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VARIX
MCID: VRC005
MIFTS: 65

Varicose Veins (VARIX)

Categories: Blood diseases, Cardiovascular diseases, Skin diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Varicose Veins

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MalaCards integrated aliases for Varicose Veins:

Name: Varicose Veins 57 12 29 6 43 44 15 63 63
Varices 12 15
Venous Ectasia 12
Venous Varices 12
Varicosity 73
Varix 12

Characteristics:

OMIM:

57
Inheritance:
multifactorial vs. autosomal or x-linked dominant


Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Skin diseases Blood diseases
See all MalaCards categories (disease lists)


External Ids:

OMIM 57 192200
Disease Ontology 12 DOID:799
ICD10 33 I83.90
MeSH 44 D014648
NCIt 50 C35114
SNOMED-CT 68 12856003
MedGen 42 C0042345
SNOMED-CT via HPO 69 128060009 399989005
UMLS 73 C0042345
Sources

Summaries for Varicose Veins

About this section
MedlinePlus : 43 Varicose veins are swollen, twisted veins that you can see just under the skin. They usually occur in the legs, but also can form in other parts of the body. Hemorrhoids are a type of varicose vein. Your veins have one-way valves that help keep blood flowing toward your heart. If the valves are weak or damaged, blood can back up and pool in your veins. This causes the veins to swell, which can lead to varicose veins. Varicose veins are very common. You are more at risk if you are older, are female, have obesity, don't exercise, or have a family history of varicose veins. They can also be more common in pregnancy. Doctors often diagnose varicose veins from a physical exam. Sometimes you may need additional tests. Exercising, losing weight, elevating your legs when resting, and not crossing them when sitting can help keep varicose veins from getting worse. Wearing loose clothing and avoiding long periods of standing can also help. If varicose veins are painful or you don't like the way they look, your doctor may recommend procedures to remove them. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Varicose Veins, also known as varices, is related to budd-chiari syndrome and chronic venous insufficiency, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Varicose Veins is ELN (Elastin), and among its related pathways/superpathways are Integrin Pathway and Cytokine Signaling in Immune system. The drugs Propranolol and Carvedilol have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and heart, and related phenotypes are varicose veins and Reduced mammosphere formation

Disease Ontology : 12 A vein disease that is characterized by swollen, twisted veins visible just under the surface of the skin.

PubMed Health : 63 About varicose veins: Varicose (VAR-i-kos) veins are swollen, twisted veins that you can see just under the surface of the skin. These veins usually occur in the legs, but they also can form in other parts of the body.Varicose veins are a common condition. They usually cause few signs and symptoms. Sometimes varicose veins cause mild to moderate pain, blood clots, skin ulcers (sores), or other problems.

Wikipedia : 76 Varicose veins are veins that have become enlarged and twisted. The term commonly refers to the veins on... more...

