VARIX
MCID: VRC005
MIFTS: 61

Varicose Veins (VARIX)

Categories: Blood diseases, Cardiovascular diseases, Skin diseases

Aliases & Classifications for Varicose Veins

MalaCards integrated aliases for Varicose Veins:

Name: Varicose Veins 57 12 6 43 44 15 63 63
Varices 12 15
Venous Ectasia 12
Venous Varices 12
Varicosity 72
Varix 12

Characteristics:

OMIM:

57
Inheritance:
multifactorial vs. autosomal or x-linked dominant


HPO:

32

Classifications:



External Ids:

Disease Ontology 12 DOID:799
OMIM 57 192200
MeSH 44 D014648
NCIt 50 C35114
SNOMED-CT 68 12856003
ICD10 33 I83.90
MedGen 42 C0042345
UMLS 72 C0042345

Summaries for Varicose Veins

MedlinePlus : 43 Varicose veins are swollen, twisted veins that you can see just under the skin. They usually occur in the legs, but also can form in other parts of the body. Hemorrhoids are a type of varicose vein. Your veins have one-way valves that help keep blood flowing toward your heart. If the valves are weak or damaged, blood can back up and pool in your veins. This causes the veins to swell, which can lead to varicose veins. Varicose veins are very common. You are more at risk if you are older, are female, have obesity, don't exercise, or have a family history of varicose veins. They can also be more common in pregnancy. Doctors often diagnose varicose veins from a physical exam. Sometimes you may need additional tests. Exercising, losing weight, elevating your legs when resting, and not crossing them when sitting can help keep varicose veins from getting worse. Wearing loose clothing and avoiding long periods of standing can also help. If varicose veins are painful or you don't like the way they look, your doctor may recommend procedures to remove them. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Varicose Veins, also known as varices, is related to chronic venous insufficiency and budd-chiari syndrome, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Varicose Veins is ELN (Elastin), and among its related pathways/superpathways are Integrin Pathway and Cytokine Signaling in Immune system. The drugs Propofol and Midazolam have been mentioned in the context of this disorder. Affiliated tissues include liver, spleen and colon, and related phenotypes are varicose veins and Reduced mammosphere formation

Disease Ontology : 12 A vein disease that is characterized by swollen, twisted veins visible just under the surface of the skin.

PubMed Health : 63 About varicose veins: Varicose (VAR-i-kos) veins are swollen, twisted veins that you can see just under the surface of the skin. These veins usually occur in the legs, but they also can form in other parts of the body. Varicose veins are a common condition. They usually cause few signs and symptoms. Sometimes varicose veins cause mild to moderate pain, blood clots, skin ulcers (sores), or other problems.

Wikipedia : 75 Varicose veins are superficial veins that have become enlarged and twisted. Typically they occur just... more...

More information from OMIM: 192200

Related Diseases for Varicose Veins

Diseases related to Varicose Veins via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 804)
# Related Disease Score Top Affiliating Genes
1 chronic venous insufficiency 32.4 TIMP1 MMP9 MMP1
2 budd-chiari syndrome 32.1 SERPINC1 MTHFR F5 F2
3 venous insufficiency 31.9 VWF TIMP1 MMP9 MMP1 F2
4 lipodermatosclerosis 31.5 VEGFA TIMP2 MMP1
5 thrombophlebitis 31.4 SERPINC1 MTHFR F5 F2
6 active peptic ulcer disease 31.4 VWF F2
7 portal hypertension 31.4 VWF VEGFA F2
8 post-thrombotic syndrome 31.2 SERPINC1 F5 F2
9 cryptogenic cirrhosis 31.0 MTHFR F5 F2
10 hepatoportal sclerosis 31.0 F2 ELN
11 arteriovenous malformation 31.0 VEGFA MMP9 MMP3
12 vascular disease 31.0 VWF VEGFA SERPINC1 MTHFR MMP9 MMP3
13 thrombophilia due to thrombin defect 30.9 VWF SERPINC1 MTHFR F5 F2
14 vein disease 30.9 VEGFA SERPINC1 MTHFR F5 F2
15 inguinal hernia 30.8 TIMP2 TIMP1 MMP9 MMP2 MMP1 ELN
16 pulmonary embolism 30.8 VWF SERPINC1 MTHFR F5 F2
17 thrombosis 30.7 VWF SERPINC1 MTHFR F5 F2
18 pneumothorax 30.7 MMP9 MMP2 ELN
19 factor viii deficiency 30.7 VWF F5 F2
20 sudden sensorineural hearing loss 30.6 MTHFR F5 F2
21 disseminated intravascular coagulation 30.6 SERPINC1 F5 F2
22 limb ischemia 30.6 VWF VEGFA HIF1A
23 carotid stenosis 30.6 MTHFR MMP9 MMP1
24 patent foramen ovale 30.5 SERPINC1 MTHFR F5 F2
25 pulmonary disease, chronic obstructive 30.5 TIMP1 MMP9 MMP1 ELN
26 cerebrovascular disease 30.5 VWF MTHFR MMP9 F5 F2
27 aortic disease 30.5 MMP9 MMP2 ELN
28 leech infestation 30.4 SERPINC1 F2
29 cerebral aneurysms 30.4 MMP2 ELN
30 von willebrand's disease 30.4 VWF F5 F2
31 mesenteric vascular occlusion 30.4 MTHFR F2
32 intravascular papillary endothelial hyperplasia 30.3 VEGFA HIF1A
33 spinal stenosis 30.3 TIMP2 TIMP1 MMP3
34 factor v deficiency 30.3 VWF F5 F2
35 portal vein thrombosis 30.3 SERPINC1 MTHFR F5 F2
36 esophageal cancer 30.2 VEGFA TIMP1 MMP9 MMP7 MMP2 HIF1A
37 thrombophilia 30.2 VWF SERPINC1 MTHFR F5 F2
38 protein s deficiency 30.2 SERPINC1 MTHFR F5 F2
39 gingival overgrowth 30.2 TIMP1 MMP3 MMP2 MMP1
40 peripheral vascular disease 30.1 VWF VEGFA SERPINC1 F2
41 giant hemangioma 30.0 SERPINC1 F2
42 fibrosarcoma 30.0 TIMP2 TIMP1 MMP9 MMP3 MMP2 MMP1
43 gastrointestinal system disease 30.0 VEGFA MMP9 MMP2 F2
44 placental abruption 30.0 SERPINC1 MTHFR F5 F2
45 protein c deficiency 30.0 SERPINC1 MTHFR F5 F2
46 homocysteinemia 30.0 SERPINC1 MTHFR F5 F2
47 intracranial embolism 29.9 SERPINC1 F2
48 stroke, ischemic 29.9 VWF SERPINC1 MTHFR F5 F2
49 arteries, anomalies of 29.8 VWF VEGFA SERPINC1 MMP9
50 placenta disease 29.8 SERPINC1 MTHFR F5

