MCID: VSC004
MIFTS: 34

Vasculogenic Impotence

Categories: Cardiovascular diseases, Mental diseases

Aliases & Classifications for Vasculogenic Impotence

MalaCards integrated aliases for Vasculogenic Impotence:

Name: Vasculogenic Impotence 12 15 17
Impotence, Vasculogenic 45 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4762
MeSH 45 D018783
UMLS 74 C0243000

Summaries for Vasculogenic Impotence

MalaCards based summary : Vasculogenic Impotence, also known as impotence, vasculogenic, is related to impotence and priapism. An important gene associated with Vasculogenic Impotence is SYNE2 (Spectrin Repeat Containing Nuclear Envelope Protein 2), and among its related pathways/superpathways are Arginine and proline metabolism and Nitric oxide stimulates guanylate cyclase. The drugs Sirolimus and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include testes, endothelial and kidney, and related phenotypes are cardiovascular system and muscle

Related Diseases for Vasculogenic Impotence

Diseases related to Vasculogenic Impotence via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 impotence 31.5 ALDH7A1 NOS3 PDE5A
2 priapism 30.3 NOS3 PDE5A
3 hypoaldosteronism 10.3 ACE NPPA
4 anterolateral myocardial infarction 10.3 ACE NPPA
5 syndrome of inappropriate antidiuretic hormone 10.3 ACE NPPA
6 malignant hypertension 10.2 ACE NPPA
7 psychosexual disorder 10.2 ALDH7A1 PDE5A
8 idiopathic edema 10.2 ACE NPPA
9 hepatorenal syndrome 10.2 ACE NPPA
10 mitral valve insufficiency 10.2 ACE NPPA
11 renal artery disease 10.2 ACE NOS3
12 left bundle branch hemiblock 10.2 ACE PTS
13 penile disease 10.2 NOS3 PDE5A
14 central sleep apnea 10.2 NOS3 NPPA
15 aortic coarctation 10.2 ACE NOS3
16 transient global amnesia 10.2 ALDH7A1 PDE5A
17 pulmonary hypertension, primary, 1 10.2 NPPA PDE5A
18 corneal dystrophy, reis-bucklers type 10.1 ALDH7A1 PDE4A
19 ischemic heart disease 10.1 ACE NOS3
20 persistent fetal circulation syndrome 10.1 NOS3 PDE5A
21 pure autonomic failure 10.1 ACE NPPA PDE5A
22 neuroretinitis 10.1 ACE RNASE3
23 jejunoileitis 10.1 ALDH7A1 NOS3
24 angina pectoris 10.1 ACE NOS3
25 acute mountain sickness 10.1 ACE NOS3
26 heart valve disease 10.0 ACE NPPA
27 peripheral artery disease 10.0 ACE NOS3
28 tetrahydrobiopterin deficiency 10.0 NOS3 PTS
29 arteritic anterior ischemic optic neuropathy 10.0 ACE NOS3 PDE5A
30 ischemic optic neuropathy 10.0 ACE NOS3 PDE5A
31 limb ischemia 10.0 ACE NOS3
32 nonarteritic anterior ischemic optic neuropathy 10.0 ACE NOS3 PDE5A
33 pulmonary eosinophilia 10.0 PDE4A RNASE3
34 diastolic heart failure 10.0 ACE NOS3 NPPA
35 renovascular hypertension 10.0 ACE NOS3 NPPA
36 mitral valve disease 10.0 ACE NOS3 NPPA
37 pulmonary edema 10.0 ACE NOS3 NPPA
38 coronary artery anomaly 10.0 ACE NOS3 NPPA
39 chronic kidney failure 10.0 ACE NOS3 NPPA
40 aortic valve disease 2 9.9 ACE NPPA
41 hypertension, essential 9.9 ACE NOS3 NPPA
42 respiratory allergy 9.8 NOS3 RNASE3
43 bronchial disease 9.8 PDE4A RNASE3
44 myocardial infarction 9.8 ACE NOS3 NPPA PDE5A
45 heart disease 9.8 ACE NOS3 NPPA PDE5A
46 ischemia 9.7 ACE CAV1 NOS3
47 sexual disorder 9.5 ACE ALDH7A1 NOS3 PDE4A PDE5A
48 pulmonary hypertension 9.3 ACE CAV1 NOS3 NPPA PDE5A

Graphical network of the top 20 diseases related to Vasculogenic Impotence:



