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VARIX
MCID: VRC005
MIFTS: 59

Varicose Veins (VARIX)

Categories: Blood diseases, Cardiovascular diseases, Skin diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Varicose Veins

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MalaCards integrated aliases for Varicose Veins:

Name: Varicose Veins 57 12 6 42 44 15 62 62
Varices 12 15
Venous Ectasia 12
Venous Varices 12
Varicosity 70
Varix 12

Characteristics:

OMIM®:

57 (Updated 20-May-2021)
Inheritance:
multifactorial vs. autosomal or x-linked dominant


HPO:

31
varicose veins:
Inheritance multifactorial inheritance x-linked dominant inheritance


Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Skin diseases Blood diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:799
OMIM® 57 192200
MeSH 44 D014648
NCIt 50 C35114
SNOMED-CT 67 276504003
ICD10 32 I83.90
MedGen 41 C0042345
SNOMED-CT via HPO 68 128060009 12856003 399989005
UMLS 70 C0042345
Sources

Summaries for Varicose Veins

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MedlinePlus : 42 Varicose veins are swollen, twisted veins that you can see just under the skin. They usually occur in the legs, but also can form in other parts of the body. Hemorrhoids are a type of varicose vein. Your veins have one-way valves that help keep blood flowing toward your heart. If the valves are weak or damaged, blood can back up and pool in your veins. This causes the veins to swell, which can lead to varicose veins. Varicose veins are very common. You are more at risk if you are older, are female, have obesity, don't exercise, or have a family history of varicose veins. They can also be more common in pregnancy. Doctors often diagnose varicose veins from a physical exam. Sometimes you may need additional tests. Exercising, losing weight, elevating your legs when resting, and not crossing them when sitting can help keep varicose veins from getting worse. Wearing loose clothing and avoiding long periods of standing can also help. If varicose veins are painful or you don't like the way they look, your doctor may recommend procedures to remove them. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Varicose Veins, also known as varices, is related to klippel-trenaunay-weber syndrome and pelvic varices, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Varicose Veins is ELN (Elastin), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Midazolam and Ropivacaine have been mentioned in the context of this disorder. Affiliated tissues include liver, spleen and heart, and related phenotypes are varicose veins and homeostasis/metabolism

Disease Ontology : 12 A vein disease that is characterized by swollen, twisted veins visible just under the surface of the skin.

PubMed Health : 62 About varicose veins: Varicose (VAR-i-kos) veins are swollen, twisted veins that you can see just under the surface of the skin. These veins usually occur in the legs, but they also can form in other parts of the body. Varicose veins are a common condition. They usually cause few signs and symptoms. Sometimes varicose veins cause mild to moderate pain, blood clots, skin ulcers (sores), or other problems.

Wikipedia : 73 Varicose veins, also known as varicoses, are a medical condition in which superficial veins become... more...

More information from OMIM: 192200
Sources

Related Diseases for Varicose Veins

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Diseases related to Varicose Veins via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 898)
# Related Disease Score Top Affiliating Genes
1 klippel-trenaunay-weber syndrome 32.7 FOXC2 F2 AGGF1
2 pelvic varices 32.0 TNF SHBG IL6
3 varicocele 32.0 TNF SHBG MTHFR IL6 HIF1A
4 budd-chiari syndrome 31.9 SERPINC1 MTHFR F2
5 venous insufficiency 31.6 VWF VEGFA TIMP1 MTHFR MMP9 MMP1
6 chronic venous insufficiency 31.6 VEGFA TIMP2 TIMP1 MTHFR MMP9 MMP1
7 thrombophlebitis 31.6 VWF SERPINC1 MTHFR F2
8 lipodermatosclerosis 31.4 VEGFA TIMP2 MMP1
9 portal hypertension 31.3 VWF VEGFA TNF F2 ELN
10 thrombosis 31.2 VWF SERPINC1 MTHFR F2
11 post-thrombotic syndrome 31.2 SERPINC1 IL6 F2
12 pulmonary embolism 31.2 VWF SERPINC1 MTHFR F2
13 hemorrhoid 31.2 TNF MMP9 F2
14 thrombophilia due to thrombin defect 31.1 VWF SERPINC1 MTHFR F2
15 vascular disease 31.0 VWF VEGFA TNF TIMP1 SERPINC1 MTHFR
16 cellulitis 30.9 TNF IL6 F2
17 gastric ulcer 30.9 TNF MMP9 IL6
18 thrombophilia 30.8 VWF SERPINC1 MTHFR F2
19 inguinal hernia 30.7 TIMP2 TIMP1 MMP9 MMP2 MMP1 IL6
20 pyoderma 30.7 TNF MMP9 MMP1
21 pyoderma gangrenosum 30.7 TNF MMP9 MMP1
22 patent foramen ovale 30.6 VWF SERPINC1 MTHFR F2
23 fasciitis 30.6 TNF MMP1 IL6
24 portal vein thrombosis 30.6 SERPINC1 MTHFR F2
25 liver cirrhosis 30.6 VEGFA TNF TIMP2 TIMP1 SERPINC1 MMP2
26 mitral valve disease 30.6 MMP1 F2 ELN
27 alcoholic liver cirrhosis 30.6 TNF IL6 F2
28 vein disease 30.5 VWF VEGFA TNF SERPINC1 MTHFR MIR202
29 sclerosing cholangitis 30.5 TNF IL6 F2
30 aspiration pneumonia 30.4 TNF IL6 F2
31 aortic aneurysm 30.4 MMP9 MMP2 IL6 ELN
32 hemangioma 30.4 VWF VEGFA MMP9 IL6 HIF1A F2
33 cutis laxa 30.4 MMP9 MMP3 MMP2 MMP1 ELN
34 mitral valve stenosis 30.4 VWF SERPINC1 F2
35 obstructive jaundice 30.4 TNF IL6 F2
36 factor viii deficiency 30.4 VWF SERPINC1 F2
37 intraocular pressure quantitative trait locus 30.4 VEGFA TIMP2 MMP1 FOXC2 ELN
38 polycythemia 30.3 VEGFA SERPINC1 HIF1A F2
39 protein c deficiency 30.3 SERPINC1 MTHFR F2
40 placental abruption 30.3 SERPINC1 MTHFR F2
41 peripheral artery disease 30.3 VWF VEGFA TNF IL6 HIF1A
42 adult respiratory distress syndrome 30.3 TNF IL6 F2 ELN
43 meningitis 30.2 VEGFA TNF MMP9 IL6
44 hepatic encephalopathy 30.2 TNF MMP9 IL6 F2
45 myopia 30.2 VEGFA TIMP2 TIMP1 MMP3 MMP2 MMP1
46 intracranial embolism 30.2 VWF SERPINC1 F2
47 scoliosis 30.2 TIMP2 MMP9 MMP3 IL6 ELN
48 atrial heart septal defect 30.2 SERPINC1 MTHFR F2 ELN
49 exanthem 30.2 VEGFA TNF IL6 F2
50 relapsing-remitting multiple sclerosis 30.2 TNF TIMP1 MMP9 IL6

