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MCID: VRC005
MIFTS: 64

Varicose Veins

Categories: Cardiovascular diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Varicose Veins

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MalaCards integrated aliases for Varicose Veins:

Name: Varicose Veins 57 12 29 6 43 44 15 63 63
Venous Ectasia 12
Venous Varices 12
Varicosity 73
Varices 12
Varix 12

Characteristics:

OMIM:

57
Inheritance:
multifactorial vs. autosomal or x-linked dominant


Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)


External Ids:

OMIM 57 192200
Disease Ontology 12 DOID:799
ICD10 33 I83.90
MeSH 44 D014648
NCIt 50 C35114
MedGen 42 C0042345
UMLS 73 C0042345
Sources

Summaries for Varicose Veins

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MedlinePlus : 43 Varicose veins are swollen, twisted veins that you can see just under the skin. They usually occur in the legs, but also can form in other parts of the body. Hemorrhoids are a type of varicose vein. Your veins have one-way valves that help keep blood flowing toward your heart. If the valves are weak or damaged, blood can back up and pool in your veins. This causes the veins to swell, which can lead to varicose veins. Varicose veins are very common. You are more at risk if you are older, are female, have obesity, don't exercise, or have a family history of varicose veins. They can also be more common in pregnancy. Doctors often diagnose varicose veins from a physical exam. Sometimes you may need additional tests. Exercising, losing weight, elevating your legs when resting, and not crossing them when sitting can help keep varicose veins from getting worse. Wearing loose clothing and avoiding long periods of standing can also help. If varicose veins are painful or you don't like the way they look, your doctor may recommend procedures to remove them. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Varicose Veins, also known as venous ectasia, is related to chronic venous insufficiency and budd-chiari syndrome, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Varicose Veins is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Integrin Pathway and Cytokine Signaling in Immune system. The drugs Propranolol and Carvedilol have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and testes, and related phenotypes are varicose veins and Reduced mammosphere formation

Disease Ontology : 12 A vein disease that is characterized by swollen, twisted veins visible just under the surface of the skin.

PubMed Health : 63 About varicose veins: Varicose (VAR-i-kos) veins are swollen, twisted veins that you can see just under the surface of the skin. These veins usually occur in the legs, but they also can form in other parts of the body.Varicose veins are a common condition. They usually cause few signs and symptoms. Sometimes varicose veins cause mild to moderate pain, blood clots, skin ulcers (sores), or other problems.

Wikipedia : 76 Varicose veins are veins that have become enlarged and twisted. The term commonly refers to the veins on... more...

Description from OMIM: 192200
Sources

Related Diseases for Varicose Veins

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Diseases related to Varicose Veins via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 240)
# Related Disease Score Top Affiliating Genes
1 chronic venous insufficiency 31.6 MMP1 MMP9 TIMP1
2 budd-chiari syndrome 31.5 F2 F5 MTHFR SERPINC1
3 venous insufficiency 30.9 F2 MMP1 MMP9 TIMP1 VWF
4 vein disease 30.6 F2 F5 MTHFR SERPINC1
5 thrombophlebitis 30.5 F2 F5 MTHFR SERPINC1
6 post-thrombotic syndrome 30.4 F2 F5 SERPINC1
7 von willebrand's disease 30.3 F2 F5 VWF
8 thrombosis 29.8 F2 F5 MTHFR SERPINC1 VWF
9 sudden sensorineural hearing loss 29.7 F2 F5 MTHFR SERPINC1
10 pulmonary embolism 29.6 F2 F5 MTHFR SERPINC1
11 thrombophilia due to thrombin defect 29.4 F2 F5 MTHFR SERPINC1 VWF
12 thrombophilia 29.4 F2 F5 MTHFR SERPINC1 VWF
13 arteries, anomalies of 28.6 F2 MMP9 MTHFR SERPINC1 VEGFA VWF
14 vascular disease 27.2 ELN F2 F5 MMP9 MTHFR SERPINC1
15 myocardial infarction 26.1 F2 F5 HIF1A MMP2 MMP3 MMP9
16 orbital varix 12.4
17 esophageal varix 12.2
18 varicocele 11.7
19 klippel-trenaunay-weber syndrome 11.5
20 lymphedema-distichiasis syndrome 11.3
21 hydrops fetalis, nonimmune, and/or atrial septal defect 11.2
22 rheumatoid nodulosis 11.0 MMP3 MMP9
23 cutis marmorata telangiectatica congenita 11.0
24 hepatic fibrosis, severe due to schistosoma mansoni infection 11.0
25 liposarcoma 11.0
26 superior limbic keratoconjunctivitis 11.0 MMP1 MMP3
27 extracranial arteriovenous malformation 11.0 MMP2 MMP9
28 autoimmune inner ear disease 10.9 MMP9 TIMP1
29 lentigo maligna melanoma 10.9 MMP2 MMP9
30 paracetamol poisoning 10.9 F2 F5
31 gingival hypertrophy 10.9 MMP3 MMP9 TIMP2
32 corneal ulcer 10.8 MMP2 MMP3 MMP9
33 nodular malignant melanoma 10.8 MMP1 MMP2 TIMP2
34 villous adenocarcinoma 10.8 MMP2 MMP9
35 hypertensive heart disease 10.8 MMP1 MMP2 MMP9
36 chronic venous leg ulcers 10.8 MMP9 TIMP1
37 diabetic foot ulcers 10.8 MMP9 TIMP1
38 hepatoportal sclerosis 10.8 ELN F2
39 inferior vena cava interruption 10.8 F5 MTHFR
40 conjunctival nevus 10.8 MMP2 MMP9 TIMP1
41 lung giant cell carcinoma 10.8 MMP2 MMP9 TIMP1
42 chronic actinic dermatitis 10.7 ELN MMP1 MMP9
43 al amyloidosis 10.7 MMP1 VWF
44 tendinosis 10.7 MMP1 MMP3 TIMP1
45 carotid artery disease 10.7 MMP1 MMP9 TIMP1
46 bone deterioration disease 10.7 MMP1 MMP3 TIMP1
47 psammomatous meningioma 10.7 MMP2 MMP9
48 spinal stenosis 10.7 MMP3 TIMP1 TIMP2
49 gingival overgrowth 10.7 MMP1 MMP3 TIMP1
50 carotid stenosis 10.7 MMP1 MMP9 MTHFR

