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MCID: VSC011
MIFTS: 67

Vasculitis

Categories: Blood diseases, Cardiovascular diseases, Immune diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Vasculitis

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MalaCards integrated aliases for Vasculitis:

Name: Vasculitis 12 77 54 30 56 6 44 45 15 17 74 64
Autoimmune Vasculitis 54 74
Angiitis 12 54
Vasculitis, Autoimmune 54

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Cardiovascular diseases Immune diseases Blood diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:865
MeSH 45 D014657
NCIt 51 C26912
SNOMED-CT 69 31996006
Sources

Summaries for Vasculitis

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NIH Rare Diseases : 54 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 52759Disease definitionVasculitis represents a clinically heterogenous group of diseases of multifactorial etiology characterized by inflammation of either large-sized vessels (large-vessel vasculitis, e.g. Giant-cell arteritis and Takayasu arteritis; see these terms), medium-sized vessels (medium-vessel vasculitis e.g. polyarteritis nodosa and Kawasaki disease; see these terms), or small-sized vessels (small-vessel vasculitis, e.g. granulomatosis with polyangiitis, microscopic polyangiitis, immunoglobulin A vasculitis, and cutaneous leukocytoclastic angiitis; see these terms). Vasculitis occurs at any age, may be acute or chronic, and manifests with general symptoms such as fever, weight loss and fatigue, as well as more specific clinical signs depending on the type of vessels and organs affected. The degree of severity is variable, ranging from life or sight threatening disease (e.g. Behçet disease, see this term) to relatively minor skin disease.Visit the Orphanet disease page for more resources.

MalaCards based summary : Vasculitis, also known as autoimmune vasculitis, is related to anca-associated vasculitis and lymphocytic vasculitis, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Vasculitis is PRTN3 (Proteinase 3), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs alemtuzumab and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, skin and t cells, and related phenotypes are hematopoietic system and cardiovascular system

Disease Ontology : 12 A vascular disease that is characterized by inflammation of the blood vessels.

MedlinePlus : 44 Vasculitis is an inflammation of the blood vessels. It happens when the body's immune system attacks the blood vessel by mistake. It can happen because of an infection, a medicine, or another disease. The cause is often unknown. Vasculitis can affect arteries, veins and capillaries. Arteries are vessels that carry blood from the heart to the body's organs. Veins are the vessels that carry blood back to the heart. Capillaries are tiny blood vessels that connect the small arteries and veins. When a blood vessel becomes inflamed, it can Narrow, making it more difficult for blood to get through Close off completely so that blood can't get through Stretch and weaken so much that it bulges. The bulge is called an aneurysm. If it bursts, it can cause dangerous bleeding inside the body. Symptoms of vasculitis can vary, but usually include fever, swelling and a general sense of feeling ill. The main goal of treatment is to stop the inflammation. Steroids and other medicines to stop inflammation are often helpful. NIH: National Heart, Lung, and Blood Institute

PubMed Health : 64 About vasculitis: Vasculitis (vas-kyu-LI-tis) is a condition that involves inflammation in the blood vessels. The condition occurs if your immune system attacks your blood vessels by mistake. This may happen as the result of an infection, a medicine, or another disease or condition.“Inflammation” refers to the body’s response to injury, including injury to the blood vessels. Inflammation may involve pain, redness, warmth, swelling, and loss of function in the affected tissues.In vasculitis, inflammation can lead to serious problems. Complications depend on which blood vessels, organs, or other body systems are affected.

Wikipedia : 77 Vasculitis is a group of disorders that destroy blood vessels by inflammation. Both arteries and veins... more...

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Related Diseases for Vasculitis

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Diseases in the Vasculitis family:

Autoimmune Vasculitis

Diseases related to Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 999)
# Related Disease Score Top Affiliating Genes
1 anca-associated vasculitis 34.4 MPO PRTN3 SERPINA1
2 lymphocytic vasculitis 34.3 ICAM1 SELE VCAM1
3 hypersensitivity vasculitis 34.2 CRP MEFV MPO PRTN3
4 rheumatoid vasculitis 34.1 CX3CL1 ICAM1 SELE TNF VCAM1
5 autoimmune vasculitis 33.7 CTSG ELANE
6 henoch-schoenlein purpura 33.2 CRP ICAM1 MEFV MPO VCAM1
7 churg-strauss syndrome 33.2 MPO PRTN3 THBD TNF
8 microscopic polyangiitis 32.9 CX3CL1 MPO TNF
9 temporal arteritis 32.7 APOH CCL2 CRP TNF
10 kawasaki disease 32.5 CCL2 CRP ELANE SELE TNF
11 arthus reaction 32.5 ELANE ICAM1 TNF
12 granulomatous angiitis 32.4 CRP PRTN3 THBD
13 alpha-1-antitrypsin deficiency 32.4 BPI ELANE SERPINA1
14 polyarteritis nodosa 32.3 APOH CRP MEFV MPO PRTN3 SELE
15 granulomatosis with polyangiitis 32.3 BPI CTSG ELANE MPO PRTN3 SERPINA1
16 behcet syndrome 32.0 APOH CRP MEFV SELE THBD TNF
17 vascular disease 31.1 APOH CCL2 CRP ELANE MPO SELE
18 uveitis 30.9 CCL2 ICAM1 TNF
19 meningitis 30.8 CCL2 CRP TNF
20 purpura 30.8 APOH CRP THBD TNF VWF
21 glomerulonephritis 30.5 CCL2 CD40LG ICAM1 MPO PRTN3 VCAM1
22 rapidly progressive glomerulonephritis 30.5 CRP ELANE ICAM1 MPO PRTN3
23 ulcerative colitis 30.5 BPI CRP MPO PRTN3 TNF
24 endocarditis 30.5 APOH CRP TNF VCAM1
25 mononeuritis multiplex 30.5 CRP MPO
26 crescentic glomerulonephritis 30.4 BPI CCL2 CTSG ICAM1 MPO VCAM1
27 cytomegalovirus infection 30.4 CCL2 CX3CL1 TNF
28 familial mediterranean fever 30.4 CRP MEFV TNF
29 infective endocarditis 30.3 APOH CRP TNF
30 immune-complex glomerulonephritis 30.3 ICAM1 MPO VCAM1
31 aortitis 30.3 CRP MPO
32 cutaneous lupus erythematosus 30.3 ICAM1 SELE TNF
33 respiratory failure 30.3 CRP ELANE SERPINA1 TNF
34 pericarditis 30.3 CRP MEFV TNF
35 connective tissue disease 30.3 APOH CD40LG TNF TNFSF13B
36 cholangitis 30.2 CRP PRTN3 TNF
37 cerebral aneurysms 30.2 CCL2 ELANE MPO
38 erysipelas 30.2 ELANE MEFV TNF
39 localized scleroderma 30.1 SELE TNF VCAM1
40 autoimmune disease 30.1 APOH CD40LG TNF TNFSF13B
41 multiple sclerosis 30.1 CCL2 ICAM1 TNF TNFSF13B VCAM1
42 reactive arthritis 30.1 BPI CRP TNF
43 spotted fever 30.1 THBD TNF VWF
44 leptospirosis 30.1 CCL2 CRP TNF
45 takayasu arteritis 30.1 CRP SELE THBD TNF VCAM1 VWF
46 chorioamnionitis 30.1 CCL2 CRP ELANE TNF
47 systemic lupus erythematosus 30.1 APOH CCL2 CD40LG CRP CTSG ELANE
48 brucellosis 30.0 CD40LG CRP MEFV TNF
49 thrombophilia due to thrombin defect 30.0 APOH THBD VWF
50 shwartzman phenomenon 30.0 ICAM1 TNF VCAM1

Graphical network of the top 20 diseases related to Vasculitis:



Diseases related to Vasculitis
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Symptoms & Phenotypes for Vasculitis

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UMLS symptoms related to Vasculitis:


angina pectoris, edema, chest pain

MGI Mouse Phenotypes related to Vasculitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 CD40LG CTSG CX3CL1 ELANE ICAM1 MEFV
2 cardiovascular system MP:0005385 10.07 CD40LG CRP CX3CL1 ICAM1 MPO SELE
3 cellular MP:0005384 10.06 CD40LG CX3CL1 ICAM1 MEFV PRTN3 SELE
4 homeostasis/metabolism MP:0005376 10 APOH CD40LG CRP CX3CL1 ELANE ICAM1
5 immune system MP:0005387 9.89 CCL2 CD40LG CRP CTSG CX3CL1 ELANE
6 mortality/aging MP:0010768 9.44 APOH CD40LG CTSG ELANE ICAM1 MEFV
Sources

Drugs & Therapeutics for Vasculitis

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PubMedHealth treatment related to Vasculitis: 64

Treatment for vasculitis will depend on the type of vasculitis you have, which organs are affected, and the severity of the condition.People who have severe vasculitis are treated with prescription medicines. Rarely, surgery may be done. People who have mild vasculitis may find relief with over-the-counter pain medicines, such as acetaminophen, aspirin, ibuprofen, or naproxen.The main goal of treating vasculitis is to reduce inflammation in the affected blood vessels. This usually is done by reducing or stopping the immune response that caused the inflammation.