Description from OMIM: 192200
Sources

Related Diseases for Varicose Veins

About this section

Diseases related to Varicose Veins via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 473)
# Related Disease Score Top Affiliating Genes
1 budd-chiari syndrome 31.7 SERPINC1 MTHFR F5 F2
2 chronic venous insufficiency 31.2 MMP1 MMP9 TIMP1
3 portal hypertension 31.2 F2 VEGFA VWF
4 venous insufficiency 31.0 VWF TIMP1 MMP9 MMP1 F2
5 active peptic ulcer disease 30.6 F2 VWF
6 thrombophlebitis 30.6 SERPINC1 MTHFR F5 F2
7 portal vein thrombosis 30.5 SERPINC1 MTHFR F5 F2
8 vein disease 30.5 VEGFA SERPINC1 MTHFR F5 F2
9 thrombosis 30.5 VWF SERPINC1 MTHFR F5 F2
10 post-thrombotic syndrome 30.3 F2 F5 SERPINC1
11 sudden sensorineural hearing loss 30.1 MTHFR F5 F2
12 hepatoportal sclerosis 30.0 ELN F2
13 thrombophilia due to thrombin defect 30.0 F2 VWF SERPINC1 MTHFR F5
14 arteriovenous malformation 30.0 MMP3 MMP9 VEGFA
15 thrombophilia 30.0 VWF SERPINC1 MTHFR F5 F2
16 von willebrand's disease 30.0 F2 F5 VWF
17 gastroschisis 29.9 F2 F5 MTHFR
18 esophageal cancer 29.8 HIF1A MMP2 MMP7 MMP9 TIMP1 VEGFA
19 aortic disease 29.8 ELN MMP2 MMP9
20 pulmonary embolism 29.7 VWF SERPINC1 MTHFR F5 F2
21 spinal stenosis 29.7 MMP3 TIMP1 TIMP2
22 cryptogenic cirrhosis 29.7 F2 F5 MTHFR
23 arteries, anomalies of 29.7 VWF VEGFA SERPINC1 MMP9
24 intravascular papillary endothelial hyperplasia 29.6 HIF1A VEGFA
25 factor viii deficiency 29.6 F2 F5 VWF
26 mesenteric vascular occlusion 29.6 F2 MTHFR
27 disseminated intravascular coagulation 29.4 F2 F5 SERPINC1
28 cerebrovascular disease 29.4 VWF MTHFR MMP9 F5 F2
29 spinal cord infarction 29.3 SERPINC1 MTHFR F5 F2
30 protein s deficiency 29.3 SERPINC1 MTHFR F5 F2
31 protein c deficiency 29.3 SERPINC1 MTHFR F5 F2
32 patent foramen ovale 29.3 SERPINC1 MTHFR F5 F2
33 rheumatoid arthritis 29.2 MMP1 MMP3 MMP9 TIMP1 VEGFA
34 heart disease 29.2 VWF VEGFA SERPINC1 MTHFR MMP3 F2
35 vascular disease 29.2 VWF VEGFA SERPINC1 MTHFR MMP9 MMP3
36 antiphospholipid syndrome 29.1 VWF SERPINC1 MTHFR F5 F2
37 stroke, ischemic 29.1 F2 F5 MTHFR SERPINC1 VWF
38 colorectal cancer 29.0 HIF1A MMP1 MMP2 MMP7 MMP9 MTHFR
39 myocardial infarction 28.6 VWF VEGFA TIMP1 SERPINC1 MTHFR MMP9
40 esophageal varix 12.4
41 colonic varices without portal hypertension 12.1
42 varicocele 11.9
43 klippel-trenaunay-weber syndrome 11.7
44 lymphedema-distichiasis syndrome 11.4
45 nodular regenerative hyperplasia 11.4
46 hydrops fetalis, nonimmune, and/or atrial septal defect 11.3
47 cutis marmorata telangiectatica congenita 11.2
48 torticollis, keloids, cryptorchidism, and renal dysplasia 11.2
49 hepatic fibrosis, severe due to schistosoma mansoni infection 11.2
50 liposarcoma 11.2

Graphical network of the top 20 diseases related to Varicose Veins:



Diseases related to Varicose Veins
Sources

Symptoms & Phenotypes for Varicose Veins

About this section

Symptoms via clinical synopsis from OMIM:

57
Vascular:
varicose veins

Misc:
twice as frequent in females as in males


Clinical features from OMIM:

192200

Human phenotypes related to Varicose Veins:

32
# Description HPO Frequency HPO Source Accession
1 varicose veins 32 HP:0002619

UMLS symptoms related to Varicose Veins:


angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Varicose Veins according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 COL3A1 FOXC2 MMP2 MMP7 SERPINC1 TIMP1

MGI Mouse Phenotypes related to Varicose Veins:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.36 AGGF1 COL3A1 F2 F5 FOXC2 HIF1A
2 homeostasis/metabolism MP:0005376 10.36 COL3A1 F2 F5 FOXC2 HIF1A MMP1
3 immune system MP:0005387 10.28 COL3A1 F2 FOXC2 HIF1A MMP1 MMP2
4 hematopoietic system MP:0005397 10.22 F2 HIF1A MMP2 MMP3 MMP7 MMP9
5 mortality/aging MP:0010768 10.21 AGGF1 COL3A1 F2 F5 FOXC2 HIF1A
6 digestive/alimentary MP:0005381 10.1 COL3A1 F2 FOXC2 HIF1A MMP7 MMP9
7 nervous system MP:0003631 10.07 AGGF1 F2 F5 FOXC2 HIF1A MMP2
8 liver/biliary system MP:0005370 9.95 COL3A1 F5 FOXC2 HIF1A MTHFR SERPINC1
9 neoplasm MP:0002006 9.92 AGGF1 HIF1A MMP1 MMP2 MMP7 MMP9
10 respiratory system MP:0005388 9.81 AGGF1 COL3A1 F2 FOXC2 HIF1A MMP2
11 skeleton MP:0005390 9.61 F2 FOXC2 HIF1A MMP2 MMP3 MMP9
12 vision/eye MP:0005391 9.23 FOXC2 HIF1A MMP2 MMP7 MMP9 MTHFR
Sources

Drugs & Therapeutics for Varicose Veins

About this section

PubMedHealth treatment related to Varicose Veins: 63

Varicose veins are treated with lifestyle changes and medical procedures. The goals of treatment are to relieve symptoms, prevent complications, and improve appearance.If varicose veins cause few symptoms, your doctor may simply suggest making lifestyle changes. If your symptoms are more severe, your doctor may recommend one or more medical procedures. For example, you may need a medical procedure if you have a lot of pain, blood clots, or skin disorders caused by your varicose veins.Some people who have varicose veins choose to have procedures to improve how their veins look.Although treatment can help existing varicose veins, it can't keep new varicose veins from forming.