Graphical network of the top 20 diseases related to Varicose Veins:



Diseases related to Varicose Veins

Symptoms & Phenotypes for Varicose Veins

Human phenotypes related to Varicose Veins:

32
# Description HPO Frequency HPO Source Accession
1 varicose veins 32 HP:0002619

Symptoms via clinical synopsis from OMIM:

57
Vascular:
varicose veins

Misc:
twice as frequent in females as in males

Clinical features from OMIM:

192200

UMLS symptoms related to Varicose Veins:


angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Varicose Veins according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 COL3A1 FOXC2 MMP2 MMP7 SERPINC1 TIMP1

MGI Mouse Phenotypes related to Varicose Veins:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.36 AGGF1 COL3A1 F2 F5 FOXC2 HIF1A
2 homeostasis/metabolism MP:0005376 10.36 COL3A1 F2 F5 FOXC2 HIF1A MMP1
3 immune system MP:0005387 10.28 COL3A1 F2 FOXC2 HIF1A MMP1 MMP2
4 hematopoietic system MP:0005397 10.22 F2 HIF1A MMP2 MMP3 MMP7 MMP9
5 mortality/aging MP:0010768 10.21 AGGF1 COL3A1 F2 F5 FOXC2 HIF1A
6 digestive/alimentary MP:0005381 10.1 COL3A1 F2 FOXC2 HIF1A MMP7 MMP9
7 nervous system MP:0003631 10.07 AGGF1 F2 F5 FOXC2 HIF1A MMP2
8 liver/biliary system MP:0005370 9.95 COL3A1 F5 FOXC2 HIF1A MTHFR SERPINC1
9 neoplasm MP:0002006 9.92 AGGF1 HIF1A MMP1 MMP2 MMP7 MMP9
10 respiratory system MP:0005388 9.81 AGGF1 COL3A1 F2 FOXC2 HIF1A MMP2
11 skeleton MP:0005390 9.61 F2 FOXC2 HIF1A MMP2 MMP3 MMP9
12 vision/eye MP:0005391 9.23 FOXC2 HIF1A MMP2 MMP7 MMP9 MTHFR

Drugs & Therapeutics for Varicose Veins

PubMed Health treatment related to Varicose Veins: 63

Varicose veins are treated with lifestyle changes and medical procedures. The goals of treatment are to relieve symptoms, prevent complications, and improve appearance. If varicose veins cause few symptoms, your doctor may simply suggest making lifestyle changes. If your symptoms are more severe, your doctor may recommend one or more medical procedures. For example, you may need a medical procedure if you have a lot of pain, blood clots, or skin disorders caused by your varicose veins. Some people who have varicose veins choose to have procedures to improve how their veins look. Although treatment can help existing varicose veins, it can't keep new varicose veins from forming.