Graphical network of the top 20 diseases related to Varicose Veins:



Diseases related to Varicose Veins
Sources

Symptoms & Phenotypes for Varicose Veins

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Symptoms via clinical synopsis from OMIM:

57
Vascular:
varicose veins

Misc:
twice as frequent in females as in males


Clinical features from OMIM:

192200

Human phenotypes related to Varicose Veins:

32
# Description HPO Frequency HPO Source Accession
1 varicose veins 32 HP:0002619

UMLS symptoms related to Varicose Veins:


angina pectoris, chest pain, edema

GenomeRNAi Phenotypes related to Varicose Veins according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 COL3A1 FOXC2 MMP2 MMP7 SERPINC1 TIMP1

MGI Mouse Phenotypes related to Varicose Veins:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.34 MMP2 F5 FOXC2 AGGF1 HIF1A COL3A1
2 homeostasis/metabolism MP:0005376 10.34 MMP1 MMP2 F5 FOXC2 HIF1A COL3A1
3 immune system MP:0005387 10.25 MMP1 MMP2 FOXC2 HIF1A COL3A1 F2
4 mortality/aging MP:0010768 10.21 F2 F5 MMP2 FOXC2 AGGF1 COL3A1
5 hematopoietic system MP:0005397 10.2 F2 MMP2 HIF1A VWF VEGFA TIMP2
6 digestive/alimentary MP:0005381 10.08 F2 FOXC2 COL3A1 HIF1A VWF VEGFA
7 nervous system MP:0003631 10.07 MMP2 F5 FOXC2 AGGF1 HIF1A F2
8 neoplasm MP:0002006 9.92 MMP1 MMP2 AGGF1 HIF1A MMP9 VEGFA
9 respiratory system MP:0005388 9.81 F2 MMP2 FOXC2 AGGF1 COL3A1 HIF1A
10 skeleton MP:0005390 9.61 F2 MMP2 FOXC2 HIF1A VEGFA TIMP1
11 vision/eye MP:0005391 9.23 FOXC2 HIF1A VEGFA MMP9 MMP2 MTHFR
Sources

Drugs & Therapeutics for Varicose Veins

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PubMedHealth treatment related to Varicose Veins: 63

Varicose veins are treated with lifestyle changes and medical procedures. The goals of treatment are to relieve symptoms, prevent complications, and improve appearance.If varicose veins cause few symptoms, your doctor may simply suggest making lifestyle changes. If your symptoms are more severe, your doctor may recommend one or more medical procedures. For example, you may need a medical procedure if you have a lot of pain, blood clots, or skin disorders caused by your varicose veins.Some people who have varicose veins choose to have procedures to improve how their veins look.Although treatment can help existing varicose veins, it can't keep new varicose veins from forming.

