MCID: VGN005
MIFTS: 23

Vaginal Endometrial Stromal Sarcoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Vaginal Endometrial Stromal Sarcoma

MalaCards integrated aliases for Vaginal Endometrial Stromal Sarcoma:

Name: Vaginal Endometrial Stromal Sarcoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:5170
NCIt 50 C40270
UMLS 71 C3642329

Summaries for Vaginal Endometrial Stromal Sarcoma

Disease Ontology : 12 A vagina sarcoma that has material basis in endometrial stroma.

MalaCards based summary : Vaginal Endometrial Stromal Sarcoma is related to spindle cell sarcoma and endometrial stromal sarcoma. An important gene associated with Vaginal Endometrial Stromal Sarcoma is JAZF1 (JAZF Zinc Finger 1), and among its related pathways/superpathways are Tyrosine Kinases / Adaptors and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Related phenotypes are cellular and integument

Related Diseases for Vaginal Endometrial Stromal Sarcoma

Diseases related to Vaginal Endometrial Stromal Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 234)
# Related Disease Score Top Affiliating Genes
1 spindle cell sarcoma 29.7 VIM KIT CD34 CALD1
2 endometrial stromal sarcoma 28.4 YWHAE VIM SUZ12 PHF1 PGR MME
3 vaginal endometrial stromal tumor 10.3 MME CALD1
4 mixed endometrial stromal and smooth muscle tumor 10.3 MME CALD1
5 fallopian tube leiomyoma 10.3 MME CALD1
6 fallopian tube benign neoplasm 10.3 MME CALD1
7 sarcoma 10.3
8 endometriosis 10.3
9 subareolar duct papillomatosis 10.3 MME CALD1
10 lung combined type small cell carcinoma 10.3 MME CALD1
11 cervical mucinous adenocarcinoma 10.3 MME CALD1
12 nipple benign neoplasm 10.3 MME CALD1
13 uterus perivascular epithelioid cell tumor 10.2 MME CALD1
14 atypical polypoid adenomyoma 10.2 MME CALD1
15 heart lymphoma 10.2 VIM MME
16 diffuse peritoneal leiomyomatosis 10.2 PGR CALD1
17 lung leiomyoma 10.2 PGR CALD1
18 bizarre leiomyoma 10.2 PGR CALD1
19 lymphangiomatosis 10.2 VIM PGR
20 myofibroma 10.2 CD34 CALD1
21 congenital epulis 10.2 VIM PGR
22 epulis 10.2 VIM PGR
23 intravascular angioleiomyoma 10.2 CD34 CALD1
24 endometrial mucinous adenocarcinoma 10.2 VIM PGR
25 benign metastasizing leiomyoma 10.2 VIM PGR
26 cervical adenomyoma 10.2 PGR MME
27 cervical benign neoplasm 10.2 PGR MME
28 ossifying fibromyxoid tumor 10.2 VIM PHF1
29 uterine corpus adenosarcoma 10.1 PGR MME
30 fallopian tube endometriosis 10.1 PGR MME
31 glomangiosarcoma 10.1 CD34 CALD1
32 cervical serous adenocarcinoma 10.1 PGR MME
33 adult fibrosarcoma 10.1 CD34 CALD1
34 testicular fibroma 10.1 CD34 CALD1
35 odontogenic myxoma 10.1 VIM IGF1R
36 congenital granular cell tumor 10.1 CD34 CALD1
37 subungual glomus tumor 10.1 CD34 CALD1
38 ovarian sex-cord stromal tumor 10.1 SUZ12 MME JAZF1
39 infiltrating angiolipoma 10.1 CD34 CALD1
40 intravascular fasciitis 10.1 CD34 CALD1
41 constipation 10.1
42 breast metaplastic carcinoma 10.1 PGR MME
43 extraosseous osteosarcoma 10.1 CD34 CALD1
44 pediatric liposarcoma 10.1 VIM CD34
45 malignant mesenchymoma 10.1 CD34 CALD1
46 benign pleural mesothelioma 10.1 STAT6 CD34
47 biphasic synovial sarcoma 10.1 VIM PGR
48 pancreatic mucinous cystadenoma 10.1 PGR MME
49 atypical neurofibroma 10.1 SUZ12 CD34
50 cutaneous adenocystic carcinoma 10.1 PGR MME

Graphical network of the top 20 diseases related to Vaginal Endometrial Stromal Sarcoma:



Diseases related to Vaginal Endometrial Stromal Sarcoma

Symptoms & Phenotypes for Vaginal Endometrial Stromal Sarcoma

MGI Mouse Phenotypes related to Vaginal Endometrial Stromal Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.91 CD34 IGF1R KIT MME PGR STAT6
2 integument MP:0010771 9.7 CD34 IGF1R KIT MME PGR STAT6
3 neoplasm MP:0002006 9.43 CD34 IGF1R KIT PGR STAT6 SUZ12
4 reproductive system MP:0005389 9.17 IGF1R JAZF1 KIT PGR STAT6 VIM

Drugs & Therapeutics for Vaginal Endometrial Stromal Sarcoma

Search Clinical Trials , NIH Clinical Center for Vaginal Endometrial Stromal Sarcoma

Genetic Tests for Vaginal Endometrial Stromal Sarcoma

Anatomical Context for Vaginal Endometrial Stromal Sarcoma

Publications for Vaginal Endometrial Stromal Sarcoma

Articles related to Vaginal Endometrial Stromal Sarcoma:

# Title Authors PMID Year
1
Vaginal endometrial stromal sarcoma: A literature review. 61
31528854 2019
2
Primary low-grade endometrial stromal sarcoma arising in the vagina: report of an unusual case and literature review. 61
29218216 2017
3
Primary vaginal endometrial stromal sarcoma associated with endometriosis: a case report with a review of the literature. 61
29787018 2016

Variations for Vaginal Endometrial Stromal Sarcoma

Expression for Vaginal Endometrial Stromal Sarcoma

Search GEO for disease gene expression data for Vaginal Endometrial Stromal Sarcoma.

Pathways for Vaginal Endometrial Stromal Sarcoma

Pathways related to Vaginal Endometrial Stromal Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.6 YWHAE KIT IGF1R
2 11.4 MME KIT CD34
3 11.13 MME KIT CD34
4 10.77 YWHAE IGF1R
5 10.67 MME KIT CD34

GO Terms for Vaginal Endometrial Stromal Sarcoma

Cellular components related to Vaginal Endometrial Stromal Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ESC/E(Z) complex GO:0035098 8.62 SUZ12 PHF1

Biological processes related to Vaginal Endometrial Stromal Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amyloid-beta clearance GO:0097242 8.96 MME IGF1R
2 paracrine signaling GO:0038001 8.62 PGR CD34

Molecular functions related to Vaginal Endometrial Stromal Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.43 YWHAE VIM STAT6 PHF1 PGR IGF1R
2 RNA polymerase II transcription corepressor binding GO:0001226 8.62 SUZ12 PHF1

Sources for Vaginal Endometrial Stromal Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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