Vas Deferens, Congenital Bilateral Aplasia of, X-Linked disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

MalaCards integrated aliases for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked:

Name: Vas Deferens, Congenital Bilateral Aplasia of, X-Linked ⁵⁷ ²⁹ ⁶

Cbavdx ⁵⁷ ¹² ⁷²

Congenital Bilateral Absence of Vas Deferens, X-Linked ⁵⁷ ²⁹

X-Linked Congenital Bilateral Absence of Vas Deferens ¹² ¹⁵

Congenital Bilateral Aplasia of the Vas Deferens, X-Linked ⁷²

Male Urogenital Diseases ⁷⁰

Characteristics:

OMIM®:

⁵⁷ (Updated 05-Apr-2021)

Inheritance:
x-linked

HPO:

³¹

vas deferens, congenital bilateral aplasia of, x-linked:
Inheritance x-linked inheritance

Classifications:

MalaCards categories:
Global: Genetic diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0111863

OMIM® ⁵⁷ 300985

OMIM Phenotypic Series ⁵⁷ PS277180

MeSH ⁴⁴ D052801

MedGen ⁴¹ C4310815 CN238523

SNOMED-CT via HPO ⁶⁸ 263934009 300506000 425558002 more

UMLS ⁷⁰ C1720894

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Summaries for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

OMIM® : ⁵⁷ Congenital bilateral absence of the vas deferens (CBAVD) is found in more than 25% of men with obstructive azoospermia, involving a complete or partial defect of the Wolffian duct derivatives. In 80% of men with CBAVD (see 277180), mutations are identified in the CFTR gene (602421). The forms caused by mutations in the CFTR and ADGRG2 genes are clinically indistinguishable (summary by Patat et al., 2016). (300985) (Updated 05-Apr-2021)

MalaCards based summary : Vas Deferens, Congenital Bilateral Aplasia of, X-Linked, also known as cbavdx, is related to vas deferens, congenital bilateral aplasia of and azoospermia, and has symptoms including pathological conditions, signs and symptoms An important gene associated with Vas Deferens, Congenital Bilateral Aplasia of, X-Linked is ADGRG2 (Adhesion G Protein-Coupled Receptor G2). The drugs Oxybutynin and Parasympatholytics have been mentioned in the context of this disorder. Affiliated tissues include liver, and related phenotypes are azoospermia and absent vas deferens

Disease Ontology : ¹² A congenital bilateral absence of vas deferens that has material basis in mutation in ADGRG2 on chromosome Xp22.13.

UniProtKB/Swiss-Prot : ⁷² Congenital bilateral aplasia of the vas deferens, X-linked: A disease characterized by bilateral absence of vas deferens, obstructive azoospermia, and infertility.

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Related Diseases for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

Diseases related to Vas Deferens, Congenital Bilateral Aplasia of, X-Linked via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	vas deferens, congenital bilateral aplasia of	30.0	CFTR ADGRG2
2	azoospermia	30.0	CFTR ADGRG2
3	infertility	29.7	CFTR ADGRG2
4	renal hypodysplasia/aplasia 1	10.4
5	male infertility	9.6	CFTR ADGRG2

Graphical network of the top 20 diseases related to Vas Deferens, Congenital Bilateral Aplasia of, X-Linked:

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Symptoms & Phenotypes for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

Human phenotypes related to Vas Deferens, Congenital Bilateral Aplasia of, X-Linked:

³¹

#	Description	HPO Frequency	HPO Source Accession
1	azoospermia ³¹		HP:0000027
2	absent vas deferens ³¹		HP:0012873

Symptoms via clinical synopsis from OMIM®:

⁵⁷ (Updated 05-Apr-2021)

Genitourinary Internal Genitalia Male:
azoospermia
absent vas deferens
low semen volume
reduced testicular volume (in some patients)
acid ph of semen (in some patients)
more

Clinical features from OMIM®:

300985 (Updated 05-Apr-2021)

UMLS symptoms related to Vas Deferens, Congenital Bilateral Aplasia of, X-Linked:

pathological conditions, signs and symptoms

Sources

Drugs & Therapeutics for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

Drugs for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Oxybutynin

Approved, Investigational

Phase 2

5633-20-5

4634

Synonyms:

1508-65-2 (hydrochloride)

