MCID: VSC006
MIFTS: 49

Vascular Cancer

Categories: Blood diseases, Cancer diseases, Cardiovascular diseases, Nephrological diseases

Aliases & Classifications for Vascular Cancer

MalaCards integrated aliases for Vascular Cancer:

Name: Vascular Cancer 12 15
Malignant Vascular Neoplasm 12 74
Renal Vein Leiomyosarcoma 12 74
Blood Vessel Tumors 12 56
Vascular Neoplasms 45 74
Malignant Tumor of Pulmonary Artery 12
Pulmonary Artery Malignant Neoplasm 12
Malignant Neoplasm of Great Vessels 74
Malignant Tumor of Pulmonary Vein 12
Pulmonary Vein Malignant Neoplasm 12
Leiomyosarcoma of the Renal Vein 12
Blood Vessel Tumour Disorder 12
Malignant Great Vessel Tumor 12
Neoplasms, Vascular Tissue 74
Malignant Vascular Tumor 12
Neoplasm of Great Vessel 12
Vascular Tissue Neoplasm 12
Haemangiomatous Tumour 12
Blood Vessel Neoplasm 12
Blood Vessel Cancer 74
Blood Vessel Tumor 12
Vascular Tumors 12

Classifications:



Summaries for Vascular Cancer

Disease Ontology : 12 A cardiovascular cancer that is located in blood vessels.

MalaCards based summary : Vascular Cancer, also known as malignant vascular neoplasm, is related to glomeruloid hemangioma and kaposiform hemangioendothelioma. An important gene associated with Vascular Cancer is FLT4 (Fms Related Tyrosine Kinase 4), and among its related pathways/superpathways are TGF-Beta Pathway and CREB Pathway. The drugs Cyclophosphamide and Propranolol have been mentioned in the context of this disorder. Affiliated tissues include blood vessels, endothelial and cerebellum, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Vascular Cancer

Diseases related to Vascular Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
# Related Disease Score Top Affiliating Genes
1 glomeruloid hemangioma 31.2 CD34 ENG FLT1 VEGFA
2 kaposiform hemangioendothelioma 31.2 CD34 FLI1 FLT4 KDR PECAM1 VWF
3 juvenile nasopharyngeal angiofibroma 31.0 ENG FGF2 KIT PECAM1 VEGFA
4 breast angiosarcoma 30.9 CD34 KIT
5 angiosarcoma 30.1 FLI1 FLT1 FLT4 KDR KIT PECAM1
6 capillary hemangioma 29.9 FLT1 KDR PECAM1 VEGFA
7 epithelioid hemangioendothelioma 29.8 CAMTA1 FLT1 KDR VEGFA
8 retinal vascular disease 29.7 FLT1 KDR VEGFA
9 kaposi sarcoma 29.5 FGF2 KDR VEGFA
10 hemangioendothelioma 29.4 CAMTA1 FLI1 FLT4 KDR PECAM1
11 cavernous hemangioma 29.4 FGF2 KDR KIT PECAM1
12 renal cell carcinoma, nonpapillary 29.3 FGF2 FLT1 FLT4 KDR KIT PDGFRB
13 hemangioma 28.6 CD34 FGF2 FLT1 FLT4 KDR PECAM1
14 hemangioma-thrombocytopenia syndrome 11.4
15 angioma, tufted 11.3
16 hemangioblastoma 11.3
17 littoral cell angioma of the spleen 11.3
18 ovarian angiosarcoma 11.1
19 hemangioma, capillary infantile 10.9
20 meningioma, familial 10.9
21 skin angiosarcoma 10.9
22 brain stem angioblastoma 10.9
23 carotid body cancer 10.9
24 leiomyosarcoma 10.5
25 hemifacial spasm 10.4 FLT4 VEGFA
26 infiltrating angiolipoma 10.3 VEGFA VWF
27 bone squamous cell carcinoma 10.3 ENG KDR
28 lymphangioma 10.3 FLT4 KDR VEGFA
29 posterior uveal melanoma 10.3 THBS1 VEGFA
30 angiomatous meningioma 10.3 FGF2 KDR VEGFA
31 angiokeratoma circumscriptum 10.3 FLT1 KDR VEGFA
32 skin hemangioma 10.3 FLT1 KDR VEGFA
33 placental insufficiency 10.3 FLT1 KDR VEGFA
34 proliferative fasciitis 10.3 CAMTA1 SERPINA3
35 exudative vitreoretinopathy 1 10.3 FLT1 KDR VEGFA
36 intravascular papillary endothelial hyperplasia 10.2 SERPINA3 VEGFA
37 hydrocele 10.2 FLT4 PECAM1 VEGFA
38 microcystic meningioma 10.2 FLT1 VEGFA
39 chronic myocardial ischemia 10.2 FGF2 VEGFA
40 microvascular complications of diabetes 1 10.2 FGF2 FLT1 VEGFA
41 arteries, anomalies of 10.2 FLT1 VEGFA VWF
42 hellp syndrome 10.2 ENG FLT1 VWF
43 breast carcinoma in situ 10.2 FGF2 FLT1 FLT4 VEGFA
44 platelet aggregation, spontaneous 10.1 SERPINA3 VWF
45 microvascular complications of diabetes 5 10.1 FGF2 FLT1 KDR VEGFA
46 limb ischemia 10.1 FGF2 KDR VEGFA VWF
47 drug-induced lupus erythematosus 10.1 ENG KDR VEGFA VWF
48 macular degeneration, age-related, 1 10.1 FGF2 FLT1 KDR VEGFA
49 angiodysplasia 10.1 ENG FGF2 VEGFA VWF
50 arteriovenous malformations of the brain 10.1 ENG KDR THBS1 VEGFA