Drugs for Varicose Veins (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 257)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
2
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
3
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
4
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
5
Cefoxitin Approved Phase 4 35607-66-0 441199
6
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
7
Cefotaxime Approved Phase 4 63527-52-6 456256 5742673
8
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
9
Azithromycin Approved Phase 4 83905-01-5 447043 55185
10
Vancomycin Approved Phase 4 1404-90-6 441141 14969
11 Ethiodized oil Approved, Investigational Phase 4 8008-53-5
12
Ethanolamine oleate Approved Phase 4 2272-11-9
13
Somatostatin Approved, Investigational Phase 4 38916-34-6, 51110-01-1 53481605
14
Thrombin Approved, Investigational Phase 4
15
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
16
Dalteparin Approved Phase 4 9005-49-6
17
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
18
Ibuprofen Approved Phase 4 15687-27-1 3672
19
Nitric Oxide Approved Phase 4 10102-43-9 145068
20
Isosorbide Dinitrate Approved, Investigational Phase 4 87-33-2 6883
21
AT-101 Approved, Investigational Phase 4 90141-22-3, 652-67-5 12597
22
Warfarin Approved Phase 4 81-81-2 6691 54678486
23
Prazosin Approved Phase 4 19216-56-9 4893
24
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
25
Phylloquinone Approved, Investigational Phase 4 84-80-0
26
Acenocoumarol Approved, Investigational Phase 4 152-72-7 9052 54676537
27 Bemiparin Approved, Investigational Phase 4 91449-79-5
28
Octreotide Approved, Investigational Phase 4 83150-76-9 383414 6400441
29
Terlipressin Approved, Investigational Phase 4 14636-12-5 72081
30
Pantoprazole Approved Phase 4 102625-70-7 4679
31
Tranexamic Acid Approved Phase 4 1197-18-8 5526
32
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
33
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
34
Racepinephrine Approved Phase 4 329-65-7 838
35
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
36
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
37
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 22737-96-8, 11103-57-4, 68-26-8 9904001 445354
38
Menadione Approved, Nutraceutical Phase 4 58-27-5 4055
39 Menaquinone Investigational Phase 4 1182-68-9
40 Neurotransmitter Agents Phase 4
41 Anti-Arrhythmia Agents Phase 4
42 Anti-Bacterial Agents Phase 4
43 Antibiotics, Antitubercular Phase 4
44 Antitubercular Agents Phase 4
45 Anti-Infective Agents Phase 4
46 Anesthetics, General Phase 4
47 Anesthetics, Intravenous Phase 4
48 Hypnotics and Sedatives Phase 4
49 Tranquilizing Agents Phase 4
50 Anti-Anxiety Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 423)
# Name Status NCT ID Phase Drugs
1 The Impact of Early Feeding Following Ligation of the Acute Bleeding Varices Unknown status NCT01287702 Phase 4
2 Banding Ligation Plus Propranolol Versus Banding Ligation to Prevent Rebleeding of Esophageal Varices Unknown status NCT02740166 Phase 4 propranolol
3 Endoscopic Treatment Versus Propranolol for Primary Prevention of Patients With Hepatocellular Carcinoma and Concomitant Esophageal Varices Unknown status NCT01970748 Phase 4 Propranolol
4 Compression Versus Anti-Embolism Stockings in Patients With Leg Edema: Objective Investigation of Interface Compression and Edema Measurements, Clinical Outcomes, and Quality of Life. Unknown status NCT00766974 Phase 4
5 RCT of Carvedilol vs Variceal Band Ligation in the Primary Prophylaxis of Oesophageal Variceal Haemorrhage Unknown status NCT01070641 Phase 4 Carvedilol
6 Primary Prophylaxis of High-risk Esophageal Gastric Variceal Bleeding Comparing Carvedilol and Endoscopic Therapy: A Multicenter Randomized Controlled Trial Unknown status NCT02695732 Phase 4 Carvedilol
7 A Randomized Trial of GVS Alone vs. Nadolol Unknown status NCT01298271 Phase 4 propranolol
8 Endoscopic Treatment Alone Versus Combined Propranolol and Endoscopic Treatment of Acute Variceal Hemorrhage in Patients With Hepatocellular Carcinoma Unknown status NCT01451658 Phase 4 propranolol
9 The Effect of Carvedilol Vs Propranolol in Patients With Cirrhosis Related Esophagogastric Varices After Multiple Endoscopic Treatments For Secondary Prophylaxis:A Randomized Controlled Trial Unknown status NCT02385422 Phase 4 Carvedilol;Propranolol