Drugs for Varicose Veins (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 293)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propranolol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 525-66-6 4946
2
Carvedilol Approved, Investigational Phase 4,Phase 3,Not Applicable 72956-09-3 2585
3
Nadolol Approved Phase 4,Phase 3,Not Applicable 42200-33-9 39147
4
Epinephrine Approved, Vet_approved Phase 4,Not Applicable 51-43-4 5816
5
Racepinephrine Approved Phase 4,Not Applicable 329-65-7 838
6
AT-101 Approved, Investigational Phase 4 90141-22-3, 652-67-5 12597
7
Isosorbide Dinitrate Approved, Investigational Phase 4 87-33-2 6883
8
Nitric Oxide Approved Phase 4,Phase 3,Phase 2 10102-43-9 145068 160954
9
Prazosin Approved Phase 4 19216-56-9 4893
10
Simvastatin Approved Phase 4,Phase 3,Not Applicable 79902-63-9 54454
11
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
12
Losartan Approved Phase 4 114798-26-4 3961
13
Esomeprazole Approved, Investigational Phase 4,Not Applicable 161796-78-7, 119141-88-7 4594 9579578
14
Polidocanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9002-92-0
15
Ethiodized oil Approved, Investigational Phase 4,Phase 3,Not Applicable 8008-53-5
16
Octreotide Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 83150-76-9 383414 6400441
17
Terlipressin Approved, Investigational Phase 4,Phase 3,Not Applicable 14636-12-5 72081
18
Somatostatin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 38916-34-6, 51110-01-1 53481605
19
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
20
Entecavir Approved, Investigational Phase 4,Phase 1,Phase 2 142217-69-4 153941
21
Alginic acid Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 9005-32-7
22
Thrombin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable
23
ethanolamine oleate Approved Phase 4,Phase 3 2272-11-9
24
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
25
Ceftriaxone Approved Phase 4,Not Applicable 73384-59-5 5479530 5361919
26
Colchicine Approved Phase 4 64-86-8 6167 2833
27
Peginterferon alfa-2b Approved Phase 4,Phase 3 99210-65-8, 215647-85-1
28
Pantoprazole Approved Phase 4 102625-70-7 4679
29
Petrolatum Approved, Investigational Phase 4,Phase 2,Not Applicable 8009-03-8
30
Sodium Tetradecyl Sulfate Approved, Investigational Phase 4,Not Applicable 1191-50-0, 139-88-8 14492 5248
31
Menthol Approved Phase 4,Phase 3,Not Applicable 2216-51-5 16666
32
Tranexamic Acid Approved Phase 4 1197-18-8 5526
33
Coal tar Approved Phase 4,Not Applicable 8007-45-2
34
Telbivudine Approved, Investigational Phase 4 3424-98-4 159269
35
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 11103-57-4, 68-26-8 445354
36 Adrenergic Agents Phase 4,Phase 3,Phase 2,Not Applicable
37 Adrenergic Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
38 Adrenergic beta-Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
39 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2,Not Applicable
40 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Not Applicable
41 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Vasodilator Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Adrenergic alpha-1 Receptor Antagonists Phase 4,Phase 3,Not Applicable
44 Adrenergic alpha-Antagonists Phase 4,Phase 3,Not Applicable
45 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Adrenergic Agonists Phase 4
47 Adrenergic alpha-Agonists Phase 4
48 Adrenergic beta-Agonists Phase 4
49 Anti-Asthmatic Agents Phase 4,Phase 2
50 Autonomic Agents Phase 4,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 550)
# Name Status NCT ID Phase Drugs
1 Preventing Recurrent Bleeding After Eradication of Esophageal Varices Unknown status NCT02740166 Phase 4 propranolol
2 Early Feeding Following Ligation of Acute Bleeding Varices Unknown status NCT01287702 Phase 4
3 Primary Prevention of Patients With Hepatocellular Carcinoma and Concomitant Esophageal Varices Unknown status NCT01970748 Phase 4 Propranolol
4 The Effect of Carvedilol Vs Propranolol in Cirrhotic Patients With Variceal Bleeding Unknown status NCT02385422 Phase 4 Carvedilol;Propranolol
5 Endoscopic Treatment Alone Versus Combined Propranolol and Endoscopic Treatment of Acute Variceal Hemorrhage in Patients With Hepatocellular Carcinoma Unknown status NCT01451658 Phase 4 propranolol
6 Primary Prevention of Gastric Variceal Bleeding : Endoscopic Treatment Versus Non-selective Beta-blocker Unknown status NCT01298271 Phase 4 propranolol
7 Banding Ligation With Carvedilol Versus Carvedilol for the Prevention of First Bleeding Unknown status NCT01383044 Phase 4 carvedilol
8 Compression Aided Management of Edema in Patients With C3 Venous Disease Unknown status NCT00766974 Phase 4
9 Fluid Infusion During Breast Surgery Unknown status NCT00431743 Phase 4 Hydroxyethylstarch 130/0,4;Lactated Ringer's solution
10 RCT of Carvedilol Versus Variceal Band Ligation in the Primary Prophylaxis of Oesophageal Variceal Haemorrhage Unknown status NCT01070641 Phase 4 Carvedilol
11 Trial of Hemospray Plus Epinephrine Injection Versus Endoscopic Hemoclip Unknown status NCT02537353 Phase 4 Hemospray;Adrenaline
12 Treatment for Prevention of Variceal Rebleeding Guided by the Hemodynamic Response Unknown status NCT00563602 Phase 4
13 Hemodynamic Effect of Simvastatin With Beta Blockers in Clinical Portal Hypertension Unknown status NCT01282385 Phase 4 Simvastatin;placebo
