MCID: VSC006
MIFTS: 46

Vascular Cancer

Categories: Cancer diseases, Cardiovascular diseases

Aliases & Classifications for Vascular Cancer

MalaCards integrated aliases for Vascular Cancer:

Name: Vascular Cancer 12 15
Malignant Vascular Neoplasm 12 70
Renal Vein Leiomyosarcoma 12 70
Blood Vessel Tumors 12 54
Vascular Neoplasms 44 70
Malignant Tumor of Pulmonary Artery 12
Pulmonary Artery Malignant Neoplasm 12
Malignant Neoplasm of Great Vessels 70
Malignant Tumor of Pulmonary Vein 12
Pulmonary Vein Malignant Neoplasm 12
Leiomyosarcoma of the Renal Vein 12
Blood Vessel Tumour Disorder 12
Malignant Great Vessel Tumor 12
Neoplasms, Vascular Tissue 70
Malignant Vascular Tumor 12
Neoplasm of Great Vessel 12
Vascular Tissue Neoplasm 12
Haemangiomatous Tumour 12
Blood Vessel Neoplasm 12
Blood Vessel Cancer 70
Blood Vessel Tumor 12
Vascular Tumors 12

Classifications:



External Ids:

Disease Ontology 12 DOID:175
MeSH 44 D019043
SNOMED-CT 67 126737003 93817006
UMLS 70 C0027668 C0282607 C0346845 more

Summaries for Vascular Cancer

Disease Ontology : 12 A cardiovascular cancer that is located in blood vessels.

MalaCards based summary : Vascular Cancer, also known as malignant vascular neoplasm, is related to ovarian angiosarcoma and aortic malignant tumor. An important gene associated with Vascular Cancer is FLT4 (Fms Related Receptor Tyrosine Kinase 4), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Focal Adhesion. The drugs Pembrolizumab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include blood vessels, endothelial and breast, and related phenotypes are hematopoietic system and cardiovascular system

