex Intravitreal Injection (0.7 mg)
12 The Incidence of Extra-Articular Manifestations in Participants With Ankylosing Spondylitis Treated With Golimumab (MK-8259-012) Completed NCT01668004 Phase 4
13 A Study to Compare Ocular Safety and Tolerability of Eye Drops Containing Prednisolone Acetate in Patients With Intraocular Inflammation After Cataract Surgery Completed NCT00170729 Phase 4 Prednisolone acetate
14 Blood-aqueous Barrier Changes After the Use of Timolol and Prostaglandin Analogues Fixed Combination in Pseudophakic Patients With POAG Completed NCT01978015 Phase 4 travoprost and timolol maleate fixed combination;latanoprost and maleate timolol fixed combination;bimatoprost and timolol maleate fixed combination;dextran and hypromellose
15 Micropulse Laser Trabeculoplasty (MLT) Versus Selective Laser Trabeculoplasty (SLT) for Treatment of Open Angle Glaucoma Completed NCT01956942 Phase 4
16 Steroids After Laser Trabeculoplasty for Glaucoma Completed NCT00981435 Phase 4 Prednisolone 1%;Ketorolac;Artificial Tears
17 The Effects of BAK on the Blood Aqueous Barrier of Pseudophakic Patients Completed NCT01280110 Phase 4 Hydroxypropylmethylcellulose;Carboxymethylcellulose
18 Evaluation of Dosing Interval of Higher Doses of Ranibizumab Completed NCT00533520 Phase 4 ranibizumab
19 Aqueous Flare of a Hydrophobic Acrylic Single-piece Open-loop IOL With Modified Material Surface Properties Completed NCT01767012 Phase 4
20 Infliximab for the Prevention of Recurrent Crohn's Disease After Surgery Completed NCT00688636 Phase 4 infliximab;placebo
21 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) Completed NCT02059655 Phase 4 Bimatoprost;Eye drop solution
22 A Study Treating Participants With Early Axial Spondyloarthritis (axSpA) Taking an Intense Treatment Approach Versus Routine Treatment Completed NCT02897115 Phase 4
23 Intravitreal Aflibercept Injection for the Treatment of Submacular Vascularized Pigment Epithelial Detachment Completed NCT01722656 Phase 4 Aflibercept
24 Saline vs. Lactated Ringers for Emergency Department IV Fluid Resuscitation Completed NCT03133767 Phase 4 Lactated Ringer Solution;Normal Saline 0.9% Infusion Solution Bag
25 A Two Chemoprophylaxis Approaches After Phacoemulsification Surgery Completed NCT03634852 Phase 4 Moxifloxacin hydrochloride 0.5% eye drops;Dexamethasone 0.1% eye drops;Intracameral Moxifloxacin 0.1%;Subconjunctival Triamcinolone acetonide 4 mg /0.4 ml
26 Study of the Effectiveness of Ozurdex for the Control of Uveitis Recruiting NCT02049476 Phase 4 Dexamethasone pellet
27 Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis Recruiting NCT02943057 Phase 4 2% guttae ganciclovir
28 Efficacy and Safety of H.P. Acthar® Gel in Subjects With Severe Noninfectious Intermediate Uveitis, Posterior Uveitis, or Panuveitis NIPPU Recruiting NCT03656692 Phase 4 Acthar
29 Macular Edema Nepafenac vs. Difluprednate Uveitis Trial Recruiting NCT01939691 Phase 4 Difluprednate;Nepafenac;Prednisolone acetate
30 A Study to Assess the Effects of Certolizumab Pegol on the Reduction of Anterior Uveitis (AU) Flares in Axial Spondyloarthritis Subjects With a Documented History of AU Active, not recruiting NCT03020992 Phase 4 Certolizumab Pegol
