VARIX
MCID: VRC005
MIFTS: 60

Varicose Veins (VARIX)

Categories: Blood diseases, Cardiovascular diseases, Skin diseases

Aliases & Classifications for Varicose Veins

MalaCards integrated aliases for Varicose Veins:

Name: Varicose Veins 57 12 6 42 44 15 62 62
Varices 12 15
Venous Ectasia 12
Venous Varices 12
Varicosity 71
Varix 12

Characteristics:

OMIM®:

57 (Updated 05-Mar-2021)
Inheritance:
multifactorial vs. autosomal or x-linked dominant


HPO:

31

Classifications:



External Ids:

Disease Ontology 12 DOID:799
OMIM® 57 192200
MeSH 44 D014648
NCIt 50 C35114
SNOMED-CT 67 276504003
ICD10 32 I83.90
MedGen 41 C0042345
SNOMED-CT via HPO 68 128060009 12856003 399989005
UMLS 71 C0042345

Summaries for Varicose Veins

MedlinePlus : 42 Varicose veins are swollen, twisted veins that you can see just under the skin. They usually occur in the legs, but also can form in other parts of the body. Hemorrhoids are a type of varicose vein. Your veins have one-way valves that help keep blood flowing toward your heart. If the valves are weak or damaged, blood can back up and pool in your veins. This causes the veins to swell, which can lead to varicose veins. Varicose veins are very common. You are more at risk if you are older, are female, have obesity, don't exercise, or have a family history of varicose veins. They can also be more common in pregnancy. Doctors often diagnose varicose veins from a physical exam. Sometimes you may need additional tests. Exercising, losing weight, elevating your legs when resting, and not crossing them when sitting can help keep varicose veins from getting worse. Wearing loose clothing and avoiding long periods of standing can also help. If varicose veins are painful or you don't like the way they look, your doctor may recommend procedures to remove them. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Varicose Veins, also known as varices, is related to klippel-trenaunay-weber syndrome and pelvic varices, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Varicose Veins is ELN (Elastin), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Midazolam and Ketorolac have been mentioned in the context of this disorder. Affiliated tissues include liver, spleen and heart, and related phenotypes are varicose veins and homeostasis/metabolism

Disease Ontology : 12 A vein disease that is characterized by swollen, twisted veins visible just under the surface of the skin.

PubMed Health : 62 About varicose veins: Varicose (VAR-i-kos) veins are swollen, twisted veins that you can see just under the surface of the skin. These veins usually occur in the legs, but they also can form in other parts of the body. Varicose veins are a common condition. They usually cause few signs and symptoms. Sometimes varicose veins cause mild to moderate pain, blood clots, skin ulcers (sores), or other problems.

Wikipedia : 74 Varicose veins, also known as varicoses, are a medical condition in which superficial veins become... more...

