MCID: VGN014
MIFTS: 30

Vagina Sarcoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Vagina Sarcoma

MalaCards integrated aliases for Vagina Sarcoma:

Name: Vagina Sarcoma 12 15
Sarcoma of the Vagina 12
Vaginal Sarcoma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:1901
NCIt 50 C7737
UMLS 70 C0238519

Summaries for Vagina Sarcoma

Disease Ontology : 12 A vaginal cancer that has material basis in connective tissue.

MalaCards based summary : Vagina Sarcoma, also known as sarcoma of the vagina, is related to vagina leiomyosarcoma and ewing sarcoma. An important gene associated with Vagina Sarcoma is JAZF1 (JAZF Zinc Finger 1), and among its related pathways/superpathways are NF-kappaB Signaling and Tyrosine Kinases / Adaptors. Affiliated tissues include breast, lung and skin, and related phenotypes are cellular and integument

Related Diseases for Vagina Sarcoma

Diseases related to Vagina Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 274)
# Related Disease Score Top Affiliating Genes
1 vagina leiomyosarcoma 31.4 MYOG MLANA
2 ewing sarcoma 29.6 VIM MYOG KIT IGF1R
3 sarcoma, synovial 29.3 VIM MYOG KIT IGF1R CD34
4 angiosarcoma 29.3 VIM MLANA KIT CD34
5 rhabdomyosarcoma 29.2 VIM MYOG MME KIT IGF1R
6 endometrial stromal tumor 29.1 YWHAE SUZ12 PHF1 PGR MME JAZF1
7 vaginal endometrial stromal sarcoma 29.1 YWHAE VIM SUZ12 STAT6 PHF1 PGR
8 spindle cell sarcoma 29.1 VIM MYOG KIT CD34 CALD1
9 leiomyosarcoma 28.7 VIM PGR MYOG MLANA KIT
10 endometrial stromal sarcoma 28.5 YWHAE VIM SUZ12 PHF1 PGR MME
11 alveolar soft part sarcoma 10.4
12 vaginal endometrial stromal tumor 10.3 MME CALD1
13 mixed endometrial stromal and smooth muscle tumor 10.3 MME CALD1
14 fallopian tube leiomyoma 10.3 MME CALD1
15 fallopian tube benign neoplasm 10.3 MME CALD1
16 subareolar duct papillomatosis 10.3 MME CALD1
17 cervical mucinous adenocarcinoma 10.3 MME CALD1
18 nipple benign neoplasm 10.3 MME CALD1
19 atypical polypoid adenomyoma 10.3 MME CALD1
20 rare tumor 10.3
21 myofibroma 10.3 CD34 CALD1
22 intravascular angioleiomyoma 10.3 CD34 CALD1
23 testicular fibroma 10.2 CD34 CALD1
24 congenital granular cell tumor 10.2 CD34 CALD1
25 subungual glomus tumor 10.2 CD34 CALD1
26 pediatric liposarcoma 10.2 VIM CD34
27 benign pleural mesothelioma 10.2 STAT6 CD34
28 diffuse peritoneal leiomyomatosis 10.2 PGR CALD1
29 lung leiomyoma 10.2 PGR CALD1
30 gastric leiomyoma 10.2 KIT CALD1
31 extraosseous osteosarcoma 10.2 CD34 CALD1
32 ossifying fibromyxoid tumor 10.2 VIM PHF1
33 soft tissue sarcoma 10.2
34 odontogenic myxoma 10.2 VIM IGF1R
35 meninges hemangiopericytoma 10.2 STAT6 CD34
36 pacinian tumor 10.2 MME CD34
37 testicular gonadoblastoma 10.2 VIM KIT
38 atypical neurofibroma 10.2 SUZ12 CD34
39 lymphangiomatosis 10.2 VIM PGR
40 inflammatory liposarcoma 10.2 MME CD34
41 congenital epulis 10.2 VIM PGR
42 epulis 10.2 VIM PGR
43 bizarre leiomyoma 10.2 PGR CALD1
44 endometrial mucinous adenocarcinoma 10.2 VIM PGR
45 cervical adenomyoma 10.2 PGR MME
46 cervical benign neoplasm 10.2 PGR MME
47 benign metastasizing leiomyoma 10.2 VIM PGR
48 uterine corpus adenosarcoma 10.2 PGR MME
49 fallopian tube endometriosis 10.2 PGR MME
50 senile angioma 10.2 VIM KIT

Graphical network of the top 20 diseases related to Vagina Sarcoma:



Diseases related to Vagina Sarcoma

Symptoms & Phenotypes for Vagina Sarcoma

MGI Mouse Phenotypes related to Vagina Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.85 CD34 IGF1R KIT MME MYOG PGR
2 integument MP:0010771 9.61 CD34 IGF1R KIT MLANA MME MYOG
3 neoplasm MP:0002006 9.1 CD34 IGF1R KIT PGR STAT6 SUZ12