14 Prevention of Decompensation in Liver Cirrhosis Unknown status NCT00239096 Phase 4 losartan (drug)
15 Long-term Oral Esomeprazole for Prevention of Peptic Ulcer Rebleeding in High-risk Patients Unknown status NCT02456012 Phase 4 oral esomeprazole 20 mg twice daily;oral esomeprazole 20 mg once daily
16 A Study Of Pain And Quality Of Life Outcomes In Subjects With a Single Painful Venous Leg Ulcer Treated With Apligraf® Unknown status NCT02011724 Phase 4
17 Clinical Evaluation of the SNaP Wound Care System Unknown status NCT01113658 Phase 4
18 PROPRANOLOL PLUS LIGATION REDUCES RECURRENCE OF ESOPHAGEAL VARICES? Completed NCT01893541 Phase 4 PROPRANOLOL
19 Efficacy and Safety of Esarin Gel in Chronic Venous Insufficiency and Varicose Veins Completed NCT02346058 Phase 4 Esarin Gel
20 COMFORT: A Multicenter, Open-label, Randomized, Crossover Study Completed NCT02462720 Phase 4 Varithena®
21 Carvedilol as an Adjunct to Endoscopic Cyanoacrylate Injection for Secondary Prophylaxis of Gastric Variceal Bleeding Completed NCT02504723 Phase 4 carvedilol;cyanoacrylate
22 Time Interval for Endoscopic Variceal Ligation Completed NCT01291277 Phase 4
23 Surgery Versus Sclerotherapy for Isolated Accessory Great Saphenous Vein Varicosis Completed NCT02010723 Phase 4 sclerotherapy with aethoxysclerol foam
24 Study Protocol Comparing Polidocanol Versus Hypertonic Glucose for Treatment of Reticular Veins Completed NCT02054325 Phase 4 Polidocanol with Glucose;Glucose
25 A Randomized Controlled Trial Comparing Band Ligation and Cyanoacrylate Injection for Esophageal Varices Completed NCT00799851 Phase 4 cyanoacrylate injection
26 Hemodynamic Effects of Terlipressin and High Dose Octreotide Completed NCT02119884 Phase 4 Terlipressin;Octreotide
27 A Trial of Ligation Plus Nadolol Versus Nadolol Alone in the Prophylaxis of First Variceal Bleeding in Cirrhosis Completed NCT00921349 Phase 4 Nadolol
28 Polidocanol Versus Glucose Treatment of Telangiectasia Trial Completed NCT02657252 Phase 4 Glucose;Polidocanol with Glucose
29 Painless Local Infiltration Anesthesia Completed NCT01611324 Phase 4 Mepivacaine chlorhydrate 2% in Sodium Bicarbonate 1.4%;Mepivacaine chlorhydrate 2% with epinephrine in NS 0.9%
30 EVL (Endoscopic Variceal Ligation) Plus Vasoconstrictor vs.Ligation Plus PPI( Proton Pump Inhibitor) in the Control of Acute Esophageal Variceal Bleeding Completed NCT01112852 Phase 4 pantoloc 40 mg;somatostatin or terlipressin
31 Comparison of 3 Days and 7 Days Intravenous Ceftriaxone Prophylaxis for Variceal Bleeding Completed NCT00838864 Phase 4 ceftrioxone;ceftrioxone
32 Study on B-blockers to Prevent Decompensation of Cirrhosis With HTPortal Completed NCT01059396 Phase 4 propranolol;carvedilol;placebo
33 Comparison of Endoscopic Injection of Conventional and Double Doses Cyanoacrylate for Gastric Variceal Hemorrhage Completed NCT00735358 Phase 4
34 ClosureFAST vs. Laser Ablation for the Treatment of GSV Disease: A Multicenter, Single-Blinded, Randomized Study. Completed NCT00509392 Phase 4
35 The Safety & Efficacy of Terlipressin vs Octreotide for the Control of Variceal Bleed Completed NCT00534677 Phase 4 Terlipressin;Octreotide
36 A Trial of Nadolol Plus Isosorbide Mononitrate Versus Carvedilol for the Prevention of Variceal Rebleeding Completed NCT01103154 Phase 4 carvedilol;nadolol + ISMN
37 Comparison of Terlipressin, Somatostatin, and Octreotide for Control of Variceal Bleeding Completed NCT00966355 Phase 4 Terlipressin;Somatostatin;Octreotide
38 Short Course Terlipressin for Control of Acute Variceal Bleeding Completed NCT00369694 Phase 4 Terlipressin;Terlipressin & then Dummy
39 Radiofrequency Ablation vs. Laser Ablation of the Incompetent Small Saphenous Vein Completed NCT02248740 Phase 4
40 Radiofrequency Ablation vs Laser Ablation of the Incompetent Greater Saphenous Vein Completed NCT02236338 Phase 4
41 Peripheral Vascular Disease and Nerve Stimulation Completed NCT01942941 Phase 4
42 Secondary Prophylaxis After Variceal Bleeding in Non-Responders Completed NCT00450164 Phase 4 Nadolol;Isosorbide mononitrate;Prazosin
43 Band Ligation Versus Transjugular Intrahepatic Portosystemic Stent Shunt (TIPS) in Cirrhotics With Recurrent Variceal Bleeding Non Responding to Medical Therapy Completed NCT00570973 Phase 4
44 Study of Long-term Peg Intron vs. Colchicine in Non-responders. Completed NCT00179413 Phase 4 PEG -Intron;Colchicine
45 Vasoactive Drugs in Real World Practice Completed NCT02757703 Phase 4 Somatostatin;Terlipressin;Pantoprazole
46 A Pilot Trial of the Use of ReCell® Autologous Cell Harvesting Device for Venous Leg Ulcers Completed NCT01743053 Phase 4
47 Trial on the Efficacy of Prontosan Wound Irrigation Solution and Prontosan Wound Gel Completed NCT01153633 Phase 4
48 Neuromuscular Electrical Therapy in Venous Ulcers Completed NCT01372020 Phase 4
49 Evaluation of Pain Associated With the Removal of Wound Dressing During Care of Venous Leg Ulcer. Comparison of the Efficacy and Safety of Two Dressings Urgotul and TulleGras Completed NCT02104180 Phase 4
50 Clinical Trial to Evaluate the Efficacy, Tolerance and Acceptability of URGO Dressing vs a Hydrofibre in the Local Management of Venous or Predominantly Venous Mixed Leg Ulcers. Completed NCT01449422 Phase 4

