Aliases & Classifications for Vaginal Disease

MalaCards integrated aliases for Vaginal Disease:

Name: Vaginal Disease 12 15
Vaginal Diseases 43 44 73


External Ids:

Disease Ontology 12 DOID:121
MeSH 44 D014623
NCIt 50 C26910
UMLS 73 C0042251

Summaries for Vaginal Disease

MedlinePlus : 43 Vaginal problems are some of the most common reasons women go to the doctor. They may have symptoms such as Itching Burning Pain Abnormal bleeding Discharge One common problem is vaginitis, an inflammation of the vagina. Other problems that affect the vagina include sexually transmitted diseases, vaginal cancer, and vulvar cancer. Treatment of vaginal problems depends on the cause.

MalaCards based summary : Vaginal Disease, also known as vaginal diseases, is related to cervicitis and vaginitis, and has symptoms including leukorrhea and pelvic pain. An important gene associated with Vaginal Disease is EZR (Ezrin), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Spinal Cord Injury. The drugs Acetylcysteine and Metronidazole have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and uterus, and related phenotype is immune system.

Wikipedia : 76 A vaginal disease is a pathological condition that affects part or all of the... more...

Related Diseases for Vaginal Disease

Diseases related to Vaginal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 cervicitis 30.0 DEFB4A FLNA
2 vaginitis 28.2 CXCL8 DEFB4A EZR IL1B IL6 PRF1
3 systemic onset juvenile idiopathic arthritis 10.8 IL1B PRF1
4 peptic esophagitis 10.8 CXCL8 IL1B
5 periodontitis, chronic 10.8 IL1B IL6
6 acute transverse myelitis 10.8 CXCL8 IL6
7 streptococcal toxic-shock syndrome 10.8 CXCL8 IL6
8 haemophilus influenzae 10.7 CXCL8 IL1B
9 denture stomatitis 10.7 CXCL8 IL6
10 uremic pruritus 10.7 IL1B IL6
11 opisthorchiasis 10.7 CXCL8 IL1B
12 papillary conjunctivitis 10.7 CXCL8 IL6
13 glossitis 10.7 IL1B IL6
14 euthyroid sick syndrome 10.7 IL1B IL6
15 laryngitis 10.7 IL1B IL6
16 cervical incompetence 10.7 IL6 SERPINH1
17 cardiac rupture 10.7 CXCL8 PRF1
18 ascaris lumbricoides infection 10.6 IL1B IL6
19 acute vascular insufficiency of intestine 10.6 IL1B IL6
20 keloid formation 10.6 FLNA IL6
21 recurrent corneal erosion 10.6 CXCL8 IL1B IL6
22 crohn's colitis 10.6 CXCL8 IL1B
23 bagassosis 10.6 CXCL8 IL1B IL6
24 acute monoblastic leukemia 10.6 CXCL8 IL6
25 viral encephalitis 10.6 CXCL8 IL1B IL6
26 prostatitis 10.6 CXCL8 IL1B IL6
27 acute respiratory distress syndrome 10.6 CXCL8 IL1B IL6
28 leptospirosis 10.6 CXCL8 IL1B IL6
29 pyelonephritis 10.6 CXCL8 IL1B IL6
30 appendicitis 10.6 CXCL8 IL1B IL6
31 tonsillitis 10.6 CXCL8 IL1B IL6
32 aggressive periodontitis 10.6 CXCL8 IL1B IL6
33 extrinsic allergic alveolitis 10.6 CXCL8 IL1B IL6
34 poems syndrome 10.6 IL1B IL6
35 chorioamnionitis 10.6 CXCL8 IL1B IL6
36 pneumoconiosis 10.6 CXCL8 IL1B IL6
37 bacterial meningitis 10.6 CXCL8 IL1B IL6
38 esophagitis 10.5 CXCL8 IL1B IL6
39 gastroenteritis 10.5 CXCL8 IL1B IL6
40 autoinflammation, lipodystrophy, and dermatosis syndrome 10.5 CXCL8 IL1B IL6
41 contact dermatitis 10.5 CXCL8 IL1B IL6
42 osteomyelitis 10.5 CXCL8 IL1B IL6
43 chlamydia 10.5 CXCL8 IL1B IL6
44 bone inflammation disease 10.5 CXCL8 IL1B IL6
45 toxic shock syndrome 10.5 CXCL8 IL1B IL6
46 bacteriuria 10.5 CXCL8 IL6 PRF1
47 chronic fatigue syndrome 10.5 CXCL8 IL1B IL6
48 peritonitis 10.5 CXCL8 IL1B IL6
49 respiratory system disease 10.5 CXCL8 IL1B IL6
50 otitis media 10.5 CXCL8 IL1B IL6

