MCID: VRL002
MIFTS: 24

Variola Minor

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Variola Minor

MalaCards integrated aliases for Variola Minor:

Name: Variola Minor 12 15 70
Cottonpox 12
Alastrim 12
Whitepox 12
Milkpox 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9153
ICD9CM 34 050.1
MeSH 44 D012899
NCIt 50 C34365
SNOMED-CT 67 72294005
UMLS 70 C0001906

Summaries for Variola Minor

Disease Ontology : 12 A smallpox that results in milder infection, located in skin, has material basis in Variola virus. The infection results in formation of lesions.

MalaCards based summary : Variola Minor, also known as cottonpox, is related to monkeypox and smallpox. An important gene associated with Variola Minor is PPA2 (Inorganic Pyrophosphatase 2). Affiliated tissues include skin, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 73 Smallpox was an infectious disease caused by one of two virus variants, Variola major and Variola minor.... more...

Related Diseases for Variola Minor

Diseases related to Variola Minor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 monkeypox 29.9 CYB5R3 CD55 CD46
2 smallpox 11.3
3 variola major 11.2
4 branchiootic syndrome 1 10.1
5 exanthem 10.1
6 vaccinia 10.1
7 chickenpox 10.0
8 cowpox 10.0
9 tetanus 9.9
10 diphtheria 9.9
11 typhoid fever 9.9
12 purpura 9.9
13 congenital hemolytic anemia 9.9 CYB5R3 CD46
14 complement component 3 deficiency 9.9 CD55 CD46
15 complement component 5 deficiency 9.8 CD55 CD46
16 complement deficiency 9.8 CD55 CD46
17 autosomal recessive disease 9.7 PRODH PPA2 CD55
18 hemolytic-uremic syndrome 9.6 CD55 CD46
19 hemolytic uremic syndrome, atypical 1 9.6 RBMS2 CD55 CD46

Graphical network of the top 20 diseases related to Variola Minor:



Diseases related to Variola Minor

Symptoms & Phenotypes for Variola Minor

GenomeRNAi Phenotypes related to Variola Minor according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-105 9.47 CYB5R3
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-136 9.47 PRODH
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.47 PRODH
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-192 9.47 PRODH
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-195 9.47 CYB5R3
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-198 9.47 PRODH
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.47 PRODH
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-4 9.47 PRODH
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-43 9.47 CYB5R3
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-5 9.47 PRODH
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-50 9.47 CYB5R3
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.47 PRODH
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-85 9.47 CYB5R3
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.47 PRODH

Drugs & Therapeutics for Variola Minor

Search Clinical Trials , NIH Clinical Center for Variola Minor

Genetic Tests for Variola Minor

Anatomical Context for Variola Minor

The Foundational Model of Anatomy Ontology organs/tissues related to Variola Minor:

19
Skin

Publications for Variola Minor

Articles related to Variola Minor:

(show top 50) (show all 101)
# Title Authors PMID Year
1
Bayesian reconstruction of the evolutionary history and cross-species transition of variola virus and orthopoxviruses. 61
29446492 2018
2
Emergence of Monkeypox as the Most Important Orthopoxvirus Infection in Humans. 61
30234087 2018
3
Characterization of Two Historic Smallpox Specimens from a Czech Museum. 61
28749451 2017
4
Variola minor in coalfield areas of England and Wales, 1921-34: Geographical determinants of a national smallpox epidemic that spread out of effective control. 61
28351006 2017
5
EPIPOX: Immunoinformatic Characterization of the Shared T-Cell Epitome between Variola Virus and Related Pathogenic Orthopoxviruses. 61
26605344 2015
6
Differentiation of Variola major and Variola minor variants by MGB-Eclipse probe melt curves and genotyping analysis. 61
19345728 2009
7
Public health and bioterrorism: renewed threat of anthrax and smallpox. 61
17485954 2007
8
Optimal vaccination schemes for epidemics among a population of households, with application to variola minor in Brazil. 61
17089950 2006
9
Evolutionary history of orthopoxvirus proteins similar to human complement regulators. 61
16023794 2005
10
Variola and camelpox virus-specific sequences are part of a single large open reading frame identified in two German cowpox virus strains. 61
15681053 2005
11
A new explanatory model of an SIR disease epidemic: a knowledge-based, probabilistic approach to epidemic analysis. 61
15764191 2005
12
Virulence of variola viruses for suckling mice. 61
12886813 2003
13
Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections. 61
12615299 2003
14
[Smallpox, bioterrorism agent]. 61
12497725 2002
15
Amplification of 'variola virus-specific' sequences in German cowpox virus isolates. 61
11911586 2002
16
Alastrim smallpox variola minor virus genome DNA sequences. 61
10639322 2000
17
A variant of variola virus, characterized by changes in polypeptide and endonuclease profiles. 61
10355794 1999
18
Smallpox: gone but not forgotten. 61
9795781 1998
19
The genomic sequence analysis of the left and right species-specific terminal region of a cowpox virus strain reveals unique sequences and a cluster of intact ORFs for immunomodulatory and host range proteins. 61
9568042 1998
20
Terminal region sequence variations in variola virus DNA. 61
8661439 1996
21
Comparative studies of gamma-interferon receptor-like proteins of variola major and variola minor viruses. 61
8612768 1996
22
Topography of variola smallpox virus inverted terminal repeats. 61
7645234 1995
23
PCR strategy for identification and differentiation of small pox and other orthopoxviruses. 61
7559950 1995
24
Nucleotide sequence comparison of homologous genomic regions from variola, monkeypox, and vaccinia viruses. 61
2176671 1990
25
Interdisciplinary approaches in epidemic studies--II: Four geographic models of the flow of contagious disease. 61
3823998 1987
26
The group selection of variola minor in the Americas: an anthroponootic analogue for the myxomatosis epizootic in Australia. 61
2423858 1986
27
The virology of variola minor. Correlation of laboratory tests with the geographic distribution and human virulence of variola isolates. 61
3004200 1986
28
Can variola-like viruses be derived from monkeypox virus? An investigation based on DNA mapping. 61
3002651 1985
29
An objective reconstruction of the chain of contagion. 61
6729537 1984
30
Temporal-spatial-social parameters in the spread of contagious disease. 61
6681166 1983
31
The pathogenicity of variola virus. A comparison of the growth of standard strains of variola major and variola minor viruses in cell cultures from human embryos. 61
6296226 1982
32
Surveillance of orthopoxvirus infections, and associated research, in the period after smallpox eradication. 61
6291794 1982
33
Laboratory investigation of two "whitepox" viruses and comparison with two variola strains from southern India. 61
6291795 1982
34
Enzyme studies for the characterization of some orthopoxvirus isolates. 61
6982773 1982
35
Facial scarring after varicella. A comparison with variola major and variola minor. 61
7315828 1981
36
Multivariate analysis of the role of school-attendance status in the introduction of variola minor into the household. 61
7330690 1981
37
Sequential analysis of the influence of sex on the spread of the disease variola minor. 61
7278313 1981
38
ELISA--a simple test for detecting and differentiating antibodies to closely related orthopoxviruses. 61
6276041 1981
39
Concepts of diffusion theory and a graphic approach to the description of the epidemic flow of contagious disease. 61
7422812 1980
40
Comparison of white pock (h) mutants of monkeypox virus with parental monkeypox and with variola-like viruses isolated from animals. 61
6248794 1980
41
A study of the specificities of sequential antisera to variola and monkeypox viruses by radioimmunoassay. 61
6155223 1980
42
Virion polypeptides of poxviruses. 61
6243923 1980
43
Residual skin changes in patients who have recovered from variola minor. 61
6966543 1980
44
Population-dynamics models and a sequential test in the analysis of the influence of household setting on the spread of Variola minor. 61
7401659 1980
45
Orthopoxvirus strains defective in surface antigen induction. 61
227999 1979
46
Contour mapping of the temporal-spatial progression of a contagious disease. 61
535118 1979
47
Variola minor in Braganca Paulista County, 1956: household aggregation of the disease and the influence of household size on the attack rate. 61
762399 1979
48
An analysis of the influence of age and school-attendance status on the spread of variola minor. 61
431093 1979
49
Field and experimental studies of poxvirus infections in rodents. 61
225049 1979
50
Monkeypox virus as a source of whitepox viruses. 61
91589 1979

Variations for Variola Minor

Expression for Variola Minor

Search GEO for disease gene expression data for Variola Minor.

Pathways for Variola Minor

GO Terms for Variola Minor

Biological processes related to Variola Minor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral entry into host cell GO:0046718 8.62 CD55 CD46

Molecular functions related to Variola Minor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 8.96 CD55 CD46
2 FAD binding GO:0071949 8.62 PRODH CYB5R3

Sources for Variola Minor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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