MCID: VSC011
MIFTS: 66

Vasculitis

Categories: Blood diseases, Cardiovascular diseases, Immune diseases, Rare diseases

Aliases & Classifications for Vasculitis

MalaCards integrated aliases for Vasculitis:

Name: Vasculitis 12 76 53 29 55 6 43 44 15 63 73
Autoimmune Vasculitis 53 73
Angiitis 12 53
Vasculitis, Autoimmune 53

Classifications:



External Ids:

Disease Ontology 12 DOID:865
MeSH 44 D014657
NCIt 50 C26912
SNOMED-CT 68 31996006

Summaries for Vasculitis

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 52759Disease definitionVasculitis represents a clinically heterogenous group of diseases of multifactorial etiology characterized by inflammation of either large-sized vessels (large-vessel vasculitis, e.g. Giant-cell arteritis and Takayasu arteritis; see these terms), medium-sized vessels (medium-vessel vasculitis e.g. polyarteritis nodosa and Kawasaki disease; see these terms), or small-sized vessels (small-vessel vasculitis, e.g. granulomatosis with polyangiitis, microscopic polyangiitis, immunoglobulin A vasculitis, and cutaneous leukocytoclastic angiitis; see these terms). Vasculitis occurs at any age, may be acute or chronic, and manifests with general symptoms such as fever, weight loss and fatigue, as well as more specific clinical signs depending on the type of vessels and organs affected. The degree of severity is variable, ranging from life or sight threatening disease (e.g. Behçet disease, see this term) to relatively minor skin disease.Visit the Orphanet disease page for more resources.

MalaCards based summary : Vasculitis, also known as autoimmune vasculitis, is related to hypersensitivity vasculitis and lymphocytic vasculitis, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Vasculitis is PRTN3 (Proteinase 3), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Innate Immune System. The drugs alemtuzumab and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, endothelial and skin, and related phenotypes are hematopoietic system and cellular

Disease Ontology : 12 A vascular disease that is characterized by inflammation of the blood vessels.

MedlinePlus : 43 Vasculitis is an inflammation of the blood vessels. It happens when the body's immune system attacks the blood vessel by mistake. It can happen because of an infection, a medicine, or another disease. The cause is often unknown. Vasculitis can affect arteries, veins and capillaries. Arteries are vessels that carry blood from the heart to the body's organs. Veins are the vessels that carry blood back to the heart. Capillaries are tiny blood vessels that connect the small arteries and veins. When a blood vessel becomes inflamed, it can Narrow, making it more difficult for blood to get through Close off completely so that blood can't get through Stretch and weaken so much that it bulges. The bulge is called an aneurysm. If it bursts, it can cause dangerous bleeding inside the body. Symptoms of vasculitis can vary, but usually include fever, swelling and a general sense of feeling ill. The main goal of treatment is to stop the inflammation. Steroids and other medicines to stop inflammation are often helpful. NIH: National Heart, Lung, and Blood Institute

PubMed Health : 63 About vasculitis: Vasculitis (vas-kyu-LI-tis) is a condition that involves inflammation in the blood vessels. The condition occurs if your immune system attacks your blood vessels by mistake. This may happen as the result of an infection, a medicine, or another disease or condition.“Inflammation” refers to the body’s response to injury, including injury to the blood vessels. Inflammation may involve pain, redness, warmth, swelling, and loss of function in the affected tissues.In vasculitis, inflammation can lead to serious problems. Complications depend on which blood vessels, organs, or other body systems are affected.

Wikipedia : 76 Vasculitis is a group of disorders that destroy blood vessels by inflammation. Both arteries and veins... more...

Related Diseases for Vasculitis

Diseases in the Vasculitis family:

Autoimmune Vasculitis

Diseases related to Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 919)
# Related Disease Score Top Affiliating Genes
1 hypersensitivity vasculitis 34.1 CRP MEFV MPO PRTN3
2 lymphocytic vasculitis 34.0 ICAM1 SELE VCAM1
3 anca-associated vasculitis 34.0 MPO PRTN3 SERPINA1 TNF
4 rheumatoid vasculitis 33.9 CX3CL1 ICAM1 SELE TNF VCAM1
5 autoimmune vasculitis 33.5 CTSG ELANE
6 churg-strauss syndrome 33.0 MPO PRTN3 THBD TNF
7 temporal arteritis 32.7 APOH CRP TNF
8 microscopic polyangiitis 32.6 MPO TNF
9 kawasaki disease 32.5 CRP ELANE SELE TNF
10 granulomatosis with polyangiitis 32.3 BPI CTSG ELANE MPO PRTN3 SERPINA1
11 polyarteritis nodosa 32.3 APOH CRP MEFV MPO PRTN3 SELE
12 granulomatous angiitis 32.2 CRP PRTN3 THBD
13 alpha-1-antitrypsin deficiency 32.2 BPI ELANE SERPINA1
14 behcet syndrome 32.1 APOH CRP MEFV SELE THBD TNF
15 glomerulonephritis 30.8 CD40LG ICAM1 MPO PRTN3 VCAM1
16 purpura 30.6 APOH CRP THBD TNF VWF
17 systemic lupus erythematosus 30.6 APOH CD40LG CRP CTSG ELANE ICAM1
18 crescentic glomerulonephritis 30.5 BPI CTSG ICAM1 MPO VCAM1
19 henoch-schoenlein purpura 30.4 CRP ICAM1 MEFV MPO VCAM1
20 rapidly progressive glomerulonephritis 30.3 CRP ELANE ICAM1 MPO PRTN3
21 mononeuritis multiplex 30.3 CRP MPO
22 connective tissue disease 30.3 APOH CD40LG TNF TNFSF13B
23 rheumatoid arthritis 30.3 CD40LG CRP ICAM1 PRTN3 SELE TNF
24 endocarditis 30.2 APOH CRP TNF VCAM1
25 ulcerative colitis 30.2 BPI CRP MPO PRTN3 TNF
26 aortitis 30.2 CRP MPO
27 familial mediterranean fever 30.1 CRP MEFV TNF
28 pneumonia 30.1 CD40LG CRP ELANE MPO TNF
29 immune-complex glomerulonephritis 30.1 ICAM1 MPO VCAM1
30 cutaneous lupus erythematosus 30.1 ICAM1 SELE TNF
31 respiratory failure 30.1 CRP ELANE SERPINA1 TNF
32 autoimmune disease 30.0 APOH CD40LG TNF TNFSF13B
33 takayasu arteritis 30.0 CRP SELE THBD TNF VCAM1 VWF
34 pericarditis 30.0 CRP MEFV TNF
35 chorioamnionitis 30.0 CRP ELANE TNF
36 erysipelas 30.0 ELANE MEFV TNF
37 infective endocarditis 30.0 APOH CRP TNF
38 myocarditis 30.0 CD40LG ICAM1 TNF
39 arthus reaction 29.9 ELANE ICAM1 TNF
40 localized scleroderma 29.9 SELE TNF VCAM1
41 spotted fever 29.9 THBD TNF VWF
42 juvenile rheumatoid arthritis 29.9 CRP S100A9 TNF
43 reactive arthritis 29.9 BPI CRP TNF
44 stroke, ischemic 29.8 APOH CRP THBD VWF
45 thrombophilia due to thrombin defect 29.8 APOH THBD VWF
46 shwartzman phenomenon 29.8 ICAM1 TNF VCAM1
47 arteriosclerosis 29.8 CRP ICAM1 SELE VCAM1
48 adult-onset still's disease 29.8 CRP MEFV TNF
49 critical limb ischemia 29.8 SELE TNF
50 atherosclerosis susceptibility 29.8 CRP ICAM1 SELE TNF VCAM1

Graphical network of the top 20 diseases related to Vasculitis:



Diseases related to Vasculitis

Symptoms & Phenotypes for Vasculitis

UMLS symptoms related to Vasculitis:


angina pectoris, edema, chest pain

MGI Mouse Phenotypes related to Vasculitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.16 CD40LG CTSG CX3CL1 ELANE ICAM1 MEFV
2 cellular MP:0005384 10.1 CD40LG CX3CL1 ICAM1 MEFV PRTN3 S100A9
3 cardiovascular system MP:0005385 10.07 CD40LG CRP CX3CL1 ICAM1 MPO SELE
4 homeostasis/metabolism MP:0005376 10.03 APOH CD40LG CRP CX3CL1 ELANE ICAM1
5 immune system MP:0005387 9.89 CD40LG CRP CTSG CX3CL1 ELANE ICAM1
6 mortality/aging MP:0010768 9.47 APOH CD40LG CTSG ELANE ICAM1 MEFV

Drugs & Therapeutics for Vasculitis

PubMedHealth treatment related to Vasculitis: 63

Treatment for vasculitis will depend on the type of vasculitis you have, which organs are affected, and the severity of the condition.People who have severe vasculitis are treated with prescription medicines. Rarely, surgery may be done. People who have mild vasculitis may find relief with over-the-counter pain medicines, such as acetaminophen, aspirin, ibuprofen, or naproxen.The main goal of treating vasculitis is to reduce inflammation in the affected blood vessels. This usually is done by reducing or stopping the immune response that caused the inflammation.

