MCID: VSC009
MIFTS: 21

Vascular Skin Disease

Categories: Cardiovascular diseases, Rare diseases, Skin diseases

Aliases & Classifications for Vascular Skin Disease

MalaCards integrated aliases for Vascular Skin Disease:

Name: Vascular Skin Disease 12 15
Skin Diseases, Vascular 43 71
Skin Vascular Disease 58

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:9540
ICD9CM 34 709.1
MeSH 43 D017445
NCIt 49 C35254
SNOMED-CT 67 11263005
MESH via Orphanet 44 D017445
UMLS via Orphanet 72 C0162819
Orphanet 58 ORPHA79379
UMLS 71 C0162819

Summaries for Vascular Skin Disease

MalaCards based summary : Vascular Skin Disease, also known as skin diseases, vascular, is related to skin disease and dermatitis, atopic, and has symptoms including pruritus and exanthema. An important gene associated with Vascular Skin Disease is PTRH1 (Peptidyl-TRNA Hydrolase 1 Homolog). The drugs Histamine and Desloratadine have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotype is pigmentation.

Related Diseases for Vascular Skin Disease

Diseases related to Vascular Skin Disease via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 skin disease 9.9
2 dermatitis, atopic 9.7
3 telangiectasis 9.7
4 vascular disease 9.7
5 contact dermatitis 9.7
6 liver disease 9.7
7 erythema infectiosum 9.7
8 rosacea 9.7

Graphical network of the top 20 diseases related to Vascular Skin Disease:



Diseases related to Vascular Skin Disease

Symptoms & Phenotypes for Vascular Skin Disease

UMLS symptoms related to Vascular Skin Disease:


pruritus, exanthema

MGI Mouse Phenotypes related to Vascular Skin Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 pigmentation MP:0001186 8.8 FUCA1 STING1 TFEC

Drugs & Therapeutics for Vascular Skin Disease

Drugs for Vascular Skin Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 3 51-45-6 774
2
Desloratadine Approved, Investigational Phase 3 100643-71-8 124087
3
Levocetirizine Approved Phase 3 130018-77-8 1549000
4 Cholinergic Agents Phase 3
5 Histamine Antagonists Phase 3
6 Histamine H1 Antagonists, Non-Sedating Phase 3
7 Histamine H1 Antagonists Phase 3
8
Histamine Phosphate Phase 3 51-74-1 65513
9 Cholinergic Antagonists Phase 3
10 Neurotransmitter Agents Phase 3
11
Icatibant Approved, Investigational Phase 1 138614-30-9, 130308-48-4 71364
12
Bradykinin Investigational Phase 1 58-82-2 439201
13 Analgesics, Non-Narcotic Phase 1
14 Kininogens Phase 1
15 Adrenergic beta-Antagonists Phase 1
16 Immunologic Factors Phase 1
17 Adrenergic Agents Phase 1
18 Analgesics Phase 1
19 Complement System Proteins Phase 1
20 Adrenergic Antagonists Phase 1
21 Immunosuppressive Agents Phase 1
22 Anti-Inflammatory Agents Phase 1
23 Bradykinin Receptor Antagonists Phase 1
24 Antirheumatic Agents Phase 1
25 Anti-Inflammatory Agents, Non-Steroidal Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase III Multicentre, Parallel-group, Randomized, Placebo-controlled, Double-blind Clinical Trial to Study the Efficacy and Safety of MK-4117 in Japanese Subjects With Chronic Urticaria. Completed NCT01916967 Phase 3 Desloratadine;Placebo
2 Double-blind, Randomised, Placebo-controlled, Phase III Study Comparing the Efficacy and Safety of Bilastine 20 mg Once Daily and Levocetirizine 5 mg for the Treatment of Chronic Idiopathic Urticaria Completed NCT00421109 Phase 3 Bilastine;Levocetirizine;Placebo
3 An Open-label, Single-arm Study to Assess the Pharmacokinetics, Safety, and Tolerability of a Single Subcutaneous Dose of Icatibant in Healthy Japanese Volunteers Completed NCT02045264 Phase 1 Icatibant (30 mg)

Search NIH Clinical Center for Vascular Skin Disease

Cochrane evidence based reviews: skin diseases, vascular

Genetic Tests for Vascular Skin Disease

Anatomical Context for Vascular Skin Disease

MalaCards organs/tissues related to Vascular Skin Disease:

40
Skin

Publications for Vascular Skin Disease

Articles related to Vascular Skin Disease:

# Title Authors PMID Year
1
Angiogenesis, lymphangiogenesis and atopic dermatitis. 61
22433371 2012

Variations for Vascular Skin Disease

Expression for Vascular Skin Disease

Search GEO for disease gene expression data for Vascular Skin Disease.

Pathways for Vascular Skin Disease

GO Terms for Vascular Skin Disease

Sources for Vascular Skin Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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