31 Efficacy and Safety of H.P. ACTHAR GEL in Adults With Retinal Vasculitis Active, not recruiting NCT03066869 Phase 4 H.P. ACTHAR GEL
32 Effect of Intracameral Dexamethasone After Phacoemulsification in Diabetics on Corneal Endothelial Cell Density Not yet recruiting NCT03361709 Phase 4 Dexamethasone;Saline Solutions, Intraocular
33 Open Label Study of Acthar SQ Gel Injection in Patients With Active Anterior Uveitis Terminated NCT02769702 Phase 4 Acthar
34 Use of Thalidomide in Chronic Uveitis Terminated NCT00314665 Phase 4 Thalidomide
35 Efficacy Study of Methotrexate to Treat Sarcoid-associated Uveitis Terminated NCT00918554 Phase 4 Methotrexate;Placebo
36 Combination OZURDEX® & LUCENTIS® vs. OZURDEX® Monotherapy in Incomplete-Responders With Diabetic Macular Edema Terminated NCT02684084 Phase 4 Ozurdex;Lucentis
37 Methotrexate in the Treatment of Axial Spondyloarthritis Withdrawn NCT00298012 Phase 4 Methotrexate
38 Adalimumab in Uveitis Refractory to Conventional Therapy (ADUR Trial) Unknown status NCT00348153 Phase 2, Phase 3 Adalimumab
39 The Safety and Efficacy of a Tumor Necrosis Factor Receptor Fusion Protein on Uveitis Associated With Juvenile Rheumatoid Arthritis Unknown status NCT00012506 Phase 3 TNFR:Fc
40 Collaborative Ocular Melanoma Study (COMS) Unknown status NCT00000124 Phase 3
41 Topical Dexamethasone - Cyclodextrin Microparticle Eye Drops for Diabetic Macular Edema Unknown status NCT01523314 Phase 2, Phase 3 dexamethasone - Cyclodextrin eye drops
42 Evaluation of Seelens AF, an Aspheric Intra-Ocular Lens Unknown status NCT00825747 Phase 3
43 To Compare Intravitreal Clindamycin & Dexamethasone With Classic Treatment of Toxoplasmic Retinochoroiditis Unknown status NCT00372294 Phase 3 pyrimethamine-sulfadiazine + prednisolone;Clindamycin+Dexamethasone
44 A Study of Strontium90 Beta Radiation With Lucentis to Treat Age-Related Macular Degeneration Unknown status NCT00454389 Phase 3 ranibizumab
45 A Study of the Long-term Safety and Efficacy of Adalimumab in Subjects With Intermediate-, Posterior-, or Pan-uveitis Completed NCT01148225 Phase 3 adalimumab
46 Efficacy and Safety of Adalimumab in Subjects With Inactive Uveitis Completed NCT01124838 Phase 3 Adalimumab;Prednisone;Placebo
47 Effect of Adalimumab for the Treatment of Uveitis in Juvenile Idiopathic Arthritis Completed NCT01385826 Phase 2, Phase 3 Anti-tumor necrosis factor alpha monoclonal antibody;placebo
48 Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution in Non-Infectious Anterior Uveitis Completed NCT02517619 Phase 3 Dexamethasone Phosphate Ophthalmic Solution;Prednisolone Acetate Ophthalmic (1%)
49 First-line Antimetabolites as Steroid-sparing Treatment Uveitis Pilot Trial Completed NCT01232920 Phase 3 Methotrexate;Mycophenolate mofetil
50 Safety and Efficacy Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution to Treat Non-Infectious Anterior Segment Uveitis Completed NCT01505088 Phase 3 40 mg/mL Dexamethasone phosphate ophthalmic solution;Prednisolone Acetate (1%) Eyedrops;100 mM sodium citrate buffer solution;Placebo Eyedrops

