MCID: VGN019
MIFTS: 47

Vaginal Discharge

Categories: Reproductive diseases

Aliases & Classifications for Vaginal Discharge

MalaCards integrated aliases for Vaginal Discharge:

Name: Vaginal Discharge 12 44 15 17

Classifications:



External Ids:

Disease Ontology 12 DOID:3767
MeSH 44 D019522
NCIt 50 C50795
SNOMED-CT 67 70856007
UMLS 70 C0227791

Summaries for Vaginal Discharge

Disease Ontology : 12 A vaginal disease that is characterized by the presence of discharge.

MalaCards based summary : Vaginal Discharge is related to bacterial vaginosis and chlamydia. An important gene associated with Vaginal Discharge is CRP (C-Reactive Protein), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Estrogens, Conjugated (USP) and Fluconazole have been mentioned in the context of this disorder. Affiliated tissues include cervix, uterus and colon, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and cardiovascular system

Wikipedia : 73 Vaginal discharge is a mixture of liquid, cells, and bacteria that lubricate and protect the vagina.... more...

Related Diseases for Vaginal Discharge

Diseases related to Vaginal Discharge via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 909)
# Related Disease Score Top Affiliating Genes
1 bacterial vaginosis 31.0 TNF LAP3 IL6 IL1B IL1A IL10
2 chlamydia 30.9 TNF IL6 IL1B IL1A IL10 CXCL8
3 trichomoniasis 30.8 TNF SLPI LAP3 IL6 IL1B IL10
4 candidiasis 30.6 TNF IL6 IL1B IL10 CXCL8
5 postmenopausal atrophic vaginitis 30.4 GNRH1 ESR1
6 vaginitis 30.3 TNF SLPI LAP3 IL6 IL1B IL1A
7 syphilis 30.1 TNF IL6 CRP CD4 ALB
8 cervicitis 30.1 TNF IL6 IL1B IL10 CXCL8 CD4
9 haemophilus influenzae 30.0 TNF CXCL8
10 endometritis 30.0 TNF PGR OXT IL6 IL1B HP
11 anovulation 30.0 HP GNRH1 CYP19A1 CRP
12 varicose veins 29.9 TNF IL6 CXCL8
13 ectopic pregnancy 29.9 PGR IL1B GNRH1
14 sexual disorder 29.9 OXT GNRH1 ALB
15 leiomyoma 29.8 PGR GNRH1 ESR1 CYP19A1
16 cystitis 29.6 TNF IL6 IL1A CXCL8 CRP
17 urethritis 29.5 TNF IL6 IL1B IL10 CXCL8 CRP
18 myositis 29.5 TNF IL6 IL1B IL1A CXCL8
19 gestational diabetes 29.4 TNF PTPRN IL6 CRP
20 thrombocytosis 29.4 IL6 IL1B IL1A CRP ALB
21 colitis 29.3 TNF IL6 IL1B IL10 CXCL8 CD4
22 adenomyosis 29.3 PGR OXT IL6 GNRH1 ESR1 CYP19A1
23 ulcerative colitis 29.3 TNF IL6 IL1B IL10 CXCL8 CRP
24 endometriosis 29.2 PGR IL6 IL1B GNRH1 ESR1 CYP19A1
25 deficiency anemia 29.2 TNF OXT IL6 HP CRP CD4
26 schistosomiasis 29.1 TNF IL1A IL10 ALB
27 appendicitis 28.9 TNF IL6 IL1B IL10 CXCL8 CRP
28 dermatitis 28.9 TNF IL6 IL1B IL1A IL10 CXCL8
29 acute cystitis 28.7 TNF IL6 IL1B IL10 CXCL8 CRP
30 bacterial infectious disease 28.7 TNF IL6 IL1B IL1A IL10 CXCL8
31 immune deficiency disease 28.7 TNF SLPI IL6 IL1B IL1A IL10
32 respiratory failure 28.3 TNF IL6 IL1B IL1A IL10 CXCL8
33 connective tissue disease 28.3 TNF IL6 IL1B IL1A IL10 CXCL8
34 skin disease 28.3 TNF IL6 IL1B IL1A IL10 CXCL8
35 pelvic inflammatory disease 11.2
36 leukorrhea 11.2
37 vulvovaginal candidiasis 11.1
38 trichomonas vaginalis trichomoniasis 11.1
39 fallopian tube carcinoma 11.1
40 uterine carcinosarcoma 11.1
41 fitz-hugh-curtis syndrome 11.1
42 acquired angioedema 10.4 HP CRP
43 panophthalmitis 10.4 CRP CD4
44 cold agglutinin disease 10.4 IL6 CRP
45 wells syndrome 10.4 IL1B CXCL8 CRP
46 breast abscess 10.4 OXT CRP CD4
47 vulvovaginitis 10.4
48 urogenital tuberculosis 10.4 SLPI CRP CD4
49 drug reaction with eosinophilia and systemic symptoms 10.4 TNF CRP
50 cervical adenitis 10.3 IL1B CRP CD4

