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MCID: VSC011
MIFTS: 65

Vasculitis

Categories: Rare diseases, Cardiovascular diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Vasculitis

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MalaCards integrated aliases for Vasculitis:

Name: Vasculitis 12 76 53 29 55 6 43 44 15 63 73
Autoimmune Vasculitis 53 73
Angiitis 12 53
Vasculitis, Autoimmune 53

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:865
MeSH 44 D014657
NCIt 50 C26912
Sources

Summaries for Vasculitis

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NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 52759Disease definitionVasculitis represents a clinically heterogenous group of diseases of multifactorial etiology characterized by inflammation of either large-sized vessels (large-vessel vasculitis, e.g. Giant-cell arteritis and Takayasu arteritis; see these terms), medium-sized vessels (medium-vessel vasculitis e.g. polyarteritis nodosa and Kawasaki disease; see these terms), or small-sized vessels (small-vessel vasculitis, e.g. granulomatosis with polyangiitis, microscopic polyangiitis, immunoglobulin A vasculitis, and cutaneous leukocytoclastic angiitis; see these terms). Vasculitis occurs at any age, may be acute or chronic, and manifests with general symptoms such as fever, weight loss and fatigue, as well as more specific clinical signs depending on the type of vessels and organs affected. The degree of severity is variable, ranging from life or sight threatening disease (e.g. Behçet disease, see this term) to relatively minor skin disease.Visit the Orphanet disease page for more resources.

MalaCards based summary : Vasculitis, also known as autoimmune vasculitis, is related to lymphocytic vasculitis and anca-associated vasculitis, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Vasculitis is PRTN3 (Proteinase 3), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Innate Immune System. The drugs alemtuzumab and Menthol have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, skin and lung, and related phenotypes are hematopoietic system and cellular

Disease Ontology : 12 A vascular disease that is characterized by inflammation of the blood vessels.

MedlinePlus : 43 Vasculitis is an inflammation of the blood vessels. It happens when the body's immune system attacks the blood vessel by mistake. It can happen because of an infection, a medicine, or another disease. The cause is often unknown. Vasculitis can affect arteries, veins and capillaries. Arteries are vessels that carry blood from the heart to the body's organs. Veins are the vessels that carry blood back to the heart. Capillaries are tiny blood vessels that connect the small arteries and veins. When a blood vessel becomes inflamed, it can Narrow, making it more difficult for blood to get through Close off completely so that blood can't get through Stretch and weaken so much that it bulges. The bulge is called an aneurysm. If it bursts, it can cause dangerous bleeding inside the body. Symptoms of vasculitis can vary, but usually include fever, swelling and a general sense of feeling ill. The main goal of treatment is to stop the inflammation. Steroids and other medicines to stop inflammation are often helpful. NIH: National Heart, Lung, and Blood Institute

PubMed Health : 63 About vasculitis: Vasculitis (vas-kyu-LI-tis) is a condition that involves inflammation in the blood vessels. The condition occurs if your immune system attacks your blood vessels by mistake. This may happen as the result of an infection, a medicine, or another disease or condition.“Inflammation” refers to the body’s response to injury, including injury to the blood vessels. Inflammation may involve pain, redness, warmth, swelling, and loss of function in the affected tissues.In vasculitis, inflammation can lead to serious problems. Complications depend on which blood vessels, organs, or other body systems are affected.

Wikipedia : 76 Vasculitis is a group of disorders that destroy blood vessels by inflammation. Both arteries and veins... more...

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Related Diseases for Vasculitis