Search NIH Clinical Center for Varicose Veins

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: varicose veins

Sources

Genetic Tests for Varicose Veins

About this section

Genetic tests related to Varicose Veins:

# Genetic test Affiliating Genes
1 Varicose Veins 29
Sources

Anatomical Context for Varicose Veins

About this section

MalaCards organs/tissues related to Varicose Veins:

41
Liver, Skin, Testes, Heart, Lung, Skeletal Muscle, Spleen
Sources

Publications for Varicose Veins

About this section

Articles related to Varicose Veins:

(show top 50) (show all 812)
# Title Authors Year
1
The influence of age on valve disease in patients with varicose veins analysed by transmission electron microscopy and stereology. ( 29808768 )
2018
2
Five-year follow-up of a randomized clinical trial comparing open surgery, foam sclerotherapy and endovenous laser ablation for great saphenous varicose veins. ( 29652086 )
2018
3
A national survey on management of varicose veins in China. ( 29439933 )
2018
4
Presence of Varicose Veins is the Most Important Risk Factor for Developing PTS. ( 29966166 )
2018
5
Treating great and small saphenous vein insufficiency with histoacryl in patients with symptomatic varicose veins and increased risk of surgery. ( 29890917 )
2018
6
Endovenous Treatment of Varicose Veins in Patients With Pyoderma Gangrenosum. ( 29933301 )
2018
7
Ecchymosis: A novel sign in patients with varicose veins. ( 29660929 )
2018
8
Prospective comparison of effect of ligation and foam sclerotherapy with foam sclerotherapy alone for varicose veins. ( 29428536 )
2018
9
Polymorphisms in inflammation-related genes and the risk of primary varicose veins in ethnic Russians. ( 29247331 )
2018
10
Surgical treatment of recurrent varicose veins in the lower limbs associated with endovascular treatment of iliac vein stenosis. ( 29337179 )
2018
11
Systematic review and meta-analysis of endovascular and surgical revascularization for patients with chronic lower extremity venous insufficiency and varicose veins. ( 29421005 )
2018
12
A Comparison of Concomitant Tributary Laser Ablation and Foam Sclerotherapy in Patients Undergoing Truncal Endovenous Laser Ablation for Lower Limb Varicose Veins. ( 29705225 )
2018
13
Acute Effects of Graduated Elastic Compression Stockings in Patients with Symptomatic Varicose Veins: A Randomised Double Blind Placebo Controlled Trial. ( 29129457 )
2018
14
Polymorphisms of genes involved in inflammation and blood vessel development influence the risk of varicose veins. ( 29660117 )
2018
15
A leg ulcer with pulsating varicose veins - from the legs to the heart. ( 29115044 )
2018
16
ClariVeina8c - One year results of mechano-chemical ablation for varicose veins in a multi-ethnic Asian population from Singapore. ( 29690839 )
2018
17
Endovenous Thermal Ablation of Recurrent Varicose Veins due to Residual Great Saphenous Venous Insufficiency After Saphenous Venous Surgery: A Comparative Study. ( 29781902 )
2018
18
Compression with 23a88mmHg or 35a88mmHg stockings after saphenous catheter foam sclerotherapy and phlebectomy of varicose veins: A randomized controlled study. ( 29754530 )
2018
19
A 1470-nm laser combined with foam sclerotherapy in day surgery: a better choice for lower limb varicose veins. ( 29687409 )
2018
20
Varicose Veins and Lower Extremity Venous Insufficiency. ( 29628617 )
2018
21
Haemorrhage from varicose veins and varicose ulceration: A systematic review. ( 29808553 )
2018
22
Re: "Catheter Foam Sclerotherapy of the Great Saphenous Vein, with Peri-saphenous Tumescence Infiltration and Saphenous Irrigation"-Is Modified Catheter Foam Sclerotherapy a Step Back in the Evolution of Endovenous Ablation for Varicose Veins? ( 29246435 )