Graphical network of the top 20 diseases related to Vascular Cancer:



Diseases related to Vascular Cancer

Symptoms & Phenotypes for Vascular Cancer

MGI Mouse Phenotypes related to Vascular Cancer:

47 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.38 ANPEP ENG FGF2 FLI1 FLT1 FLT4
2 hematopoietic system MP:0005397 10.32 ANPEP CD34 ENG FGF2 FLI1 FLT1
3 cellular MP:0005384 10.3 CD34 FGF2 FLI1 FLT1 KDR KIT
4 immune system MP:0005387 10.29 ANPEP CD248 CD34 FLI1 FLT1 FLT4
5 homeostasis/metabolism MP:0005376 10.27 CD34 ENG FGF2 FLT1 FLT4 KDR
6 growth/size/body region MP:0005378 10.22 CAMTA1 ENG FLI1 FLT1 FLT4 KDR
7 mortality/aging MP:0010768 10.18 CAMTA1 ENG FGF2 FLI1 FLT1 FLT4
8 digestive/alimentary MP:0005381 10.15 ENG FLT4 KIT PDGFRB PECAM1 THBS1
9 embryo MP:0005380 10.14 ENG FLI1 FLT1 FLT4 KDR KIT
10 integument MP:0010771 10.11 ANPEP CD34 ENG FLT4 KDR KIT
11 muscle MP:0005369 10.11 ENG FGF2 FLI1 FLT1 FLT4 KDR
12 liver/biliary system MP:0005370 9.98 FLI1 FLT4 KDR KIT PECAM1 THBS1
13 nervous system MP:0003631 9.96 CAMTA1 ENG FGF2 FLI1 FLT1 KDR
14 neoplasm MP:0002006 9.92 CAMTA1 CD248 CD34 FGF2 FLI1 KIT
15 normal MP:0002873 9.81 CAMTA1 CD248 ENG FLT1 FLT4 KDR
16 reproductive system MP:0005389 9.61 ANPEP CAMTA1 FGF2 FLT1 FLT4 KIT
17 vision/eye MP:0005391 9.23 ANPEP FGF2 FLT1 KDR KIT PDGFRB