10 Randomized and Controlled Study of Endoscopic Ligation, Nadolol and Isosorbide Mononitrate vs Endoscopic Ligation and Nadolol Alone, or Associated With Isosorbide Mononitrate or Prazosin, Depending of the Hemodinamyc Response Unknown status NCT00563602 Phase 4
11 Banding Ligation With Carvedilol vs. Carvedilol for the Prevention of First Bleeding in Cirrhotics With Moderate Varices Unknown status NCT01383044 Phase 4 carvedilol
12 Prevention of Progression of Portal Hypertension in Compensated Cirrhosis Using Selective Hepatic Vasodilators. A Double-blind, Multicenter,Randomized Controlled Trial Unknown status NCT01282398 Phase 4 Simvastatin;placebo
13 The Effect of HVPG-Guided Individualized Therapy in Patients With Cirrhosis Related Esophagogastric Variceal Hemorrhage For Secondary Prophylaxis:A Randomized Controlled Trial Unknown status NCT02638415 Phase 4 Carvedilol
14 Randomized Controlled Trial Comparing Effects of Sedation for Upper Gastrointestinal Endoscopy With Propofol Versus Midazolam on Psychometric Tests and Critical Flicker Frequency in Cirrhotics Unknown status NCT01356121 Phase 4 Propofol;Midazolam
15 Prevention of Esophageal Variceal Rebleeding Unknown status NCT00863837 Phase 4 terlipressin (vasoconstrictor);pantoloc (proton pump inhibitor)
16 A Randomized Tril of Endoscopic Cyanoacrylate Obliteration vs. Nadolol Unknown status NCT00567216 Phase 4 Nadolol
17 Prospective, Randomized Trial of Hemospray Plus Epinephrine Injection Versus Endoscopic Hemoclip Plus Epinephrine Injection in Nonvariceal Upper Gastrointestinal Bleeding Unknown status NCT02537353 Phase 4 Hemospray;Adrenaline
18 Bacterial Infections Associated With Healthcare (Healthcare-Associated) in Hospitalized Cirrhotic Patients: Randomized Study of Use of Traditional Empirical Antibiotic Therapy and Second-line Targeted at Multi-resistant Bacteria Unknown status NCT01820026 Phase 4 Imipenem;Vancomycin;azithromycin;Cefotaxime;Amoxicillin
19 PROPRANOLOL ASSOCIATED WITH ENDOSCOPIC BAND LIGATION REDUCES RECURRENCE OF ESOPHAGEAL VARICES FOR PRIMARY PROPHYLAXIS OF VARICEAL BLEEDING?: A RANDOMIZED CONTROLLED TRIAL Completed NCT01893541 Phase 4 PROPRANOLOL
20 Multicenter Study to Evaluate Pain Following Treatment of Varicose Vein With Varithena® Compared to Radiofrequency Ablation Completed NCT02462720 Phase 4 Varithena®
21 Evaluate the Efficacy and Safety of Esarin Gel in the Treatment of Chronic Venous Insufficiency or Varicose Vein Combine With Superficial Vein Thrombophlebitis in Outpatient Completed NCT02346058 Phase 4 Esarin Gel
22 Comparison of Endoscopic Injection of Conventional and Double Doses Cyanoacrylate for Gastric Variceal Hemorrhage Completed NCT00735358 Phase 4
23 Comparison of Surgery Versus Foam Sclerotherapy for Isolated Accessory Great Saphenous Vein Varicosis Completed NCT02010723 Phase 4 sclerotherapy with aethoxysclerol foam
24 Efficacy of Alkalinised 2% Mepivacaine for Local Infiltration Anesthesia, in Ambulatory Phlebectomy Completed NCT01611324 Phase 4 Mepivacaine chlorhydrate 2% in Sodium Bicarbonate 1.4%;Mepivacaine chlorhydrate 2% with epinephrine in NS 0.9%
25 Radiofrequency Endovenous ClosureFAST vs. Laser Ablation for the Treatment of Great Saphenous Reflux: A Multicenter, Single-Blinded, Randomized Study (RECOVERY) Completed NCT00509392 Phase 4
26 Polidocanol Versus Glucose For Sclerotherapy Treatment Of Telangiectasia Of The Lower Limbs: Protocol For A Randomized, Controlled Clinical Trial Completed NCT02657252 Phase 4 Glucose;Polidocanol with Glucose
27 A Randomized Triple-blind Study Protocol Comparing Polidocanol Versus Hypertonic Glucose for Sclerotherapy in Treatment of Reticular Veins at the Lower Limbs. Completed NCT02054325 Phase 4 Polidocanol with Glucose;Glucose
28 Short-course Somatostatin Versus Terlipressin Infusion in Combination With Endoscopic Variceal Ligation for the Prevention of Early Esophageal Variceal Rebleeding Completed NCT02757703 Phase 4 Somatostatin;Terlipressin;Pantoprazole
29 RCT for the Effect of Early Administration of Vasoactive Substances When Combined With Endoscopic Treatment in Acute Gastro-esophageal Variceal Bleeds: Comparisons Among Terlipressin, Somatostatin, and Octreotide Completed NCT00966355 Phase 4 Terlipressin;Somatostatin;Octreotide