Related Diseases for Vascular Cancer

Diseases related to Vascular Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 395)
# Related Disease Score Top Affiliating Genes
1 ovarian angiosarcoma 32.3 PECAM1 CD34
2 aortic malignant tumor 32.0 PECAM1 CD34
3 kaposiform hemangioendothelioma 32.0 VWF PECAM1 KDR FLT4 FLI1 CD34
4 meningioma, familial 31.8 VEGFA SERPINA3 PDGFRB FLT1 CD34
5 leiomyosarcoma 31.3 VEGFA SERPINA3 PECAM1 PDGFRB MLANA
6 angiosarcoma 31.1 VWF VEGFA PECAM1 MLANA KDR FLT4
7 epithelioid hemangioendothelioma 31.1 VEGFA TFE3 KDR FLT1 CAMTA1
8 arteriovenous malformation 31.0 VEGFA THBS1 ENG
9 histiocytoid hemangioma 30.8 TFE3 PECAM1 CD34 CAMTA1
10 capillary hemangioma 30.6 VEGFA PECAM1 KDR FLT4 FLT1 FGF2
11 lymphangioma 30.6 VEGFA SERPINA3 PECAM1 KDR IFNA2 FLT4
12 kaposi sarcoma 30.5 VEGFA IFNA2 FGF2 CD34
13 glomangioma 30.5 PECAM1 CD34
14 hemangioma of spleen 30.5 PECAM1 CD34
15 spindle cell sarcoma 30.4 VEGFA SERPINA3 CD34
16 malignant hemangioma 30.4 SERPINA3 CAMTA1
17 intramuscular hemangioma 30.4 PECAM1 CD34
18 lymphangiosarcoma 30.4 VWF PECAM1 FLT4 CD34
19 hemangiopericytoma, malignant 30.4 SERPINA3 PECAM1 CD34
20 portal hypertension 30.4 VWF VEGFA PECAM1
21 angiolipoma 30.3 PECAM1 MLANA CD34
22 mesenchymal cell neoplasm 30.3 TFE3 SERPINA3 PECAM1 PDGFRB MLANA CD34
23 malignant epithelioid hemangioendothelioma 30.3 TFE3 SERPINA3 CAMTA1
24 breast angiosarcoma 30.3 PECAM1 KDR FLT4 CD34
25 fibrous histiocytoma 30.3 SERPINA3 PECAM1 CD34
26 cavernous hemangioma 30.3 PECAM1 KDR FGF2 CD34
27 hemangioblastoma 30.3 VEGFA PECAM1 PDGFRB KDR CD34
28 kidney cancer 30.2 VEGFA KDR IFNA2 FLT4 FGF2
29 juvenile nasopharyngeal angiofibroma 30.2 VEGFA PECAM1 FGF2 ENG
30 intravascular papillary endothelial hyperplasia 30.2 VEGFA SERPINA3
31 hemangioendothelioma 30.2 PLG FLT4 FLI1 CD34 CAMTA1
32 bacillary angiomatosis 30.2 VEGFA PECAM1 CD34
33 retinal vascular disease 30.1 VEGFA PLG KDR FLT1 FGF2
34 sarcoma 30.1 VEGFA TFE3 KDR FLT4 FLI1 FGF2
35 varicose veins 30.1 VWF VEGFA KDR
36 angiodysplasia 30.1 VWF VEGFA FGF2 ENG
37 cystic lymphangioma 30.1 SERPINA3 PECAM1 CD34
38 mesothelioma, malignant 30.1 PDGFRB KDR FLT4 FGF2
39 dermatofibrosarcoma protuberans 30.0 SERPINA3 PDGFRB CD34
40 cerebral cavernous malformations 30.0 PECAM1 KDR FLT1 ENG
41 sarcomatoid squamous cell skin carcinoma 30.0 SERPINA3 PECAM1 MLANA CD34
42 glomeruloid hemangioma 29.9 VEGFA PECAM1 FLT1 ENG CD34
43 connective tissue benign neoplasm 29.9 SERPINA3 PECAM1 PDGFRB MLANA CD34
44 eye disease 29.8 VEGFA SERPINA3 KDR FLT4 FLT1 FGF2
45 thrombocytopenia 29.8 VWF THBS1 PLG PECAM1 IFNA2 FLI1
46 wilms tumor 1 29.8 VEGFA THBS1 SERPINA3 FLT1 FLI1 CD34
47 gliosarcoma 29.7 VEGFA SERPINA3 PECAM1 PDGFRB KDR FGF2
48 renal cell carcinoma, nonpapillary 29.7 VEGFA THBS1 TFE3 PECAM1 PDGFRB KDR
49 ewing sarcoma 29.6 VEGFA PDGFRB KDR FLI1
50 melanoma 29.5 VEGFA THBS1 PDGFRB MLANA KDR IFNA2

Graphical network of the top 20 diseases related to Vascular Cancer:



Diseases related to Vascular Cancer

Symptoms & Phenotypes for Vascular Cancer

MGI Mouse Phenotypes related to Vascular Cancer:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.33 ANPEP CD248 CD34 ENG FGF2 FLI1
2 cardiovascular system MP:0005385 10.31 ANPEP ENG FGF2 FLI1 FLT1 FLT4
3 homeostasis/metabolism MP:0005376 10.28 CD248 CD34 ENG FGF2 FLT1 FLT4
4 immune system MP:0005387 10.25 ANPEP CD248 CD34 FLI1 FLT1 FLT4
5 integument MP:0010771 10.18 ANPEP CD248 CD34 ENG FLT4 KDR
6 digestive/alimentary MP:0005381 10.08 ENG FLT4 PDGFRB PECAM1 PLG THBS1
7 muscle MP:0005369 10.02 ENG FGF2 FLI1 FLT1 FLT4 KDR
8 neoplasm MP:0002006 9.86 CAMTA1 CD248 CD34 FGF2 FLI1 PLG
9 normal MP:0002873 9.81 CAMTA1 CD248 ENG FLT1 FLT4 KDR
10 reproductive system MP:0005389 9.65 ANPEP CAMTA1 CD248 FGF2 FLT1 FLT4
11 vision/eye MP:0005391 9.28 ANPEP FGF2 FLT1 KDR PDGFRB PLG