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Diseases related to Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 839)
# Related Disease Score Top Affiliating Genes
1 lymphocytic vasculitis 34.8 ICAM1 SELE VCAM1
2 anca-associated vasculitis 34.5 MPO PRTN3 SERPINA1 TNF
3 rheumatoid vasculitis 34.3 CX3CL1 ICAM1 SELE TNF VCAM1
4 central nervous system vasculitis 33.3 CD40LG CRP TNF
5 microscopic polyangiitis 33.3 MPO TNF
6 kawasaki disease 33.0 CRP ELANE SELE TNF
7 livedoid vasculopathy 33.0 APOH CD40LG
8 alpha-1-antitrypsin deficiency 32.8 BPI ELANE SERPINA1
9 hypersensitivity vasculitis 32.2 CD40LG CD79A CRP MEFV MPO
10 temporal arteritis 32.1 APOH CD40LG CRP
11 churg-strauss syndrome 31.9 CD40LG MPO PRTN3 THBD TNF
12 polyarteritis nodosa 31.8 APOH CRP MEFV MPO PRTN3 SELE
13 cryoglobulinemia 31.3 CD40LG CD79A TNFSF13B
14 immune-complex glomerulonephritis 30.9 ICAM1 MPO VCAM1
15 arthus reaction 30.8 ELANE ICAM1 TNF
16 crescentic glomerulonephritis 30.8 BPI CTSG ICAM1 MPO VCAM1
17 chorioamnionitis 30.7 CRP ELANE TNF
18 cytomegalovirus infection 30.5 ICAM1 SELE TNF VCAM1
19 endocarditis 30.5 APOH CRP TNF VCAM1
20 respiratory failure 30.5 CRP ELANE SERPINA1 TNF
21 infective endocarditis 30.4 APOH CRP TNF
22 membranous nephropathy 30.3 CD79A MPO TNF
23 erysipelas 30.3 ELANE MEFV TNF
24 appendicitis 30.3 CRP MPO TNF
25 posterior scleritis 30.3 PRTN3 TNF
26 critical limb ischemia 30.3 SELE TNF VWF
27 familial mediterranean fever 30.2 CRP MEFV TNF
28 spotted fever 30.2 THBD TNF VWF
29 pericarditis 30.1 CRP MEFV TNF
30 thrombosis 30.1 APOH THBD VWF
31 adult-onset still's disease 30.1 CRP MEFV TNF
32 bronchiectasis 30.1 BPI CTSG ELANE MPO SERPINA1
33 mononeuritis multiplex 30.0 CD40LG CRP MPO
34 wegener granulomatosis 30.0 BPI CRP CTSG ELANE MPO PRTN3
35 rapidly progressive glomerulonephritis 30.0 CD79A CRP ELANE ICAM1 MPO PRTN3
36 erythema multiforme 29.9 CD79A ICAM1 TNF
37 stroke, ischemic 29.9 APOH CRP THBD VWF
38 diabetic angiopathy 29.9 SELE THBD VWF
39 venous insufficiency 29.9 CRP ICAM1 VCAM1 VWF
40 reactive arthritis 29.9 BPI CD79A CRP TNF
41 meningitis 29.9 CD40LG CRP TNF
42 relapsing fever 29.8 CRP MEFV TNF
43 thrombotic thrombocytopenic purpura 29.7 APOH SELE THBD VWF
44 collagen disease 29.7 APOH THBD VWF
45 arteriosclerosis 29.7 CRP ICAM1 SELE THBD VCAM1
46 peripheral vascular disease 29.7 CRP SELE THBD VCAM1 VWF
47 sjogren syndrome 29.6 APOH CD79A TNFSF13B
48 thrombophilia due to thrombin defect 29.6 APOH THBD VWF
49 purpura 29.6 APOH CD40LG CD79A CRP THBD TNF
50 pulmonary emphysema 29.6 ELANE SERPINA1 SERPINB1

Graphical network of the top 20 diseases related to Vasculitis:



Diseases related to Vasculitis
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Symptoms & Phenotypes for Vasculitis

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UMLS symptoms related to Vasculitis:


angina pectoris, chest pain, edema

MGI Mouse Phenotypes related to Vasculitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.16 CD40LG MEFV CD79A MPO PRTN3 CTSG
2 cellular MP:0005384 10.1 CD40LG MEFV CD79A PRTN3 SELE CX3CL1
3 cardiovascular system MP:0005385 10.07 ICAM1 CD40LG MPO CRP SELE CX3CL1
4 homeostasis/metabolism MP:0005376 10.03 CD40LG MEFV CD79A MPO CRP SELE
5 immune system MP:0005387 9.89 CD40LG MEFV CD79A MPO CRP PRTN3
6 mortality/aging MP:0010768 9.44 ICAM1 CD40LG MEFV MPO CTSG SELE
Sources

Drugs & Therapeutics for Vasculitis

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PubMedHealth treatment related to Vasculitis: 63

Treatment for vasculitis will depend on the type of vasculitis you have, which organs are affected, and the severity of the condition.People who have severe vasculitis are treated with prescription medicines. Rarely, surgery may be done. People who have mild vasculitis may find relief with over-the-counter pain medicines, such as acetaminophen, aspirin, ibuprofen, or naproxen.The main goal of treating vasculitis is to reduce inflammation in the affected blood vessels. This usually is done by reducing or stopping the immune response that caused the inflammation.