Drugs & Therapeutics for Vagina Sarcoma

Search Clinical Trials , NIH Clinical Center for Vagina Sarcoma

Genetic Tests for Vagina Sarcoma

Anatomical Context for Vagina Sarcoma

MalaCards organs/tissues related to Vagina Sarcoma:

40
Breast, Lung, Skin, Myeloid, Heart, Small Intestine, Liver

Publications for Vagina Sarcoma

Articles related to Vagina Sarcoma:

(show all 36)
# Title Authors PMID Year
1
Primary vaginal sarcoma treated with upfront fertility-sparing surgery. 61
33649019 2021
2
Targeted Treatment of a Rare Vaginal Sarcoma With an Anaplastic Lymphoma Kinase Inhibitor. 61
31348218 2019
3
When an Unexpected Diagnosis Occurs: a Vaginal Premenopausal Sarcoma. 61
29341035 2018
4
Targeted Treatment of a Rare Vaginal Sarcoma With an Anaplastic Lymphoma Kinase Inhibitor. 61
26942346 2016
5
Primary vaginal sarcoma: Experience of a regional cancer center in China. 61
26111799 2015
6
Comparing mortality of vaginal sarcoma, squamous cell carcinoma, and adenocarcinoma in the surveillance, epidemiology, and end results database. 61
26000506 2015
7
Stage IV Primary Vaginal Leiomyosarcoma with Lung and Breast Metastases. 61
22740804 2012
8
Imaging of female pelvic malignancies regarding MRI, CT, and PET/CT: Part 2. 61
22037656 2011
9
Pregnancy and genital sarcoma: a systematic review of the literature. 61
19288396 2009
10
Cytology of vaginal and uterine sarcomas. 61
15471250 2004
11
Primary leiomyosarcoma of the vagina: a case report involving a TVT allograft. 61
15350385 2004
12
Primary vaginal leiomyosarcoma in pregnancy. 61
14675689 2003
13
Bleeding from endometrial and vaginal malignant tumors treated with activated recombinant factor VII. 61
12214734 2002
14
[Clinical report of six cases of vaginal sarcomas]. 61
11263187 1999
15
Vaginal sarcoma: the Royal Marsden experience. 61
11578429 1994
16
Pelvic exenteration, University of Michigan: 100 patients at 5 years. 61
2586960 1989
17
[Primary carcinomas and sarcomas of the vagina - therapeutic results (author's transl)]. 61
7456892 1980
18
Incidence of malignancy in Jewish women with postmenopausal bleeding. 61
856767 1977
19
Long survival after vaginal sarcoma botryoides. 61
1009328 1976
20
Sarcomas of the vagina. 61
1250563 1976
21
[Vaginal sarcoma in childhood]. 61
4411468 1974
22
Vaginal sarcoma botryoides. 61
5930340 1966
23
[VAGINAL SARCOMA WITH VERY LONG EVOLUTION]. 61
14290892 1964
24
BOTRYOID VAGINAL SARCOMA, A CASE REPORT. 61
14057071 1962
25
[Diagnosis and therapy of vaginal sarcoma in childhood]. 61
13779597 1961
26
[Vaginal sarcoma in childhood]. 61
13497157 1957
27
[Vaginal sarcoma in children]. 61
14382275 1955
28
[Primary vaginal sarcoma in ninth month of pregnancy]. 61
13123384 1953
29
[Vaginal sarcoma and pre-invasive cervical carcinoma]. 61
14867353 1951
30
[Two cases of vaginal sarcoma in young children]. 61
14841759 1951
31
[2 Cases of vaginal sarcoma in young children]. 61
14858993 1951
32
[Primary vaginal sarcoma and Recklinghausen's disease in the latter half of pregnancy]. 61
14828991 1950
33
[Case of vaginal sarcoma in an adult 11 months of age]. 61
18229155 1949
34
[Vaginal sarcoma]. 61
15401319 1949
35
Three cases of childhood vaginal sarcoma. 61
18886089 1948
36
Mass projecting from vagina. [Sarcoma botryoides]. 61
21027156 1946

Variations for Vagina Sarcoma

Expression for Vagina Sarcoma

Search GEO for disease gene expression data for Vagina Sarcoma.

Pathways for Vagina Sarcoma

GO Terms for Vagina Sarcoma

Cellular components related to Vagina Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ESC/E(Z) complex GO:0035098 8.62 SUZ12 PHF1

Biological processes related to Vagina Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amyloid-beta clearance GO:0097242 8.96 MME IGF1R
2 paracrine signaling GO:0038001 8.62 PGR CD34

Molecular functions related to Vagina Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II transcription corepressor binding GO:0001226 8.62 SUZ12 PHF1

Sources for Vagina Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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