Drugs for Vasculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 307)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
alemtuzumab Approved, Investigational Phase 4,Phase 2,Phase 1 216503-57-0
2
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-24-8 5755
4
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 302-25-0
5
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 2921-57-5
6
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 6055-19-2, 50-18-0 2907
7
Azathioprine Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 446-86-6 2265
8
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
9
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 4 67-73-2 6215
10
leucovorin Approved Phase 4,Phase 3,Phase 2,Not Applicable 58-05-9 6006 143
11
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 24280-93-1 446541
12
Methotrexate Approved Phase 4,Phase 3,Phase 2,Not Applicable 59-05-2, 1959-05-2 126941
13
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 22916-47-8 4189
14
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-78-2 2244
15
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 174722-31-7 10201696
16
Tacrolimus Approved, Investigational Phase 4,Phase 1 104987-11-3 445643 439492
17
Tazarotene Approved, Investigational Phase 4 118292-40-3 5381
18
Adalimumab Approved Phase 4,Phase 3 331731-18-1 16219006
19
Anthralin Approved Phase 4 1143-38-0
20
Colchicine Approved Phase 4,Phase 2 64-86-8 6167 2833
21
Sirolimus Approved, Investigational Phase 4 53123-88-9 46835353 6436030 5284616
22
Everolimus Approved Phase 4 159351-69-6 6442177
23
Heparin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 9005-49-6 772 46507594
24
Dalteparin Approved Phase 4,Phase 3,Phase 1,Phase 2 9005-49-6
25
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
26
Ibuprofen Approved Phase 4,Phase 3 15687-27-1 3672
27
Dapsone Approved, Investigational Phase 4,Phase 2 80-08-0 2955
28
Pravastatin Approved Phase 4,Phase 2 81093-37-0 54687
29
Tocopherol Approved, Investigational Phase 4 1406-66-2 14986
30
Ceftazidime Approved Phase 4 78439-06-2, 72558-82-8 5481173
31
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 59-30-3 6037
32
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
33
Prednisolone hemisuccinate Experimental Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 2920-86-7
34 Tocotrienol Investigational Phase 4 6829-55-6
35 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
36 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
37 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
38 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
39 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
40 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
41 Prednisolone acetate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
42 Neuroprotective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
43 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
44 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
45 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
46 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
47 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
48 Protective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
49 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
50 Methylprednisolone acetate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 491)
# Name Status NCT ID Phase Drugs
1 Alemtuzumab for ANCA Associated Refractory Vasculitis Unknown status NCT01405807 Phase 4 Alemtuzumab
2 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
3 The Efficacy of Methylprednisolone in the Treatment of Patients With Ocular Involvement in Behcet's Disease Unknown status NCT01306955 Phase 4 methylorednisolone
4 CHUSPAN PAN BP Treatment of Polyarteritis Nodosa and Microscopic Polyangiitis Without Poor-Prognosis Factors Unknown status NCT00400075 Phase 4 azathioprine;cyclophosphamide
5 CHUSPAN SCS BP Treatment of Churg–Strauss Syndrome Without Poor-Prognosis Factors Unknown status NCT00399399 Phase 4 azathioprine;cyclophosphamide
6 Steroids Pharmacokinetics and the Response to Prednisone Therapy in Giant Cell Arteritis Unknown status NCT01400464 Phase 4 Prednisone therapy and pharmacokinetic
7 Flucinolone Acetonide Implant for Treating Refractory Ocular Behcet's Disease Unknown status NCT00720928 Phase 4 flucinolone acetonide
8 Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years Completed NCT00307671 Phase 4 prednisone, methylprednisolone,cyclophosphamides;Cyclophosphamide, Azathioprine,prednisone,methylprednisolone;Mycophenolate mofetil,methotrexate
9 Pilot Study of Short-Course Glucocorticoids and Rituximab for Treatment of ANCA-Associated Vasculitis Completed NCT02169219 Phase 4 Glucocorticoids;Rituximab
10 Tacrolimus in Children With Henoch-Schönlein Purpura Nephritis Completed NCT03222687 Phase 4 tacrolimus;prednisone
11 Study of the Influence of Plasma Exchange on the Pharmacokinetics of Rituximab Completed NCT00820469 Phase 4 Rituximab 375;rituximab 1000
12 Effect of Adalimumab on Vascular Inflammation in Patients With Moderate to Severe Plaque Psoriasis Completed NCT00940862 Phase 4
13 The Comparison of the Efficacy of Once and Twice Daily Colchicine Dosage in Pediatric Patients With FMF Completed NCT02602028 Phase 4 colchicine
14 Study Of The Safety And Efficacy Of Conversion From A CNI To Sirolimus In Renally-Impaired Heart Transplant Recipients Completed NCT00369382 Phase 4 cyclosporine or tacrolimus;sirolimus
