Aliases & Classifications for Vaginal Disease

MalaCards integrated aliases for Vaginal Disease:

Name: Vaginal Disease 12 15
Vaginal Diseases 43 44 73


External Ids:

Disease Ontology 12 DOID:121
MeSH 44 D014623
NCIt 50 C26910
SNOMED-CT 68 25658005
UMLS 73 C0042251

Summaries for Vaginal Disease

MedlinePlus : 43 Vaginal problems are some of the most common reasons women go to the doctor. They may have symptoms such as Itching Burning Pain Abnormal bleeding Discharge One common problem is vaginitis, an inflammation of the vagina. Other problems that affect the vagina include sexually transmitted diseases, vaginal cancer, and vulvar cancer. Treatment of vaginal problems depends on the cause.

MalaCards based summary : Vaginal Disease, also known as vaginal diseases, is related to vaginal discharge and vaginitis, and has symptoms including pelvic pain and leukorrhea. An important gene associated with Vaginal Disease is EZR (Ezrin), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins. The drugs Metronidazole and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and bone, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A female reproductive system disease that is located in the vagina.

Wikipedia : 76 A vaginal disease is a pathological condition that affects part or all of the... more...

Related Diseases for Vaginal Disease

Diseases related to Vaginal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 vaginal discharge 31.4 EXTL3 HP SPTB
2 vaginitis 30.7 CXCL8 DEFB4A EZR IL1B IL6 LAP3
3 leukoplakia of vagina 10.9
4 exudative glomerulonephritis 10.3 CXCL8 IL1B
5 paraneoplastic syndromes 10.3 IL1B IL6
6 periodontitis, chronic 10.3 IL1B IL6
7 peptic esophagitis 10.3 CXCL8 IL1B
8 acute transverse myelitis 10.3 CXCL8 IL6
9 streptococcal toxic-shock syndrome 10.2 CXCL8 IL6
10 denture stomatitis 10.2 CXCL8 IL6
11 uremic pruritus 10.2 IL1B IL6
12 papillary conjunctivitis 10.2 CXCL8 IL6
13 glossitis 10.2 IL1B IL6
14 haemophilus influenzae 10.2 CXCL8 IL1B
15 laryngitis 10.2 IL1B IL6
16 opisthorchiasis 10.2 CXCL8 IL1B
17 recurrent corneal erosion 10.2 CXCL8 IL1B IL6
18 bagassosis 10.2 CXCL8 IL1B IL6
19 funisitis 10.2 CXCL8 IL1B IL6
20 pulpitis 10.2 CXCL8 IL1B IL6
21 middle ear disease 10.2 CXCL8 IL1B IL6
22 perinatal necrotizing enterocolitis 10.2 CXCL8 IL1B IL6
23 colitis 10.2 CXCL8 IL1B IL6
24 prostatitis 10.2 CXCL8 IL1B IL6
25 euthyroid sick syndrome 10.2 IL1B IL6
26 acute respiratory distress syndrome 10.2 CXCL8 IL1B IL6
27 newborn respiratory distress syndrome 10.2 CXCL8 IL1B IL6
28 pyelonephritis 10.2 CXCL8 IL1B IL6
29 leptospirosis 10.2 CXCL8 IL1B IL6
30 appendicitis 10.2 CXCL8 IL1B IL6
31 pneumonia 10.2 CXCL8 IL1B IL6
32 placenta disease 10.2 CXCL8 IL1B IL6
33 extrinsic allergic alveolitis 10.2 CXCL8 IL1B IL6
34 acute vascular insufficiency of intestine 10.2 IL1B IL6
35 pneumoconiosis 10.2 CXCL8 IL1B IL6
36 aggressive periodontitis 10.2 CXCL8 IL1B IL6
37 periodontitis 10.2 CXCL8 IL1B IL6
38 bacterial meningitis 10.2 CXCL8 IL1B IL6
39 meningitis 10.2 CXCL8 IL1B IL6
40 chorioamnionitis 10.2 CXCL8 IL1B IL6
41 upper respiratory tract disease 10.2 CXCL8 IL1B IL6
42 ascaris lumbricoides infection 10.2 CXCL8 IL1B
43 cardiac rupture 10.2 CXCL8 PRF1
44 esophagitis 10.2 CXCL8 IL1B IL6
45 gastroenteritis 10.2 CXCL8 IL1B IL6
46 contact dermatitis 10.2 CXCL8 IL1B IL6
47 bronchial disease 10.2 CXCL8 IL1B IL6
48 osteomyelitis 10.2 CXCL8 IL1B IL6
49 bone inflammation disease 10.2 CXCL8 IL1B IL6
50 acute monoblastic leukemia 10.2 CXCL8 IL6