Graphical network of the top 20 diseases related to Vaginal Disease:

Diseases related to Vaginal Disease

Symptoms & Phenotypes for Vaginal Disease

UMLS symptoms related to Vaginal Disease:

leukorrhea, pelvic pain

MGI Mouse Phenotypes related to Vaginal Disease:

# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.28 PRF1 SLPI SPTB TXK EZR FLNA

Drugs & Therapeutics for Vaginal Disease

Drugs for Vaginal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 320)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
Metronidazole Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 443-48-1 4173
Clindamycin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 18323-44-9 29029
Desogestrel Approved Phase 4,Phase 2,Phase 3 54024-22-5 40973
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-28-2 5757
6 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 979-32-8
Ethinyl Estradiol Approved Phase 4,Phase 2,Phase 3 57-63-6 5991
Etonogestrel Approved, Investigational Phase 4,Phase 2,Phase 3 54048-10-1 40976 6917715
Polyestradiol phosphate Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 28014-46-2
Tinidazole Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 19387-91-8 5479
Azithromycin Approved Phase 4,Phase 2,Phase 3,Not Applicable 83905-01-5 55185 447043
Progesterone Approved, Vet_approved Phase 4,Phase 2,Not Applicable 57-83-0 5994
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 22916-47-8 4189
Nystatin Approved, Vet_approved Phase 4,Phase 3 1400-61-9 11953884
Hyaluronic acid Approved, Vet_approved Phase 4,Not Applicable 9004-61-9 53477741
Fluconazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 86386-73-4 3365
Desflurane Approved Phase 4 57041-67-5 42113
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
Neomycin Approved, Vet_approved Phase 4,Phase 3 1404-04-2 8378
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
Clotrimazole Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 23593-75-1 2812
Norelgestromin Approved, Investigational Phase 4 53016-31-2 13752005
Dequalinium Approved, Investigational Phase 4,Phase 3 6707-58-0
Terconazole Approved Phase 4,Phase 3,Early Phase 1,Not Applicable 67915-31-5 441383
Loperamide Approved Phase 4 53179-11-6 3955
Mineral oil Approved, Vet_approved Phase 4 8042-47-5
Ephedrine Approved Phase 4,Phase 2,Phase 3 299-42-3 9294
Pseudoephedrine Approved Phase 4,Phase 2,Phase 3 90-82-4 7028
Norethindrone Approved Phase 4 68-22-4 6230
31 Cranberry Approved, Investigational, Nutraceutical Phase 4,Not Applicable
32 Apricot Approved, Nutraceutical Phase 4
33 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
34 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable
35 Antidotes Phase 4
36 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
37 Antioxidants Phase 4
38 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
39 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
40 Antiviral Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
41 Expectorants Phase 4
42 N-monoacetylcystine Phase 4
43 Protective Agents Phase 4,Phase 2,Not Applicable
44 Respiratory System Agents Phase 4,Phase 2,Phase 3
45 Clindamycin palmitate Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
46 Clindamycin phosphate Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
47 Contraceptive Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
48 Contraceptives, Oral Phase 4,Phase 2,Phase 3,Not Applicable
49 Estradiol 17 beta-cypionate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
50 Estradiol 3-benzoate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 360)
# Name Status NCT ID Phase Drugs
1 Role of N-Acetylcysteine in Treatment of Bacterial Vaginosis Unknown status NCT01841411 Phase 4 N-Acetyl cysteine;Metronidazole + N-Acetyl cysteine;metronidazole