Graphical network of the top 20 diseases related to Vaginal Discharge:



Diseases related to Vaginal Discharge

Symptoms & Phenotypes for Vaginal Discharge

GenomeRNAi Phenotypes related to Vaginal Discharge according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 8.92 CXCL8 ESR1 PTPRN TNF

MGI Mouse Phenotypes related to Vaginal Discharge:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.23 ALB CRP CYP19A1 ESR1 HP IL10
2 homeostasis/metabolism MP:0005376 10.22 ALB CD4 CRP CYP19A1 ESR1 GNRH1
3 immune system MP:0005387 10.16 ALB CD4 CRP CYP19A1 ESR1 GNRH1
4 hematopoietic system MP:0005397 10.15 CD4 CYP19A1 ESR1 GNRH1 HP IL10
5 endocrine/exocrine gland MP:0005379 10.14 ALB CD4 CYP19A1 ESR1 GNRH1 IL10
6 digestive/alimentary MP:0005381 10.09 ALB CD4 CYP19A1 ESR1 GNRH1 IL10
7 integument MP:0010771 9.9 CD4 CYP19A1 ESR1 GNRH1 IL10 IL1A
8 liver/biliary system MP:0005370 9.56 ALB CYP19A1 ESR1 GNRH1 HP IL10
9 neoplasm MP:0002006 9.32 ALB ESR1 GNRH1 HP IL10 IL1A

Drugs & Therapeutics for Vaginal Discharge

Drugs for Vaginal Discharge (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Estrogens, Conjugated (USP) Phase 4
2
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
3
Tinidazole Approved, Investigational Phase 3 19387-91-8 5479
4
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
5
Secnidazole Approved Phase 3 3366-95-8
6
Povidone Approved Phase 3 9003-39-8 131751496
7
Povidone-iodine Approved Phase 3 25655-41-8
8
Ethanol Approved Phase 3 64-17-5 702
9
Chlorhexidine Approved, Vet_approved Phase 3 55-56-1 2713 9552079
10
Iodine Approved, Investigational Phase 3 7553-56-2 807
11
Cadexomer iodine Experimental Phase 3 94820-09-4
12 Alkylating Agents Phase 3
13 Clindamycin phosphate Phase 3
14 Clindamycin palmitate Phase 3
15 Analgesics Phase 3
16 Pharmaceutical Solutions Phase 3
17 Chlorhexidine gluconate Phase 3
18 Dermatologic Agents Phase 3
19 Plasma Substitutes Phase 3
20 Blood Substitutes Phase 3
21 Disinfectants Phase 3

