Aliases & Classifications for Vaginitis

MalaCards integrated aliases for Vaginitis:

Name: Vaginitis 12 43 44 15 73
Infective Vaginitis 73


External Ids:

Disease Ontology 12 DOID:2170
ICD9CM 35 616.1 616.10
MeSH 44 D014627
NCIt 50 C26911
SNOMED-CT 68 30800001

Summaries for Vaginitis

MedlinePlus : 43 What is vaginitis? Vaginitis, also called vulvovaginitis, is an inflammation or infection of the vagina. It can also affect the vulva, which is the external part of a woman's genitals. Vaginitis can cause itching, pain, discharge, and odor. Vaginitis is common, especially in women in their reproductive years. It usually happens when there is a change in the balance of bacteria or yeast that are normally found in your vagina. There are different types of vaginitis, and they have different causes, symptoms, and treatments. What are the different causes of vaginitis? Bacterial vaginosis (BV) is the most common vaginal infection in women ages 15-44. It happens when there is an imbalance between the "good" and "harmful" bacteria that are normally found in a woman's vagina. Many things can change the balance of bacteria, including Taking antibiotics Douching Using an intrauterine device (IUD) Having unprotected sex with a new partner Having many sexual partners Yeast infections (candidiasis) happen when too much candida grows in the vagina. Candida is the scientific name for yeast. It is a fungus that lives almost everywhere, including in your body. You may have too much growing in the vagina because of Antibiotics Pregnancy Diabetes, especially if it is not well-controlled Corticosteroid medicines Trichomoniasis can also cause vaginitis. Trichomoniasis is a common sexually transmitted disease. It is caused by a parasite. You can also have vaginitis if you are allergic or sensitive to certain products that you use. Examples include vaginal sprays, douches, spermicides, soaps, detergents, or fabric softeners. They can cause burning, itching, and discharge. Hormonal changes can also cause vaginal irritation. Examples are when you are pregnant or breastfeeding, or when you have gone through menopause. Sometimes you can have more than one cause of vaginitis at the same time. What are the symptoms of vaginitis? The symptoms of vaginitis depend on which type you have. With BV, you may not have symptoms. You could have a thin white or gray vaginal discharge. There may be an odor, such as a strong fish-like odor, especially after sex. Yeast infections produce a thick, white discharge from the vagina that can look like cottage cheese. The discharge can be watery and often has no smell. Yeast infections usually cause the vagina and vulva to become itchy and red. You may not have symptoms when you have trichomoniasis. If you do have them, they include itching, burning, and soreness of the vagina and vulva. You may have burning during urination. You could also have gray-green discharge, which may smell bad. How is the cause of vaginitis diagnosed? To find out the cause of your symptoms, your health care provider may Ask you about your health history Do a pelvic exam Look for vaginal discharge, noting its color, qualities, and any odor Study a sample of your vaginal fluid under a microscope In some cases, you may need more tests. What are the treatments for vaginitis? The treatment depends on which type of vaginitis you have. BV is treatable with antibiotics. You may get pills to swallow, or cream or gel that you put in your vagina. During treatment, you should use a condom during sex or not have sex at all. Yeast infections are usually treated with a cream or with medicine that you put inside your vagina. You can buy over-the-counter treatments for yeast infections, but you need to be sure that you do have a yeast infection and not another type of vaginitis. See your health care provider if this is the first time you have had symptoms. Even if you have had yeast infections before, it is a good idea to call your health care provider before using an over-the-counter treatment. The treatment for trichomoniasis is usually a single-dose antibiotic. Both you and your partner(s) should be treated, to prevent spreading the infection to others and to keep from getting it again. If your vaginitis is due to an allergy or sensitivity to a product, you need to figure out which product is causing the problem. It could be a product that you started using recently. Once you figure it out, you should stop using the product. If the cause of your vaginitis is a hormonal change, your health care provider may give you estrogen cream to help with your symptoms. Can vaginitis cause other health problems? It is important to treat BV and trichomoniasis, because having either of them can increase your risk for getting HIV or another sexually transmitted disease. If you are pregnant, BV or trichomoniasis can increase your risk for preterm labor and preterm birth. How can I prevent vaginitis? To help prevent vaginitis Do not douche or use vaginal sprays Use a condom when having sex Avoid clothes that hold in heat and moisture Wear cotton underwear