Graphical network of the top 20 diseases related to Varicose Veins:



Diseases related to Varicose Veins
Sources

Symptoms & Phenotypes for Varicose Veins

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Human phenotypes related to Varicose Veins:

31
# Description HPO Frequency HPO Source Accession
1 varicose veins 31 HP:0002619

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
Vascular:
varicose veins

Misc:
twice as frequent in females as in males

Clinical features from OMIM®:

192200 (Updated 20-May-2021)

UMLS symptoms related to Varicose Veins:


angina pectoris; chest pain; edema

MGI Mouse Phenotypes related to Varicose Veins:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 F2 FOXC2 HIF1A IL6 MMP1 MMP2
2 cardiovascular system MP:0005385 10.27 AGGF1 F2 FOXC2 HIF1A IL6 MMP2
3 immune system MP:0005387 10.21 F2 FOXC2 HIF1A IL6 MMP1 MMP2
4 digestive/alimentary MP:0005381 10.03 F2 FOXC2 HIF1A IL6 MMP9 TNF
5 nervous system MP:0003631 10 AGGF1 F2 FOXC2 HIF1A IL6 MMP2
6 muscle MP:0005369 9.97 F2 FOXC2 HIF1A IL6 MMP2 MMP9
7 neoplasm MP:0002006 9.91 AGGF1 HIF1A IL6 MMP1 MMP2 MMP9
8 respiratory system MP:0005388 9.65 AGGF1 F2 FOXC2 HIF1A IL6 MMP2
9 skeleton MP:0005390 9.36 F2 FOXC2 HIF1A IL6 MMP2 MMP3
Sources

Drugs & Therapeutics for Varicose Veins

About this section

PubMed Health treatment related to Varicose Veins: 62

Varicose veins are treated with lifestyle changes and medical procedures. The goals of treatment are to relieve symptoms, prevent complications, and improve appearance. If varicose veins cause few symptoms, your doctor may simply suggest making lifestyle changes. If your symptoms are more severe, your doctor may recommend one or more medical procedures. For example, you may need a medical procedure if you have a lot of pain, blood clots, or skin disorders caused by your varicose veins. Some people who have varicose veins choose to have procedures to improve how their veins look. Although treatment can help existing varicose veins , it can't keep new varicose veins from forming.