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Postmenopausal Pessary Users: Estrogen Versus Trimosan Recruiting NCT03943823 Phase 4 Estrogen vaginal cream;Trimo-San vaginal gel
2 A Randomised Controlled Trial of Single Dose Tinidazole+Fluconazole Versus Longer Courses of Metronidazole+Clotrimazole in the Management of West African Women With Vaginal Discharge Completed NCT00313131 Phase 3 tinidazole+fluconazole vs metronidazole+clotrimazole
3 A Multi-center, Double-blind, Randomized Study, Comparing Clindamycin Phosphate Vaginal Cream 2% (Watson Laboratories, Inc.) to Clindesse® (Ther-Rx™, Clindamyin Phosphate Vaginal Cream 2%) and Both Active Treatments to a Placebo Control in the Treatment of Bacterial Vaginosis in Non-pregnant Women Completed NCT02210689 Phase 3 clindamycin phosphate vaginal cream 2%
4 Safety and Clinical and Microbiological Efficacy of the Combination of Fluconazole and Secnidazole for the Treatment of Symptomatic Vaginal Discharge. Bogotá D. C. Colombia. Completed NCT02111629 Phase 3 Fluconazole and Secnidazole
5 Rapid Palliation in Locally Advanced Cervical Cancer: A Phase III Randomized Trial Recruiting NCT03997110 Phase 3
6 Povidone-iodine vs. Chlorhexidine Gluconate - A Comparison of Surgical Preparations and Wound Infection Rates for Elective Cesarean Sections Terminated NCT00528008 Phase 3
7 Phase III, Multicenter, Randomized, Parallel, Open Label, Controlled and Comparative Study to Evaluate the Efficacy and Safety of the Association of Clotrimazole 200mg and Metronidazole 0,75% (Colpistatin 5DT®) Compared to Gynecological Flagyl®(Metronidazole 100mg/g) and the Vaginal Cream Gino-Canesten® 3 (Clotrimazole 20mg/g) in the Syndromic Treatment of the Vaginal Discharge From Different Etiologies. Withdrawn NCT02713139 Phase 3 Clotrimazole + Metronidazole;Metronidazole;Clotrimazole
8 A Multicenter, Randomized, Investigator-Blinded, Phase 2, Dose Ranging Study of Metronidazole Vaginal Gel in the Treatment of Bacterial Vaginosis Completed NCT01055106 Phase 2 GW05;GW05;GW05;Metronidazole
9 Vaginal Creams for Reduction of Vaginal Discharge and Erosion in Patients Using Ring With Support or Gellhorn Pessaries to Reduce Pelvic Organ Prolapse Withdrawn NCT02316249 Phase 2 Estradiol
10 Conservative Management of Symptomatic Pelvic Organ Prolapse Using Vaginal Pessaries: Generation of a Standardized Management Protocol Unknown status NCT02113969
11 Validity of Patient-Collected Wet Mounts Completed NCT02641717
12 Prospective Evaluation of the Impact of Bacterial Vaginosis and Its Treatment on Mucosal Susceptibility to HIV-1 Infection and Endpoints of Cervico-Vaginal Safety Completed NCT01347632 Metronidazole
13 A Validation Study of Genzyme Diagnostics OSOM Trichomonas Rapid Test and BVBlue Test Completed NCT00682851
14 Epidemiology and Clinico-investigative Study of Abnormal Vaginal Discharge During Pregnancy Recruiting NCT04719754
15 Evaluate the Agreement of High-risk Human Papillomavirus (hrHPV) Type Between Self-collected Vaginal Discharge Sample Using "Hygeia Touch Self Sampling Kit for Women" and Physician Collected Sample From the Cervical Surface Recruiting NCT04472377
16 EMMI - Emättimen Mikrobiomi - Emättimen ja Suun Limakalvojen Vuorovaikutus Recruiting NCT02898818
17 Gyni™ System Pilot Study With Leumit Health Services - Prospective Study Recruiting NCT04816903
18 Clinical Study of STI Screening to Prevent Adverse Birth and New-born Outcomes Not yet recruiting NCT04446611

