MCID: VRC001
MIFTS: 49

Varicocele

Categories: Blood diseases, Cardiovascular diseases, Reproductive diseases

Aliases & Classifications for Varicocele

MalaCards integrated aliases for Varicocele:

Name: Varicocele 12 54 6 43 15 71
Scrotal Varices 12 32
Varicoceles 62

Classifications:



External Ids:

Disease Ontology 12 DOID:12337
ICD9CM 34 456.4
MeSH 43 D014646
SNOMED-CT 67 51070004
ICD10 32 I86.1
UMLS 71 C0042341

Summaries for Varicocele

PubMed Health : 62 About varicoceles: Varicoceles are varicose veins in the scrotum. They form in the veins that run along the spermatic cord. Blood from the testicles flows back into the body through those veins. Like varicose veins in the legs, varicoceles form when blood builds up in the veins and they become permanently enlarged.

MalaCards based summary : Varicocele, also known as scrotal varices, is related to varicose veins and infertility, and has symptoms including pain in scrotum An important gene associated with Varicocele is GNRH1 (Gonadotropin Releasing Hormone 1), and among its related pathways/superpathways are Pathways in cancer and Prolactin Signaling Pathway. The drugs Ginseng and Methylene blue have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and prostate, and related phenotypes are endocrine/exocrine gland and neoplasm

Wikipedia : 74 A varicocele is an abnormal enlargement of the pampiniform venous plexus in the scrotum. This plexus of... more...

Related Diseases for Varicocele

Diseases related to Varicocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 245)
# Related Disease Score Top Affiliating Genes
1 varicose veins 33.1 SHBG HIF1A CASP9
2 infertility 32.0 SHBG PRL PLCZ1 GNRH1 ACR
3 testicular disease 31.5 GNRH1 AMH ALB
4 oligospermia 31.4 PRL GSTM1 FAM47C AMH
5 male infertility 31.3 SHBG PLCZ1 GSTM1 GNRH1 CAT AZF1
6 oligoasthenoteratozoospermia 30.9 GSTM1 AMH ACR
7 cryptorchidism, unilateral or bilateral 30.8 SHBG PRL GNRH1 AZF1 AMH
8 gynecomastia 30.8 SHBG PRL GNRH1
9 prostatitis 30.6 PRL CAT CASP3
10 impotence 30.5 SHBG PRL NOS3 NOS2 GNRH1 ALB
11 testicular torsion 30.5 NOS3 CAT CASP3 AMH
12 portal hypertension 30.4 NOS3 NOS2 ALB
13 hypogonadotropic hypogonadism 30.4 SHBG PRL GNRH1 AMH
14 hyperprolactinemia 30.4 SHBG PRL GNRH1
15 sexual disorder 30.4 SHBG PRL NOS3 GNRH1 ALB
16 vascular disease 30.3 NOS3 NOS2 CAT CASP3 ALB
17 anovulation 30.3 SHBG PRL GNRH1 AMH
18 retinal vascular disease 30.1 NOS3 HIF1A CASP3 ALB
19 pelvic varices 29.8 SHBG PRL LDHC GNRH1 CASP3 AMH
20 body mass index quantitative trait locus 11 29.6 SHBG PRL NOS3 HIF1A GSTM1 CAT
21 spermatocele 11.6
22 hydrocele 10.9
23 azoospermia 10.8
24 inhibited female orgasm 10.6 SHBG PRL
25 inguinal hernia 10.6
26 platelet membrane fluidity 10.6 NOS3 NOS2
27 chronic salpingo-oophoritis 10.5 PRL AMH
28 body mass index quantitative trait locus 1 10.5
29 estrogen excess 10.5 SHBG PRL GNRH1
30 cerebral hypoxia 10.5 CASP9 CASP3
31 premenstrual tension 10.5 SHBG GNRH1
32 hypogonadism 10.5
33 postmenopausal atrophic vaginitis 10.5 SHBG AMH
34 hypoactive sexual desire disorder 10.5 SHBG PRL
35 dystrophinopathies 10.5 NOS2 CASP9
36 salpingitis isthmica nodosa 10.5 PRL GNRH1 AMH
37 ovarian benign neoplasm 10.5 PRL GNRH1 AMH
38 ovarian cyst 10.5 PRL GNRH1 AMH
39 heterophyiasis 10.5 CASP3 ALB
40 polyp of corpus uteri 10.5 PRL GNRH1
41 priapism 10.5 NOS3 NOS2 GNRH1
42 pyometritis 10.4 PRL GNRH1
43 amenorrhea 10.4 SHBG PRL GNRH1
44 hyperandrogenism 10.4 SHBG PRL GNRH1
45 immuno-osseous dysplasia 10.4 NOS2 ALB
46 cerebral artery occlusion 10.4 NOS3 NOS2 HIF1A
47 spermatogenic failure 3 10.4
48 meningitis and encephalitis 10.4 CAT ALB
49 steroid inherited metabolic disorder 10.4 SHBG PRL GNRH1 AMH
50 sebaceous gland disease 10.4 SHBG PRL GNRH1 AMH