30 Endoscopic Treatment of Esophageal Varices in Advanced Liver Disease Patients: a Randomized Controlled Trial Comparing Band Ligation and Cyanoacrylate Injection Completed NCT00799851 Phase 4 cyanoacrylate injection
31 Appropriate Time Interval for Repeat Sessions of Endoscopic Ligation for the Eradication of Esophageal Varices Completed NCT01291277 Phase 4
32 Management of Superficial Thrombophlebitis Completed NCT00264381 Phase 4 Dalteparin sodium injection
33 Radiofrequency Ablation vs Laser Ablation of the Incompetent Greater Saphenous Vein: A Prospective Randomized Trial Completed NCT02236338 Phase 4
34 Hemodynamic Effects of Terlipressin and High Dose Octreotide on Patients With Liver Cirrhosis Related Esophageal Varices: A Randomized, Placebo-controlled Multicenter Trial Completed NCT02119884 Phase 4 Terlipressin;Octreotide
35 A Controlled Trial of Nadolol Plus Isosorbide Mononitrate vs. Carvedilol for the Prevention of Variceal Rebleeding Completed NCT01103154 Phase 4 carvedilol;nadolol + ISMN
36 A Randomized, Controlled Trial of Ligation Plus Nadolol Versus Nadolol Alone in the Prophylaxis of First Variceal Bleeding in Cirrhosis Completed NCT00921349 Phase 4 Nadolol
37 Carvedilol Plus Endoscopic Cyanoacrylate Injection Versus Endoscopic Cyanoacrylate Injection for Secondary Prophylaxis of Gastric Variceal Bleeding Completed NCT02504723 Phase 4 carvedilol;cyanoacrylate
38 Multicenter, Randomized, Double-blind, Placebo-controlled Study on the Effectiveness of Treatment With Beta-blockers to Prevent Decompensation of Cirrhosis With Portal Hypertension Completed NCT01059396 Phase 4 propranolol;carvedilol;placebo
39 A Clinical Trial of the Vessel Sealing System (LigaSure) in Azygoportal Disconnection and Splenectomy in Patients With Portal Hypertension Completed NCT00965744 Phase 4
40 A Randomized, Controlled, Multicentric Trial Comparing Endoscopic Band Ligation Versus Ransjugular Intrahepatic Portosystemic Stent Shunt in Cirrhotic Patients With Recurrent Variceal Bleeding Non Responding to Medical Therapy Completed NCT00570973 Phase 4
41 Secondary Prophylaxis After Variceal Bleeding: Combined Treatment With Endoscopic Ligation and Nadolol Against Nadolol Associated With Mononitrate of Isosorbide or Prazosin According to Hemodynamic Response. Completed NCT00450164 Phase 4 Nadolol;Isosorbide mononitrate;Prazosin
42 Randomized Double Blind Dummy Controlled Trial Of 24 Versus 72 Hours Of Terlipressin As An Adjuvant Therapy In Acute Variceal Bleed Completed NCT00369694 Phase 4 Terlipressin;Terlipressin & then Dummy
43 Clinically-Important Venous Thromboembolism Following Lower Extremity Fractures: Epidemiology & Prevention Completed NCT00187408 Phase 4 Low Molecular Weight Heparin (dalteparin)
44 Comparison of 3 Days and 7 Days Intravenous Ceftriaxone Prophylaxis in Patients With Acute Variceal Bleeding Completed NCT00838864 Phase 4 ceftrioxone;ceftrioxone
45 A Randomized, Controlled Trial of Ligation Plus Vasoconstrictor vs.Ligation Plus Proton Pump Inhibitor in the Control of Acute Esophageal Variceal Bleeding Completed NCT01112852 Phase 4 pantoloc 40 mg;somatostatin or terlipressin
46 Efficacy And Safety Of Terlipressin Vs Octreotide As Adjuvant Therapy In Bleeding Esophageal Varices Completed NCT00534677 Phase 4 Terlipressin;Octreotide
47 Ivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan Completed NCT02241044 Phase 4
48 Randomized Controlled Trial to Compare Treatment With Oral Anticoagulation With Antagonists of vitaminK vs Low Molecular Weight Heparin(Bemiparin) in Patients With Anticoagulation Criteria and an Episode of Gastrointestinal Bleeding. Completed NCT01727453 Phase 4 warfarin;Bemiparina
49 Comparison of 24-hours Versus 72-hours of Octreotide Infusion Along With Endoscopic Therapy in Preventing Early Rebleed From Esophageal Varices: a Multi-center, Randomized Clinical Study Recruiting NCT03624517 Phase 4 Octreotide
50 RCT Comparing the Efficacies of Endoscopic Band Ligation (EBL) and Combined Treatment of Beta-blocker and EBL for the Prevention of Esophageal Variceal Rebleeding in Patients With Previous Endoscopic Variceal Treatment Recruiting NCT00966082 Phase 4