15 Short Term Efficacy of a Starting Dose of 12.5 mg of Prednisone in Polymyalgia Rheumatica Patients Completed NCT01169597 Phase 4 prednisone
16 A Study to Evaluate the Efficacy and Safety of Zenapax in Combination With CellCept, Cyclosporine, and Corticosteroids in Patients Undergoing Cardiac Transplantation Completed NCT00048165 Phase 4 Daclizumab;Methylprednisolone;Mycophenolate mofetil;Placebo;cyclosporine
17 Study of Combined Therapy of Aspirin and "IVIG-SN" in Kawasaki Disease Completed NCT01524939 Phase 4 immunoglobulin G
18 Efficacy of Low Molecular Weight Heparin in Superficial Vein Thrombosis Completed NCT01245998 Phase 4 Dalteparin;Dalteparin
19 Saline vs. Lactated Ringers for Emergency Department IV Fluid Resuscitation Completed NCT03133767 Phase 4 Lactated Ringer Solution;Normal Saline 0.9% Infusion Solution Bag
20 Efficacy and Safety of Esarin Gel in Chronic Venous Insufficiency and Varicose Veins Completed NCT02346058 Phase 4 Esarin Gel
21 HSP-glomerulonephritis Trial: MP vs CyA Completed NCT00425724 Phase 4 Methylprednisolone pulses plus prednisone versus Cyclosporine A
22 Topical Diclofenac Gel in Patients With Superficial Inflammation of the Veins Completed NCT00377806 Phase 4 Diclofenac gel
23 Management of Superficial Thrombophlebitis Completed NCT00264381 Phase 4 Dalteparin sodium injection
24 Maintenance of ANCA Vasculitis Remission by Intermittent Rituximab Dosing Recruiting NCT02749292 Phase 4 Rituximab
25 Low-dose Glucocorticoid Vasculitis Induction Study Recruiting NCT02198248 Phase 4 Rituximab;Glucocorticoids
26 Maintenance of Remission With Rituximab Versus Azathioprine for Newly-diagnosed or Relapsing Eosinophilic Granulomatosis With Polyangiitis. Recruiting NCT03164473 Phase 4 Rituximab;Azathioprine;Placebo-rituximab;Placebo-azathioprine
27 Clinical Utility Of Genetic Screening For HLA-B*1301, On Susceptibility To Dapsone Hypersensitivity Syndrome Recruiting NCT02550080 Phase 4 Dapsone
28 Tocilizumab Plus a Short Prednisone Taper for GCA Recruiting NCT03726749 Phase 4 Tocilizumab;Prednisone
29 Tocilizumab Dose-tapering and Interruption in Patients With Giant Cell Arteritis Achieving the Clinical Remission. Recruiting NCT03244709 Phase 4 Tocilizumab
30 Efficacy and Safety of H.P. ACTHAR GEL in Adults With Retinal Vasculitis Active, not recruiting NCT03066869 Phase 4 H.P. ACTHAR GEL
31 Combined Pneumococcal Conjugate and Polysaccharide Vaccination in Inflammatory Rheumatic Disease Active, not recruiting NCT03762824 Phase 4
32 The Impact of Neut During Potassium Chloride Replacement on Pain and Incidence of Phlebitis Enrolling by invitation NCT02082717 Phase 4 potassium chloride replacement;Experimental - 4% Sodium Bicarbonate
33 A Study Evaluating the Safety and Efficacy of Rituximab in Combination With Glucocorticoids in Participants With Wegener's Granulomatosis or Microscopic Polyangitis Suspended NCT02115997 Phase 4 Methylprednisolone;Prednisone;Rituximab
34 Normal Saline Versus Heparinized Solution Flush for Maintaining Patency of Peripheral Venous Catheters in Children Suspended NCT01794767 Phase 4 0,9% NaCl flush;Heparin 50U/ml
35 Prevention of Relapses in Proteinase 3 (PR3)-Anti-neutrophil Cytoplasmic Antibodies (ANCA)-Associated Vasculitis Terminated NCT00128895 Phase 4 azathioprine
36 Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein Levels Terminated NCT00578578 Phase 4
37 Anti-Oxidant Therapy In Chronic Renal Insufficiency (ATIC) Study Terminated NCT00384618 Phase 4 pravastatin;vitamin E
38 Rituximab for the Otolaryngologic Manifestations of Granulomatosis With Polyangiitis Terminated NCT02626845 Phase 4 Rituximab
39 Interventional Cryotherapy for the Eradication of Benign Airway Disease ("ICE the BAD") Terminated NCT00747461 Phase 4
40 Cacicol20® in Corneal Wound Healing and Nerve Regeneration After Phototherapeutic Keratectomy Terminated NCT02373397 Phase 4
41 Prolonging the Duration of Peripheral Venous Catheters in Cystic Fibrosis People Terminated NCT00418470 Phase 4
42 WEGENT - Comparison of Methotrexate or Azathioprine as Maintenance Therapy for ANCA-Associated Vasculitides Unknown status NCT00349674 Phase 3 Azathioprine: 2 mg/kg/day;methotrexate 0.3 mg/kg/week, to a maximum and optimal dose of 25 mg/week
43 Mycophenolate Mofetil for Treatment of Relapses of Wegener's Disease or Microscopic Polyangiitis (MPA) Unknown status NCT00103792 Phase 3 mycophenolate mofetil;cyclophosphamide
44 Pain and Music Therapy in Patients Suffering Arteritis Unknown status NCT01323504 Phase 3
45 Efficacy and Safety of E-101 Solution for Preventing Surgical Site Infections After Colorectal Surgery Unknown status NCT01297959 Phase 3 E-101 Solution 300 GU/ml;Saline solution
46 Peripheral Venous Catheter Trial: 3 Day Versus No Routine Change Unknown status NCT00103636 Phase 2, Phase 3
47 Infliximab Therapy in Patients With Refractory Polymyalgia Rheumatica Unknown status NCT01423591 Phase 3 infliximab;inactive powder
48 Clinical Trial of Mycophenolate Versus Cyclophosphamide in ANCA Vasculitis Completed NCT00414128 Phase 2, Phase 3 mycophenolate mofetil;cyclophosphamide
49 Pulse Versus Continuous Cyclophosphamide for Induction of Remission in ANCA-Associated Vasculitides Completed NCT00430105 Phase 2, Phase 3 cyclophosphamide
50 Efficacy Study of Two Treatments in the Remission of Vasculitis Completed NCT00748644 Phase 3 Rituximab;Azathioprine

