MCID: UVP001
MIFTS: 35

Uveoparotid Fever

Categories: Endocrine diseases, Immune diseases, Neuronal diseases

Aliases & Classifications for Uveoparotid Fever

MalaCards integrated aliases for Uveoparotid Fever:

Name: Uveoparotid Fever 12 44 15 17 70
Heerfordt's Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13404
MeSH 44 D014608
SNOMED-CT 67 31541009
ICD10 32 D86.89
UMLS 70 C0042171

Summaries for Uveoparotid Fever

Disease Ontology : 12 A sarcoidosis that is characterized by unilateral facial nerve palsy, parotid gland enlargement, anterior uveitis, and low grade fever, and develops from a type IV hypersensitivity reaction with noncaseating granulomatous infiltration of especially the parotid glands which compresses the facial nerve.

MalaCards based summary : Uveoparotid Fever, also known as heerfordt's syndrome, is related to neurosarcoidosis and iridocyclitis. An important gene associated with Uveoparotid Fever is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are NF-kappaB Signaling and Toll-Like receptor Signaling Pathways. Affiliated tissues include eye, lung and skin, and related phenotypes are hematopoietic system and endocrine/exocrine gland

Wikipedia : 73 Heerfordt syndrome is a rare manifestation of sarcoidosis. The symptoms include inflammation of the eye... more...

Related Diseases for Uveoparotid Fever

Diseases related to Uveoparotid Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 345)
# Related Disease Score Top Affiliating Genes
1 neurosarcoidosis 30.6 TNF CD8A CD4 ACE
2 iridocyclitis 30.5 TNF CD4 ACE
3 parotitis 30.4 SSB CD8A CD4
4 facial paralysis 30.4 TNF CD8A CD4 ACE
5 cardiac sarcoidosis 30.2 TNF IFNG ACE
6 pulmonary sarcoidosis 30.2 TNF IFNG ACE
7 cranial nerve palsy 30.2 POMC CD4 ACE
8 meningoencephalitis 30.1 TNF CD8A CD4 CARD9
9 skin sarcoidosis 30.0 TNF IFNG CD8A CD4 ACE
10 sarcoidosis 1 29.3 TNF NOD2 IFNG CHIT1 CD8A CD4
11 anterior scleritis 10.4 TNF ACE
12 posterior scleritis 10.4 TNF ACE
13 cork-handlers' disease 10.4 CD8A CD4
14 granulomatous myositis 10.4 CD8A ACE
15 early yaws 10.4 CD8A CD4
16 toxicodendron dermatitis 10.4 TNF CD8A
17 sigmoid disease 10.4 TNF NOD2
18 rheumatoid arthritis interstitial lung disease 10.4 TNF CD4
19 ventilation pneumonitis 10.4 CD8A CD4
20 latent syphilis 10.4 CD8A CD4
21 listeria meningitis 10.4 TNF CD8A
22 autoimmune lymphoproliferative syndrome, type iia 10.4 CD8A CD4
23 meningovascular neurosyphilis 10.4 TNF CD4
24 parapsoriasis 10.4 CD8A CD4
25 neuroretinitis 10.4 CD4 ACE
26 gastroduodenitis 10.3 CD8A CD4
27 gastroduodenal crohn's disease 10.3 TNF NOD2
28 primary syphilis 10.3 CD8A CD4
29 norwegian scabies 10.3 CD8A CD4
30 bird fancier's lung 10.3 CD8A CD4
31 pouchitis 10.3 TNF NOD2
32 brawny scleritis 10.3 IFNG ACE
33 optic papillitis 10.3 CD4 ACE
34 metal allergy 10.3 CD8A CD4
35 variola major 10.3 CD8A CD4
36 follicular mucinosis 10.3 CD8A CD4
37 spongiotic dermatitis 10.3 CD8A CD4
38 acute retinal necrosis syndrome 10.3 CD8A CD4
39 granuloma annulare 10.3 TNF CD4
40 posterior urethral valves 10.3 TNF ACE
41 staphylococcal toxic shock syndrome 10.3 TNF IFNG
42 autoimmune myocarditis 10.3 TNF IFNG
43 cerebral lymphoma 10.3 CD8A CD4
44 type 1 diabetes mellitus 23 10.3 TNF CD8A CD4
45 retinal vasculitis 10.3 TNF CD4 ACE
46 mediastinum teratoma 10.3 POMC ACE
47 spotted fever rickettsiosis 10.3 TNF IFNG
48 polyarticular juvenile idiopathic arthritis 10.3 TNF IFNG
49 tertiary syphilis 10.3 TNF CD8A CD4
50 cerebritis 10.3 TNF CD8A CD4