Search NIH Clinical Center for Uveitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: uveitis

Genetic Tests for Uveitis

Genetic tests related to Uveitis:

# Genetic test Affiliating Genes
1 Uveitis 29

Anatomical Context for Uveitis

MalaCards organs/tissues related to Uveitis:

41
Eye, T Cells, Endothelial, Retina, Testes, Lung, Bone

Publications for Uveitis

Articles related to Uveitis:

(show top 50) (show all 3692)
# Title Authors Year
1
Presumed tuberculous uveitis in a university-based tertiary referral center in Saudi Arabia. ( 29318438 )
2018
2
Inflammatory bowel disease and acute anterior uveitis, but not psoriasis are associated with disease duration in Axial SpA: results from the (Be)Giant and ASPECT cohort. ( 29740978 )
2018
3
DETECTION OF TYPE 1 CHOROIDAL NEOVASCULAR MEMBRANES USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN TUBERCULAR POSTERIOR UVEITIS. ( 29689028 )
2018
4
Early treatment of tuberculous uveitis improves visual outcome: a 10-year cohort study. ( 29869018 )
2018
5
Diagnosis of Cytomegalovirus Anterior Uveitis in Two European Referral Centers. ( 29377783 )
2018
6
The pathogenic role of dendritic cells in non-infectious anterior uveitis. ( 29763582 )
2018
7
Management of Uveitis in Spondyloarthropathy: Current Trends. ( 29272246 )
2018
8
Superficial and deep retinal foveal avascular zone OCTA findings of non-infectious anterior and posterior uveitis. ( 29980918 )
2018
9
Increased Circulating Proinflammatory T Lymphocytes in Children with Different Forms of Anterior Uveitis: Results from a Pilot Study. ( 29771573 )
2018
10
Optimising drug therapy for non-infectious uveitis. ( 29961190 )
2018
11
Need for Quantitative Measurement Methods for Posterior Uveitis: Comparison of Dual FA/ICGA Angiography, EDI-OCT Choroidal Thickness and SUN Vitreous Haze Evaluation in Stromal Choroiditis. ( 29669371 )
2018
12
Bevacizumab Diminishes Inflammation in an Acute Endotoxin-Induced Uveitis Model. ( 29971005 )
2018
13
Recurrent anterior uveitis and subsequent incidence of ankylosing spondylitis: a nationwide cohort study from 2002 to 2013. ( 29415753 )
2018
14
Safety and Efficacy of Adalimumab in Patients with Noninfectious Uveitis in an Ongoing Open-Label Study: VISUAL III. ( 29429764 )
2018
15
Uveitis and internuclear ophthalmoplegia as ocular manifestations of sarcoidosis. ( 29942190 )
2018
16
A study of the key genes and inflammatory signaling pathways involved in HLA-B27-associated acute anterior uveitis families. ( 29620146 )
2018
17
Clinical Characteristics of Herpes Simplex Virus Associated Anterior Uveitis. ( 29345511 )
2018
18
Familial Blau syndrome without uveitis caused by a novel mutation in the nucleotide-binding oligomerization domain-containing protein 2 gene with good response to infliximab. ( 29570830 )
2018
19
Mosquito-Borne Uveitis. ( 29969369 )
2018
20
Elevated interleukin 37 expression associated with disease activity in HLA-B27 associated anterior uveitis and idiopathic anterior uveitis. ( 29424310 )
2018
21
Cyclophosphamide or Rituximab Treatment of Scleritis and Uveitis for Patients with Granulomatosis with Polyangiitis. ( 29635229 )
2018
22
Complications in Intermediate Uveitis: Prevalence, Time of Onset, and Effects on Vision in Short-Term and Long-Term Follow-Up. ( 29370567 )
2018
23
