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MCID: VRC005
MIFTS: 66

Varicose Veins

Categories: Blood diseases, Cardiovascular diseases, Skin diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Varicose Veins

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MalaCards integrated aliases for Varicose Veins:

Name: Varicose Veins 58 12 6 44 45 15 64 64
Varices 12 15
Venous Ectasia 12
Venous Varices 12
Varicosity 74
Varix 12

Characteristics:

OMIM:

58
Inheritance:
multifactorial vs. autosomal or x-linked dominant


HPO:

33
varicose veins:
Inheritance multifactorial inheritance x-linked dominant inheritance


Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Skin diseases Blood diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:799
OMIM 58 192200
MeSH 45 D014648
NCIt 51 C35114
SNOMED-CT 69 12856003
ICD10 34 I83.90
MedGen 43 C0042345
SNOMED-CT via HPO 70 128060009 399989005
UMLS 74 C0042345
Sources

Summaries for Varicose Veins

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MedlinePlus : 44 Varicose veins are swollen, twisted veins that you can see just under the skin. They usually occur in the legs, but also can form in other parts of the body. Hemorrhoids are a type of varicose vein. Your veins have one-way valves that help keep blood flowing toward your heart. If the valves are weak or damaged, blood can back up and pool in your veins. This causes the veins to swell, which can lead to varicose veins. Varicose veins are very common. You are more at risk if you are older, are female, have obesity, don't exercise, or have a family history of varicose veins. They can also be more common in pregnancy. Doctors often diagnose varicose veins from a physical exam. Sometimes you may need additional tests. Exercising, losing weight, elevating your legs when resting, and not crossing them when sitting can help keep varicose veins from getting worse. Wearing loose clothing and avoiding long periods of standing can also help. If varicose veins are painful or you don't like the way they look, your doctor may recommend procedures to remove them. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Varicose Veins, also known as varices, is related to budd-chiari syndrome and portal hypertension, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Varicose Veins is ELN (Elastin), and among its related pathways/superpathways are Integrin Pathway and Cytokine Signaling in Immune system. The drugs Propranolol and Carvedilol have been mentioned in the context of this disorder. Affiliated tissues include skin, spleen and testes, and related phenotypes are varicose veins and Reduced mammosphere formation

Disease Ontology : 12 A vein disease that is characterized by swollen, twisted veins visible just under the surface of the skin.

PubMed Health : 64 About varicose veins: Varicose (VAR-i-kos) veins are swollen, twisted veins that you can see just under the surface of the skin. These veins usually occur in the legs, but they also can form in other parts of the body.Varicose veins are a common condition. They usually cause few signs and symptoms. Sometimes varicose veins cause mild to moderate pain, blood clots, skin ulcers (sores), or other problems.

Wikipedia : 77 Varicose veins are superficial veins that have become enlarged and twisted. Typically they occur just... more...

