MCID: VSC006
MIFTS: 47

Vascular Cancer

Categories: Cancer diseases, Nephrological diseases, Cardiovascular diseases, Blood diseases

Aliases & Classifications for Vascular Cancer

MalaCards integrated aliases for Vascular Cancer:

Name: Vascular Cancer 12 15
Malignant Vascular Neoplasm 12 73
Renal Vein Leiomyosarcoma 12 73
Blood Vessel Tumors 12 55
Vascular Neoplasms 44 73
Malignant Tumor of Pulmonary Artery 12
Pulmonary Artery Malignant Neoplasm 12
Malignant Neoplasm of Great Vessels 73
Malignant Tumor of Pulmonary Vein 12
Pulmonary Vein Malignant Neoplasm 12
Leiomyosarcoma of the Renal Vein 12
Blood Vessel Tumour Disorder 12
Malignant Great Vessel Tumor 12
Neoplasms, Vascular Tissue 73
Malignant Vascular Tumor 12
Neoplasm of Great Vessel 12
Vascular Tissue Neoplasm 12
Haemangiomatous Tumour 12
Blood Vessel Neoplasm 12
Blood Vessel Cancer 73
Blood Vessel Tumor 12
Vascular Tumors 12

Classifications:



Summaries for Vascular Cancer

Disease Ontology : 12 A cardiovascular cancer that is located in blood vessels.

MalaCards based summary : Vascular Cancer, also known as malignant vascular neoplasm, is related to hemangioendothelioma and kaposiform hemangioendothelioma. An important gene associated with Vascular Cancer is FLT4 (Fms Related Tyrosine Kinase 4), and among its related pathways/superpathways are TGF-Beta Pathway and Akt Signaling. The drugs Cyclophosphamide and Propranolol have been mentioned in the context of this disorder. Affiliated tissues include blood vessels and endothelial, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Vascular Cancer

Diseases related to Vascular Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 hemangioendothelioma 32.1 CAMTA1 FLI1 FLT4 KDR
2 kaposiform hemangioendothelioma 31.8 FLI1 FLT4 KDR VWF
3 breast angiosarcoma 31.5 HBA1 KIT
4 glomeruloid hemangioma 30.8 ENG FLT1 HBA1 VEGFA
5 angiosarcoma 29.9 FLI1 FLT1 FLT4 KDR KIT VEGFA
6 renal cell carcinoma, nonpapillary 27.8 FGF2 FLT1 FLT4 KDR KIT PDGFRB
7 spindle cell hemangioma 11.2
8 hemifacial spasm 10.8 FLT4 VEGFA
9 carotid body cancer 10.7
10 hemangioma, capillary infantile 10.7 FLT4 KDR
11 chronic myocardial ischemia 10.6 FGF2 VEGFA
12 infiltrating angiolipoma 10.5 VEGFA VWF
13 histiocytoid hemangioma 10.5 CAMTA1 HBA1
14 critical limb ischemia 10.5 VEGFA VWF
15 microcystic meningioma 10.5 FLT1 VEGFA
16 kuhnt-junius degeneration 10.5 KDR VEGFA
17 pediatric angiosarcoma 10.5 HBA1 VEGFA
18 bone squamous cell carcinoma 10.5 ENG KDR
19 hobnail hemangioma 10.5 FLT4 HBA1
20 lipodermatosclerosis 10.5 FLT1 VEGFA
21 conventional angiosarcoma 10.5 CAMTA1 HBA1
22 hypoglycemic coma 10.5 HBA1 VEGFA
23 radiation proctitis 10.4 FGF2 KDR VEGFA
24 angiokeratoma circumscriptum 10.4 FLT1 KDR VEGFA
25 acute hemorrhagic leukoencephalitis 10.4 FLT1 KDR VEGFA
26 hydrocele 10.4 FLT4 VEGFA
27 placental insufficiency 10.4 FLT1 KDR VEGFA
28 pulmonary vein stenosis 10.4 KDR KIT
29 exudative vitreoretinopathy 1 10.4 FLT1 KDR VEGFA
30 microvascular complications of diabetes 1 10.3 FGF2 FLT1 VEGFA
31 cancer-associated retinopathy 10.3 FLT1 VEGFA
32 twin-to-twin transfusion syndrome 10.3 ENG FLT1
33 desmoid tumor 10.3 KIT PDGFRB
34 hypereosinophilic syndrome, idiopathic 10.3 KIT PDGFRB
35 spleen angiosarcoma 10.3 HBA1 VWF
36 pilocytic astrocytoma 10.3 FGF2 KDR PDGFRB
37 capillary hemangioma 10.2 HBA1 KDR VEGFA
38 skin hemangioma 10.2 HBA1 KDR VEGFA
39 epithelioid hemangioendothelioma 10.2 CAMTA1 FLT1 KDR VEGFA
40 interstitial emphysema 10.2 FLT1 FLT4 HBA1
41 hemangioma 10.2 FGF2 FLT4 KDR VEGFA
42 breast carcinoma in situ 10.1 FLT1 FLT4 KDR VEGFA
43 posterior uveal melanoma 10.1 THBS1 VEGFA
44 heart sarcoma 10.1 KIT PDGFRB
45 8p11 myeloproliferative syndrome 10.1 KDR KIT PDGFRB
46 fibrosarcoma of bone 10.1 KDR KIT PDGFRB
47 chronic eosinophilic leukemia 10.1 KIT PDGFRB
48 microvascular complications of diabetes 5 10.0 FGF2 FLT1 KDR VEGFA
49 mast-cell sarcoma 10.0 ANPEP KIT
50 angiomyoma 10.0 HBA1 KIT

