MCID: VSC006
MIFTS: 51

Vascular Cancer

Categories: Blood diseases, Cancer diseases, Cardiovascular diseases, Nephrological diseases

Aliases & Classifications for Vascular Cancer

MalaCards integrated aliases for Vascular Cancer:

Name: Vascular Cancer 12 15
Malignant Vascular Neoplasm 12 73
Renal Vein Leiomyosarcoma 12 73
Blood Vessel Tumors 12 55
Vascular Neoplasms 44 73
Malignant Tumor of Pulmonary Artery 12
Pulmonary Artery Malignant Neoplasm 12
Malignant Neoplasm of Great Vessels 73
Malignant Tumor of Pulmonary Vein 12
Pulmonary Vein Malignant Neoplasm 12
Leiomyosarcoma of the Renal Vein 12
Blood Vessel Tumour Disorder 12
Malignant Great Vessel Tumor 12
Neoplasms, Vascular Tissue 73
Malignant Vascular Tumor 12
Neoplasm of Great Vessel 12
Vascular Tissue Neoplasm 12
Haemangiomatous Tumour 12
Blood Vessel Neoplasm 12
Blood Vessel Cancer 73
Blood Vessel Tumor 12
Vascular Tumors 12

Classifications:



Summaries for Vascular Cancer

Disease Ontology : 12 A cardiovascular cancer that is located in blood vessels.

MalaCards based summary : Vascular Cancer, also known as malignant vascular neoplasm, is related to ovarian angiosarcoma and kaposiform hemangioendothelioma. An important gene associated with Vascular Cancer is FLT4 (Fms Related Tyrosine Kinase 4), and among its related pathways/superpathways are TGF-Beta Pathway and CREB Pathway. Affiliated tissues include skin, brain and liver, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Vascular Cancer

Diseases related to Vascular Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
# Related Disease Score Top Affiliating Genes
1 ovarian angiosarcoma 31.8 CD34 HBA1
2 kaposiform hemangioendothelioma 31.4 CD34 FLI1 FLT4 KDR PROX1 VWF
3 breast angiosarcoma 31.3 CD34 HBA1 KIT
4 juvenile nasopharyngeal angiofibroma 31.3 ENG FGF2 KIT VEGFA
5 glomeruloid hemangioma 31.2 CD34 ENG FLT1 HBA1 VEGFA
6 histiocytoid hemangioma 29.9 CAMTA1 HBA1
7 skin epithelioid hemangioma 29.8 CD34 HBA1
8 capillary hemangioma 29.8 FLT1 HBA1 KDR VEGFA
9 epithelioid hemangioendothelioma 29.7 CAMTA1 FLT1 KDR VEGFA
10 kaposi sarcoma 29.6 FGF2 KDR VEGFA
11 hemangioendothelioma 29.6 CAMTA1 FLI1 FLT4 KDR
12 renal cell carcinoma, nonpapillary 29.6 FGF2 FLT1 FLT4 KDR KIT PDGFRB
13 retinal vascular disease 29.3 FLT1 HBA1 KDR VEGFA
14 venous hemangioma 29.3 CD34 HBA1
15 hemangioma 28.8 CD34 FGF2 FLT1 FLT4 KDR PROX1
16 angiosarcoma 28.7 FLI1 FLT1 FLT4 KDR KIT PROX1
17 hemangioma-thrombocytopenia syndrome 11.4
18 angioma, tufted 11.2
19 hemangioblastoma 11.2
20 littoral cell angioma of the spleen 11.2
21 hemangioma, capillary infantile 11.1
22 meningioma, familial 10.9
23 skin angiosarcoma 10.9
24 brain stem angioblastoma 10.9
25 carotid body cancer 10.9
26 hemifacial spasm 10.3 FLT4 VEGFA
27 bone squamous cell carcinoma 10.2 ENG KDR
28 infiltrating angiolipoma 10.2 VEGFA VWF
29 breast carcinoma in situ 10.2 FLT4 KDR VEGFA
30 radiation proctitis 10.2 FGF2 KDR VEGFA
31 posterior uveal melanoma 10.2 THBS1 VEGFA
32 angiokeratoma circumscriptum 10.2 FLT1 KDR VEGFA
33 hypoglycemic coma 10.2 HBA1 VEGFA
34 microcystic meningioma 10.2 FLT1 VEGFA
35 placental insufficiency 10.2 FLT1 KDR VEGFA
36 exudative vitreoretinopathy 1 10.2 FLT1 KDR VEGFA
37 cellular neurofibroma 10.1 CD34 PDGFRB
38 microvascular complications of diabetes 1 10.1 FGF2 FLT1 VEGFA
39 chronic myocardial ischemia 10.1 FGF2 VEGFA
40 arteries, anomalies of 10.1 FLT1 VEGFA VWF
41 ovary sarcoma 10.1 CD34 HBA1
42 intravascular fasciitis 10.1 CD34 HBA1
43 thyroid angiosarcoma 10.1 CD34 HBA1
44 bone epithelioid hemangioma 10.1 CD34 HBA1
45 hellp syndrome 10.1 ENG FLT1 VWF
46 thyroid sarcoma 10.1 CD34 HBA1
47 leiomyosarcoma 10.1
48 hordeolum 10.1 CD34 HBA1
49 microvascular complications of diabetes 5 10.1 FGF2 FLT1 KDR VEGFA
50 hemangioma of liver 10.1 CD34 HBA1