2018
23
Compression therapy for uncomplicated varicose veins - Too little for too much? ( 29954256 )
2018
24
Prospective, double-blind, randomized controlled trial comparing electrocoagulation and radiofrequency in theA treatment of patients with great saphenous vein insufficiency and lower limb varicose veins. ( 29229466 )
2018
25
Endovenous Management of Varicose Veins. ( 29874921 )
2018
26
Symptomatic recurrent varicose veins due to primary avalvular varicose anomalies (PAVA): A previously unreported cause of recurrence. ( 29796272 )
2018
27
Commentary on pelvic venous reflux in males with varicose veins and recurrent varicose veins. ( 29431010 )
2018
28
The haemodynamic causes of skin changes in limbs with primary varicose veins. ( 29726741 )
2018
29
The role of compression after endovenous ablation of varicose veins. ( 29680439 )
2018
30
Systematic review and meta-analysis of randomized controlled trials evaluating long-term outcomes of endovenous management of lowerA extremity varicose veins. ( 29292115 )
2018
31
Early clinical experience using telemedicine for the management of patients with varicose vein disease. ( 28969485 )
2017
32
Commentary on the article "A prospective study of a vein sparing technique for the management of varicose vein disease" by M Zmudzinski etA al. ( 29122236 )
2017
33
Varicose Veins ( 29262112 )
2017
34
Treatment of foot varicose veins: A study of 119 consecutive patients. ( 28447531 )
2017
35
Anatomic variations of lower extremity venous system in varicose vein patients: demonstration by three-dimensional CT venography. ( 27565630 )
2017
36
Patient-perceived outcomes of different anaesthetic techniques in classical surgical treatment of varicose veins of lower limbs. ( 29339589 )
2017
37
Relationship between patient-reported symptoms, limitations in daily activities, and psychological impact in varicose veins. ( 28214491 )
2017
38
Recurrent residual or progressive varicose veins: postoperative long term follow-up of 353 patients. ( 29339588 )
2017
39
Erythrocytes properties in varicose veins patients. ( 28012884 )
2017
40
[Endovenous thermal interventions in treatment of patients with lower limb varicose veins]. ( 28902831 )
2017
41
Functional polymorphism rs1024611 in the MCP1 gene is associated with the risk of varicose veins of lower extremities. ( 28623996 )
2017
42
Outdoor Life During Summer in Russia: Varicose Veins Don't Stand a Chance! ( 29097013 )
2017
43
CHIVA - A prospective study of a vein sparing technique for the management of varicose vein disease. ( 28431588 )
2017
44
Percutaneous treatment with radiofrequency ablation of varicose veins recurring after vein stripping surgery A preliminary study. ( 29197190 )
2017
45
Fifteen Year Results of Radiofrequency Ablation, Using VNUS Closure, for the Abolition of Truncal Venous Reflux in Patients with Varicose Veins. ( 28697961 )
2017
46
Evaluation of Plasma Growth Factors (VEGF, PDGF, EGF, ANG1, and ANG2) in Patients with Varicose Veins Before and After Treatment with Endovenous Laser Ablation. ( 29173075 )
2017
47
Oxidative Stress And Prolidase Enzyme Activity In The Pathogenesis Of Primary Varicose Veins. ( 29216795 )
2017
48
Association between itching and the serum zinc levels in patients with varicose veins. ( 28944076 )
2017
49
A multicenter, randomized, placebo-controlled study to evaluate the efficacy and safety of VarithenaAr (polidocanol endovenous microfoam 1%) for symptomatic, visible varicose veins with saphenofemoral junction incompetence. ( 27013511 )
2017
50
Clinical Outcomes of Radiofrequency Ablation for Unilateral and Bilateral Varicose Veins. ( 28902027 )
2017
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Variations for Varicose Veins

