MCID: VGN023
MIFTS: 56

Vaginitis

Categories: Infectious diseases, Reproductive diseases

Aliases & Classifications for Vaginitis

MalaCards integrated aliases for Vaginitis:

Name: Vaginitis 12 42 44 15 71
Infective Vaginitis 71

Classifications:



External Ids:

Disease Ontology 12 DOID:2170
ICD9CM 34 616.1
MeSH 44 D014627
NCIt 50 C26911
SNOMED-CT 67 198212006 393596009
UMLS 71 C0042267 C0042268 C0404521

Summaries for Vaginitis

MedlinePlus : 42 What is vaginitis? Vaginitis, also called vulvovaginitis, is an inflammation or infection of the vagina. It can also affect the vulva, which is the external part of a woman's genitals. Vaginitis can cause itching, pain, discharge, and odor. Vaginitis is common, especially in women in their reproductive years. It usually happens when there is a change in the balance of bacteria or yeast that are normally found in your vagina. There are different types of vaginitis, and they have different causes, symptoms, and treatments. What causes vaginitis? Bacterial vaginosis (BV) is the most common vaginal infection in women ages 15-44. It happens when there is an imbalance between the "good" and "harmful" bacteria that are normally found in a woman's vagina. Many things can change the balance of bacteria, including Taking antibiotics Douching Using an intrauterine device (IUD) Having unprotected sex with a new partner Having many sexual partners Yeast infections (candidiasis) happen when too much candida grows in the vagina. Candida is the scientific name for yeast. It is a fungus that lives almost everywhere, including in your body. You may have too much growing in the vagina because of Antibiotics Pregnancy Diabetes, especially if it is not well-controlled Corticosteroid medicines Trichomoniasis can also cause vaginitis. Trichomoniasis is a common sexually transmitted disease. It is caused by a parasite. You can also have vaginitis if you are allergic or sensitive to certain products that you use. Examples include vaginal sprays, douches, spermicides, soaps, detergents, or fabric softeners. They can cause burning, itching, and discharge. Hormonal changes can also cause vaginal irritation. Examples are when you are pregnant or breastfeeding, or when you have gone through menopause. Sometimes you can have more than one cause of vaginitis at the same time. What are the symptoms of vaginitis? The symptoms of vaginitis depend on which type you have. With BV, you may not have symptoms. You could have a thin white or gray vaginal discharge. There may be an odor, such as a strong fish-like odor, especially after sex. Yeast infections produce a thick, white discharge from the vagina that can look like cottage cheese. The discharge can be watery and often has no smell. Yeast infections usually cause the vagina and vulva to become itchy and red. You may not have symptoms when you have trichomoniasis. If you do have them, they include itching, burning, and soreness of the vagina and vulva. You may have burning during urination. You could also have gray-green discharge, which may smell bad. How is the cause of vaginitis diagnosed? To find out the cause of your symptoms, your health care provider may Ask you about your medical history Do a pelvic exam Look for vaginal discharge, noting its color, qualities, and any odor Study a sample of your vaginal fluid under a microscope In some cases, you may need more tests. What are the treatments for vaginitis? The treatment depends on which type of vaginitis you have. BV is treatable with antibiotics. You may get pills to swallow, or cream or gel that you put in your vagina. During treatment, you should use a condom during sex or not have sex at all. Yeast infections are usually treated with a cream or with medicine that you put inside your vagina. You can buy over-the-counter treatments for yeast infections, but you need to be sure that you do have a yeast infection and not another type of vaginitis. See your health care provider if this is the first time you have had symptoms. Even if you have had yeast infections before, it is a good idea to call your health care provider before using an over-the-counter treatment. The treatment for trichomoniasis is usually a single-dose antibiotic. Both you and your partner(s) should be treated, to prevent spreading the infection to others and to keep from getting it again. If your vaginitis is due to an allergy or sensitivity to a product, you need to figure out which product is causing the problem. It could be a product that you started using recently. Once you figure it out, you should stop using the product. If the cause of your vaginitis is a hormonal change, your health care provider may give you estrogen cream to help with your symptoms. Can vaginitis cause other health problems? It is important to treat BV and trichomoniasis, because having either of them can increase your risk for getting HIV or another sexually transmitted disease. If you are pregnant, BV or trichomoniasis can increase your risk for preterm labor and preterm birth. Can vaginitis be prevented? To help prevent vaginitis Do not douche or use vaginal sprays Use a condom when having sex Avoid clothes that hold in heat and moisture Wear cotton underwear

MalaCards based summary : Vaginitis, also known as infective vaginitis, is related to postmenopausal atrophic vaginitis and vulvovaginal candidiasis, and has symptoms including leukorrhea, vaginal pruritus and vaginal odor. An important gene associated with Vaginitis is ESR1 (Estrogen Receptor 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Calcium polycarbophil and Apricot have been mentioned in the context of this disorder. Affiliated tissues include cervix, placenta and skin, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and hematopoietic system

Disease Ontology : 12 A vaginal disease that is characterized by inflammation of the vagina.

Wikipedia : 74 Vaginitis, also known as vulvovaginitis, is inflammation of the vagina and vulva. Symptoms may include... more...