Drugs for Varicose Veins (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 208)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
2
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
3
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
4
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
5
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
6
Somatostatin Approved, Investigational Phase 4 51110-01-1, 38916-34-6 53481605
7
Nadolol Approved Phase 4 42200-33-9 39147
8
Ethiodized oil Approved, Investigational Phase 4 8008-53-5
9
Ethanolamine oleate Approved Phase 4 2272-11-9
10
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
11
Pantoprazole Approved Phase 4 102625-70-7 4679
12
Rifaximin Approved, Investigational Phase 4 80621-81-4 6436173 46783403
13
Nitric Oxide Approved Phase 4 10102-43-9 145068
14
Isosorbide Dinitrate Approved, Investigational Phase 4 87-33-2 6883
15
AT-101 Approved, Investigational Phase 4 90141-22-3, 652-67-5 12597
16
Lactulose Approved Phase 4 4618-18-2 11333
17
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
18
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
19
Prazosin Approved Phase 4 19216-56-9 4893
20
Octreotide Approved, Investigational Phase 4 83150-76-9 383414 6400441
21
Terlipressin Approved, Investigational Phase 4 14636-12-5 72081
22
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
23
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
24
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
25
Racepinephrine Approved Phase 4 329-65-7 838
26
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
27
Ibuprofen Approved Phase 4 15687-27-1 3672
28
Hesperidin Approved, Investigational Phase 4 520-26-3 53477767
29
Aspartic acid Approved, Nutraceutical Phase 4 56-84-8 5960
30
Ornithine Approved, Nutraceutical Phase 4 70-26-8, 3184-13-2 6262
31 Psychotropic Drugs Phase 4
32 Anti-Anxiety Agents Phase 4
33 GABA Modulators Phase 4
34 Liver Extracts Phase 4
35 Anti-Arrhythmia Agents Phase 4
36 Vasodilator Agents Phase 4
37 Adrenergic Antagonists Phase 4
38 Anti-Infective Agents Phase 4
39 Adrenergic alpha-1 Receptor Antagonists Phase 4
40 Adrenergic alpha-Antagonists Phase 4
41 Salicylates Phase 4
42 Hormone Antagonists Phase 4
43 N-Methylaspartate Phase 4
44 Antacids Phase 4
45 Anti-Ulcer Agents Phase 4
46 diuretics Phase 4
47 isosorbide-5-mononitrate Phase 4
48 Sympatholytics Phase 4
49 Antineoplastic Agents, Hormonal Phase 4
50 Gastrointestinal Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 407)
# Name Status NCT ID Phase Drugs
1 The Impact of Early Feeding Following Ligation of the Acute Bleeding Varices Unknown status NCT01287702 Phase 4
2 Does the Preoperative Midazolam Dose Affect Postoperative Pain? - a Multicentric Randomized Controlled Trial in Ambulatory Surgery Unknown status NCT03534895 Phase 4 Midazolam Injectable Solution;Postoperative analgesia;Rescue analgesia;Wound infiltration;Analgesia at home
3 Banding Ligation Plus Propranolol Versus Banding Ligation to Prevent Rebleeding of Esophageal Varices Unknown status NCT02740166 Phase 4 propranolol
4 RCT of Carvedilol vs Variceal Band Ligation in the Primary Prophylaxis of Oesophageal Variceal Haemorrhage Unknown status NCT01070641 Phase 4 Carvedilol
5 The Effect of HVPG-Guided Individualized Therapy in Patients With Cirrhosis Related Esophagogastric Variceal Hemorrhage For Secondary Prophylaxis:A Randomized Controlled Trial Unknown status NCT02638415 Phase 4 Carvedilol
6 The Effect of Carvedilol Vs Propranolol in Patients With Cirrhosis Related Esophagogastric Varices After Multiple Endoscopic Treatments For Secondary Prophylaxis:A Randomized Controlled Trial Unknown status NCT02385422 Phase 4 Carvedilol;Propranolol
7 Primary Prophylaxis of High-risk Esophageal Gastric Variceal Bleeding Comparing Carvedilol and Endoscopic Therapy: A Multicenter Randomized Controlled Trial Unknown status NCT02695732 Phase 4 Carvedilol
8 Prevention of Esophageal Variceal Rebleeding Unknown status NCT00863837 Phase 4 terlipressin (vasoconstrictor);pantoloc (proton pump inhibitor)
9 Randomized and Controlled Study of Endoscopic Ligation, Nadolol and Isosorbide Mononitrate vs Endoscopic Ligation and Nadolol Alone, or Associated With Isosorbide Mononitrate or Prazosin, Depending of the Hemodinamyc Response Unknown status NCT00563602 Phase 4