Drugs for Vasculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 325)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
alemtuzumab Approved, Investigational Phase 4,Phase 2,Phase 1 216503-57-0
2
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 83-43-2 6741
3
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 2921-57-5
4
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 302-25-0
5
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-24-8 5755
6
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 6055-19-2, 50-18-0 2907
7
Azathioprine Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 446-86-6 2265
8
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
9
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 4 67-73-2 6215
10
leucovorin Approved Phase 4,Phase 3,Phase 2,Not Applicable 58-05-9 6006 143
11
Methotrexate Approved Phase 4,Phase 3,Phase 2,Not Applicable 1959-05-2, 59-05-2 126941
12
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 24280-93-1 446541
13
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 22916-47-8 4189
14
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-78-2 2244
15
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 174722-31-7 10201696
16
Tacrolimus Approved, Investigational Phase 4,Phase 1 104987-11-3 445643 439492 6473866
17
Tazarotene Approved, Investigational Phase 4 118292-40-3 5381
18
Anthralin Approved Phase 4 1143-38-0
19
Adalimumab Approved Phase 4,Phase 3 331731-18-1 16219006
20
Colchicine Approved Phase 4,Phase 2 64-86-8 6167 2833
21
Everolimus Approved Phase 4 159351-69-6 6442177 70789204
22
Sirolimus Approved, Investigational Phase 4 53123-88-9 46835353 6436030 5284616
23
Dalteparin Approved Phase 4,Phase 3,Phase 1,Phase 2 9005-49-6
24
Heparin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 9005-49-6 772 46507594
25
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
26
Ibuprofen Approved Phase 4,Phase 3 15687-27-1 3672
27
Adenosine Approved, Investigational Phase 4,Not Applicable 58-61-7 60961
28
Dapsone Approved, Investigational Phase 4,Phase 2 80-08-0 2955
29
Pentoxifylline Approved, Investigational Phase 4,Phase 2 6493-05-6 4740
30
Tocopherol Approved, Investigational Phase 4 1406-66-2 14986
31
Pravastatin Approved Phase 4,Phase 2 81093-37-0 54687
32
Ceftazidime Approved Phase 4 78439-06-2, 72558-82-8 5481173
33
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 59-30-3 6037
34
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 7440-70-2 271
35
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
36
Prednisolone hemisuccinate Experimental Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 2920-86-7
37 Tocotrienol Investigational Phase 4 6829-55-6
38 Antineoplastic Agents, Immunological Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
40 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
42 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
43 Prednisolone acetate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
44 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
45 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
46 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
47 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
48 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
49 Methylprednisolone Acetate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
50 Neuroprotective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 505)
# Name Status NCT ID Phase Drugs
1 Alemtuzumab for ANCA Associated Refractory Vasculitis Unknown status NCT01405807 Phase 4 Alemtuzumab
2 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
3 The Efficacy of Methylprednisolone in the Treatment of Patients With Ocular Involvement in Behcet's Disease Unknown status NCT01306955 Phase 4 methylorednisolone
4 CHUSPAN PAN BP Treatment of Polyarteritis Nodosa and Microscopic Polyangiitis Without Poor-Prognosis Factors Unknown status NCT00400075 Phase 4 azathioprine;cyclophosphamide
5 CHUSPAN SCS BP Treatment of Churg–Strauss Syndrome Without Poor-Prognosis Factors Unknown status NCT00399399 Phase 4 azathioprine;cyclophosphamide
6 Steroids Pharmacokinetics and the Response to Prednisone Therapy in Giant Cell Arteritis Unknown status NCT01400464 Phase 4 Prednisone therapy and pharmacokinetic
7 Flucinolone Acetonide Implant for Treating Refractory Ocular Behcet's Disease Unknown status NCT00720928 Phase 4 flucinolone acetonide
8 Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years Completed NCT00307671 Phase 4 prednisone, methylprednisolone,cyclophosphamides;Cyclophosphamide, Azathioprine,prednisone,methylprednisolone;Mycophenolate mofetil,methotrexate
9 Pilot Study of Short-Course Glucocorticoids and Rituximab for Treatment of ANCA-Associated Vasculitis Completed NCT02169219 Phase 4 Glucocorticoids;Rituximab
10 Tacrolimus in Children With Henoch-Schönlein Purpura Nephritis Completed NCT03222687 Phase 4 tacrolimus;prednisone
11 Study of the Influence of Plasma Exchange on the Pharmacokinetics of Rituximab Completed NCT00820469 Phase 4 Rituximab 375;rituximab 1000
12 Effect of Adalimumab on Vascular Inflammation in Patients With Moderate to Severe Plaque Psoriasis Completed NCT00940862 Phase 4
13 The Comparison of the Efficacy of Once and Twice Daily Colchicine Dosage in Pediatric Patients With FMF Completed NCT02602028 Phase 4 colchicine
14 Study Of The Safety And Efficacy Of Conversion From A CNI To Sirolimus In Renally-Impaired Heart Transplant Recipients Completed NCT00369382 Phase 4 cyclosporine or tacrolimus;sirolimus