More information from OMIM: 192200

Related Diseases for Varicose Veins

Diseases related to Varicose Veins via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 899)
# Related Disease Score Top Affiliating Genes
1 klippel-trenaunay-weber syndrome 32.7 FOXC2 F2 AGGF1
2 pelvic varices 32.0 TNF SHBG IL6
3 budd-chiari syndrome 32.0 SERPINC1 MTHFR F2
4 varicocele 31.9 TNF SHBG MTHFR IL6 HIF1A
5 venous insufficiency 31.6 VWF VEGFA TIMP1 MTHFR MMP9 MMP1
6 chronic venous insufficiency 31.6 VEGFA TIMP2 TIMP1 MTHFR MMP9 MMP1
7 thrombophlebitis 31.6 VWF SERPINC1 MTHFR F2
8 lipodermatosclerosis 31.4 VEGFA TIMP2 MMP1
9 portal hypertension 31.3 VWF VEGFA TNF F2 ELN
10 post-thrombotic syndrome 31.2 SERPINC1 IL6 F2
11 hemorrhoid 31.2 TNF MMP9 F2
12 pulmonary embolism 31.2 VWF SERPINC1 MTHFR F2
13 thrombosis 31.2 VWF SERPINC1 MTHFR F2
14 thrombophilia due to thrombin defect 31.1 VWF SERPINC1 MTHFR F2
15 vascular disease 31.0 VWF VEGFA TNF TIMP1 SERPINC1 MTHFR
16 cellulitis 30.9 TNF IL6 F2
17 gastric ulcer 30.9 TNF MMP9 IL6
18 thrombophilia 30.8 VWF SERPINC1 MTHFR F2
19 inguinal hernia 30.7 TIMP2 TIMP1 MMP9 MMP2 MMP1 IL6
20 liver cirrhosis 30.7 VEGFA TNF TIMP2 TIMP1 SERPINC1 IL6
21 pyoderma 30.7 TNF MMP9 MMP1
22 pyoderma gangrenosum 30.7 TNF MMP9 MMP1
23 patent foramen ovale 30.6 VWF SERPINC1 MTHFR F2
24 hemangioma 30.6 VWF VEGFA MMP9 HIF1A F2
25 portal vein thrombosis 30.6 SERPINC1 MTHFR F2
26 fasciitis 30.6 TNF MMP1 IL6
27 mitral valve disease 30.6 MMP1 F2 ELN
28 alcoholic liver cirrhosis 30.5 TNF IL6 F2
29 sclerosing cholangitis 30.5 TNF IL6 F2
30 cutis laxa 30.5 MMP9 MMP3 MMP2 ELN
31 vein disease 30.5 VWF VEGFA TNF SERPINC1 MTHFR MIR202
32 aspiration pneumonia 30.4 TNF IL6 F2
33 arteriovenous malformation 30.4 VEGFA MMP9 IL6
34 mitral valve stenosis 30.4 VWF SERPINC1 F2
35 factor viii deficiency 30.4 VWF SERPINC1 F2
36 obstructive jaundice 30.4 TNF IL6 F2
37 intraocular pressure quantitative trait locus 30.4 VEGFA TIMP2 MMP1 FOXC2 ELN
38 protein c deficiency 30.3 SERPINC1 MTHFR F2
39 aortic aneurysm 30.3 TIMP1 MMP9 MMP2 IL6 ELN
40 placental abruption 30.3 SERPINC1 MTHFR F2
41 adult respiratory distress syndrome 30.2 TNF IL6 F2 ELN
42 meningitis 30.2 VEGFA TNF MMP9 IL6
43 intracranial embolism 30.2 VWF SERPINC1 F2
44 hepatic encephalopathy 30.2 TNF MMP9 IL6 F2
45 atrial heart septal defect 30.2 SERPINC1 MTHFR F2 ELN
46 intravascular papillary endothelial hyperplasia 30.2 VEGFA HIF1A
47 exanthem 30.2 VEGFA TNF IL6 F2
48 giant hemangioma 30.2 SERPINC1 F2
49 relapsing-remitting multiple sclerosis 30.2 TNF TIMP1 MMP9 IL6
50 thrombophilia due to activated protein c resistance 30.2 VWF SERPINC1 MTHFR F2

Graphical network of the top 20 diseases related to Varicose Veins:



Diseases related to Varicose Veins

Symptoms & Phenotypes for Varicose Veins

Human phenotypes related to Varicose Veins:

31
# Description HPO Frequency HPO Source Accession
1 varicose veins 31 HP:0002619

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Mar-2021)
Vascular:
varicose veins

Misc:
twice as frequent in females as in males

Clinical features from OMIM®:

192200 (Updated 05-Mar-2021)

UMLS symptoms related to Varicose Veins:


angina pectoris, chest pain, edema

MGI Mouse Phenotypes related to Varicose Veins:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 F2 FOXC2 HIF1A IL6 MMP1 MMP2
2 cardiovascular system MP:0005385 10.27 AGGF1 F2 FOXC2 HIF1A IL6 MMP2
3 immune system MP:0005387 10.21 F2 FOXC2 HIF1A IL6 MMP1 MMP2
4 digestive/alimentary MP:0005381 10.03 F2 FOXC2 HIF1A IL6 MMP9 TNF
5 nervous system MP:0003631 10 AGGF1 F2 FOXC2 HIF1A IL6 MMP2
6 muscle MP:0005369 9.97 F2 FOXC2 HIF1A IL6 MMP2 MMP9
7 neoplasm MP:0002006 9.91 AGGF1 HIF1A IL6 MMP1 MMP2 MMP9
8 respiratory system MP:0005388 9.65 AGGF1 F2 FOXC2 HIF1A IL6 MMP2
9 skeleton MP:0005390 9.36 F2 FOXC2 HIF1A IL6 MMP2 MMP3

Drugs & Therapeutics for Varicose Veins

PubMed Health treatment related to Varicose Veins: 62

Varicose veins are treated with lifestyle changes and medical procedures. The goals of treatment are to relieve symptoms, prevent complications, and improve appearance. If varicose veins cause few symptoms, your doctor may simply suggest making lifestyle changes. If your symptoms are more severe, your doctor may recommend one or more medical procedures. For example, you may need a medical procedure if you have a lot of pain, blood clots, or skin disorders caused by your varicose veins. Some people who have varicose veins choose to have procedures to improve how their veins look. Although treatment can help existing varicose veins , it can't keep new varicose veins from forming.