Search NIH Clinical Center for Vaginal Discharge

Cochrane evidence based reviews: vaginal discharge

Genetic Tests for Vaginal Discharge

Anatomical Context for Vaginal Discharge

MalaCards organs/tissues related to Vaginal Discharge:

40
Cervix, Uterus, Colon, Ovary, Breast, Skin, Lymph Node

Publications for Vaginal Discharge

Articles related to Vaginal Discharge:

(show top 50) (show all 3171)
# Title Authors PMID Year
1
Options for Teens with No Options: A Self-Managed Second Trimester Abortion. 61
33242593 2021
2
Accuracy of Vaginal pH Testing Before and After Addition of Sterile Saline. 61
33660675 2021
3
Vaginal Rejuvenation: A Retrospective Review of Lasers and Radiofrequency Devices. 61
33165070 2021
4
A phase 3, randomized, controlled trial of Astodrimer 1% Gel for preventing recurrent bacterial vaginosis. 61
33537666 2021
5
Gynaecological morbidities among married women and husband's behaviour: Evidence from a community-based study. 61
33570305 2021
6
Association of Self-Reported Physical Fitness with Pregnancy Related Symptoms the GESTAFIT Project. 61
33804923 2021
7
The economic cost of metritis in dairy herds. 61
33455790 2021
8
Relationship Between Ano-vaginal Distance and Bacterial Vaginosis (Cross-sectional Study). 61
33675029 2021
9
The vaginal microbiota in the course of bacterial vaginosis treatment. 61
33029765 2021
10
Twice-Daily Nitrofurantoin Administration Following Short-term Transurethral Catheterization After Pelvic Reconstructive Surgery: A Randomized Clinical Trial. 61
33620905 2021
11
EVO100 Prevents Chlamydia and Gonorrhea in Women At High-Risk For Infection. 61
33705748 2021
12
Short communication: Efficacy of a second intrauterine cephapirin infusion for the treatment of purulent vaginal discharge and endometritis in postpartum dairy cows. 61
33358808 2021
13
Uptake and safety of community-based "screen-and-treat" with thermal ablation preventive therapy for cervical cancer prevention in rural Lilongwe, Malawi. 61
33687746 2021
14
Early detection of cervical cancer in western Kenya: determinants of healthcare providers performing a gynaecological examination for abnormal vaginal discharge or bleeding. 61
33706721 2021
15
Failure of clinical cure in dairy cows treated for metritis is associated with reduced productive and reproductive performance. 61
33741169 2021
16
Controlled trial of the effect of negative dietary cation-anion difference on postpartum health of dairy cows. 61
33714580 2021
17
Unusual migration of distal ventriculoperitoneal shunt to Vagina via fallopian tube: A case report. 61
33659058 2021
18
Vaginal foreign body insertion in a patient with emotionally unstable personality disorder. 61
33653848 2021
19
[Birth of a vital puppy following prolonged whelping in a Labrador Retriever]. 61
33588465 2021
20
Turkish translation, cross-cultural adaptation, and psychometric validation of the pregnancy symptoms inventory: An instrument to assess the full spectrum of pregnancy symptoms. 61
33640592 2021
21
Evaluation of different acute-phase proteins for herd health diagnostics in early postpartum Holstein Friesian dairy cows. 61
33594968 2021
22
Colouterine fistula: A case report of a rare complication of diverticular disease managed during the pandemic. 61
33477073 2021
23
Declines in HIV prevalence in female sex workers accessing an HIV treatment and prevention programme in Nairobi, Kenya over a 10-year period. 61
33165030 2021
24
How often should ring pessaries be removed or changed in women with advanced POP? A prospective observational study. 61
33620536 2021
25
Effects of metritis treatment strategies on health, behavior, reproductive, and productive responses of Holstein cows. 61