15 Short Term Efficacy of a Starting Dose of 12.5 mg of Prednisone in Polymyalgia Rheumatica Patients Completed NCT01169597 Phase 4 prednisone
16 A Study to Evaluate the Efficacy and Safety of Zenapax in Combination With CellCept, Cyclosporine, and Corticosteroids in Patients Undergoing Cardiac Transplantation Completed NCT00048165 Phase 4 Daclizumab;Methylprednisolone;Mycophenolate mofetil;Placebo;cyclosporine
17 Study of Combined Therapy of Aspirin and "IVIG-SN" in Kawasaki Disease Completed NCT01524939 Phase 4 immunoglobulin G
18 Efficacy of Low Molecular Weight Heparin in Superficial Vein Thrombosis Completed NCT01245998 Phase 4 Dalteparin;Dalteparin
19 Saline vs. Lactated Ringers for Emergency Department IV Fluid Resuscitation Completed NCT03133767 Phase 4 Lactated Ringer Solution;Normal Saline 0.9% Infusion Solution Bag
20 Efficacy and Safety of Esarin Gel in Chronic Venous Insufficiency and Varicose Veins Completed NCT02346058 Phase 4 Esarin Gel
21 HSP-glomerulonephritis Trial: MP vs CyA Completed NCT00425724 Phase 4 Methylprednisolone pulses plus prednisone versus Cyclosporine A
22 Topical Diclofenac Gel in Patients With Superficial Inflammation of the Veins Completed NCT00377806 Phase 4 Diclofenac gel
23 Management of Superficial Thrombophlebitis Completed NCT00264381 Phase 4 Dalteparin sodium injection
24 Maintenance of ANCA Vasculitis Remission by Intermittent Rituximab Dosing Recruiting NCT02749292 Phase 4 Rituximab
25 Low-dose Glucocorticoid Vasculitis Induction Study Recruiting NCT02198248 Phase 4 Rituximab;Glucocorticoids
26 A Study Evaluating the Safety and Efficacy of Rituximab in Combination With Glucocorticoids in Participants With Wegener's Granulomatosis or Microscopic Polyangitis Recruiting NCT02115997 Phase 4 Methylprednisolone;Prednisone;Rituximab
27 Maintenance of Remission With Rituximab Versus Azathioprine for Newly-diagnosed or Relapsing Eosinophilic Granulomatosis With Polyangiitis. Recruiting NCT03164473 Phase 4 Rituximab;Azathioprine;Placebo-rituximab;Placebo-azathioprine
28 Clinical Utility Of Genetic Screening For HLA-B*1301, On Susceptibility To Dapsone Hypersensitivity Syndrome Recruiting NCT02550080 Phase 4 Dapsone
29 Tocilizumab Plus a Short Prednisone Taper for GCA Recruiting NCT03726749 Phase 4 Tocilizumab;Prednisone
30 Tocilizumab Dose-tapering and Interruption in Patients With Giant Cell Arteritis Achieving the Clinical Remission. Recruiting NCT03244709 Phase 4 Tocilizumab
31 Efficacy and Safety of H.P. ACTHAR GEL in Adults With Retinal Vasculitis Active, not recruiting NCT03066869 Phase 4 H.P. ACTHAR GEL
32 Combined Pneumococcal Conjugate and Polysaccharide Vaccination in Inflammatory Rheumatic Disease Active, not recruiting NCT03762824 Phase 4
33 The Impact of Neut During Potassium Chloride Replacement on Pain and Incidence of Phlebitis Enrolling by invitation NCT02082717 Phase 4 potassium chloride replacement;Experimental - 4% Sodium Bicarbonate
34 Pentoxifylline in Lupus Nephritis Not yet recruiting NCT03859570 Phase 4 Pentoxifylline;Placebos
35 Normal Saline Versus Heparinized Solution Flush for Maintaining Patency of Peripheral Venous Catheters in Children Suspended NCT01794767 Phase 4 0,9% NaCl flush;Heparin 50U/ml
36 Prevention of Relapses in Proteinase 3 (PR3)-Anti-neutrophil Cytoplasmic Antibodies (ANCA)-Associated Vasculitis Terminated NCT00128895 Phase 4 azathioprine
37 Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein Levels Terminated NCT00578578 Phase 4
38 Anti-Oxidant Therapy In Chronic Renal Insufficiency (ATIC) Study Terminated NCT00384618 Phase 4 pravastatin;vitamin E
39 Rituximab for the Otolaryngologic Manifestations of Granulomatosis With Polyangiitis Terminated NCT02626845 Phase 4 Rituximab
40 Interventional Cryotherapy for the Eradication of Benign Airway Disease ("ICE the BAD") Terminated NCT00747461 Phase 4
41 Cacicol20® in Corneal Wound Healing and Nerve Regeneration After Phototherapeutic Keratectomy Terminated NCT02373397 Phase 4
42 Prolonging the Duration of Peripheral Venous Catheters in Cystic Fibrosis People Terminated NCT00418470 Phase 4
43 WEGENT - Comparison of Methotrexate or Azathioprine as Maintenance Therapy for ANCA-Associated Vasculitides Unknown status NCT00349674 Phase 3 Azathioprine: 2 mg/kg/day;methotrexate 0.3 mg/kg/week, to a maximum and optimal dose of 25 mg/week
44 Mycophenolate Mofetil for Treatment of Relapses of Wegener's Disease or Microscopic Polyangiitis (MPA) Unknown status NCT00103792 Phase 3 mycophenolate mofetil;cyclophosphamide
45 Comparison of Mycophenolate Mofetil and Cyclophosphamide for Active Takayasu's Arteritis Unknown status NCT03096275 Phase 3 MMF;CYC;Glucocorticoids;MTX;AZA
46 Pain and Music Therapy in Patients Suffering Arteritis Unknown status NCT01323504 Phase 3
47 Efficacy and Safety of E-101 Solution for Preventing Surgical Site Infections After Colorectal Surgery Unknown status NCT01297959 Phase 3 E-101 Solution 300 GU/ml;Saline solution
48 Peripheral Venous Catheter Trial: 3 Day Versus No Routine Change Unknown status NCT00103636 Phase 2, Phase 3
49 Infliximab Therapy in Patients With Refractory Polymyalgia Rheumatica Unknown status NCT01423591 Phase 3 infliximab;inactive powder
50 Clinical Trial of Mycophenolate Versus Cyclophosphamide in ANCA Vasculitis Completed NCT00414128 Phase 2, Phase 3 mycophenolate mofetil;cyclophosphamide