Drugs for Varicose Veins (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 302)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propranolol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 525-66-6 4946
2
Carvedilol Approved, Investigational Phase 4,Phase 3,Not Applicable 72956-09-3 2585
3
Nadolol Approved Phase 4,Phase 3 42200-33-9 39147
4
Epinephrine Approved, Vet_approved Phase 4,Not Applicable 51-43-4 5816
5
Racepinephrine Approved Phase 4,Not Applicable 329-65-7 838
6
AT-101 Approved, Investigational Phase 4 90141-22-3, 652-67-5 12597
7
Prazosin Approved Phase 4 19216-56-9 4893
8
Nitric Oxide Approved Phase 4,Phase 3,Phase 2 10102-43-9 145068
9
Isosorbide Dinitrate Approved, Investigational Phase 4 87-33-2 6883
10
Simvastatin Approved Phase 4,Phase 3,Not Applicable 79902-63-9 54454
11
Losartan Approved Phase 4 114798-26-4 3961
12
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
13
Polidocanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9002-92-0
14
Ethiodized oil Approved, Investigational Phase 4,Phase 3,Not Applicable 8008-53-5
15
Lypressin Approved Phase 4,Not Applicable 50-57-7
16
Terlipressin Approved, Investigational Phase 4,Phase 3,Not Applicable 14636-12-5 72081
17
Octreotide Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 83150-76-9 383414 6400441
18
Somatostatin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 51110-01-1, 38916-34-6 53481605
19
Entecavir Approved, Investigational Phase 4,Phase 1,Phase 2 142217-69-4 153941
20
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
21
Alginic acid Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 9005-32-7
22
Thrombin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable
23
Ethanolamine oleate Approved Phase 4,Phase 3 2272-11-9
24
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
25
Ceftriaxone Approved Phase 4,Not Applicable 73384-59-5 5479530 5361919
26
Colchicine Approved Phase 4 64-86-8 6167 2833
27
Peginterferon alfa-2b Approved Phase 4,Phase 3 99210-65-8, 215647-85-1
28
Pantoprazole Approved Phase 4 102625-70-7 4679
29
Petrolatum Approved, Investigational Phase 4,Phase 2,Not Applicable 8009-03-8
30
Sodium Tetradecyl Sulfate Approved, Investigational Phase 4,Not Applicable 1191-50-0, 139-88-8 5248 14492
31
Esomeprazole Approved, Investigational Phase 4,Not Applicable 161796-78-7, 119141-88-7 4594 9579578
32
Ibuprofen Approved Phase 4,Not Applicable 15687-27-1 3672
33
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
34
Acetaminophen Approved Phase 4,Phase 1 103-90-2 1983
35
Tranexamic Acid Approved Phase 4 1197-18-8 5526
36
Coal tar Approved Phase 4,Not Applicable 8007-45-2
37
Telbivudine Approved, Investigational Phase 4 3424-98-4 159269
38
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
39
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
40
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
41
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
42
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 11103-57-4, 68-26-8 445354
43
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
44 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2,Not Applicable
45 Adrenergic Agents Phase 4,Phase 3,Phase 2,Not Applicable
46 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Not Applicable
47 Adrenergic beta-Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
48 Adrenergic Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
49 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Vasodilator Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 599)
# Name Status NCT ID Phase Drugs
1 Preventing Recurrent Bleeding After Eradication of Esophageal Varices Unknown status NCT02740166 Phase 4 propranolol
2 Early Feeding Following Ligation of Acute Bleeding Varices Unknown status NCT01287702 Phase 4
3 Primary Prevention of Patients With Hepatocellular Carcinoma and Concomitant Esophageal Varices Unknown status NCT01970748 Phase 4 Propranolol
4 The Effect of Carvedilol Vs Propranolol in Cirrhotic Patients With Variceal Bleeding Unknown status NCT02385422 Phase 4 Carvedilol;Propranolol
5 The Effect of Carvedilol VS Endoscopic Therapy in Primary Prophylaxis of High-risk Esophageal Gastric Variceal Bleeding Unknown status NCT02695732 Phase 4 Carvedilol
6 The Effect of Hepatic Vein Pressure Gradient(HVPG)-Guided Therapy in Cirrhotic Patients With Esophagogastric Varices Unknown status NCT02638415 Phase 4 Carvedilol
7 Endoscopic Treatment Alone Versus Combined Propranolol and Endoscopic Treatment of Acute Variceal Hemorrhage in Patients With Hepatocellular Carcinoma Unknown status NCT01451658 Phase 4 propranolol
8 Primary Prevention of Gastric Variceal Bleeding : Endoscopic Treatment Versus Non-selective Beta-blocker Unknown status NCT01298271 Phase 4 propranolol
9 Banding Ligation With Carvedilol Versus Carvedilol for the Prevention of First Bleeding Unknown status NCT01383044 Phase 4 carvedilol
10 Compression Aided Management of Edema in Patients With C3 Venous Disease Unknown status NCT00766974 Phase 4
11 Fluid Infusion During Breast Surgery Unknown status NCT00431743 Phase 4 Hydroxyethylstarch 130/0,4;Lactated Ringer's solution
12 RCT of Carvedilol Versus Variceal Band Ligation in the Primary Prophylaxis of Oesophageal Variceal Haemorrhage Unknown status NCT01070641 Phase 4 Carvedilol