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ClinVar genetic disease variations for Varicose Veins:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ELN NM_001278939.1(ELN): c.898A> T (p.Thr300Ser) single nucleotide variant Uncertain significance rs766735416 GRCh37 Chromosome 7, 73466262: 73466262
2 ELN NM_001278939.1(ELN): c.898A> T (p.Thr300Ser) single nucleotide variant Uncertain significance rs766735416 GRCh38 Chromosome 7, 74051932: 74051932
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Expression for Varicose Veins

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Search GEO for disease gene expression data for Varicose Veins.
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Pathways for Varicose Veins

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Pathways related to Varicose Veins according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Integrin Pathway 64
Show member pathways
 13.37 COL3A1 ELN F2 MMP1 MMP2 MMP3
2
Cytokine Signaling in Immune system 66
Show member pathways
 13.32 HIF1A MMP1 MMP2 MMP3 MMP9 TIMP1
3
Response to elevated platelet cytosolic Ca2+ 66
Show member pathways
 13.26 F2 F5 MMP1 SERPINC1 TIMP1 VEGFA
4
Pathways in cancer 37
12.77 HIF1A MMP1 MMP2 MMP9 VEGFA
5
Collagen chain trimerization 66
Show member pathways
 12.76 COL3A1 ELN F2 F5 MMP3 MMP7
6
Degradation of the extracellular matrix 66
Show member pathways
 12.63 COL3A1 ELN MMP1 MMP2 MMP3 MMP7
7
Proteoglycans in cancer 37
12.24 HIF1A MMP2 MMP9 VEGFA
8
G-protein signaling Ras family GTPases in kinase cascades (scheme) 22
Show member pathways
 12.15 HIF1A MMP1 MMP3 TIMP1 VEGFA
9
Colorectal Cancer Metastasis 64
12.13 MMP1 MMP2 MMP7 MMP9 VEGFA
10
Formation of Fibrin Clot (Clotting Cascade) 66
Show member pathways
 12.12 F2 F5 SERPINC1 VWF
11
Complement and coagulation cascades 1 37
12.06 F2 F5 SERPINC1 VWF
12
Interleukin-4 and 13 signaling 66
11.86 HIF1A MMP1 MMP2 MMP3 MMP9 TIMP1
13
HIF-1 signaling pathway 37
11.83 HIF1A TIMP1 VEGFA
14
AGE-RAGE signaling pathway in diabetic complications 37
11.83 COL3A1 MMP2 VEGFA
15
Rheumatoid arthritis 37
11.78 MMP1 MMP3 VEGFA
16
Bladder cancer 37 1
11.71 MMP1 MMP2 MMP9 VEGFA
17
Matrix Metalloproteinases 1
Show member pathways
 11.7 MMP1 MMP2 MMP3 MMP7 MMP9 TIMP1
18
AGE/RAGE pathway 1
11.66 HIF1A MMP2 MMP7 MMP9
19
Lung fibrosis 1
11.62 ELN MMP2 MMP9 TIMP1
20
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.6 MMP1 MMP2 MMP3 MMP9 VEGFA
21
Hepatitis C and Hepatocellular Carcinoma 1
11.51 HIF1A MMP1 VEGFA
22
Platelet Aggregation Inhibitor Pathway, Pharmacodynamics 61
11.51 COL3A1 F2 VWF
23
Angiogenesis (CST) 4
11.51 HIF1A MMP2 MMP3 MMP7 MMP9 TIMP1
24
Cell adhesion_Cell-matrix glycoconjugates 22
11.36 ELN MMP1 MMP3 MMP9 TIMP2
25
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.31 MMP1 MMP2 MMP9
26
Development_Leptin signaling via JAK/STAT and MAPK cascades 22
Show member pathways
 11.24 HIF1A TIMP1 VEGFA
27
IL1 and megakaryocytes in obesity 1
11.18 F2 MMP9 TIMP1 TIMP2
28
Angiogenesis (WikiPathways) 1
11.14 HIF1A MMP9 TIMP2 VEGFA
29
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 66
11.08 F2 MMP1 MMP2
30
Immune response_Oncostatin M signaling via JAK-Stat in human cells 22
11.02 MMP1 TIMP1 VEGFA
31
Cell adhesion_ECM remodeling 22
11.01 COL3A1 MMP1 MMP2 MMP3 MMP7 MMP9
32
Syndecan-1-mediated signaling events 1
10.96 MMP1 MMP7 MMP9
33
miR-148a/miR-31/FIH1/HIF1andalpha;-Notch signaling in glioblastoma 1
10.59 HIF1A VEGFA
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GO Terms for Varicose Veins