Search NIH Clinical Center for Vasculitis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: vasculitis

Sources

Genetic Tests for Vasculitis

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Genetic tests related to Vasculitis:

# Genetic test Affiliating Genes
1 Vasculitis 30
Sources

Anatomical Context for Vasculitis

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MalaCards organs/tissues related to Vasculitis:

42
Neutrophil, Skin, T Cells, Endothelial, B Cells, Kidney, Brain
Sources

Publications for Vasculitis

About this section

Articles related to Vasculitis:

(show top 50) (show all 5603)
# Title Authors Year
1
Acute Posterior Multifocal Placoid Pigment Epitheliopathy Complicated by Fatal Cerebral Vasculitis. ( 30676416 )
2019
2
Extensive purpuric lesions due to vitamin C deficiency and leucocytoclastic vasculitis as the initial sign of lung adenocarcinoma. ( 30687951 )
2019
3
Clinical impact of alpha-1-antitrypsin deficiency in ANCA-associated vasculitis: results from a French retrospective monocentric cohort of 142 consecutive patients. ( 30824651 )
2019
4
Updating OMERACT Core Set of Domains for ANCA-Associated Vasculitis: Patient Perspective Using the International Classification of Function, Disability and Health. ( 30709951 )
2019
5
Prognostic nutritional index is associated with disease severity and relapse in ANCA-associated vasculitis. ( 30729693 )
2019
6
Consideration concerning similarities and differences between ANCA-associated vasculitis and IgG-4-related diseases: case series and review of literature. ( 30734199 )
2019
7
Changing landscape of immunosuppression in ANCA-associated vasculitis. ( 30755415 )
2019
8
Rituximab prescription patterns and efficacy in the induction treatment of ANCA-Associated Vasculitis in a Belgian multicenter cohort. ( 30767717 )
2019
9
Intravenous pulse methylprednisolone for induction of remission in severe ANCA associated Vasculitis: a multi-center retrospective cohort study. ( 30777023 )
2019
10
Persistent antiphospholipid antibodies are associated with thrombotic events in ANCA-associated vasculitis: A retrospective monocentric study. ( 30798998 )
2019
11
Clinical impact of subgrouping ANCA-associated vasculitis according to antibody specificity beyond the clinicopathological classification. ( 30805643 )
2019
12
Diffuse alveolar hemorrhage in a patient with ANCA-associated vasculitis after thyroidectomy: A case report. ( 30813199 )
2019
13
Immunoglobulins G from patients with ANCA-associated vasculitis are atypically glycosylated in both the Fc and Fab regions and the relation to disease activity. ( 30818380 )
2019
14
MYCYC: unravelling the long road ahead in ANCA-associated vasculitis. ( 30894345 )
2019
15
Evaluation of PR3-ANCA Status After Rituximab for ANCA-Associated Vasculitis. ( 30896460 )
2019
16
Clinical and histopathological prognostic factors affecting the renal outcomes in childhood ANCA-associated vasculitis. ( 30607566 )
2019
17
Mycophenolate mofetil versus cyclophosphamide for remission induction in ANCA-associated vasculitis: a randomised, non-inferiority trial. ( 30612116 )
2019
18
Hypertrophic pachymeningitis and cerebral venous thrombosis in myeloperoxidase-ANCA associated vasculitis. ( 30635307 )
2019
19
Author Correction: Pathogenesis and therapeutic interventions for ANCA-associated vasculitis. ( 30655606 )
2019
20
Efficacy and Safety of Belimumab and Azathioprine for Maintenance of Remission in ANCA-Associated Vasculitis: A Randomized Controlled Study. ( 30666823 )
2019
21
Low-dose rituximab as induction therapy for ANCA-associated vasculitis. ( 30680533 )
2019
22
Aortitis and pachymeningitis: an unusual combination in granulomatosis with polyangiitis (myeloperoxidase-associated vasculitis). ( 30696638 )
2019
23
Primary central nervous system vasculitis mimicking brain tumor: Comprehensive analysis of 13 cases from a single institutional cohort of 191 cases. ( 30528173 )