4-(Diethylamino)-2-butynyl alpha-phenylcyclohexaneglycolate ester

4-(Diethylamino)-2-butynyl alpha-phenylcyclohexaneglycolic acid ester

4-(Diethylamino)-2-butynyl a-phenylcyclohexaneglycolate ester

4-(Diethylamino)-2-butynyl a-phenylcyclohexaneglycolic acid ester

4-(Diethylamino)-2-butynyl α-phenylcyclohexaneglycolate ester

4-(Diethylamino)-2-butynyl α-phenylcyclohexaneglycolic acid ester

4-(diethylamino)-2-butynyl-alpha-cyclohexyl-alpha-hydroxybenzeneacetate

4-(Diethylamino)-2-butynyl-alpha-cyclohexyl-alpha-hydroxybenzeneacetate

4-(diethylamino)-2-butynyl-alpha-phenylcyclohexaneglycolate

4-(Diethylamino)-2-butynyl-alpha-phenylcyclohexaneglycolate

4-(diethylamino)but-2-yn-1-yl cyclohexyl(hydroxy)phenylacetate

4-(diethylamino)but-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylacetate

4-Diethylamino-2-butinyl a-cyclohexylmandelat

4-Diethylamino-2-butinyl alpha-cyclohexylmandelat

4-Diethylamino-2-butinyl α-cyclohexylmandelat

4-Diethylamino-2-butynyl alpha-phenylcyclohexaneglycolate

4-Diethylamino-2-butynyl alpha-phenylcyclohexaneglycolic acid

4-Diethylamino-2-butynyl a-phenylcyclohexaneglycolate

4-Diethylamino-2-butynyl a-phenylcyclohexaneglycolic acid

4-Diethylamino-2-butynyl α-phenylcyclohexaneglycolate

4-Diethylamino-2-butynyl α-phenylcyclohexaneglycolic acid

5633-20-5

AC1L1ILV

AC-2153

Anturol

Apo-oxybutynin

Benzeneacetate, a-cyclohexyl-a-hydroxy-, 4-(diethylamino)-2-butynyl ester

Benzeneacetate, alpha-cyclohexyl-alpha-hydroxy-, 4-(diethylamino)-2-butynyl ester

Benzeneacetate, α-cyclohexyl-α-hydroxy-, 4-(diethylamino)-2-butynyl ester

Benzeneacetic acid, a-cyclohexyl-a-hydroxy-, 4-(diethylamino)-2-butynyl ester

Benzeneacetic acid, alpha-cyclohexyl-alpha-hydroxy-, 4-(diethylamino)-2-butynyl ester

Benzeneacetic acid, α-cyclohexyl-α-hydroxy-, 4-(diethylamino)-2-butynyl ester

BPBio1_000214

BRD-A65013509-003-03-8

BSPBio_000194

C07360

CCRIS 1923

CHEBI:7856

CHEMBL1231

CID4634

Contimin

Cyclohexaneglycolate, alpha-phenyl-, 4-(diethylamino)-2-butynyl ester

Cyclohexaneglycolate, a-phenyl-, 4-(diethylamino)-2-butynyl ester

Cyclohexaneglycolate, α-phenyl-, 4-(diethylamino)-2-butynyl ester

Cyclohexaneglycolic acid, .alpha.-phenyl-, 4-(diethylamino)-2-butynyl ester

Cyclohexaneglycolic acid, alpha-phenyl-, 4-(diethylamino)-2-butynyl ester

Cyclohexaneglycolic acid, a-phenyl-, 4-(diethylamino)-2-butynyl ester

Cyclohexaneglycolic acid, α-phenyl-, 4-(diethylamino)-2-butynyl ester

Cystonorm

Cystrin

D00465

DB01062

Ditropan

Ditropan, Lyrinel XL, Oxytrol, Oxybutynin

Dresplan

Dridase

Driptane

FT-0082890

Gelnique

Gen-oxybutynin

HSDB 3270

I06-2117

Kentera

L000923

Lopac0_000923

LS-28714

MolPort-003-849-741

NCGC00015767-06

NCGC00089795-02

Novo-oxybutynin

Nu-oxybutyn

Oxibutinina

Oxibutinina [INN-Spanish]

Oxibutyninum

Oxyb abz

Oxybugamma

Oxybutin holsten

Oxybutinin

Oxybuton

oxybutynin

Oxybutynin

Oxybutynin (USAN/INN)

Oxybutynin [USAN:INN:BAN]