Graphical network of the top 20 diseases related to Vascular Cancer:



Diseases related to Vascular Cancer

Symptoms & Phenotypes for Vascular Cancer

MGI Mouse Phenotypes related to Vascular Cancer:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.35 ENG FLT1 FGF2 ANPEP FLI1 KDR
2 hematopoietic system MP:0005397 10.25 ENG FLT1 FGF2 ANPEP FLI1 KDR
3 growth/size/body region MP:0005378 10.22 CAMTA1 FLI1 ENG FLT1 FLT4 KIT
4 cellular MP:0005384 10.21 FLI1 FGF2 KIT KDR FLT1 VWF
5 homeostasis/metabolism MP:0005376 10.19 ENG FLT1 FGF2 FLT4 KIT KDR
6 immune system MP:0005387 10.18 FLT1 ANPEP FLI1 KDR PDGFRB KIT
7 mortality/aging MP:0010768 10.18 ENG FLT1 FGF2 CAMTA1 FLI1 KDR
8 embryo MP:0005380 10.14 FLI1 ENG FLT1 KDR PDGFRB FLT4
9 digestive/alimentary MP:0005381 10.09 ENG KIT PDGFRB FLT4 VWF THBS1
10 muscle MP:0005369 10.07 ENG FLT1 FGF2 FLI1 KDR PDGFRB
11 integument MP:0010771 10.06 ENG ANPEP KDR PDGFRB FLT4 KIT
12 nervous system MP:0003631 9.96 FLI1 ENG FLT1 FGF2 CAMTA1 KDR
13 liver/biliary system MP:0005370 9.91 FLI1 FLT4 KIT KDR THBS1 VEGFA
14 neoplasm MP:0002006 9.8 CAMTA1 FLI1 FGF2 KIT THBS1 VEGFA
15 normal MP:0002873 9.76 ENG FLT1 CAMTA1 KDR PDGFRB FLT4
16 reproductive system MP:0005389 9.61 FLT1 FGF2 ANPEP CAMTA1 PDGFRB KIT
17 vision/eye MP:0005391 9.23 FLT1 FGF2 ANPEP KDR PDGFRB KIT

Drugs & Therapeutics for Vascular Cancer

Drugs for Vascular Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
2
Propranolol Approved, Investigational Phase 1, Phase 2 525-66-6 4946
3 Adrenergic Agents Phase 1, Phase 2
4 Adrenergic Antagonists Phase 1, Phase 2
5 Adrenergic beta-Antagonists Phase 1, Phase 2
6 Anti-Arrhythmia Agents Phase 1, Phase 2
7 Antihypertensive Agents Phase 1, Phase 2
8 Neurotransmitter Agents Phase 1, Phase 2
9 Vasodilator Agents Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dose-Finding of Propranolol in Combination With Metronomic Fixed Oral Cyclophosphamide Based on Bivariate Efficacy-tolerability Outcome in Patients With Locally Advanced or Metastatic Angiosarcoma: A Collaborative and Innovative Phase I-II Sequential Tria Not yet recruiting NCT02732678 Phase 1, Phase 2 PROPRANOLOL