2019
24
A case of central nervous system vasculitis presenting as a mass-like lesion. ( 30610477 )
2019
25
Study on the Clinical, Imaging, and Pathological Characteristics of 18 Cases with Primary Central Nervous System Vasculitis. ( 30635219 )
2019
26
Hospital Onset Varicella Central Nervous System Vasculitis in a Patient with HIV Infection. ( 30715900 )
2019
27
MOG antibody disease manifesting as progressive cognitive deterioration and behavioral changes with primary central nervous system vasculitis. ( 30738279 )
2019
28
Rituximab therapy for primary central nervous system vasculitis: A 6 patient experience and review of the literature. ( 30743080 )
2019
29
Primary central nervous system vasculitis in India - need for a multicenter prospective cohort study. ( 30860107 )
2019
30
Concomitant cryoglobulinemic vasculitis and cold agglutinin disease successfully treated with bortezomib: A case report. ( 30681592 )
2019
31
Cutaneous small-vessel vasculitis associated with paediatric ulcerative colitis: A case study and literature review. ( 30895688 )
2019
32
Supplementing Dermatology Physician Resident Education in Vasculitis and Autoimmune Connective Tissue Disease: A Prospective Study of an Online Curriculum. ( 30624565 )
2019
33
Sudden unexpected death due to coronary thrombosis associated with isolated necrotizing vasculitis in the coronary arteries of a young adult. ( 30810977 )
2019
34
Crohn's disease complicated by IgA vasculitis during tumor necrosis factor-α inhibitor therapy. ( 30733426 )
2019
35
MPO-ANCA-positive cutaneous polyarteritis nodosa with livedo racemosa arising from immune-deposit-positive necrotizing vasculitis. ( 30636392 )
2019
36
Anti-MOG encephalitis mimicking small vessel CNS vasculitis. ( 30800721 )
2019
37
Progressive stenosis and radiological findings of vasculitis over the entire internal carotid artery in moyamoya vasculopathy associated with graves' disease: a case report and review of the literature. ( 30825882 )
2019
38
Long-lasting persistence of large B-cell clones in HCV-cured patients with complete response of mixed cryoglobulinemia vasculitis. ( 30690862 )
2019
39
Hypocomplementemic urticarial vasculitis and multiple Sclerosis: A rare association or an atypical presentation? ( 30849680 )
2019
40
A case report of leukocytoclastic vasculitis after vaccination in a patient with inflammatory bowel disease. ( 30859841 )
2019
41
Association of MUC5B promoter polymorphism with interstitial lung disease in myeloperoxidase-antineutrophil cytoplasmic antibody-associated vasculitis. ( 30765393 )
2019
42
Myocardial fibrosis after adrenergic stimulation as a long-term sequela in a mouse model of Kawasaki disease vasculitis. ( 30728329 )
2019
43
Hereditary leukodystrophy with axonal spheroids (HDLS) presenting subacutely: a CNS-vasculitis mimic. ( 30747335 )
2019
44
Pulmonary Vein Vasculitis Presenting as Multiple Pulmonary Nodules in a Patient with Systemic Lupus Erythematosus. ( 30824668 )
2019
45
Systemic Lupus Erythematosus (SLE) and Antineutrophil Cytoplasmic Antibody-Associated Vasculitis (AAV) Overlap Syndrome: Case Report and Review of the Literature. ( 30723567 )
2019
46
Cerebral vasculitis associated with an Echovirus 6 meningoencephalitis-Case report and review of the literature. ( 30847187 )
2019
47
Hypersensitivity Myocarditis and Necrotizing Coronary Vasculitis by Clomipramine Causing Steroid-Sensitive Cardiogenic Shock. ( 30744394 )
2019
48
Combined checkpoint inhibitor-associated myocarditis and pulmonary vasculitis mimicking acute pulmonary embolism. ( 30535006 )
2019
49
Vasculitis and peripheral neuropathy. ( 30461543 )
2019
50
Idiopathic retinal vasculitis, aneurysms and neuroretinitis (IRVAN): case series of three patients with multimodal imaging. ( 30877369 )
2019
Sources

