MCID: VSM001
MIFTS: 38

Vasomotor Rhinitis

Categories: Respiratory diseases

Aliases & Classifications for Vasomotor Rhinitis

MalaCards integrated aliases for Vasomotor Rhinitis:

Name: Vasomotor Rhinitis 12 15 17 32
Rhinitis, Vasomotor 44 71
Rhinitis Vasomotor 54

Classifications:



External Ids:

Disease Ontology 12 DOID:4730
MeSH 44 D012223
NCIt 50 C34988
SNOMED-CT 67 155537009
ICD10 32 J30.0
UMLS 71 C0035460

Summaries for Vasomotor Rhinitis

Disease Ontology : 12 A rhinitis which involves a hypersensitive reaction to various potentially irritating stimuli such as changes in weather, temperature, or barometric pressure, chemical irritants such as smoke, ozone, pollution, perfumes, and aerosol sprays, psychological stress and emotional shocks, medications, alcohol, and spicy food.

MalaCards based summary : Vasomotor Rhinitis, also known as rhinitis, vasomotor, is related to rhinitis and pollen allergy. An important gene associated with Vasomotor Rhinitis is VIP (Vasoactive Intestinal Peptide), and among its related pathways/superpathways are Allograft rejection and Inflammatory Response Pathway. The drugs Histamine and Azelastine have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and cortex.

Related Diseases for Vasomotor Rhinitis

Diseases related to Vasomotor Rhinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
# Related Disease Score Top Affiliating Genes
1 rhinitis 30.9 VIP RNASE3 KNG1 IL5 IL13
2 pollen allergy 30.6 RNASE3 IL5 IL13
3 hypereosinophilic syndrome 30.3 RNASE3 IL5 IL13
4 chronic rhinitis 30.1 TAC1 RNASE3 IL5 IL13
5 irritable bowel syndrome 30.0 VIP TRPV1 TAC1
6 allergic disease 29.9 RNASE3 IL5 IL13
7 allergic rhinitis 29.9 VIP RNASE3 KNG1 IL5 IL16 IL13
8 respiratory allergy 29.8 RNASE3 IL5 IL13
9 ige responsiveness, atopic 29.8 RNASE3 IL5 IL13
10 food allergy 29.8 RNASE3 IL5 IL13
11 trigeminal neuralgia 29.7 TRPV1 TAC1 KNG1 CALCA
12 bronchitis 29.4 VIP TAC1 RNASE3 IL5 IL13
13 urticaria 29.3 RNASE3 IL5 IL13 CMA1
14 dermatitis, atopic 28.6 VIP TAC1 RNASE3 IL5 IL16 IL13
15 leprosy 2 10.4 VIP CALCA
16 carbamazepine allergy 10.3 TAC1 CALCA
17 endocrine pancreas disease 10.3 VIP CALCA
18 cluster headache 10.3 VIP CALCA
19 taylor's syndrome 10.3 TAC1 CALCA
20 neurogenic bowel 10.3 VIP TAC1
21 pancreatic cholera 10.3 VIP CALCA
22 anismus 10.3 VIP TAC1
23 neurogenic arthropathy 10.3 TAC1 CALCA
24 endometrial small cell carcinoma 10.3 VIP TAC1
25 plantar fasciitis 10.3 TAC1 CALCA
26 paralytic ileus 10.3 VIP TAC1
27 epicondylitis 10.3 TAC1 CALCA
28 autonomic nervous system benign neoplasm 10.3 VIP CALCA
29 peripheral nervous system benign neoplasm 10.3 VIP CALCA
30 prurigo nodularis 10.3 TAC1 RNASE3
31 functional gastric disease 10.3 VIP TAC1
32 autonomic dysfunction 10.2
33 acute asthma 10.2 RNASE3 IL5
34 hyperhidrosis, gustatory 10.2 TRPV1 TAC1
35 loeffler endocarditis 10.2 RNASE3 IL5
36 gastroesophageal reflux 10.2
37 atopic keratoconjunctivitis 10.2 RNASE3 IL5
38 neurodermatitis 10.2 TAC1 IL13
39 migraine with aura 10.2 VIP TAC1 CALCA
40 cryptosporidiosis 10.2 VIP TAC1 CD40LG
41 childhood-onset asthma 10.2 RNASE3 IL13
42 vipoma 10.2 VIP CALCA
43 pustulosis palmaris et plantaris 10.2 IL5 CD40LG
44 disseminated eosinophilic collagen disease 10.1 RNASE3 IL5
45 exercise-induced bronchoconstriction 10.1 RNASE3 IL13
46 pseudopterygium 10.1 TRPV1 TAC1
47 pemphigoid gestationis 10.1 RNASE3 IL5
48 chronic cystitis 10.1 TRPV1 TAC1
49 endomyocardial fibrosis 10.1 RNASE3 IL5
50 dental pulp disease 10.1 TRPV1 TAC1