Related Diseases for Vaginitis

Diseases related to Vaginitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 748)
# Related Disease Score Top Affiliating Genes
1 postmenopausal atrophic vaginitis 33.0 ESR2 ESR1
2 vulvovaginal candidiasis 31.9 LAP3 DEFB4A CCR6
3 bacterial vaginosis 30.8 TNF LAP3 IL6 IL1B IL1A IL10
4 candidiasis 30.7 TNF SH2D1A IL6 IL1B IL10 DEFB4A
5 urethral syndrome 30.6 TNF SLPI IL6 IL1B EPPIN CXCL8
6 syphilis 30.6 CD4 CCR6 CCR5
7 vaginal cancer 30.4 ESR2 ESR1 CD4
8 chlamydia 30.3 TNF IL6 IL1B IL1A IL10 CXCL8
9 cystitis 30.3 TNF IL6 IL1A CXCL8
10 genital herpes 30.3 IL10 CD4 CCR6
11 vulvar vestibulitis syndrome 30.3 TNF IL1B ESR1
12 cervicitis 30.2 TNF IL6 IL1B IL10 DEFB4A CXCL8
13 vaginal discharge 30.2 TNF SLPI LAP3 IL6 IL1B IL10
14 placenta disease 30.2 TNF IL6 IL1B CXCL8
15 endometritis 30.2 TNF IL6 IL1B ESR1 CXCL8
16 chancroid 30.2 DLAT CD4 CCR6 CCR5
17 salpingitis 30.2 TNF IL6 CD4
18 trichomoniasis 30.1 TNF SLPI LAP3 IL6 IL1B IL10
19 oral candidiasis 30.1 SLPI SH2D1A IL1A DEFB4A CXCL8 CD4
20 cowpox 30.0 IL6 CXCL8 CD4
21 streptococcal toxic-shock syndrome 30.0 TNF IL6 CXCL8
22 endometrial hyperplasia 30.0 ESR2 ESR1 AR
23 haemophilus influenzae 30.0 TNF CXCL8
24 pyoderma gangrenosum 29.9 TNF CXCL8 CCR6
25 erythema multiforme 29.9 TNF IL6 CXCL8
26 cellulitis 29.9 TNF IL6 DEFB4A CD4 CCR6
27 lichen planus 29.9 TNF IL6 IL1B IL10 DEFB4A CXCL8
28 crohn's colitis 29.8 TNF IL1B CXCL8 CCR6
29 pyoderma 29.8 TNF IL1B CXCL8 CCR6
30 toxic shock syndrome 29.8 TNF IL6 IL1B IL10 CXCL8
31 mucositis 29.8 IL1B IL10 ABCB1
32 peritonitis 29.8 TNF IL6 IL1B IL10 CXCL8
33 gastroesophageal reflux 29.7 TNF IL6 IL1B CXCL8
34 amebiasis 29.7 TNF IL1B IL10 CXCL8 CD4
35 funisitis 29.7 TNF IL6 IL1B IL10 CXCL8
36 arteries, anomalies of 29.7 TNF IL6 IL1B CCR6
37 conjunctivitis 29.7 TNF IL6 IL10 CXCL8
38 pharyngitis 29.6 TNF IL6 IL1B CXCL8 CD4
39 rhinitis 29.6 TNF IL6 IL10 CXCL8
40 cholera 29.6 TNF IL6 IL1B IL10
41 chorioamnionitis 29.6 TNF SLPI IL6 IL1B IL1A IL10
42 urethritis 29.5 TNF IL6 IL1B IL10 EPPIN DEFB4A
43 acute cystitis 29.5 TNF IL6 IL1B IL10 CXCL8 CD4
44 meningoencephalitis 29.5 TNF IL6 IL10 CD4 CCR6
45 liver cirrhosis 29.5 TNF SLPI IL6 IL1B IL10
46 toxoplasmosis 29.4 TNF IL6 IL1B IL10 CCR5
47 vaginal disease 29.3 TNF SLPI LAP3 IL6 IL1B IL1A
48 acne 29.3 TNF IL6 IL1B IL1A DEFB4A CXCL8
49 fungal infectious disease 29.3 TNF IL6 IL1B IL10 DEFB4A CXCL8
50 stomatitis 29.3 TNF IL6 IL1B IL10 CXCL8 CD4

Graphical network of the top 20 diseases related to Vaginitis:



Diseases related to Vaginitis

Symptoms & Phenotypes for Vaginitis

UMLS symptoms related to Vaginitis:


leukorrhea, vaginal pruritus, vaginal odor, vaginal discomfort, vaginal pain or burning

GenomeRNAi Phenotypes related to Vaginitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 8.92 CXCL8 ESR1 ESR2 TNF

MGI Mouse Phenotypes related to Vaginitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.21 ABCB1 AR CCR5 CCR6 CD4 ESR1
2 homeostasis/metabolism MP:0005376 10.17 ABCB1 AR CCR5 CCR6 CD4 ESR1
3 immune system MP:0005387 10.13 ABCB1 AR CCR5 CCR6 CD4 ESR1
4 digestive/alimentary MP:0005381 10.06 ABCB1 AR CCR5 CD4 ESR1 ESR2
5 integument MP:0010771 9.81 AR CD4 ESR1 ESR2 IL10 IL1A
6 liver/biliary system MP:0005370 9.56 ABCB1 AR CCR5 ESR1 ESR2 IL10
7 neoplasm MP:0002006 9.28 AR CCR5 ESR1 ESR2 IL10 IL1A