MalaCards based summary : Vaginitis, also known as infective vaginitis, is related to postmenopausal atrophic vaginitis and trichomoniasis, and has symptoms including leukorrhea, vaginal pruritus and vaginal odor. An important gene associated with Vaginitis is ESR1 (Estrogen Receptor 1), and among its related pathways/superpathways are Allograft rejection and Pathways in cancer. The drugs Cranberry and Clindamycin have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and prostate, and related phenotypes are cardiovascular system and growth/size/body region

Disease Ontology : 12 A vaginal disease that is characterized by inflammation of the vagina.

Wikipedia : 76 Vaginitis, also known as vulvovaginitis, is inflammation of the vagina and vulva. Symptoms may include... more...

Related Diseases for Vaginitis

Diseases related to Vaginitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 695)
# Related Disease Score Top Affiliating Genes
1 postmenopausal atrophic vaginitis 34.1 AR ESR1 ESR2
2 trichomoniasis 32.5 CXCL8 LAP3
3 vaginal disease 32.1 CXCL8 DEFB4A EZR IL1B IL6 LAP3
4 endometritis 31.9 ESR1 IL1B IL6
5 chlamydia 31.9 CXCL8 IL1B IL6
6 chorioamnionitis 31.8 CXCL8 IL1B IL6
7 bacterial vaginosis 31.4 CXCL8 DEFB4A IL1B IL6 LAP3 PRF1
8 female reproductive system disease 31.4 CXCL8 ESR1 ESR2 IL6
9 cervicitis 30.3 CXCL8 DEFB4A
10 toxic shock syndrome 30.1 CXCL8 IL1B IL6
11 endometriosis 30.1 CXCL8 ESR1 ESR2 IL1B IL6
12 preterm premature rupture of the membranes 30.0 CXCL8 IL1B IL6 SPTB
13 peritonitis 30.0 CXCL8 IL1B IL6
14 vulvar vestibulitis syndrome 29.8 ESR1 IL1B
15 endometrial stromal sarcoma 29.8 CXCL8 ESR1 IL6
16 estrogen excess 29.6 ESR1 ESR2
17 endometrial disease 29.6 CXCL8 ESR1 IL1B IL6
18 colitis 29.6 ABCB1 CXCL8 IL1B IL6
19 viral infectious disease 29.6 CXCL8 IL1B IL6
20 pneumonia 29.5 CXCL8 IL1B IL6
21 placenta disease 29.5 CXCL8 IL1B IL6
22 meningitis 29.5 CXCL8 IL1B IL6
23 haemophilus influenzae 29.5 CXCL8 IL1B
24 bacteriuria 29.5 CXCL8 IL6 PRF1
25 streptococcal toxic-shock syndrome 29.4 CXCL8 IL6
26 ulcerative colitis 29.4 ABCB1 CXCL8 IL1B IL6
27 osteoporosis 29.3 AR ESR1 ESR2 IL1B IL6
28 prostatitis 29.3 CXCL8 IL1B IL6
29 pyelonephritis 29.3 CXCL8 IL1B IL6
30 leptospirosis 29.3 CXCL8 IL1B IL6
31 appendicitis 29.3 CXCL8 IL1B IL6
32 contact dermatitis 29.3 CXCL8 IL1B IL6
33 behcet syndrome 29.1 CXCL8 IL1B IL6
34 bacterial infectious disease 29.0 CXCL8 DEFB4A IL1B IL6
35 gingivitis 28.8 CXCL8 DEFB4A IL1B IL6
36 vaginal cancer 12.6
37 vaginal discharge 12.5
38 vaginal atresia 12.4
39 vaginal yolk sac tumor 12.4
40 vaginal adenosarcoma 12.3
41 vaginal carcinosarcoma 12.3
42 vaginal mullerian papilloma 12.2
43 vaginal adenoma 12.2
44 vaginal tubulovillous adenoma 12.2
45 vaginal glandular tumor 12.2
46 vaginal squamous papilloma 12.2
47 vaginal squamous tumor 12.2
48 vaginal villous adenoma 12.2
49 vaginal tubular adenoma 12.2
50 benign vaginal carcinosarcoma 12.1