2 Probiotic Versus Placebo as Adjuvant for Bacterial Vaginosis Treatment During Pregnancy Unknown status NCT01558388 Phase 4 Lactobacillus acidophilus;Placebo
3 Effect of the Etonogestrel 0.12mg/Ethinyl Estradiol 0.015mg Vaginal Ring on Vaginal Innate and Inflammatory Biomarkers Unknown status NCT01448291 Phase 4 Etonogestrel /Ethinyl Estradiol Contraceptive Vaginal Ring
4 Probiotics Capsule as Supplemental Therapy for Group B Streptococci Infection and Vaginitis During Pregnancy Unknown status NCT01779193 Phase 4
5 Treatment of Bacterial Vaginosis (BV) With Tinidazole Completed NCT00334633 Phase 4 tinidazole, metronidazole
6 Asymptomatic Bacterial Vaginosis and Herpes Simplex Virus Type 2 (BV/HSV-2) Shedding Study Completed NCT00464542 Phase 4 Metronidazole
7 Treatment of Bacterial Vaginosis Completed NCT00324818 Phase 4 metronidazole and azithromycin
8 Lactoserum (Dermacyd Femina®) and Prevention of Recurrence of Bacterial Vaginosis Completed NCT00556179 Phase 4 Lactoserum (Dermacyd Femina®)
9 Treatment of Bacterial Vaginosis Combined With Human Lactobacilli Completed NCT01245322 Phase 4 lactobacilli
10 Safety and Tolerability of Metronidazole Gel 1.3% Completed NCT02392026 Phase 4 Metronidazole Gel
11 Prevention of Very Preterm Delivery by Testing for and Treatment of Bacterial Vaginosis Completed NCT00642980 Phase 4 Clindamycin;Placebo;Clindamycin
12 Clindamycin to Reduce Preterm Birth in a Low Resource Setting Completed NCT01800825 Phase 4 Clindamycin;Placebo
13 N-Acetyl Cysteine for Prevention of Preterm Birth Completed NCT00568113 Phase 4 acetylcysteine in arm 1
14 Examining the Impact of Tampon Use on the Vaginal Microbiota Completed NCT03346759 Phase 4
15 Recovery Following Desflurane Versus Sevoflurane for Outpatient Urologic Surgery in Elderly Females Completed NCT01310582 Phase 4 Desflurane;Sevoflurane
16 Open Study of the Efficacy of the Local Treatment With Polygynax of Bacterial and/or Mycotic Vaginitis Completed NCT02444481 Phase 4 Polygynax combinaison of polymyxin, Neomycin and Nystatin
17 Antisepsis Regimen in the Surgical Treatment of Human Papilloma Virus Generated Cervical Lesions: Polyhexamethylene Biguanide Versus Chlorhexidine Completed NCT01740245 Phase 4
18 Oral Low-molecular Weight Hyaluronic Acid in the Treatment of Atrophic Vaginitis Completed NCT02014428 Phase 4 Placebo
19 Comparison of Two Topical Formulations Containing Clindamycin and Clotrimazole in Patients With Vaginal Infections Completed NCT01697826 Phase 4 ClinSupV3 -soft gelatin capsule;ClinSupV3ER- Extended release tablet
20 Vaginal Estrogens Comparative Trial on Pelvic Organ Prolapse Patients Completed NCT03032848 Phase 4 Conjugated Estrogen;Promestriene;Estriol;Vaginal Moisturizer - Cream
21 PARIS or PAtch RIng Study: A Trial to Evaluate NuvaRing Versus OrthoEvra Completed NCT00269620 Phase 4 ethinyl estradiol/etonogestrel vaginal ring;ethinyl estradiol/norelgestromin transdermal contraceptive
22 Epidemiological Study About the Evolution of Patients Treated for an Acute Episode of Vulvovaginal Candidiasis Completed NCT02248506 Phase 4
23 Comparative Efficacy Study of 10 mg Dequalinium Chloride (Fluomizin) in the Treatment of Vulvovaginal Candidiasis Completed NCT02242695 Phase 4 Fluomizin vaginal tablets;Canesten vaginal tablets
24 Clotrimazole Vaginal Tablet vs Fluconazole for Severe Vulvovaginal Candidiasis Completed NCT02180828 Phase 4 Clotrimazole vaginal tablet;Fluconazole
25 Terconazole Vaginal Suppository vs Fluconazole for the Treatment of Severe Vulvovaginal Candidiasis Completed NCT02180100 Phase 4 Terconazole Vaginal Suppository;Fluconazole
26 The Vaginal Health Trial Completed NCT02516202 Phase 4 Vagifem;Replens
27 Effect of Exercise on Spread of the Miconozole Nitrate OVULE in the Vagina Completed NCT00194324 Phase 4 Miconazole nitrate
