MCID: UVP001
MIFTS: 29

Uveoparotid Fever

Categories: Immune diseases

Aliases & Classifications for Uveoparotid Fever

MalaCards integrated aliases for Uveoparotid Fever:

Name: Uveoparotid Fever 12 44 15 73
Heerfordt's Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13404
ICD10 33 D86.89
MeSH 44 D014608
SNOMED-CT 68 31541009 4416007
UMLS 73 C0042171

Summaries for Uveoparotid Fever

MalaCards based summary : Uveoparotid Fever, also known as heerfordt's syndrome, is related to facial paralysis and cerebral sarcoidosis. An important gene associated with Uveoparotid Fever is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Interleukin-4 and 13 signaling and Adipocytokine signaling pathway. Affiliated tissues include eye, skin and heart, and related phenotypes are adipose tissue and endocrine/exocrine gland

Wikipedia : 76 Heerfordt syndrome, also referred to as uveoparotid fever,Heerfordt�??Mylius syndrome,... more...

Related Diseases for Uveoparotid Fever

Diseases related to Uveoparotid Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 facial paralysis 10.1
2 cerebral sarcoidosis 10.1 ACE LYZ
3 loeffler syndrome 10.1 ACE ENSG00000264813
4 autoimmune atherosclerosis 10.1 ACE ENSG00000264813
5 fiedler's myocarditis 10.1 ACE ENSG00000264813
6 orthostatic proteinuria 10.1 ACE ENSG00000264813
7 malignant essential hypertension 10.1 ACE ENSG00000264813
8 neuroretinitis 10.1 ACE LYZ
9 subdural empyema 10.1 ACE ENSG00000264813
10 subacute cutaneous lupus erythematosus 10.1 ACE TNF
11 skin sarcoidosis 10.1 ACE TNF
12 granulomatous dermatitis 10.1 ACE TNF
13 posterior urethral valves 10.1 ACE TNF
14 renal tuberculosis 10.1 ENSG00000264813 LYZ
15 ischemic heart disease 10.0 ACE TNF
16 melkersson-rosenthal syndrome 10.0 ACE TNF
17 extrinsic cardiomyopathy 10.0 ACE TNF
18 rheumatic heart disease 10.0 ACE TNF
19 microscopic colitis 10.0 LYZ TNF
20 pyelonephritis 10.0 ACE TNF
21 periodic fever, familial, autosomal dominant 10.0 LYZ TNF
22 limb ischemia 10.0 ACE TNF
23 silicosis 10.0 ACE TNF
24 acute salpingitis 10.0 LYZ TNF
25 carotid stenosis 10.0 ACE TNF
26 adult respiratory distress syndrome 10.0 ACE TNF
27 tuberculous meningitis 10.0 LYZ TNF
28 meningitis 10.0 LYZ TNF
29 pulmonary sarcoidosis 10.0 ACE TNF
30 lymphangiosarcoma 10.0 LYZ TNF
31 pulmonary edema 10.0 ACE TNF
32 lymphatic system disease 10.0 LYZ TNF
33 sleep apnea 10.0 ACE TNF
34 end stage renal failure 10.0 ACE TNF
35 vascular dementia 10.0 ACE TNF
36 hypoaldosteronism 10.0 ACE POMC
37 syndrome of inappropriate antidiuretic hormone 10.0 ACE POMC
38 immune system disease 10.0 ACE TNF
39 membranous nephropathy 10.0 ACE TNF
40 chagas disease 10.0 ACE TNF
41 cutaneous solitary mastocytoma 10.0 LYZ POMC
42 laryngeal tuberculosis 10.0 LYZ POMC
43 respiratory failure 9.9 ACE TNF
44 hypokalemia 9.9 ACE POMC
45 nodular nonsuppurative panniculitis 9.9 LYZ POMC
46 sarcoidosis 1 9.9 ACE TNF
47 cerebrovascular disease 9.9 ACE TNF
48 nervous system disease 9.9 ACE TNF
49 arteries, anomalies of 9.9 ACE ENSG00000264813 TNF
50 pancreas disease 9.9 POMC TNF

Graphical network of the top 20 diseases related to Uveoparotid Fever:



Diseases related to Uveoparotid Fever

Symptoms & Phenotypes for Uveoparotid Fever

MGI Mouse Phenotypes related to Uveoparotid Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.56 ACE LYZ POMC TNF
2 endocrine/exocrine gland MP:0005379 9.46 ACE LYZ POMC TNF
3 liver/biliary system MP:0005370 9.26 ACE LYZ POMC TNF
4 neoplasm MP:0002006 8.92 ACE LYZ POMC TNF

Drugs & Therapeutics for Uveoparotid Fever

Search Clinical Trials , NIH Clinical Center for Uveoparotid Fever

Cochrane evidence based reviews: uveoparotid fever

Genetic Tests for Uveoparotid Fever

Anatomical Context for Uveoparotid Fever

MalaCards organs/tissues related to Uveoparotid Fever:

41
Eye, Skin, Heart, Pancreas

Publications for Uveoparotid Fever

Articles related to Uveoparotid Fever:

(show all 20)
# Title Authors Year
1
Two Cases of Heerfordt's Syndrome: A Rare Manifestation of Sarcoidosis. ( 26885424 )
2016
2
Heerfordt's Syndrome Associated with a High Fever and Elevation of TNF-α. ( 27549672 )
2016
3
Heerfordt's Syndrome Presenting with Recurrent Facial Nerve Palsy: Case report and 10-year literature review. ( 25685372 )
2015
4
Heerfordt's Syndrome: An interesting and under-recognised manifestation of sarcoidosis. ( 25685388 )
2015
5
Heerfordt's syndrome. ( 26370758 )
2015
6
Images in clinical medicine. Heerfordt's syndrome, or uveoparotid fever. ( 23902485 )
2013
7
HLA-DRB1* alleles and symptoms associated with Heerfordt's syndrome in sarcoidosis. ( 21565911 )
2011
8
Nodular cystic fat necrosis in Heerfordt's syndrome. ( 17448005 )
2007
9
Diagnosis of Heerfordt's syndrome by state-of-the-art ultrasound in combination with parotid biopsy: a case report. ( 11868089 )
2002
10
Sarcoidosis presenting as Heerfordt's syndrome with myopathy. ( 11491515 )
2001
11
Facial palsy in Heerfordt's syndrome: electrophysiological localization of the lesion. ( 10454727 )
1999
12
Uveoparotid fever. A case report. ( 2314772 )
1990
13
Facial paresis after general anesthesia. Report of an unusual case: Heerfordt's syndrome. ( 3963459 )
1986
14
Heerfordt's syndrome presenting with an erythematous eruption of the lower legs. ( 4044961 )
1985
15
Heerfordt's syndrome in two sisters. ( 1212577 )
1975
16
FACIAL PALSY IN HEERFORDT'S SYNDROME. ( 14193237 )
1964
17
Facial paralysis in the uveoparotid fever of Boeck's sarcoid. ( 13411990 )
1957
18
Heerfordt's syndrome. ( 13077677 )
1953
19
Uveoparotid fever: Heerfordt's disease. ( 14810867 )
1951
20
Uveoparotid fever. ( 14873509 )
1951

Variations for Uveoparotid Fever

Expression for Uveoparotid Fever

Search GEO for disease gene expression data for Uveoparotid Fever.

Pathways for Uveoparotid Fever

Pathways related to Uveoparotid Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.01 POMC TNF
2 10.46 POMC TNF

GO Terms for Uveoparotid Fever

Cellular components related to Uveoparotid Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.26 ACE LYZ POMC TNF
2 extracellular space GO:0005615 9.02 ACE ENSG00000264813 LYZ POMC TNF

Biological processes related to Uveoparotid Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 9.26 LYZ TNF
2 regulation of blood pressure GO:0008217 9.16 ACE POMC
3 positive regulation of blood pressure GO:0045777 8.96 ACE ENSG00000264813
4 positive regulation of systemic arterial blood pressure GO:0003084 8.62 ACE ENSG00000264813

Molecular functions related to Uveoparotid Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carboxypeptidase activity GO:0004180 9.26 ACE ENSG00000264813
2 dipeptidyl-peptidase activity GO:0008239 9.16 ACE ENSG00000264813
3 exopeptidase activity GO:0008238 8.96 ACE ENSG00000264813
4 peptidyl-dipeptidase activity GO:0008241 8.62 ACE ENSG00000264813

Sources for Uveoparotid Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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