Graphical network of the top 20 diseases related to Vaginitis:

Diseases related to Vaginitis

Symptoms & Phenotypes for Vaginitis

UMLS symptoms related to Vaginitis:

leukorrhea, vaginal pruritus, vaginal odor, vaginal discomfort, vaginal pain or burning

MGI Mouse Phenotypes related to Vaginitis:

# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 ABCB1 AR ESR1 ESR2 IL1B IL6
2 growth/size/body region MP:0005378 10.02 ABCB1 AR ESR1 ESR2 EZR IL1B
3 hematopoietic system MP:0005397 10.02 ABCB1 AR ESR1 ESR2 EZR IL1B
4 immune system MP:0005387 10 ABCB1 AR ESR1 ESR2 EZR IL1B
5 digestive/alimentary MP:0005381 9.88 ABCB1 AR ESR1 ESR2 EZR IL6
6 liver/biliary system MP:0005370 9.7 ABCB1 AR ESR1 ESR2 IL6 PRF1
7 neoplasm MP:0002006 9.43 AR ESR1 ESR2 IL1B IL6 PRF1
8 reproductive system MP:0005389 9.17 ABCB1 AR ESR1 ESR2 IL6 PRF1

Drugs & Therapeutics for Vaginitis

Drugs for Vaginitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 183)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cranberry Approved, Investigational Phase 4,Not Applicable
Clindamycin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 18323-44-9 29029
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 22916-47-8 4189
Clotrimazole Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 23593-75-1 2812
Desogestrel Approved Phase 4 54024-22-5 40973
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-28-2 5757
Polyestradiol phosphate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 28014-46-2
9 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 979-32-8
Etonogestrel Approved, Investigational Phase 4 54048-10-1 6917715 40976
Metronidazole Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 443-48-1 4173
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
Nystatin Approved, Vet_approved Phase 4,Phase 3 1400-61-9 11953884
Azithromycin Approved Phase 4,Phase 3,Not Applicable 83905-01-5 55185 447043
Fluconazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 86386-73-4 3365
Neomycin Approved, Vet_approved Phase 4,Phase 3 1404-04-2 8378
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
Tinidazole Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 19387-91-8 5479
Dequalinium Approved, Investigational Phase 4,Phase 3 6707-58-0
Terconazole Approved Phase 4,Phase 3,Early Phase 1,Not Applicable 67915-31-5 441383
22 Apricot Approved Phase 4
Norethindrone Approved Phase 4 68-22-4 6230
Norethindrone enanthate Experimental Phase 4 3836-23-5
25 Acidophilus Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
26 Antibiotics, Antitubercular Phase 4,Phase 2,Not Applicable
27 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
28 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
29 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
30 Clindamycin palmitate Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
31 Antitubercular Agents Phase 4,Not Applicable
32 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
33 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
34 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
35 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
36 Clindamycin phosphate Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
37 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
38 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
39 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
40 Estrogens Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Estradiol 3-benzoate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Contraceptive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Contraceptives, Oral Phase 4,Phase 3
44 Progestins Phase 4,Phase 2
45 Estradiol 17 beta-cypionate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
47 Antiviral Agents Phase 4,Not Applicable
48 Expectorants Phase 4
49 Respiratory System Agents Phase 4
50 Antioxidants Phase 4

Interventional clinical trials:

(show top 50) (show all 254)
# Name Status NCT ID Phase Drugs
1 Probiotics Capsule as Supplemental Therapy for Group B Streptococci Infection and Vaginitis During Pregnancy Unknown status NCT01779193 Phase 4
2 Use of Boric Acid in Combination With Probiotics for the Treatment of Vaginal Infections Unknown status NCT02860845 Phase 4 Antibiotic (Clindamycin);Antifungal (Clotrimazole)
3 Effect of the Etonogestrel 0.12mg/Ethinyl Estradiol 0.015mg Vaginal Ring on Vaginal Innate and Inflammatory Biomarkers Unknown status NCT01448291 Phase 4 Etonogestrel /Ethinyl Estradiol Contraceptive Vaginal Ring
4 Role of N-Acetylcysteine in Treatment of Bacterial Vaginosis Unknown status NCT01841411 Phase 4 N-Acetyl cysteine;Metronidazole + N-Acetyl cysteine;metronidazole
5 Probiotic Versus Placebo as Adjuvant for Bacterial Vaginosis Treatment During Pregnancy Unknown status NCT01558388 Phase 4 Lactobacillus acidophilus;Placebo
6 Open Study of the Efficacy of the Local Treatment With Polygynax of Bacterial and/or Mycotic Vaginitis Completed NCT02444481 Phase 4 Polygynax combinaison of polymyxin, Neomycin and Nystatin
7 Oral Low-molecular Weight Hyaluronic Acid in the Treatment of Atrophic Vaginitis Completed NCT02014428 Phase 4 Placebo
8 Comparison of Two Topical Formulations Containing Clindamycin and Clotrimazole in Patients With Vaginal Infections Completed NCT01697826 Phase 4 ClinSupV3 -soft gelatin capsule;ClinSupV3ER- Extended release tablet
9 Vaginal Estrogens Comparative Trial on Pelvic Organ Prolapse Patients Completed NCT03032848 Phase 4 Conjugated Estrogen;Promestriene;Estriol;Vaginal Moisturizer - Cream
10 Periodical Presumptive Treatment for the Control of Gonococcal Infections Among Sex Workers Completed NCT01329588 Phase 4 Monthly antibiotic;Monthly placebo
11 Effects of Contraceptive Ring on Vaginal Microbiota, HIV Shedding and Local Immunity Completed NCT02445989 Phase 4 NuvaRing
12 Safety and Tolerability of Metronidazole Gel 1.3% Completed NCT02392026 Phase 4 Metronidazole Gel
13 Treatment of Bacterial Vaginosis Combined With Human Lactobacilli Completed NCT01245322 Phase 4 lactobacilli
14 Treatment of Bacterial Vaginosis (BV) With Tinidazole Completed NCT00334633 Phase 4 tinidazole, metronidazole
15 Treatment of Bacterial Vaginosis Completed NCT00324818 Phase 4 metronidazole and azithromycin
16 Lactoserum (Dermacyd Femina®) and Prevention of Recurrence of Bacterial Vaginosis Completed NCT00556179 Phase 4 Lactoserum (Dermacyd Femina®)
17 Prevention of Very Preterm Delivery by Testing for and Treatment of Bacterial Vaginosis Completed NCT00642980 Phase 4 Clindamycin;Placebo;Clindamycin
18 Clindamycin to Reduce Preterm Birth in a Low Resource Setting Completed NCT01800825 Phase 4 Clindamycin;Placebo
19 Epidemiological Study About the Evolution of Patients Treated for an Acute Episode of Vulvovaginal Candidiasis Completed NCT02248506 Phase 4
20 Comparative Efficacy Study of 10 mg Dequalinium Chloride (Fluomizin) in the Treatment of Vulvovaginal Candidiasis Completed NCT02242695 Phase 4 Fluomizin vaginal tablets;Canesten vaginal tablets
21 Clotrimazole Vaginal Tablet vs Fluconazole for Severe Vulvovaginal Candidiasis Completed NCT02180828 Phase 4 Clotrimazole vaginal tablet;Fluconazole
22 Terconazole Vaginal Suppository vs Fluconazole for the Treatment of Severe Vulvovaginal Candidiasis Completed NCT02180100 Phase 4 Terconazole Vaginal Suppository;Fluconazole
23 Effect of Exercise on Spread of the Miconozole Nitrate OVULE in the Vagina Completed NCT00194324 Phase 4 Miconazole nitrate
24 Asymptomatic Bacterial Vaginosis and Herpes Simplex Virus Type 2 (BV/HSV-2) Shedding Study Completed NCT00464542 Phase 4 Metronidazole
25 Honghe Fujie Lotion for the Treatment of Bacterial Vaginosis Recruiting NCT03446443 Phase 4 Honghe Fujie lotion;Metronidazole Suppositories
26 Vaginal and Urinary Microbiome Trial Recruiting NCT02869165 Phase 4 Premarin vaginal cream;Apricot kernel oil
27 Treatment Comparison of Antibiotics Versus Vaginal Lactic Acid in Non-pregnant Women With Acute Symptomatic Bacterial Vaginosis Recruiting NCT02042287 Phase 4 Metronidazole