Drugs & Therapeutics for Vascular Cancer

Drugs for Vascular Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pembrolizumab Approved Phase 2 1374853-91-4
2 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study for the Evaluation of Efficacy of Pembrolizumab (MK-3475) in Patients With Rare Tumors Recruiting NCT02721732 Phase 2

Search NIH Clinical Center for Vascular Cancer

Cochrane evidence based reviews: vascular neoplasms

Genetic Tests for Vascular Cancer

Anatomical Context for Vascular Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Vascular Cancer:

19
Blood Vessels

MalaCards organs/tissues related to Vascular Cancer:

40
Endothelial, Breast, Skin, Liver, Spleen, Bone, Heart

Publications for Vascular Cancer

Articles related to Vascular Cancer:

(show top 50) (show all 518)
# Title Authors PMID Year
1
Evaluation of anti-thrombomodulin antibody as a tumor marker for vascular neoplasms. 61 54
15491324 2004
2
Utility of the immunohistochemical detection of FLI-1 expression in round cell and vascular neoplasm using a monoclonal antibody. 54 61
15001993 2004
3
Expression of Fli-1, a nuclear transcription factor, distinguishes vascular neoplasms from potential mimics. 61 54
11474291 2001
4
Interferon alpha-2b at low doses as long-term antiangiogenic treatment of a metastatic intracranial hemangioendothelioma: a case report. 61 54
10601609 2000
5
Lack of lymphatic vascular specificity of vascular endothelial growth factor receptor 3 in 185 vascular tumors. 54 61
10590384 1999
6
The human hematopoietic progenitor cell antigen (CD34) in vascular neoplasia. 61 54
1712541 1991
7
MYC gene amplification by fluorescence in situ hybridization and MYC protein expression by immunohistochemistry in the diagnosis of cutaneous angiosarcoma: Systematic review and appropriate use criteria. 61
33128474 2021
8
Vascular neoplasms and non-neoplastic vascular lesions of the spleen. 61
32674844 2021
9
Non-hematopoietic neoplastic and pseudoneoplastic lesions of the spleen. 61
32600744 2021
10
The FDA and PLATO Investigators death lists: Call for a match. 61
33675571 2021
11
WWTR1(TAZ)-CAMTA1 reprograms endothelial cells to drive epithelioid hemangioendothelioma. 61
33766984 2021
12
Epithelioid Kaposi Sarcoma: A New Histological Variant. 61
33464749 2021
13
Small Intestinal Hemangioma: A Case Report. 61
33774648 2021
14
Risk of cause-specific death, its sex and age differences, and life expectancy in post-pancreatitis diabetes mellitus. 61
33590329 2021
15
Primary Hepatic Vascular Neoplasm in a Houston Toad (Anaxyrus houstonensis). 61
33714431 2021
16
Relationship between HER2 expression and tumor interstitial angiogenesis in primary gastric cancer and its effect on prognosis. 61
33253925 2021
17
Angiosarcomas: histology, immunohistochemistry and molecular insights with implications for differential diagnosis. 61
32885407 2021
18
Tubular laminectomy and percutaneous vertebroplasty for aggressive vertebral hemangioma. 61
33598343 2021
19
An Uncommon Presentation of Pyogenic Granuloma. 61
33564515 2021
20
Transarticular epithelioid hemangioma of the ankle-a case of a rare vascular neoplasm. 61
33420574 2021
21
Case Report on Anastomosing Haemangioma: An Unusual Vascular Tumor in Kidney. 61
33505742 2021
22
Preoperative embolisation of orbital solitary fibrous tumour. 61