Graphical network of the top 20 diseases related to Vaginal Disease:

Diseases related to Vaginal Disease

Symptoms & Phenotypes for Vaginal Disease

UMLS symptoms related to Vaginal Disease:

pelvic pain, leukorrhea

MGI Mouse Phenotypes related to Vaginal Disease:

# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 EZR HP IL1B IL6 PRF1 SLPI
2 immune system MP:0005387 9.32 EZR HP IL1B IL6 LAP3 PRF1

Drugs & Therapeutics for Vaginal Disease

Drugs for Vaginal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 313)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Metronidazole Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 443-48-1 4173
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
Clindamycin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 18323-44-9 29029
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 22916-47-8 4189
Clotrimazole Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 23593-75-1 2812
Desogestrel Approved Phase 4,Phase 2,Phase 3 54024-22-5 40973
Ethinyl Estradiol Approved Phase 4,Phase 2,Phase 3 57-63-6 5991
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-28-2 5757
Polyestradiol phosphate Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 28014-46-2
10 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 979-32-8
Etonogestrel Approved, Investigational Phase 4,Phase 2,Phase 3 54048-10-1 6917715 40976
12 Cranberry Approved, Investigational Phase 4,Not Applicable
Tinidazole Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 19387-91-8 5479
Progesterone Approved, Vet_approved Phase 4,Phase 2,Not Applicable 57-83-0 5994
Nystatin Approved, Vet_approved Phase 4,Phase 3 1400-61-9 11953884
Hyaluronic acid Approved, Vet_approved Phase 4,Not Applicable 9004-61-9 53477741
Fluconazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 86386-73-4 3365
Levonorgestrel Approved, Investigational Phase 4,Not Applicable 17489-40-6, 797-63-7 13109
Copper Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable,Early Phase 1 7440-50-8 27099
Azithromycin Approved Phase 4,Phase 2,Phase 3,Not Applicable 83905-01-5 55185 447043
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
Desflurane Approved Phase 4 57041-67-5 42113
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
Neomycin Approved, Vet_approved Phase 4,Phase 3 1404-04-2 8378
Polihexanide Approved, Investigational Phase 4 28757-47-3
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
Norelgestromin Approved, Investigational Phase 4 53016-31-2 13752005
Dequalinium Approved, Investigational Phase 4,Phase 3 6707-58-0
Terconazole Approved Phase 4,Phase 3,Early Phase 1,Not Applicable 67915-31-5 441383
Norethindrone Approved Phase 4 68-22-4 6230
Medroxyprogesterone acetate Approved, Investigational Phase 4 71-58-9
32 Apricot Approved Phase 4
Norethindrone enanthate Experimental Phase 4 3836-23-5
34 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
35 Antiviral Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
36 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
37 Expectorants Phase 4
38 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
39 Respiratory System Agents Phase 4
40 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable
41 Antioxidants Phase 4
42 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
43 Antidotes Phase 4
44 Free Radical Scavengers Phase 4
45 Protective Agents Phase 4,Phase 2,Not Applicable
46 N-monoacetylcystine Phase 4
47 cysteine Phase 4
48 Clindamycin palmitate Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
49 Acidophilus Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
50 Clindamycin phosphate Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 377)
# Name Status NCT ID Phase Drugs
1 Role of N-Acetylcysteine in Treatment of Bacterial Vaginosis Unknown status NCT01841411 Phase 4 N-Acetyl cysteine;Metronidazole + N-Acetyl cysteine;metronidazole