28 The Efficacy and Safety Study of Clindamycin Palmitate Hydrochloride Dispersible Tablet Treatment of Bacterial Vaginosis Recruiting NCT03080740 Phase 4 Clindamycin palmitate hydrochloride dispersible tablet;Metronidazole Tablet
29 The Effect of Norethisterone Enanthate on Recurrent Bacterial Vaginosis Recruiting NCT02905890 Phase 4 Norethisterone enantate
30 Effects of a Vaginal Contraceptive Ring on Vaginal Microbiota and Local Immunity Recruiting NCT02432404 Phase 4 NuvaRing
31 Oral Metronidazole With Lactobacillus Vaginal Suppositories to Prevent Recurrence of Bacterial Vaginosis Recruiting NCT03099408 Phase 4 Metronidazole Oral;"Metronidazole" and "Lactobacillus"
32 Colposeptine for the Treatment of Bacterial Vaginosis Terminated NCT01153958 Phase 4 Colposeptine;Metronidazole
33 Saginil in vs. Placebo for Gynecologic Oncology Patients Affected by Vaginitis Unknown status NCT01420510 Phase 2, Phase 3 Adelmidrol vaginal gel;Placebo vaginal gel
34 Safety and Efficacy Study of Gynevac Lactobacillus Vaccine in the Treatment of Bacterial Vaginosis Unknown status NCT02173184 Phase 3
35 A Pilot Open-label Randomized Study of Lactofiltrum in Women With Bacterial Vaginosis Unknown status NCT01089348 Phase 2, Phase 3 Lactofiltrum + Metronidazole;Metronidazole
36 Efficacy and Safety Study of Metronidazole, Nystatin and Dexamethasone Combination Therapy in Bacterial and Fungal Vaginal Infections Unknown status NCT02186145 Phase 3 Association of metronidazole; nystatin and dexamethasone;Flagyl
37 Evaluate Efficacy, Tolerability & Safety of Combination of Clindamycin and Ketoconazole for the Treatment of Mixed-Type Vaginosis, Bacterial Vaginosis and Candidiasis Unknown status NCT00889356 Phase 3 Clindamycin 100mg and Ketoconazole 400mg;Tetracycline 100mg and Amphotericin B 50mg
38 Bacterial Vaginosis Screening and Treatment to Reduce Infective Complications, Abortion and Preterm Delivery Unknown status NCT00491270 Phase 3
39 Va-Sense - Bacterial Vaginosis Once A Week Screening And Treatment To Reduce Infective Complications, Abortion And Preterm Delivery In Pregnant Women With Previous Preterm Delivery Unknown status NCT01152528 Phase 3
40 The Effect of Probiotics on the Immune Status, Diarrhea and Bacterial Vaginosis Cure Rate Among HIV Patients Unknown status NCT00536848 Phase 2, Phase 3 Metronidazole
41 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
42 Assessment of the Efficacy of POLYGYNAX® in the Empirical Treatment of Infectious Vaginitis Completed NCT02515656 Phase 3 POLYGYNAX®;GYNODAKTARIN®;Placebo
43 Study Evaluating Conjugated Estrogen Cream for Atrophic Vaginitis Completed NCT00137371 Phase 3 PVC (daily for 21 days, 7 days off);PVC (twice weekly)
44 Study to Evaluate Equivalence of Estradiol Vaginal Cream 0.01% to Estrace® Cream 0.01% in Atrophic Vaginitis Completed NCT03294538 Phase 3 Estrace® Cream;Generic Estradiol Cream;Vehicle Cream
45 A Study to Compare Efficacy and Safety of an Ovule Containing Terconazole, Clindamycin and Fluocinolone Versus an Ovule Containing Metronidazole, Nystatin and Fluocinolone in the Treatment of Secondary Vulvar/ or Vaginal Symptoms of Infectious Vaginitis/ and Infectious Vaginosis Completed NCT01867164 Phase 3 Gynoclin V;Vagitrol V
46 A Multi-Site Study Comparing Estradiol Vaginal Cream (0.01%) to Estrace® Cream (0.01%) in Postmenopausal Females With Atrophic Vaginitis Completed NCT02995694 Phase 3 Estradiol;Placebos;Reference
47 A Comparison of Estradiol Vaginal Cream to Estrace® Cream in 350 Postmenopausal Females With Atrophic Vaginitis Completed NCT02195986 Phase 3 Estradiol Vaginal Cream, 0.01%;Estrace® 0.01% cream;Placebo Vaginal Cream
48 Evaluation of Safety and Efficacy of 17-Beta Estradiol in Treatment of Atrophic Vaginitis: An Extension Trial Completed NCT00464971 Phase 3 estradiol, 25 mcg
49 Endometrial Safety of a Low Dose of Vagifem® in Postmenopausal Women With Atrophic Vaginitis Completed NCT00431132 Phase 3 estradiol, 10 mcg
50 Vagifem Low Dose for Postmenopausal Atrophic Vaginitis Symptoms Completed NCT00108849 Phase 3 estradiol, 10 mcg