Variations for Vasculitis

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ClinVar genetic disease variations for Vasculitis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CCM2 NM_031443.3(CCM2): c.1234C> T (p.Arg412Trp) single nucleotide variant Uncertain significance rs544276945 GRCh37 Chromosome 7, 45115555: 45115555
2 CCM2 NM_031443.3(CCM2): c.1234C> T (p.Arg412Trp) single nucleotide variant Uncertain significance rs544276945 GRCh38 Chromosome 7, 45075956: 45075956
3 COL4A2 NM_001846.3(COL4A2): c.1776+13A> G single nucleotide variant Uncertain significance rs1555330577 GRCh37 Chromosome 13, 111114744: 111114744
4 COL4A2 NM_001846.3(COL4A2): c.1776+13A> G single nucleotide variant Uncertain significance rs1555330577 GRCh38 Chromosome 13, 110462397: 110462397
Sources

Expression for Vasculitis

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Search GEO for disease gene expression data for Vasculitis.
Sources

Pathways for Vasculitis

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Pathways related to Vasculitis according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 13.75 BPI CCL2 CD40LG CRP CTSG ELANE
2
Cytokine Signaling in Immune system 67
Show member pathways
 13.29 CCL2 CD40LG ICAM1 PRTN3 TNF TNFSF13B
3
NF-kappaB Signaling 4
12.49 CCL2 CD40LG MPO TNF TNFSF13B VCAM1
4
Development VEGF signaling via VEGFR2 - generic cascades 23
Show member pathways
 12.32 CCL2 ICAM1 SELE VCAM1
5
Defensins 67
Show member pathways
 12.28 BPI CTSG ELANE PRTN3
6
Selenium Micronutrient Network 1
Show member pathways
 12.26 CCL2 CRP ICAM1 MPO TNF
7
Cell adhesion molecules (CAMs) 38
12.04 CD40LG ICAM1 SELE VCAM1
8
Fluid shear stress and atherosclerosis 38
11.99 CCL2 ICAM1 SELE THBD TNF VCAM1
9
Spinal Cord Injury 1
11.94 CCL2 ICAM1 TNF TNFSF13B
10
Interleukin-4 and 13 signaling 67
11.91 CCL2 ICAM1 TNF VCAM1
11
TNF signaling pathway 38
11.84 CCL2 CX3CL1 ICAM1 SELE TNF VCAM1
12
Matrix Metalloproteinases 1
Show member pathways
 11.82 CTSG ELANE TNF
13
NF-kappa B signaling pathway 38
11.81 CD40LG ICAM1 TNF TNFSF13B VCAM1
14
Amoebiasis 38
11.8 CTSG SERPINB1 TNF
15
Rheumatoid arthritis 38
11.8 CCL2 ICAM1 TNF TNFSF13B
16
C-MYB transcription factor network 1
11.7 ELANE MPO PRTN3
17
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway 23
Show member pathways
 11.66 CD40LG TNF TNFSF13B
18
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.64 CCL2 CX3CL1 TNF
19
AGE-RAGE signaling pathway in diabetic complications 38
11.63 CCL2 ICAM1 SELE THBD TNF VCAM1
20
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.6 CD40LG ICAM1 SELE TNF VCAM1
21
Lung fibrosis 1
11.58 CCL2 SERPINA1 TNF
22
Interleukin-10 signaling 67
11.46 CCL2 ICAM1 TNF
23
amb2 Integrin signaling 1
11.46 ELANE ICAM1 MPO TNF
24
Thromboxane A2 receptor signaling 1
11.42 ICAM1 SELE VCAM1
25
African trypanosomiasis 38
11.33 ICAM1 SELE TNF VCAM1
26
A-beta Pathways: Uptake and Degradation 66
11.25 CCL2 CD40LG CX3CL1
27
G-protein signaling_RhoB regulation pathway 23
11.14 CCL2 CD40LG CX3CL1 TNF TNFSF13B
28
Malaria 38
11.12 CCL2 CD40LG ICAM1 SELE TNF VCAM1
29
G-protein signaling_Rap2B regulation pathway 23
10.94 CCL2 CD40LG CX3CL1 TNF TNFSF13B
30
LDL Oxidation in Atherogenesis 65
10.23 CCL2 ICAM1 MPO TNF VCAM1
Sources

GO Terms for Vasculitis

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Cellular components related to Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.91 APOH CD40LG CTSG CX3CL1 ELANE ICAM1
2 extracellular region GO:0005576 9.83 APOH BPI CCL2 CD40LG CRP CTSG
3 collagen-containing extracellular matrix GO:0062023 9.76 APOH CTSG ELANE ICAM1 PRTN3 SERPINA1
4 azurophil granule lumen GO:0035578 9.72 BPI CTSG ELANE MPO PRTN3
5 membrane raft GO:0045121 9.71 ICAM1 PRTN3 SELE TNF
6 extracellular space GO:0005615 9.58 APOH BPI CCL2 CD40LG CRP CTSG
7 extracellular exosome GO:0070062 10.11 APOH BPI CTSG ELANE ICAM1 MPO