Search NIH Clinical Center for Varicose Veins

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Balsam of Peru
Pentoxifylline
Polidocanol
Sodium Morrhuate
Sodium Tetradecyl Sulfate

Cochrane evidence based reviews: varicose veins

Genetic Tests for Varicose Veins

Anatomical Context for Varicose Veins

MalaCards organs/tissues related to Varicose Veins:

41
Liver, Spleen, Colon, Skin, Testes, Heart, Lung

Publications for Varicose Veins

Articles related to Varicose Veins:

(show top 50) (show all 19201)
# Title Authors PMID Year
1
Linkage to the FOXC2 region of chromosome 16 for varicose veins in otherwise healthy, unselected sibling pairs. 38 8
15744037 2005
2
A contribution to the problem of the inheritance of primary varicose veins. 38 8
4435791 1974
3
Genetics of varicose veins of the lower extremities. 38 8
5365895 1969
4
Therapies of varicose veins: Protocol for the reporting and methodological quality of pairwise meta-analyses. 38 17
31232937 2019
5
Pelvic congestion syndrome - treatment with pelvic varicose veins embolization. 38 17
31066803 2019
6
Familiar congenital absence of valves in the deep leg veins. 8
4426629 1974
7
The heredity of venous insufficiency. 8
13561707 1958
8
Therapeutic potential of natural compounds in inflammation and chronic venous insufficiency. 17
31096120 2019
9
Haemoptysis and bronchial congestion due to pulmonary vein stenosis after maze procedure. 38
31417676 2019
10
Thromboelastography Parameters Are Associated with Cirrhosis Severity. 38
30915655 2019
11
Long term outcome after minimally invasive and open Warshaw and Kimura techniques for spleen-preserving distal pancreatectomy: International multicenter retrospective study. 38
31005470 2019
12
In-office procedures for the treatment of benign vocal fold lesions in the awake patient: A contemporary review. 38
30575043 2019
13
Application of the Hepatic Transit Time (HTT) in Evaluation of Portal Vein Pressure in Gastroesophageal Varices Patients. 38
30609088 2019
14
Role of Spleen Stiffness Measurement by 2D-Shear Wave Elastography in Ruling Out the Presence of High-Risk Varices in Cirrhotic Patients. 38
30989464 2019
15
Novel endoscopic treatment strategy for early esophageal cancer in cirrhotic patients with esophageal varices. 38
31402951 2019
16
Efficacy of Endovenous Laser Treatment Combined with Sclerosing Foam in Treating Varicose Veins of the Lower Extremities. 38
31240628 2019
17
Endovenous cyanoacrylate glue to treat varicose veins and chronic venous insufficiency-Experience gained from our first 100+ truncal venous ablations in a multi-ethnic Asian population using the Medtronic VenaSeal™ Closure System. 38
30691376 2019
18
Effects of 1064-nm Nd:YAG long-pulse laser on polidocanol microfoam injected for varicose vein treatment: a controlled observational study of 404 legs, after 5-year-long treatment. 38
30707327 2019
19
The current knowledge about the therapeutic use of endoscopic sclerotherapy and endoscopic tissue adhesives in variceal bleeding. 38
31389265 2019
20
Octreotide Added to a Proton Pump Inhibitor Versus a Proton Pump Inhibitor Alone in Nonvariceal Upper-Gastrointestinal Bleeds. 38
30803243 2019
21
Statin Use Is Associated With Improved Outcomes of Patients With Primary Sclerosing Cholangitis. 38
30448601 2019
22
Laparoscopic Total Devascularization of the Upper Stomach and Splenectomy (Hassab's Procedure) Under Indocyanine Green Fluorescence Imaging: Initial Experience. 38
30734640 2019
23
[Esophageal variceal bleeding: management and tips on transjugular intrahepatic portosystemic shunt]. 38
30963209 2019
24
Evaluation of three "beyond Baveno VI" criteria to safely spare endoscopies in compensated advanced chronic liver disease. 38
30691777 2019
25
Acute pericarditis: A rare complication of gastric variceal obturation with cyanoacrylate glue. 38
31401042 2019
26
Multiparametric ultrasound in liver diseases: an overview for the practising clinician. 38
30665903 2019
27
Importance of Multislice Computed Tomography in Determining the Severity of Chronic Liver Disease State. 38
31402246 2019
28
Machine Learning-based Development and Validation of a Scoring System for Screening High-Risk Esophageal Varices. 38
30708109 2019
29
Ulcer bleeding after band ligation of esophageal varices: Risk factors and prognosis. 38
31395524 2019
30
Is Transient Elastography Needed for Noninvasive Assessment of High-Risk Varices? The REAL Experience. 38
31135449 2019
31
Clip-assisted endoscopic cyanoacrylate injection for gastric varices with a gastrorenal shunt: a multicenter study. 38
31378856 2019
32
Coexistence of "extra-gastric afferent-efferent direct connection" with gastric varices: CT evaluation and clinical significance. 38
31030246 2019
33
Intraabdominal Hemorrhage from Ruptured Ectopic Varices Treated by Antegrade Embolization via a Recanalized Paraumbilical Vein. 38
31073821 2019
34
Endoscopic sclerotherapy under balloon-assisted enteroscopy for hemorrhagic jejunal varices after choledocho-jejunostomy. 38
31434157 2019
35
Occipital Sinus Dural Arteriovenous Fistula Presenting with Cerebellar Hemorrhage: A Case Report. 38
31398518 2019
36
The role of multislice computerized tomography angiography in assessing postoperative vascular complications in liver transplant patients 38
31385486 2019
37
Etiology, presenting features and outcome of children with non-cirrhotic portal vein thrombosis: A multicentre national study. 38
30928422 2019
38
Effect of laparoscopic splenectomy on portal vein thrombosis and serum YKL-40 in patients with cirrhotic portal hypertension. 38
31427175 2019
39
The role of multislice computerized tomography angiography in assessing postoperative vascular complications in liver transplant patients 38
31408295 2019
40
Combination therapy versus monotherapy for EUS-guided management of gastric varices: A systematic review and meta-analysis. 38
31417066 2019
41
Editorial: screening for oesophageal varices after directly acting anti-viral therapy-do not let your guard down. 38
31359476 2019
42
Non-endoscopic predictors of esophageal varices in children with chronic liver disease and their utility in resource-constrained countries. 38
31423562 2019
43
Long-term outcome of HCC occurrence, esophageal varices exacerbation and mortality in hepatitis C virus-related liver cirrhosis after interferon-based therapy. 38
31373093 2019
44
Correction to: Liaoning Score for Prediction of Esophageal Varices in Cirrhotic Patients Who Had Never Undergone Endoscopy: A Multicenter Cross-Sectional Study in Liaoning Province, China. 38
31236850 2019
45
Liaoning Score for Prediction of Esophageal Varices in Cirrhotic Patients Who Had Never Undergone Endoscopy: A Multicenter Cross-Sectional Study in Liaoning Province, China. 38
31093864 2019
46
Performance of Baveno VI and Expanded Baveno VI Criteria for Excluding High-Risk Varices in Patients With Chronic Liver Diseases: A Systematic Review and Meta-analysis. 38
31077823 2019
47
Double-balloon enteroscopy-facilitated cyanoacrylate-injection endotherapy of small-bowel varices: an international experience from 2 European tertiary centers (with videos). 38
30980796 2019
48
Penile prosthesis implant for primary erectile dysfunction in patient with Klippel-Trenaunay syndrome complicated by consumptive coagulopathy: A case report. 38
31393387 2019
49
Peptide growth factors and their receptors in the vein wall. 38
31427387 2019
50
Fatal rooster attack. 38
31432454 2019