Search NIH Clinical Center for Vaginitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :

Cochrane evidence based reviews: vaginitis

Genetic Tests for Vaginitis

Anatomical Context for Vaginitis

MalaCards organs/tissues related to Vaginitis:

Testes, Colon, Prostate, Ovary, B Cells, Placenta, Uterus

Publications for Vaginitis

Articles related to Vaginitis:

(show top 50) (show all 1033)
# Title Authors Year
Vaginal Microbiomes Associated With Aerobic Vaginitis and Bacterial Vaginosis. ( 29632854 )
Inguinal Hyperhidrosis: Case Report of an Uncommon Cause of Vaginitis. ( 29421341 )
Prevention practices of vaginitis among Malaysian women and its associated factors. ( 29526143 )
Is non-response to fluconazole maintenance therapy for recurrent Candida vaginitis related to sensitization to atopic reactions? ( 29469170 )
Abnormal vaginal microbioma is associated with severity of localized provoked vulvodynia. Role of aerobic vaginitis and Candida in the pathogenesis of vulvodynia. ( 29934834 )
Diagnostic Performance of a Molecular Test versus Clinician Assessment of Vaginitis. ( 29643195 )
Iron restriction to clinical isolates of <i>Candida albicans</i> by the novel chelator DIBI inhibits growth and increases sensitivity to azoles <i>in vitro</i> and <i>in vivo</i> in a murine model of experimental vaginitis. ( 29844048 )
Candida vaginitis: virulence, host response and vaccine prospects. ( 29538739 )
Vaginitis. ( 29671518 )
Therapeutic Approaches to Atrophic Vaginitis in Postmenopausal Women: A Systematic Review with a Network Meta-analysis of Randomized Controlled Trials. ( 29765921 )
Vaginitis: Diagnosis and Treatment. ( 29671516 )
Efficacy and safety of combined high-dose interferon and red light therapy for the treatment of human papillomavirus and associated vaginitis and cervicitis: A prospective and randomized clinical study. ( 30213012 )
Application of conjugated estrogen cream in the treatment of postmenopausal atrophic vaginitis. ( 30463825 )
Sexual behaviour and extra-genital colonisation in women treated for recurrent Candida vulvo-vaginitis. ( 29998617 )
Effect of vaginal suppository on bacterial vaginitis based on Persian medicine (Iranian traditional medicine): a randomised double blind clinical study. ( 30084707 )
Molecular-based Testing for Sexually Transmitted Infections Using Samples Previously Collected for Vaginitis Diagnosis. ( 30084883 )
Effect of pea protein plus grape seed dry extract on a murine model of Candida albicans induced vaginitis. ( 30256168 )
17β-estradiol vaginal tablet versus conjugated equine estrogen vaginal cream to relieve menopausal atrophic vaginitis. ( 30358715 )
Calophyllum inophyllum in vaginitis treatment: Stimulated by electroporation with an in vitro approach. ( 30465335 )
Aerobic vaginitis in late pregnancy and outcomes of pregnancy. ( 30467614 )
Tyndallized lactic ferments: new possible therapies in treating vaginitis. ( 28116891 )
Overexpression of Candida albicans Secreted Aspartyl Proteinases 2 or 5 is not sufficient for exacerbation of immunopathology in a murine model of vaginitis. ( 28760935 )