Comorbidity relations with Varicocele via Phenotypic Disease Network (PDN):


Prostatic Hypertrophy

Graphical network of the top 20 diseases related to Varicocele:



Diseases related to Varicocele

Symptoms & Phenotypes for Varicocele

UMLS symptoms related to Varicocele:


pain in scrotum

MGI Mouse Phenotypes related to Varicocele:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.93 ALB AMH CASP3 CASP9 GNRH1 HIF1A
2 neoplasm MP:0002006 9.5 ALB AMH CAT GNRH1 HIF1A NOS2
3 reproductive system MP:0005389 9.4 ACR AMH CASP3 GNRH1 HSP90AA1 HSPA2

Drugs & Therapeutics for Varicocele

PubMed Health treatment related to Varicocele: 62

Varicoceles do not normally need to be treated. But some experts do suggest treatment for men who have fertility problems and a varicocele , in the hope that it will improve fertility. The treatment involves “shutting down” the affected vein so that the blood flows through healthy, neighboring veins instead. This can be done by blocking the vein using minimally-invasive procedures (embolization) or by performing varicose vein surgery . In embolization, the affected vein is blocked using a catheter to inject either a solution that causes scarring (sclerotherapy), a tissue adhesive, or a detachable balloon or coil. In surgery, the swollen vein and the surrounding smaller veins are either cut or tied.

Drugs for Varicocele (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ginseng Approved, Investigational, Nutraceutical Phase 4 50647-08-0
2
Methylene blue Approved, Investigational Phase 2 61-73-4
3
Menotropins Approved Phase 2 61489-71-2, 9002-68-0 5360545
4 Hormones Phase 2
5 Chorionic Gonadotropin Phase 2
6
Selenium Approved, Investigational, Vet_approved 7782-49-2
7
Acetylcarnitine Approved, Investigational 3040-38-8 7045767
8
Methylcobalamin Approved, Investigational 13422-55-4
9
leucovorin Approved 58-05-9 6006 143
10
Sodium citrate Approved, Investigational 68-04-2
11
Zinc Approved, Investigational 7440-66-6 32051
12
Hydroxocobalamin Approved 13422-51-0 15589840 11953898
13
Papaverine Approved, Investigational 58-74-2, 61-25-6 4680
14
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
15
Sodium Tetradecyl Sulfate Approved, Investigational 1191-50-0, 139-88-8 5248 14492
16
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
17
Citric acid Approved, Nutraceutical, Vet_approved 77-92-9 311
18
Cyanocobalamin Approved, Nutraceutical 68-19-9 44176380
19
Vitamin C Approved, Nutraceutical 50-81-7 5785 54670067
20
Coenzyme Q10 Approved, Investigational, Nutraceutical 303-98-0 5281915
21
Cobalamin Experimental 13408-78-1 6857388
22 Anti-Inflammatory Agents
23 Androgens
24 Estrogens
25 Follicle Stimulating Hormone
26 Vaccines
27 Vitamins
28 Vitamin B Complex
29 Vitamin B 12
30 carnitine
31 Antioxidants
32 Citrate
33 Folate
34 Vitamin B12
35 Vitamin B9
36 Ubiquinone
37 Anti-Infective Agents, Local
38 Anesthetics
39 Anesthetics, Local
40 Analgesics
41 Sclerosing Solutions
42 Hormone Antagonists

Interventional clinical trials:

(show all 43)
# Name Status NCT ID Phase Drugs
1 Role of FSHR Polymorphism p.N680S in the Therapy With FSH in Patients Who Underwent Varicocele Surgery Unknown status NCT02719093 Phase 4 recombinant FSH
2 Comparison of Outcomes of Two Approaches in Microsurgical Varicocelectomy in Chinese Infertile Males: A Prospective Randomized, Controlled Trial Completed NCT01463787 Phase 4
3 Effects of Korean Red Ginseng on Male Infertility Completed NCT02202382 Phase 4 Korean Red Ginseng, Varicocelectomy;Placebo
4 A Prospective, Randomized, Study of Microsurgical Varicocelectomy Versus Observation in the Treatment of Male Partners With a Palpable Varicocele and an Abnormal Semen Analysis Terminated NCT00767338 Phase 3
5 Dye Assisted Lymphatic Sparing Varicocelectomy,Prospective Randomized Study Completed NCT01259258 Phase 2
6 Pharmacodynamics and Safety of Human Recombinant Luteinising Hormone in Hypogonadotropic Hypogonadal Men Not yet recruiting NCT04189133 Phase 2 Lutropin alfa;Human chorionic gonadotropin
7 Comparison Between Laparoscopic Doppler Ultrasound Assisted Laparoscopic Varicocelectomy and Microscopic Subinguinal Varicocelectomy Unknown status NCT02695199
8 Comparison Between Impact of Inguinal and Subinguinal Approaches of Varicocelectomy on Semen Parameters in Patients With Normal Semen Analysis Unknown status NCT03281915
9 Endovasculer Treatement of Male Pelvic Venous Insufficiency Unknown status NCT03341897
10 PrOspective, MultiCenter Study for the Evaluation of PerformanCe of the ArtVentive Medical Group Peripheral EndoLuminal OcclUsion SystemTM in the Treatment of Varicocele or Pelvic Congestion SynDromE - OCCLUDE I Unknown status NCT02033863
11 Outcome of ICSI Using Cryopreserved Testicular Sperm From Infertile Men With Varicocele-associated Azoospermia Unknown status NCT02306499
12 EASYX-1 : A Multicenter Study on Safety and Efficacy of Easyx Liquid Embolization Agent Used in Five Separate Indications Unknown status NCT03477149
13 Evaluation of the Impact of Open or Laparoscopic Preperitoneal Inguinal Hernia Repair on Arterial and Venous Testicular Vascularization by Means of Ecocolordoppler Ultrasound Examination Unknown status NCT03056027
14 Odense Androgen Study – A Population-Based Study of Androgens, Body Composition, and Muscle Function in 20-29 Year-Old Danish Men Unknown status NCT00150163
15 Quality of Life Among Testicular Cancer Survivors Unknown status NCT02304575
16 Beneficial Effects of Microsurgical Varicocelectomy on Semen Parameters in Patients Who Underwent Surgery for Causes Other Than Infertility Completed NCT02006316
17 Increased Testicular Cd2+ & Infertility With Varicocele ( a Varicose Vein in the Scrotum) Completed NCT00044369
18 Analysis on AEFI Surveillance Data for Live Attenuated Varicella Vaccine Completed NCT02983656
19 The Anaesthesiological Approach to Varicocele Correction in Outpatients Setting: an Observational Analysis Completed NCT02401087
20 Selective Retrograde Venography and Sclerotherapy of Internal Spermatic Veins and Associated Venous Bypasses and Retro-Peritoneal Collateral in Patients With Varicocele and Hypertrophy of Prostate Completed NCT00639899
21 Varicocelectomy To Treat Pain, Predictors Of Success : A Prospective Study Completed NCT01395186