Drugs & Therapeutics for Vascular Cancer

Drugs for Vascular Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 6055-19-2, 50-18-0 2907
2
Propranolol Approved, Investigational Phase 1, Phase 2 525-66-6 4946
3 Adrenergic beta-Antagonists Phase 1, Phase 2
4 Anti-Arrhythmia Agents Phase 1, Phase 2
5 Adrenergic Agents Phase 1, Phase 2
6 Neurotransmitter Agents Phase 1, Phase 2
7 Antihypertensive Agents Phase 1, Phase 2
8 Vasodilator Agents Phase 1, Phase 2
9 Adrenergic Antagonists Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dose-Finding of Propranolol in Combination With Metronomic Fixed Oral Cyclophosphamide Based on Bivariate Efficacy-tolerability Outcome in Patients With Locally Advanced or Metastatic Angiosarcoma: A Collaborative and Innovative Phase I-II Sequential Trial by the French Sarcoma Group (GSF/GETO) Not yet recruiting NCT02732678 Phase 1, Phase 2 PROPRANOLOL

Search NIH Clinical Center for Vascular Cancer

Cochrane evidence based reviews: vascular neoplasms

Genetic Tests for Vascular Cancer

Anatomical Context for Vascular Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Vascular Cancer:

20
Blood Vessels

MalaCards organs/tissues related to Vascular Cancer:

42
Endothelial, Cerebellum

Publications for Vascular Cancer

Articles related to Vascular Cancer:

# Title Authors Year
1
Research gives hope to patients with rare vascular cancer. Cleveland Clinic researchers suggest that their work could lead to breakthrough in treating other cancers. ( 22272406 )
2011
2
Cutaneous reactive angiomatosis occurring in erythema ab igne can cause atypia in endothelial cells: potential mimic of malignant vascular neoplasm. ( 15982219 )
2005
3
New strategies in anti-vascular cancer therapy. ( 10469169 )
1999
4
Anti-vascular cancer therapy: is it a dream or reality? ( 1720044 )
1991
5
Radiation effects of neutron-capture therapy on a malignant vascular neoplasm of the cerebellum; histopathologcal observations. ( 14417402 )
1960

Variations for Vascular Cancer

Expression for Vascular Cancer

Search GEO for disease gene expression data for Vascular Cancer.

Pathways for Vascular Cancer

Pathways related to Vascular Cancer according to GeneCards Suite gene sharing:

(show all 47)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.48 FGF2 FLT1 FLT4 KDR KIT PDGFRB
2
Show member pathways
13.26 FGF2 FLT1 FLT4 KDR KIT PDGFRB
3
Show member pathways
13.23 FGF2 FLT1 FLT4 KDR KIT PDGFRB
4
Show member pathways
13.22 FGF2 FLT1 FLT4 KDR KIT PDGFRB
5
Show member pathways
13.02 FGF2 FLT1 FLT4 KDR KIT PDGFRB
6
Show member pathways
13.01 FGF2 FLT1 FLT4 KDR KIT PDGFRB
7
Show member pathways
12.92 FLT1 FLT4 KDR KIT PDGFRB
8
Show member pathways
12.82 FLT1 FLT4 KDR PDGFRB THBS1 VEGFA
9 12.78 FGF2 FLT4 KIT PDGFRB VEGFA
10 12.67 FGF2 FLT1 FLT4 KDR KIT PDGFRB
11
Show member pathways
12.64 FGF2 FLT1 FLT4 KDR KIT PDGFRB
12 12.5 CD34 FLI1 KIT PECAM1
13
Show member pathways
12.5 FGF2 FLT1 FLT4 KDR KIT PDGFRB
14
Show member pathways
12.44 FLT1 FLT4 KDR PDGFRB
15
Show member pathways
12.39 FLT1 FLT4 KDR PDGFRB
16
Show member pathways
12.36 FLT1 FLT4 KDR VEGFA
17
Show member pathways
12.34 FGF2 FLT1 FLT4 KDR VEGFA
18
Show member pathways
12.32 FGF2 FLT1 FLT4 KDR KIT PDGFRB
19 12.26 FGF2 KDR THBS1 VEGFA
20
Show member pathways
12.21 FGF2 FLT1 FLT4 KDR KIT PDGFRB
21
Show member pathways
12.19 FGF2 FLT1 KDR VEGFA
22
Show member pathways
12.16 FLT1 FLT4 KDR PDGFRB
23 12.1 FLT1 FLT4 KDR PDGFRB
24
Show member pathways
12.09 KDR PECAM1 THBS1 VWF
25 12.03 FGF2 KDR PDGFRB VEGFA
26
Show member pathways
12.01 FGF2 FLT1 FLT4 KDR
27 11.97 FGF2 FLT1 FLT4 KDR KIT PDGFRB
28 11.95 ANPEP CD34 ENG KIT
29
Show member pathways
11.94 FLT1 KDR PDGFRB VEGFA
30 11.84 ANPEP CD34 KIT
31
Show member pathways
11.8 FLT1 FLT4 KDR VEGFA
32 11.73 ANPEP CD34 KIT
33
Show member pathways
11.72 FLT1 FLT4 KDR KIT PDGFRB
34
Show member pathways
11.65 FLT1 FLT4 KDR KIT PDGFRB
35 11.52 ANPEP FGF2 KDR KIT
36 11.51 FGF2 KDR VEGFA
37 11.49 FGF2 KIT VEGFA
38 11.46 FGF2 KDR VEGFA
39
Show member pathways
11.42 KDR PDGFRB VEGFA
40 11.31 FLT1 KDR VEGFA
41 11.23 ENG FGF2 FLT1 FLT4 KDR PDGFRB
42 11.16 FGF2 FLT1 VEGFA
43 11.11 FGF2 FLT1 KDR VEGFA
44 11.07 FGF2 FLT1 FLT4 KDR PDGFRB VEGFA
45 11.02 FGF2 FLT1 FLT4 KDR VEGFA
46 10.97 SERPINA3 VEGFA
47 10.97 FGF2 FLT1 FLT4 KDR KIT PDGFRB