13 Trial of Hemospray Plus Epinephrine Injection Versus Endoscopic Hemoclip Unknown status NCT02537353 Phase 4 Hemospray;Adrenaline
14 Treatment for Prevention of Variceal Rebleeding Guided by the Hemodynamic Response Unknown status NCT00563602 Phase 4
15 Hemodynamic Effect of Simvastatin With Beta Blockers in Clinical Portal Hypertension Unknown status NCT01282385 Phase 4 Simvastatin;placebo
16 Prevention of Decompensation in Liver Cirrhosis Unknown status NCT00239096 Phase 4 losartan (drug)
17 A Study Of Pain And Quality Of Life Outcomes In Subjects With a Single Painful Venous Leg Ulcer Treated With Apligraf® Unknown status NCT02011724 Phase 4
18 Clinical Evaluation of the SNaP Wound Care System Unknown status NCT01113658 Phase 4
19 PROPRANOLOL PLUS LIGATION REDUCES RECURRENCE OF ESOPHAGEAL VARICES? Completed NCT01893541 Phase 4 PROPRANOLOL
20 Efficacy and Safety of Esarin Gel in Chronic Venous Insufficiency and Varicose Veins Completed NCT02346058 Phase 4 Esarin Gel
21 COMFORT: A Multicenter, Open-label, Randomized, Crossover Study Completed NCT02462720 Phase 4 Varithena®
22 Carvedilol as an Adjunct to Endoscopic Cyanoacrylate Injection for Secondary Prophylaxis of Gastric Variceal Bleeding Completed NCT02504723 Phase 4 carvedilol;cyanoacrylate
23 Time Interval for Endoscopic Variceal Ligation Completed NCT01291277 Phase 4
24 Surgery Versus Sclerotherapy for Isolated Accessory Great Saphenous Vein Varicosis Completed NCT02010723 Phase 4 sclerotherapy with aethoxysclerol foam
25 Study Protocol Comparing Polidocanol Versus Hypertonic Glucose for Treatment of Reticular Veins Completed NCT02054325 Phase 4 Polidocanol with Glucose;Glucose
26 A Randomized Controlled Trial Comparing Band Ligation and Cyanoacrylate Injection for Esophageal Varices Completed NCT00799851 Phase 4 cyanoacrylate injection
27 Hemodynamic Effects of Terlipressin and High Dose Octreotide Completed NCT02119884 Phase 4 Terlipressin;Octreotide
28 A Trial of Ligation Plus Nadolol Versus Nadolol Alone in the Prophylaxis of First Variceal Bleeding in Cirrhosis Completed NCT00921349 Phase 4 Nadolol
29 Polidocanol Versus Glucose Treatment of Telangiectasia Trial Completed NCT02657252 Phase 4 Glucose;Polidocanol with Glucose
30 Painless Local Infiltration Anesthesia Completed NCT01611324 Phase 4 Mepivacaine chlorhydrate 2% in Sodium Bicarbonate 1.4%;Mepivacaine chlorhydrate 2% with epinephrine in NS 0.9%
31 EVL (Endoscopic Variceal Ligation) Plus Vasoconstrictor vs.Ligation Plus PPI( Proton Pump Inhibitor) in the Control of Acute Esophageal Variceal Bleeding Completed NCT01112852 Phase 4 pantoloc 40 mg;somatostatin or terlipressin
32 Comparison of 3 Days and 7 Days Intravenous Ceftriaxone Prophylaxis for Variceal Bleeding Completed NCT00838864 Phase 4 ceftrioxone;ceftrioxone
33 Study on B-blockers to Prevent Decompensation of Cirrhosis With HTPortal Completed NCT01059396 Phase 4 propranolol;carvedilol;placebo
34 Comparison of Endoscopic Injection of Conventional and Double Doses Cyanoacrylate for Gastric Variceal Hemorrhage Completed NCT00735358 Phase 4
35 ClosureFAST vs. Laser Ablation for the Treatment of GSV Disease: A Multicenter, Single-Blinded, Randomized Study. Completed NCT00509392 Phase 4
36 The Safety & Efficacy of Terlipressin vs Octreotide for the Control of Variceal Bleed Completed NCT00534677 Phase 4 Terlipressin;Octreotide
37 A Trial of Nadolol Plus Isosorbide Mononitrate Versus Carvedilol for the Prevention of Variceal Rebleeding Completed NCT01103154 Phase 4 carvedilol;nadolol + ISMN
38 Comparison of Terlipressin, Somatostatin, and Octreotide for Control of Variceal Bleeding Completed NCT00966355 Phase 4 Terlipressin;Somatostatin;Octreotide
39 Short Course Terlipressin for Control of Acute Variceal Bleeding Completed NCT00369694 Phase 4 Terlipressin;Terlipressin & then Dummy
40 Radiofrequency Ablation vs. Laser Ablation of the Incompetent Small Saphenous Vein Completed NCT02248740 Phase 4
41 Radiofrequency Ablation vs Laser Ablation of the Incompetent Greater Saphenous Vein Completed NCT02236338 Phase 4
42 Peripheral Vascular Disease and Nerve Stimulation Completed NCT01942941 Phase 4
43 Secondary Prophylaxis After Variceal Bleeding in Non-Responders Completed NCT00450164 Phase 4 Nadolol;Isosorbide mononitrate;Prazosin
44 Optimized Treatment and Regression of HBV-induced Compensated Liver Cirrhosis Completed NCT01943617 Phase 4 Entecavir;Thymosin-α
45 Band Ligation Versus Transjugular Intrahepatic Portosystemic Stent Shunt (TIPS) in Cirrhotics With Recurrent Variceal Bleeding Non Responding to Medical Therapy Completed NCT00570973 Phase 4
46 Study of Long-term Peg Intron vs. Colchicine in Non-responders. Completed NCT00179413 Phase 4 PEG -Intron;Colchicine
47 Vasoactive Drugs in Real World Practice Completed NCT02757703 Phase 4 Somatostatin;Terlipressin;Pantoprazole
48 A Pilot Trial of the Use of ReCell® Autologous Cell Harvesting Device for Venous Leg Ulcers Completed NCT01743053 Phase 4
49 Trial on the Efficacy of Prontosan Wound Irrigation Solution and Prontosan Wound Gel Completed NCT01153633 Phase 4
50 Wound Fluid Protease Levels During Use of Novel Wound Dressing Completed NCT01567150 Phase 4