Diseases related to Vasculogenic Impotence

Symptoms & Phenotypes for Vasculogenic Impotence

MGI Mouse Phenotypes related to Vasculogenic Impotence:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.5 ACE CAV1 NOS3 NPPA PDE4A PTS
2 muscle MP:0005369 9.02 CAV1 NOS3 NPPA PTS SYNE2

Drugs & Therapeutics for Vasculogenic Impotence

Drugs for Vasculogenic Impotence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sirolimus Approved, Investigational Phase 2, Phase 3 53123-88-9 46835353 5284616 6436030
2
Everolimus Approved Phase 2, Phase 3 159351-69-6 70789204 6442177
3
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
4 Immunosuppressive Agents Phase 2, Phase 3
5 Anti-Infective Agents Phase 2, Phase 3
6 Anti-Bacterial Agents Phase 2, Phase 3
7 Immunologic Factors Phase 2, Phase 3
8 Antibiotics, Antitubercular Phase 2, Phase 3
9 Antifungal Agents Phase 2, Phase 3
10
Coal tar Approved Phase 1, Phase 2 8007-45-2
11 Anesthetics Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Bioabsorbable Everolimus-Eluting Stents for Internal Pudendal Artery-Related Arteriogenic Erectile Dysfunction Unknown status NCT02492386 Phase 2, Phase 3
2 Effectiveness and Safety of Adipose-Derived Regenerative Cells for Treatment of Erectile Dysfunction Completed NCT02472431 Phase 1, Phase 2

Search NIH Clinical Center for Vasculogenic Impotence

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: impotence, vasculogenic

Genetic Tests for Vasculogenic Impotence

Anatomical Context for Vasculogenic Impotence

MalaCards organs/tissues related to Vasculogenic Impotence:

42
Testes, Endothelial, Kidney

Publications for Vasculogenic Impotence

Articles related to Vasculogenic Impotence:

(show top 50) (show all 85)
# Title Authors Year
1
The role of Doppler ultrasound in the diagnosis of vasculogenic impotence. ( 21341552 )
2010
2
Vasculogenic impotence as a symptom in late-onset Buerger's disease. ( 17486572 )
2007
3
Corpus cavernosum from men with vasculogenic impotence is partially resistant to adenosine relaxation due to endothelial A(2B) receptor dysfunction. ( 16837560 )
2006
4
Vasculogenic impotence. Arterial and venous surgery. ( 11402583 )
2001
5
Vasculogenic impotence and cavernosal oxygen tension. ( 10982308 )
2000
6
Vasculogenic impotence and cavernosal oxygen tension. ( 11052643 )
2000
7
Recent advancement in diagnosis of vasculogenic impotence. ( 11225903 )
1999
8
Technetium-99m-labelled RBC erection penogram to differentiate psychogenic from vasculogenic impotence. ( 9792979 )
1998
9
Laparoscopic mobilization of the inferior epigastric artery for penile revascularization in vasculogenic impotence. ( 9250921 )
1997
10
Intracavernosal forskolin: role in management of vasculogenic impotence resistant to standard 3-agent pharmacotherapy. ( 9334594 )
1997
11
Laparoscopically assisted penile revascularization for vasculogenic impotence: 2 additional cases. ( 9334601 )
1997
12
A randomized crossover study using yohimbine and isoxsuprine versus pentoxifylline in the management of vasculogenic impotence. ( 7490815 )
1996
13
Dynamic infusion cavernosometry and cavernosography (DICC) in the evaluation of vasculogenic impotence. ( 8705878 )
1996
14
Correlation of ultrastructural alterations in cavernous tissue with the clinical diagnosis vasculogenic impotence. ( 8840493 )
1996
15
An attempt to standardize the pharmacological diagnostic screening of vasculogenic impotence with prostaglandin E1. ( 7496445 )
1995
16
Laparoscopically assisted penile revascularization for vasculogenic impotence. ( 7752356 )
1995
17
The use of duplex ultrasound in the assessment of arterial supply to the penis in vasculogenic impotence. ( 7815582 )
1995
18
Diagnosis and treatment of vasculogenic impotence. ( 7618374 )
1994
19
Effectiveness and safety of multidrug intracavernous therapy for vasculogenic impotence. ( 7694416 )
1993
20
Effect of multidose intracorporeal injection and audiovisual sexual stimulation in vasculogenic impotence. ( 8256402 )
1993
21
Evaluation of vasculogenic impotence by monitoring of cavernous oxygen tension. ( 8479014 )
1993
22
Deep dorsal vein arterialization in vasculogenic impotence: our experience. ( 1462154 )
1992
23
Microsurgical arteriovenous revascularization in the treatment of vasculogenic impotence. ( 1532427 )
1992
24
High-flow priapism and glans hypervascularization following deep dorsal vein arterialization for vasculogenic impotence. ( 1475866 )
1992
25
Re: Diagnostic value of the radioisotope erection penogram for vasculogenic impotence. ( 1729525 )
1992
26
Dual radioisotopic study: a technique for the evaluation of vasculogenic impotence. ( 1729549 )
1992
27
The role of colour duplex ultrasonography in the diagnosis of vasculogenic impotence. ( 1747732 )
1991
28
Angiodynography (color-coded duplex sonography) in the evaluation of vasculogenic impotence. ( 1792709 )
1991
29
Arterial and venous surgery for vasculogenic impotence: a combined French and American experience. ( 1830422 )
1991
30
Cigarette smoking and other vascular risk factors in vasculogenic impotence. ( 1887536 )
1991
31
Aorto-iliac/femoral reconstructions in patients with vasculogenic impotence. ( 1915908 )
1991
32
Vascular surgery for vasculogenic impotence. ( 1943935 )
1991
33
Vasculogenic impotence. Duplex and color Doppler imaging. ( 2024011 )
1991
34
Double-blind, cross-over study comparing prostaglandin E1 and papaverine in patients with vasculogenic impotence. ( 2038782 )
1991
35
Re: Diagnostic value of the radioisotope erection penogram for vasculogenic impotence. ( 2056583 )
1991
36
Evaluation of vasculogenic impotence using dynamic penile washout test. ( 1982133 )
1990
37
Diagnostic value of the radioisotope erection penogram for vasculogenic impotence. ( 2169002 )
1990
38
Cavernous vein arterialization for vasculogenic impotence. An animal model. ( 2353378 )
1990
39
Duplex and color Doppler sonographic evaluation of vasculogenic impotence. ( 2683672 )
1989
40
Re: Duplex scanning in suspected vasculogenic impotence: a worthwhile exercise? ( 2684338 )
1989
41
The assessment of pelvic circulation after internal iliac arterial reconstruction: a retrospective study of the treatment for vasculogenic impotence and hip claudication. ( 2687527 )
1989
42
Diagnosis of vasculogenic impotence: combination of penile xenon-133 washout and papaverine tests. ( 2749953 )
1989
43
Algorithm for the delineation and treatment of vasculogenic impotence. A review. ( 2651349 )
1989
44
Duplex scanning in suspected vasculogenic impotence: a worthwhile exercise? ( 2653560 )
1989
45
Vasculogenic impotence. ( 2708012 )
1989
46
The noninvasive diagnosis of vasculogenic impotence. ( 3373624 )
1988
47
Analysis of the results of reconstructive surgery for vasculogenic impotence. ( 3397717 )
1988
48
Re: Reconstructive surgery for vasculogenic impotence. ( 3398150 )
1988
49
Diagnosis of vasculogenic impotence. Comparing investigations by Doppler sonography and angiography. ( 3041769 )
1988
50
Evaluation of vasculogenic impotence. ( 3278477 )
1988

Variations for Vasculogenic Impotence

Expression for Vasculogenic Impotence

Search GEO for disease gene expression data for Vasculogenic Impotence.

Pathways for Vasculogenic Impotence

Pathways related to Vasculogenic Impotence according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.91 ALDH7A1 NOS3
2
Show member pathways
10.58 NOS3 PDE5A
3 9.74 NOS3 PDE5A

GO Terms for Vasculogenic Impotence

Biological processes related to Vasculogenic Impotence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood vessel remodeling GO:0001974 9.4 ACE NOS3
2 posttranscriptional regulation of gene expression GO:0010608 9.37 ACE CAV1
3 regulation of nitric-oxide synthase activity GO:0050999 9.32 CAV1 NOS3
4 regulation of blood vessel size GO:0050880 9.26 NOS3 NPPA
5 cofactor metabolic process GO:0051186 9.16 NOS3 PTS
6 regulation of blood pressure GO:0008217 9.13 ACE NOS3 NPPA
7 regulation of the force of heart contraction by chemical signal GO:0003057 8.62 CAV1 NOS3

Molecular functions related to Vasculogenic Impotence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphoric diester hydrolase activity GO:0008081 8.62 PDE4A PDE5A

Sources for Vasculogenic Impotence

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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