GO Terms for Vascular Cancer

Cellular components related to Vascular Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.91 ANPEP ENG FGF2 FLT1 KIT PECAM1
2 cell surface GO:0009986 9.8 CD34 ENG KIT PDGFRB THBS1 VEGFA
3 extracellular matrix GO:0031012 9.58 CD248 THBS1 VEGFA
4 platelet alpha granule lumen GO:0031093 9.46 SERPINA3 THBS1 VEGFA VWF
5 platelet alpha granule GO:0031091 9.43 THBS1 VWF
6 receptor complex GO:0043235 9.43 ENG FLT1 FLT4 KDR KIT PDGFRB
7 external side of plasma membrane GO:0009897 9.17 ANPEP CD248 CD34 ENG KIT PECAM1
8 extracellular region GO:0005576 10.02 CD34 FGF2 FLT1 FLT4 KDR SERPINA3

Biological processes related to Vascular Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.99 CD34 ENG KDR VEGFA
2 positive regulation of protein kinase B signaling GO:0051897 9.99 ENG FGF2 KIT PDGFRB THBS1
3 positive regulation of cell migration GO:0030335 9.99 FLT1 KDR KIT PDGFRB THBS1 VEGFA
4 negative regulation of apoptotic process GO:0043066 9.98 FLT4 KDR PDGFRB THBS1 VEGFA
5 cell migration GO:0016477 9.96 CD248 FLT1 PDGFRB THBS1
6 positive regulation of MAPK cascade GO:0043410 9.96 FLT1 FLT4 KDR KIT PDGFRB
7 positive regulation of protein phosphorylation GO:0001934 9.95 ENG FLT4 KDR VEGFA
8 platelet degranulation GO:0002576 9.95 PECAM1 SERPINA3 THBS1 VEGFA VWF
9 positive regulation of endothelial cell proliferation GO:0001938 9.92 FGF2 FLT4 KDR VEGFA
10 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.91 FLT1 KDR KIT PDGFRB
11 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.91 FLT1 FLT4 KDR VEGFA
12 cell differentiation GO:0030154 9.91 ANPEP FGF2 FLI1 FLT1 KDR VEGFA
13 activation of MAPK activity GO:0000187 9.89 FGF2 KIT THBS1
14 phosphatidylinositol phosphorylation GO:0046854 9.89 FGF2 KIT PDGFRB
15 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.89 FLT1 FLT4 KDR KIT PDGFRB
16 positive regulation of endothelial cell migration GO:0010595 9.88 FLT4 KDR THBS1 VEGFA
17 peptidyl-tyrosine phosphorylation GO:0018108 9.88 FGF2 FLT1 FLT4 KDR KIT PDGFRB
18 wound healing GO:0042060 9.87 FGF2 PDGFRB PECAM1
19 positive regulation of blood vessel endothelial cell migration GO:0043536 9.87 FGF2 KDR THBS1 VEGFA
20 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.85 KIT PECAM1 VEGFA
21 vasculogenesis GO:0001570 9.83 ENG KDR VEGFA
22 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.83 FLT1 FLT4 KDR VEGFA
23 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.82 FGF2 KDR VEGFA
24 positive regulation of cell proliferation GO:0008284 9.81 CD248 FGF2 FLT1 FLT4 KDR KIT
25 cell migration involved in sprouting angiogenesis GO:0002042 9.8 FGF2 KDR VEGFA
26 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.78 FGF2 FLT1 KIT PDGFRB
27 positive regulation of MAP kinase activity GO:0043406 9.77 FGF2 FLT1 KIT PDGFRB VEGFA