10 Endoscopic Treatment Alone Versus Combined Propranolol and Endoscopic Treatment of Acute Variceal Hemorrhage in Patients With HCC:a Randomized Trial Unknown status NCT01298284 Phase 4 propranolol
11 Polidocanol Versus Glucose For Sclerotherapy Treatment Of Telangiectasia Of The Lower Limbs: Protocol For A Randomized, Controlled Clinical Trial Completed NCT02657252 Phase 4 Glucose;Polidocanol with Glucose
12 A Randomized Triple-blind Study Protocol Comparing Polidocanol Versus Hypertonic Glucose for Sclerotherapy in Treatment of Reticular Veins at the Lower Limbs. Completed NCT02054325 Phase 4 Polidocanol with Glucose;Glucose
13 Study of Antiinflammatory Effects of Detralex (Daflon) in Patients With Chronic Venous Disease Completed NCT01654016 Phase 4 Detralex
14 PROPRANOLOL ASSOCIATED WITH ENDOSCOPIC BAND LIGATION REDUCES RECURRENCE OF ESOPHAGEAL VARICES FOR PRIMARY PROPHYLAXIS OF VARICEAL BLEEDING?: A RANDOMIZED CONTROLLED TRIAL Completed NCT01893541 Phase 4 PROPRANOLOL
15 Comparison of Surgery Versus Foam Sclerotherapy for Isolated Accessory Great Saphenous Vein Varicosis Completed NCT02010723 Phase 4 sclerotherapy with aethoxysclerol foam
16 Multicenter Study to Evaluate Pain Following Treatment of Varicose Vein With Varithena® Compared to Radiofrequency Ablation Completed NCT02462720 Phase 4 Varithena®
17 Efficacy of Alkalinised 2% Mepivacaine for Local Infiltration Anesthesia, in Ambulatory Phlebectomy Completed NCT01611324 Phase 4 Mepivacaine chlorhydrate 2% in Sodium Bicarbonate 1.4%;Mepivacaine chlorhydrate 2% with epinephrine in NS 0.9%
18 Evaluate the Efficacy and Safety of Esarin Gel in the Treatment of Chronic Venous Insufficiency or Varicose Vein Combine With Superficial Vein Thrombophlebitis in Outpatient Completed NCT02346058 Phase 4 Esarin Gel
19 Short-course Somatostatin Versus Terlipressin Infusion in Combination With Endoscopic Variceal Ligation for the Prevention of Early Esophageal Variceal Rebleeding Completed NCT02757703 Phase 4 Somatostatin;Terlipressin;Pantoprazole
20 Comparison of Endoscopic Injection of Conventional and Double Doses Cyanoacrylate for Gastric Variceal Hemorrhage Completed NCT00735358 Phase 4
21 A Randomized, Controlled, Multicentric Trial Comparing Endoscopic Band Ligation Versus Ransjugular Intrahepatic Portosystemic Stent Shunt in Cirrhotic Patients With Recurrent Variceal Bleeding Non Responding to Medical Therapy Completed NCT00570973 Phase 4
22 Efficacy of Terlipressin Therapy in Acute Variceal Haemorrhage After Endoscopic Variceal Ligation: A Randomised Controlled Clinical Trial Completed NCT03584087 Phase 4 Normal Saline;Terlipressin
23 Carvedilol Plus Endoscopic Cyanoacrylate Injection Versus Endoscopic Cyanoacrylate Injection for Secondary Prophylaxis of Gastric Variceal Bleeding Completed NCT02504723 Phase 4 carvedilol;cyanoacrylate
24 Comparison of 3 Days and 7 Days Intravenous Ceftriaxone Prophylaxis in Patients With Acute Variceal Bleeding Completed NCT00838864 Phase 4 ceftrioxone;ceftrioxone
25 A Randomized, Controlled Trial of Ligation Plus Vasoconstrictor vs.Ligation Plus Proton Pump Inhibitor in the Control of Acute Esophageal Variceal Bleeding Completed NCT01112852 Phase 4 pantoloc 40 mg;somatostatin or terlipressin
26 Hemodynamic Effects of Terlipressin and High Dose Octreotide on Patients With Liver Cirrhosis Related Esophageal Varices: A Randomized, Placebo-controlled Multicenter Trial Completed NCT02119884 Phase 4 Terlipressin;Octreotide
27 Endoscopic Treatment of Esophageal Varices in Advanced Liver Disease Patients: a Randomized Controlled Trial Comparing Band Ligation and Cyanoacrylate Injection Completed NCT00799851 Phase 4 cyanoacrylate injection
28 Efficacy And Safety Of Terlipressin Vs Octreotide As Adjuvant Therapy In Bleeding Esophageal Varices Completed NCT00534677 Phase 4 Terlipressin;Octreotide
29 Appropriate Time Interval for Repeat Sessions of Endoscopic Ligation for the Eradication of Esophageal Varices Completed NCT01291277 Phase 4
30 A Randomized, Controlled Trial of Ligation Plus Nadolol Versus Nadolol Alone in the Prophylaxis of First Variceal Bleeding in Cirrhosis Completed NCT00921349 Phase 4 Nadolol