Description from OMIM: 192200
Sources

Related Diseases for Varicose Veins

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Diseases related to Varicose Veins via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 533)
# Related Disease Score Top Affiliating Genes
1 budd-chiari syndrome 31.8 F2 F5 MTHFR SERPINC1
2 portal hypertension 31.5 F2 VEGFA VWF
3 chronic venous insufficiency 31.5 MMP1 MMP9 TIMP1
4 vascular disease 31.2 ELN F2 F5 MMP3 MMP9 MTHFR
5 venous insufficiency 31.2 F2 MMP1 MMP9 TIMP1 VWF
6 active peptic ulcer disease 30.9 F2 VWF
7 portal vein thrombosis 30.8 F2 F5 MTHFR SERPINC1
8 thrombophlebitis 30.8 F2 F5 MTHFR SERPINC1
9 thrombosis 30.7 F2 F5 MTHFR SERPINC1 VWF
10 vein disease 30.6 F2 F5 MTHFR SERPINC1 VEGFA
11 post-thrombotic syndrome 30.5 F2 F5 SERPINC1
12 inguinal hernia 30.5 ELN MMP1 MMP2 MMP9 TIMP1 TIMP2
13 arteriovenous malformation 30.4 MMP3 MMP9 VEGFA
14 thrombophilia due to thrombin defect 30.4 F2 F5 MTHFR SERPINC1 VWF
15 hepatoportal sclerosis 30.3 ELN F2
16 sudden sensorineural hearing loss 30.3 F2 F5 MTHFR
17 factor viii deficiency 30.2 F2 F5 VWF
18 pulmonary embolism 30.2 F2 F5 MTHFR SERPINC1 VWF
19 von willebrand's disease 30.1 F2 F5 VWF
20 limb ischemia 30.1 HIF1A VEGFA VWF
21 thrombophilia 30.1 F2 F5 MTHFR SERPINC1 VWF
22 intracranial embolism 30.0 F2 SERPINC1
23 aortic disease 30.0 ELN MMP2 MMP9
24 esophageal cancer 30.0 HIF1A MMP2 MMP7 MMP9 TIMP1 VEGFA
25 spinal stenosis 29.9 MMP3 TIMP1 TIMP2
26 cryptogenic cirrhosis 29.9 F2 F5 MTHFR
27 intravascular papillary endothelial hyperplasia 29.8 HIF1A VEGFA
28 disseminated intravascular coagulation 29.8 F2 F5 SERPINC1
29 arteries, anomalies of 29.8 MMP9 SERPINC1 VEGFA VWF
30 mesenteric vascular occlusion 29.8 F2 MTHFR
31 spinal cord infarction 29.5 F2 F5 MTHFR SERPINC1
32 protein s deficiency 29.5 F2 F5 MTHFR SERPINC1
33 protein c deficiency 29.5 F2 F5 MTHFR SERPINC1
34 patent foramen ovale 29.5 F2 F5 MTHFR SERPINC1
35 antiphospholipid syndrome 29.4 F2 F5 MTHFR SERPINC1 VWF
36 cerebrovascular disease 29.4 F2 F5 MMP9 MTHFR VWF
37 rheumatoid arthritis 29.3 MMP1 MMP3 MMP9 TIMP1 VEGFA
38 heart disease 29.2 ELN F2 MMP3 MTHFR SERPINC1 VEGFA
39 stroke, ischemic 29.2 F2 F5 MTHFR SERPINC1 VWF
40 colorectal cancer 28.8 HIF1A MMP1 MMP2 MMP7 MMP9 MTHFR
41 myocardial infarction 28.3 F2 F5 HIF1A MMP2 MMP3 MMP9
42 esophageal varix 12.4
43 colonic varices without portal hypertension 12.1
44 varicocele 11.9
45 klippel-trenaunay-weber syndrome 11.7
46 nodular regenerative hyperplasia 11.5
47 lymphedema-distichiasis syndrome 11.5
48 lymphatic malformation 7 11.4
49 cutis marmorata telangiectatica congenita 11.2
50 torticollis, keloids, cryptorchidism, and renal dysplasia 11.2

Graphical network of the top 20 diseases related to Varicose Veins:



Diseases related to Varicose Veins
Sources

Symptoms & Phenotypes for Varicose Veins

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Human phenotypes related to Varicose Veins:

33
# Description HPO Frequency HPO Source Accession
1 varicose veins 33 HP:0002619

Symptoms via clinical synopsis from OMIM:

58
Vascular:
varicose veins

Misc:
twice as frequent in females as in males

Clinical features from OMIM:

192200

UMLS symptoms related to Varicose Veins:


angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Varicose Veins according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 COL3A1 FOXC2 MMP2 MMP7 SERPINC1 TIMP1

MGI Mouse Phenotypes related to Varicose Veins:

47 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.36 AGGF1 COL3A1 F2 F5 FOXC2 HIF1A
2 homeostasis/metabolism MP:0005376 10.36 COL3A1 F2 F5 FOXC2 HIF1A MMP1
3 immune system MP:0005387 10.28 COL3A1 F2 FOXC2 HIF1A MMP1 MMP2
4 hematopoietic system MP:0005397 10.22 F2 HIF1A MMP2 MMP3 MMP7 MMP9
5 mortality/aging MP:0010768 10.21 AGGF1 COL3A1 F2 F5 FOXC2 HIF1A
6 digestive/alimentary MP:0005381 10.1 COL3A1 F2 FOXC2 HIF1A MMP7 MMP9
7 nervous system MP:0003631 10.07 AGGF1 F2 F5 FOXC2 HIF1A MMP2
8 liver/biliary system MP:0005370 9.95 COL3A1 F5 FOXC2 HIF1A MTHFR SERPINC1
9 neoplasm MP:0002006 9.92 AGGF1 HIF1A MMP1 MMP2 MMP7 MMP9
10 respiratory system MP:0005388 9.81 AGGF1 COL3A1 F2 FOXC2 HIF1A MMP2
11 skeleton MP:0005390 9.61 F2 FOXC2 HIF1A MMP2 MMP3 MMP9
12 vision/eye MP:0005391 9.23 FOXC2 HIF1A MMP2 MMP7 MMP9 MTHFR
Sources

Drugs & Therapeutics for Varicose Veins

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PubMedHealth treatment related to Varicose Veins: 64

Varicose veins are treated with lifestyle changes and medical procedures. The goals of treatment are to relieve symptoms, prevent complications, and improve appearance.If varicose veins cause few symptoms, your doctor may simply suggest making lifestyle changes. If your symptoms are more severe, your doctor may recommend one or more medical procedures. For example, you may need a medical procedure if you have a lot of pain, blood clots, or skin disorders caused by your varicose veins.Some people who have varicose veins choose to have procedures to improve how their veins look.Although treatment can help existing varicose veins, it can't keep new varicose veins from forming.