28 The Efficacy and Safety Study of Clindamycin Palmitate Hydrochloride Dispersible Tablet Treatment of Bacterial Vaginosis Recruiting NCT03080740 Phase 4 Clindamycin palmitate hydrochloride dispersible tablet;Metronidazole Tablet
29 Treatment Comparison of Antibiotics Versus Vaginal Lactic Acid in Non-pregnant Women With Acute Symptomatic Bacterial Vaginosis Recruiting NCT02042287 Phase 4 Metronidazole
30 Oral Metronidazole With Lactobacillus Vaginal Suppositories to Prevent Recurrence of Bacterial Vaginosis Recruiting NCT03099408 Phase 4 Metronidazole Oral;"Metronidazole" and "Lactobacillus"
31 The Effect of Norethisterone Enanthate on Recurrent Bacterial Vaginosis Recruiting NCT02905890 Phase 4 Norethisterone enantate
32 Honghe Fujie Lotion for the Treatment of Bacterial Vaginosis Recruiting NCT03446443 Phase 4 Honghe Fujie lotion;Metronidazole Suppositories
33 Use of Boric Acid in Combination With Probiotics for the Treatment of Vaginal Infections Recruiting NCT02860845 Phase 4 Antibiotic (Clindamycin);Antifungal (Clotrimazole)
34 Effects of a Vaginal Contraceptive Ring on Vaginal Microbiota and Local Immunity Recruiting NCT02432404 Phase 4 NuvaRing
35 Vaginal and Urinary Microbiome Trial Recruiting NCT02869165 Phase 4 Premarin vaginal cream;Apricot kernel oil
36 Effects of Contraceptive Ring on Vaginal Microbiota, HIV Shedding and Local Immunity Active, not recruiting NCT02445989 Phase 4 NuvaRing
37 Colposeptine for the Treatment of Bacterial Vaginosis Terminated NCT01153958 Phase 4 Colposeptine;Metronidazole
38 Safety and Efficacy Study of Gynevac Lactobacillus Vaccine in the Treatment of Bacterial Vaginosis Unknown status NCT02173184 Phase 3
39 A Pilot Open-label Randomized Study of Lactofiltrum in Women With Bacterial Vaginosis Unknown status NCT01089348 Phase 2, Phase 3 Lactofiltrum + Metronidazole;Metronidazole
40 Bacterial Vaginosis Screening and Treatment to Reduce Infective Complications, Abortion and Preterm Delivery Unknown status NCT00491270 Phase 3
41 Evaluate Efficacy, Tolerability & Safety of Combination of Clindamycin and Ketoconazole for the Treatment of Mixed-Type Vaginosis, Bacterial Vaginosis and Candidiasis Unknown status NCT00889356 Phase 3 Clindamycin 100mg and Ketoconazole 400mg;Tetracycline 100mg and Amphotericin B 50mg
42 The Effect of Probiotics on the Immune Status, Diarrhea and Bacterial Vaginosis Cure Rate Among HIV Patients Unknown status NCT00536848 Phase 2, Phase 3 Metronidazole
43 Va-Sense - Bacterial Vaginosis Once A Week Screening And Treatment To Reduce Infective Complications, Abortion And Preterm Delivery In Pregnant Women With Previous Preterm Delivery Unknown status NCT01152528 Phase 3
44 Medico-economic Impact of Screening Atopobium Vaginae and Gardnerella Vaginalis in Molecular Biology by "Point-of-care" During Pregnancy Unknown status NCT02288832 Phase 2, Phase 3 zithromax
45 Efficacy and Safety Study of Metronidazole, Nystatin and Dexamethasone Combination Therapy in Bacterial and Fungal Vaginal Infections Unknown status NCT02186145 Phase 3 Association of metronidazole; nystatin and dexamethasone;Flagyl
46 Maternal Genitourinary Infections and Adverse Perinatal Outcomes Unknown status NCT01572532 Phase 3
47 Saginil in vs. Placebo for Gynecologic Oncology Patients Affected by Vaginitis Unknown status NCT01420510 Phase 2, Phase 3 Adelmidrol vaginal gel;Placebo vaginal gel
48 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
49 Botulinum Toxin Injection for Treatment of Vaginismus Unknown status NCT00638066 Phase 3 botulinum toxin;botulinum toxin A
50 Hyperbaric Oxygen Therapy in Treating Long-Term Gastrointestinal Adverse Effects Caused by Radiation Therapy in Patients With Pelvic Cancer Unknown status NCT01087268 Phase 3