33309374 2021
26
High Prevalence of Sexually Transmitted Infections in Pregnant Women Living in Southern Brazil. 61
32976355 2021
27
The use of vaginal wet smear: can we predict Mycoplasmas/Ureaplasmas? 61
33544205 2021
28
Female pelvic congestion syndrome: how can CT and MRI help in the management decision? 61
33252986 2021
29
Guideline No. 411: Vaginal Pessary Use. 61
33248302 2021
30
Thermocoagulation versus cryotherapy for the treatment of cervical precancers. 61
33089619 2021
31
Group B Streptococcus colonisation and their antimicrobial susceptibility among pregnant women attending antenatal clinics in tertiary care hospitals in the Western Province of Sri Lanka. 61
32172646 2021
32
Genomic characteristics of Streptococcus agalactiae based on the pan-genome orthologous group analysis according to invasiveness and capsular genotype. 61
33526285 2021
33
Effects of prepartum stocking density and a blind on physiological biomarkers, health, and hygiene of transition Holstein dairy cows. 61
33162092 2021
34
Continuous versus interrupted use of vaginal probiotics plus vaginal clindamycin cream for bacterial vaginosis: a randomized controlled study. 61
30879366 2021
35
A novel non-antimicrobial treatment of bacterial vaginosis: An open label two-private centre study. 61
33307324 2021
36
Immature teratoma arising from uterine corpus in an 11-year-old girl: Case report and review of the literature. 61
33197962 2021
37
[Brazilian Protocol for Sexually Transmitted Infections 2020: infections causing vaginal discharge]. 61
33729401 2021
38
Comparison of the effectiveness of Satureja khuzestanica and clotrimazole vaginal creams for the treatment of vulvovaginal candidiasis. 61
33767795 2021
39
Are Mycoplasma hominis, Ureaplasma urealyticum and Ureaplasma parvum associated with specific genital symptoms and clinical signs in non-pregnant women? 61
33502501 2021
40
Risk Factors for Dislodgment of Vaginal Pessaries in Women With Pelvic Organ Prolapse: A Cohort Study. 61
32487886 2021
41
ESTROgen use for complications in women treating pelvic organ prolapse with vaginal PESSaries (ESTRO-PESS)-a randomized clinical trial. 61
33501563 2021
42
INTENSIVE TREATMENT OF A CAPTIVE BORNEAN ELEPHANT (ELEPHAS MAXIMUS BORNEENSIS) INFECTED WITH MYCOBACTERIUM CAPRAE IN JAPAN. 61
33480591 2021
43
Role of various screening techniques in detecting preinvasive lesions of the cervix among symptomatic women and women having unhealthy cervix. 61
33723152 2021
44
Characterization of intrauterine cultivable aerobic microbiota at the time of insemination in dairy cows with and without mild endometritis. 61
33113441 2021
45
Prevalence, Etiology, and Associated Symptoms of Vaginal Discharge During Pregnancy in Women Seen in a Tertiary Care Hospital in Bihar. 61
33614308 2021
46
Serratia marcescens as a cause of unfavorable outcome in the twin pregnancy. 61
33385065 2021
47
Prevalence, risk factors and association with delivery outcome of curable sexually transmitted infections among pregnant women in Southern Ethiopia. 61
33760867 2021
48
Vaginal Dysbiosis and Partial Bacterial Vaginosis: The Interpretation of the "Grey Zones" of Clinical Practice. 61
33525708 2021
49
Prevalence of shedding and antibody to Coxiella burnetii in post-partum dairy cows and its association with reproductive tract diseases and performance: A pilot study. 61
33360180 2021
50
Neisseria Gonorrhoeae Spontaneous Bacterial Peritonitis. 61
33777466 2021

Variations for Vaginal Discharge

Expression for Vaginal Discharge

Search GEO for disease gene expression data for Vaginal Discharge.