Drugs for Varicose Veins (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 317)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propranolol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 525-66-6 4946
2
Carvedilol Approved, Investigational Phase 4,Phase 3,Not Applicable 72956-09-3 2585
3
Nadolol Approved Phase 4,Phase 3 42200-33-9 39147
4
Racepinephrine Approved Phase 4,Not Applicable 329-65-7 838
5
Epinephrine Approved, Vet_approved Phase 4,Not Applicable 51-43-4 5816
6
Nitric Oxide Approved Phase 4,Phase 3,Phase 2 10102-43-9 145068
7
AT-101 Approved, Investigational Phase 4 90141-22-3, 652-67-5 12597
8
Isosorbide Dinitrate Approved, Investigational Phase 4 87-33-2 6883
9
Prazosin Approved Phase 4 19216-56-9 4893
10
Simvastatin Approved Phase 4,Phase 3,Phase 2,Not Applicable 79902-63-9 54454
11
Losartan Approved Phase 4 114798-26-4 3961
12
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198
13
Polidocanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9002-92-0
14 Ethiodized oil Approved, Investigational Phase 4,Phase 3,Not Applicable 8008-53-5
15
Octreotide Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 83150-76-9 6400441 383414
16
Terlipressin Approved, Investigational Phase 4,Phase 3,Not Applicable 14636-12-5 72081
17
Somatostatin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 38916-34-6, 51110-01-1 53481605
18
Entecavir Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 142217-69-4 153941
19
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
20
Thrombin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable
21
Ethanolamine oleate Approved Phase 4,Phase 3 2272-11-9
22
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
23
Ceftriaxone Approved Phase 4,Not Applicable 73384-59-5 5479530 5361919
24
Peginterferon alfa-2b Approved Phase 4,Phase 3 215647-85-1, 99210-65-8
25
Colchicine Approved Phase 4 64-86-8 2833 6167
26
Pantoprazole Approved Phase 4 102625-70-7 4679
27
Petrolatum Approved, Investigational Phase 4,Phase 2,Not Applicable 8009-03-8
28
Sodium Tetradecyl Sulfate Approved, Investigational Phase 4,Not Applicable 139-88-8, 1191-50-0 5248 14492
29
Esomeprazole Approved, Investigational Phase 4,Not Applicable 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
30
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
31
Ibuprofen Approved Phase 4,Not Applicable 15687-27-1 3672
32
Acetaminophen Approved Phase 4,Phase 1 103-90-2 1983
33
Tranexamic Acid Approved Phase 4 1197-18-8 5526
34
Telbivudine Approved, Investigational Phase 4,Not Applicable 3424-98-4 159269
35
Tenofovir Approved, Experimental, Investigational Phase 4,Not Applicable 147127-20-6 464205
36
Coal tar Approved Phase 4,Not Applicable 8007-45-2
37
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
38
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
39
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
40
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
41
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7440-70-2 271
42
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 68-26-8, 22737-96-8, 11103-57-4 9904001 445354
43 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Vasodilator Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Adrenergic Agents Phase 4,Phase 3,Phase 2,Not Applicable
46 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2,Not Applicable
47 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Not Applicable
48 Adrenergic beta-Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
49 Adrenergic Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
50 Adrenergic alpha-1 Receptor Antagonists Phase 4,Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 624)
# Name Status NCT ID Phase Drugs
1 Preventing Recurrent Bleeding After Eradication of Esophageal Varices Unknown status NCT02740166 Phase 4 propranolol
2 Early Feeding Following Ligation of Acute Bleeding Varices Unknown status NCT01287702 Phase 4
3 Primary Prevention of Patients With Hepatocellular Carcinoma and Concomitant Esophageal Varices Unknown status NCT01970748 Phase 4 Propranolol
4 The Effect of Carvedilol Vs Propranolol in Cirrhotic Patients With Variceal Bleeding Unknown status NCT02385422 Phase 4 Carvedilol;Propranolol
5 The Effect of Carvedilol VS Endoscopic Therapy in Primary Prophylaxis of High-risk Esophageal Gastric Variceal Bleeding Unknown status NCT02695732 Phase 4 Carvedilol
6 The Effect of Hepatic Vein Pressure Gradient(HVPG)-Guided Therapy in Cirrhotic Patients With Esophagogastric Varices Unknown status NCT02638415 Phase 4 Carvedilol
7 Endoscopic Treatment Alone Versus Combined Propranolol and Endoscopic Treatment of Acute Variceal Hemorrhage in Patients With Hepatocellular Carcinoma Unknown status NCT01451658 Phase 4 propranolol
8 Primary Prevention of Gastric Variceal Bleeding : Endoscopic Treatment Versus Non-selective Beta-blocker Unknown status NCT01298271 Phase 4 propranolol
9 Banding Ligation With Carvedilol Versus Carvedilol for the Prevention of First Bleeding Unknown status NCT01383044 Phase 4 carvedilol
10 Compression Aided Management of Edema in Patients With C3 Venous Disease Unknown status NCT00766974 Phase 4
11 Fluid Infusion During Breast Surgery Unknown status NCT00431743 Phase 4 Hydroxyethylstarch 130/0,4;Lactated Ringer's solution