Drugs & Therapeutics for Vaginitis

Drugs for Vaginitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 528)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Calcium polycarbophil Approved Phase 4 126040-58-2
2 Apricot Approved Phase 4
3
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
4
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
5
Heparin Approved, Investigational Phase 4 9005-49-6 772 9812414
6
Dalteparin Approved Phase 4 9005-49-6
7
Tinzaparin Approved Phase 4 9041-08-1, 9005-49-6 25244225
8
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
9
Fesoterodine Approved Phase 4 286930-03-8, 286930-02-7 6918558
10
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
11
silver nitrate Approved, Investigational Phase 4 7761-88-8
12
Fluconazole Approved, Investigational Phase 4 86386-73-4 3365
13
Tinidazole Approved, Investigational Phase 4 19387-91-8 5479
14
Sodium citrate Approved, Investigational Phase 4 68-04-2
15
Glycerol Approved, Investigational Phase 4 56-81-5 753
16
Misoprostol Approved Phase 4 59122-46-2 5282381
17
Silicon Approved, Investigational Phase 4 7440-21-3 4082203
18
Isosorbide Dinitrate Approved, Investigational Phase 4 87-33-2 6883
19
AT-101 Approved, Investigational Phase 4 90141-22-3, 652-67-5 12597
20
Nitric Oxide Approved Phase 4 10102-43-9 145068
21
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
22
Leuprolide Approved, Investigational Phase 4 53714-56-0 3911 657181
23
Nystatin Approved, Vet_approved Phase 4 1400-61-9 11953884
24
Terconazole Approved Phase 4 67915-31-5 441383
25
Neomycin Approved, Vet_approved Phase 4 1404-04-2 8378
26
Azithromycin Approved Phase 4 83905-01-5 55185 447043
27
Tibolone Approved, Investigational Phase 4 5630-53-5
28
Dequalinium Approved, Investigational Phase 4 6707-58-0
29
Tamoxifen Approved Phase 4 10540-29-1 2733526
30
Mifepristone Approved, Investigational Phase 4 84371-65-3 55245
31
Opium Approved, Illicit Phase 4 8008-60-4
32
Belladonna Approved, Experimental Phase 4
33
Scopolamine Approved, Investigational Phase 4 51-34-3, 6533-68-2 5184
34
Lactitol Approved, Investigational Phase 4 585-86-4 157355
35
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
36
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
37
Ganirelix Approved Phase 4 124904-93-4, 123246-29-7 25081094
38
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
39
Metronidazole Approved Phase 4 443-48-1 4173
40
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
41
Letrozole Approved, Investigational Phase 4 112809-51-5 3902
42
Copper Approved, Investigational Phase 4 7440-50-8 27099
43
Tranexamic Acid Approved Phase 4 1197-18-8 5526
44
Isoniazid Approved, Investigational Phase 4 54-85-3 3767
45
Carbetocin Approved, Investigational Phase 4 37025-55-1 71715 16681432
46
Methenamine Approved, Vet_approved Phase 4 100-97-0 4101
47
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
48
Dinoprostone Approved Phase 4 363-24-6 5280360
49
Iodine Approved, Investigational Phase 4 7553-56-2 807
50
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613

Interventional clinical trials:

(show top 50) (show all 1969)
# Name Status NCT ID Phase Drugs
1 The Effects of Vaginal Estrogen and a Nonhormonal Alternative on the Vaginal and Urinary Microbiome in Women With Genitourinary Syndrome of Menopause: A Randomized Controlled Trial Unknown status NCT02869165 Phase 4 Premarin vaginal cream;Apricot kernel oil
2 A Randomized Controlled Trial Study, To Compare Colporrhaphy Versus NAZCA TC™ ,Macroporous Polypropylene Mesh, In Surgical Treatment To Greater Anterior Vaginal Prolapse . Unknown status NCT00676325 Phase 4
3 Preoperative Vaginal Cleansing With Povidone Iodine and the Risk of Post Cesarean Endometritis Unknown status NCT02693483 Phase 4 10% povidone iodine
4 A Prospective Randomized Multicentre Study to Compare Crinone 8% Once Daily Versus Other Vaginal Progesterone. Unknown status NCT00708539 Phase 4 progesterone;Progesterone
5 The Efficacy and Safety Study of Honghe Fujie Lotion for the Treatment of Bacterial Vaginosis Unknown status NCT03446443 Phase 4 Honghe Fujie lotion;Metronidazole Suppositories
6 Luteal Phase Support With Progesterone vs Estrogen and Progesterone on Pregnancy Rates in Ovarian Stimulation and Intrauterine Insemination Cycles: a Prospective Randomized Study Unknown status NCT01237535 Phase 4 Luteal support with progesterone only;Luteal support with estrogen + progesterone
7 Obstetrical Gel and Its Impact in Shortening the Duration of Labor in Women Undergoing a Vaginal Birth After Cesarean (VBAC):a Randomized Controlled Trial Unknown status NCT03751553 Phase 4 obsteric gel(k-Y jelly)
8 The Effect of Lidocaine - Prilocaine Cream (EMLA) Versus Mepivacaine Infiltration on Pain Relief During And After Mediolateral Episiotomies: A Randomized Clinical Trial Unknown status NCT03264586 Phase 4 Lidocaine-prilocaine cream;mepivacaine infiltration group
9 Comparative Study Between ICSI Results in Transvaginal Ultrasound Guided Embryo Transfer and Transabdominal Ultrasound Guided Embryo Transfer Unknown status NCT03683043 Phase 4 Long GnRH agonist protocol
10 A Double-blind,Randomized,Parallel,Placebo-controlled Study of Probiotics Capsule as Supplemental Therapy for Group B Streptococci Infection and Vaginitis During Pregnancy Unknown status NCT01779193 Phase 4
11 The Effects of the Etonogestrel 0.12mg/Ethinyl Estradiol 0.015mg Vaginal Ring (NuvaRing®) on Vaginal Innate and Inflammatory Biomarkers Unknown status NCT01448291 Phase 4 Etonogestrel /Ethinyl Estradiol Contraceptive Vaginal Ring
12 Prospective Randomized Clinical Trial Comparing the Effect of Vaginal Misoprostol Synchronously With Supracervical Balloon Versus Vaginal Misoprostol Alone for Induction of Labor Unknown status NCT02762942 Phase 4 Misoprostol
13 Effects on Vaginal Health and Quality of Life in Postmenopausal Women Using Ultra Low Topic Estriol Before Vaginal Surgery for Pelvic Statics Disorders Unknown status NCT02906111 Phase 4 estriol
14 Efficacy Comparison of Two Vaginal Solutions for Preoperative Use in Candidate Women for Vaginal Surgeries Unknown status NCT03014778 Phase 4 The Chlorhexidine gluconate 0.05%;10% Povidone iodine
15 Comparison Between Two Strategies of Induction in Case of Unfavourable Cervix After 12 Hours of Premature Rupture of Membranes (PROM) at Term: Cook Cervical Ripening + Oxytocine From 6 Hours Versus Dinoprostone Vaginal Insert Unknown status NCT03310333 Phase 4 Propess® (dinoprostone)
16 Ph IV , Longitudinal, Prospective, Open Label, Non-comparative, to Evaluate the Efficacy, Safety and Tolerability of a Non-hormonal Intravaginal Gel in Postmenopausal Women With Symptoms of Vaginal Dryness. Unknown status NCT02571127 Phase 4 Hidra1
17 Evaluation de l'intérêt de l'électrostimulation Intra-vaginale à Domicile Par Rapport à Une Prise en Charge Habituelle Dans la Prise en Charge de Patientes Incontinentes Ayant bénéficié d'Une rééducation périnéale Unknown status NCT02029027 Phase 4
18 Studying the Role of N-Acetyl Cysteine Either Alone or in Combination With Metronidazole in Treatment of Bacterial Vaginosis Unknown status NCT01841411 Phase 4 N-Acetyl cysteine;Metronidazole + N-Acetyl cysteine;metronidazole
19 The Effect of Adding Vaginal Evening Primrose Oil to Misoprostol During Induction of Second-trimester Missed Miscarriage; a Randomized Controlled Trial Unknown status NCT03584698 Phase 4 Misoprostol 100Mcg Tab;Evening Primrose Oil 1000 MG
20 Randomised Control Trial of Probiotics Versus Placebo as Adjuvant to Oral Clindamycin Treatment for Bacterial Vaginosis During Pregnancy Unknown status NCT01558388 Phase 4 Lactobacillus acidophilus;Placebo
21 Vaginal Misoprostol Versus Bilateral Uterine Artery Ligation in Decreasing Blood Loss in Trans-abdominal Myomectomy , a Randomized Control Trail Unknown status NCT02643186 Phase 4 preoperative vaginal misoprostol
22 Study the Effect of Intravenous Hyoscine Butylbromide Injection on the Duration and Progress of First Stage Labour in High Risk Women Unknown status NCT03055390 Phase 4 hyoscine butylbromide;placebo
23 Evaluation of Perceived Effectiveness to Evaluate Viscosity of a Vaginal Moisturizer in Menopaused Women Unknown status NCT03782961 Phase 4
24 Phase IV Pilot, Longitudinal, Prospective, Double-blind, Comparative to Assess the Perception of Efficacy, Safety and Tolerability of Three Non-hormonal Intravaginal Gels and Hormone Cream in Postmenopausal Women Unknown status NCT02987647 Phase 4