Pathways for Vaginal Discharge

Pathways related to Vaginal Discharge according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 TNF IL6 IL1B IL1A IL10 GNRH1
2
Show member pathways
13.56 TNF IL6 IL1B IL1A IL10 GNRH1
3
Show member pathways
13.43 TNF IL6 IL1B IL1A IL10 GNRH1
4
Show member pathways
13.38 TNF SHC2 IL6 IL1B IL1A IL10
5
Show member pathways
13.33 TNF PTPRN IL6 IL1B IL1A IL10
6
Show member pathways
12.85 TNF PTPRN IL6 IL1B IL1A IL10
7
Show member pathways
12.74 TNF IL6 IL1B IL1A CXCL8
8
Show member pathways
12.72 TNF IL6 IL1B IL1A GNRH1
9
Show member pathways
12.66 TNF IL6 IL1B IL1A IL10 CD4
10
Show member pathways
12.65 TNF IL6 IL1B IL1A IL10 CD4
11
Show member pathways
12.61 TNF IL6 IL1B IL10 CD4
12
Show member pathways
12.38 TNF IL6 IL1B CRP ALB
13
Show member pathways
12.36 TNF IL6 IL1B IL1A CXCL8
14
Show member pathways
12.35 TNF IL6 IL1B CXCL8
15
Show member pathways
12.35 TNF IL6 IL10 CXCL8
16 12.3 TNF IL6 IL1B IL1A IL10
17
Show member pathways
12.3 TNF IL6 IL1B IL1A IL10 GNRH1
18
Show member pathways
12.28 TNF IL6 IL1A CXCL8
19
Show member pathways
12.28 TNF IL1B IL1A IL10
20 12.25 TNF IL6 IL1B CXCL8
21
Show member pathways
12.23 TNF IL6 IL1B IL10
22
Show member pathways
12.21 TNF IL6 IL1B CXCL8
23 12.18 TNF IL6 IL1B IL1A IL10 CXCL8
24 12.08 TNF IL6 IL1B IL1A CXCL8
25 12.06 TNF IL6 IL10 CEACAM5 CD4
26 12.05 TNF IL6 IL1B IL10 CXCL8 CD4
27 11.99 TNF IL6 IL1B IL10 CXCL8
28 11.98 IL6 IL1B IL1A CXCL8
29 11.97 TNF IL6 IL1B IL1A CXCL8
30 11.96 TNF IL6 IL1B IL1A CD4
31 11.92 TNF IL6 IL1B IL1A CXCL8
32 11.9 TNF IL6 IL1B IL1A IL10 CXCL8
33 11.85 TNF IL1B IL10 CD4
34
Show member pathways
11.82 TNF IL6 IL1B IL10 CD4
35 11.79 TNF IL6 IL1B IL10 CD4
36 11.73 TNF IL6 IL1B CXCL8
37 11.71 TNF IL6 IL10
38 11.67 TNF IL6 IL1B CXCL8
39
Show member pathways
11.65 TNF IL6 IL1B IL1A CXCL8
40 11.54 IL6 IL1B IL1A
41 11.54 TNF IL6 HP
42 11.51 TNF IL6 IL1B IL1A IL10 CXCL8
43 11.5 TNF IL6 IL1B IL10 CXCL8
44 11.46 TNF IL6 IL1B IL10
45 11.37 TNF IL6 IL1B IL1A CYP19A1
46 11.35 TNF IL6 IL1B
47 11.33 TNF IL6 IL1B
48 11.2 TNF IL6 IL1B IL1A IL10
49 11.17 TNF PGR IL1B
50 11.12 TNF IL6 IL1B IL1A IL10 CXCL8

GO Terms for Vaginal Discharge

Cellular components related to Vaginal Discharge according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 TNF SLPI OXT IL6 IL1B IL1A
2 extracellular space GO:0005615 9.4 TNF SLPI OXT IL6 IL1B IL1A