12 RCT of Carvedilol Versus Variceal Band Ligation in the Primary Prophylaxis of Oesophageal Variceal Haemorrhage Unknown status NCT01070641 Phase 4 Carvedilol
13 Trial of Hemospray Plus Epinephrine Injection Versus Endoscopic Hemoclip Unknown status NCT02537353 Phase 4 Hemospray;Adrenaline
14 Treatment for Prevention of Variceal Rebleeding Guided by the Hemodynamic Response Unknown status NCT00563602 Phase 4
15 Hemodynamic Effect of Simvastatin With Beta Blockers in Clinical Portal Hypertension Unknown status NCT01282385 Phase 4 Simvastatin;placebo
16 Prevention of Decompensation in Liver Cirrhosis Unknown status NCT00239096 Phase 4 losartan (drug)
17 Juxta-CuresTM Versus Bandaging for Venous Ulcers Unknown status NCT02790593 Phase 4
18 A Study Of Pain And Quality Of Life Outcomes In Subjects With a Single Painful Venous Leg Ulcer Treated With Apligraf® Unknown status NCT02011724 Phase 4
19 Clinical Evaluation of the SNaP Wound Care System Unknown status NCT01113658 Phase 4
20 PROPRANOLOL PLUS LIGATION REDUCES RECURRENCE OF ESOPHAGEAL VARICES? Completed NCT01893541 Phase 4 PROPRANOLOL
21 Efficacy and Safety of Esarin Gel in Chronic Venous Insufficiency and Varicose Veins Completed NCT02346058 Phase 4 Esarin Gel
22 COMFORT: A Multicenter, Open-label, Randomized, Crossover Study Completed NCT02462720 Phase 4 Varithena®
23 Carvedilol as an Adjunct to Endoscopic Cyanoacrylate Injection for Secondary Prophylaxis of Gastric Variceal Bleeding Completed NCT02504723 Phase 4 carvedilol;cyanoacrylate
24 Time Interval for Endoscopic Variceal Ligation Completed NCT01291277 Phase 4
25 Surgery Versus Sclerotherapy for Isolated Accessory Great Saphenous Vein Varicosis Completed NCT02010723 Phase 4 sclerotherapy with aethoxysclerol foam
26 Study Protocol Comparing Polidocanol Versus Hypertonic Glucose for Treatment of Reticular Veins Completed NCT02054325 Phase 4 Polidocanol with Glucose;Glucose
27 A Randomized Controlled Trial Comparing Band Ligation and Cyanoacrylate Injection for Esophageal Varices Completed NCT00799851 Phase 4 cyanoacrylate injection
28 Hemodynamic Effects of Terlipressin and High Dose Octreotide Completed NCT02119884 Phase 4 Terlipressin;Octreotide
29 A Trial of Ligation Plus Nadolol Versus Nadolol Alone in the Prophylaxis of First Variceal Bleeding in Cirrhosis Completed NCT00921349 Phase 4 Nadolol
30 Polidocanol Versus Glucose Treatment of Telangiectasia Trial Completed NCT02657252 Phase 4 Glucose;Polidocanol with Glucose
31 Painless Local Infiltration Anesthesia Completed NCT01611324 Phase 4 Mepivacaine chlorhydrate 2% in Sodium Bicarbonate 1.4%;Mepivacaine chlorhydrate 2% with epinephrine in NS 0.9%
32 EVL (Endoscopic Variceal Ligation) Plus Vasoconstrictor vs.Ligation Plus PPI( Proton Pump Inhibitor) in the Control of Acute Esophageal Variceal Bleeding Completed NCT01112852 Phase 4 pantoloc 40 mg;somatostatin or terlipressin
33 Comparison of 3 Days and 7 Days Intravenous Ceftriaxone Prophylaxis for Variceal Bleeding Completed NCT00838864 Phase 4 ceftrioxone;ceftrioxone
34 Study on B-blockers to Prevent Decompensation of Cirrhosis With HTPortal Completed NCT01059396 Phase 4 propranolol;carvedilol;placebo
35 Comparison of Endoscopic Injection of Conventional and Double Doses Cyanoacrylate for Gastric Variceal Hemorrhage Completed NCT00735358 Phase 4
36 ClosureFAST vs. Laser Ablation for the Treatment of GSV Disease: A Multicenter, Single-Blinded, Randomized Study. Completed NCT00509392 Phase 4
37 The Safety & Efficacy of Terlipressin vs Octreotide for the Control of Variceal Bleed Completed NCT00534677 Phase 4 Terlipressin;Octreotide
38 A Trial of Nadolol Plus Isosorbide Mononitrate Versus Carvedilol for the Prevention of Variceal Rebleeding Completed NCT01103154 Phase 4 carvedilol;nadolol + ISMN
39 Comparison of Terlipressin, Somatostatin, and Octreotide for Control of Variceal Bleeding Completed NCT00966355 Phase 4 Terlipressin;Somatostatin;Octreotide
40 Short Course Terlipressin for Control of Acute Variceal Bleeding Completed NCT00369694 Phase 4 Terlipressin;Terlipressin & then Dummy
41 Radiofrequency Ablation vs Laser Ablation of the Incompetent Greater Saphenous Vein Completed NCT02236338 Phase 4
42 Peripheral Vascular Disease and Nerve Stimulation Completed NCT01942941 Phase 4
43 Secondary Prophylaxis After Variceal Bleeding in Non-Responders Completed NCT00450164 Phase 4 Nadolol;Isosorbide mononitrate;Prazosin
44 Optimized Treatment and Regression of HBV-induced Compensated Liver Cirrhosis Completed NCT01943617 Phase 4 Entecavir;Thymosin-α
45 Band Ligation Versus Transjugular Intrahepatic Portosystemic Stent Shunt (TIPS) in Cirrhotics With Recurrent Variceal Bleeding Non Responding to Medical Therapy Completed NCT00570973 Phase 4
46 Study of Long-term Peg Intron vs. Colchicine in Non-responders. Completed NCT00179413 Phase 4 PEG -Intron;Colchicine
47 Vasoactive Drugs in Real World Practice Completed NCT02757703 Phase 4 Somatostatin;Terlipressin;Pantoprazole
48 A Pilot Trial of the Use of ReCell® Autologous Cell Harvesting Device for Venous Leg Ulcers Completed NCT01743053 Phase 4
49 Trial on the Efficacy of Prontosan Wound Irrigation Solution and Prontosan Wound Gel Completed NCT01153633 Phase 4
50 Wound Fluid Protease Levels During Use of Novel Wound Dressing Completed NCT01567150 Phase 4