Drugs for Varicose Veins (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 206)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
2
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
3
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
4
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
5
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
6
Nadolol Approved Phase 4 42200-33-9 39147
7
Somatostatin Approved, Investigational Phase 4 51110-01-1, 38916-34-6 53481605
8 Ethiodized oil Approved, Investigational Phase 4 8008-53-5
9
Ethanolamine oleate Approved Phase 4 2272-11-9
10
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
11
Pantoprazole Approved Phase 4 102625-70-7 4679
12
Rifaximin Approved, Investigational Phase 4 80621-81-4 6436173 46783403
13
Isosorbide Dinitrate Approved, Investigational Phase 4 87-33-2 6883
14
AT-101 Approved, Investigational Phase 4 90141-22-3, 652-67-5 12597
15
Nitric Oxide Approved Phase 4 10102-43-9 145068
16
Lactulose Approved Phase 4 4618-18-2 11333
17
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
18
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
19
Prazosin Approved Phase 4 19216-56-9 4893
20
Octreotide Approved, Investigational Phase 4 83150-76-9 383414 6400441
21
Terlipressin Approved, Investigational Phase 4 14636-12-5 72081
22
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
23
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
24
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
25
Racepinephrine Approved Phase 4 329-65-7 838
26
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
27
Ibuprofen Approved Phase 4 15687-27-1 3672
28
Hesperidin Approved, Investigational Phase 4 520-26-3 53477767
29
Aspartic acid Approved, Nutraceutical Phase 4 56-84-8 5960
30
Ornithine Approved, Nutraceutical Phase 4 70-26-8, 3184-13-2 6262
31 GABA Modulators Phase 4
32 Psychotropic Drugs Phase 4
33 Anti-Anxiety Agents Phase 4
34 Anti-Infective Agents Phase 4
35 Salicylates Phase 4
36 Hormone Antagonists Phase 4
37 N-Methylaspartate Phase 4
38 Antacids Phase 4
39 Anti-Ulcer Agents Phase 4
40 diuretics Phase 4
41 isosorbide-5-mononitrate Phase 4
42 Sympatholytics Phase 4
43 Gastrointestinal Agents Phase 4
44 Antineoplastic Agents, Hormonal Phase 4
45 Vasoconstrictor Agents Phase 4
46 Antibiotics, Antitubercular Phase 4
47 Anti-Bacterial Agents Phase 4
48 Proton Pump Inhibitors Phase 4
49 Anesthetics, Local Phase 4
50 Adrenergic alpha-Agonists Phase 4

Interventional clinical trials:

(show top 50) (show all 401)
# Name Status NCT ID Phase Drugs
1 The Impact of Early Feeding Following Ligation of the Acute Bleeding Varices Unknown status NCT01287702 Phase 4
2 Does the Preoperative Midazolam Dose Affect Postoperative Pain? - a Multicentric Randomized Controlled Trial in Ambulatory Surgery Unknown status NCT03534895 Phase 4 Midazolam Injectable Solution;Postoperative analgesia;Rescue analgesia;Wound infiltration;Analgesia at home
3 Banding Ligation Plus Propranolol Versus Banding Ligation to Prevent Rebleeding of Esophageal Varices Unknown status NCT02740166 Phase 4 propranolol
4 RCT of Carvedilol vs Variceal Band Ligation in the Primary Prophylaxis of Oesophageal Variceal Haemorrhage Unknown status NCT01070641 Phase 4 Carvedilol
5 The Effect of HVPG-Guided Individualized Therapy in Patients With Cirrhosis Related Esophagogastric Variceal Hemorrhage For Secondary Prophylaxis:A Randomized Controlled Trial Unknown status NCT02638415 Phase 4 Carvedilol
6 The Effect of Carvedilol Vs Propranolol in Patients With Cirrhosis Related Esophagogastric Varices After Multiple Endoscopic Treatments For Secondary Prophylaxis:A Randomized Controlled Trial Unknown status NCT02385422 Phase 4 Carvedilol;Propranolol
7 Primary Prophylaxis of High-risk Esophageal Gastric Variceal Bleeding Comparing Carvedilol and Endoscopic Therapy: A Multicenter Randomized Controlled Trial Unknown status NCT02695732 Phase 4 Carvedilol
8 Prevention of Esophageal Variceal Rebleeding Unknown status NCT00863837 Phase 4 terlipressin (vasoconstrictor);pantoloc (proton pump inhibitor)
9 Randomized and Controlled Study of Endoscopic Ligation, Nadolol and Isosorbide Mononitrate vs Endoscopic Ligation and Nadolol Alone, or Associated With Isosorbide Mononitrate or Prazosin, Depending of the Hemodinamyc Response Unknown status NCT00563602 Phase 4
10 Endoscopic Treatment Alone Versus Combined Propranolol and Endoscopic Treatment of Acute Variceal Hemorrhage in Patients With HCC:a Randomized Trial Unknown status NCT01298284 Phase 4 propranolol
11 A Randomized Triple-blind Study Protocol Comparing Polidocanol Versus Hypertonic Glucose for Sclerotherapy in Treatment of Reticular Veins at the Lower Limbs. Completed NCT02054325 Phase 4 Polidocanol with Glucose;Glucose
12 Polidocanol Versus Glucose For Sclerotherapy Treatment Of Telangiectasia Of The Lower Limbs: Protocol For A Randomized, Controlled Clinical Trial Completed NCT02657252 Phase 4 Glucose;Polidocanol with Glucose
13 Study of Antiinflammatory Effects of Detralex (Daflon) in Patients With Chronic Venous Disease Completed NCT01654016 Phase 4 Detralex
14 PROPRANOLOL ASSOCIATED WITH ENDOSCOPIC BAND LIGATION REDUCES RECURRENCE OF ESOPHAGEAL VARICES FOR PRIMARY PROPHYLAXIS OF VARICEAL BLEEDING?: A RANDOMIZED CONTROLLED TRIAL Completed NCT01893541 Phase 4 PROPRANOLOL
15 Comparison of Surgery Versus Foam Sclerotherapy for Isolated Accessory Great Saphenous Vein Varicosis Completed NCT02010723 Phase 4 sclerotherapy with aethoxysclerol foam
16 Multicenter Study to Evaluate Pain Following Treatment of Varicose Vein With Varithena® Compared to Radiofrequency Ablation Completed NCT02462720 Phase 4 Varithena®
17 Efficacy of Alkalinised 2% Mepivacaine for Local Infiltration Anesthesia, in Ambulatory Phlebectomy Completed NCT01611324 Phase 4 Mepivacaine chlorhydrate 2% in Sodium Bicarbonate 1.4%;Mepivacaine chlorhydrate 2% with epinephrine in NS 0.9%
18 Evaluate the Efficacy and Safety of Esarin Gel in the Treatment of Chronic Venous Insufficiency or Varicose Vein Combine With Superficial Vein Thrombophlebitis in Outpatient Completed NCT02346058 Phase 4 Esarin Gel
19 Short-course Somatostatin Versus Terlipressin Infusion in Combination With Endoscopic Variceal Ligation for the Prevention of Early Esophageal Variceal Rebleeding Completed NCT02757703 Phase 4 Somatostatin;Terlipressin;Pantoprazole
20 Comparison of Endoscopic Injection of Conventional and Double Doses Cyanoacrylate for Gastric Variceal Hemorrhage Completed NCT00735358 Phase 4
21 A Randomized, Controlled, Multicentric Trial Comparing Endoscopic Band Ligation Versus Ransjugular Intrahepatic Portosystemic Stent Shunt in Cirrhotic Patients With Recurrent Variceal Bleeding Non Responding to Medical Therapy Completed NCT00570973 Phase 4
22 Efficacy of Terlipressin Therapy in Acute Variceal Haemorrhage After Endoscopic Variceal Ligation: A Randomised Controlled Clinical Trial Completed NCT03584087 Phase 4 Normal Saline;Terlipressin
23 A Randomized, Controlled Trial of Ligation Plus Vasoconstrictor vs.Ligation Plus Proton Pump Inhibitor in the Control of Acute Esophageal Variceal Bleeding Completed NCT01112852 Phase 4 pantoloc 40 mg;somatostatin or terlipressin
24 Hemodynamic Effects of Terlipressin and High Dose Octreotide on Patients With Liver Cirrhosis Related Esophageal Varices: A Randomized, Placebo-controlled Multicenter Trial Completed NCT02119884 Phase 4 Terlipressin;Octreotide
25 Carvedilol Plus Endoscopic Cyanoacrylate Injection Versus Endoscopic Cyanoacrylate Injection for Secondary Prophylaxis of Gastric Variceal Bleeding Completed NCT02504723 Phase 4 carvedilol;cyanoacrylate