22 the Effect of Sub-inguinal Varicocelectomy in Patients Complaining of Orchialgia With Normal Semen Analysis Completed NCT03835143
23 Selective Retrograde Venography and Sclerotherapy of Internal Spermatic Veins and Associated Venous Bypasses and Retro-Peritoneal Collateral in Patients With Bilateral Varicocele and Localized Prostate Cancer Completed NCT00637208
24 Single Incision Transumbilical Laparoscopic Varicocelectomy: Comparison With the Conventional Laparoscopic Approach. Completed NCT02335385
25 Seminal TEX101 as a Predictor of Recovery of Spermatogenesis in Azoospermic Men With Palpable Varicocele Completed NCT04397887
26 Assessing Post-operative Rates of Recurrence, Hydrocele and Testicular Atrophy in Patients Operated With a New Approach of Varicocelectomy Named Combined Mini-incision Microscopic Varicocelectomy (CMMV) Completed NCT02092311
27 Body Mass Index and Age Correlate With Antioxidant Supplementation Effects on Sperm Quality: Post-hoc Analyses From a Double-blind Placebo-controlled Trial Completed NCT04177667
28 Effect of TAP Block for Postoperative Pain Control After Varicocele Operations on Analgesia Quality and Postoperative Analgesic Consumption Completed NCT02983383
29 The Role of Artery-Preserving Varicocelectomy in Subfertile Men With Severe Oligozoospermia; A Randomized Controlled Study Completed NCT03344588
30 The Effect of Myofascial Relaxation Technique on the Treatment of Primary Dysmenorrhea in Psoas Muscle Completed NCT04254510
31 Outcomes of Intra-Cytoplasmic Sperm Injection in Infertile Men With Non-tense Vaginal Hydrocele Completed NCT03532386
32 Animal-assisted Therapy in Pediatric Surgery: Cardiovascular, Neurological and Endocrinological Responses to Stress and Pain in the Immediate Post-operative Period Completed NCT02284100
33 Testicular Growth During Puberty in Boys With and Without a Left-sided Varicocele Recruiting NCT03540056
34 Role of Colored Doppler Sonography in Evaluation of Testicular Perfusion Before and After Varicocelectomy in Patients With Infertility Recruiting NCT03750370
35 The Role of Microsurgery in Surgical Treatment of Varicocele. Recruiting NCT02722187
36 The Comparison of TAP Block and QL Block on Postoperative Analgesic Consumption and Patient Satisfaction After Varicocele Surgery Recruiting NCT03793764
37 The Effect and Prognosis of Different Operations on Varicocele - a Single-center Clinical Study Active, not recruiting NCT01757548
38 The Search for Viral and Bacterial Etiology of Varicocele Active, not recruiting NCT03079609
39 The Effect of Preliminary Varicocele Repair on IVF Outcomes in Male Factor Infertility Not yet recruiting NCT03090438
40 Duplex US in Pelvic Congestion Syndrome in Females Not yet recruiting NCT03943381
41 Detection of Microdeletions in the Azoospermia Factor (AZF) Regions on the Human Y Chromosome in Infertile Male Patients Suspended NCT03497728
42 A Prospective, Multi-Centre, Randomized Controlled Study Comparing Varicocelectomy to Observation in Infertile Men With Clinical Varicoceles Terminated NCT00961558
43 Varicocelectomy: Can Sex-hormones Predict Improvements in Semen Quality? Terminated NCT01296230