Drugs for Vasculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 290)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
alemtuzumab Approved, Investigational Phase 4,Phase 2,Phase 1 216503-57-0
2
Menthol Approved Phase 4 2216-51-5 16666
3
Methotrexate Approved Phase 4,Phase 3,Phase 2,Not Applicable 1959-05-2, 59-05-2 126941
4
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-78-2 2244
5
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 22916-47-8 4189
6
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-18-0, 6055-19-2 2907
7
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-24-8 5755
8
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 24280-93-1 446541
9
Azathioprine Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 446-86-6 2265
10
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 128794-94-5 5281078
11
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 83-43-2 6741
12
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 4 67-73-2 6215
13
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
14
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 174722-31-7 10201696
15
Tazarotene Approved, Investigational Phase 4 118292-40-3 5381
16
Heparin Approved, Investigational Phase 4,Phase 3,Phase 1 9005-49-6 772 46507594
17
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
18
Colchicine Approved Phase 4,Phase 2 64-86-8 6167 2833
19
Everolimus Approved Phase 4 159351-69-6 6442177
20
Ibuprofen Approved Phase 4 15687-27-1 3672
21
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
22
Adalimumab Approved Phase 4,Phase 3 331731-18-1 16219006
23
Dalteparin Approved Phase 4,Phase 3,Phase 1 9005-49-6
24
Sirolimus Approved, Investigational Phase 4 53123-88-9 5284616 6436030 46835353
25
Anthralin Approved Phase 4 1143-38-0
26
Dapsone Approved, Investigational Phase 4,Phase 2 80-08-0 2955
27
Pravastatin Approved Phase 4,Phase 2 81093-37-0 54687
28
Ceftazidime Approved Phase 4 78439-06-2, 72558-82-8 5481173
29
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 58-05-9 143 6006
30
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 59-30-3 6037
31
Tocopherol Approved, Investigational, Nutraceutical Phase 4 1406-66-2 14986
32
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
33 Prednisolone acetate Phase 4,Phase 2,Phase 3,Not Applicable
34 Analgesics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
35 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
37 Fibrinolytic Agents Phase 4,Phase 3,Phase 1,Not Applicable
38 Methylprednisolone acetate Phase 4,Phase 2,Phase 3,Not Applicable
39 Methylprednisolone Hemisuccinate Phase 4,Phase 2,Phase 3,Not Applicable
40 Micronutrients Phase 4,Phase 3,Not Applicable
41 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
42 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Neuroprotective Agents Phase 4,Phase 2,Phase 3,Not Applicable
44 Cyclooxygenase Inhibitors Phase 4,Not Applicable
45 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
46 Cyclosporins Phase 4,Phase 3,Not Applicable,Early Phase 1
47 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
48 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Trace Elements Phase 4,Phase 3,Not Applicable
50 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 452)
# Name Status NCT ID Phase Drugs
1 Alemtuzumab for ANCA Associated Refractory Vasculitis Unknown status NCT01405807 Phase 4 Alemtuzumab
2 Prevention of Relapses in Proteinase 3 (PR3)-Anti-neutrophil Cytoplasmic Antibodies (ANCA)-Associated Vasculitis Unknown status NCT00128895 Phase 4 azathioprine
3 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
4 The Efficacy of Methylprednisolone in the Treatment of Patients With Ocular Involvement in Behcet's Disease Unknown status NCT01306955 Phase 4 methylorednisolone
5 CHUSPAN PAN BP Treatment of Polyarteritis Nodosa and Microscopic Polyangiitis Without Poor-Prognosis Factors Unknown status NCT00400075 Phase 4 azathioprine;cyclophosphamide
6 CHUSPAN SCS BP Treatment of Churg–Strauss Syndrome Without Poor-Prognosis Factors Unknown status NCT00399399 Phase 4 azathioprine;cyclophosphamide
7 Steroids Pharmacokinetics and the Response to Prednisone Therapy in Giant Cell Arteritis Unknown status NCT01400464 Phase 4 Prednisone therapy and pharmacokinetic
8 Flucinolone Acetonide Implant for Treating Refractory Ocular Behcet's Disease Unknown status NCT00720928 Phase 4 flucinolone acetonide
9 Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years Completed NCT00307671 Phase 4 prednisone, methylprednisolone,cyclophosphamides;Cyclophosphamide, Azathioprine,prednisone,methylprednisolone;Mycophenolate mofetil,methotrexate
10 Pilot Study of Short-Course Glucocorticoids and Rituximab for Treatment of ANCA-Associated Vasculitis Completed NCT02169219 Phase 4 Glucocorticoids;Rituximab
11 Tacrolimus in Children With Henoch-Schönlein Purpura Nephritis Completed NCT03222687 Phase 4 tacrolimus;prednisone
12 Study of the Influence of Plasma Exchange on the Pharmacokinetics of Rituximab Completed NCT00820469 Phase 4 Rituximab 375;rituximab 1000
13 Effect of Adalimumab on Vascular Inflammation in Patients With Moderate to Severe Plaque Psoriasis Completed NCT00940862 Phase 4
14 The Comparison of the Efficacy of Once and Twice Daily Colchicine Dosage in Pediatric Patients With FMF Completed NCT02602028 Phase 4 colchicine