25 Prevención de Parto Prematuro en Gemelares: Ensayo Aleatorio Con Progesterona Vaginal. Unknown status NCT01927029 Phase 4 Progesterone;Placebo
26 Efficacy of Induction of Labor on Term Using a Double Balloon Catheter Compared to Dinoprostone Vaginal-insert - a Multicenter Randomized Controlled Trial Unknown status NCT01720394 Phase 4 Dinoprostone
27 Comparison Between Natural Progesterone and Vaginal Pessary for the Prevention of Spontaneous Preterm Birth in Pregnant Women With a Uterine Cervix Measuring 25 mm or Less in Length Unknown status NCT02511574 Phase 4 natural progesterone
28 Vaginal Progesterone Versus Cervical Cerclage for Pregnant Women With Sonographic Short Cervix and History of Preterm Labor and/or Midtrimester Miscarriage Unknown status NCT02673359 Phase 4 Progesterone
29 Randomized, Open-label, Multicenter Study of Azithromycin Compared With Doxycycline for Treating Anorectal Chlamydia Trachomatis Infection Concomitant to a Vaginal Infection Unknown status NCT03532464 Phase 4 azithromycin;doxycycline
30 0.05 vs. 0.1 Milligram Spinal Morphine for Reducing Morphine Requirement After Vaginal Hysterectomy With/Without Anterior and Posterior Vaginoplasty Unknown status NCT01080911 Phase 4 Morphine;Morphine
31 The Comparison of 0.05 vs. 0.1 Milligram Spinal Morphine for Reducing Morphine Requirement After Vaginal Hysterectomy With/Without Anterior and Posterior Vaginoplasty Unknown status NCT01079754 Phase 4 Spinal morphine 0.05 mg;Spinal morphine 0.1 mg
32 Open-Label Vulvoscopy Photography Study of Changes in Vulva, Vestibule, Urethral Meatus and Vagina 20 Weeks Post Daily Administration of 6.5 Mg Vaginal Prasterone in Menopausal Women With Moderate to Severe Dyspareunia Unknown status NCT03568604 Phase 4 Prasterone
33 A Combined Treatment Program for the Symptoms of Urinary Urgency and Frequency With Toviaz and Premarin Vaginal Cream Unknown status NCT01613170 Phase 4 Toviaz;Premarin;Placebo cream
34 The Effects of Contraceptive Pill and Hormonal Vaginal Ring on Hormonal, Inflammatory and Metabolic Parameters in Women of Reproductive Age With Polycystic Ovary Syndrome (PCOS). Unknown status NCT01588873 Phase 4 oc:E-E-desogestrel/vaginal ring:E-E -ethonogestrel
35 Trans-vaginal Aspiration With or Without Injection of Surgicel for Treatment of Small Ovarian Endometrioma Before ICSI Cycles. A Randomized Controlled Trial Unknown status NCT03784404 Phase 4 Intracytoplasmic sperm injection
36 Efficacy and Safety of Hourly Titrated Misoprostol Versus Vaginal Dinoprostone and Misoprostol for Cervical Ripening and Labor Induction: Randomized Clinical Trial Unknown status NCT02902653 Phase 4 Oral misoprostol;Vaginal misoprostol;Vaginal dinoprostone
37 Oral Tramadol Versus Oral Celecoxib for Post-perineal Repair Analgesia After Spontaneous Vaginal Birth in Obese Women: A Randomised Controlled Trial Unknown status NCT03694873 Phase 4 Tramadol Hydrochloride;Celecoxib 200mg
38 A Randomized Controlled Trial of Vaginal Estrogen to Treat Asymptomatic Microscopic Hematuria Unknown status NCT03033160 Phase 4 Estradiol Ring
39 Randomized Pilot Study on the Treatment of Mixed Urinary Incontinence: Pharmacological Treatment (Tolterodine SR) vs Surgery With Tension Free Vaginal Tape Unknown status NCT00523068 Phase 4 Tolterodine
40 Vaginal Misodel® in Comparison With Orally Administrated Misoprostol (Cytotec®) at Induction of Labour Unknown status NCT02918110 Phase 4 Misoprostol
41 Phase 4 Study Comparison of Two Combined Oral Contraceptive Regimens and an Intravaginal Hormonal Ring Against Placebo for Management of Bleeding Problems in Women Using Implanon, the Sub-dermal Contraceptive Implant Unknown status NCT01384331 Phase 4 Marvelon
42 Sacrospinous Colpopexy Versus High Uterosacral Colpopexy in the Treatment of Genital Prolapse Grade III/IV in Women With Uterus Unknown status NCT01347021 Phase 4
43 Comparison Between Natural and Artificial Cycle in Recipient Oocyte Patients Unknown status NCT01353846 Phase 4 Agonist GnRH; estradiol Valerate; progesterone
44 Low Dose Estriol With Lactobacilli (Gynoflor) Treatment for Preventing Recurrent Urinary Tract Infection in Postmenopausal Women: A Randomized, Open, Parallel-Group Study Unknown status NCT00900653 Phase 4 Gynoflor E (low dose estriol with lactobacillus)
45 Comparison of Clinical Pregnancy Rates Between Two Protocols, With or Without Low Molecular Weight Heparin Administration Before Frozen Embryo Transfer in Hormonal Replacement Cycles: a Prospective Randomized Controlled Trial Unknown status NCT03120715 Phase 4 estrogen;Low Molecular Weight Heparin;hCG;progesterone
46 Role of Progesterone in Hypoactive Sexual Desire Disorder in Menopausal Women Unknown status NCT02968342 Phase 4
47 The Treatment of Bartholin´s Cyst or Abscess With Silver Nitrate Unknown status NCT00786461 Phase 4
48 AFTER: Application for the Etonogestrel/Ethinyl Estradiol Ring--potential for Emergency Contraception Unknown status NCT03120728 Phase 4 Etonogestrel/ethinyl estradiol contraceptive vaginal ring
49 Misoprostol With And Without Transcervical Balloon Catheter In Second Trimester Termination Of Pregnancy: A Randomized Controlled Trial Unknown status NCT03106389 Phase 4 Misoprostol
50 Role of Serum Progesterone and Doppler Ultrasound in Prediction of Pregnancy Outcome in Women With Recurrent Unexplained Abortion Unknown status NCT03267771 Phase 4 Progesterone Suppositories Vaginal;Dydrogesterone Oral Tablet