33370960 2020
23
A Rare Presentation of Omental Lymphangioma Masquerading as Malignancy in an Adult Patient. 61
33324710 2020
24
Recurrent YAP1 and MAML2 Gene Rearrangements in Retiform and Composite Hemangioendothelioma. 61
32991341 2020
25
Aberrant keratin expression is common in primary hepatic malignant vascular tumors: A potential diagnostic pitfall. 61
32947230 2020
26
Single-cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma. 61
32505533 2020
27
Topical sirolimus for treatment of a solitary angiokeratoma. 61
32594609 2020
28
Multivisceral resection for locally advanced gastric cancer: A retrospective study. 61
33036727 2020
29
Primary and secondary cutaneous angiosarcoma: Distinctive clinical, pathological and molecular features. 61
32829071 2020
30
Preoperative Prediction of Axillary Lymph Node Metastasis in Breast Carcinoma Using Radiomics Features Based on the Fat-Suppressed T2 Sequence. 61
31879160 2020
31
Remodeling of Kv7.1 and Kv7.5 Expression in Vascular Tumors. 61
32825637 2020
32
Vascular malformation and their unpredictable evolution: A true challenge for physicians. 61
32921762 2020
33
An aggressive pyogenic granuloma masquerading as a vascular neoplasm. 61
32773980 2020
34
STAT3 Inhibition for Gastroenteropancreatic Neuroendocrine Tumors: Potential for a New Therapeutic Target? 61
31144189 2020
35
Primary Paraganglioma of the Facial Canal: An Evidence-Based Approach. 61
32093508 2020
36
Relationship between platelet-based models and the prognosis of patients with malignant hepatic tumors. 61
32194738 2020
37
Soft Tissue Special Issue: Perivascular and Vascular Tumors of the Head and Neck. 61
31950476 2020
38
High-throughput transcriptional profiling combined with angiogenesis antibody array analysis in an orbital venous malformation cohort. 61
31926133 2020
39
ZFP36-FOSB fusion in a haemorrhagic epithelioid and spindle cell haemangioma of bone: is there a family of FOSB-rearranged vascular neoplasms of the bone? 61
31553804 2020
40
microRNA-10 and -221 modulate differential expression of Hippo signaling pathway in human astroglial tumors. 61
32777750 2020
41
Co-existence of oral intra-muscular lipoma and lobular capillary hemangioma: A rare case report. 61
33395879 2020
42
Managing a long-recurring primary orbital hemangiopericytoma. 61
32063791 2020
43
A Rare Case of Glomus Tumor on the Mucosal Surface of Lower Lip. 61
32571080 2020
44
What is new in endothelial neoplasia? 61
31463731 2020
45
Intravascular Colonization of Kaposi Sarcoma: Expanding the Spectrum of Specific Infiltrates of B-Cell Chronic Lymphocytic Leukemia. 61
31268930 2019
46
Multifocal epithelioid hemangioma of the metacarpal bones: A case report. 61
31641394 2019
47
High frequency of GNA14, GNAQ, and GNA11 mutations in cherry hemangioma: a histopathological and molecular study of 85 cases indicating GNA14 as the most commonly mutated gene in vascular neoplasms. 61
31189994 2019
48
Congenital hemangioma of the face-Value of fetal MRI with prenatal ultrasound. 61
31695833 2019
49
Effects of sclerosing agents on head and neck hemangiomas: A systematic review. 61
31700578 2019
50
Comparison of the prognostic value of platelet-based prognostic models in patients with malignant hepatic tumors after TACE therapy. 61
31531530 2019