15 Study Of The Safety And Efficacy Of Conversion From A CNI To Sirolimus In Renally-Impaired Heart Transplant Recipients Completed NCT00369382 Phase 4 cyclosporine or tacrolimus;sirolimus
16 Short Term Efficacy of a Starting Dose of 12.5 mg of Prednisone in Polymyalgia Rheumatica Patients Completed NCT01169597 Phase 4 prednisone
17 A Study to Evaluate the Efficacy and Safety of Zenapax in Combination With CellCept, Cyclosporine, and Corticosteroids in Patients Undergoing Cardiac Transplantation Completed NCT00048165 Phase 4 Daclizumab;Methylprednisolone;Mycophenolate mofetil;Placebo;cyclosporine
18 Study of Combined Therapy of Aspirin and "IVIG-SN" in Kawasaki Disease Completed NCT01524939 Phase 4 immunoglobulin G
19 Efficacy of Low Molecular Weight Heparin in Superficial Vein Thrombosis Completed NCT01245998 Phase 4 Dalteparin;Dalteparin
20 Saline vs. Lactated Ringers for Emergency Department IV Fluid Resuscitation Completed NCT03133767 Phase 4 Lactated Ringer Solution;Normal Saline 0.9% Infusion Solution Bag
21 Efficacy and Safety of Esarin Gel in Chronic Venous Insufficiency and Varicose Veins Completed NCT02346058 Phase 4 Esarin Gel
22 HSP-glomerulonephritis Trial: MP vs CyA Completed NCT00425724 Phase 4 Methylprednisolone pulses plus prednisone versus Cyclosporine A
23 Topical Diclofenac Gel in Patients With Superficial Inflammation of the Veins Completed NCT00377806 Phase 4 Diclofenac gel
24 Management of Superficial Thrombophlebitis Completed NCT00264381 Phase 4 Dalteparin sodium injection
25 Maintenance of ANCA Vasculitis Remission by Intermittent Rituximab Dosing Recruiting NCT02749292 Phase 4 Rituximab
26 Efficacy and Safety of H.P. ACTHAR GEL in Adults With Retinal Vasculitis Recruiting NCT03066869 Phase 4 H.P. ACTHAR GEL
27 Low-dose Glucocorticoid Vasculitis Induction Study Recruiting NCT02198248 Phase 4 Rituximab;Glucocorticoids
28 Maintenance of Remission With Rituximab Versus Azathioprine for Newly-diagnosed or Relapsing Eosinophilic Granulomatosis With Polyangiitis. Recruiting NCT03164473 Phase 4 Rituximab;Azathioprine;Placebo-rituximab;Placebo-azathioprine
29 Clinical Utility Of Genetic Screening For HLA-B*1301, On Susceptibility To Dapsone Hypersensitivity Syndrome Recruiting NCT02550080 Phase 4 Dapsone
30 Tocilizumab Dose-tapering and Interruption in Patients With Giant Cell Arteritis Achieving the Clinical Remission. Recruiting NCT03244709 Phase 4 Tocilizumab
31 The Impact of Neut During Potassium Chloride Replacement on Pain and Incidence of Phlebitis Enrolling by invitation NCT02082717 Phase 4 potassium chloride replacement;Experimental - 4% Sodium Bicarbonate
32 A Study Evaluating the Safety and Efficacy of Rituximab in Combination With Glucocorticoids in Participants With Wegener's Granulomatosis or Microscopic Polyangitis Suspended NCT02115997 Phase 4 Methylprednisolone;Prednisone;Rituximab
33 Normal Saline Versus Heparinized Solution Flush for Maintaining Patency of Peripheral Venous Catheters in Children Suspended NCT01794767 Phase 4 0,9% NaCl flush;Heparin 50U/ml
34 Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein Levels Terminated NCT00578578 Phase 4
35 Anti-Oxidant Therapy In Chronic Renal Insufficiency (ATIC) Study Terminated NCT00384618 Phase 4 pravastatin;vitamin E
36 Rituximab for the Otolaryngologic Manifestations of Granulomatosis With Polyangiitis Terminated NCT02626845 Phase 4 Rituximab
37 Interventional Cryotherapy for the Eradication of Benign Airway Disease ("ICE the BAD") Terminated NCT00747461 Phase 4
38 Cacicol20® in Corneal Wound Healing and Nerve Regeneration After Phototherapeutic Keratectomy Terminated NCT02373397 Phase 4
39 Prolonging the Duration of Peripheral Venous Catheters in Cystic Fibrosis People Terminated NCT00418470 Phase 4
40 WEGENT - Comparison of Methotrexate or Azathioprine as Maintenance Therapy for ANCA-Associated Vasculitides Unknown status NCT00349674 Phase 3 Azathioprine: 2 mg/kg/day;methotrexate 0.3 mg/kg/week, to a maximum and optimal dose of 25 mg/week
41 Mycophenolate Mofetil for Treatment of Relapses of Wegener's Disease or Microscopic Polyangiitis (MPA) Unknown status NCT00103792 Phase 3 mycophenolate mofetil;cyclophosphamide
42 Pain and Music Therapy in Patients Suffering Arteritis Unknown status NCT01323504 Phase 3
43 Efficacy and Safety of E-101 Solution for Preventing Surgical Site Infections After Colorectal Surgery Unknown status NCT01297959 Phase 3 E-101 Solution 300 GU/ml;Saline solution
44 Peripheral Venous Catheter Trial: 3 Day Versus No Routine Change Unknown status NCT00103636 Phase 2, Phase 3
45 Infliximab Therapy in Patients With Refractory Polymyalgia Rheumatica Unknown status NCT01423591 Phase 3 infliximab;inactive powder
46 Clinical Trial of Mycophenolate Versus Cyclophosphamide in ANCA Vasculitis Completed NCT00414128 Phase 2, Phase 3 mycophenolate mofetil;cyclophosphamide
47 Pulse Versus Continuous Cyclophosphamide for Induction of Remission in ANCA-Associated Vasculitides Completed NCT00430105 Phase 2, Phase 3 cyclophosphamide
48 Efficacy Study of Two Treatments in the Remission of Vasculitis Completed NCT00748644 Phase 3 Rituximab;Azathioprine
49 Belimumab in Remission of VASculitis Completed NCT01663623 Phase 3 Azathioprine
50 Comparison Study of Two Rituximab Regimens in the Remission of ANCA Associated Vasculitis Completed NCT01731561 Phase 3 Rituximab (Arm B);Rituximab (Arm A)