Search NIH Clinical Center for Varicose Veins

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: varicose veins

Sources

Genetic Tests for Varicose Veins

About this section
Sources

Anatomical Context for Varicose Veins

About this section

MalaCards organs/tissues related to Varicose Veins:

42
Skin, Spleen, Testes, Colon, Liver, Heart, Smooth Muscle
Sources

Publications for Varicose Veins

About this section

Articles related to Varicose Veins:

(show top 50) (show all 5250)
# Title Authors Year
1
The treatment of achalasia patients with esophageal varices: an international study. ( 31065374 )
2019
2
Esophageal Varices in Adolescent and Young Adult Males with Acute Lymphocytic Leukemia. ( 30335538 )
2019
3
Baveno-VI-Guided Prediction of Esogastric Varices in Primary Biliary Cholangitis. ( 30676377 )
2019
4
Non-Invasive Prediction of High-Risk Varices in Patients with Primary Biliary Cholangitis and Primary Sclerosing Cholangitis. ( 30315285 )
2019
5
Endovenous cyanoacrylate glue to treat varicose veins and chronic venous insufficiency-Experience gained from our first 100+ truncal venous ablations in a multi-ethnic Asian population using the Medtronic VenaSealâ„¢ Closure System. ( 30691376 )
2019
6
Association between varicose veins anatomical pattern and procedural complications following endovascular laser photothermolysis for chronic venous insufficiency. ( 30970086 )
2019
7
Cardiovascular Disease: Chronic Venous Insufficiency and Varicose Veins. ( 30995000 )
2019
8
Chronic venous insufficiency and varicose veins of the lower extremities. ( 30360023 )
2019
9
Isolated gastric varices in a patient with essential thrombocythemia. ( 30359570 )
2019
10
Relationship between various hepatic function scores and the formation of esophageal varices in patients with HIV/hepatitis C virus co-infection due to contaminated blood products for hemophilia. ( 30358037 )
2019
11
Popliteal Vein Aneurysm Associated with Varicose Veins, Hydrocele, and Multiple Congenital Osteomas: A Case Report and Review of the Literature. ( 30993108 )
2019
12
The Right Liver Lobe Size/Albumin Concentration Ratio in Identifying Esophageal Varices among Patients with Liver Cirrhosis. ( 31049180 )
2019
13
Acute mesenteric vein thrombosis after endoscopic injection sclerotherapy for esophageal varices in a patient with liver cirrhosis. ( 31080203 )
2019
14
Prediction of Aspartate Aminotransferase to Platelet Ratio Index with Size of Esophageal Varices in Liver Cirrhosis. ( 31110374 )
2019
15
Four-dimensional Flow MRI as a Marker for Risk Stratification of Gastroesophageal Varices in Patients with Liver Cirrhosis. ( 30325278 )
2019
16
Long-term outcome of endoscopic variceal band ligation of esophageal varices in patients with chronic liver disease. ( 30868452 )
2019
17
Evaluation of liver stiffness by 2D-SWE in combination with non-invasive parameters as predictors for esophageal varices in patients with advanced chronic liver disease. ( 30879344 )
2019
18
Elastography-based screening for esophageal varices in patients with advanced chronic liver disease. ( 30686900 )
2019
19
Pregnancy in a Woman with Latent Myeloproliferative Neoplasm Induced Chronic Portal Vein Thrombosis, Portal Cavernoma, and Gastric Varices. ( 31001438 )
2019
20
Recurrent Pulmonary Emboli from Pelvic Varices Despite Anticoagulation and Infrarenal Inferior Vena Cava Filter. ( 30717968 )
2019
21
Portal hypertension, oesophageal varices and caput medusae. ( 30295853 )
2019
22
Jejunal varices as a rare cause of recurrent gastrointestinal bleeding in a 74-year-old man with extrahepatic portal hypertension after pancreato-biliary surgery. ( 30872345 )