Search NIH Clinical Center for Vasculitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: vasculitis

Genetic Tests for Vasculitis

Genetic tests related to Vasculitis:

# Genetic test Affiliating Genes
1 Vasculitis 29

Anatomical Context for Vasculitis

MalaCards organs/tissues related to Vasculitis:

41
Neutrophil, Endothelial, Skin, T Cells, Lung, Kidney, B Cells

Publications for Vasculitis

Articles related to Vasculitis:

(show top 50) (show all 4530)
# Title Authors Year
1
Immunoglobulin A Nephropathy and Immunoglobulin A Vasculitis. ( 30454736 )
2019
2
Vasculitis and peripheral neuropathy. ( 30461543 )
2019
3
The role of complement in antineutrophil cytoplasmic antibody-associated vasculitis. ( 30461541 )
2019
4
Management of large-vessel vasculitis. ( 30461542 )
2019
5
Renal relapse in antineutrophil cytoplasmic autoantibody-associated vasculitis: unpredictable, but predictive of renal outcome. ( 30551161 )
2019
6
Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in Korea: A Narrative Review. ( 30554486 )
2019
7
An update on the nomenclature for cutaneous vasculitis. ( 30394939 )
2019
8
Remote arterial vasculitis as a possible complication of Phosphorus-32 Radiosynovectomy. ( 30405863 )
2019
9
Editorial: A review of vasculitis 2019: an introduction. ( 30407227 )
2019
10
Anti-tubulin-I+-1C autoantibody in systemic lupus erythematosus: a novel indicator of disease activity and vasculitis manifestations. ( 29427009 )
2018
11
Cerebrospinal Fluid Findings in Reversible Cerebral Vasoconstriction Syndrome - A way to differentiate from Cerebral Vasculitis? ( 29722896 )
2018
12
Matrix Metalloprotease-9 (MMP-9)-Producing Monocytes Enable T Cells to Invade the Vessel Wall and Cause Vasculitis. ( 29970365 )
2018
13
Diffuse Alveolar Hemorrhage in IgA Vasculitis with an Atypical Presentation. ( 29033424 )
2018
14
Primary central nervous system vasculitis associated with lymphoma. ( 29429967 )
2018
15
Primary central nervous system vasculitis mimicking a brain tumor on conventional magnetic resonance imaging: the usefulness of perfusion-weighted imaging. A case report. ( 29516404 )
2018
16
Retinal vasculitis and Eales disease. ( 29599058 )
2018
17
Acute respiratory distress syndrome in a man with Epstein-Barr virus infection-induced hypocomplementemic urticarial vasculitis. ( 29458992 )
2018
18
An Autopsy Case of Myeloperoxidase-anti-neutrophil Cytoplasmic Antibody (MPO-ANCA) -associated Vasculitis Accompanied by Cryoglobulinemic Vasculitis Affecting the Kidneys, Skin, and Gastrointestinal Tract. ( 29709950 )
2018
19
The adenosinergic system: a potential player in the pathogenesis of ANCA-associated vasculitis? ( 29745882 )
2018
20
Red Blood Cell Distribution Width Can Predict Vasculitis Activity and Poor Prognosis in Granulomatosis with Polyangiitis. ( 29436199 )
2018
21
Efficacy of adalimumab and infliximab in recalcitrant retinal vasculitis inadequately responsive to other immunomodulatory therapies. ( 29766375 )
2018
22
Letter to the Editor: Time for cost-effectiveness studies for preventive strategies applied according to risk of cytomegalovirus-related morbidity and mortality in ANCA-associated vasculitis. ( 29663157 )
2018
23
18F-Fluorodeoxyglucose Positron Emission Tomography-computed Tomography in Evaluation of Large Vessel Vasculitis. ( 29430115 )