Search NIH Clinical Center for Vascular Cancer

Cochrane evidence based reviews: vascular neoplasms

Genetic Tests for Vascular Cancer

Anatomical Context for Vascular Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Vascular Cancer:

19
Blood Vessels

MalaCards organs/tissues related to Vascular Cancer:

41
Endothelial

Publications for Vascular Cancer

Articles related to Vascular Cancer:

# Title Authors Year
1
Research gives hope to patients with rare vascular cancer. Cleveland Clinic researchers suggest that their work could lead to breakthrough in treating other cancers. ( 22272406 )
2011
2
Cutaneous reactive angiomatosis occurring in erythema ab igne can cause atypia in endothelial cells: potential mimic of malignant vascular neoplasm. ( 15982219 )
2005
3
New strategies in anti-vascular cancer therapy. ( 10469169 )
1999
4
Anti-vascular cancer therapy: is it a dream or reality? ( 1720044 )
1991

Variations for Vascular Cancer

Expression for Vascular Cancer

Search GEO for disease gene expression data for Vascular Cancer.

Pathways for Vascular Cancer

Pathways related to Vascular Cancer according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.42 FGF2 FLT1 FLT4 KDR KIT PDGFRB
2
Show member pathways
13.31 FGF2 FLT1 FLT4 KDR KIT PDGFRB
3
Show member pathways
13.23 FGF2 FLT1 FLT4 KDR KIT PDGFRB
4
Show member pathways
13.21 FGF2 FLT1 FLT4 KDR KIT PDGFRB
5
Show member pathways
13.18 FGF2 FLT1 FLT4 KDR KIT PDGFRB
6
Show member pathways
12.98 FGF2 FLT1 FLT4 KDR KIT PDGFRB
7
Show member pathways
12.96 FGF2 FLT1 FLT4 KDR KIT PDGFRB
8
Show member pathways
12.88 FLT1 FLT4 KDR KIT PDGFRB
9
Show member pathways
12.81 FLT1 FLT4 KDR PDGFRB THBS1 VEGFA
10 12.77 FGF2 FLT4 KIT PDGFRB VEGFA
11 12.69 FGF2 FLT1 FLT4 KDR KIT PDGFRB
12
Show member pathways
12.66 FGF2 KDR PDGFRB VEGFA
13
Show member pathways
12.64 FGF2 FLT1 FLT4 KDR KIT PDGFRB
14
Show member pathways
12.6 FGF2 FLT1 FLT4 KDR
15
Show member pathways
12.5 FGF2 FLT1 FLT4 KDR KIT PDGFRB
16
Show member pathways
12.43 FLT1 FLT4 KDR PDGFRB
17
Show member pathways
12.38 FLT1 FLT4 KDR PDGFRB
18
Show member pathways
12.34 FLT1 FLT4 KDR VEGFA
19
Show member pathways
12.33 FGF2 FLT1 FLT4 KDR VEGFA
20 12.24 FGF2 KDR THBS1 VEGFA
21
Show member pathways
12.18 FGF2 FLT1 KDR VEGFA
22 12.1 FLT1 FLT4 KDR PDGFRB
23
Show member pathways
12.04 KDR THBS1 VWF
24
Show member pathways
12.01 FLT1 FLT4 KDR PDGFRB
25 12 FGF2 KDR PDGFRB VEGFA
26
Show member pathways
11.99 FGF2 FLT1 FLT4 KDR
27 11.97 FGF2 FLT1 FLT4 KDR KIT PDGFRB
28
Show member pathways
11.93 FLT1 KDR PDGFRB VEGFA
29 11.92 ANPEP ENG KIT
30
Show member pathways
11.8 FLT1 FLT4 KDR VEGFA
31
Show member pathways
11.75 FLT1 FLT4 KDR KIT PDGFRB
32
Show member pathways
11.59 FLT1 FLT4 KDR KIT PDGFRB
33 11.54 ANPEP FGF2 KDR KIT
34 11.5 FGF2 KDR VEGFA
35 11.49 FGF2 KIT VEGFA
36 11.46 FGF2 KDR VEGFA
37
Show member pathways
11.4 KDR PDGFRB VEGFA
38 11.29 FLT1 KDR VEGFA
39 11.17 ENG FGF2 FLT1 FLT4 KDR PDGFRB
40 11.15 FGF2 FLT1 VEGFA
41 11.14 FGF2 FLT1 KDR VEGFA
42 11.06 FGF2 FLT1 FLT4 KDR PDGFRB VEGFA
43
Show member pathways
10.87 FLT1 FLT4 KDR VEGFA