Variations for Varicose Veins

ClinVar genetic disease variations for Varicose Veins:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 ELN NM_000501.4(ELN): c.898A> T (p.Thr300Ser) single nucleotide variant Uncertain significance rs766735416 7:73466262-73466262 7:74051932-74051932

Expression for Varicose Veins

Search GEO for disease gene expression data for Varicose Veins.

Pathways for Varicose Veins

Pathways related to Varicose Veins according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.37 VEGFA MMP9 MMP7 MMP3 MMP2 MMP1
2
Show member pathways
13.33 VWF VEGFA TIMP1 MMP9 MMP3 MMP2
3
Show member pathways
13.27 VWF VEGFA TIMP1 SERPINC1 MMP1 F5
4 12.78 VEGFA MMP9 MMP2 MMP1 HIF1A
5
Show member pathways
12.76 SERPINC1 MMP9 MMP7 MMP3 F5 F2
6
Show member pathways
12.63 TIMP2 TIMP1 MMP9 MMP7 MMP3 MMP2
7 12.25 VEGFA MMP9 MMP2 HIF1A
8
Show member pathways
12.25 VEGFA TIMP1 MMP3 MMP1 HIF1A
9
Show member pathways
12.2 MMP9 MMP7 MMP3 MMP2 MMP1 F2
10 12.14 VEGFA MMP9 MMP7 MMP2 MMP1
11
Show member pathways
12.13 VWF SERPINC1 F5 F2
12 12.07 VWF SERPINC1 F5 F2
13
Show member pathways
12.01 MMP9 MMP7 MMP3 MMP2 F2
14 11.88 VEGFA TIMP1 HIF1A
15 11.86 VEGFA TIMP1 MMP9 MMP3 MMP2 MMP1
16 11.84 VEGFA MMP2 COL3A1
17 11.8 VEGFA MMP3 MMP1
18 11.72 VEGFA MMP9 MMP2 MMP1
19
Show member pathways
11.7 TIMP2 TIMP1 MMP9 MMP7 MMP3 MMP2
20 11.67 MMP9 MMP7 MMP2 HIF1A
21 11.64 TIMP1 MMP9 MMP2 ELN
22
Show member pathways
11.6 VEGFA MMP9 MMP3 MMP2 MMP1
23 11.52 VWF F2 COL3A1
24 11.52 VEGFA MMP1 HIF1A
25 11.51 VWF TIMP2 TIMP1 MMP9 MMP7 MMP3
26 11.36 TIMP2 MMP9 MMP3 MMP1 ELN
27 11.32 MMP9 MMP2 MMP1
28
Show member pathways
11.26 VEGFA TIMP1 HIF1A
29 11.18 TIMP2 TIMP1 MMP9 F2
30 11.14 VEGFA TIMP2 MMP9 HIF1A
31 11.09 MMP2 MMP1 F2
32 11.04 VEGFA TIMP1 MMP1
33 11.01 TIMP2 TIMP1 MMP9 MMP7 MMP3 MMP2
34 10.97 MMP9 MMP7 MMP1
35 10.6 VEGFA HIF1A