31 RCT for the Effect of Early Administration of Vasoactive Substances When Combined With Endoscopic Treatment in Acute Gastro-esophageal Variceal Bleeds: Comparisons Among Terlipressin, Somatostatin, and Octreotide Completed NCT00966355 Phase 4 Terlipressin;Somatostatin;Octreotide
32 A Controlled Trial of Nadolol Plus Isosorbide Mononitrate vs. Carvedilol for the Prevention of Variceal Rebleeding Completed NCT01103154 Phase 4 carvedilol;nadolol + ISMN
33 Effects of Different Omeprazole Dosing on Gastric pH in Non- Variceal Upper Gastrointestinal Bleeding: A Randomized Prospective Study Completed NCT03980496 Phase 4 Omeprazole
34 Evaluation Of The Efficacy, Tolerance And Acceptability Of URGO Dressing 310 3082 Versus A Hydrofibre Dressing In The Local Management Of Venous Or Predominantly Venous Mixed Leg Ulcers Completed NCT01449422 Phase 4
35 Multicenter, Randomized, Double-blind, Placebo-controlled Study on the Effectiveness of Treatment With Beta-blockers to Prevent Decompensation of Cirrhosis With Portal Hypertension Completed NCT01059396 Phase 4 propranolol;carvedilol;placebo
36 Randomized Double Blind Dummy Controlled Trial Of 24 Versus 72 Hours Of Terlipressin As An Adjuvant Therapy In Acute Variceal Bleed Completed NCT00369694 Phase 4 Terlipressin;Terlipressin & then Dummy
37 The Dissemination of Consensus Recommendations on the Management of Canadian Patients With Non Variceal Upper Gastrointestinal Bleeding: A National Cluster Randomized Trial of a Multifaceted Tailored Implementation Strategy Completed NCT00840008 Phase 4
38 Comparison of Three Different Schemes:Lactulose, L-ornithine L-aspartate, or Rifaximin, Versus Placebo, as Primary Prophylaxis of the Development of Hepatic Encephalopathy After Acute Variceal Bleeding in Cirrhotic Patients Completed NCT02158182 Phase 4 Lactulose;L-ornithine L-aspartate;Rifaximin;Placebo
39 Secondary Prophylaxis After Variceal Bleeding: Combined Treatment With Endoscopic Ligation and Nadolol Against Nadolol Associated With Mononitrate of Isosorbide or Prazosin According to Hemodynamic Response. Completed NCT00450164 Phase 4 Nadolol;Isosorbide mononitrate;Prazosin
40 A Randomized Controlled Study on the Effects of PPIs on Gastroesophageal Variceal Bleeding in Liver Cirrhosis (PPIs: Proton Pump Inhibitors) Completed NCT03175731 Phase 4 Proton Pump Inhibitors;Placebo
41 Randomised Controlled Trial of Foam Sclerotherapy Versus Ambulatory Phlebectomy for the Treatment of Varicose Vein Tributaries Recruiting NCT03416413 Phase 4 Foam sclerotherapy
42 Impact of Nonselective Beta-blocker on Acute Kidney Injury in Cirrhotic Patients With Esophageal Varices Recruiting NCT04074473 Phase 4 propranolol
43 Endoscopic Treatment Versus Propranolol for Primary Prevention of Patients With Hepatocellular Carcinoma and Concomitant Esophageal Varices Recruiting NCT01970748 Phase 4 Propranolol
44 Comparison of 24-hours Versus 72-hours of Octreotide Infusion Along With Endoscopic Therapy in Preventing Early Rebleed From Esophageal Varices: a Multi-center, Randomized Clinical Study Recruiting NCT03624517 Phase 4 Octreotide
45 Beta-blockers or Placebo for Primary Prophylaxis of Oesophageal Varices (BOPPP Trial). A Blinded, Multi-centre, Clinical Effectiveness and Cost-effectiveness Randomised Controlled Trial Recruiting NCT03776955 Phase 4 Carvedilol
46 Antibiotic Prophylaxis in Patients Undergoing Endoscopic Injection of Cyanoacrylate for Primary and Secondary Prevention of Gastric Variceal Bleeding Recruiting NCT04140578 Phase 4 Ertapenem
47 Randomized Controlled Trial Comparing Propranolol, Endoscopic Banding Ligation, and Combined Treatment to Prevent First Variceal Hemorrhage in Patients With Liver Cirrhosis Recruiting NCT00965900 Phase 4 Propranolol
48 RCT Comparing the Efficacies of Endoscopic Variceal Ligation (EBL) and Combined Treatment of Beta-blocker and EBL for the Prevention of Esophageal Variceal Rebleeding Recruiting NCT00966121 Phase 4
49 RCT Comparing the Efficacies of Endoscopic Band Ligation (EBL) and Combined Treatment of Beta-blocker and EBL for the Prevention of Esophageal Variceal Rebleeding in Patients With Previous Endoscopic Variceal Treatment Recruiting NCT00966082 Phase 4
50 Endoscopic Treatment Alone Versus Combined Propranolol and Endoscopic Treatment of Acute Variceal Hemorrhage in Patients With Hepatocellular Carcinoma Recruiting NCT01451658 Phase 4 propranolol