Effect of the vaginal pessaries MelanizolAr and KlimedeksAr on the glycogen level in the vaginal tissue of rats on the background of experimental vaginitis. ( 28914070 )
Loop-Mediated Isothermal Amplification on Crude DNA as a Point-of-Care Test for the Diagnosis of Mycoplasma-Related Vaginitis During Early Pregnancy. ( 29272448 )
Clinical Validation of a Test for the Diagnosis of Vaginitis. ( 28594779 )
Aerobic vaginitis: no longer a stranger. ( 28502874 )
Vaginitis ( 29262024 )
Clinical Validation of a Test for the Diagnosis of Vaginitis. ( 28937557 )
Highly efficient treatment of aerobic vaginitis with simple acidic buffered gels: The importance of pH and buffers on the microenvironment of vaginas. ( 28414136 )
Chitosan Ascorbate Nanoparticles for the Vaginal Delivery of Antibiotic Drugs in Atrophic Vaginitis. ( 29048359 )
Cervical Ectropion May Be a Cause of Desquamative Inflammatory Vaginitis. ( 28460993 )
An epidemiological study on vaginitis in 6,150 women of reproductive age in Shanghai. ( 28255605 )
The Threat of Aerobic Vaginitis to Pregnancy and Neonatal Morbidity. ( 29624945 )
Determination of factors affecting relapse of vaginitis among reproductive-aged women: An experimental study. ( 28243399 )
Vaginitis: Beyond the Basics. ( 28499528 )
Role of Molecular Biology in Diagnosis and Characterization of Vulvo-Vaginitis in Clinical Practice. ( 29017160 )
Syndromic Diagnosis in Evaluation of Women with Symptoms of Vaginitis. ( 28210940 )
Prevalence of vaginitis in different age groups among females in Greece. ( 28468531 )
Treatment of refractory Candida krusei vaginitis with topical amphotericin B. ( 27567339 )
Diagnosis and microecological characteristics of aerobic vaginitis in outpatients based on preformed enzymes. ( 26927246 )
Postpartum Vaginal Stenosis Due to Chemical Vaginitis. ( 27437311 )
Analysis of the Vaginal Microbiome by Next-Generation Sequencing and Evaluation of its Performance as a Clinical Diagnostic Tool in Vaginitis. ( 27374709 )
High-dose nifuratel for simple and mixed aerobic vaginitis: A single-center prospective open-label cohort study. ( 27435791 )
Impact of Health-Promoting Educational Intervention on Lifestyle (Nutrition Behaviors, Physical Activity and Mental Health) Related to Vaginal Health Among Reproductive-Aged Women With Vaginitis. ( 28184325 )
Bacterial vaginosis, aerobic vaginitis, vaginal inflammation and major Pap smear abnormalities. ( 26810061 )
A Murine Model of Candida glabrata Vaginitis Shows No Evidence of an Inflammatory Immunopathogenic Response. ( 26807975 )
How to diagnose and treat aerobic and desquamative inflammatory vaginitis. ( 27272705 )
Effects of low dose estrogen therapy on the vaginal microbiomes of women with atrophic vaginitis. ( 27103314 )
Inhalant allergy compounding the chronic vaginitis syndrome: characterization of sensitization patterns, comorbidities and responses to sublingual immunotherapy. ( 27040422 )
Diagnosis of aerobic vaginitis by quantitative real-time PCR. ( 26781259 )