GO Terms for Varicose Veins

Cellular components related to Varicose Veins according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 VWF VEGFA TIMP2 TIMP1 SHBG SERPINC1
2 endoplasmic reticulum lumen GO:0005788 9.77 TIMP1 SERPINC1 F5 F2 COL3A1
3 collagen-containing extracellular matrix GO:0062023 9.7 VWF TIMP2 SERPINC1 MMP9 MMP2 ELN
4 platelet alpha granule lumen GO:0031093 9.62 VWF VEGFA TIMP1 F5
5 platelet alpha granule GO:0031091 9.4 VWF F5
6 extracellular matrix GO:0031012 9.32 VEGFA TIMP2 TIMP1 MMP9 MMP7 MMP3
7 extracellular space GO:0005615 10 VEGFA TIMP2 TIMP1 SERPINC1 MMP9 MMP7

Biological processes related to Varicose Veins according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.91 VEGFA MMP2 HIF1A AGGF1
2 extracellular matrix organization GO:0030198 9.9 VWF MMP9 ELN COL3A1
3 blood coagulation GO:0007596 9.86 VWF SERPINC1 F5 F2
4 positive regulation of endothelial cell proliferation GO:0001938 9.78 VEGFA HIF1A AGGF1
5 response to hormone GO:0009725 9.75 TIMP2 TIMP1 FOXC2
6 response to cytokine GO:0034097 9.74 TIMP2 TIMP1 COL3A1
7 cellular protein metabolic process GO:0044267 9.73 TIMP1 SERPINC1 MMP2 MMP1 F5 F2
8 outflow tract morphogenesis GO:0003151 9.72 VEGFA HIF1A ELN
9 blood vessel development GO:0001568 9.71 HIF1A FOXC2 COL3A1
10 platelet degranulation GO:0002576 9.71 VWF VEGFA TIMP1 F5
11 cytokine-mediated signaling pathway GO:0019221 9.7 VEGFA TIMP1 MMP9 MMP3 MMP2 MMP1
12 response to hypoxia GO:0001666 9.67 VEGFA MTHFR MMP2 HIF1A
13 lactation GO:0007595 9.65 VEGFA SERPINC1 HIF1A
14 positive regulation of protein oligomerization GO:0032461 9.62 MMP3 MMP1
15 regulation of blood coagulation GO:0030193 9.62 SERPINC1 F2
16 hemostasis GO:0007599 9.62 VWF SERPINC1 F5 F2
17 blood circulation GO:0008015 9.61 MTHFR F5 ELN
18 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.59 TIMP2 TIMP1
19 regulation of neuroinflammatory response GO:0150077 9.52 MMP9 MMP3
20 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.51 VEGFA HIF1A
21 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.49 TIMP1 HIF1A
22 negative regulation of metallopeptidase activity GO:1905049 9.46 TIMP2 TIMP1
23 collagen catabolic process GO:0030574 9.35 MMP9 MMP7 MMP3 MMP2 MMP1
24 extracellular matrix disassembly GO:0022617 9.17 TIMP2 TIMP1 MMP9 MMP7 MMP3 MMP2
25 proteolysis GO:0006508 10.06 MMP9 MMP7 MMP3 MMP2 MMP1 F2

Molecular functions related to Varicose Veins according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.87 TIMP2 TIMP1 MMP9 MMP7 MMP3 MMP2
2 peptidase activity GO:0008233 9.85 MMP9 MMP7 MMP3 MMP2 MMP1 F2
3 heparin binding GO:0008201 9.71 VEGFA SERPINC1 MMP7 F2
4 metallopeptidase activity GO:0008237 9.65 MMP9 MMP7 MMP3 MMP2 MMP1
5 endopeptidase activity GO:0004175 9.63 MMP9 MMP3 MMP1
6 serine-type endopeptidase activity GO:0004252 9.63 MMP9 MMP7 MMP3 MMP2 MMP1 F2
7 metalloendopeptidase inhibitor activity GO:0008191 9.48 TIMP2 TIMP1
8 metalloendopeptidase activity GO:0004222 9.35 MMP9 MMP7 MMP3 MMP2 MMP1
9 protease binding GO:0002020 9.02 VWF TIMP2 TIMP1 SERPINC1 COL3A1
10 protein binding GO:0005515 10.36 VWF VEGFA TIMP2 TIMP1 SHBG SERPINC1

Sources for Varicose Veins

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....