26 Comparison of 3 Days and 7 Days Intravenous Ceftriaxone Prophylaxis in Patients With Acute Variceal Bleeding Completed NCT00838864 Phase 4 ceftrioxone;ceftrioxone
27 Appropriate Time Interval for Repeat Sessions of Endoscopic Ligation for the Eradication of Esophageal Varices Completed NCT01291277 Phase 4
28 Efficacy And Safety Of Terlipressin Vs Octreotide As Adjuvant Therapy In Bleeding Esophageal Varices Completed NCT00534677 Phase 4 Terlipressin;Octreotide
29 Endoscopic Treatment of Esophageal Varices in Advanced Liver Disease Patients: a Randomized Controlled Trial Comparing Band Ligation and Cyanoacrylate Injection Completed NCT00799851 Phase 4 cyanoacrylate injection
30 A Randomized, Controlled Trial of Ligation Plus Nadolol Versus Nadolol Alone in the Prophylaxis of First Variceal Bleeding in Cirrhosis Completed NCT00921349 Phase 4 Nadolol
31 A Controlled Trial of Nadolol Plus Isosorbide Mononitrate vs. Carvedilol for the Prevention of Variceal Rebleeding Completed NCT01103154 Phase 4 carvedilol;nadolol + ISMN
32 RCT for the Effect of Early Administration of Vasoactive Substances When Combined With Endoscopic Treatment in Acute Gastro-esophageal Variceal Bleeds: Comparisons Among Terlipressin, Somatostatin, and Octreotide Completed NCT00966355 Phase 4 Terlipressin;Somatostatin;Octreotide
33 Effects of Different Omeprazole Dosing on Gastric pH in Non- Variceal Upper Gastrointestinal Bleeding: A Randomized Prospective Study Completed NCT03980496 Phase 4 Omeprazole
34 Evaluation Of The Efficacy, Tolerance And Acceptability Of URGO Dressing 310 3082 Versus A Hydrofibre Dressing In The Local Management Of Venous Or Predominantly Venous Mixed Leg Ulcers Completed NCT01449422 Phase 4
35 Randomized Double Blind Dummy Controlled Trial Of 24 Versus 72 Hours Of Terlipressin As An Adjuvant Therapy In Acute Variceal Bleed Completed NCT00369694 Phase 4 Terlipressin;Terlipressin & then Dummy
36 Multicenter, Randomized, Double-blind, Placebo-controlled Study on the Effectiveness of Treatment With Beta-blockers to Prevent Decompensation of Cirrhosis With Portal Hypertension Completed NCT01059396 Phase 4 propranolol;carvedilol;placebo
37 Comparison of Three Different Schemes:Lactulose, L-ornithine L-aspartate, or Rifaximin, Versus Placebo, as Primary Prophylaxis of the Development of Hepatic Encephalopathy After Acute Variceal Bleeding in Cirrhotic Patients Completed NCT02158182 Phase 4 Lactulose;L-ornithine L-aspartate;Rifaximin;Placebo
38 Secondary Prophylaxis After Variceal Bleeding: Combined Treatment With Endoscopic Ligation and Nadolol Against Nadolol Associated With Mononitrate of Isosorbide or Prazosin According to Hemodynamic Response. Completed NCT00450164 Phase 4 Nadolol;Isosorbide mononitrate;Prazosin
39 The Dissemination of Consensus Recommendations on the Management of Canadian Patients With Non Variceal Upper Gastrointestinal Bleeding: A National Cluster Randomized Trial of a Multifaceted Tailored Implementation Strategy Completed NCT00840008 Phase 4
40 A Randomized Controlled Study on the Effects of PPIs on Gastroesophageal Variceal Bleeding in Liver Cirrhosis (PPIs: Proton Pump Inhibitors) Completed NCT03175731 Phase 4 Proton Pump Inhibitors;Placebo
41 Randomised Controlled Trial of Foam Sclerotherapy Versus Ambulatory Phlebectomy for the Treatment of Varicose Vein Tributaries Recruiting NCT03416413 Phase 4 Foam sclerotherapy
42 Impact of Nonselective Beta-blocker on Acute Kidney Injury in Cirrhotic Patients With Esophageal Varices Recruiting NCT04074473 Phase 4 propranolol
43 Endoscopic Treatment Versus Propranolol for Primary Prevention of Patients With Hepatocellular Carcinoma and Concomitant Esophageal Varices Recruiting NCT01970748 Phase 4 Propranolol
44 Comparison of 24-hours Versus 72-hours of Octreotide Infusion Along With Endoscopic Therapy in Preventing Early Rebleed From Esophageal Varices: a Multi-center, Randomized Clinical Study Recruiting NCT03624517 Phase 4 Octreotide
45 Beta-blockers or Placebo for Primary Prophylaxis of Oesophageal Varices (BOPPP Trial). A Blinded, Multi-centre, Clinical Effectiveness and Cost-effectiveness Randomised Controlled Trial Recruiting NCT03776955 Phase 4 Carvedilol
46 Antibiotic Prophylaxis in Patients Undergoing Endoscopic Injection of Cyanoacrylate for Primary and Secondary Prevention of Gastric Variceal Bleeding Recruiting NCT04140578 Phase 4 Ertapenem
47 Randomized Controlled Trial Comparing Propranolol, Endoscopic Banding Ligation, and Combined Treatment to Prevent First Variceal Hemorrhage in Patients With Liver Cirrhosis Recruiting NCT00965900 Phase 4 Propranolol
48 RCT Comparing the Efficacies of Endoscopic Variceal Ligation (EBL) and Combined Treatment of Beta-blocker and EBL for the Prevention of Esophageal Variceal Rebleeding Recruiting NCT00966121 Phase 4
49 RCT Comparing the Efficacies of Endoscopic Band Ligation (EBL) and Combined Treatment of Beta-blocker and EBL for the Prevention of Esophageal Variceal Rebleeding in Patients With Previous Endoscopic Variceal Treatment Recruiting NCT00966082 Phase 4
50 Primary Prevention of Gastric Variceal Bleeding : Endoscopic Treatment Versus Non-selective Beta-blocker Recruiting NCT01298271 Phase 4 propranolol