Graphical network of the top 20 diseases related to Vasomotor Rhinitis:



Diseases related to Vasomotor Rhinitis

Symptoms & Phenotypes for Vasomotor Rhinitis

Drugs & Therapeutics for Vasomotor Rhinitis

Drugs for Vasomotor Rhinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
2
Azelastine Approved Phase 4 58581-89-8 2267
3 Respiratory System Agents Phase 4
4 Anti-Inflammatory Agents Phase 4
5 Anti-Asthmatic Agents Phase 4
6 Analgesics, Non-Narcotic Phase 4
7 Neurotransmitter Agents Phase 4
8 Olopatadine Hydrochloride Phase 4
9 Anti-Inflammatory Agents, Non-Steroidal Phase 4
10 Histamine Antagonists Phase 4
11
Histamine Phosphate Phase 4 51-74-1 65513
12 Anti-Allergic Agents Phase 4
13 Analgesics Phase 4
14 Antirheumatic Agents Phase 4
15 Histamine H1 Antagonists Phase 4
16 Histamine H1 Antagonists, Non-Sedating Phase 4
17 Bronchodilator Agents Phase 4
18
Levocetirizine Approved Phase 3 130018-77-8 1549000
19
Ephedrine Approved Phase 3 299-42-3 9294
20
Pseudoephedrine Approved Phase 3 90-82-4 7028
21
Phenylephrine Approved Phase 3 59-42-7 6041
22
Oxymetazoline Approved, Investigational Phase 3 1491-59-4 4636
23 Central Nervous System Stimulants Phase 3
24 Nasal Decongestants Phase 3
25 Sympathomimetics Phase 3
26 Vasoconstrictor Agents Phase 3
27 Adrenergic Agents Phase 3
28 Protective Agents Phase 3
29 Cardiotonic Agents Phase 3
30 Adrenergic alpha-Agonists Phase 3
31 Mydriatics Phase 3
32 Adrenergic Agonists Phase 3
33
Esomeprazole Approved, Investigational 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
34
Isotretinoin Approved 4759-48-2 5538 5282379
35 Gastrointestinal Agents
36 Anti-Ulcer Agents
37 Antacids
38 Proton Pump Inhibitors
39 Pharmaceutical Solutions
40 Liver Extracts
41 Dermatologic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Olopatadine 0.6% and Azelastine 137 Mcg in Vasomotor Rhinitis Completed NCT00979615 Phase 4 Olopatadine HCL (Patanase) Nasal Spray, 0.6%;Azelastine HCl (Astelin) Nasal Spray, 137 mcg
2 Impact of Acupuncture on Vasomotor Rhinitis: a Randomised Placebo Controlled Pilot Study Completed NCT00682162 Phase 3
3 A 4 Week Randomized, Double Blind, Placebo Controlled Study of GW685698X Aq Nasal Spray 100mcg QD in Adults and Adolescents With Vasomotor Rhinitis Completed NCT00118703 Phase 3 GW685698X
4 Efficacy and Safety of Cossac L Tablet in Vasomotor Rhinitis Patients : A Randomized, Double-blind, Placebo-controlled, Phase 3 Clinical Trial Completed NCT01509209 Phase 3 Pseudoephedrine / Levocetirizine
5 A Randomized, Two-Way Crossover, Multicenter, Consumer Preference Study of Two Oral Formulations of Phenylephrine Hydrochloride. Completed NCT00976209 Phase 3 Phenylephrine Hydrochloride (HCl) Extended Release (ER) Tablets 30 mg;Phenylephrine Hydrochloride (HCl) Immediate Release (IR) tablets, 10 mg
6 A 4 Week Randomized, Double Blind, Placebo Controlled Study of GW685698X Aq Nasal Spray 100mcg QD in Adults and Adolescents With Vasomotor Rhinitis Completed NCT00117325 Phase 3 GW685698X
7 Efficacy of Esomeprazole for Non-Allergic Rhinitis: A Double-blind, Placebo Controlled Trial Completed NCT00745849 esomeprazole;placebo
8 Nasal Physiologic Reactivity of Nonallergic Rhinitics to Cold Air Provocation Completed NCT00415493
9 Nasal Saline Irrigation After Radiation Therapy for Oropharyngeal Cancer: A Pilot Study Completed NCT02338102
10 Treatment of Acne Vulgaris Using 1,565 nm Non-ablative Fractional Laser in Combination With Isotretinoin and Pricking Blood Therapy Completed NCT04156815 Oral isotretinoin