2019
23
Noninvasive Predictors of High-Risk Varices in Patients with Non-Cirrhotic Portal Hypertension. ( 30881946 )
2019
24
Varices on computed tomography are surrogate of clinically significant portal hypertension and can predict survival in compensated cirrhosis patients. ( 29900587 )
2019
25
Endovenous Treatment of Varicose Veins in Patients With Pyoderma Gangrenosum. ( 29933301 )
2019
26
Superficial Vein Thrombosis and Severe Varicose Veins Complicating Venous Thromboembolism. ( 30993952 )
2019
27
Jejunal Varices Bleeding in a Patient with Extensive Portomesenteric Thrombosis Secondary to Factor V Leiden Mutation: A Management Dilemma. ( 30881706 )
2019
28
Surgical intervention for varicose veins during pregnancy: Is it sensible? ( 30777989 )
2019
29
New, improved and less costly treatment for varicose veins. ( 30872822 )
2019
30
Steam ablation versus stripping of great saphenous varicose veins. ( 30872826 )
2019
31
Randomized clinical trial of mechanochemical and endovenous thermal ablation of great saphenous varicose veins. ( 30908611 )
2019
32
Weighted Gene Co-expression Network Analysis for RNA-Sequencing Data of the Varicose Veins Transcriptome. ( 30941060 )
2019
33
Review of article: Xin Li, Bo Yang, Xianlun Li, Shiyan Ren. Prospective comparison of effect of ligation and foam sclerotherapy with foam sclerotherapy alone for varicose veins. Ann Vasc Surg 2018;49:75-79. ( 30954202 )
2019
34
Varicose veins of lower extremities: Insights from the first large-scale genetic study. ( 30998689 )
2019
35
Pelvic congestion syndrome - treatment with pelvic varicose veins embolization. ( 31066803 )
2019
36
Varicose veins of the lower extremity secondary to tricuspid regurgitation. ( 31075472 )
2019
37
Varicose veins causing tibial nerve compression in the tarsal tunnel. ( 31079049 )
2019
38
Investigation and treatment of pelvic vein reflux associated with varicose veins: Current views and practice of 100 UK vascular specialists. ( 31084296 )
2019
39
Cardiac Doppler in patients with primary varicose veins of lower extremities. ( 31088217 )
2019
40
Randomized clinical trial of endovenous laser ablation versus direct and indirect radiofrequency ablation for the treatment of great saphenous varicose veins. ( 31095724 )
2019
41
Lymphatic flow restoration after stripping surgery for varicose veins: A case report. ( 31105958 )
2019
42
The haemodynamic causes of skin changes in limbs with primary varicose veins. ( 29726741 )
2019
43
Compression with 23 mmHg or 35 mmHg stockings after saphenous catheter foam sclerotherapy and phlebectomy of varicose veins: A randomized controlled study. ( 29754530 )
2019
44
Endovenous Management of Varicose Veins. ( 29874921 )
2019
45
Compression therapy for uncomplicated varicose veins - Too little for too much? ( 29954256 )
2019
46
Treatment of varicose veins, international consensus on which major complications to discuss with the patient: A Delphi study. ( 30012048 )
2019
47
Cyanoacrylate Embolization: A Novelty in the Field of Varicose Veins Surgery. ( 30099170 )
2019
48
Comparison of cyanoacrylate embolization and radiofrequency ablation for the treatment of varicose veins. ( 30114987 )
2019
49
Varicose veins due to reflux in a tortuous sartorius muscle vein. ( 30236914 )
2019
50
Tumescence Anesthesia Solution-Assisted Laser Ablation Treatment of Lower Limb Varicose Veins: The Effect of Temperature of the Tumescence Anesthesia Solution on Intraoperative and Postoperative Pain, Clinical Observations, and Comprehensive Nursing Care. ( 30309755 )
2019
Sources