Oxybutynin al

Oxybutynin azu

Oxybutynin base

Oxybutynin Base

Oxybutynin chloride

Oxybutynin heumann

Oxybutynin hexal

Oxybutynin hydrochloride

Oxybutynin stada

oxybutynin topical gel

Oxybutynin topical gel

Oxybutynin von CT

Oxybutynine

Oxybutynine [INN-French]

Oxybutynin-puren

Oxybutynin-ratiopharm

Oxybutyninum

Oxybutyninum [INN-Latin]

Oxymedin

Oxytrol

Oxytrol (TN)

PMS-Oxybutynin

Pollakisu

Prestwick0_000287

Prestwick1_000287

Prestwick2_000287

Prestwick3_000287

Renamel

Ryol

S1754_Selleck

Spasmex oxybutynin

Spasyt

SPBio_002413

Tavor

transdermal patch

Transdermal patch

UNII-K9P6MC7092

Zatur

2

Parasympatholytics

Phase 2

3

Neurotransmitter Agents

Phase 2

4

Muscarinic Antagonists

Phase 2

5

Cholinergic Agents

Phase 2

6

Liver Extracts

Phase 2

7

Cholinergic Antagonists

Phase 2

8

Ceftriaxone

Approved

Phase 1

73384-59-5

5479530 5361919

Synonyms:

(6R,7R)-7-({(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(methyloxy)imino]acetyl}amino)-3-{[(6-hydroxy-2-methyl-5-oxo-2,5-dihydro-1,2,4-triazin-3-yl)thio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-7-(2-(2-Amino-4-thiazolyl)glyoxylamido)-8-oxo-3-(((1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-triazin-3-yl)thio)methyl)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7(sup 2)-(Z)-(O-methyloxime), sesquaterhydrate

(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-5,6-dioxo-1H-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulphanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulphanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

104376-79-6

104376-79-6 (di-hydrochloride salt)

73384-59-5

74578-69-1 (di-hydrochloride salt, hemiheptahydrate)

7beta-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-3,4-didehydrocepham-4-carboxylic acid

AC-1592

AC1NUIFE

Anhydrous ceftriaxone sodium

Benaxona

Biotrakson

Boehringer mannheim brand OF ceftriaxone sodium

C06683

C18H18N8O7S3

Cefatriaxone

Cefaxona

Ceftrex

Ceftriaxon

Ceftriaxon curamed

Ceftriaxon hexal

Ceftriaxona

Ceftriaxona [INN-Spanish]

Ceftriaxona andreu

Ceftriaxona LDP torlan

ceftriaxone

Ceftriaxone

Ceftriaxone (INN)

Ceftriaxone (TN)

Ceftriaxone [USAN:JAN]

Ceftriaxone intravenous

Ceftriaxone irex

Ceftriaxone sodium

CEFTRIAXONE SODIUM

Ceftriaxone sodium, anhydrous

Ceftriaxone, disodium salt

Ceftriaxone, Disodium Salt

Ceftriaxone, disodium salt, hemiheptahydrate

Ceftriaxone, Disodium Salt, Hemiheptahydrate

Ceftriaxonum

Ceftriaxonum [INN-Latin]

Ceftriazone

CHEBI:29007

CHEMBL161

CID5479530

Columbia brand OF ceftriaxone

CTRX

Curamed brand OF ceftriaxone sodium

D07659

DB01212

DRG-0071

EINECS 277-405-6

Fustery brand OF ceftriaxone sodium

Galen brand OF ceftriaxone sodium

Hexal brand OF ceftriaxone sodium

Hoffman la roche brand OF ceftriaxone sodium

Hoffman-la roche brand OF ceftriaxone sodium

Inibsa brand OF ceftriaxone sodium

Irex brand OF ceftriaxone

Lendacin

Longacef

Longaceph

LS-150031

MolPort-005-933-495

Pisa brand OF ceftriaxone sodium

Ro 139904

Ro13-9904

Ro-13-9904

Rocefalin

Rocefin

Rocephin

Rocephine

Roche brand OF ceftriaxone sodium

Sodium, ceftriaxone

Syntex brand OF ceftriaxone sodium

Tacex

Terbac

UNII-75J73V1629

9

Lidocaine

Approved, Vet_approved

Phase 1

137-58-6

3676

Synonyms:

.alpha.-(Diethylamino)-2,6-acetoxylidide

.alpha.-Diethylamino-2,6-dimethylacetanilide

.alpha.-Diethylaminoaceto-2,6-xylidide

.omega.-Diethylamino-2,6-dimethylacetanilide

137-58-6

2-(Diethylamino)-2',6'-acetoxylidide

2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide

2-2ETN-2MePhAcN

2-Diethylamino-N-(2,6-dimethylphenyl)acetamide

2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide

4-12-00-02538 (Beilstein Handbook Reference)

6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))

6108-05-0 (mono-hydrochloride, mono-hydrate)

73-78-9 (mono-hydrochloride)

AB00053581

AC-10282

AC1L1GGQ

AC1Q2Z7J

a-Diethylamino-2,6-dimethylacetanilide

After Burn Double Strength Gel

After Burn Double Strength Spray

After Burn Gel

After Burn Spray

AKOS001026768

alfa-Dietilamino-2,6-dimetilacetanilide

alfa-Dietilamino-2,6-dimetilacetanilide [Italian]

Alphacaine

alpha-diethylamino-2,6-dimethylacetanilide

alpha-Diethylamino-2,6-dimethylacetanilide

Anestacon

Anestacon Jelly

ARONIS23855

Astrazeneca brand OF lidocaine

BIDD:GT0342

Bio-0767

Bio1_000379

Bio1_000868

Bio1_001357

Bio2_000079

Bio2_000559

BPBio1_000197

BRD-K52662033-001-02-6

BRD-K52662033-003-05-5

BRN 2215784

BSPBio_000179

BSPBio_001359

BSPBio_003004

C07073

C14H22N2O

Cappicaine

CAS-73-78-9

CDS1_000283

CHEBI:6456

CHEMBL79

CID3676

Cito optadren

CPD000058189

Cuivasil

D00358

Dalcaine

DB00281

Dentipatch

Dentipatch (TN)

DermaFlex

Diethylaminoaceto-2,6-xylidide

Dilocaine

DivK1c_000174

DivK1c_001323

Duncaine

EINECS 205-302-8

ELA-Max

EMBOLEX

Emla Cream

Esracaine

FT-0082378

Gravocain

HMS1791D21

HMS1989D21

HMS2051C21

HMS2089E15

HMS548M19

HSDB 3350

I01-2704

IDI1_000174

IDI1_033829

Isicaina

Isicaine

Jenapharm brand OF lidocanine hydrochloride

Jetocaine

KBio1_000174

KBio2_000079

KBio2_001598

KBio2_002647

KBio2_004166

KBio2_005215

KBio2_006734

KBio3_000157

KBio3_000158

KBio3_002224

KBioGR_000079

KBioGR_000599

KBioSS_000079

KBioSS_001598

L0156

L1026_SIGMA

L7757_SIGMA

Lanabiotic

L-Caine

Leostesin

Lida-Mantle

Lidocaina

Lidocaína

Lidocaina [INN-Spanish]

lidocaine

Lidocaine

LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)

Lidocaine (JP15/USP/INN)

Lidocaine (VAN)

Lidocaine [USAN:INN:JAN]

Lidocaine carbonate

Lidocaine Carbonate

Lidocaine carbonate (2:1)

Lidocaine hydrocarbonate

Lidocaine Hydrocarbonate

Lidocaine hydrochloride

Lidocaine monoacetate

Lidocaine monohydrochloride

Lidocaine Monohydrochloride

Lidocaine monohydrochloride, monohydrate

Lidocaine sulfate (1:1)

Lidocainum

Lidocainum [INN-Latin]