2 Probiotic Versus Placebo as Adjuvant for Bacterial Vaginosis Treatment During Pregnancy Unknown status NCT01558388 Phase 4 Lactobacillus acidophilus;Placebo
3 Use of Boric Acid in Combination With Probiotics for the Treatment of Vaginal Infections Unknown status NCT02860845 Phase 4 Antibiotic (Clindamycin);Antifungal (Clotrimazole)
4 Effect of the Etonogestrel 0.12mg/Ethinyl Estradiol 0.015mg Vaginal Ring on Vaginal Innate and Inflammatory Biomarkers Unknown status NCT01448291 Phase 4 Etonogestrel /Ethinyl Estradiol Contraceptive Vaginal Ring
5 Probiotics Capsule as Supplemental Therapy for Group B Streptococci Infection and Vaginitis During Pregnancy Unknown status NCT01779193 Phase 4
6 Treatment of Bacterial Vaginosis (BV) With Tinidazole Completed NCT00334633 Phase 4 tinidazole, metronidazole
7 Asymptomatic Bacterial Vaginosis and Herpes Simplex Virus Type 2 (BV/HSV-2) Shedding Study Completed NCT00464542 Phase 4 Metronidazole
8 Treatment of Bacterial Vaginosis Completed NCT00324818 Phase 4 metronidazole and azithromycin
9 Lactoserum (Dermacyd Femina®) and Prevention of Recurrence of Bacterial Vaginosis Completed NCT00556179 Phase 4 Lactoserum (Dermacyd Femina®)
10 Treatment of Bacterial Vaginosis Combined With Human Lactobacilli Completed NCT01245322 Phase 4 lactobacilli
11 Safety and Tolerability of Metronidazole Gel 1.3% Completed NCT02392026 Phase 4 Metronidazole Gel
12 Prevention of Very Preterm Delivery by Testing for and Treatment of Bacterial Vaginosis Completed NCT00642980 Phase 4 Clindamycin;Placebo;Clindamycin
13 Effects of Contraceptive Ring on Vaginal Microbiota, HIV Shedding and Local Immunity Completed NCT02445989 Phase 4 NuvaRing
14 Clindamycin to Reduce Preterm Birth in a Low Resource Setting Completed NCT01800825 Phase 4 Clindamycin;Placebo
15 N-Acetyl Cysteine for Prevention of Preterm Birth Completed NCT00568113 Phase 4 acetylcysteine in arm 1
16 Examining the Impact of Tampon Use on the Vaginal Microbiota Completed NCT03346759 Phase 4
17 Recovery Following Desflurane Versus Sevoflurane for Outpatient Urologic Surgery in Elderly Females Completed NCT01310582 Phase 4 Desflurane;Sevoflurane
18 Open Study of the Efficacy of the Local Treatment With Polygynax of Bacterial and/or Mycotic Vaginitis Completed NCT02444481 Phase 4 Polygynax combinaison of polymyxin, Neomycin and Nystatin
19 Antisepsis Regimen in the Surgical Treatment of Human Papilloma Virus Generated Cervical Lesions: Polyhexamethylene Biguanide Versus Chlorhexidine Completed NCT01740245 Phase 4
20 Oral Low-molecular Weight Hyaluronic Acid in the Treatment of Atrophic Vaginitis Completed NCT02014428 Phase 4 Placebo
21 Comparison of Two Topical Formulations Containing Clindamycin and Clotrimazole in Patients With Vaginal Infections Completed NCT01697826 Phase 4 ClinSupV3 -soft gelatin capsule;ClinSupV3ER- Extended release tablet
22 Vaginal Estrogens Comparative Trial on Pelvic Organ Prolapse Patients Completed NCT03032848 Phase 4 Conjugated Estrogen;Promestriene;Estriol;Vaginal Moisturizer - Cream
23 PARIS or PAtch RIng Study: A Trial to Evaluate NuvaRing Versus OrthoEvra Completed NCT00269620 Phase 4 ethinyl estradiol/etonogestrel vaginal ring;ethinyl estradiol/norelgestromin transdermal contraceptive
24 Epidemiological Study About the Evolution of Patients Treated for an Acute Episode of Vulvovaginal Candidiasis Completed NCT02248506 Phase 4
25 Comparative Efficacy Study of 10 mg Dequalinium Chloride (Fluomizin) in the Treatment of Vulvovaginal Candidiasis Completed NCT02242695 Phase 4 Fluomizin vaginal tablets;Canesten vaginal tablets
26 Clotrimazole Vaginal Tablet vs Fluconazole for Severe Vulvovaginal Candidiasis Completed NCT02180828 Phase 4 Clotrimazole vaginal tablet;Fluconazole