Biological processes related to Vaginal Discharge according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.3 PGR OXT IL6 IL1B IL10 GNRH1
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.21 TNF PTPRN PGR IL6 IL1A IL10
3 positive regulation of transcription, DNA-templated GO:0045893 10.14 TNF IL6 IL1B IL10 ESR1 CD4
4 positive regulation of gene expression GO:0010628 10.04 TNF IL6 IL1B IL1A CXCL8 CRP
5 negative regulation of cell proliferation GO:0008285 10 IL6 IL1B IL1A IL10 GNRH1 CXCL8
6 inflammatory response GO:0006954 9.97 TNF IL6 IL1B IL1A CXCL8 CRP
7 response to lipopolysaccharide GO:0032496 9.94 SLPI IL1B IL10 GNRH1
8 regulation of insulin secretion GO:0050796 9.85 TNF IL6 IL1B
9 response to estradiol GO:0032355 9.85 OXT ESR1 CYP19A1 CD4
10 positive regulation of T cell proliferation GO:0042102 9.84 IL6 IL1B CD4
11 positive regulation of interleukin-8 production GO:0032757 9.83 TNF IL6 IL1B
12 positive regulation of cytokine production GO:0001819 9.83 TNF IL1A IL10
13 response to activity GO:0014823 9.81 OXT IL6 IL10
14 positive regulation of interleukin-6 production GO:0032755 9.81 TNF IL6 IL1B IL1A
15 acute-phase response GO:0006953 9.79 IL6 HP CRP
16 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.78 TNF IL1B IL1A
17 positive regulation of JAK-STAT cascade GO:0046427 9.76 TNF IL6 IL10
18 positive regulation of interleukin-2 production GO:0032743 9.75 IL1B IL1A CD4
19 positive regulation of vascular endothelial growth factor production GO:0010575 9.73 IL6 IL1B IL1A
20 response to glucocorticoid GO:0051384 9.73 TNF OXT IL6 IL10
21 positive regulation of DNA-binding transcription factor activity GO:0051091 9.72 TNF IL6 IL1B IL10 ESR1
22 negative regulation of neurogenesis GO:0050768 9.71 TNF IL6 IL1B
23 regulation of establishment of endothelial barrier GO:1903140 9.68 TNF IL1B
24 positive regulation of prostaglandin secretion GO:0032308 9.68 OXT IL1B
25 endothelial cell apoptotic process GO:0072577 9.67 TNF IL10
26 response to prostaglandin E GO:0034695 9.67 OXT GNRH1
27 negative regulation of cytokine production involved in immune response GO:0002719 9.65 TNF IL10
28 positive regulation of glial cell proliferation GO:0060252 9.65 TNF IL6 IL1B
29 positive regulation of fever generation GO:0031622 9.63 TNF IL1B
30 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 TNF IL1B IL10
31 cellular response to lipopolysaccharide GO:0071222 9.63 TNF IL6 IL1B IL1A IL10 CXCL8
32 positive regulation of immature T cell proliferation in thymus GO:0033092 9.62 IL1B IL1A
33 sequestering of triglyceride GO:0030730 9.62 TNF IL1B
34 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.6 TNF IL1B
35 fever generation GO:0001660 9.59 IL1B IL1A
36 positive regulation of neuroinflammatory response GO:0150078 9.58 TNF IL6 IL1B
37 immune response GO:0006955 9.56 TNF SLPI IL6 IL1B IL1A IL10
38 negative regulation of lipid storage GO:0010888 9.54 TNF IL6 CRP
39 vascular endothelial growth factor production GO:0010573 9.43 TNF IL6 IL1B
40 cytokine-mediated signaling pathway GO:0019221 9.23 TNF PTPRN IL6 IL1B IL1A IL10

Molecular functions related to Vaginal Discharge according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 TNF IL6 IL1B IL1A IL10 CXCL8

Sources for Vaginal Discharge

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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