Search NIH Clinical Center for Varicose Veins

Inferred drug relations via UMLS 71 / NDF-RT 51 :


Sodium Morrhuate
Sodium Tetradecyl Sulfate

Cochrane evidence based reviews: varicose veins

Genetic Tests for Varicose Veins

Anatomical Context for Varicose Veins

MalaCards organs/tissues related to Varicose Veins:

40
Liver, Spleen, Heart, Skin, Kidney, Colon, Endothelial

Publications for Varicose Veins

Articles related to Varicose Veins:

(show top 50) (show all 20103)
# Title Authors PMID Year
1
Linkage to the FOXC2 region of chromosome 16 for varicose veins in otherwise healthy, unselected sibling pairs. 57 61
15744037 2005
2
A contribution to the problem of the inheritance of primary varicose veins. 61 57
4435791 1974
3
Genetics of varicose veins of the lower extremities. 57 61
5365895 1969
4
Female pelvic congestion syndrome: how can CT and MRI help in the management decision? 42 61
33252986 2021
5
Familiar congenital absence of valves in the deep leg veins. 57
4426629 1974
6
The heredity of venous insufficiency. 57
13561707 1958
7
Lancisi Sign: Giant C-V Waves in Tricuspid Regurgitation. 42
33276831 2020
8
Intramedullary hemorrhage from a thoracic dural arteriovenous fistula. 42
32938785 2020
9
Transcatheter embolization for stomal varices: A report of three patients. 61
33552329 2021
10
Primary undifferentiated pleomorphic cardiac sarcoma presenting as right heart failure. 61
33552334 2021
11
Favorable long-term results of endovenous laser ablation of great and small saphenous vein incompetence with a 1470-nm laser and radial fiber. 61
32599308 2021
12
Outcomes after truncal ablation with or without concomitant phlebectomy for isolated symptomatic varicose veins (C2 disease). 61
32502731 2021
13
Early results of an Asian prospective multicenter VenaSeal real-world postmarket evaluation to investigate the efficacy and safety of cyanoacrylate endovenous ablation for varicose veins. 61
32387378 2021
14
Systematic review of ambulatory selective variceal ablation under local anesthetic technique for the treatment of symptomatic varicose veins. 61
33137495 2021
15
The recommended goal in the United Kingdom's National Institute for Health and Care Excellence Clinical Guideline 168 for immediate referral of patients with bleeding varicose veins is not being achieved. 61
32726670 2021
16
Compression stockings attenuate the expression of proteins associated with vascular damage in human varicose veins. 61
32679199 2021
17
Coil migration after EUS-guided coil embolization of gastric varices. 61
32941877 2021
18
Baveno VI criteria and spleen stiffness measurement rule out high-risk varices in virally suppressed HBV-related cirrhosis. 61
33039403 2021
19
Presentation patterns in women with pelvic venous disorders differ based on age of presentation. 61
32869695 2021
20
Clinical outcome of short-term compression after sclerotherapy for telangiectatic varicose veins. 61
32502730 2021
21
Direct oral anticoagulants and advanced liver disease: A systematic review and meta-analysis. 61
32895926 2021
22
Paroxysmal Nocturnal Hemoglobinuria: Case Report of a Rare Cause of Thrombosis in the Pediatric Age. 61
31842179 2021
23
Prediction, identification and progression of histopathological liver disease activity in children with intestinal failure. 61
33002568 2021
24
Stepwise partial splenic embolization for portal hypertension based on a new concept: Splanchnic caput Medusae. 61
33408799 2021
25
Intense remodeling of extracellular matrix within the varicose vein: the role of gelatinases and vascular endothelial growth factor. 61
32594304 2021
26
Endovenous radiofrequency for chronic superficial venous insufficiency: Clinical outcomes and impact in quality of life. 61
33546819 2021
27
Quality Assessment of Bilberry Fruits (Vaccinium myrtillus) and Bilberry-Containing Dietary Supplements. 61
33587635 2021
28
Hemodynamic and Radiological Classification of Ovarian Veins System Insufficiency. 61
33567554 2021
29
Randomized Controlled Trial of Compression After Endovenous Thermal Ablation of Varicose Veins (COMETA Trial). 61
31850976 2021
30
Serum ammonia as a non-invasive marker for early prediction of esophageal varices. 61
32243345 2021
31
Screening varices in patients with HBV-related cirrhosis on antiviral therapy: Platelet alone or together with LSM. 61
33277803 2021
32
Bleeding Outcomes Following Transesophageal Echocardiography in Patients With Cirrhosis and Esophageal Varices. 61
33553975 2021
33
Correction to: Cap-Assisted Endoscopic Sclerotherapy vs Ligation in the Long-Term Management of Medium Esophageal Varices: A Randomized Trial. 61
33587490 2021
34
An unusual case of obstructed total anomalous pulmonary venous return with gastric varices. 61
33103642 2021
35
Endoscopic ultrasound-guided coil deployment with sclerotherapy for gastric varices. 61
33040299 2021
36
Esophageal adenocarcinoma on esophageal varices - endoscopic resection after transjugular intrahepatic portosystemic shunt. 61
33592651 2021
37
Bleeding from jejunal varices formed at the Roux-en-Y jejunum site caused by the compression of the left renal vein after living donor liver transplantation with renoportal anastomosis. 61
33547974 2021
38
Two-dimensional shear wave elastography for screening varices in Asian patients with primary biliary cholangitis. 61
33513034 2021
39
Balloon-occluded Retrograde Transvenous Obliteration Versus Transjugular Intrahepatic Portosystemic Shunt for Gastric Varices: A Meta-Analysis. 61
31876839 2021
40
Combined Transjugular Intrahepatic Portosystemic Shunt Plus Variceal Obliteration versus Transjugular Intrahepatic Portosystemic Shunt Alone for the Management of Gastric Varices: Comparative Single-Center Clinical Outcomes. 61
33485506 2021
41
Development of three different decision support tools to support shared decision-making in vascular surgery. 61
33277102 2021
42
Decompensation in Direct-Acting Antiviral Cured Hepatitis C Virus Compensated Patients With Clinically Significant Portal Hypertension: Too Rare to Warrant Universal Β-Blocker Therapy. 61
33606382 2021
43
Accuracy of liver and spleen stiffness on magnetic resonance elastography for detecting portal hypertension: a systematic review and meta-analysis. 61
32282542 2021
44
Variceal recurrence 4 years post endoscopic band ligation in hepatitis C patients who achieved sustained virological response with oral direct-acting antiviral therapy. 61
33098209 2021
45
Minimally invasive accessory splenectomy for recurrent gastric variceal bleeding due to left-sided portal hypertension: report of the first case. 61
33604020 2021
46
Nonsurgical Secondary Prophylaxis of Esophageal Variceal Bleeding in Cirrhotic Patients: A Systematic Review and Network Meta-analysis. 61
33122601 2021
47
Capsule endoscopy - Recent developments and future directions. 61
33111600 2021
48
Can routine blood tests be modelled to detect advanced liver disease in the community: model derivation and validation using UK primary and secondary care data. 61
33574154 2021
49
[A Case of Laparoscopic Hartmann's Procedure for Rectal Cancer with Inferior Mesenteric Vein-Left Ovarian Vein Shunt]. 61
33597382 2021
50
Pretransplantation and Post-Transplantation Liver Disease Assessment in Adolescents Undergoing Isolated Heart Transplantation for Fontan Failure. 61
32976893 2021