Variations for Vascular Cancer

Expression for Vascular Cancer

Search GEO for disease gene expression data for Vascular Cancer.

Pathways for Vascular Cancer

Pathways related to Vascular Cancer according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.26 VWF VEGFA THBS1 SERPINA3 PLG PECAM1
2
Show member pathways
12.82 VWF VEGFA THBS1 PDGFRB KDR FLT4
3 12.78 VEGFA PDGFRB IFNA2 FLT4 FGF2
4
Show member pathways
12.75 VWF VEGFA THBS1 PDGFRB KDR IFNA2
5
Show member pathways
12.7 THBS1 PLG PECAM1 KDR FGF2
6 12.69 VEGFA PDGFRB KDR FLT4 FLT1 FGF2
7
Show member pathways
12.62 VEGFA THBS1 PDGFRB KDR FLT4 FLT1
8
Show member pathways
12.38 PDGFRB KDR FLT4 FLT1
9
Show member pathways
12.35 PDGFRB KDR FLT4 FLT1 FGF2
10
Show member pathways
12.35 VEGFA KDR FLT4 FLT1 FGF2
11
Show member pathways
12.3 VEGFA KDR FLT1 FGF2
12 12.26 VEGFA PDGFRB KDR FLT4 FLT1 FGF2
13 12.25 VEGFA THBS1 KDR FGF2
14
Show member pathways
12.18 PDGFRB KDR IFNA2 FLT4 FLT1 FGF2
15
Show member pathways
12.11 VWF THBS1 PECAM1 KDR
16 12.05 PDGFRB KDR FLT4 FLT1 FGF2
17 12.04 VEGFA PDGFRB KDR FGF2
18 11.95 IFNA2 ENG CD34 ANPEP
19
Show member pathways
11.94 VEGFA PDGFRB KDR FLT1
20 11.82 FGF2 ENG CD34
21
Show member pathways
11.8 VEGFA KDR FLT4 FLT1
22
Show member pathways
11.74 PDGFRB KDR FLT4 FLT1
23 11.57 THBS1 TFE3 ENG
24 11.53 KDR FGF2 ANPEP
25 11.46 VEGFA KDR FGF2
26 11.45 VEGFA PLG KDR FGF2
27 11.34 VEGFA PDGFRB KDR
28 11.31 VEGFA KDR FLT1
29 11.26 THBS1 PLG FGF2
30 11.23 VWF THBS1 PECAM1 PDGFRB KDR FLT4
31
Show member pathways
11.2 PDGFRB KDR FLT4 FLT1
32 11.15 VEGFA FLT1 FGF2
33 11.07 VEGFA PDGFRB KDR FLT4 FLT1 FGF2
34 11 VEGFA KDR FLT1 FGF2
35 10.97 PDGFRB KDR FLT4 FLT1 FGF2
36
Show member pathways
10.66 VEGFA KDR FLT4 FLT1

GO Terms for Vascular Cancer

Cellular components related to Vascular Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.9 VWF VEGFA THBS1 SERPINA3 PLG KDR
2 external side of plasma membrane GO:0009897 9.8 THBS1 ENG CD34 CD248 ANPEP
3 cell surface GO:0009986 9.8 VEGFA THBS1 PLG PDGFRB ENG CD34
4 collagen-containing extracellular matrix GO:0062023 9.77 VWF THBS1 SERPINA3 PLG IFNA2
5 extracellular space GO:0005615 9.7 VWF VEGFA THBS1 SERPINA3 PLG PECAM1
6 receptor complex GO:0043235 9.65 PDGFRB KDR FLT4 FLT1 ENG
7 platelet alpha granule lumen GO:0031093 9.02 VWF VEGFA THBS1 SERPINA3 PLG

