MCID: VSM001
MIFTS: 35

Vasomotor Rhinitis

Categories: Respiratory diseases

Aliases & Classifications for Vasomotor Rhinitis

MalaCards integrated aliases for Vasomotor Rhinitis:

Name: Vasomotor Rhinitis 12 15 17
Rhinitis, Vasomotor 45 74
Rhinitis Vasomotor 56

Classifications:



External Ids:

Disease Ontology 12 DOID:4730
MeSH 45 D012223
NCIt 51 C34988
SNOMED-CT 69 8229003
ICD10 34 J30.0
UMLS 74 C0035460

Summaries for Vasomotor Rhinitis

Disease Ontology : 12 A rhinitis which involves a hypersensitive reaction to various potentially irritating stimuli such as changes in weather, temperature, or barometric pressure, chemical irritants such as smoke, ozone, pollution, perfumes, and aerosol sprays, psychological stress and emotional shocks, medications, alcohol, and spicy food.

MalaCards based summary : Vasomotor Rhinitis, also known as rhinitis, vasomotor, is related to rhinitis and irritable bowel syndrome. An important gene associated with Vasomotor Rhinitis is VIP (Vasoactive Intestinal Peptide), and among its related pathways/superpathways is G alpha (s) signalling events. The drugs Azelastine and Histamine have been mentioned in the context of this disorder.

Related Diseases for Vasomotor Rhinitis

Diseases related to Vasomotor Rhinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 rhinitis 31.7 RNASE3 VIP
2 irritable bowel syndrome 30.1 TAC1 VIP
3 asthma 29.3 CD40LG IL16 RNASE3 TAC1 VIP
4 allergic rhinitis 10.5
5 pollen allergy 10.3
6 anismus 10.2 TAC1 VIP
7 wdha syndrome 10.2 CALCA VIP
8 leprosy 2 10.2 CALCA VIP
9 cluster headache 10.2 CALCA VIP
10 pancreatic cholera 10.2 CALCA VIP
11 burn scar 10.2 CALCA TAC1
12 somatostatinoma 10.2 CALCA VIP
13 anxiety 10.1
14 islet cell tumor 10.1 CALCA VIP
15 retinitis pigmentosa 68 10.1 NPS TAC1
16 epicondylitis 10.1 NPS TAC1
17 brachial plexus lesion 10.1 CALCA TAC1
18 persian gulf syndrome 10.1 NPS VIP
19 dental pulp disease 10.1 NPS TAC1
20 complex regional pain syndrome 10.1 CALCA TAC1
21 reflex sympathetic dystrophy 10.1 CALCA NPS
22 indeterminate leprosy 10.1 NPS TAC1
23 neurodermatitis 10.1 NPS TAC1
24 cloacogenic carcinoma 10.1 CALCA NPS
25 holoprosencephaly 3 10.1 NPS VIP
26 hemiplegia 10.1 CALCA TAC1
27 alternating hemiplegia of childhood 10.1 CALCA TAC1
28 perry syndrome 10.0 NPS TAC1
29 meningoencephalitis 10.0 CD40LG TAC1
30 gastroesophageal reflux 10.0
31 ige responsiveness, atopic 10.0
32 meniere disease 10.0
33 sinusitis 10.0
34 hyperinsulinism 10.0
35 atrophic rhinitis 10.0
36 diffuse pulmonary fibrosis 10.0 CALCA TAC1 VIP
37 constipation 10.0 CALCA TAC1 VIP
38 prurigo nodularis 10.0 RNASE3 TAC1
39 autonomic nervous system disease 9.9 CALCA NPS TAC1
40 causalgia 9.9 CALCA NPS TAC1
41 cryptosporidiosis 9.9 CD40LG TAC1 VIP
42 upper respiratory tract disease 9.8 RNASE3 TAC1
43 endocrine gland cancer 9.8 CALCA VIP
44 bronchial disease 9.8 RNASE3 TAC1
45 bronchitis 9.8 RNASE3 TAC1 VIP
46 migraine with or without aura 1 9.7 CALCA NPS TAC1 VIP
47 nasal cavity disease 9.7 NPS RNASE3 TAC1
48 nose disease 9.7 NPS RNASE3 TAC1
49 schistosomiasis 9.6 CD40LG RNASE3
50 allergic asthma 9.6 IL16 RNASE3

Graphical network of the top 20 diseases related to Vasomotor Rhinitis:



Diseases related to Vasomotor Rhinitis

Symptoms & Phenotypes for Vasomotor Rhinitis

Drugs & Therapeutics for Vasomotor Rhinitis

Drugs for Vasomotor Rhinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azelastine Approved Phase 4 58581-89-8 2267
2
Histamine Approved, Investigational Phase 4,Phase 3 51-45-6 774
3 Analgesics Phase 4
4 Histamine Antagonists Phase 4,Phase 3
5
Histamine Phosphate Phase 4,Phase 3 51-74-1 65513
6 Lipoxygenase Inhibitors Phase 4
7 Anti-Inflammatory Agents Phase 4
8 Peripheral Nervous System Agents Phase 4,Phase 3
9 Neurotransmitter Agents Phase 4,Phase 3
10 Bronchodilator Agents Phase 4,Phase 3
11 Histamine H1 Antagonists Phase 4,Phase 3
12 Anti-Allergic Agents Phase 4,Phase 3
13 Respiratory System Agents Phase 4,Phase 3
14 Olopatadine Hydrochloride Phase 4
15 Antirheumatic Agents Phase 4
16 Autonomic Agents Phase 4,Phase 3
17 Anti-Inflammatory Agents, Non-Steroidal Phase 4
18 Histamine H1 Antagonists, Non-Sedating Phase 4,Phase 3
19 Anti-Asthmatic Agents Phase 4,Phase 3
20 Analgesics, Non-Narcotic Phase 4
21
Ephedrine Approved Phase 3 299-42-3 9294
22
Pseudoephedrine Approved Phase 3 90-82-4 7028
23
Levocetirizine Approved Phase 3 130018-77-8 1549000
24
Cetirizine Approved Phase 3 83881-51-0 2678
25
Oxymetazoline Approved, Investigational Phase 3 1491-59-4 4636
26
Phenylephrine Approved Phase 3 59-42-7 6041
27 Nasal Decongestants Phase 3
28 Sympathomimetics Phase 3
29 Central Nervous System Stimulants Phase 3
30 Adrenergic Agents Phase 3
31 Vasoconstrictor Agents Phase 3
32 Adrenergic Agonists Phase 3
33 Cardiotonic Agents Phase 3
34 Adrenergic alpha-Agonists Phase 3
35 Mydriatics Phase 3
36 Protective Agents Phase 3
37
Esomeprazole Approved, Investigational Not Applicable 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
38 Anti-Ulcer Agents Not Applicable
39 Gastrointestinal Agents Not Applicable
40 Antacids Not Applicable
41 Proton Pump Inhibitors Not Applicable
42 Pharmaceutical Solutions Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Olopatadine 0.6% and Azelastine 137 Mcg in Vasomotor Rhinitis Completed NCT00979615 Phase 4 Olopatadine HCL (Patanase) Nasal Spray, 0.6%;Azelastine HCl (Astelin) Nasal Spray, 137 mcg
2 Efficacy/Safety of Pseudoephedrine Plus Levocetirizine Versus Placebo in Patients With Vasomotor Rhinitis Completed NCT01509209 Phase 3 Pseudoephedrine / Levocetirizine
3 Impact of Acupuncture on Vasomotor Rhinitis Completed NCT00682162 Phase 3
4 Once-Daily Investigational Nasal Spray In Adults And Adolescents With Vasomotor Rhinitis Completed NCT00118703 Phase 3 GW685698X
5 Study Of Adults And Adolescents With Vasomotor Rhinitis Completed NCT00117325 Phase 3 GW685698X
6 Consumer Preference Study of Two Formulations of Phenylephrine Hydrochloride (Study CL2008-15)(P07530)(COMPLETED) Completed NCT00976209 Phase 3 Phenylephrine Hydrochloride (HCl) Extended Release (ER) Tablets 30 mg;Phenylephrine Hydrochloride (HCl) Immediate Release (IR) tablets, 10 mg
7 Nasal Physiologic Reactivity of Nonallergic Rhinitics to Cold Air Provocation Completed NCT00415493 Not Applicable
8 Efficacy of Esomeprazole for Non-Allergic Rhinitis: A Double-Blind, Placebo Controlled Trial Completed NCT00745849 Not Applicable esomeprazole;placebo
9 PBASE System Idiopathic Rhinitis Clinical Investigation Completed NCT01844336 Not Applicable
10 Nasal Saline Irrigation After Radiation Therapy for Oropharyngeal Cancer Completed NCT02338102 Not Applicable