Search NIH Clinical Center for Vaginitis

Inferred drug relations via UMLS 71 / NDF-RT 51 :


sulfathiazole

Cochrane evidence based reviews: vaginitis

Genetic Tests for Vaginitis

Anatomical Context for Vaginitis

MalaCards organs/tissues related to Vaginitis:

40
Cervix, Placenta, Skin, Uterus, Breast, Bone, Ovary

Publications for Vaginitis

Articles related to Vaginitis:

(show top 50) (show all 3558)
# Title Authors PMID Year
1
Improving management of the genitourinary syndrome of menopause: evaluation of a health system-based, cluster-randomized intervention. 42
32693097 2021
2
Oral Ibrexafungerp: an investigational agent for the treatment of vulvovaginal candidiasis. 42
32746636 2020
3
Screening for Bacterial Vaginosis in Pregnant Persons to Prevent Preterm Delivery: Recommendation Statement. 42
32667170 2020
4
Aloe Vera; A new treatment for atrophic vaginitis, A randomized double-blinded controlled trial. 61
33383112 2021
5
Fractional Co2 Laser Treatment of the Vulva and Vagina and the Effect of Postmenopausal Duration on Efficacy. 61
32329093 2021
6
Guideline: Vulvovaginal candidosis (AWMF 015/072, level S2k). 61
33529414 2021
7
Clinical validation of a new molecular test (Seegene® AllplexTM Vaginitis) for the diagnosis of vaginitis: a cross sectional study. 61
33540484 2021
8
Efficacy and safety of three plant extracts based formulations of vagitories in the treatment of vaginitis: a randomized controlled trial. 61
33269580 2021
9
Hand-Held Zoom Micro-Imaging System Based on Microfluidic Chip for Point-of-Care Testing (POCT) of Vaginal Inflammation. 61
33552751 2021
10
[The role of herpesviruses in development of diseases of the urogenital tract and infertility in women]. 61
33533228 2021
11
Hyaluronic Acid in Postmenopause Vaginal Atrophy: A Systematic Review. 61
33293236 2021
12
Vaginal Dysbiosis and Partial Bacterial Vaginosis: The Interpretation of the "Grey Zones" of Clinical Practice. 61
33525708 2021
13
Genitourinary Syndrome of Menopause: Current Treatment Options in Breast Cancer Survivors - Systematic Review. 61
33308636 2021
14
Gynecological Disorders in Patients with Non-celiac Wheat Sensitivity. 61
32146601 2021
15
Sequence of Pelvic Examination Does Not Affect Patients With Baseline Vulvovaginal Syndromes: A Randomized Clinical Trial. 61
32332423 2021
16
A Qualitative Investigation of the Acceptability and Feasibility of a Urinary Tract Infection Patient Information Leaflet for Older Adults and Their Carers. 61
33467185 2021
17
Aerobic Vaginitis-Underestimated Risk Factor for Cervical Intraepithelial Neoplasia. 61
33435407 2021
18
Comparison of viromes in vaginal secretion from pregnant women with and without vaginitis. 61
33407663 2021
19
[Consensus on the diagnosis and treatment of mixed vaginitis (2021 edition)]. 61
33486923 2021
20
[Consensus on diagnosis and treatment of aerobic vaginitis (2021 edition)]. 61
33486922 2021
21
Nucleic Acid Amplification Testing Compared With Cultures, Gram Stain, and Microscopy in the Diagnosis of Vaginitis. 61
33347046 2021
22
Predictive value of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients with Vaginitis. 61
33437286 2021
23
The Neutral Vaginal pH in Mice That Is Typical of Most Mammalian Species Should Not Deter Research Using Experimental Murine Models of Candida Vaginitis. 61
33199352 2021
24
Prevalence and Antimicrobial Susceptibility Profiles of Microorganisms Associated with Lower Reproductive Tract Infections in Women from Southern Poland-Retrospective Laboratory-Based Study. 61
33466345 2021
25
Exogenous Reproductive Hormones nor Candida albicans Colonization Alter the Near Neutral Mouse Vaginal pH. 61
33106292 2021
26
[Relations of human papillomavirus infection, vaginal micro-environmental disorder with cervical lesion]. 61
33378829 2020
27
The alteration and potential relationship of vaginal microbiota and chemokines for unexplained recurrent spontaneous abortion. 61
33371084 2020
28
Observation and Nursing of the Curative Effect of Ag/TiO₂ Nanomaterials on Bacterial Vaginosis and Trichomonal Vaginitis. 61
32711609 2020
29
The apparition macrophage and Döderlein bacillus is negatively correlated in class I Papanicolaou smear: A morphological examination. 61
32628346 2020
30
Effect of a novel herbal vaginal suppository containing myrtle and oak gall in the treatment of vaginitis: a randomized clinical trial. 61
32888185 2020
31
Evaluation of the Antimicrobial Activity of an Extract of Lactobacillus casei-Infected Hermetia illucens Larvae Produced Using an Automatic Injection System. 61
33207571 2020
32
A Game Show-Based Curriculum for Teaching Principles of Reproductive Infectious Disease (GBS PRIDE Trial). 61
33140104 2020
33
Human Fungal Infections in Kuwait-Burden and Diagnostic Gaps. 61
33233367 2020
34
Vaginal Rejuvenation: A Retrospective Review of Lasers and Radiofrequency Devices. 61
33165070 2020
35
Occurrence of mecA and blaZ genes in methicillin-resistant Staphylococcus aureus associated with vaginitis among pregnant women in Ado-Ekiti, Nigeria. 61
33133613 2020
36
Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health. 61
33160356 2020
37
Female warfighters' perceptions of urogenital health in operational settings. 61
33177334 2020
38
Eradication of Cokeromyces recurvatus in a pregnant patient: A case report. 61
32983910 2020
39
Association of the vaginal microbiota with pregnancy outcomes in Chinese women after cervical cerclage. 61
32855065 2020
40
Physician Awareness and Adherence to Clinical Practice Guidelines in the Diagnosis of Vaginitis Patients: A Retrospective Chart Review. 61
32985960 2020
41
Vaginal microbiota evaluation and prevalence of key pathogens in ecuadorian women: an epidemiologic analysis. 61
33110095 2020
42
Epidemiology, risk factors and antimicrobial profile of Vulvovaginal Candidiasis (VVC): A study among women in the central region of Saudi Arabia. 61
33153879 2020
43
Cost-effectiveness of nucleic acid amplification testing to guide treatment for vaginitis: a decision-modeling analysis. 61
32683205 2020
44
Aerobic vaginitis - An underdiagnosed cause of vaginal discharge - Narrative review. 61
32842907 2020
45
Improving the Diagnosis of Vulvovaginitis: Perspectives to Align Practice, Guidelines, and Awareness. 61
32997581 2020
46
Treating vaginitis with probiotics in non-pregnant females: A systematic review and meta-analysis. 61
32855726 2020
47
The Dwindling Microbiota of Aerobic Vaginitis, an Inflammatory State Enriched in Pathobionts with Limited TLR Stimulation. 61
33126716 2020
48
In vitro anti-inflammatory potential of phloretin microemulsion as a new formulation for prospective treatment of vaginitis. 61
32363977 2020
49
The association between vaginal microbiota and female infertility: a systematic review and meta-analysis. 61
32638096 2020
50
Genome-Wide Mutagenesis Identifies Factors Involved in Enterococcus faecalis Vaginal Adherence and Persistence. 61
32778611 2020