GO Terms for Vascular Cancer

Cellular components related to Vascular Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 FGF2 FLT1 FLT4 HBA1 KDR THBS1
2 cell surface GO:0009986 9.77 ENG KIT PDGFRB THBS1 VEGFA
3 external side of plasma membrane GO:0009897 9.62 ANPEP ENG KIT THBS1
4 extracellular space GO:0005615 9.56 ANPEP ENG FGF2 FLT1 HBA1 KIT
5 platelet alpha granule GO:0031091 9.4 THBS1 VWF
6 platelet alpha granule lumen GO:0031093 9.33 THBS1 VEGFA VWF
7 receptor complex GO:0043235 9.1 ENG FLT1 FLT4 KDR KIT PDGFRB

Biological processes related to Vascular Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of MAPK cascade GO:0043410 9.99 FLT1 FLT4 KDR KIT PDGFRB
2 extracellular matrix organization GO:0030198 9.97 FGF2 KDR THBS1 VWF
3 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.96 FLT1 FLT4 KDR KIT PDGFRB
4 positive regulation of protein phosphorylation GO:0001934 9.95 ENG FLT4 KDR VEGFA
5 negative regulation of signal transduction GO:0009968 9.95 FLT1 FLT4 KDR KIT PDGFRB
6 positive regulation of cell migration GO:0030335 9.95 FLT1 KDR KIT PDGFRB THBS1 VEGFA
7 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.93 FLT1 FLT4 KDR VEGFA
8 positive regulation of endothelial cell proliferation GO:0001938 9.92 FGF2 FLT4 KDR VEGFA
9 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.92 FLT1 KDR KIT PDGFRB
10 chemotaxis GO:0006935 9.89 FGF2 FLT1 PDGFRB
11 regulation of cell shape GO:0008360 9.89 KDR KIT VEGFA
12 positive regulation of endothelial cell migration GO:0010595 9.88 FLT4 KDR THBS1 VEGFA
13 positive regulation of blood vessel endothelial cell migration GO:0043536 9.88 FGF2 KDR THBS1 VEGFA
14 peptidyl-tyrosine phosphorylation GO:0018108 9.88 FGF2 FLT1 FLT4 KDR KIT PDGFRB
15 platelet degranulation GO:0002576 9.87 THBS1 VEGFA VWF
16 activation of MAPK activity GO:0000187 9.87 FGF2 KIT THBS1
17 phosphatidylinositol phosphorylation GO:0046854 9.86 FGF2 KIT PDGFRB
18 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.83 FGF2 FLT1 KIT PDGFRB
19 positive regulation of kinase activity GO:0033674 9.83 FLT1 FLT4 KDR KIT PDGFRB
20 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.82 FGF2 KDR VEGFA
21 cell migration involved in sprouting angiogenesis GO:0002042 9.81 FGF2 KDR VEGFA
22 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.81 FLT1 FLT4 KDR VEGFA
23 sprouting angiogenesis GO:0002040 9.8 ENG FLT1 FLT4 THBS1
24 vascular endothelial growth factor signaling pathway GO:0038084 9.78 FLT1 FLT4 KDR
25 positive regulation of MAP kinase activity GO:0043406 9.77 FGF2 FLT1 KIT PDGFRB VEGFA
26 positive regulation of cell proliferation GO:0008284 9.76 FGF2 FLT1 FLT4 KDR KIT PDGFRB
27 positive regulation of angiogenesis GO:0045766 9.73 ENG FGF2 FLT1 KDR THBS1 VEGFA
28 blood vessel morphogenesis GO:0048514 9.72 FLT1 FLT4
29 vasculogenesis GO:0001570 9.72 ENG FLT1 FLT4 KDR VEGFA
30 positive regulation of sprouting angiogenesis GO:1903672 9.71 FGF2 VEGFA
31 positive regulation of collagen biosynthetic process GO:0032967 9.71 ENG PDGFRB
32 positive regulation of focal adhesion assembly GO:0051894 9.71 KDR VEGFA
33 artery morphogenesis GO:0048844 9.7 ENG VEGFA
34 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.7 FLT1 VEGFA
35 embryonic hemopoiesis GO:0035162 9.69 KDR KIT
36 embryonic morphogenesis GO:0048598 9.69 FGF2 FLT1
37 megakaryocyte development GO:0035855 9.69 FLI1 KIT
38 positive regulation of positive chemotaxis GO:0050927 9.68 KDR VEGFA
39 positive regulation of chemotaxis GO:0050921 9.68 PDGFRB THBS1
40 positive regulation of protein kinase C signaling GO:0090037 9.67 FLT4 VEGFA
41 regulation of cGMP metabolic process GO:0030823 9.66 THBS1 VEGFA
42 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.66 KDR VEGFA
43 positive regulation of vascular smooth muscle cell differentiation GO:1905065 9.65 ENG KIT
44 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 9.65 PDGFRB VEGFA
45 angiogenesis GO:0001525 9.5 ANPEP ENG FGF2 FLT1 FLT4 KDR
46 positive regulation of phospholipase C activity GO:0010863 8.92 FGF2 FLT1 KIT PDGFRB
47 multicellular organism development GO:0007275 10.24 ANPEP FGF2 FLT1 FLT4 KDR KIT
48 negative regulation of apoptotic process GO:0043066 10.11 FLT1 FLT4 KDR KIT PDGFRB THBS1
49 cell differentiation GO:0030154 10.11 ANPEP FGF2 FLI1 FLT1 FLT4 KDR
50 phosphorylation GO:0016310 10.08 FLT1 FLT4 KDR KIT PDGFRB