Biological processes related to Vascular Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 10.23 VEGFA PDGFRB KDR FLT4 FLT1 FGF2
2 negative regulation of apoptotic process GO:0043066 10.11 VEGFA THBS1 PDGFRB KDR FLT4
3 extracellular matrix organization GO:0030198 10.03 VWF THBS1 PECAM1 KDR FGF2
4 negative regulation of gene expression GO:0010629 10.03 VEGFA KDR IFNA2 FGF2 ENG CD34
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.02 VEGFA PDGFRB KDR FLT4 FGF2
6 cell migration GO:0016477 10.01 THBS1 PDGFRB KDR FLT1 ENG CD248
7 positive regulation of protein kinase B signaling GO:0051897 10 VEGFA THBS1 PDGFRB FGF2 ENG
8 protein autophosphorylation GO:0046777 9.98 PDGFRB KDR FLT4 FLT1
9 positive regulation of cell migration GO:0030335 9.97 VEGFA THBS1 PECAM1 PDGFRB KDR FLT1
10 positive regulation of cell proliferation GO:0008284 9.97 VEGFA THBS1 PDGFRB KDR FLT4 FLT1
11 peptidyl-tyrosine phosphorylation GO:0018108 9.96 PDGFRB KDR FLT4 FLT1
12 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.96 PDGFRB KDR FLT4 FLT1
13 positive regulation of kinase activity GO:0033674 9.91 PDGFRB KDR FLT4 FLT1
14 positive regulation of endothelial cell proliferation GO:0001938 9.91 VEGFA KDR FLT4 FGF2
15 positive regulation of MAPK cascade GO:0043410 9.91 VEGFA KDR FLT4 FLT1 FGF2
16 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.88 VEGFA KDR FLT4 FLT1
17 positive regulation of protein phosphorylation GO:0001934 9.88 VEGFA PECAM1 KDR FLT4 FGF2 ENG
18 vasculogenesis GO:0001570 9.87 VEGFA KDR ENG
19 positive regulation of MAP kinase activity GO:0043406 9.87 VEGFA PDGFRB FLT1 FGF2
20 hematopoietic progenitor cell differentiation GO:0002244 9.86 KDR FLT4 FLT1
21 hemostasis GO:0007599 9.86 VWF PLG FLI1
22 positive regulation of blood vessel endothelial cell migration GO:0043536 9.85 VEGFA THBS1 KDR FGF2
23 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.83 VEGFA KDR FGF2
24 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.83 VEGFA PDGFRB KDR FLT1 FGF2
25 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.82 PDGFRB FLT1 FGF2
26 positive regulation of phosphorylation GO:0042327 9.81 VEGFA THBS1 IFNA2
27 branching involved in blood vessel morphogenesis GO:0001569 9.81 VEGFA KDR ENG
28 cell migration involved in sprouting angiogenesis GO:0002042 9.79 VEGFA KDR FGF2
29 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.78 VEGFA KDR FLT4 FLT1
30 positive regulation of DNA biosynthetic process GO:2000573 9.77 VEGFA PDGFRB FGF2
31 sprouting angiogenesis GO:0002040 9.76 VEGFA THBS1 FLT4 ENG
32 positive regulation of phospholipase C activity GO:0010863 9.75 PDGFRB FLT1 FGF2
33 positive regulation of endothelial cell migration GO:0010595 9.72 VEGFA THBS1 KDR FLT4 FGF2
34 positive regulation of vasculogenesis GO:2001214 9.71 KDR CD34
35 positive regulation of positive chemotaxis GO:0050927 9.71 VEGFA KDR
36 negative regulation of cell-cell adhesion mediated by cadherin GO:2000048 9.71 VEGFA PLG
37 positive regulation of protein kinase C signaling GO:0090037 9.7 VEGFA FLT4
38 positive regulation of transforming growth factor beta production GO:0071636 9.7 THBS1 CD34
39 negative regulation of fibrinolysis GO:0051918 9.7 THBS1 PLG
40 stem cell proliferation GO:0072089 9.7 FGF2 CD34
41 vascular wound healing GO:0061042 9.7 VEGFA KDR CD34
42 angiogenesis GO:0001525 9.7 VEGFA KDR FLT4 FLT1 FGF2 ENG
43 paracrine signaling GO:0038001 9.68 FGF2 CD34
44 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.68 VEGFA KDR
45 vascular endothelial growth factor receptor-2 signaling pathway GO:0036324 9.67 VEGFA KDR
46 endothelium development GO:0003158 9.67 KDR CD34
47 positive regulation of epithelial tube formation GO:1905278 9.67 VEGFA FGF2
48 glomerular endothelium development GO:0072011 9.65 PECAM1 CD34
49 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 9.65 VEGFA PDGFRB
50 vascular endothelial growth factor signaling pathway GO:0038084 9.56 VEGFA KDR FLT4 FLT1

Molecular functions related to Vascular Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.41 VWF VEGFA THBS1 TFE3 SERPINA3 PLG
2 integrin binding GO:0005178 9.67 VWF THBS1 KDR FGF2
3 protein tyrosine kinase activity GO:0004713 9.62 PDGFRB KDR FLT4 FLT1
4 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.46 PDGFRB KDR FLT4 FLT1
5 extracellular matrix binding GO:0050840 9.43 VEGFA THBS1 CD248
6 vascular endothelial growth factor binding GO:0038085 9.4 PDGFRB KDR
7 growth factor binding GO:0019838 9.26 PDGFRB KDR FLT4 FLT1
8 vascular endothelial growth factor-activated receptor activity GO:0005021 8.8 KDR FLT4 FLT1

Sources for Vascular Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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