Search NIH Clinical Center for Vaginal Disease

Cochrane evidence based reviews: vaginal diseases

Genetic Tests for Vaginal Disease

Anatomical Context for Vaginal Disease

MalaCards organs/tissues related to Vaginal Disease:

Testes, Colon, Uterus, Cervix, T Cells, Prostate, Bone

Publications for Vaginal Disease

Articles related to Vaginal Disease:

# Title Authors Year
Global availability of data on HPV genotype-distribution in cervical, vulvar and vaginal disease and genotype-specific prevalence and incidence of HPV infection in females. ( 25987893 )
Subtotal vaginectomy for management of extensive vaginal disease in 11 dogs. ( 22292563 )
Effect of quadrivalent HPV vaccination on HPV related disease in women treated for cervical or vulvar/vaginal disease. ( 22454090 )
Cervical-vaginal disease in HIV immunosuppressed patients: management and present screening programme. ( 16800255 )
Decreased vaginal disease in J-chain-deficient mice following herpes simplex type 2 genital infection. ( 10814580 )
Vaginal disease. Venereal and nonvenereal types. ( 6601795 )
Asymptomatic vaginal disease in pregnancy. ( 4825885 )

Variations for Vaginal Disease

Expression for Vaginal Disease

Search GEO for disease gene expression data for Vaginal Disease.

Pathways for Vaginal Disease

GO Terms for Vaginal Disease

Cellular components related to Vaginal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 CXCL8 DEFB4A EZR IL1B IL6 SERPINH1
2 extracellular region GO:0005576 9.23 CXCL8 DEFB4A DSPP FLNA IL1B IL6
3 cortical cytoskeleton GO:0030863 9.16 EZR FLNA

Biological processes related to Vaginal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.02 CXCL8 DEFB4A IL1B IL6 SLPI
2 positive regulation of leukocyte chemotaxis GO:0002690 8.96 CXCL8 IL6

Sources for Vaginal Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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