2018
24
Evaluation of efficacy of infliximab for retinal vasculitis and extraocular symptoms in BehAset disease. ( 29582190 )
2018
25
Isolated Cervical Cord Involvement in Primary Central Nervous System Vasculitis. ( 29961677 )
2018
26
Adult onset immunoglobulin A vasculitis (Henoch-Schonlein purpura) with alveolar hemorrhage. ( 29942747 )
2018
27
Propylthiouracil-induced ANCA-negative cutaneous small vessel vasculitis. ( 29441165 )
2018
28
Anti-neutrophil extracellular trap antibody in a patient with relapse of anti-neutrophil cytoplasmic antibody-associated vasculitis: a case report. ( 29929470 )
2018
29
Retinal Vasculitis in Takayasu's Arteritis. ( 29791818 )
2018
30
Leukocytoclastic Vasculitis (Hypersensitivity Vasculitis) ( 29489227 )
2018
31
Comparing immunoglobulin A vasculitis (Henoch-SchAPnlein purpura) in children and adults: a single-centre study from Turkey. ( 29912602 )
2018
32
Psychiatric and functional neuroimaging abnormalities in chronic hepatitis C virus patients: Is vasculitis a contributing factor? ( 29935864 )
2018
33
Multimodal imaging questions etiology of idiopathic retinal vasculitis, aneurysms and neuroretinitis syndrome (IRVAN syndrome). ( 29406987 )
2018
34
The treatment outcomes of rituximab for intractable otitis media with ANCA-associated vasculitis. ( 29885746 )
2018
35
Ipilimumab induced digital vasculitis. ( 29433584 )
2018
36
Rituximab for Sight-Threatening Lupus-Related Retinal Vasculitis. ( 29059086 )
2018
37
Excessive neutrophil extracellular trap formation in ANCA-associated vasculitis is independent of ANCA. ( 29606398 )
2018
38
Linked help from bacterial proteins drives autoantibody production in small vessel vasculitis. ( 29447930 )
2018
39
The first case of bacillus Calmette-GuAcrin-induced small-vessel central nervous system vasculitis. ( 29740727 )
2018
40
Renal-limited Cryoglobulinemic Vasculitis: Two Case Reports. ( 29962417 )
2018
41
Myeloperoxidase-ANCA-positive granulomatosis with polyangiitis is a distinct subset of ANCA-associated vasculitis: A retrospective analysis of 455 patients from a single center in China. ( 29887327 )
2018
42
Hemorrhagic Ischemic Retinal Vasculitis and Alopecia Areata as a Manifestation of HLA-B27. ( 29304269 )
2018
43
Vasculitis or coronary atherosclerosis? Optical coherence tomography images in polyarteritis nodosa. ( 29652433 )
2018
44
Sweet's Syndrome Mimicking ANCA-Associated Vasculitis. ( 29355513 )
2018
45
Staphylococcus-Associated Glomerulonephritis Mimicking Henoch-SchAPnlein Purpura and Cryoglobulinemic Vasculitis in a Patient With an Epidural Abscess: A Case Report and Brief Review of the Literature. ( 29900000 )
2018
46
PR3-ANCA: a potential biomarker of disease activity for propylthiouracil-induced ANCA-associated vasculitis. ( 29888703 )
2018
47
Cocaine and ANCA associated vasculitis-like syndromes - A case series. ( 29108823 )
2018
48
On hepatitis B virus and vasculitis. ( 29948001 )
2018
49
MicroRNA-145-5p and microRNA-320a encapsulated in endothelial microparticles contribute to the progression of vasculitis in acute Kawasaki Disease. ( 29343815 )
2018
50
Correction to: Voriconazole-induced periostitis deformans: serial imaging in a patient with ANCA vasculitis. ( 29353405 )
2018