Variations for Varicose Veins

ClinVar genetic disease variations for Varicose Veins:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 ELN NM_000501.4(ELN):c.898A>T (p.Thr300Ser) SNV Uncertain significance 523433 rs766735416 7:73466262-73466262 7:74051932-74051932

Expression for Varicose Veins

Search GEO for disease gene expression data for Varicose Veins.

Pathways for Varicose Veins

Pathways related to Varicose Veins according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 VWF VEGFA TNF TIMP2 TIMP1 MMP9
2
Show member pathways
13.32 VWF VEGFA TNF TIMP1 MMP9 MMP3
3 12.84 VEGFA MMP9 MMP2 MMP1 IL6 HIF1A
4
Show member pathways
12.73 TIMP2 TIMP1 MMP9 MMP3 MMP2 MMP1
5
Show member pathways
12.58 TNF TIMP1 MMP2 IL6 F2
6
Show member pathways
12.34 TNF MMP9 MMP3 MMP1 IL6
7
Show member pathways
12.31 TNF MTHFR IL6 F2
8 12.3 VEGFA TNF MMP9 MMP2 HIF1A
9
Show member pathways
12.29 VEGFA TIMP1 MMP3 MMP1 HIF1A
10 12.17 VEGFA TNF IL6 HIF1A
11 12.13 VEGFA TNF MMP9 MMP2 MMP1 IL6
12 12.09 VEGFA TNF MMP9 MMP2
13 12.06 TNF IL6 HIF1A FOXC2
14 11.98 TNF MMP9 MMP3 IL6
15 11.96 VEGFA TIMP1 IL6 HIF1A
16 11.92 VEGFA TNF MMP2 IL6
17 11.86 VEGFA TNF MMP3 MMP1 IL6
18
Show member pathways
11.8 TNF TIMP2 TIMP1 MMP9 MMP3 MMP2
19 11.75 VEGFA MMP9 MMP2 MMP1
20 11.66 MMP9 MMP2 HIF1A
21 11.65 MMP9 MMP2 IL6
22 11.65 VWF TIMP2 TIMP1 MMP9 MMP3 MMP2
23 11.64 TNF TIMP1 MMP9 MMP2 IL6 ELN
24 11.58 TIMP2 TIMP1 MMP9 MMP3 MMP2 MMP1
25 11.57 VEGFA MMP1 IL6 HIF1A
26 11.55 TNF MMP2 IL6
27 11.53 TNF MMP9 MMP2 IL6
28 11.52 TNF TIMP1 IL6
29 11.39 TIMP2 MMP9 MMP3 MMP1 ELN
30 11.36 MMP9 MMP2 MMP1 IL6
31 11.33 VEGFA TNF TIMP1 MMP9 MMP3 MMP2
32 11.31 TNF MTHFR IL6
33
Show member pathways
11.3 VEGFA TNF MMP9 MMP3 MMP2 MMP1
34
Show member pathways
11.29 VEGFA TIMP1 HIF1A
35 11.18 TIMP2 TIMP1 MMP9 F2
36 11.14 VEGFA TIMP2 MMP9 HIF1A
37 11.11 MMP2 MMP1 F2
38 11.05 VEGFA TIMP1 MMP1
39 10.63 VEGFA HIF1A