Search NIH Clinical Center for Varicose Veins

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: varicose veins

Sources

Genetic Tests for Varicose Veins

About this section

Genetic tests related to Varicose Veins:

# Genetic test Affiliating Genes
1 Varicose Veins 29
Sources

Anatomical Context for Varicose Veins

About this section

MalaCards organs/tissues related to Varicose Veins:

41
Liver, Skin, Heart, Spleen, Testes, Lung, Colon
Sources

Publications for Varicose Veins

About this section

Articles related to Varicose Veins:

(show top 50) (show all 1967)
# Title Authors Year
1
The influence of age on valve disease in patients with varicose veins analysed by transmission electron microscopy and stereology. ( 29808768 )
2018
2
Five-year follow-up of a randomized clinical trial comparing open surgery, foam sclerotherapy and endovenous laser ablation for great saphenous varicose veins. ( 29652086 )
2018
3
A national survey on management of varicose veins in China. ( 29439933 )
2018
4
Presence of Varicose Veins is the Most Important Risk Factor for Developing PTS. ( 29966166 )
2018
5
Treating great and small saphenous vein insufficiency with histoacryl in patients with symptomatic varicose veins and increased risk of surgery. ( 29890917 )
2018
6
Endovenous Treatment of Varicose Veins in Patients With Pyoderma Gangrenosum. ( 29933301 )
2018
7
Ecchymosis: A novel sign in patients with varicose veins. ( 29660929 )
2018
8
Prospective comparison of effect of ligation and foam sclerotherapy with foam sclerotherapy alone for varicose veins. ( 29428536 )
2018
9
Polymorphisms in inflammation-related genes and the risk of primary varicose veins in ethnic Russians. ( 29247331 )
2018
10
Surgical treatment of recurrent varicose veins in the lower limbs associated with endovascular treatment of iliac vein stenosis. ( 29337179 )
2018
11
Systematic review and meta-analysis of endovascular and surgical revascularization for patients with chronic lower extremity venous insufficiency and varicose veins. ( 29421005 )
2018
12
A Comparison of Concomitant Tributary Laser Ablation and Foam Sclerotherapy in Patients Undergoing Truncal Endovenous Laser Ablation for Lower Limb Varicose Veins. ( 29705225 )
2018
13
Acute Effects of Graduated Elastic Compression Stockings in Patients with Symptomatic Varicose Veins: A Randomised Double Blind Placebo Controlled Trial. ( 29129457 )
2018
14
Polymorphisms of genes involved in inflammation and blood vessel development influence the risk of varicose veins. ( 29660117 )
2018
15
A leg ulcer with pulsating varicose veins - from the legs to the heart. ( 29115044 )
2018
16
ClariVeina8c - One year results of mechano-chemical ablation for varicose veins in a multi-ethnic Asian population from Singapore. ( 29690839 )
2018
17
Endovenous Thermal Ablation of Recurrent Varicose Veins due to Residual Great Saphenous Venous Insufficiency After Saphenous Venous Surgery: A Comparative Study. ( 29781902 )
2018
18
Compression with 23a88mmHg or 35a88mmHg stockings after saphenous catheter foam sclerotherapy and phlebectomy of varicose veins: A randomized controlled study. ( 29754530 )
2018
19
A 1470-nm laser combined with foam sclerotherapy in day surgery: a better choice for lower limb varicose veins. ( 29687409 )
2018
20
Varicose Veins and Lower Extremity Venous Insufficiency. ( 29628617 )
2018
21
Haemorrhage from varicose veins and varicose ulceration: A systematic review. ( 29808553 )
2018
22
Re: "Catheter Foam Sclerotherapy of the Great Saphenous Vein, with Peri-saphenous Tumescence Infiltration and Saphenous Irrigation"-Is Modified Catheter Foam Sclerotherapy a Step Back in the Evolution of Endovenous Ablation for Varicose Veins? ( 29246435 )
2018
23
Compression therapy for uncomplicated varicose veins - Too little for too much? ( 29954256 )
2018
24
Prospective, double-blind, randomized controlled trial comparing electrocoagulation and radiofrequency in theA treatment of patients with great saphenous vein insufficiency and lower limb varicose veins. ( 29229466 )
