MCID: VGN018
MIFTS: 22

Vaginal Carcinosarcoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Vaginal Carcinosarcoma

MalaCards integrated aliases for Vaginal Carcinosarcoma:

Name: Vaginal Carcinosarcoma 12 15 17 71
Malignant Vaginal Mixed Epithelial and Mesenchymal Tumor 12
Vaginal Mixed Epithelial and Mesenchymal Tumor 12
Vaginal Malignant Mixed Mesodermal Tumor 12
Vaginal Malignant Mixed Mullerian Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:136
UMLS 71 C1512974 C1519918 C1519924

Summaries for Vaginal Carcinosarcoma

Disease Ontology : 12 A vaginal carcinoma that has material basis in connective tissue.

MalaCards based summary : Vaginal Carcinosarcoma, also known as malignant vaginal mixed epithelial and mesenchymal tumor, is related to vaginal adenosarcoma and benign vaginal carcinosarcoma. An important gene associated with Vaginal Carcinosarcoma is ERBB4 (Erb-B2 Receptor Tyrosine Kinase 4), and among its related pathways/superpathways are mTOR signaling pathway (KEGG) and Apoptosis Pathway. Affiliated tissues include kidney and b cells, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Vaginal Carcinosarcoma

Graphical network of the top 20 diseases related to Vaginal Carcinosarcoma:



Diseases related to Vaginal Carcinosarcoma

Symptoms & Phenotypes for Vaginal Carcinosarcoma

GenomeRNAi Phenotypes related to Vaginal Carcinosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.61 MTOR
2 Decreased viability GR00221-A-1 9.61 MTOR
3 Decreased viability GR00221-A-4 9.61 MTOR
4 Decreased viability GR00301-A 9.61 ERBB4
5 Decreased viability GR00342-S-1 9.61 ERBB4 MTOR
6 Decreased viability GR00342-S-2 9.61 MTOR
7 Decreased viability GR00402-S-2 9.61 ERBB4 MTOR
8 Increased cell migration GR00055-A-3 8.62 ERBB4 MTOR

Drugs & Therapeutics for Vaginal Carcinosarcoma

Search Clinical Trials , NIH Clinical Center for Vaginal Carcinosarcoma

Genetic Tests for Vaginal Carcinosarcoma

Anatomical Context for Vaginal Carcinosarcoma

MalaCards organs/tissues related to Vaginal Carcinosarcoma:

40
Kidney, B Cells

Publications for Vaginal Carcinosarcoma

Articles related to Vaginal Carcinosarcoma:

# Title Authors PMID Year
1
Primary carcinosarcoma of the vagina. 61
12588439 2003
2
[Vaginal carcinosarcoma (report of a case)]. 61
4832728 1974

Variations for Vaginal Carcinosarcoma

Expression for Vaginal Carcinosarcoma

Search GEO for disease gene expression data for Vaginal Carcinosarcoma.

Pathways for Vaginal Carcinosarcoma

Pathways related to Vaginal Carcinosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.72 MTOR ERBB4
2
Show member pathways
11.58 MTOR ERBB4
3
Show member pathways
11.51 MTOR ERBB4
4
Show member pathways
11.45 MTOR ERBB4
5 10.93 MTOR ERBB4

GO Terms for Vaginal Carcinosarcoma

Biological processes related to Vaginal Carcinosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.26 MTOR ERBB4
2 positive regulation of protein kinase B signaling GO:0051897 9.16 MTOR ERBB4
3 protein autophosphorylation GO:0046777 8.96 MTOR ERBB4
4 positive regulation of neurogenesis GO:0050769 8.62 MTOR MME

Sources for Vaginal Carcinosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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