Variations for Vaginitis

Expression for Vaginitis

Search GEO for disease gene expression data for Vaginitis.

Pathways for Vaginitis

Pathways related to Vaginitis according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
Show member pathways
2 12.63 AR CXCL8 ESR1 ESR2 IL6
Show member pathways
Show member pathways
11.96 AR EZR IL6
5 11.87 CXCL8 IL1B IL6
6 11.84 CXCL8 IL1B IL6
7 11.8 CXCL8 IL1B IL6
8 11.76 CXCL8 IL1B IL6
9 11.74 CXCL8 IL1B IL6
10 11.73 AR ESR1 ESR2
Show member pathways
11.7 AR ESR1 ESR2
12 11.69 CXCL8 IL1B IL6
13 11.65 CXCL8 IL1B IL6
14 11.58 CXCL8 IL1B IL6
15 11.47 CXCL8 IL1B IL6
Show member pathways
Show member pathways
11.45 CXCL8 IL1B IL6
18 11.35 CXCL8 IL1B IL6
19 11.23 CXCL8 IL1B IL6
20 11.23 AR CXCL8 ESR2 IL1B IL6
21 11.19 CXCL8 IL1B IL6
22 10.99 ESR1 ESR2
23 10.99 AR IL1B IL6
24 10.94 CXCL8 EZR IL1B IL6
25 10.9 CXCL8 IL6
26 9.86 ESR1 ESR2

GO Terms for Vaginitis

Biological processes related to Vaginitis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.78 AR CXCL8 IL1B IL6
2 positive regulation of gene expression GO:0010628 9.76 AR EZR IL1B IL6
3 positive regulation of transcription, DNA-templated GO:0045893 9.65 AR ESR1 ESR2 IL1B IL6
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.61 AR IL1B IL6
5 negative regulation of neurogenesis GO:0050768 9.51 IL1B IL6
6 positive regulation of neutrophil chemotaxis GO:0090023 9.49 CXCL8 IL1B
7 cell-cell signaling GO:0007267 9.46 AR ESR2 IL1B SH2D1A
8 intracellular estrogen receptor signaling pathway GO:0030520 9.4 ESR1 ESR2
9 mammary gland alveolus development GO:0060749 9.37 AR ESR1
10 positive regulation of glial cell proliferation GO:0060252 9.32 IL1B IL6
11 positive regulation of neuroinflammatory response GO:0150078 8.96 IL1B IL6
12 positive regulation of DNA-binding transcription factor activity GO:0051091 8.92 ESR1 ESR2 IL1B IL6

Molecular functions related to Vaginitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase binding GO:0051117 9.58 AR ESR1 EZR
2 steroid hormone receptor activity GO:0003707 9.5 AR ESR1 ESR2
3 estrogen receptor activity GO:0030284 9.37 ESR1 ESR2
4 nuclear receptor activity GO:0004879 9.33 AR ESR1 ESR2
5 estrogen response element binding GO:0034056 9.26 ESR1 ESR2
6 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 8.96 ESR1 ESR2
7 steroid binding GO:0005496 8.8 AR ESR1 ESR2
8 protein binding GO:0005515 10.25 ABCB1 AR CXCL8 DEFB4A DLAT ESR1

Sources for Vaginitis

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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