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Cellular components related to Varicose Veins according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.9 COL3A1 F2 F5 MMP2 MMP3 MMP7
2 extracellular region GO:0005576 9.86 AGGF1 COL3A1 ELN F2 F5 MMP1
3 endoplasmic reticulum lumen GO:0005788 9.72 COL3A1 F2 F5 SERPINC1 TIMP1
4 platelet alpha granule lumen GO:0031093 9.56 F5 TIMP1 VEGFA VWF
5 platelet alpha granule GO:0031091 9.37 F5 VWF
6 extracellular matrix GO:0031012 9.32 COL3A1 ELN MMP1 MMP2 MMP3 MMP7

Biological processes related to Varicose Veins according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.9 AGGF1 HIF1A MMP2 VEGFA
2 extracellular matrix organization GO:0030198 9.88 COL3A1 ELN MMP9 VWF
3 blood coagulation GO:0007596 9.86 F2 F5 SERPINC1 VWF
4 aging GO:0007568 9.81 COL3A1 MMP7 TIMP1 TIMP2
5 response to hypoxia GO:0001666 9.8 HIF1A MMP2 MTHFR VEGFA
6 positive regulation of endothelial cell proliferation GO:0001938 9.77 AGGF1 HIF1A VEGFA
7 cellular protein metabolic process GO:0044267 9.73 F2 F5 MMP1 MMP2 SERPINC1 TIMP1
8 response to cytokine GO:0034097 9.72 COL3A1 TIMP1 TIMP2
9 response to hormone GO:0009725 9.71 FOXC2 TIMP1 TIMP2
10 blood vessel development GO:0001568 9.7 COL3A1 FOXC2 HIF1A
11 cytokine-mediated signaling pathway GO:0019221 9.7 HIF1A MMP1 MMP2 MMP3 MMP9 TIMP1
12 platelet degranulation GO:0002576 9.67 F5 TIMP1 VEGFA VWF
13 lactation GO:0007595 9.63 HIF1A SERPINC1 VEGFA
14 hemostasis GO:0007599 9.62 F2 F5 SERPINC1 VWF
15 regulation of blood coagulation GO:0030193 9.61 F2 SERPINC1
16 blood circulation GO:0008015 9.61 ELN F5 MTHFR
17 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.58 TIMP1 TIMP2
18 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.48 HIF1A VEGFA
19 collagen catabolic process GO:0030574 9.43 COL3A1 MMP1 MMP2 MMP3 MMP7 MMP9
20 negative regulation of metallopeptidase activity GO:1905049 9.4 TIMP1 TIMP2
21 extracellular matrix disassembly GO:0022617 9.23 ELN MMP1 MMP2 MMP3 MMP7 MMP9
22 proteolysis GO:0006508 10.04 F2 MMP1 MMP2 MMP3 MMP7 MMP9

Molecular functions related to Varicose Veins according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.87 MMP1 MMP2 MMP3 MMP7 MMP9 TIMP1
2 peptidase activity GO:0008233 9.85 F2 MMP1 MMP2 MMP3 MMP7 MMP9
3 heparin binding GO:0008201 9.71 F2 MMP7 SERPINC1 VEGFA
4 metallopeptidase activity GO:0008237 9.65 MMP1 MMP2 MMP3 MMP7 MMP9
5 serine-type endopeptidase activity GO:0004252 9.63 F2 MMP1 MMP2 MMP3 MMP7 MMP9
6 endopeptidase activity GO:0004175 9.61 MMP1 MMP3 MMP9
7 metalloendopeptidase activity GO:0004222 9.35 MMP1 MMP2 MMP3 MMP7 MMP9
8 protease binding GO:0002020 9.02 COL3A1 SERPINC1 TIMP1 TIMP2 VWF
9 protein binding GO:0005515 10.39 AGGF1 COL3A1 ELN F2 F5 FOXC2
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Sources for Varicose Veins

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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