Biological processes related to Vasculitis according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.98 CCL2 CX3CL1 ICAM1 TNF
2 immune response GO:0006955 9.98 BPI CCL2 CD40LG CTSG CX3CL1 TNF
3 regulation of immune response GO:0050776 9.96 CD40LG ICAM1 TNFSF13B VCAM1
4 extracellular matrix organization GO:0030198 9.95 ICAM1 TNF VCAM1 VWF
5 leukocyte migration GO:0050900 9.93 ELANE ICAM1 SELE TNF
6 blood coagulation GO:0007596 9.93 PRTN3 SERPINA1 THBD VWF
7 cellular response to lipopolysaccharide GO:0071222 9.91 CCL2 CTSG ICAM1 TNF
8 neutrophil degranulation GO:0043312 9.91 BPI CTSG ELANE MPO PRTN3 SERPINA1
9 defense response to bacterium GO:0042742 9.89 BPI CTSG ELANE MPO TNF
10 cytokine-mediated signaling pathway GO:0019221 9.88 CCL2 CX3CL1 ICAM1 PRTN3 TNF VCAM1
11 cellular response to interferon-gamma GO:0071346 9.87 CCL2 CX3CL1 ICAM1
12 defense response to Gram-positive bacterium GO:0050830 9.87 CRP CTSG TNF
13 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.87 CD40LG CX3CL1 ICAM1 TNF
14 cell chemotaxis GO:0060326 9.86 CCL2 CX3CL1 VCAM1
15 cellular response to interleukin-1 GO:0071347 9.86 CCL2 CX3CL1 ICAM1
16 cellular response to tumor necrosis factor GO:0071356 9.84 CCL2 CX3CL1 ICAM1 VCAM1
17 tumor necrosis factor-mediated signaling pathway GO:0033209 9.83 CD40LG TNF TNFSF13B
18 positive regulation of T cell proliferation GO:0042102 9.81 CD40LG TNFSF13B VCAM1
19 positive regulation of smooth muscle cell proliferation GO:0048661 9.8 CX3CL1 ELANE TNF
20 inflammatory response GO:0006954 9.8 CCL2 CD40LG CRP CX3CL1 MEFV SELE
21 hemostasis GO:0007599 9.79 SERPINA1 THBD VWF
22 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.76 ICAM1 SELE VCAM1
23 antimicrobial humoral response GO:0019730 9.76 BPI CTSG ELANE PRTN3
24 negative regulation of blood coagulation GO:0030195 9.7 APOH THBD
25 defense response to fungus GO:0050832 9.7 CTSG ELANE MPO
26 macrophage chemotaxis GO:0048246 9.69 CCL2 CX3CL1
27 negative regulation of interleukin-6 production GO:0032715 9.69 BPI CX3CL1 TNF
28 negative regulation of fibrinolysis GO:0051918 9.68 APOH THBD
29 negative regulation of interleukin-1 beta production GO:0032691 9.67 CX3CL1 MEFV
30 positive regulation of immune response GO:0050778 9.67 CTSG ELANE
31 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.67 ELANE TNF
32 negative regulation of lipid storage GO:0010888 9.66 CRP TNF
33 leukocyte tethering or rolling GO:0050901 9.65 SELE TNF VCAM1
34 acute inflammatory response to antigenic stimulus GO:0002438 9.64 ELANE ICAM1
35 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.61 ICAM1 TNF
36 membrane to membrane docking GO:0022614 9.6 ICAM1 VCAM1
37 regulation of immunoglobulin secretion GO:0051023 9.59 CD40LG TNF
38 immunoglobulin secretion GO:0048305 9.56 CD40LG TNFSF13B
39 response to yeast GO:0001878 9.55 ELANE MPO
40 leukocyte migration involved in inflammatory response GO:0002523 9.5 CX3CL1 ELANE SELE
41 leukocyte cell-cell adhesion GO:0007159 9.46 CD40LG ICAM1 SELE VCAM1
42 negative regulation of growth of symbiont in host GO:0044130 9.26 CTSG ELANE MPO TNF
43 response to lipopolysaccharide GO:0032496 9.17 CTSG ELANE ICAM1 MPO SELE THBD
44 regulation of signaling receptor activity GO:0010469 10.05 CCL2 CD40LG CX3CL1 TNF TNFSF13B
45 cell adhesion GO:0007155 10.05 CCL2 CX3CL1 ICAM1 SELE VCAM1 VWF

Molecular functions related to Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.62 APOH CTSG ELANE MPO
2 integrin binding GO:0005178 9.56 CX3CL1 ICAM1 VCAM1 VWF
3 tumor necrosis factor receptor binding GO:0005164 9.33 CD40LG TNF TNFSF13B
4 protease binding GO:0002020 9.26 ELANE SERPINA1 TNF VWF
5 cytokine activity GO:0005125 9.02 CCL2 CD40LG CX3CL1 TNF TNFSF13B
Sources

Sources for Vasculitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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