GO Terms for Varicose Veins

Cellular components related to Varicose Veins according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10 VWF VEGFA TNF TIMP2 TIMP1 SERPINC1
2 extracellular region GO:0005576 9.83 VWF VEGFA TNF TIMP2 TIMP1 SHBG
3 collagen-containing extracellular matrix GO:0062023 9.7 VWF TIMP2 SERPINC1 MMP9 MMP2 F2
4 platelet alpha granule lumen GO:0031093 9.5 VWF VEGFA TIMP1
5 extracellular matrix GO:0031012 9.28 VWF VEGFA TIMP2 TIMP1 MMP9 MMP3

Biological processes related to Varicose Veins according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.91 VEGFA TNF MMP9 F2
2 leukocyte migration GO:0050900 9.91 TNF MMP9 MMP1 F2
3 response to hypoxia GO:0001666 9.87 VEGFA MTHFR MMP2 HIF1A
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.81 VEGFA TNF IL6
5 positive regulation of endothelial cell proliferation GO:0001938 9.81 VEGFA HIF1A AGGF1
6 cellular protein metabolic process GO:0044267 9.8 TIMP1 SERPINC1 MMP2 MMP1 IL6 F2
7 extracellular matrix organization GO:0030198 9.8 VWF TNF MMP9 MMP3 MMP2 MMP1
8 positive regulation of smooth muscle cell proliferation GO:0048661 9.77 TNF MMP2 IL6
9 response to hormone GO:0009725 9.77 TIMP2 TIMP1 FOXC2
10 positive regulation of protein complex assembly GO:0031334 9.76 VEGFA TNF MMP3 MMP1
11 hemostasis GO:0007599 9.75 VWF SERPINC1 F2
12 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.73 TNF MMP9 MMP2
13 outflow tract morphogenesis GO:0003151 9.72 VEGFA HIF1A ELN
14 collagen catabolic process GO:0030574 9.71 MMP9 MMP3 MMP2 MMP1
15 lactation GO:0007595 9.7 VEGFA SERPINC1 HIF1A
16 positive regulation of chemokine production GO:0032722 9.69 TNF IL6 HIF1A
17 positive regulation of JAK-STAT cascade GO:0046427 9.67 TNF IL6 F2
18 response to amyloid-beta GO:1904645 9.65 MMP9 MMP3 MMP2
19 negative regulation of lipid storage GO:0010888 9.63 TNF IL6
20 extracellular matrix disassembly GO:0022617 9.63 TIMP2 TIMP1 MMP9 MMP3 MMP2 MMP1
21 negative regulation of metallopeptidase activity GO:1905049 9.62 TIMP2 TIMP1
22 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.62 TIMP2 TIMP1
23 regulation of neuroinflammatory response GO:0150077 9.61 MMP9 MMP3 IL6
24 cytokine-mediated signaling pathway GO:0019221 9.61 VEGFA TNF TIMP1 MMP9 MMP3 MMP2
25 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.58 VEGFA HIF1A
26 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.54 TIMP1 HIF1A
27 vascular endothelial growth factor production GO:0010573 9.54 TNF IL6 HIF1A
28 cellular response to UV-A GO:0071492 9.02 TIMP1 MMP9 MMP3 MMP2 MMP1

Molecular functions related to Varicose Veins according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.91 TIMP2 TIMP1 MMP9 MMP3 MMP2 MMP1
2 cytokine activity GO:0005125 9.71 VEGFA TNF TIMP1 IL6
3 metallopeptidase activity GO:0008237 9.67 MMP9 MMP3 MMP2 MMP1
4 growth factor activity GO:0008083 9.62 VEGFA TIMP1 IL6 F2
5 metalloendopeptidase activity GO:0004222 9.56 MMP9 MMP3 MMP2 MMP1
6 endopeptidase activity GO:0004175 9.46 MMP9 MMP3 MMP2 MMP1
7 serine-type endopeptidase activity GO:0004252 9.35 MMP9 MMP3 MMP2 MMP1 F2
8 protease binding GO:0002020 9.02 VWF TNF TIMP2 TIMP1 SERPINC1

Sources for Varicose Veins

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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