2018
25
Endovenous Management of Varicose Veins. ( 29874921 )
2018
26
Symptomatic recurrent varicose veins due to primary avalvular varicose anomalies (PAVA): A previously unreported cause of recurrence. ( 29796272 )
2018
27
Commentary on pelvic venous reflux in males with varicose veins and recurrent varicose veins. ( 29431010 )
2018
28
The haemodynamic causes of skin changes in limbs with primary varicose veins. ( 29726741 )
2018
29
The role of compression after endovenous ablation of varicose veins. ( 29680439 )
2018
30
Esophageal Varices in Adolescent and Young Adult Males with Acute Lymphocytic Leukemia. ( 30335538 )
2018
31
Gastric varices and splenic vein obstruction during steroid treatment for autoimmune pancreatitis: A case report and literature review. ( 30142813 )
2018
32
Direct reopening of the occluded hepatic veins of Budd-Chiari syndrome: verification of our operative method by the perioperative course of esophageal varices. ( 28828590 )
2018
33
Non-invasive Prediction of High-risk Varices in Patients with Primary Biliary Cholangitis and Primary Sclerosing Cholangitis. ( 30315285 )
2018
34
Esophageal Ulcers in Primary Biliary Cholangitis: A Rare Cause of Hematemesis in the Setting of Portal Hypertension and Esophageal Varices. ( 30344813 )
2018
35
Chronic venous insufficiency and varicose veins of the lower extremities. ( 30360023 )
2018
36
Insulin/high-density lipoprotein cholesterol ratio: A newly-discovered predictor of esophageal varices in patients with hepatitis C virus-related cirrhosis in the absence of diabetes mellitus. ( 30541737 )
2018
37
A Young Adult Patient with Nonalcoholic Steatohepatitis Developed Severe Gastroesophageal Varices Associated with Severe Obesity and Diabetes Mellitus. ( 30283282 )
2018
38
Comparison of patients with hepatic encephalopathy and those with gastric varices before and after balloon-occluded retrograde transvenous obliteration. ( 29882396 )
2018
39
Risk factors for exacerbation of gastroesophageal varices and portosystemic encephalopathy during treatment with nucleos(t)ide analogs for hepatitis B virus-related cirrhosis. ( 29114970 )
2018
40
Isolated Gastric Varices in a Patient with Essential Thrombocythemia. ( 30359570 )
2018
41
Reply to: "Non-invasive prediction of oesophageal varices in patients with cirrhosis secondary to non-alcoholic fatty liver disease". ( 30193923 )
2018
42
Non-invasive prediction of oesophageal varices in patients with cirrhosis secondary to non-alcoholic fatty liver disease. ( 30206018 )
2018
43
Non-invasive prediction of esophageal varices by stiffness and platelet in non-alcoholic fatty liver disease cirrhosis. ( 29802949 )
2018
44
Relationship between various hepatic function scores and the formation of esophageal varices in patients with HIV/hepatitis C virus co-infection due to contaminated blood products for hemophilia. ( 30358037 )
2018
45
Sclerotherapy of esophageal varices in hemophilia patients with liver cirrhosis - a prospective, controlled clinical study. ( 29513248 )
2018
46
The presence of varices in patients after hepatitis C eradication predicts deterioration in the FIB-4 index. ( 30549372 )
2018
47
Transient Elastography Identifies the Risk of Esophageal Varices and Bleeding in Patients With Hepatitis B Virus-Related Liver Cirrhosis. ( 30020268 )
2018
48
Predicting Esophageal Varices in Cirrhotic Hepatitis C Virus Patients Using Noninvasive Measurement of Insulin Resistance Variables. ( 30073932 )
2018
49
Propofol is a more effective and safer sedative agent than midazolam in endoscopic injection sclerotherapy for esophageal varices in patients with liver cirrhosis: a randomized controlled trial. ( 30344206 )
2018
50
Endoscopic treatment or balloon-occluded retrograde transvenous obliteration is safe for patients with esophageal/gastric varices in Child-Pugh class C end-stage liver cirrhosis. ( 30408943 )
2018
Sources