Graphical network of the top 20 diseases related to Vascular Cancer:



Diseases related to Vascular Cancer

Symptoms & Phenotypes for Vascular Cancer

MGI Mouse Phenotypes related to Vascular Cancer:

46 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.38 ANPEP ENG FGF2 FLI1 FLT1 FLT4
2 hematopoietic system MP:0005397 10.32 ANPEP CD34 ENG FGF2 FLI1 FLT1
3 cellular MP:0005384 10.3 CD34 FGF2 FLI1 FLT1 KDR KIT
4 homeostasis/metabolism MP:0005376 10.27 CD34 ENG FGF2 FLT1 FLT4 KDR
5 growth/size/body region MP:0005378 10.26 CAMTA1 ENG FLI1 FLT1 FLT4 KDR
6 immune system MP:0005387 10.26 ANPEP CD34 FLI1 FLT1 FLT4 KDR
7 behavior/neurological MP:0005386 10.23 CAMTA1 ENG FGF2 FLT1 KDR KIT
8 mortality/aging MP:0010768 10.22 CAMTA1 ENG FGF2 FLI1 FLT1 FLT4
9 digestive/alimentary MP:0005381 10.15 ENG FLT4 KIT PDGFRB PROX1 THBS1
10 embryo MP:0005380 10.14 ENG FLI1 FLT1 FLT4 KDR KIT
11 integument MP:0010771 10.11 ANPEP CD34 ENG FLT4 KDR KIT
12 muscle MP:0005369 10.11 ENG FGF2 FLI1 FLT1 FLT4 KDR
13 nervous system MP:0003631 10 CAMTA1 ENG FGF2 FLI1 FLT1 KDR
14 liver/biliary system MP:0005370 9.98 FLI1 FLT4 KDR KIT PROX1 THBS1
15 neoplasm MP:0002006 9.87 CAMTA1 CD34 FGF2 FLI1 KIT THBS1
16 normal MP:0002873 9.81 CAMTA1 ENG FLT1 FLT4 KDR KIT
17 reproductive system MP:0005389 9.61 ANPEP CAMTA1 FGF2 FLT1 FLT4 KIT
18 vision/eye MP:0005391 9.28 ANPEP FGF2 FLT1 KDR KIT PDGFRB