Graphical network of the top 20 diseases related to Uveoparotid Fever:



Diseases related to Uveoparotid Fever

Symptoms & Phenotypes for Uveoparotid Fever

MGI Mouse Phenotypes related to Uveoparotid Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.93 ACE ATG16L1 CARD9 CD4 CD8A IFNG
2 endocrine/exocrine gland MP:0005379 9.91 ACE ATG16L1 CD4 CD8A IFNG POMC
3 homeostasis/metabolism MP:0005376 9.73 ACE ANXA11 ATG16L1 CARD9 CD4 IFNG
4 immune system MP:0005387 9.4 ACE ATG16L1 CARD9 CD4 CD8A CHIT1

Drugs & Therapeutics for Uveoparotid Fever

Search Clinical Trials , NIH Clinical Center for Uveoparotid Fever

Cochrane evidence based reviews: uveoparotid fever

Genetic Tests for Uveoparotid Fever

Anatomical Context for Uveoparotid Fever

MalaCards organs/tissues related to Uveoparotid Fever:

40
Eye, Lung, Skin, Salivary Gland, Lymph Node, Bone, Spinal Cord

Publications for Uveoparotid Fever

Articles related to Uveoparotid Fever:

(show top 50) (show all 68)
# Title Authors PMID Year
1
Sarcoidosis: A Clinical Overview from Symptoms to Diagnosis. 61
33807303 2021
2
Ocular sarcoidosis: clinical experience and recent pathogenetic and therapeutic advancements. 61
32740881 2020
3
Heerfordt's Syndrome Associated with Trigeminal Nerve Palsy and Reversed Halo Sign. 61
33390492 2020
4
Heerfordt-Waldenström Syndrome Manifesting as Cardiac Sarcoidosis. 61
32983747 2020
5
[Heerfordt's syndrome: about a case and literature review]. 61
33425150 2020
6
A Rare Case of Heerfordt's Syndrome with Bilateral Facial Palsy. 61
31750120 2019
7
Uveoparotid fever as a presentation of sarcoidosis. 61
31656441 2019
8
Leprosy or sarcoidosis? A diagnostic dilemma! 61
30598969 2018
9
Sarcoidosis with fever and a splenic infarct due to CMV or lymphoma? 61
28705467 2017
10
Neurosarcoidosis: a clinical approach to diagnosis and management. 61
27878437 2017
11
A Report of Two Cases of Solid Facial Edema in Acne. 61
28168623 2017
12
Heerfordt's Syndrome Associated with a High Fever and Elevation of TNF-α. 61
27549672 2016
13
Clinical and radiological features of extra-pulmonary sarcoidosis: a pictorial essay. 61
27222055 2016
14
Two Cases of Heerfordt's Syndrome: A Rare Manifestation of Sarcoidosis. 61
26885424 2016
15
Heerfordt's syndrome. 61
26370758 2015
16
Diagnosis of Sarcoidosis. 61
25779004 2015
17
Heerfordt's Syndrome: An interesting and under-recognised manifestation of sarcoidosis. 61
25685388 2015
18
Heerfordt's Syndrome Presenting with Recurrent Facial Nerve Palsy: Case report and 10-year literature review. 61
25685372 2015
19
The Heerfordt-Waldenström syndrome as an initial presentation of sarcoidosis. 61
24082416 2013
20
[Radiculopathy in patients with Heerfordt's syndrome: two case presentations and review of the literature]. 61
23917502 2013
21
Images in clinical medicine. Heerfordt's syndrome, or uveoparotid fever. 61
23902485 2013
22
[Castleman's disease : a rare differential diagnosis for Heerfordt's syndrome]. 61
22534680 2012
23
Rare manifestations of sarcoidosis in modern era of new diagnostic tools. 61
22771590 2012
24
HLA-DRB1* alleles and symptoms associated with Heerfordt's syndrome in sarcoidosis. 61
21565911 2011
25
[Case of Heerfordt's syndrome presenting polyneuropathy]. 61
21706840 2011
26
Nodular cystic fat necrosis in Heerfordt's syndrome. 61
17448005 2007
27
[Case of Heerfordt's syndrome with prolonged peripheral nerve involvement]. 61
17087344 2006
28
[A case of Heerfordt's syndrome with an elevated serum TNF alpha]. 61
17037408 2006
29
[Heerfordt's syndrome]. 61
15988349 2005
30
Bilateral Gasser's ganglion sarcoidosis: diagnosis, treatment and unsolved questions. 61
15881284 2005
31
[Heerfordt's syndrome -- a rare initial manifestation of sarcoidosis]. 61
15630597 2005
32
[Sarcoidosis, Löfgren's syndrome and uveoparotid fever]. 61
15498449 2004
33
[Use of state-of-the-art ultrasound techniques in diagnosing sarcoidosis of the salivary glands (Heerfordt's syndrome)]. 61
12835855 2003
34
Cardiac sarcoidosis presenting as Heerfordt's syndrome. 61
12015261 2002
35
Diagnosis of Heerfordt's syndrome by state-of-the-art ultrasound in combination with parotid biopsy: a case report. 61
11868089 2002
36
Sarcoidosis presenting as Heerfordt's syndrome with myopathy. 61
11491515 2001
37
[Clinical diagnosis of salivary gland sarcoidosis (Heerfordt syndrome)]. 61
10994173 2000
38
Parotid gland sarcoidosis. 61
10746259 2000
39
Facial palsy in Heerfordt's syndrome: electrophysiological localization of the lesion. 61
10454727 1999
40
[Heerfordt's syndrome remitting without corticosteroid therapy]. 61
9742871 1998
41
[Magnetic resonance sialography. A new diagnostic method for imaging salivary duct patency]. 61
9539054 1998
42
[67Ga scintigraphy in acute sarcoidosis with Heerfordt's syndrome]. 61
7724364 1995
43
[A case of sarcoidosis presenting with Heerfordt's syndrome, associated with hepatosplenomegaly, pleural effusion, and ascites]. 61
1405089 1992
44
Uveoparotid fever. A case report. 61
2314772 1990
45
[A case of Heerfordt's syndrome associated with acquired type II-b hyperlipoproteinemia, leading to the development of myocardial infarction during its clinical course]. 61
3204870 1988
46
Bilateral facial nerve palsy: a case study and literature review. 61
3560303 1987
47
Facial paresis after general anesthesia. Report of an unusual case: Heerfordt's syndrome. 61
3963459 1986
48
Heerfordt's syndrome presenting with an erythematous eruption of the lower legs. 61
4044961 1985
49
Sarcoidosis--the beginning: historical highlights of personalities and their accomplishments during the early years. 61
6387158 1984
50
Reversible facial paralysis in sarcoidosis. Confirmation by serum angiotensin-converting enzyme assay. 61
6314956 1983