Variations for Vasculitis

ClinVar genetic disease variations for Vasculitis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CCM2 NM_031443.3(CCM2): c.1234C> T (p.Arg412Trp) single nucleotide variant Uncertain significance rs544276945 GRCh37 Chromosome 7, 45115555: 45115555
2 CCM2 NM_031443.3(CCM2): c.1234C> T (p.Arg412Trp) single nucleotide variant Uncertain significance rs544276945 GRCh38 Chromosome 7, 45075956: 45075956
3 COL4A2 NM_001846.3(COL4A2): c.1776+13A> G single nucleotide variant Uncertain significance GRCh37 Chromosome 13, 111114744: 111114744
4 COL4A2 NM_001846.3(COL4A2): c.1776+13A> G single nucleotide variant Uncertain significance GRCh38 Chromosome 13, 110462397: 110462397

Expression for Vasculitis

Search GEO for disease gene expression data for Vasculitis.

Pathways for Vasculitis

Pathways related to Vasculitis according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.24 CD40LG ICAM1 PRTN3 TNF TNFSF13B VCAM1
2
Show member pathways
13.12 BPI CD40LG CRP CTSG ELANE ICAM1
3 12.42 CD40LG MPO TNF TNFSF13B VCAM1
4
Show member pathways
12.25 BPI CTSG ELANE PRTN3 S100A9
5
Show member pathways
12.19 CRP ICAM1 MPO TNF
6 12.02 ICAM1 SELE THBD TNF VCAM1
7 11.98 CD40LG ICAM1 SELE VCAM1
8 11.87 CX3CL1 ICAM1 SELE TNF VCAM1
9
Show member pathways
11.78 CTSG ELANE TNF
10 11.76 CTSG SERPINB1 TNF
11 11.76 ICAM1 SELE THBD TNF VCAM1
12 11.72 ICAM1 TNF TNFSF13B
13 11.7 CD40LG ICAM1 TNF TNFSF13B VCAM1
14 11.64 ELANE MPO PRTN3
15
Show member pathways
11.61 CD40LG TNF TNFSF13B
16
Show member pathways
11.45 CD40LG ICAM1 SELE TNF VCAM1
17 11.44 ELANE ICAM1 MPO TNF
18 11.37 ICAM1 SELE VCAM1
19 11.25 ICAM1 SELE TNF VCAM1
20 11.08 CD40LG CX3CL1 TNF TNFSF13B
21 11.04 CD40LG ICAM1 SELE TNF VCAM1
22 10.66 ICAM1 MPO TNF VCAM1

GO Terms for Vasculitis

Cellular components related to Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.91 APOH CD40LG CTSG CX3CL1 ELANE ICAM1
2 azurophil granule lumen GO:0035578 9.77 BPI CTSG ELANE MPO PRTN3
3 membrane raft GO:0045121 9.71 ICAM1 PRTN3 SELE TNF
4 secretory granule GO:0030141 9.61 CTSG ELANE MPO
5 collagen-containing extracellular matrix GO:0062023 9.61 APOH CTSG ELANE ICAM1 PRTN3 S100A9
6 extracellular space GO:0005615 9.58 APOH BPI CD40LG CRP CTSG CX3CL1
7 extracellular exosome GO:0070062 10.1 APOH BPI CTSG ELANE ICAM1 MPO
8 extracellular region GO:0005576 10.03 APOH BPI CD40LG CRP CTSG CX3CL1