Drugs & Therapeutics for Vascular Cancer

Search Clinical Trials , NIH Clinical Center for Vascular Cancer

Cochrane evidence based reviews: vascular neoplasms

Genetic Tests for Vascular Cancer

Anatomical Context for Vascular Cancer

MalaCards organs/tissues related to Vascular Cancer:

41
Skin, Brain, Liver, Bone, Spleen, Thyroid, Small Intestine

The Foundational Model of Anatomy Ontology organs/tissues related to Vascular Cancer:

19
Blood Vessels

Publications for Vascular Cancer

Articles related to Vascular Cancer:

# Title Authors Year
1
Research gives hope to patients with rare vascular cancer. Cleveland Clinic researchers suggest that their work could lead to breakthrough in treating other cancers. ( 22272406 )
2011
2
Cutaneous reactive angiomatosis occurring in erythema ab igne can cause atypia in endothelial cells: potential mimic of malignant vascular neoplasm. ( 15982219 )
2005
3
New strategies in anti-vascular cancer therapy. ( 10469169 )
1999
4
Anti-vascular cancer therapy: is it a dream or reality? ( 1720044 )
1991
5
Radiation effects of neutron-capture therapy on a malignant vascular neoplasm of the cerebellum; histopathologcal observations. ( 14417402 )
1960

Variations for Vascular Cancer

Expression for Vascular Cancer

Search GEO for disease gene expression data for Vascular Cancer.

Pathways for Vascular Cancer

Pathways related to Vascular Cancer according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.47 FGF2 FLT1 FLT4 KDR KIT PDGFRB
2
Show member pathways
13.25 FGF2 FLT1 FLT4 KDR KIT PDGFRB
3
Show member pathways
13.23 FGF2 FLT1 FLT4 KDR KIT PDGFRB
4
Show member pathways
13.21 FGF2 FLT1 FLT4 KDR KIT PDGFRB
5
Show member pathways
13.02 FGF2 FLT1 FLT4 KDR KIT PDGFRB
6
Show member pathways
13.01 FGF2 FLT1 FLT4 KDR KIT PDGFRB
7
Show member pathways
12.92 FLT1 FLT4 KDR KIT PDGFRB
8
Show member pathways
12.82 FLT1 FLT4 KDR PDGFRB THBS1 VEGFA
9 12.78 FGF2 FLT4 KIT PDGFRB VEGFA
10 12.69 FGF2 FLT1 FLT4 KDR KIT PDGFRB
11
Show member pathways
12.65 FGF2 FLT1 FLT4 KDR KIT PDGFRB
12
Show member pathways
12.5 FGF2 FLT1 FLT4 KDR KIT PDGFRB
13
Show member pathways
12.44 FLT1 FLT4 KDR PDGFRB
14
Show member pathways
12.39 FLT1 FLT4 KDR PDGFRB
15
Show member pathways
12.36 FLT1 FLT4 KDR VEGFA
16
Show member pathways
12.35 FGF2 FLT1 FLT4 KDR VEGFA
17
Show member pathways
12.33 FGF2 FLT1 FLT4 KDR KIT PDGFRB
18 12.26 FGF2 KDR THBS1 VEGFA
19
Show member pathways
12.23 FGF2 FLT1 FLT4 KDR KIT PDGFRB
20
Show member pathways
12.19 FGF2 FLT1 KDR VEGFA
21
Show member pathways
12.16 FLT1 FLT4 KDR PDGFRB
22 12.11 FLT1 FLT4 KDR PDGFRB
23 12.02 FGF2 KDR PDGFRB PROX1 VEGFA
24 12.02 FGF2 FLT1 FLT4 KDR KIT PDGFRB
25
Show member pathways
12.01 FGF2 FLT1 FLT4 KDR
26 11.97 ANPEP CD34 ENG KIT
27
Show member pathways
11.96 FLT1 KDR PDGFRB VEGFA
28 11.84 ANPEP CD34 KIT
29
Show member pathways
11.83 FLT1 FLT4 KDR VEGFA
30
Show member pathways
11.75 FLT1 FLT4 KDR KIT PDGFRB
31 11.73 ANPEP CD34 KIT
32
Show member pathways
11.69 FLT1 FLT4 KDR KIT PDGFRB
33 11.56 ANPEP FGF2 KDR KIT
34 11.51 FGF2 KDR VEGFA
35 11.49 FGF2 KIT VEGFA
36 11.47 FGF2 KDR VEGFA
37
Show member pathways
11.42 KDR PDGFRB VEGFA
38 11.32 FLT1 KDR VEGFA
39 11.23 ENG FGF2 FLT1 FLT4 KDR PDGFRB
40 11.17 FGF2 FLT1 VEGFA
41 11.14 FGF2 FLT1 KDR VEGFA
42 11.07 FGF2 FLT1 FLT4 KDR VEGFA
43 11.06 FGF2 FLT1 FLT4 KDR PDGFRB VEGFA
44 10.97 FGF2 FLT1 FLT4 KDR KIT PDGFRB
45
Show member pathways
10.83 FLT1 FLT4 KDR VEGFA