Variations for Uveoparotid Fever

Expression for Uveoparotid Fever

Search GEO for disease gene expression data for Uveoparotid Fever.

Pathways for Uveoparotid Fever

GO Terms for Uveoparotid Fever

Biological processes related to Uveoparotid Fever according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 10 TRAF3 SERPING1 NOD2 IRGM CARD9
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.85 TNF NOD2 CD4 CCL18
3 positive regulation of protein phosphorylation GO:0001934 9.83 TNF IRGM IFNG CD4
4 defense response to Gram-positive bacterium GO:0050830 9.78 TNF NOD2 CARD9
5 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.78 TNF NOD2 CD4 CARD9
6 positive regulation of tumor necrosis factor production GO:0032760 9.76 NOD2 IFNG CARD9
7 immune response GO:0006955 9.73 TNF IFNG CHIT1 CD8A CD4 CCL18
8 positive regulation of autophagy GO:0010508 9.71 IRGM IFNG ATG16L1
9 immune system process GO:0002376 9.7 TRAF3 SERPING1 NOD2 IRGM CD8A CD4
10 positive regulation of interleukin-1 beta production GO:0032731 9.67 TNF NOD2 IFNG
11 positive regulation of phagocytosis GO:0050766 9.63 TNF NOD2 IFNG
12 response to muramyl dipeptide GO:0032495 9.59 NOD2 CARD9
13 negative regulation of amyloid-beta clearance GO:1900222 9.58 TNF IFNG
14 nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070431 9.57 NOD2 IRGM
15 response to peptidoglycan GO:0032494 9.56 NOD2 CARD9
16 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.51 TNF NOD2
17 protein lipidation involved in autophagosome assembly GO:0061739 9.43 IRGM ATG16L1
18 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.4 TNF IFNG
19 positive regulation of vitamin D biosynthetic process GO:0060557 9.37 TNF IFNG
20 positive regulation of nitrogen compound metabolic process GO:0051173 9.32 TNF IFNG
21 positive regulation of interleukin-6 production GO:0032755 9.26 TNF NOD2 IFNG CARD9
22 positive regulation of JNK cascade GO:0046330 8.92 TRAF3 TNF NOD2 CARD9

Molecular functions related to Uveoparotid Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CARD domain binding GO:0050700 8.8 NOD2 IRGM CARD9

Sources for Uveoparotid Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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