Biological processes related to Vasculitis according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.98 CD40LG CRP CX3CL1 MEFV S100A9 SELE
2 regulation of immune response GO:0050776 9.94 CD40LG ICAM1 TNFSF13B VCAM1
3 extracellular matrix organization GO:0030198 9.93 ICAM1 TNF VCAM1 VWF
4 cytokine-mediated signaling pathway GO:0019221 9.93 CX3CL1 ICAM1 PRTN3 TNF VCAM1
5 defense response to bacterium GO:0042742 9.93 BPI CTSG ELANE MPO S100A9 TNF
6 leukocyte migration GO:0050900 9.92 ELANE ICAM1 SELE TNF
7 neutrophil degranulation GO:0043312 9.92 BPI CTSG ELANE MPO PRTN3 S100A9
8 blood coagulation GO:0007596 9.91 PRTN3 SERPINA1 THBD VWF
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 CD40LG CX3CL1 ICAM1 S100A9 TNF
10 defense response to Gram-positive bacterium GO:0050830 9.85 CRP CTSG TNF
11 positive regulation of inflammatory response GO:0050729 9.85 CX3CL1 S100A9 TNF
12 regulation of inflammatory response GO:0050727 9.82 S100A9 SELE TNF
13 tumor necrosis factor-mediated signaling pathway GO:0033209 9.82 CD40LG TNF TNFSF13B
14 positive regulation of T cell proliferation GO:0042102 9.8 CD40LG TNFSF13B VCAM1
15 positive regulation of smooth muscle cell proliferation GO:0048661 9.78 CX3CL1 ELANE TNF
16 hemostasis GO:0007599 9.77 SERPINA1 THBD VWF
17 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.74 ICAM1 SELE VCAM1
18 defense response to fungus GO:0050832 9.71 CTSG ELANE MPO S100A9
19 negative regulation of interleukin-6 production GO:0032715 9.69 BPI CX3CL1 TNF
20 negative regulation of blood coagulation GO:0030195 9.68 APOH THBD
21 negative regulation of fibrinolysis GO:0051918 9.67 APOH THBD
22 leukocyte tethering or rolling GO:0050901 9.67 SELE TNF VCAM1
23 leukocyte cell-cell adhesion GO:0007159 9.67 CD40LG ICAM1 SELE VCAM1
24 negative regulation of interleukin-1 beta production GO:0032691 9.66 CX3CL1 MEFV
25 positive regulation of immune response GO:0050778 9.66 CTSG ELANE
26 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.65 ELANE TNF
27 negative regulation of lipid storage GO:0010888 9.65 CRP TNF
28 antimicrobial humoral response GO:0019730 9.65 BPI CTSG ELANE PRTN3 S100A9
29 acute inflammatory response to antigenic stimulus GO:0002438 9.63 ELANE ICAM1
30 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.59 ICAM1 TNF
31 membrane to membrane docking GO:0022614 9.58 ICAM1 VCAM1
32 regulation of immunoglobulin secretion GO:0051023 9.58 CD40LG TNF
33 immunoglobulin secretion GO:0048305 9.56 CD40LG TNFSF13B
34 response to yeast GO:0001878 9.55 ELANE MPO
35 negative regulation of growth of symbiont in host GO:0044130 9.46 CTSG ELANE MPO TNF
36 leukocyte migration involved in inflammatory response GO:0002523 9.26 CX3CL1 ELANE S100A9 SELE
37 response to lipopolysaccharide GO:0032496 9.17 CTSG ELANE ICAM1 MPO SELE THBD
38 immune response GO:0006955 10 BPI CD40LG CTSG CX3CL1 TNF TNFSF13B

Molecular functions related to Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.62 CD40LG CX3CL1 TNF TNFSF13B
2 heparin binding GO:0008201 9.56 APOH CTSG ELANE MPO
3 integrin binding GO:0005178 9.46 CX3CL1 ICAM1 VCAM1 VWF
4 tumor necrosis factor receptor binding GO:0005164 9.13 CD40LG TNF TNFSF13B
5 protease binding GO:0002020 8.92 ELANE SERPINA1 TNF VWF

Sources for Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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