Lidocaton

Lidoderm

Lidoject-1

Lidoject-2

LIDOPEN

Lignocaine

Lignocainum

Lingocaine

Lopac0_000669

Lopac-L-5647

LQZ

LS-805

Maricaine

Maybridge1_002571

MLS000069724

MLS000758263

MLS001074177

MolPort-001-783-478

N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide

N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide

NCGC00015611-01

NCGC00015611-02

NCGC00015611-03

NCGC00015611-04

NCGC00015611-14

NCGC00022176-05

NCGC00022176-06

NCGC00022176-07

NCGC00022176-08

NCGC00022176-09

nchembio.65-comp16

NINDS_000174

Norwood Sunburn Spray

Novocol brand OF lidocaine hydrochloride

NSC 40030

NSC40030

Octocaine

Octocaine-100

Octocaine-50

Prestwick0_000050

Prestwick1_000050

Prestwick2_000050

Prestwick3_000050

Remicaine

Rocephin Kit

Rucaina

S1357_Selleck

SAM001247018

SMR000058189

Solarcaine aloe extra burn relief cream

Solcain

SPBio_001525

SPBio_002100

Spectrum_001118

Spectrum2_001343

Spectrum3_001392

Spectrum4_000070

Spectrum5_001549

STK552033

Strathmann brand OF lidocaine hydrochloride

UNII-98PI200987

WLN: 2N2 & 1VMR B1 F1

Xilina

Xilocaina

Xilocaina [Italian]

Xllina

Xycaine

Xylestesin

Xylesthesin

Xylocain

Xylocaine

Xylocaine (TN)

Xylocaine 5% Spinal

Xylocaine CO2

Xylocaine Dental Ointment

Xylocaine Endotracheal

Xylocaine Test Dose

Xylocaine Viscous

Xylocaine-Mpf

Xylocaine-Mpf with Glucose

Xylocard

Xylocitin

Xyloneural

Xyloneural (free base)

Xylotox

Zilactin-L

Zingo

α-diethylamino-2,6-dimethylacetanilide

Α-diethylamino-2,6-dimethylacetanilide

10

Antibiotics, Antitubercular

Phase 1

11

Anesthetics

Phase 1

12

Anti-Bacterial Agents

Phase 1

13

Desflurane

Approved

57041-67-5

42113

Synonyms:

(+-)-2-Difluoromethyl 1,2,2,2-tetrafluoroethyl ether

(±)-2-difluoromethyl 1,2,2,2-tetrafluoroethyl ether

1,1,1,2-tetrafluoro-2-(difluoromethoxy)ethane

1,1,1,2-Tetrafluoro-2-(difluoromethoxy)ethane

1,2,2,2-Tetrafluoroethyl difluoromethyl ether

2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane

57041-67-5

AC1L274J

AC1Q4ICY

Baxter anaesthesia brand OF desflurane

Baxter brand OF desflurane

C07519

C3H2F6O

CHEBI:4445

CHEMBL1200733

CID42113

D00546

DB01189

Desflurane

DESFLURANE

Desflurane (JAN/USP/INN)

Desflurane [USAN:INN]

Desflurano

Desflurano [INN-Spanish]

Desfluranum

Desfluranum [INN-Latin]

difluoromethyl 1,2,2,2-tetrafluoroethyl ether

Difluoromethyl 1,2,2,2-tetrafluoroethyl ether

I 653

I653

I-653

LS-65505

MolPort-001-776-387

Ohmeda brand OF desflurane

PC6781E

r-e 236ea1

Suprane

Suprane (TN)

UNII-CRS35BZ94Q

Zeneca brand OF desflurane

14

Nimodipine

Approved, Investigational

66085-59-4

4497

Synonyms:

1,4-Dihydro-2,6-dimethyl-4-(3&prime

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester

1-methylethyl 2-(methyloxy)ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

2,6-Dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 3-beta-methoxyethyl ester 5-isopropyl ester

2,6-Dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 3-b-methoxyethyl ester 5-isopropyl ester

2,6-Dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 3-β-methoxyethyl ester 5-isopropyl ester

2,6-Dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-beta-methoxyethyl ester 5-isopropyl ester

2,6-Dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-b-methoxyethyl ester 5-isopropyl ester

2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-methoxyethyl ester 5-isopropyl ester

2,6-Dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-methoxyethyl ester 5-isopropyl ester

2-methoxyethyl propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

2-Methoxyethyl-1-methylethyl ester

3-(2-methoxyethyl) 5-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

3,5-pyridinecarboxylic acid 2-methoxyethyl 1-methylethyl ester

3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl), 2-methoxyethyl 1-methylethyl ester

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 1-methylethyl ester

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,2-methoxyethyl 1-methylethyl ester

3-O-(2-methoxyethyl) 5-O-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-N,N-dimethyl-2,2-diphenyl-butanamide