27 Terconazole Vaginal Suppository vs Fluconazole for the Treatment of Severe Vulvovaginal Candidiasis Completed NCT02180100 Phase 4 Terconazole Vaginal Suppository;Fluconazole
28 Effect of Exercise on Spread of the Miconozole Nitrate OVULE in the Vagina Completed NCT00194324 Phase 4 Miconazole nitrate
29 The Efficacy and Safety Study of Clindamycin Palmitate Hydrochloride Dispersible Tablet Treatment of Bacterial Vaginosis Recruiting NCT03080740 Phase 4 Clindamycin palmitate hydrochloride dispersible tablet;Metronidazole Tablet
30 Treatment Comparison of Antibiotics Versus Vaginal Lactic Acid in Non-pregnant Women With Acute Symptomatic Bacterial Vaginosis Recruiting NCT02042287 Phase 4 Metronidazole
31 Oral Metronidazole With Lactobacillus Vaginal Suppositories to Prevent Recurrence of Bacterial Vaginosis Recruiting NCT03099408 Phase 4 Metronidazole Oral;"Metronidazole" and "Lactobacillus"
32 The Effect of Norethisterone Enanthate on Recurrent Bacterial Vaginosis Recruiting NCT02905890 Phase 4 Norethisterone enantate
33 Honghe Fujie Lotion for the Treatment of Bacterial Vaginosis Recruiting NCT03446443 Phase 4 Honghe Fujie lotion;Metronidazole Suppositories
34 Effects of a Vaginal Contraceptive Ring on Vaginal Microbiota and Local Immunity Recruiting NCT02432404 Phase 4 NuvaRing
35 Hormonal Contraceptive Methods on Immunologic Changes in the Female Genital Tract (FGT) and Systemically Recruiting NCT03660046 Phase 4 Depot medroxyprogesterone acetate (DMPA);Etonogestrel implant (Eng-Implant);Levonorgestrel IUD (Lng-IUD)
36 Vaginal and Urinary Microbiome Trial Recruiting NCT02869165 Phase 4 Premarin vaginal cream;Apricot kernel oil
37 Colposeptine for the Treatment of Bacterial Vaginosis Terminated NCT01153958 Phase 4 Colposeptine;Metronidazole
38 Safety and Efficacy Study of Gynevac Lactobacillus Vaccine in the Treatment of Bacterial Vaginosis Unknown status NCT02173184 Phase 3
39 A Pilot Open-label Randomized Study of Lactofiltrum in Women With Bacterial Vaginosis Unknown status NCT01089348 Phase 2, Phase 3 Lactofiltrum + Metronidazole;Metronidazole
40 Bacterial Vaginosis Screening and Treatment to Reduce Infective Complications, Abortion and Preterm Delivery Unknown status NCT00491270 Phase 3
41 Evaluate Efficacy, Tolerability & Safety of Combination of Clindamycin and Ketoconazole for the Treatment of Mixed-Type Vaginosis, Bacterial Vaginosis and Candidiasis Unknown status NCT00889356 Phase 3 Clindamycin 100mg and Ketoconazole 400mg;Tetracycline 100mg and Amphotericin B 50mg
42 The Effect of Probiotics on the Immune Status, Diarrhea and Bacterial Vaginosis Cure Rate Among HIV Patients Unknown status NCT00536848 Phase 2, Phase 3 Metronidazole
43 Va-Sense - Bacterial Vaginosis Once A Week Screening And Treatment To Reduce Infective Complications, Abortion And Preterm Delivery In Pregnant Women With Previous Preterm Delivery Unknown status NCT01152528 Phase 3
44 Efficacy and Safety Study of Metronidazole, Nystatin and Dexamethasone Combination Therapy in Bacterial and Fungal Vaginal Infections Unknown status NCT02186145 Phase 3 Association of metronidazole; nystatin and dexamethasone;Flagyl
45 Maternal Genitourinary Infections and Adverse Perinatal Outcomes Unknown status NCT01572532 Phase 3
46 Saginil in vs. Placebo for Gynecologic Oncology Patients Affected by Vaginitis Unknown status NCT01420510 Phase 2, Phase 3 Adelmidrol vaginal gel;Placebo vaginal gel
47 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
48 Botulinum Toxin Injection for Treatment of Vaginismus Unknown status NCT00638066 Phase 3 botulinum toxin;botulinum toxin A
49 Hyperbaric Oxygen Therapy in Treating Long-Term Gastrointestinal Adverse Effects Caused by Radiation Therapy in Patients With Pelvic Cancer Unknown status NCT01087268 Phase 3
50 Bacterial Vaginosis Home Screening to Prevent STDs Completed NCT00667368 Phase 3 Metronidazole