Variations for Vaginitis

Expression for Vaginitis

Search GEO for disease gene expression data for Vaginitis.

Pathways for Vaginitis

Pathways related to Vaginitis according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.08 TNF SLPI SH2D1A IL6 IL1B IL1A
2
Show member pathways
13.87 TNF IL6 IL1B IL1A IL10 ESR2
3
Show member pathways
13.73 TNF IL6 IL1B IL1A IL10 CXCL8
4
Show member pathways
13.41 TNF IL6 IL1B IL1A IL10 CXCL8
5
Show member pathways
13.38 TNF IL6 IL1B IL1A IL10 CXCL8
6
Show member pathways
13.32 TNF IL6 IL1B IL1A IL10 CXCL8
7
Show member pathways
13.09 TNF IL6 IL1B IL10 CXCL8 CCL4L1
8
Show member pathways
13.01 TNF IL6 IL1B CXCL8 CD4 CCR5
9
Show member pathways
12.94 CXCL8 CD4 CCR6 CCR5 CCL4L1 AR
10
Show member pathways
12.87 TNF IL6 IL1B IL1A IL10 CXCL8
11
Show member pathways
12.84 TNF IL6 IL1B IL1A CXCL8
12
Show member pathways
12.75 TNF IL6 IL1B IL1A CXCL8
13
Show member pathways
12.71 TNF IL1B IL1A CD4 CCR5
14
Show member pathways
12.67 TNF IL6 IL1B IL1A IL10 CD4
15
Show member pathways
12.66 TNF IL6 IL1B IL1A IL10 CD4
16
Show member pathways
12.64 TNF IL6 IL1B IL10 CD4
17
Show member pathways
12.41 TNF IL6 IL1B DEFB4A CXCL8
18
Show member pathways
12.38 TNF IL6 IL1B IL1A CXCL8
19
Show member pathways
12.36 EPPIN DEFB4A CD4 CCR6
20
Show member pathways
12.34 TNF IL1B IL1A IL10 CCR5
21
Show member pathways
12.33 TNF IL6 IL1B IL1A IL10 CXCL8
22 12.32 TNF IL6 IL1B DEFB4A CXCL8
23 12.31 TNF IL6 IL1B IL1A IL10
24
Show member pathways
12.3 TNF IL6 IL1A CXCL8
25
Show member pathways
12.25 TNF IL6 IL1B IL10
26
Show member pathways
12.25 TNF IL6 IL1B DEFB4A CXCL8
27
Show member pathways
12.25 TNF IL6 IL10 CXCL8 CCR6 CCR5
28 12.1 TNF IL6 IL1B IL1A CXCL8
29 12.09 TNF IL6 IL1B IL10 CXCL8 CD4
30 12.06 TNF IL6 IL10 CD4
31
Show member pathways
12.05 IL1B CD4 CCR5 CCL4L1
32 12.01 IL6 IL1B IL1A CXCL8
33 12.01 TNF IL6 IL1B IL10 CXCL8
34 12 TNF IL1B CXCL8 CCL4L1
35 12 TNF IL6 IL1B IL1A CXCL8
36 11.98 TNF IL6 IL1B IL1A CD4
37 11.97 TNF IL6 IL1B IL1A IL10 CXCL8
38 11.97 TNF IL6 IL1B IL1A IL10 ESR2
39 11.95 TNF IL6 IL1B IL1A CXCL8
40 11.87 TNF IL1B IL10 CD4 CCR6
41
Show member pathways
11.83 TNF IL6 IL1B IL10 CD4
42 11.8 TNF IL6 IL1B IL10 CD4
43 11.79 IL10 ESR1 AR
44 11.78 TNF IL6 IL10 CCR6
45 11.74 TNF IL6 IL1B CXCL8
46
Show member pathways
11.71 TNF IL6 IL1B IL1A CXCL8
47 11.68 TNF IL6 IL1B CXCL8
48 11.61 TNF IL6 IL1B IL1A IL10 CXCL8
49 11.57 IL6 IL1B IL1A
50 11.55 TNF IL6 IL1B IL10 CXCL8