Variations for Varicose Veins

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ClinVar genetic disease variations for Varicose Veins:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ELN NM_001278939.1(ELN): c.898A> T (p.Thr300Ser) single nucleotide variant Uncertain significance rs766735416 GRCh37 Chromosome 7, 73466262: 73466262
2 ELN NM_001278939.1(ELN): c.898A> T (p.Thr300Ser) single nucleotide variant Uncertain significance rs766735416 GRCh38 Chromosome 7, 74051932: 74051932
Sources

Expression for Varicose Veins

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Search GEO for disease gene expression data for Varicose Veins.
Sources

Pathways for Varicose Veins

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Pathways related to Varicose Veins according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Integrin Pathway 65
Show member pathways
 13.37 COL3A1 ELN F2 MMP1 MMP2 MMP3
2
Cytokine Signaling in Immune system 67
Show member pathways
 13.33 HIF1A MMP1 MMP2 MMP3 MMP9 TIMP1
3
Response to elevated platelet cytosolic Ca2+ 67
Show member pathways
 13.27 F2 F5 MMP1 SERPINC1 TIMP1 VEGFA
4
Pathways in cancer 38
12.78 HIF1A MMP1 MMP2 MMP9 VEGFA
5
Collagen chain trimerization 67
Show member pathways
 12.76 COL3A1 ELN F2 F5 MMP3 MMP7
6
Degradation of the extracellular matrix 67
Show member pathways
 12.63 COL3A1 ELN MMP1 MMP2 MMP3 MMP7
7
Proteoglycans in cancer 38
12.25 HIF1A MMP2 MMP9 VEGFA
8
G-protein signaling Ras family GTPases in kinase cascades (scheme) 23
Show member pathways
 12.25 HIF1A MMP1 MMP3 TIMP1 VEGFA
9
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 23
Show member pathways
 12.2 COL3A1 ELN F2 MMP1 MMP2 MMP3
10
Colorectal Cancer Metastasis 65
12.14 MMP1 MMP2 MMP7 MMP9 VEGFA
11
Formation of Fibrin Clot (Clotting Cascade) 67
Show member pathways
 12.13 F2 F5 SERPINC1 VWF
12
Complement and coagulation cascades 1 38
12.07 F2 F5 SERPINC1 VWF
13
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 12.01 F2 MMP2 MMP3 MMP7 MMP9
14
Interleukin-4 and 13 signaling 67
11.86 HIF1A MMP1 MMP2 MMP3 MMP9 TIMP1
15
HIF-1 signaling pathway 38
11.84 HIF1A TIMP1 VEGFA
16
AGE-RAGE signaling pathway in diabetic complications 38
11.84 COL3A1 MMP2 VEGFA
17
Rheumatoid arthritis 38
11.79 MMP1 MMP3 VEGFA
18
Bladder cancer 1 38
11.72 MMP1 MMP2 MMP9 VEGFA
19
Matrix Metalloproteinases 1
Show member pathways
 11.7 MMP1 MMP2 MMP3 MMP7 MMP9 TIMP1
20
AGE/RAGE pathway 1
11.67 HIF1A MMP2 MMP7 MMP9
21
Lung fibrosis 1
11.64 ELN MMP2 MMP9 TIMP1
22
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.6 MMP1 MMP2 MMP3 MMP9 VEGFA
23
Hepatitis C and Hepatocellular Carcinoma 1
11.52 HIF1A MMP1 VEGFA
24
Platelet Aggregation Inhibitor Pathway, Pharmacodynamics 62
11.52 COL3A1 F2 VWF
25
Angiogenesis (CST) 4
11.51 HIF1A MMP2 MMP3 MMP7 MMP9 TIMP1
26
Cell adhesion_Cell-matrix glycoconjugates 23
11.36 ELN MMP1 MMP3 MMP9 TIMP2
27
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.32 MMP1 MMP2 MMP9
28
Development_Leptin signaling via JAK/STAT and MAPK cascades 23
Show member pathways
 11.26 HIF1A TIMP1 VEGFA
29
IL1 and megakaryocytes in obesity 1
11.18 F2 MMP9 TIMP1 TIMP2
30
Angiogenesis (WikiPathways) 1
11.14 HIF1A MMP9 TIMP2 VEGFA
31
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 67
11.09 F2 MMP1 MMP2
32
Immune response_Oncostatin M signaling via JAK-Stat in human cells 23
11.04 MMP1 TIMP1 VEGFA
33
Cell adhesion_ECM remodeling 23
11.01 COL3A1 MMP1 MMP2 MMP3 MMP7 MMP9
34
Syndecan-1-mediated signaling events 1
10.97 MMP1 MMP7 MMP9
35
miR-148a/miR-31/FIH1/HIF1andalpha;-Notch signaling in glioblastoma 1
10.6 HIF1A VEGFA
Sources