Search NIH Clinical Center for Vasomotor Rhinitis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: rhinitis, vasomotor

Genetic Tests for Vasomotor Rhinitis

Anatomical Context for Vasomotor Rhinitis

Publications for Vasomotor Rhinitis

Articles related to Vasomotor Rhinitis:

(show top 50) (show all 201)
# Title Authors Year
1
A Pilot Study Investigating Clinical Responses and Biological Pathways of Azelastine/Fluticasone in Nonallergic Vasomotor Rhinitis before and after Cold Dry Air Provocation. ( 28787742 )
2017
2
Severity of nasal obstruction can predict the anxiety status of patients with allergic rhinitis but not patients with vasomotor rhinitis. ( 27277070 )
2016
3
Association between vasomotor rhinitis and irritable bowel syndrome. ( 28683253 )
2016
4
Surgical management of vasomotor rhinitis: a systematic review. ( 25785754 )
2015
5
Vitamin D serum levels in children with allergic and vasomotor rhinitis. ( 26512257 )
2015
6
Therapeutic effectiveness of endoscopic vidian neurectomy for the treatment of vasomotor rhinitis. ( 24433056 )
2014
7
Intranasal capsaicin in management of nonallergic (vasomotor) rhinitis. ( 24941668 )
2014
8
Cytologic alterations in nasal mucosa after sphenopalatine artery ligation in patients with vasomotor rhinitis. ( 22391083 )
2012
9
Severe unilateral vasomotor rhinitis: an antecedent sign of vascular compromise? ( 22672492 )
2012
10
Traumatic unilateral vasomotor rhinitis. ( 23288805 )
2012
11
Sphenopalatine artery ligation with nerve resection in patients with vasomotor rhinitis and polyposis: a prospective, randomized, double-blind investigation. ( 22339556 )
2012
12
Olopatadine 0.6% nasal spray protects from vasomotor challenge in patients with severe vasomotor rhinitis. ( 21819751 )
2011
13
Two-week comparison study of olopatadine hydrochloride nasal spray 0.6% versus azelastine hydrochloride nasal spray 0.1% in patients with vasomotor rhinitis. ( 21352639 )
2011
14
Nonallergic rhinopathy (formerly known as vasomotor rhinitis). ( 21737036 )
2011
15
Vasomotor rhinitis. ( 20425499 )
2010
16
Impact of acupuncture on vasomotor rhinitis: a randomized placebo-controlled pilot study. ( 19388861 )
2009
17
Weather/temperature-sensitive vasomotor rhinitis may be refractory to intranasal corticosteroid treatment. ( 19463202 )
2009
18
Nonallergic rhinitis, with a focus on vasomotor rhinitis: clinical importance, differential diagnosis, and effective treatment recommendations. ( 23282951 )
2009
19
Consensus Review and Definition of Nonallergic Rhinitis With a Focus on Vasomotor Rhinitis, Proposed to Be Known henceforth as Nonallergic Rhinopathy: Introduction to Part 2. ( 24228749 )
2009
20
The role of antihistamines in the treatment of vasomotor rhinitis. ( 24228781 )
2009
21
The treatment of vasomotor rhinitis with intranasal corticosteroids. ( 24228841 )
2009
22
Consensus Description of Inclusion and Exclusion Criteria for Clinical Studies of Nonallergic Rhinopathy (NAR), Previously Referred to as Vasomotor Rhinitis (VMR), Nonallergic Rhinitis, and/or Idiopathic Rhinitis. ( 24228856 )
2009
23
Characteristics of nonallergic vasomotor rhinitis. ( 24228982 )
2009
24
Epidemiology of vasomotor rhinitis. ( 24229078 )
2009
25
Consensus Definition of Nonallergic Rhinopathy, Previously Referred to as Vasomotor Rhinitis, Nonallergic Rhinitis, and/or Idiopathic Rhinitis. ( 24229320 )
2009
26
Consensus Review and Definition of Nonallergic Rhinitis With a Focus on Vasomotor Rhinitis, Proposed to be Known henceforth as Nonallergic Rhinopathy Part 1. Introduction. ( 24229340 )
2009
27
Classification of Nonallergic Rhinitis Syndromes With a Focus on Vasomotor Rhinitis, Proposed to be Known henceforth as Nonallergic Rhinopathy. ( 24229372 )
2009
28
Olfactory receptor gene polymorphisms and nonallergic vasomotor rhinitis. ( 18446592 )
2008
29
[The expression of serum IL-10,12,13,16 in patients with allergic rhinitis and vasomotor rhinitis]. ( 18254318 )
2007
30
Nasal wall compliance in vasomotor rhinitis. ( 16141379 )
2006
31
CT assessment of the effect of fluticasone propionate aqueous nasal spray treatment on lower turbinate hypertrophy due to vasomotor rhinitis. ( 16308253 )
2006
32
Questionnaire evaluation and risk factor identification for nonallergic vasomotor rhinitis. ( 16680922 )
2006
33
The effect of intranasal injection of botulinum toxin A on the symptoms of vasomotor rhinitis. ( 16935174 )
2006
34
Autonomic nervous system evaluation using heart rate variability parameters in vasomotor rhinitis patients. ( 17049152 )
2006
35
[The roles of three peptides in the pathogenesis of vasomotor rhinitis]. ( 17087112 )
2006
36
Immunohistochemical localization of 3-nitrotyrosine in the nasal respiratory mucosa of patients with vasomotor rhinitis. ( 15799577 )
2005
37
Open-label evaluation of azelastine nasal spray in patients with seasonal allergic rhinitis and nonallergic vasomotor rhinitis. ( 15899111 )
2005
38
Vasomotor rhinitis. ( 16190503 )
2005
39
Radiofrequency for the treatment of vasomotor rhinitis. ( 16340279 )
2005
40
Mechanisms of vasomotor rhinitis. ( 14984550 )
2004
41
Vasomotor rhinitis update. ( 15167037 )
2004
42
Bioavailability and pharmacokinetics of intranasal hydromorphone in patients experiencing vasomotor rhinitis. ( 17523726 )
2004
43
Vasomotor rhinitis is not a wastebasket diagnosis. ( 12759275 )
2003
44
Vasomotor rhinitis remains a true clinical problem. ( 12759276 )
2003
45
Vasomotor rhinitis should not be a wastebasket diagnosis. ( 12759277 )
2003
46
Ultrastructural and ultracytochemical study of the human nasal respiratory epithelium in vasomotor rhinitis. ( 14606598 )
2003
47
Autonomic dysfunction, vasomotor rhinitis, and extraesophageal manifestations of gastroesophageal reflux. ( 11997777 )
2002
48
Electrophoretic evaluation of nasal discharge in patients with allergic rhinitis and vasomotor rhinitis. ( 12141770 )
2002
49
Vasomotor rhinitis: clinical efficacy of azelastine nasal spray in comparison with placebo. ( 11244365 )
2001
50
Therapy choices beyond antihistamines. Vasomotor rhinitis. ( 12420500 )
2001