Search NIH Clinical Center for Vasculitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: vasculitis

Sources

Genetic Tests for Vasculitis

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Genetic tests related to Vasculitis:

# Genetic test Affiliating Genes
1 Vasculitis 29
Sources

Anatomical Context for Vasculitis

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MalaCards organs/tissues related to Vasculitis:

41
Neutrophil, Skin, Lung, Endothelial, T Cells, Heart, B Cells
Sources

Publications for Vasculitis

About this section

Articles related to Vasculitis:

(show top 50) (show all 3011)
# Title Authors Year
1
Anti-tubulin-I+-1C autoantibody in systemic lupus erythematosus: a novel indicator of disease activity and vasculitis manifestations. ( 29427009 )
2018
2
Cerebrospinal Fluid Findings in Reversible Cerebral Vasoconstriction Syndrome - A way to differentiate from Cerebral Vasculitis? ( 29722896 )
2018
3
Matrix Metalloprotease-9 (MMP-9)-Producing Monocytes Enable T Cells to Invade the Vessel Wall and Cause Vasculitis. ( 29970365 )
2018
4
Diffuse Alveolar Hemorrhage in IgA Vasculitis with an Atypical Presentation. ( 29033424 )
2018
5
Primary central nervous system vasculitis associated with lymphoma. ( 29429967 )
2018
6
Primary central nervous system vasculitis mimicking a brain tumor on conventional magnetic resonance imaging: the usefulness of perfusion-weighted imaging. A case report. ( 29516404 )
2018
7
Retinal vasculitis and Eales disease. ( 29599058 )
2018
8
Acute respiratory distress syndrome in a man with Epstein-Barr virus infection-induced hypocomplementemic urticarial vasculitis. ( 29458992 )
2018
9
An Autopsy Case of Myeloperoxidase-anti-neutrophil Cytoplasmic Antibody (MPO-ANCA) -associated Vasculitis Accompanied by Cryoglobulinemic Vasculitis Affecting the Kidneys, Skin, and Gastrointestinal Tract. ( 29709950 )
2018
10
The adenosinergic system: a potential player in the pathogenesis of ANCA-associated vasculitis? ( 29745882 )
2018
11
Red Blood Cell Distribution Width Can Predict Vasculitis Activity and Poor Prognosis in Granulomatosis with Polyangiitis. ( 29436199 )
2018
12
Efficacy of adalimumab and infliximab in recalcitrant retinal vasculitis inadequately responsive to other immunomodulatory therapies. ( 29766375 )
2018
13
Letter to the Editor: Time for cost-effectiveness studies for preventive strategies applied according to risk of cytomegalovirus-related morbidity and mortality in ANCA-associated vasculitis. ( 29663157 )
2018
14
18F-Fluorodeoxyglucose Positron Emission Tomography-computed Tomography in Evaluation of Large Vessel Vasculitis. ( 29430115 )
2018
15
Evaluation of efficacy of infliximab for retinal vasculitis and extraocular symptoms in BehAset disease. ( 29582190 )
2018
16
Isolated Cervical Cord Involvement in Primary Central Nervous System Vasculitis. ( 29961677 )
2018
17
Adult onset immunoglobulin A vasculitis (Henoch-Schonlein purpura) with alveolar hemorrhage. ( 29942747 )
2018
18
Propylthiouracil-induced ANCA-negative cutaneous small vessel vasculitis. ( 29441165 )
2018
19
Anti-neutrophil extracellular trap antibody in a patient with relapse of anti-neutrophil cytoplasmic antibody-associated vasculitis: a case report. ( 29929470 )
2018
20
Retinal Vasculitis in Takayasu's Arteritis. ( 29791818 )
2018
21
Leukocytoclastic Vasculitis (Hypersensitivity Vasculitis) ( 29489227 )
2018
22
Comparing immunoglobulin A vasculitis (Henoch-SchAPnlein purpura) in children and adults: a single-centre study from Turkey. ( 29912602 )