Childhood Arthritis and Rheumatology Research Alliance consensus treatment plans for juvenile idiopathic arthritis-associated and idiopathic chronic anterior uveitis. ( 29806733 )
2018
24
Efficacy and Safety of Mycophenolate Mofetil in the Treatment of Recalcitrant Intermediate Uveitis. ( 29652198 )
2018
25
Fever of unknown origin, bilateral sensorineural hearing loss with canal paresis and uveitis with iridocyclitis and episcleritis: a case of Cogan's syndrome. ( 29703835 )
2018
26
Association of genetic variants in<i>RAB23</i>and<i>ANXA11</i>with uveitis in sarcoidosis. ( 29416296 )
2018
27
Association of IL33 and IL1RAP polymorphisms with acute anterior uveitis. ( 29424312 )
2018
28
Clinical Features of CMV-Associated Anterior Uveitis. ( 29172842 )
2018
29
Macular Edema in Childhood Uveitis. ( 29452454 )
2018
30
Catching the therapeutic window of opportunity in early initial-onset Vogt-Koyanagi-Harada uveitis can cure the disease. ( 29948499 )
2018
31
Editorial: Uveitis: Pathology, Molecular Mechanisms and Therapy. ( 29424309 )
2018
32
Immunopathology of Virus-Induced Anterior Uveitis. ( 29543540 )
2018
33
Different composition of intraocular immune mediators in Posner-Schlossman-Syndrome and Fuchs' Uveitis. ( 29944680 )
2018
34
Tubulointerstitial nephritis and uveitis syndrome in children: report of three cases. ( 29944160 )
2018
35
Scleroderma &amp;quot;en coup de sabre&amp;quot; With Epilepsy and Uveitis Successfully Treated With Tocilizumab. ( 29929808 )
2018
36
An Intraocular Inflammatory Profile of Rubella Associated Uveitis. ( 29370571 )
2018
37
A case of conjunctival ulcer and uveitis caused byA AcrophialophoraA sp. in an immunocompromised patient; a case report and literature review. ( 29962481 )
2018
38
Hypertensive acute granulomatous anterior uveitis as a side effect of topical brimonidine. ( 29910082 )
2018
39
Necrotising scleritis, keratitis and uveitis in primary antiphospholipid syndrome. ( 29764818 )
2018
40
Tonic Pupil in Cytomegalovirus Anterior Uveitis in an Immunocompetent Adult Male - A Case Report. ( 29028408 )
2018
41
Multiplex Cytokine Analysis of Aqueous Humor in Juvenile Idiopathic Arthritis-Associated Anterior Uveitis With or Without Secondary Glaucoma. ( 29675026 )
2018
42
Efficacy of Natalizumab in Intermediate Uveitis Related to Multiple Sclerosis: A Case Report. ( 29452449 )
2018
43
Cataract surgery combined with micro-incision vitrectomy in patients with behcet's disease uveitis. ( 29954349 )
2018
44
Contribution of diagnostic tests for the etiological assessment of uveitis, data from the ULISSE study (Uveitis: Clinical and medicoeconomic evaluation of a standardized strategy of the etiological diagnosis). ( 29427823 )
2018
45
Reply to: &amp;quot;Crowell et al. Idiopathic Central Nervous System Inflammatory Disease in the Setting of HLA-B27 Uveitis&amp;quot;. ( 29958047 )
2018
46
The Syndrome of Tubulointerstitial Nephritis With Uveitis (TINU). ( 29429748 )
2018
47
A Cross-Sectional Observational Study of Nailfold Capillary Morphology in Uveitis. ( 29966450 )
2018
48
Novel microsurgical management of uveitis-glaucoma-hyphema syndrome. ( 29943072 )
2018
49
Prevalence of axial spondyloarthritis in patients with acute anterior uveitis: a cross-sectional study utilising MRI. ( 29531779 )
2018
50
Granulomatous Tattoo reaction with Associated Uveitis successfully treated with methotrexate. ( 29419907 )
2018