GO Terms for Varicose Veins

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Cellular components related to Varicose Veins according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 AGGF1 COL3A1 ELN F2 F5 MMP1
2 endoplasmic reticulum lumen GO:0005788 9.77 COL3A1 F2 F5 SERPINC1 TIMP1
3 collagen-containing extracellular matrix GO:0062023 9.7 COL3A1 ELN MMP2 MMP9 SERPINC1 TIMP2
4 platelet alpha granule lumen GO:0031093 9.62 F5 TIMP1 VEGFA VWF
5 platelet alpha granule GO:0031091 9.4 F5 VWF
6 extracellular matrix GO:0031012 9.32 COL3A1 ELN MMP1 MMP2 MMP3 MMP7
7 extracellular space GO:0005615 10 COL3A1 F2 F5 MMP2 MMP3 MMP7

Biological processes related to Varicose Veins according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.91 AGGF1 HIF1A MMP2 VEGFA
2 extracellular matrix organization GO:0030198 9.9 COL3A1 ELN MMP9 VWF
3 blood coagulation GO:0007596 9.86 F2 F5 SERPINC1 VWF
4 positive regulation of endothelial cell proliferation GO:0001938 9.78 AGGF1 HIF1A VEGFA
5 response to cytokine GO:0034097 9.75 COL3A1 TIMP1 TIMP2
6 response to hormone GO:0009725 9.74 FOXC2 TIMP1 TIMP2
7 cellular protein metabolic process GO:0044267 9.73 F2 F5 MMP1 MMP2 SERPINC1 TIMP1
8 blood vessel development GO:0001568 9.72 COL3A1 FOXC2 HIF1A
9 outflow tract morphogenesis GO:0003151 9.71 ELN HIF1A VEGFA
10 platelet degranulation GO:0002576 9.71 F5 TIMP1 VEGFA VWF
11 cytokine-mediated signaling pathway GO:0019221 9.7 HIF1A MMP1 MMP2 MMP3 MMP9 TIMP1
12 response to hypoxia GO:0001666 9.67 HIF1A MMP2 MTHFR VEGFA
13 lactation GO:0007595 9.65 HIF1A SERPINC1 VEGFA
14 positive regulation of protein oligomerization GO:0032461 9.62 MMP1 MMP3
15 regulation of blood coagulation GO:0030193 9.62 F2 SERPINC1
16 hemostasis GO:0007599 9.62 F2 F5 SERPINC1 VWF
17 blood circulation GO:0008015 9.61 ELN F5 MTHFR
18 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.59 TIMP1 TIMP2
19 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.52 HIF1A TIMP1
20 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.51 HIF1A VEGFA
21 regulation of neuroinflammatory response GO:0150077 9.49 MMP3 MMP9
22 negative regulation of metallopeptidase activity GO:1905049 9.46 TIMP1 TIMP2
23 collagen catabolic process GO:0030574 9.35 MMP1 MMP2 MMP3 MMP7 MMP9
24 extracellular matrix disassembly GO:0022617 9.17 MMP1 MMP2 MMP3 MMP7 MMP9 TIMP1
25 proteolysis GO:0006508 10.06 F2 MMP1 MMP2 MMP3 MMP7 MMP9

Molecular functions related to Varicose Veins according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.87 MMP1 MMP2 MMP3 MMP7 MMP9 TIMP1
2 peptidase activity GO:0008233 9.85 F2 MMP1 MMP2 MMP3 MMP7 MMP9
3 heparin binding GO:0008201 9.71 F2 MMP7 SERPINC1 VEGFA
4 metallopeptidase activity GO:0008237 9.65 MMP1 MMP2 MMP3 MMP7 MMP9
5 endopeptidase activity GO:0004175 9.63 MMP1 MMP3 MMP9
6 serine-type endopeptidase activity GO:0004252 9.63 F2 MMP1 MMP2 MMP3 MMP7 MMP9
7 metalloendopeptidase inhibitor activity GO:0008191 9.48 TIMP1 TIMP2
8 metalloendopeptidase activity GO:0004222 9.35 MMP1 MMP2 MMP3 MMP7 MMP9
9 protease binding GO:0002020 9.02 COL3A1 SERPINC1 TIMP1 TIMP2 VWF
10 protein binding GO:0005515 10.36 AGGF1 COL3A1 ELN F2 F5 FOXC2
Sources

Sources for Varicose Veins

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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