Search NIH Clinical Center for Varicose Veins

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Sodium Morrhuate
Sodium Tetradecyl Sulfate

Cochrane evidence based reviews: varicose veins

Sources

Genetic Tests for Varicose Veins

About this section
Sources

Anatomical Context for Varicose Veins

About this section

MalaCards organs/tissues related to Varicose Veins:

40
Liver, Spleen, Heart, Skin, Kidney, Colon, Endothelial
Sources

Publications for Varicose Veins

About this section

Articles related to Varicose Veins:

(show top 50) (show all 20257)
# Title Authors PMID Year
1
Linkage to the FOXC2 region of chromosome 16 for varicose veins in otherwise healthy, unselected sibling pairs. 57 61
15744037 2005
2
A contribution to the problem of the inheritance of primary varicose veins. 61 57
4435791 1974
3
Genetics of varicose veins of the lower extremities. 57 61
5365895 1969
4
Efficacy and safety of Buyang Huanwu decoction in the treatment of varicose veins of the lower extremities: A protocol of randomized controlled trial. 42 61
33663075 2021
5
Efficacy and safety of polidocanol in the treatment of varicose veins of lower extremities: A protocol for systematic review and meta-analysis. 61 42
33663056 2021
6
Familiar congenital absence of valves in the deep leg veins. 57
4426629 1974
7
The heredity of venous insufficiency. 57
13561707 1958
8
Comparison of high ligation of great saphenous vein using pneumatic tourniquets and conventional method for great saphenous vein varicosis. 42
32871947 2020
9
Long-term kidney and liver outcome in 50 children with autosomal recessive polycystic kidney disease. 61
33165639 2021
10
Prevention of variceal rebleeding in cirrhotic patients with spontaneous portosystemic shunts: transjugular intrahepatic portosystemic shunt versus endoscopic treatment. 61
33731589 2021
11
Complications and management of elective endoscopic cyanoacrylate injection with lauromacrogol for gastric varices. 61
33731585 2021
12
Venous thromboembolism after ultrasound guided foam sclerotherapy. 61
33019844 2021
13
Laparoscopic real-time vessel navigation using indocyanine green fluorescence during the laparoscopic-Warshaw technique: First clinical experience. 61
33723184 2021
14
Jejunal variceal rupture in a patient with myelofibrosis: a case report. 61
33675010 2021
15
Cardiac Surgery in Patients With Liver Cirrhosis (CASTER) Study: Early and Long-Term Outcomes. 61
32919974 2021
16
Validation of the Expanded Baveno-VI Criteria for Screening Gastroscopy in Asian Patients with Compensated Advanced Chronic Liver Disease. 61
32440746 2021
17
Effects of Primary Biliary Cholangitis on Quality of Life and Health Care Costs in the United Kingdom. 61
32562892 2021
18
Primary undifferentiated pleomorphic cardiac sarcoma presenting as right heart failure. 61
33552334 2021
19
Initial Experience With Endoscopic Ultrasound-guided Coil Placement for Pediatric Gastric Variceal Hemostasis. 61
33394889 2021
20
The Role of Video Capsule Endoscopy in Liver Disease. 61
33743931 2021
21
Systemic inflammation increases across distinct stages of advanced chronic liver disease and correlates with decompensation and mortality. 61
33075344 2021
22
Diagnostic accuracy of spleen stiffness to evaluate portal hypertension and esophageal varices in chronic liver disease: a systematic review and meta-analysis. 61
32974686 2021
23
Diagnostic accuracy of liver and spleen stiffness measured by fibroscan® in the prediction of esophageal varices in HCV-related cirrhosis patients treated with oral antivirals. 61
33097282 2021
24
Including Ratio of Platelets to Liver Stiffness Improves Accuracy of Screening for Esophageal Varices That Require Treatment. 61
32562889 2021
25
The first case of balloon-occluded retrograde transvenous obliteration and partial splenic embolization for gastric varices in situs inversus abdominus. 61
33403531 2021
26
Endoscopic submucosal dissection for early esophageal and gastric neoplasia in decompensated cirrhosis with varices. 61
32757192 2021
27
Transcatheter embolization for stomal varices: A report of three patients. 61
33552329 2021
28
Clinical predictors for deep vein thrombosis on admission in patients with intertrochanteric fractures: a retrospective study. 61
33810786 2021
29
Therapeutic potential of flavonoids in the treatment of chronic venous insufficiency. 61
33278582 2021
30
FDA Approval Summary: Atezolizumab Plus Bevacizumab for the Treatment of Patients with Advanced Unresectable or Metastatic Hepatocellular Carcinoma. 61
33139264 2021
31
Clinical and novel application of FibroScan, FIB-4 and aspartate aminotransferase-to-platelet ratio index in liver fibrosis evaluation in patients with hepatocellular carcinoma and their roles in oesophageal variceal prediction. 61
33338308 2021
32
[Conservative treatment of varicose veins]. 61
33475812 2021
33
The recommended goal in the United Kingdom's National Institute for Health and Care Excellence Clinical Guideline 168 for immediate referral of patients with bleeding varicose veins is not being achieved. 61
32726670 2021
34
Outcomes after truncal ablation with or without concomitant phlebectomy for isolated symptomatic varicose veins (C2 disease). 61
32502731 2021
35
Systematic review of ambulatory selective variceal ablation under local anesthetic technique for the treatment of symptomatic varicose veins. 61
33137495 2021
36
Needs of standardisation in reporting a venous lower limb ultrasound exam for the assessment of varicose veins. 61
33673744 2021
37
Evaluation of physical activity level and exercise capacity in patients with varicose veins and chronic venous insufficiency. 61
33745365 2021
38
Early results of an Asian prospective multicenter VenaSeal real-world postmarket evaluation to investigate the efficacy and safety of cyanoacrylate endovenous ablation for varicose veins. 61
32387378 2021
39
Combined Lymphovenous Anastomosis and Great Saphenous Vein Stripping for Comorbid Lymphedema and Varicose Veins. 61
33794104 2021
40
Compression stockings attenuate the expression of proteins associated with vascular damage in human varicose veins. 61
32679199 2021
41
Kidney Transplant and Autosomal Recessive Polycystic Disease: A Case Report and Literature Review of 2 Brothers. 61
33736581 2021
42
In response to Letter to the Editor LT-21-132. 61
33687785 2021
43
COVID-19 in a Patient with Liver Cirrhosis. 61
33686051 2021
44
Artificial intelligence in precision medicine in hepatology. 61
33709606 2021
45
Portal hypertension in prolonged anorexia nervosa with laxative abuse: a case report with liver and kidney biopsy data. 61
32342271 2021
46
Direct oral anticoagulants and advanced liver disease: A systematic review and meta-analysis. 61
32895926 2021
47
Stepwise partial splenic embolization for portal hypertension based on a new concept: Splanchnic caput Medusae. 61
33408799 2021
48
Paroxysmal Nocturnal Hemoglobinuria: Case Report of a Rare Cause of Thrombosis in the Pediatric Age. 61
31842179 2021
49
Transjugular intrahepatic portosystemic shunt creation may be associated with hyperplastic hepatic nodular lesions in the long term: an analysis of 18 pediatric and young adult patients. 61
33783576 2021
50
Non-operative Treatment of Gastric Fistula after Splenectomy Combined with Pericardial Devascularisation in Portal Hypertension. 61
33775027 2021
Sources