66085-59-4

9736, Bay e

AB00513963

AC-11694

AC1L1IAS

AC1Q4G7S

Admon

Almirall brand OF nimodipine

Almirall Brand of Nimodipine

Alpharma brand OF nimodipine

Alpharma Brand of Nimodipine

Andromaco brand OF nimodipine

Andromaco Brand of Nimodipine

BAY e 9736

Bay-E 9736

Bay-e-9736

Bayer brand OF nimodipine

Bayer Brand of Nimodipine

Bayvit brand OF nimodipine

Bayvit Brand of Nimodipine

Bayvit, nimodipino

Bio-0178

Bio1_000118

Bio1_000607

Bio1_001096

Bio2_000117

Bio2_000597

BPBio1_000876

Brainal

BRD-A58048407-001-06-3

BRN 0459792

BSPBio_000796

BSPBio_001397

BSPBio_002412

C07267

C21H26N2O7

Calnit

Cantabria brand OF nimodipine

Cantabria Brand of Nimodipine

CBiol_001832

CHEBI:160965

CHEBI:465248

CHEMBL1428

CHEMBL40792

CID4497

CPD000058300

D00438

D009553

DB00393

DivK1c_006812

DRG-0139

e 9736, Bay

EG-1961

EINECS 266-127-0

Elan brand OF nimodipine

Elan Brand of Nimodipine

Esteve brand OF nimodipine

Esteve Brand of Nimodipine

EU-0100891

FT-0082761

Hexal brand OF nimodipine

Hexal Brand of Nimodipine

Hexal, nimodipin

HMS1361F19

HMS1570H18

HMS1791F19

HMS1922E04

HMS1989F19

HMS2052M05

HMS2089H13

HMS2093G11

I06-0230

IDI1_033867

isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid

isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate

Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate

Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylic acid

KBio1_001756

KBio2_000117

KBio2_002403

KBio2_002685

KBio2_004971

KBio2_005253

KBio2_007539

KBio3_000233

KBio3_000234

KBio3_001632

KBioGR_000117

KBioGR_001262

KBioSS_000117

KBioSS_002408

Kenesil

Lopac0_000891

LS-131292

MLS000069381

MLS000863294

MLS001076550

MLS002154061

MLS002172461

Modus

MolPort-001-840-190

N-149

N149_SIGMA

NCGC00015714-04

NCGC00015714-12

NCGC00024675-02

NCGC00024675-03

NCGC00024675-04

NCGC00024675-05

NCGC00024675-06

NCGC00024675-07

NCGC00024675-08

NCGC00024675-09

nchembio.476-comp9

nchembio.79-comp6

Nimodipin hexal

Nimodipin Hexal

Nimodipin isis

Nimodipin ISIS

nimodipine

Nimodipine

Nimodipine (USAN/INN)

Nimodipine [USAN:BAN:INN]

Nimodipin-isis

NimodipinISIS

Nimodipin-ISIS

Nimodipino

Nimodipino [INN-Spanish]

Nimodipino bayvit

Nimodipino Bayvit

Nimodipinum

Nimodipinum [INN-Latin]

NimoGel

Nimotop

NIMOTOP (TN)

Nimotop(TM)

Nimotop, Nimodipine

-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl-1-methylethyl Ester

Nymalize

Periplum

Periplum, Nimotop, BRN 0459792, DRG-0139

Prestwick0_000918

Prestwick1_000918

Prestwick2_000918

Prestwick3_000918

Remontal

S1747_Selleck

SAM001246890

SMR000058300

SPBio_001464

SPBio_002985

SpecPlus_000716

Spectrum_001880

SPECTRUM1503600

Spectrum2_001562

Spectrum3_000766

Spectrum4_000791

Spectrum5_001687

STK642934

UNII-57WA9QZ5WH

Vita brand OF nimodipine

Vita Brand of Nimodipine

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Prospective Randomized Clinical Trial of Early Oxybutinin Treatment for Boys With Posterior Urethral Valves	Not yet recruiting	NCT04526353	Phase 2	Oxybutynin 1 mg/ml Syrup
2	Soractelite(Tm) Transperineal Laser Ablation for Benign Prostatic Hyperplasia With Bladder Outlet Obstruction	Recruiting	NCT04760483	Phase 1
3	Comparing Gas Consumption With Conventional Low Flow Ventilation and Gas Control Systems From Two Different Anesthesia Machines: Flow-i and Aisys	Completed	NCT02774031

Search NIH Clinical Center for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

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Genetic Tests for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

Genetic tests related to Vas Deferens, Congenital Bilateral Aplasia of, X-Linked:

#	Genetic test	Affiliating Genes
1	Vas Deferens, Congenital Bilateral Aplasia of, X-Linked ²⁹	ADGRG2
2	Congenital Bilateral Absence of Vas Deferens, X-Linked ²⁹

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Anatomical Context for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

MalaCards organs/tissues related to Vas Deferens, Congenital Bilateral Aplasia of, X-Linked:

⁴⁰

Liver

Sources

Publications for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

Articles related to Vas Deferens, Congenital Bilateral Aplasia of, X-Linked:

#	Title	Authors	PMID	Year
1	Truncating Mutations in the Adhesion G Protein-Coupled Receptor G2 Gene ADGRG2 Cause an X-Linked Congenital Bilateral Absence of Vas Deferens. ⁶¹ ⁶ ⁵⁷	Patat O...Bieth E	27476656	2016

Sources

Genes for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

Genes related to Vas Deferens, Congenital Bilateral Aplasia of, X-Linked (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	ADGRG2	Adhesion G Protein-Coupled Receptor G2	Protein Coding	1016.76	Molecular basis known ⁵⁷ Pathogenic ⁶ Genetic Tests ²⁹ DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)	27476656
2	CFTR	CF Transmembrane Conductance Regulator	Protein Coding	4.35	DISEASES inferred ¹⁵

Sources

Variations for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

ClinVar genetic disease variations for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked:

⁶

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	ADGRG2	NM_001079858.3(ADGRG2):c.2002_2006delinsAGA (p.Leu668fs)	Indel	Pathogenic	253014	rs879255539	GRCh37: X:19021188-19021192 GRCh38: X:19003070-19003074
2	ADGRG2	NM_001079858.3(ADGRG2):c.1545dup (p.Glu516Ter)	Duplication	Pathogenic	253015	rs774488954	GRCh37: X:19026118-19026119 GRCh38: X:19008000-19008001
3	ADGRG2	NM_001079858.3(ADGRG2):c.2845del (p.Cys949fs)	Deletion	Pathogenic	253013	rs879255538	GRCh37: X:19013038-19013038 GRCh38: X:18994920-18994920
4	ADGRG2	NM_001079858.3(ADGRG2):c.1618G>A (p.Val540Ile)	SNV	Uncertain significance	1028509		GRCh37: X:19025424-19025424 GRCh38: X:19007306-19007306

Sources

Expression for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

Search GEO for disease gene expression data for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked.

Sources

Pathways for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

Sources

GO Terms for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

Cellular components related to Vas Deferens, Congenital Bilateral Aplasia of, X-Linked according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:0009986	8.96	CFTR ADGRG2
2	apical plasma membrane	GO:0016324	8.62	CFTR ADGRG2

Sources

Sources for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia

Vas Deferens, Congenital Bilateral Aplasia of, X-Linked (CBAVDX)

Aliases & Classifications for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

MalaCards integrated aliases for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked:

Characteristics:

OMIM®:

HPO:

Classifications:

External Ids:

Summaries for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

Related Diseases for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

Diseases related to Vas Deferens, Congenital Bilateral Aplasia of, X-Linked via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Vas Deferens, Congenital Bilateral Aplasia of, X-Linked:

Symptoms & Phenotypes for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

Human phenotypes related to Vas Deferens, Congenital Bilateral Aplasia of, X-Linked:

Symptoms via clinical synopsis from OMIM®:

Clinical features from OMIM®:

UMLS symptoms related to Vas Deferens, Congenital Bilateral Aplasia of, X-Linked:

Drugs & Therapeutics for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

Drugs for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Genetic Tests for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

Genetic tests related to Vas Deferens, Congenital Bilateral Aplasia of, X-Linked:

Anatomical Context for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

MalaCards organs/tissues related to Vas Deferens, Congenital Bilateral Aplasia of, X-Linked:

Publications for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

Articles related to Vas Deferens, Congenital Bilateral Aplasia of, X-Linked:

Genes for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

Genes related to Vas Deferens, Congenital Bilateral Aplasia of, X-Linked (1 elite genes):

Variations for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

ClinVar genetic disease variations for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked:

Expression for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

Pathways for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

GO Terms for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked

Cellular components related to Vas Deferens, Congenital Bilateral Aplasia of, X-Linked according to GeneCards Suite gene sharing:

Sources for Vas Deferens, Congenital Bilateral Aplasia of, X-Linked