2018
23
Psychiatric and functional neuroimaging abnormalities in chronic hepatitis C virus patients: Is vasculitis a contributing factor? ( 29935864 )
2018
24
Multimodal imaging questions etiology of idiopathic retinal vasculitis, aneurysms and neuroretinitis syndrome (IRVAN syndrome). ( 29406987 )
2018
25
The treatment outcomes of rituximab for intractable otitis media with ANCA-associated vasculitis. ( 29885746 )
2018
26
Ipilimumab induced digital vasculitis. ( 29433584 )
2018
27
Rituximab for Sight-Threatening Lupus-Related Retinal Vasculitis. ( 29059086 )
2018
28
Excessive neutrophil extracellular trap formation in ANCA-associated vasculitis is independent of ANCA. ( 29606398 )
2018
29
Linked help from bacterial proteins drives autoantibody production in small vessel vasculitis. ( 29447930 )
2018
30
The first case of bacillus Calmette-GuAcrin-induced small-vessel central nervous system vasculitis. ( 29740727 )
2018
31
Renal-limited Cryoglobulinemic Vasculitis: Two Case Reports. ( 29962417 )
2018
32
Myeloperoxidase-ANCA-positive granulomatosis with polyangiitis is a distinct subset of ANCA-associated vasculitis: A retrospective analysis of 455 patients from a single center in China. ( 29887327 )
2018
33
Hemorrhagic Ischemic Retinal Vasculitis and Alopecia Areata as a Manifestation of HLA-B27. ( 29304269 )
2018
34
Vasculitis or coronary atherosclerosis? Optical coherence tomography images in polyarteritis nodosa. ( 29652433 )
2018
35
Sweet's Syndrome Mimicking ANCA-Associated Vasculitis. ( 29355513 )
2018
36
Staphylococcus-Associated Glomerulonephritis Mimicking Henoch-SchAPnlein Purpura and Cryoglobulinemic Vasculitis in a Patient With an Epidural Abscess: A Case Report and Brief Review of the Literature. ( 29900000 )
2018
37
PR3-ANCA: a potential biomarker of disease activity for propylthiouracil-induced ANCA-associated vasculitis. ( 29888703 )
2018
38
Cocaine and ANCA associated vasculitis-like syndromes - A case series. ( 29108823 )
2018
39
On hepatitis B virus and vasculitis. ( 29948001 )
2018
40
MicroRNA-145-5p and microRNA-320a encapsulated in endothelial microparticles contribute to the progression of vasculitis in acute Kawasaki Disease. ( 29343815 )
2018
41
Correction to: Voriconazole-induced periostitis deformans: serial imaging in a patient with ANCA vasculitis. ( 29353405 )
2018
42
Idiopathic Interstitial Pneumonia as a Possible Cause of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Case Report. ( 29901014 )
2018
43
Pulmonary Vasculitis and a Horseshoe Kidney in Noonan Syndrome. ( 29670795 )
2018
44
THE COLLABORATIVE OCULAR TUBERCULOSIS STUDY (COTS)-1: A Multinational Review of 251 Patients With Tubercular Retinal Vasculitis. ( 29697588 )
2018
45
Vasculitis of ascending aorta detected on FDG PET/CT in a patient with fever of unknown origin. ( 29942361 )
2018
46
The Utility of Urinalysis in Determining the Risk of Renal Relapse in ANCA-Associated Vasculitis. ( 29371340 )
2018
47
Avacopan in the treatment of ANCA-associated vasculitis. ( 29718732 )
2018
48
Vancomycin-associated hemorrhagic occlusive retinal vasculitis: a clinical-pathophysiological analysis. ( 29425799 )
2018
49
Late-onset Pneumocystis jirovecii pneumonia (PJP) in patients with ANCA-associated vasculitis. ( 29808456 )
2018
50
Risk Factors for Relapse of Antineutrophil Cytoplasmic Antibody-associated Vasculitis in Japan: A Nationwide, Prospective Cohort Study. ( 29419469 )
2018
Sources