Variations for Varicose Veins

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ClinVar genetic disease variations for Varicose Veins:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 ELN NM_000501.4(ELN):c.898A>T (p.Thr300Ser) SNV Uncertain significance 523433 rs766735416 GRCh37: 7:73466262-73466262
GRCh38: 7:74051932-74051932
Sources

Expression for Varicose Veins

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Search GEO for disease gene expression data for Varicose Veins.
Sources

Pathways for Varicose Veins

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Pathways related to Varicose Veins according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.01 VWF VEGFA TNF TIMP2 TIMP1 MMP9
2
Cytokine Signaling in Immune system 65
Show member pathways
 13.32 VWF VEGFA TNF TIMP1 MMP9 MMP3
3
Pathways in cancer 36
12.84 VEGFA MMP9 MMP2 MMP1 IL6 HIF1A
4
Degradation of the extracellular matrix 65
Show member pathways
 12.73 TIMP2 TIMP1 MMP9 MMP3 MMP2 MMP1
5
Immune response IL-23 signaling pathway 23
Show member pathways
 12.58 TNF TIMP1 MMP2 IL6 F2
6
IL-17 Family Signaling Pathways 64
Show member pathways
 12.34 TNF MMP9 MMP3 MMP1 IL6
7
Selenium Micronutrient Network 1
Show member pathways
 12.31 TNF MTHFR IL6 F2
8
Proteoglycans in cancer 36
12.3 VEGFA TNF MMP9 MMP2 HIF1A
9
G-protein signaling Ras family GTPases in kinase cascades (scheme) 23
Show member pathways
 12.29 VEGFA TIMP1 MMP3 MMP1 HIF1A
10
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.17 VEGFA TNF IL6 HIF1A
11
Colorectal Cancer Metastasis 63
12.13 VEGFA TNF MMP9 MMP2 MMP1 IL6
12
Fluid shear stress and atherosclerosis 36
12.09 VEGFA TNF MMP9 MMP2
13
Adipogenesis 1
12.06 TNF IL6 HIF1A FOXC2
14
TNF signaling pathway 36
11.98 TNF MMP9 MMP3 IL6
15
HIF-1 signaling pathway 36
11.96 VEGFA TIMP1 IL6 HIF1A
16
AGE-RAGE signaling pathway in diabetic complications 36
11.92 VEGFA TNF MMP2 IL6
17
Rheumatoid arthritis 36
11.86 VEGFA TNF MMP3 MMP1 IL6
18
Matrix Metalloproteinases 1
Show member pathways
 11.8 TNF TIMP2 TIMP1 MMP9 MMP3 MMP2
19
Bladder cancer 36 1
11.75 VEGFA MMP9 MMP2 MMP1
20
AGE/RAGE pathway 1
11.66 MMP9 MMP2 HIF1A
21
LPA receptor mediated events 1
11.65 MMP9 MMP2 IL6
22
Angiogenesis (CST) 4
11.65 VWF TIMP2 TIMP1 MMP9 MMP3 MMP2
23
Lung fibrosis 1
11.64 TNF TIMP1 MMP9 MMP2 IL6 ELN
24
Cell adhesion_ECM remodeling 23
11.58 TIMP2 TIMP1 MMP9 MMP3 MMP2 MMP1
25
Hepatitis C and Hepatocellular Carcinoma 1
11.57 VEGFA MMP1 IL6 HIF1A
26
Photodynamic therapy-induced AP-1 survival signaling. 1
11.55 TNF MMP2 IL6
27
amb2 Integrin signaling 1
11.53 TNF MMP9 MMP2 IL6
28
Interleukin-10 signaling 65
11.52 TNF TIMP1 IL6
29
Cell adhesion_Cell-matrix glycoconjugates 23
11.39 TIMP2 MMP9 MMP3 MMP1 ELN
30
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.36 MMP9 MMP2 MMP1 IL6
31
Interleukin-4 and 13 signaling 65
11.33 VEGFA TNF TIMP1 MMP9 MMP3 MMP2
32
Antifolate resistance 36
11.31 TNF MTHFR IL6
33
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.3 VEGFA TNF MMP9 MMP3 MMP2 MMP1
34
Development_Leptin signaling via JAK/STAT and MAPK cascades 23
Show member pathways
 11.29 VEGFA TIMP1 HIF1A
35
IL1 and megakaryocytes in obesity 1
11.18 TIMP2 TIMP1 MMP9 F2
36
Angiogenesis (WikiPathways) 1
11.14 VEGFA TIMP2 MMP9 HIF1A
37
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 65
11.11 MMP2 MMP1 F2
38
Immune response_Oncostatin M signaling via JAK-Stat in human cells 23
11.05 VEGFA TIMP1 MMP1
39
miR-148a/miR-31/FIH1/HIF1andalpha;-Notch signaling in glioblastoma 1
10.63 VEGFA HIF1A
Sources