Variations for Uveitis

Expression for Uveitis

Search GEO for disease gene expression data for Uveitis.

Pathways for Uveitis

Pathways related to Uveitis according to GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.11 CCL2 CTLA4 HLA-B ICAM1 IFNA2 IFNG
2
Show member pathways
13.93 CAPN5 CCL2 CXCR3 IL10 IL17A IL1A
3
Show member pathways
13.75 CCL2 CXCR3 IFNA2 IFNG IL10 IL17A
4
Show member pathways
13.61 CCL2 ICAM1 IFNA2 IFNG IL10 IL17A
5
Show member pathways
13.51 CCL2 CXCR3 IL10 IL17A IL1A IL1R1
6
Show member pathways
13.38 CCL2 CXCR3 IL10 IL17A IL1A IL1R1
7
Show member pathways
13.38 CCL2 HLA-B ICAM1 IFNA2 IFNG IL10
8
Show member pathways
13.13 CCL2 HLA-B ICAM1 IFNA2 IL1R1 TGFB2
9
Show member pathways
13.1 CCL2 IFNA2 IFNG IL10 NOD2 TGFB2
10
Show member pathways
12.91 CTLA4 HLA-B ICAM1 IFNA2 IFNG IL10
11
Show member pathways
12.89 CCL2 HLA-B ICAM1 IFNA2 IFNG IL1A
12 12.86 IFNA2 IFNG IL2RA IL4 TGFB2
13
Show member pathways
12.69 IFNG IL10 IL2RA IL4 TNF
14
Show member pathways
12.65 CCL2 IFNG IL10 IL17A TNF
15 12.64 CCL2 CTLA4 IFNG IL10 IL17A IL2RA
16
Show member pathways
12.63 HLA-B ICAM1 IFNA2 IFNG IL4 TNF
17
Show member pathways
12.56 IFNG IL10 IL17A IL1A IL1R1 IL2RA
18 12.55 HLA-B ICAM1 IL1R1 IL2RA TGFB2 TNF
19
Show member pathways
12.54 CTLA4 IFNG IL10 IL17A IL1A IL4
20
Show member pathways
12.48 IFNA2 IFNG IL10 IL2RA IL4
21
Show member pathways
12.47 CAPN5 IL1A IL1R1 IL2RA
22
Show member pathways
12.43 CCL2 ICAM1 IFNG IL4 TNF
23
Show member pathways
12.43 CCL2 IFNG IL17A IL4 TNF
24
Show member pathways
12.38 IFNG IL10 IL1A IL4 TGFB2 TNF
25
Show member pathways
12.35 CCL2 IL1A IL1R1 NOD2
26 12.35 IFNA2 IFNG IL10 IL1A NOD2 TGFB2
27
Show member pathways
12.34 IFNG IL1A IL1R1 TNF
28 12.34 HLA-B ICAM1 IFNA2 TNF
29
Show member pathways
12.27 IFNA2 IFNG IL1A TNF
30
Show member pathways
12.25 IFNG IL1R1 IL4 TNF
31 12.22 CCL2 ICAM1 IFNG IL1A IL1R1 TNF
32 12.17 IFNG IL1A IL1R1 TGFB2 TNF
33
Show member pathways
12.17 IFNG IL10 IL17A IL1R1 TGFB2 TNF
34
Show member pathways
12.17 HLA-B IFNA2 IFNG IL10 IL17A IL1A
35 12.15 CCL2 ICAM1 IFNG IL1A IL1R1 IL4
36 12.11 IFNA2 IFNG IL10 IL2RA IL4 TNF
37 12.11 CCL2 ICAM1 IL10 IL17A IL1A IL4
38
Show member pathways
12.08 CCL2 ICAM1 IFNG IL10 IL17A IL1A
39
Show member pathways
12.06 IFNG IL1R1 IL2RA IL4
40 12.05 CCL2 ICAM1 NOD2 TNF
41 12.04 CCL2 ICAM1 IL1A TGFB2 TNF
42 12.03 IL1A IL1R1 IL2RA IL4 TNF
43 12.02 IFNG IL10 IL1R1 TGFB2 TNF
44 11.96 IFNA2 IFNG IL10 IL2RA
45 11.9 ICAM1 IL1R1 TNF
46
Show member pathways
11.88 CTLA4 IFNG IL2RA IL4 TNF
47 11.86 IFNA2 IFNG IL10 TNF
48 11.84 IFNG TGFB2 TNF
49 11.83 ICAM1 IFNG IL4
50 11.8 IL10 IL1A TNF