Variations for Vasculitis

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ClinVar genetic disease variations for Vasculitis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CCM2 NM_031443.3(CCM2): c.1234C> T (p.Arg412Trp) single nucleotide variant Uncertain significance rs544276945 GRCh37 Chromosome 7, 45115555: 45115555
2 CCM2 NM_031443.3(CCM2): c.1234C> T (p.Arg412Trp) single nucleotide variant Uncertain significance rs544276945 GRCh38 Chromosome 7, 45075956: 45075956
3 COL4A2 NM_001846.3(COL4A2): c.1776+13A> G single nucleotide variant Uncertain significance GRCh37 Chromosome 13, 111114744: 111114744
4 COL4A2 NM_001846.3(COL4A2): c.1776+13A> G single nucleotide variant Uncertain significance GRCh38 Chromosome 13, 110462397: 110462397
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Expression for Vasculitis

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Search GEO for disease gene expression data for Vasculitis.
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Pathways for Vasculitis

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Pathways related to Vasculitis according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Cytokine Signaling in Immune system 66
Show member pathways
 13.23 CD40LG ICAM1 PRTN3 TNF TNFSF13B VCAM1
2
Innate Immune System 66
Show member pathways
 13.12 BPI CD40LG CD79A CRP CTSG ELANE
3
NF-kappaB Signaling 4
12.49 CD40LG CD79A MPO TNF TNFSF13B VCAM1
4
Defensins 66
Show member pathways
 12.21 BPI CTSG ELANE PRTN3
5
Folate Metabolism 1
Show member pathways
 12.17 CRP ICAM1 MPO TNF
6
Fluid shear stress and atherosclerosis 37
12.02 ICAM1 SELE THBD TNF VCAM1
7
Cell adhesion molecules (CAMs) 37
11.97 CD40LG ICAM1 SELE VCAM1
8
TNF signaling pathway 37
11.86 CX3CL1 ICAM1 SELE TNF VCAM1
9
AGE-RAGE signaling pathway in diabetic complications 37
11.76 ICAM1 SELE THBD TNF VCAM1
10
Amoebiasis 37
11.75 CTSG SERPINB1 TNF
11
Rheumatoid arthritis 37
11.71 ICAM1 TNF TNFSF13B
12
NF-kappa B signaling pathway 37
11.7 CD40LG ICAM1 TNF TNFSF13B VCAM1
13
C-MYB transcription factor network 1
11.64 ELANE MPO PRTN3
14
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway 22
Show member pathways
 11.59 CD40LG TNF TNFSF13B
15
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.45 CD40LG ICAM1 SELE TNF VCAM1
16
amb2 Integrin signaling 1
11.44 ELANE ICAM1 MPO TNF
17
Thromboxane A2 receptor signaling 1
11.35 ICAM1 SELE VCAM1
18
African trypanosomiasis 37
11.25 ICAM1 SELE TNF VCAM1
19
Malaria 37
11.04 CD40LG ICAM1 SELE TNF VCAM1
20
LDL Oxidation in Atherogenesis 64
10.66 ICAM1 MPO TNF VCAM1
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GO Terms for Vasculitis

