MCID: VGN011
MIFTS: 26

Vagina Leiomyosarcoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Vagina Leiomyosarcoma

MalaCards integrated aliases for Vagina Leiomyosarcoma:

Name: Vagina Leiomyosarcoma 12 15
Leiomyosarcoma of the Vagina 12
Vaginal Leiomyosarcoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5283
NCIt 49 C6326
UMLS 71 C1336940

Summaries for Vagina Leiomyosarcoma

Disease Ontology : 12 A vagina sarcoma that has material basis in smooth muscle.

MalaCards based summary : Vagina Leiomyosarcoma, also known as leiomyosarcoma of the vagina, is related to vaginal discharge and vaginal cancer. An important gene associated with Vagina Leiomyosarcoma is ADIRF (Adipogenesis Regulatory Factor). Affiliated tissues include breast, smooth muscle and lung, and related phenotypes are integument and no phenotypic analysis

Related Diseases for Vagina Leiomyosarcoma

Diseases related to Vagina Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 196)
# Related Disease Score Top Affiliating Genes
1 vaginal discharge 30.1 PGR ESR1
2 vaginal cancer 29.5 PGR ESR1 CALD1
3 leiomyoma 29.5 PGR KIT ESR1
4 leiomyosarcoma 28.2 PGR MYOG MLANA KIT ESR1
5 vagina sarcoma 27.1 PGR MYOG MLANA KIT ESR1 CALD1
6 lung combined type small cell carcinoma 10.2 MYOG CALD1
7 conventional leiomyosarcoma 10.2 MYOG CALD1
8 adult fibrosarcoma 10.2 MYOG CALD1
9 extraosseous osteosarcoma 10.2 MYOG CALD1
10 malignant mesenchymoma 10.2 MYOG CALD1
11 malignant choroid melanoma 10.2 MLANA ADIRF
12 rare tumor 10.2
13 breast myofibroblastoma 10.2 ESR1 CALD1
14 glomangiosarcoma 10.2 MLANA CALD1
15 ovarian melanoma 10.2 MLANA CALD1
16 uterus perivascular epithelioid cell tumor 10.2 MLANA CALD1
17 benign perivascular tumor 10.2 MLANA CALD1
18 dermis tumor 10.2 MLANA CALD1
19 myxosarcoma 10.2 MLANA CALD1
20 pseudosarcomatous fibromatosis 10.2 MYOG CALD1
21 infiltrating angiolipoma 10.2 MLANA CALD1
22 infantile myofibromatosis 10.2 MYOG CALD1
23 ovarian mesodermal adenosarcoma 10.2 MYOG ESR1
24 olfactory nerve neoplasm 10.1 MYOG MLANA
25 pulmonary vein leiomyosarcoma 10.1 PGR CALD1
26 cranial nerve malignant neoplasm 10.1 MYOG MLANA
27 vagina leiomyoma 10.1 PGR CALD1
28 cranial nerve neoplasm 10.1 MYOG MLANA
29 peritoneal benign neoplasm 10.1 PGR CALD1
30 vaginal benign neoplasm 10.1 PGR CALD1
31 glassy cell carcinoma of the cervix 10.0 PGR ESR1
32 bartholin's gland adenoid cystic carcinoma 10.0 PGR ESR1
33 chronic tympanitis 10.0 PGR ESR1
34 bartholin's gland adenoma 10.0 PGR ESR1
35 granulomatous endometritis 10.0 PGR ESR1
36 endometritis 10.0 PGR ESR1
37 bartholin's gland benign neoplasm 10.0 PGR ESR1
38 vestibular gland benign neoplasm 10.0 PGR ESR1
39 breast juvenile papillomatosis 10.0 PGR ESR1
40 vulvar syringoma 10.0 PGR ESR1
41 trigonitis 10.0 PGR ESR1
42 breast scirrhous carcinoma 10.0 PGR ESR1
43 cervical serous adenocarcinoma 10.0 PGR MLANA
44 oncocytic breast carcinoma 10.0 PGR ESR1
45 ovarian seromucinous carcinoma 10.0 PGR ESR1
46 breast papillary carcinoma 10.0 PGR ESR1
47 breast leiomyoma 10.0 PGR ESR1
48 comedo carcinoma 10.0 PGR ESR1
49 breast metaplastic carcinoma 10.0 PGR ESR1
50 mammographic density 10.0 PGR ESR1

Graphical network of the top 20 diseases related to Vagina Leiomyosarcoma:



Diseases related to Vagina Leiomyosarcoma

Symptoms & Phenotypes for Vagina Leiomyosarcoma

MGI Mouse Phenotypes related to Vagina Leiomyosarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.35 ESR1 KIT MLANA MYOG PGR
2 no phenotypic analysis MP:0003012 9.02 ESR1 KIT MLANA MYOG PGR

Drugs & Therapeutics for Vagina Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Vagina Leiomyosarcoma

Genetic Tests for Vagina Leiomyosarcoma

Anatomical Context for Vagina Leiomyosarcoma

MalaCards organs/tissues related to Vagina Leiomyosarcoma:

40
Breast, Smooth Muscle, Lung, Uterus, Prostate, Kidney, Heart

Publications for Vagina Leiomyosarcoma

Articles related to Vagina Leiomyosarcoma:

(show all 26)
# Title Authors PMID Year
1
Successful robotic surgery for primary resection of a vaginal leiomyosarcoma: A case report. 61
31656851 2019
2
Unusual indolent behavior of leiomyosarcoma of the vagina: Is observation a viable option? 61
28649595 2017
3
Urethral Stenting for Obstructive Uropathy Utilizing Digital Radiography for Guidance: Feasibility and Clinical Outcome in 26 Dogs. 61
28132405 2017
4
A large primary retroperitoneal vaginal leiomyosarcoma: a case report. 61
26040930 2015
5
Leiomyosarcoma of the Vagina: An Exceedingly Rare Diagnosis. 61
26783476 2015
6
[Leiomyosarcoma of the vagina: a case report and review from the literature]. 61
25909129 2015
7
Leiomyosarcoma of the vagina in pregnancy. 61
26189266 2015
8
A large primary vaginal leiomyosarcoma diagnosed postoperatively and uterine leiomyomas treated with surgery and chemotherapy. 61
23919878 2013
9
[Primary leiomyosarcoma of the vagina: a clinical analysis of 9 cases]. 61
23302732 2012
10
Stage IV Primary Vaginal Leiomyosarcoma with Lung and Breast Metastases. 61
22740804 2012
11
An unusual case of vaginal leiomyosarcoma in pregnancy. 61
20925626 2010
12
Leiomyosarcoma of the vagina: MR findings. 61
19857812 2009
13
Leiomyosarcoma of the vagina: a case report and review from the literature. 61
19471654 2008
14
Vaginal leiomyosarcoma. 61
18850448 2008
15
Thoracotomy for the management of recurrent vaginal leiomyosarcoma. 61
17506839 2008
16
Combined laparoscopic and radical vaginal treatment of primary vaginal leiomyosarcoma in a patient with unicornuate uterus and pelvic kidney. 61
17630176 2007
17
Primary leiomyosarcoma of the vagina: a case report involving a TVT allograft. 61
15350385 2004
18
Primary vaginal leiomyosarcoma in pregnancy. 61
14675689 2003
19
[Vaginal leiomyosarcoma. Apropos of 2 cases and review of the literature]. 61
12199042 2002
20
Primary leiomyosarcoma of the vagina. A case report and literature review. 61
11240697 2000
21
[Leiomyosarcoma of the vagina: a rare case]. 61
9180848 1997
22
[A rare vaginal tumor: primary leiomyosarcoma. A case report]. 61
7644871 1995
23
Primary leiomyosarcoma of the vagina. 61
4018368 1985
24
Primary leiomyosarcoma of the vagina: a study of five cases. 61
6714808 1984
25
[Cytology and histology of vaginal leiomyosarcoma: a rare tumor (author's transl)]. 61
992318 1976
26
[On a case of primary malignant tumor of the vagina (leiomyosarcoma)]. 61
13873292 1960

Variations for Vagina Leiomyosarcoma

Expression for Vagina Leiomyosarcoma

Search GEO for disease gene expression data for Vagina Leiomyosarcoma.

Pathways for Vagina Leiomyosarcoma

GO Terms for Vagina Leiomyosarcoma

Biological processes related to Vagina Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.62 PGR MYOG ESR1 ADIRF
2 steroid hormone mediated signaling pathway GO:0043401 9.26 PGR ESR1
3 cellular response to estradiol stimulus GO:0071392 9.16 MYOG ESR1
4 stem cell differentiation GO:0048863 8.96 KIT ESR1
5 positive regulation of phospholipase C activity GO:0010863 8.62 KIT ESR1

Molecular functions related to Vagina Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hormone receptor activity GO:0003707 9.16 PGR ESR1
2 nuclear receptor activity GO:0004879 8.96 PGR ESR1
3 steroid binding GO:0005496 8.62 PGR ESR1

Sources for Vagina Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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