28 sprouting angiogenesis GO:0002040 9.76 ENG FLT4 THBS1 VEGFA
29 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.72 FLT1 VEGFA
30 embryonic hemopoiesis GO:0035162 9.71 KDR KIT
31 embryonic morphogenesis GO:0048598 9.71 FGF2 FLT1
32 megakaryocyte development GO:0035855 9.7 FLI1 KIT
33 positive regulation of DNA biosynthetic process GO:2000573 9.7 FGF2 PDGFRB
34 positive regulation of chemotaxis GO:0050921 9.7 PDGFRB THBS1
35 positive regulation of positive chemotaxis GO:0050927 9.69 KDR VEGFA
36 positive regulation of vasculogenesis GO:2001214 9.68 CD34 KDR
37 positive regulation of transforming growth factor beta production GO:0071636 9.68 CD34 THBS1
38 stem cell proliferation GO:0072089 9.68 CD34 FGF2
39 positive regulation of protein kinase C signaling GO:0090037 9.67 FLT4 VEGFA
40 positive regulation of vascular smooth muscle cell differentiation GO:1905065 9.67 ENG KIT
41 paracrine signaling GO:0038001 9.67 CD34 FGF2
42 endothelium development GO:0003158 9.65 CD34 KDR
43 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.65 KDR VEGFA
44 glomerular endothelium development GO:0072011 9.64 CD34 PECAM1
45 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 9.63 PDGFRB VEGFA
46 vascular endothelial growth factor signaling pathway GO:0038084 9.62 FLT1 FLT4 KDR VEGFA
47 positive regulation of phospholipase C activity GO:0010863 9.56 FGF2 FLT1 KIT PDGFRB
48 positive regulation of angiogenesis GO:0045766 9.5 CD34 ENG FGF2 FLT1 KDR THBS1
49 angiogenesis GO:0001525 9.23 ANPEP ENG FGF2 FLT1 FLT4 KDR
50 multicellular organism development GO:0007275 10.19 ANPEP FGF2 FLT1 KDR PDGFRB VEGFA

Molecular functions related to Vascular Cancer according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.93 FLT1 FLT4 KDR KIT PDGFRB
2 protein homodimerization activity GO:0042803 9.93 ENG FLT4 KIT PECAM1 VEGFA VWF
3 protein kinase activity GO:0004672 9.89 FLT1 FLT4 KDR KIT PDGFRB
4 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.7 FGF2 KIT PDGFRB
5 integrin binding GO:0005178 9.67 FGF2 KDR THBS1 VWF
6 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.65 FGF2 KIT PDGFRB
7 growth factor binding GO:0019838 9.58 FLT1 FLT4 KDR
8 platelet-derived growth factor receptor binding GO:0005161 9.51 PDGFRB VEGFA
9 extracellular matrix binding GO:0050840 9.5 CD248 THBS1 VEGFA
10 vascular endothelial growth factor binding GO:0038085 9.43 KDR PDGFRB
11 vascular endothelial growth factor-activated receptor activity GO:0005021 9.43 FLT1 FLT4 KDR
12 protein tyrosine kinase activity GO:0004713 9.43 FGF2 FLT1 FLT4 KDR KIT PDGFRB
13 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.02 FLT1 FLT4 KDR KIT PDGFRB
14 transmembrane signaling receptor activity GO:0004888 8.85 ENG

Sources for Vascular Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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