Variations for Varicose Veins

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ClinVar genetic disease variations for Varicose Veins:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ELN NM_001278939.1(ELN): c.898A> T (p.Thr300Ser) single nucleotide variant Uncertain significance rs766735416 GRCh37 Chromosome 7, 73466262: 73466262
2 ELN NM_001278939.1(ELN): c.898A> T (p.Thr300Ser) single nucleotide variant Uncertain significance rs766735416 GRCh38 Chromosome 7, 74051932: 74051932
Sources

Expression for Varicose Veins

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Search GEO for disease gene expression data for Varicose Veins.
Sources

Pathways for Varicose Veins

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Pathways related to Varicose Veins according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Integrin Pathway 64
Show member pathways
 13.37 COL3A1 ELN F2 MMP1 MMP2 MMP3
2
Cytokine Signaling in Immune system 66
Show member pathways
 13.33 HIF1A MMP1 MMP2 MMP3 MMP9 TIMP1
3
Response to elevated platelet cytosolic Ca2+ 66
Show member pathways
 13.27 F2 F5 MMP1 SERPINC1 TIMP1 VEGFA
4
Pathways in cancer 37
12.77 HIF1A MMP1 MMP2 MMP9 VEGFA
5
Collagen chain trimerization 66
Show member pathways
 12.76 COL3A1 ELN F2 F5 MMP3 MMP7
6
Degradation of the extracellular matrix 66
Show member pathways
 12.63 COL3A1 ELN MMP1 MMP2 MMP3 MMP7
7
Proteoglycans in cancer 37
12.25 HIF1A MMP2 MMP9 VEGFA
8
G-protein signaling Ras family GTPases in kinase cascades (scheme) 22
Show member pathways
 12.25 HIF1A MMP1 MMP3 TIMP1 VEGFA
9
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 22
Show member pathways
 12.2 COL3A1 ELN F2 MMP1 MMP2 MMP3
10
Colorectal Cancer Metastasis 64
12.14 MMP1 MMP2 MMP7 MMP9 VEGFA
11
Formation of Fibrin Clot (Clotting Cascade) 66
Show member pathways
 12.13 F2 F5 SERPINC1 VWF
12
Complement and coagulation cascades 1 37
12.07 F2 F5 SERPINC1 VWF
13
Microglia Activation During Neuroinflammation: Overview 65
Show member pathways
 12.01 F2 MMP2 MMP3 MMP7 MMP9
14
Interleukin-4 and 13 signaling 66
11.86 HIF1A MMP1 MMP2 MMP3 MMP9 TIMP1
15
HIF-1 signaling pathway 37
11.84 HIF1A TIMP1 VEGFA
16
AGE-RAGE signaling pathway in diabetic complications 37
11.83 COL3A1 MMP2 VEGFA
17
Rheumatoid arthritis 37
11.79 MMP1 MMP3 VEGFA
18
Bladder cancer 37 1
11.72 MMP1 MMP2 MMP9 VEGFA
19
Matrix Metalloproteinases 1
Show member pathways
 11.7 MMP1 MMP2 MMP3 MMP7 MMP9 TIMP1
20
AGE/RAGE pathway 1
11.67 HIF1A MMP2 MMP7 MMP9
21
Lung fibrosis 1
11.64 ELN MMP2 MMP9 TIMP1
22
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.6 MMP1 MMP2 MMP3 MMP9 VEGFA
23
Hepatitis C and Hepatocellular Carcinoma 1
11.52 HIF1A MMP1 VEGFA
24
Platelet Aggregation Inhibitor Pathway, Pharmacodynamics 61
11.52 COL3A1 F2 VWF
25
Angiogenesis (CST) 4
11.51 HIF1A MMP2 MMP3 MMP7 MMP9 TIMP1
26
Cell adhesion_Cell-matrix glycoconjugates 22
11.36 ELN MMP1 MMP3 MMP9 TIMP2
27
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.32 MMP1 MMP2 MMP9
28
Development_Leptin signaling via JAK/STAT and MAPK cascades 22
Show member pathways
 11.26 HIF1A TIMP1 VEGFA
29
IL1 and megakaryocytes in obesity 1
11.18 F2 MMP9 TIMP1 TIMP2
30
Angiogenesis (WikiPathways) 1
11.14 HIF1A MMP9 TIMP2 VEGFA
31
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 66
11.09 F2 MMP1 MMP2
32
Immune response_Oncostatin M signaling via JAK-Stat in human cells 22
11.04 MMP1 TIMP1 VEGFA
33
Cell adhesion_ECM remodeling 22
11.01 COL3A1 MMP1 MMP2 MMP3 MMP7 MMP9
34
Syndecan-1-mediated signaling events 1
10.97 MMP1 MMP7 MMP9
35
miR-148a/miR-31/FIH1/HIF1andalpha;-Notch signaling in glioblastoma 1
10.6 HIF1A VEGFA
Sources