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Cellular components related to Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.83 CD40LG CD79A ICAM1 TNF VCAM1
2 cell surface GO:0009986 9.81 APOH CD40LG CTSG CX3CL1 ELANE ICAM1
3 membrane raft GO:0045121 9.8 CD79A ICAM1 PRTN3 SELE TNF
4 extracellular matrix GO:0031012 9.8 APOH CTSG ICAM1 PRTN3 SERPINB1 VWF
5 extracellular region GO:0005576 9.8 APOH BPI CD40LG CRP CTSG CX3CL1
6 azurophil granule lumen GO:0035578 9.65 BPI CTSG ELANE MPO PRTN3
7 extracellular space GO:0005615 9.55 APOH BPI CD40LG CRP CTSG CX3CL1
8 extracellular exosome GO:0070062 10.15 APOH BPI CRP CTSG ELANE ICAM1

Biological processes related to Vasculitis according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.99 BPI CD40LG CTSG CX3CL1 TNF TNFSF13B
2 regulation of immune response GO:0050776 9.93 CD40LG ICAM1 TNFSF13B VCAM1
3 cytokine-mediated signaling pathway GO:0019221 9.92 CX3CL1 ICAM1 PRTN3 TNF VCAM1
4 extracellular matrix organization GO:0030198 9.91 ICAM1 TNF VCAM1 VWF
5 inflammatory response GO:0006954 9.91 CD40LG CRP CX3CL1 MEFV SELE TNF
6 blood coagulation GO:0007596 9.9 PRTN3 SERPINA1 THBD VWF
7 defense response to bacterium GO:0042742 9.88 BPI CTSG ELANE MPO TNF
8 neutrophil degranulation GO:0043312 9.87 BPI CTSG ELANE MPO PRTN3 SERPINA1
9 leukocyte migration GO:0050900 9.85 ELANE ICAM1 SELE THBD TNF
10 B cell differentiation GO:0030183 9.81 CD40LG CD79A VCAM1
11 positive regulation of T cell proliferation GO:0042102 9.78 CD40LG TNFSF13B VCAM1
12 hemostasis GO:0007599 9.77 SERPINA1 THBD VWF
13 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.76 ICAM1 SELE VCAM1
14 defense response to fungus GO:0050832 9.67 CTSG ELANE MPO
15 antimicrobial humoral response GO:0019730 9.67 BPI CTSG ELANE PRTN3
16 positive regulation of immune response GO:0050778 9.65 CTSG ELANE
17 negative regulation of fibrinolysis GO:0051918 9.64 APOH THBD
18 negative regulation of lipid storage GO:0010888 9.63 CRP TNF
19 acute inflammatory response to antigenic stimulus GO:0002438 9.62 ELANE ICAM1
20 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.62 ELANE TNF
21 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.58 ICAM1 TNF
22 leukocyte tethering or rolling GO:0050901 9.58 SELE TNF VCAM1
23 membrane to membrane docking GO:0022614 9.57 ICAM1 VCAM1
24 regulation of immunoglobulin secretion GO:0051023 9.56 CD40LG TNF
25 immunoglobulin secretion GO:0048305 9.55 CD40LG TNFSF13B
26 response to yeast GO:0001878 9.54 ELANE MPO
27 leukocyte cell-cell adhesion GO:0007159 9.46 CD40LG ICAM1 SELE VCAM1
28 leukocyte migration involved in inflammatory response GO:0002523 9.43 CX3CL1 ELANE SELE
29 negative regulation of growth of symbiont in host GO:0044130 9.26 CTSG ELANE MPO TNF
30 response to lipopolysaccharide GO:0032496 9.17 CTSG ELANE ICAM1 MPO SELE THBD

Molecular functions related to Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.62 CD40LG CX3CL1 TNF TNFSF13B
2 heparin binding GO:0008201 9.56 APOH CTSG ELANE MPO
3 tumor necrosis factor receptor binding GO:0005164 9.33 CD40LG TNF TNFSF13B
4 integrin binding GO:0005178 9.26 CX3CL1 ICAM1 VCAM1 VWF
5 protease binding GO:0002020 8.92 ELANE SERPINA1 TNF VWF
Sources

Sources for Vasculitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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