Molecular functions related to Vascular Cancer according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.97 ENG FLT4 KIT VEGFA VWF
2 kinase activity GO:0016301 9.92 FLT1 FLT4 KDR KIT PDGFRB
3 protein kinase activity GO:0004672 9.89 FLT1 FLT4 KDR KIT PDGFRB
4 transmembrane signaling receptor activity GO:0004888 9.88 ENG FLT1 FLT4 KDR KIT PDGFRB
5 heparin binding GO:0008201 9.76 FGF2 THBS1 VEGFA
6 integrin binding GO:0005178 9.73 FGF2 KDR THBS1 VWF
7 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.72 FGF2 KIT PDGFRB
8 MAP kinase kinase kinase activity GO:0004709 9.72 FLT1 FLT4 KDR KIT PDGFRB
9 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.65 FGF2 KIT PDGFRB
10 mitogen-activated protein kinase kinase binding GO:0031434 9.65 FLT1 FLT4 KDR KIT PDGFRB
11 protein tyrosine kinase activity GO:0004713 9.63 FGF2 FLT1 FLT4 KDR KIT PDGFRB
12 fibronectin binding GO:0001968 9.59 THBS1 VEGFA
13 transforming growth factor beta binding GO:0050431 9.56 ENG THBS1
14 platelet-derived growth factor receptor binding GO:0005161 9.54 PDGFRB VEGFA
15 vascular endothelial growth factor-activated receptor activity GO:0005021 9.54 FLT1 FLT4 KDR
16 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.51 KDR KIT
17 vascular endothelial growth factor binding GO:0038085 9.46 KDR PDGFRB
18 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.35 FLT1 FLT4 KDR KIT PDGFRB
19 growth factor binding GO:0019838 9.02 FLT1 FLT4 KDR KIT PDGFRB
20 protein binding GO:0005515 10.39 CAMTA1 ENG FGF2 FLI1 FLT1 FLT4

Sources for Vascular Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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