GO Terms for Vascular Cancer

Cellular components related to Vascular Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.92 ANPEP ENG FGF2 FLT1 HBA1 KIT
2 extracellular region GO:0005576 9.91 CD34 FGF2 FLT1 FLT4 HBA1 KDR
3 external side of plasma membrane GO:0009897 9.55 ANPEP CD34 ENG KIT THBS1
4 platelet alpha granule lumen GO:0031093 9.54 THBS1 VEGFA VWF
5 cell surface GO:0009986 9.43 CD34 ENG KIT PDGFRB THBS1 VEGFA
6 platelet alpha granule GO:0031091 9.4 THBS1 VWF
7 receptor complex GO:0043235 9.1 ENG FLT1 FLT4 KDR KIT PDGFRB

Biological processes related to Vascular Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.99 CD34 ENG KDR VEGFA
2 positive regulation of MAPK cascade GO:0043410 9.97 FLT1 FLT4 KDR KIT PDGFRB
3 negative regulation of signal transduction GO:0009968 9.97 FLT1 FLT4 KDR KIT PDGFRB
4 extracellular matrix organization GO:0030198 9.96 FGF2 KDR THBS1 VWF
5 positive regulation of protein phosphorylation GO:0001934 9.94 ENG FLT4 KDR VEGFA
6 peptidyl-tyrosine phosphorylation GO:0018108 9.93 FGF2 FLT1 FLT4 KDR KIT PDGFRB
7 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.92 FLT1 KDR KIT PDGFRB
8 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.91 FLT1 FLT4 KDR VEGFA
9 platelet degranulation GO:0002576 9.9 THBS1 VEGFA VWF
10 activation of MAPK activity GO:0000187 9.89 FGF2 KIT THBS1
11 phosphatidylinositol phosphorylation GO:0046854 9.89 FGF2 KIT PDGFRB
12 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.89 FLT1 FLT4 KDR KIT PDGFRB
13 positive regulation of blood vessel endothelial cell migration GO:0043536 9.88 FGF2 KDR THBS1 VEGFA
14 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.85 FLT1 FLT4 KDR VEGFA
15 vasculogenesis GO:0001570 9.83 ENG KDR VEGFA
16 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.83 FGF2 FLT1 KIT PDGFRB
17 positive regulation of endothelial cell proliferation GO:0001938 9.83 FGF2 FLT4 KDR PROX1 VEGFA
18 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.81 FGF2 KDR VEGFA
19 sprouting angiogenesis GO:0002040 9.81 ENG FLT4 THBS1 VEGFA
20 cell migration involved in sprouting angiogenesis GO:0002042 9.8 FGF2 KDR VEGFA
21 positive regulation of MAP kinase activity GO:0043406 9.8 FGF2 FLT1 KIT PDGFRB VEGFA
22 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.72 FLT1 VEGFA
23 positive regulation of endothelial cell migration GO:0010595 9.72 FLT4 KDR PROX1 THBS1 VEGFA
24 embryonic hemopoiesis GO:0035162 9.71 KDR KIT
25 embryonic morphogenesis GO:0048598 9.71 FGF2 FLT1
26 megakaryocyte development GO:0035855 9.71 FLI1 KIT
27 positive regulation of DNA biosynthetic process GO:2000573 9.71 FGF2 PDGFRB
28 positive regulation of chemotaxis GO:0050921 9.7 PDGFRB THBS1
29 lymph vessel development GO:0001945 9.7 FLT4 PROX1