GO Terms for Vaginitis

Cellular components related to Vaginitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.43 TNF EPPIN CD4 CCR6 CCR5 ABCB1
2 extracellular space GO:0005615 9.32 TNF SLPI IL6 IL1B IL1A IL10
3 sperm plasma membrane GO:0097524 9.16 EPPIN CCR6

Biological processes related to Vaginitis according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.27 IL6 IL1B IL10 ESR2 ESR1 CXCL8
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.22 TNF IL6 IL1A IL10 ESR2 ESR1
3 positive regulation of gene expression GO:0010628 10.08 TNF IL6 IL1B IL1A CXCL8 AR
4 negative regulation of cell proliferation GO:0008285 10.04 IL6 IL1B IL1A IL10 CXCL8 AR
5 positive regulation of transcription, DNA-templated GO:0045893 10.01 TNF IL6 IL1B IL10 ESR2 ESR1
6 defense response to bacterium GO:0042742 9.99 TNF SLPI IL10 EPPIN DEFB4A
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.96 TNF IL6 IL1B AR
8 cell-cell signaling GO:0007267 9.96 SH2D1A IL1B ESR2 CCR5 AR
9 chemotaxis GO:0006935 9.95 DEFB4A CXCL8 CCR6 CCR5
10 regulation of insulin secretion GO:0050796 9.87 TNF IL6 IL1B
11 inflammatory response GO:0006954 9.87 TNF IL6 IL1B IL1A CXCL8 CCR5
12 response to glucocorticoid GO:0051384 9.86 TNF IL6 IL10
13 positive regulation of T cell proliferation GO:0042102 9.85 IL6 IL1B CD4
14 positive regulation of interleukin-8 production GO:0032757 9.85 TNF IL6 IL1B
15 positive regulation of cytokine production GO:0001819 9.85 TNF IL1A IL10
16 positive regulation of interleukin-6 production GO:0032755 9.85 TNF IL6 IL1B IL1A
17 cellular defense response GO:0006968 9.84 SH2D1A CCR6 CCR5
18 cellular response to estradiol stimulus GO:0071392 9.81 IL10 ESR2 ESR1
19 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.81 TNF IL1B IL1A
20 chemokine-mediated signaling pathway GO:0070098 9.81 CXCL8 CCR6 CCR5 CCL4L1
21 positive regulation of JAK-STAT cascade GO:0046427 9.79 TNF IL6 IL10
22 positive regulation of interleukin-2 production GO:0032743 9.79 IL1B IL1A CD4
23 positive regulation of vascular endothelial growth factor production GO:0010575 9.77 IL6 IL1B IL1A
24 negative regulation of neurogenesis GO:0050768 9.76 TNF IL6 IL1B
25 humoral immune response GO:0006959 9.76 TNF SH2D1A IL6 CCR6
26 positive regulation of DNA-binding transcription factor activity GO:0051091 9.73 TNF IL6 IL1B IL10 ESR2 ESR1
27 intracellular estrogen receptor signaling pathway GO:0030520 9.71 ESR2 ESR1 AR
28 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.7 TNF ESR1
29 response to molecule of bacterial origin GO:0002237 9.7 IL10 CXCL8
30 regulation of establishment of endothelial barrier GO:1903140 9.7 TNF IL1B
31 positive regulation of glial cell proliferation GO:0060252 9.7 TNF IL6 IL1B
32 cellular response to lipopolysaccharide GO:0071222 9.7 TNF IL6 IL1B IL1A IL10 CXCL8
33 negative regulation of lipid storage GO:0010888 9.69 TNF IL6
34 endothelial cell apoptotic process GO:0072577 9.68 TNF IL10
35 fusion of virus membrane with host plasma membrane GO:0019064 9.68 CD4 CCR5
36 negative regulation of cytokine production involved in immune response GO:0002719 9.67 TNF IL10
37 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.67 TNF IL1B IL10
38 positive regulation of fever generation GO:0031622 9.66 TNF IL1B
39 positive regulation of immature T cell proliferation in thymus GO:0033092 9.65 IL1B IL1A
40 positive regulation of neuroinflammatory response GO:0150078 9.65 TNF IL6 IL1B
41 sequestering of triglyceride GO:0030730 9.64 TNF IL1B
42 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.63 TNF IL1B
43 fever generation GO:0001660 9.62 IL1B IL1A
44 intracellular steroid hormone receptor signaling pathway GO:0030518 9.61 ESR2 ESR1 AR
45 cytokine-mediated signaling pathway GO:0019221 9.56 TNF IL6 IL1B IL1A IL10 CXCL8
46 vascular endothelial growth factor production GO:0010573 9.54 TNF IL6 IL1B
47 immune response GO:0006955 9.36 TNF SLPI IL6 IL1B IL1A IL10

Molecular functions related to Vaginitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.16 TNF SLPI SH2D1A LAP3 IL6 IL1B
2 enzyme binding GO:0019899 9.8 SLPI ESR2 ESR1 CD4 AR
3 nuclear receptor activity GO:0004879 9.54 ESR2 ESR1 AR
4 estrogen receptor activity GO:0030284 9.32 ESR2 ESR1
5 estrogen response element binding GO:0034056 9.26 ESR2 ESR1
6 steroid binding GO:0005496 9.13 ESR2 ESR1 AR
7 cytokine activity GO:0005125 9.1 TNF IL6 IL1B IL1A IL10 CXCL8

Sources for Vaginitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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