GO Terms for Varicose Veins

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Cellular components related to Varicose Veins according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10 VWF VEGFA TNF TIMP2 TIMP1 SERPINC1
2 extracellular region GO:0005576 9.83 VWF VEGFA TNF TIMP2 TIMP1 SHBG
3 collagen-containing extracellular matrix GO:0062023 9.7 VWF TIMP2 SERPINC1 MMP9 MMP2 F2
4 platelet alpha granule lumen GO:0031093 9.5 VWF VEGFA TIMP1
5 extracellular matrix GO:0031012 9.28 VWF VEGFA TIMP2 TIMP1 MMP9 MMP3

Biological processes related to Varicose Veins according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.91 VEGFA TNF MMP9 F2
2 leukocyte migration GO:0050900 9.91 TNF MMP9 MMP1 F2
3 response to hypoxia GO:0001666 9.87 VEGFA MTHFR MMP2 HIF1A
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.81 VEGFA TNF IL6
5 positive regulation of endothelial cell proliferation GO:0001938 9.81 VEGFA HIF1A AGGF1
6 cellular protein metabolic process GO:0044267 9.8 TIMP1 SERPINC1 MMP2 MMP1 IL6 F2
7 extracellular matrix organization GO:0030198 9.8 VWF TNF MMP9 MMP3 MMP2 MMP1
8 positive regulation of smooth muscle cell proliferation GO:0048661 9.77 TNF MMP2 IL6
9 response to hormone GO:0009725 9.77 TIMP2 TIMP1 FOXC2
10 positive regulation of protein complex assembly GO:0031334 9.76 VEGFA TNF MMP3 MMP1
11 hemostasis GO:0007599 9.75 VWF SERPINC1 F2
12 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.73 TNF MMP9 MMP2
13 outflow tract morphogenesis GO:0003151 9.72 VEGFA HIF1A ELN
14 collagen catabolic process GO:0030574 9.71 MMP9 MMP3 MMP2 MMP1
15 lactation GO:0007595 9.7 VEGFA SERPINC1 HIF1A
16 positive regulation of chemokine production GO:0032722 9.69 TNF IL6 HIF1A
17 positive regulation of JAK-STAT cascade GO:0046427 9.67 TNF IL6 F2
18 response to amyloid-beta GO:1904645 9.65 MMP9 MMP3 MMP2
19 negative regulation of lipid storage GO:0010888 9.63 TNF IL6
20 extracellular matrix disassembly GO:0022617 9.63 TIMP2 TIMP1 MMP9 MMP3 MMP2 MMP1
21 negative regulation of metallopeptidase activity GO:1905049 9.62 TIMP2 TIMP1
22 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.62 TIMP2 TIMP1
23 regulation of neuroinflammatory response GO:0150077 9.61 MMP9 MMP3 IL6
24 cytokine-mediated signaling pathway GO:0019221 9.61 VEGFA TNF TIMP1 MMP9 MMP3 MMP2
25 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.58 VEGFA HIF1A
26 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.54 TIMP1 HIF1A
27 vascular endothelial growth factor production GO:0010573 9.54 TNF IL6 HIF1A
28 cellular response to UV-A GO:0071492 9.02 TIMP1 MMP9 MMP3 MMP2 MMP1

Molecular functions related to Varicose Veins according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.91 TIMP2 TIMP1 MMP9 MMP3 MMP2 MMP1
2 cytokine activity GO:0005125 9.71 VEGFA TNF TIMP1 IL6
3 metallopeptidase activity GO:0008237 9.67 MMP9 MMP3 MMP2 MMP1
4 growth factor activity GO:0008083 9.62 VEGFA TIMP1 IL6 F2
5 metalloendopeptidase activity GO:0004222 9.56 MMP9 MMP3 MMP2 MMP1
6 endopeptidase activity GO:0004175 9.46 MMP9 MMP3 MMP2 MMP1
7 serine-type endopeptidase activity GO:0004252 9.35 MMP9 MMP3 MMP2 MMP1 F2
8 protease binding GO:0002020 9.02 VWF TNF TIMP2 TIMP1 SERPINC1
Sources

Sources for Varicose Veins

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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