30 angiogenesis GO:0001525 9.7 ANPEP ENG FGF2 FLT1 FLT4 KDR
31 lymphangiogenesis GO:0001946 9.69 FLT4 PROX1
32 positive regulation of positive chemotaxis GO:0050927 9.69 KDR VEGFA
33 positive regulation of vasculogenesis GO:2001214 9.69 CD34 KDR
34 positive regulation of transforming growth factor beta production GO:0071636 9.68 CD34 THBS1
35 stem cell proliferation GO:0072089 9.68 CD34 FGF2
36 positive regulation of protein kinase C signaling GO:0090037 9.68 FLT4 VEGFA
37 positive regulation of vascular smooth muscle cell differentiation GO:1905065 9.67 ENG KIT
38 paracrine signaling GO:0038001 9.67 CD34 FGF2
39 venous blood vessel morphogenesis GO:0048845 9.67 ENG PROX1
40 vascular endothelial growth factor signaling pathway GO:0038084 9.67 FLT1 FLT4 KDR VEGFA
41 atrial cardiac muscle tissue morphogenesis GO:0055009 9.65 ENG PROX1
42 endothelium development GO:0003158 9.65 CD34 KDR
43 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.65 KDR VEGFA
44 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 9.63 PDGFRB VEGFA
45 positive regulation of cell proliferation GO:0008284 9.61 FGF2 FLT1 FLT4 KDR KIT PDGFRB
46 positive regulation of phospholipase C activity GO:0010863 9.56 FGF2 FLT1 KIT PDGFRB
47 positive regulation of angiogenesis GO:0045766 9.17 CD34 ENG FGF2 FLT1 KDR THBS1
48 positive regulation of transcription by RNA polymerase II GO:0045944 10.18 CAMTA1 ENG FGF2 FLI1 PROX1 VEGFA
49 multicellular organism development GO:0007275 10.18 ANPEP FGF2 FLT1 KDR PDGFRB PROX1
50 negative regulation of apoptotic process GO:0043066 10.14 FLT1 FLT4 KDR KIT PDGFRB THBS1

Molecular functions related to Vascular Cancer according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.89 FLT1 FLT4 KDR KIT PDGFRB
2 protein kinase activity GO:0004672 9.85 FLT1 FLT4 KDR KIT PDGFRB
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.69 FGF2 KIT PDGFRB
4 transmembrane signaling receptor activity GO:0004888 9.63 ENG FLT1 FLT4 KDR KIT PDGFRB
5 integrin binding GO:0005178 9.62 FGF2 KDR THBS1 VWF
6 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.61 FGF2 KIT PDGFRB
7 growth factor binding GO:0019838 9.54 FLT1 FLT4 KDR
8 transforming growth factor beta binding GO:0050431 9.52 ENG THBS1
9 platelet-derived growth factor receptor binding GO:0005161 9.48 PDGFRB VEGFA
10 vascular endothelial growth factor-activated receptor activity GO:0005021 9.43 FLT1 FLT4 KDR
11 protein tyrosine kinase activity GO:0004713 9.43 FGF2 FLT1 FLT4 KDR KIT PDGFRB
12 vascular endothelial growth factor binding GO:0038085 9.4 KDR PDGFRB
13 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.02 FLT1 FLT4 KDR KIT PDGFRB

Sources for Vascular Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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