Variations for Vasomotor Rhinitis

Expression for Vasomotor Rhinitis

Search GEO for disease gene expression data for Vasomotor Rhinitis.

Pathways for Vasomotor Rhinitis

Pathways related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.96 CALCA NPS VIP

GO Terms for Vasomotor Rhinitis

Cellular components related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 CALCA CD40LG IL16 RNASE3 TAC1
2 extracellular region GO:0005576 9.17 CALCA CD40LG IL16 NPS RNASE3 TAC1

Biological processes related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.8 CALCA NPS TAC1 VIP
2 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.51 CALCA VIP
3 regulation of blood pressure GO:0008217 9.48 CALCA TAC1
4 inflammatory response GO:0006954 9.46 CD40LG TAC1
5 regulation of signaling receptor activity GO:0010469 9.46 CALCA CD40LG IL16 VIP
6 leukocyte cell-cell adhesion GO:0007159 9.4 CALCA CD40LG
7 positive regulation of blood vessel diameter GO:0097755 9.37 CALCA VIP
8 positive regulation of synaptic transmission, GABAergic GO:0032230 9.26 NPS TAC1
9 cellular response to nerve growth factor stimulus GO:1990090 9.13 TAC1
10 response to pain GO:0048265 9.02 TAC1
11 neuropeptide signaling pathway GO:0007218 8.96 NPS TAC1
12 positive regulation of action potential GO:0045760 8.62 NPS TAC1

Molecular functions related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 CALCA VIP

Sources for Vasomotor Rhinitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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