GO Terms for Varicose Veins

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Cellular components related to Varicose Veins according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 AGGF1 COL3A1 ELN F2 F5 MMP1
2 endoplasmic reticulum lumen GO:0005788 9.77 COL3A1 F2 F5 SERPINC1 TIMP1
3 collagen-containing extracellular matrix GO:0062023 9.7 COL3A1 ELN MMP2 MMP9 SERPINC1 TIMP2
4 platelet alpha granule lumen GO:0031093 9.62 F5 TIMP1 VEGFA VWF
5 platelet alpha granule GO:0031091 9.4 F5 VWF
6 extracellular matrix GO:0031012 9.36 COL3A1 ELN MMP1 MMP2 MMP3 MMP7
7 extracellular space GO:0005615 10 COL3A1 F2 F5 MMP2 MMP3 MMP7

Biological processes related to Varicose Veins according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.91 AGGF1 HIF1A MMP2 VEGFA
2 extracellular matrix organization GO:0030198 9.9 COL3A1 ELN MMP9 VWF
3 blood coagulation GO:0007596 9.86 F2 F5 SERPINC1 VWF
4 positive regulation of endothelial cell proliferation GO:0001938 9.78 AGGF1 HIF1A VEGFA
5 response to hypoxia GO:0001666 9.77 HIF1A MMP2 MMP3 MTHFR VEGFA
6 response to cytokine GO:0034097 9.75 COL3A1 TIMP1 TIMP2
7 response to hormone GO:0009725 9.74 FOXC2 TIMP1 TIMP2
8 cellular protein metabolic process GO:0044267 9.73 F2 F5 MMP1 MMP2 SERPINC1 TIMP1
9 blood vessel development GO:0001568 9.72 COL3A1 FOXC2 HIF1A
10 outflow tract morphogenesis GO:0003151 9.71 ELN HIF1A VEGFA
11 platelet degranulation GO:0002576 9.71 F5 TIMP1 VEGFA VWF
12 cytokine-mediated signaling pathway GO:0019221 9.7 HIF1A MMP1 MMP2 MMP3 MMP9 TIMP1
13 lactation GO:0007595 9.65 HIF1A SERPINC1 VEGFA
14 positive regulation of protein oligomerization GO:0032461 9.62 MMP1 MMP3
15 regulation of blood coagulation GO:0030193 9.62 F2 SERPINC1
16 hemostasis GO:0007599 9.62 F2 F5 SERPINC1 VWF
17 blood circulation GO:0008015 9.61 ELN F5 MTHFR
18 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.59 TIMP1 TIMP2
19 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.52 HIF1A TIMP1
20 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.51 HIF1A VEGFA
21 regulation of neuroinflammatory response GO:0150077 9.49 MMP3 MMP9
22 negative regulation of metallopeptidase activity GO:1905049 9.46 TIMP1 TIMP2
23 collagen catabolic process GO:0030574 9.35 MMP1 MMP2 MMP3 MMP7 MMP9
24 extracellular matrix disassembly GO:0022617 9.17 MMP1 MMP2 MMP3 MMP7 MMP9 TIMP1
25 proteolysis GO:0006508 10.06 F2 MMP1 MMP2 MMP3 MMP7 MMP9

Molecular functions related to Varicose Veins according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.87 MMP1 MMP2 MMP3 MMP7 MMP9 TIMP1
2 peptidase activity GO:0008233 9.85 F2 MMP1 MMP2 MMP3 MMP7 MMP9
3 heparin binding GO:0008201 9.71 F2 MMP7 SERPINC1 VEGFA
4 metallopeptidase activity GO:0008237 9.65 MMP1 MMP2 MMP3 MMP7 MMP9
5 endopeptidase activity GO:0004175 9.63 MMP1 MMP3 MMP9
6 serine-type endopeptidase activity GO:0004252 9.63 F2 MMP1 MMP2 MMP3 MMP7 MMP9
7 metalloendopeptidase inhibitor activity GO:0008191 9.48 TIMP1 TIMP2
8 metalloendopeptidase activity GO:0004222 9.35 MMP1 MMP2 MMP3 MMP7 MMP9
9 protease binding GO:0002020 9.02 COL3A1 SERPINC1 TIMP1 TIMP2 VWF
10 protein binding GO:0005515 10.36 AGGF1 COL3A1 ELN F2 F5 FOXC2
Sources

Sources for Varicose Veins

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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