GO Terms for Uveitis

Cellular components related to Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.9 CCL2 ICAM1 IFNA2 IFNG IL10 IL17A
2 cell surface GO:0009986 9.56 CAPN5 CXCR3 HLA-B ICAM1 IL1R1 IL2RA
3 external side of plasma membrane GO:0009897 9.17 CTLA4 CXCR3 ICAM1 IL17A IL1R1 IL2RA
4 extracellular region GO:0005576 10 CCL2 IFNA2 IFNG IL10 IL17A IL1A

Biological processes related to Uveitis according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.97 IFNA2 IFNG TGFB2 TNF
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.97 CCL2 ICAM1 NOD2 TNF
3 cell surface receptor signaling pathway GO:0007166 9.87 CCL2 CXCR3 IFNA2 IFNG IL1R1 IL2RA
4 inflammatory response GO:0006954 9.86 CCL2 CXCR3 IFNA2 IL10 IL17A IL1A
5 cellular response to interleukin-1 GO:0071347 9.85 CCL2 ICAM1 IL17A
6 B cell differentiation GO:0030183 9.84 IFNA2 IL10 IL4
7 cellular response to organic cyclic compound GO:0071407 9.83 CCL2 NOD2 TNF
8 interferon-gamma-mediated signaling pathway GO:0060333 9.83 HLA-B ICAM1 IFNG
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.83 IFNA2 IFNG IL4
10 regulation of inflammatory response GO:0050727 9.82 IL1R1 NOD2 TNF
11 regulation of signaling receptor activity GO:0010469 9.81 CCL2 IFNA2 IFNG IL10 IL17A IL1A
12 cellular response to lipopolysaccharide GO:0071222 9.8 CCL2 ICAM1 IL10 NOD2 TNF
13 interleukin-1-mediated signaling pathway GO:0070498 9.79 IL1A IL1R1 NOD2
14 extrinsic apoptotic signaling pathway GO:0097191 9.78 IFNG TGFB2 TNF
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 ICAM1 IFNG TNF
16 negative regulation of T cell proliferation GO:0042130 9.75 CTLA4 IL10 IL2RA
17 negative regulation of endothelial cell apoptotic process GO:2000352 9.74 ICAM1 IL10 IL4
18 positive regulation of cytokine secretion GO:0050715 9.69 IL10 IL1A TNF
19 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.68 CCL2 NOD2
20 humoral immune response GO:0006959 9.67 CCL2 IFNA2 IFNG TNF
21 positive regulation of osteoclast differentiation GO:0045672 9.65 IFNG IL17A TNF
22 cytokine-mediated signaling pathway GO:0019221 9.65 CCL2 ICAM1 IFNA2 IL10 IL17A IL1A
23 endothelial cell apoptotic process GO:0072577 9.64 IL10 TNF
24 positive regulation of MHC class II biosynthetic process GO:0045348 9.64 IL10 IL4
25 negative regulation of cytokine secretion involved in immune response GO:0002740 9.63 IL10 TNF
26 regulation of regulatory T cell differentiation GO:0045589 9.63 CTLA4 IFNG IL2RA
27 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.62 ICAM1 TNF
28 positive regulation of interleukin-23 production GO:0032747 9.61 IFNG IL17A
29 negative regulation of immune response GO:0050777 9.61 CTLA4 IL2RA TGFB2
30 regulation of isotype switching GO:0045191 9.59 IL10 IL4
31 type 2 immune response GO:0042092 9.58 IL10 IL4
32 negative regulation of alkaline phosphatase activity GO:0010693 9.56 TGFB2 TNF
33 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.55 IFNG TNF
34 receptor biosynthetic process GO:0032800 9.54 IL10 TNF
35 regulation of complement-dependent cytotoxicity GO:1903659 9.52 IL10 TGFB2
36 positive regulation of vitamin D biosynthetic process GO:0060557 9.49 IFNG TNF
37 immune response GO:0006955 9.4 CCL2 CTLA4 CXCR3 HLA-B IFNG IL10
38 apoptotic process GO:0006915 10.11 CXCR3 IFNA2 IFNG IL17A IL1A IL2RA

Molecular functions related to Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 CCL2 IFNA2 IFNG IL10 IL17A IL1A

Sources for Uveitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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