Search NIH Clinical Center for Varicocele

Cochrane evidence based reviews: varicocele

Genetic Tests for Varicocele

Anatomical Context for Varicocele

MalaCards organs/tissues related to Varicocele:

40
Testis, Testes, Prostate, Heart, Kidney, Endothelial, Pituitary

Publications for Varicocele

Articles related to Varicocele:

(show top 50) (show all 4488)
# Title Authors PMID Year
1
[Azoospermia factor and male infertility]. 54 61
20369704 2010
2
The association between varicocele, premature ejaculation and prostatitis symptoms: possible mechanisms. 54 61
19674254 2009
3
Hormonal regulation of total antioxidant capacity in seminal plasma. 61 54
19234315 2009
4
Baseline follicle-stimulating hormone is a strong predictor for the outcome of the gonadotrophin-releasing hormone test in young men with unilateral medium- or high-grade varicocele. 61 54
16925763 2006
5
Human sperm sex hormone-binding globulin isoform: characterization and measurement by time-resolved fluorescence immunoassay. 54 61
16131577 2005
6
Varicocele ligation on free testosterone levels in infertile men with varicocele. 61 54
15669609 2004
7
Does the gonadotropin-releasing hormone stimulation test predict clinical outcomes after microsurgical varicocelectomy? 61 54
15183968 2004
8
The changes in testicular vascular permeability during progression of the experimental varicocele. 54 61
12507549 2003
9
AZF microdeletions associated with idiopathic and non-idiopathic cases with cryptorchidism and varicocele. 54 61
12508125 2002
10
Assessment of sperm functions in infertile patients with varicoceles. 61 54
12390086 2002
11
Varicocele as a progressive lesion: positive effect of varicocele repair. 54 61
11212075 2001
12
Predictive indicators of successful varicocele repair in men with infertility. 61 54
10997484 2000
13
Pituitary and testicular function in adolescents with varicocele. 61 54
10624500 1999
14
Serum inhibin B levels and the response to gonadotropin stimulation test in pubertal boys with varicocele. 61 54
10458399 1999
15
[Gonadotropin response to GnRH and seminal parameters in low grade varicocele]. 54 61
10193017 1999
16
Evaluation of the relationship between semen parameters, pregnancy rate of wives of infertile men with varicocele, and gonadotropin-releasing hormone test before and after varicocelectomy. 61 54
9801113 1998
17
[The naloxone test in patients with varicocele]. 54 61
9695347 1998
18
[Gonadotropin-releasing hormone (GnRH) in selecting patients for varicocelectomy]. 61 54
9153874 1997
19
The value of the gonadotrophin-releasing hormone test as a prognostic factor in infertile patients with varicocele. 61 54
8944523 1996
20
Free sex steroid and sex hormone-binding globulin levels in oligozoospermic men with varicoceles. 61 54
8690120 1996
21
[Hypothalamic-pituitary-gonadal damage in adolescents with varicocele]. 61 54
8935565 1996
22
The effect of smoking and varicocele on human sperm acrosin activity and acrosome reaction. 61 54
8822441 1995
23
Correlation of testicular volume, histology and LHRH test in adolescents with idiopathic varicocele. 61 54
7925532 1994
24
Serum levels of steroid hormones in men with varicocele and oligospermia as compared to normozoospermic men. 54 61
1305061 1992
25
Fructose, prostatic acid phosphatase and zinc levels in the seminal plasma of varicoceles. 61 54
1977719 1990
26
[Indices of testicular endosecretory function and of the status of the hypophyseal-gonadal system in varicocele]. 61 54
2368218 1990
27
Relevance of seminal F2-dihomo-IsoPs, F2-IsoPs and F4-NeuroPs in idiopathic infertility and varicocele. 61
32272165 2020
28
Expression of vascular endothelial growth factor and its receptors in infertile men with varicocele. 61
32361601 2020
29
Evaluation of clinical effects of microsurgical subinguinal varicocelectomy with and without testicular delivery. 61
32339320 2020
30
Association between seminal granulysin and malondialdehyde in infertile men with varicocele and the potential effect of varicocelectomy. 61
32271478 2020
31
Acute right epididymo-orchitis complicated by pampiniform plexus thrombosis. 61
32322510 2020
32
Soluble Fibrinogen-like protein 2 plays a role in varicocele induced male infertility. 61
32350910 2020
33
The predictive value of the platelet volume parameters in evaluation of varicocelectomy outcome in infertile patients. 61
32196717 2020
34
Effect of microsurgical varicocele repair on sexual functions and testosterone in hypogonadal infertile men with varicocele. 61
32475203 2020
35
Microstructures of the spermatic cord with three-dimensional reconstruction of sections of the cord and application to varicocele. 61
32202917 2020
36
Effects of liver-regulating herb compounds on testicular morphological and ultrastructural changes in varicocele rats through SCF/C-KIT pathway. 61
32478883 2020
37
Seminal plasma protein networks and enriched functions in varicocele: Effect of smoking. 61
32150769 2020
38
A preliminary study of the biochemical environment of infertile testes with clinical varicocele. 61
32334371 2020
39
Oxidative stress-related miRNAs in spermatozoa may reveal the severity of damage in grade III varicocele. 61
32478945 2020
40
Varicocele Embolization: An Assessment of the Quality and Readability of Online Patient Information. 61
31494004 2020
41
Etiologies of sperm DNA damage and its impact on male infertility. 61
32559347 2020
42
A change in the steroid metabolic pathway in human testes showing deteriorated spermatogenesis. 61
32151535 2020
43
Alpha- and gamma-tocopherol levels in human semen and their potential functional implications. 61
32065446 2020
44
Impact of intra-operative doppler ultrasound assistance during microsurgical varicocelectomy on operative outcome and sperm parameters. 61
32379354 2020
45
Hydrocele in recurrent acute pancreatitis caused by testicular venous obstruction: A case report of a rare complication (CARE-compliant). 61
32358347 2020
46
Testicular ultrasound (TU) score: a new proposal for a scoring system to predict testicular function. 61
32445591 2020
47
[Varicocele testis]. 61
32400385 2020
48
Testosterone amplifies HSP70-2a, HSP90 and PCNA expression in experimental varicocele condition: Implication for DNA fragmentation. 61
32461192 2020
49
Decisional Conflict and Knowledge Among Patients With Varicocele Seeking Treatment for Infertility. 61
32445765 2020
50
Early and Synergistic Recovery Effect of Herbal Combination on Surgically Corrected Varicocele. 61
31221940 2020

Variations for Varicocele

ClinVar genetic disease variations for Varicocele:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 46;XY;t(12;14)(q15;q13)matTranslocation Uncertain significance 267936

Expression for Varicocele

Search GEO for disease gene expression data for Varicocele.