Search NIH Clinical Center for Vaginal Disease

Cochrane evidence based reviews: vaginal diseases

Genetic Tests for Vaginal Disease

Anatomical Context for Vaginal Disease

MalaCards organs/tissues related to Vaginal Disease:

Lung, Liver, Bone, Lymph Node, Tonsil, Prostate, Placenta

The Foundational Model of Anatomy Ontology organs/tissues related to Vaginal Disease:

The Vagina

Publications for Vaginal Disease

Articles related to Vaginal Disease:

(show all 11)
# Title Authors Year
Global availability of data on HPV genotype-distribution in cervical, vulvar and vaginal disease and genotype-specific prevalence and incidence of HPV infection in females. ( 25987893 )
Subtotal vaginectomy for management of extensive vaginal disease in 11 dogs. ( 22292563 )
Effect of quadrivalent HPV vaccination on HPV related disease in women treated for cervical or vulvar/vaginal disease. ( 22454090 )
Cervical-vaginal disease in HIV immunosuppressed patients: management and present screening programme. ( 16800255 )
Development and evaluation of a suppository formulation containing Lactobacillus and its application in vaginal diseases. ( 16387701 )
Decreased vaginal disease in J-chain-deficient mice following herpes simplex type 2 genital infection. ( 10814580 )
Vaginal disease. Venereal and nonvenereal types. ( 6601795 )
Asymptomatic vaginal disease in pregnancy. ( 4825885 )
Vaginal diseases. ( 6039303 )
Recognition and treatment of vaginal diseases. ( 14943080 )
On the Application of Reflected Light in the Diagnosis and Operative Treatment of Uterine and Vaginal Diseases, with Cases. ( 29612570 )

Variations for Vaginal Disease

Expression for Vaginal Disease

Search GEO for disease gene expression data for Vaginal Disease.

Pathways for Vaginal Disease

Pathways related to Vaginal Disease according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
Show member pathways
11.89 IL1B IL6 TLR7
4 11.84 CXCL8 IL1B IL6
5 11.81 CXCL8 IL1B IL6
6 11.77 CXCL8 IL1B IL6
7 11.73 CXCL8 IL1B IL6
8 11.71 GP5 IL1B IL6
9 11.69 CXCL8 IL1B IL6
10 11.65 CXCL8 IL1B IL6
11 11.62 CXCL8 IL1B IL6
12 11.53 CXCL8 IL1B IL6
13 11.5 IL1B IL6 TLR7
14 11.38 CXCL8 IL1B IL6
Show member pathways
11.34 CXCL8 IL1B IL6
16 11.24 CXCL8 IL1B IL6
Show member pathways
18 11.02 CXCL8 IL1B IL6
19 10.87 CXCL8 IL6
20 10.82 CXCL8 IL1B IL6
21 10.79 CXCL8 EZR IL1B IL6

GO Terms for Vaginal Disease

Cellular components related to Vaginal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 CXCL8 DEFB4A EZR HP IL1B IL6

Biological processes related to Vaginal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.67 CXCL8 IL1B IL6 TLR7
2 defense response GO:0006952 9.58 CXCL8 DEFB4A HP
3 positive regulation of neutrophil chemotaxis GO:0090023 9.43 CXCL8 IL1B
4 positive regulation of interleukin-6 production GO:0032755 9.33 IL1B IL6 TLR7
5 positive regulation of chemokine production GO:0032722 9.32 IL6 TLR7
6 positive regulation of glial cell proliferation GO:0060252 9.26 IL1B IL6
7 immune response GO:0006955 9.1 CXCL8 DEFB4A IL1B IL6 SLPI TLR7
8 positive regulation of neuroinflammatory response GO:0150078 8.96 IL1B IL6

Sources for Vaginal Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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