Pathways for Varicocele

Pathways related to Varicocele according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1 12.57 NOS2 HSP90AA1 HIF1A GSTM1 CASP9 CASP3
2
Show member pathways
12.34 PRL NOS3 NOS2 CASP3
3
Show member pathways
12.27 PLCZ1 NOS3 NOS2 CASP9 CASP3
4
Show member pathways
12.22 NOS3 NOS2 HSP90AA1 CASP9
5
Show member pathways
12.07 NOS2 HSPA2 CASP9 CASP3
6 11.74 CAT CASP9 CASP3
7 11.72 NOS2 CASP9 CASP3
8
Show member pathways
11.71 NOS3 HSP90AA1 HIF1A
9 11.66 NOS3 NOS2 LDHC HIF1A
10
Show member pathways
11.64 NOS3 CASP9 CASP3
11 11.56 GSTM1 CASP9 CASP3
12 11.53 NOS3 HSP90AA1 CASP9 CASP3
13 11.41 HSPA2 CASP9 CASP3
14 11.37 NOS3 HSP90AA1 HIF1A
15
Show member pathways
11.23 NOS3 NOS2 HSPA2 HSP90AA1
16
Show member pathways
11.21 NOS3 NOS2 CAT
17 10.96 NOS2 HIF1A CASP9 CASP3
18 10.84 NOS3 NOS2 HIF1A CASP9 CASP3
19 10.77 HSP90AA1 HIF1A
20 10.67 NOS3 NOS2
21 10.41 NOS3 NOS2

GO Terms for Varicocele

Cellular components related to Varicocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.1 HSP90AA1 HIF1A CAT CASP9 ALB ACR

Biological processes related to Varicocele according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.95 HIF1A GNRH1 CAT CASP3 ALB
2 cytokine-mediated signaling pathway GO:0019221 9.86 NOS2 HSP90AA1 HIF1A CASP3
3 aging GO:0007568 9.78 GNRH1 CAT CASP9 AMH
4 response to hypoxia GO:0001666 9.73 NOS2 HIF1A CAT CASP3
5 response to UV GO:0009411 9.58 CAT CASP9 CASP3
6 nitric oxide biosynthetic process GO:0006809 9.54 NOS3 NOS2
7 response to heat GO:0009408 9.54 NOS3 HSPA2 HSP90AA1
8 cofactor metabolic process GO:0051186 9.52 NOS3 HSP90AA1
9 positive regulation of guanylate cyclase activity GO:0031284 9.51 NOS3 NOS2
10 arginine catabolic process GO:0006527 9.49 NOS3 NOS2
11 response to cobalt ion GO:0032025 9.46 CASP9 CASP3
12 response to organic cyclic compound GO:0014070 9.46 GNRH1 CASP9 CASP3 AMH
13 leukocyte apoptotic process GO:0071887 9.32 CASP9 CASP3
14 glial cell apoptotic process GO:0034349 9.26 CASP9 CASP3
15 response to antibiotic GO:0046677 9.13 HSP90AA1 CASP9 CASP3
16 response to lipopolysaccharide GO:0032496 9.02 NOS3 NOS2 GNRH1 CASP9 CASP3

Molecular functions related to Varicocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 FMN binding GO:0010181 9.46 NOS3 NOS2
2 cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 9.43 CASP9 CASP3
3 cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:0097200 9.4 CASP9 CASP3
4 cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097199 9.37 CASP9 CASP3
5 arginine binding GO:0034618 9.32 NOS3 NOS2
6 NADPH-hemoprotein reductase activity GO:0003958 9.26 NOS3 NOS2
7 tetrahydrobiopterin binding GO:0034617 9.16 NOS3 NOS2
8 NADP binding GO:0050661 9.13 NOS3 NOS2 CAT
9 nitric-oxide synthase activity GO:0004517 8.62 NOS3 NOS2

Sources for Varicocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....