Search NIH Clinical Center for Vasomotor Rhinitis

Inferred drug relations via UMLS 71 / NDF-RT 51 :


azelastine
Azelastine hydrochloride
Brompheniramine
Brompheniramine Maleate
carbinoxamine
Carbinoxamine maleate
Ipratropium
Ipratropium Bromide
Phenylephrine
Phenylephrine bitartrate
Phenylephrine Hydrochloride
Phenylephrine Tannate
Phenylpropanolamine Hydrochloride
Scopolamine
Scopolamine Hydrobromide
tetrahydrozoline
Tetrahydrozoline hydrochloride

Cochrane evidence based reviews: rhinitis, vasomotor

Genetic Tests for Vasomotor Rhinitis

Anatomical Context for Vasomotor Rhinitis

MalaCards organs/tissues related to Vasomotor Rhinitis:

40
Liver, Skin, Cortex, Thyroid, Adrenal Cortex

Publications for Vasomotor Rhinitis

Articles related to Vasomotor Rhinitis:

(show top 50) (show all 661)
# Title Authors PMID Year
1
[The roles of three peptides in the pathogenesis of vasomotor rhinitis]. 61 54
17087112 2006
2
Eosinophil inflammation of the nasal mucosa in allergic and non-allergic rhinitis measured by eosinophil cationic protein levels in native nasal fluid and serum. 61 54
7889429 1994
3
Diagnosis and treatment of non-allergic rhinitis: focus on immunologic mechanisms. 61
33259234 2020
4
Ultrasound-guided acupuncture of the sphenopalatine ganglion for the treatment of vasomotor rhinitis: a case report. 61
32233776 2020
5
[Evaluation and analysis of anxiety, depression and quality of life in vasomotor rhinitis]. 61
32791776 2020
6
Laser ablation of posterior nasal nerves for rhinitis. 61
31948695 2020
7
Newer Surgical Options for Nasal Allergy. 61
32158670 2020
8
[Halotherapy in patients with vasomotor rhinitis after surgical treatment]. 61
32687298 2020
9
Rhinorrhea as a Result of Alzheimer's Disease Treatment: A Case Report. 61
31818352 2019
10
Voice After Rhinoplasty. An Important Question for the Opera Singers. 61
31889647 2019
11
Asthma and allergies in pregnancy. 61
31690383 2019
12
Allergic and nonallergic rhinitis. 61
31690374 2019
13
Intranasal corticosteroids for non-allergic rhinitis. 61
31677153 2019
14
[Endoscopic posterior nasal neurectomy]. 61
31439065 2019
15
[Application of nasal saline irrigation in nasal inflammatory diseases]. 61
30669208 2019
16
[Therapeutic effect of nasal corticosteroids combined with nasal antihistamine on vasomotor rhinitis]. 61
30550209 2018
17
Cryotherapy for the Treatment of Chronic Rhinitis: A Qualitative Systematic Review. 61
30229670 2018
18
Surgical Management of Nonallergic Rhinitis. 61
29937065 2018
19
[Treatment of allergic and vasomotor rhinitis: the role of beclomethasone dipropionate and hyaluronic acid (with high molecular weight).] 61
29689043 2018
20
[Innovative technology full volume lavage of the nasal cavity in the treatment of allergic and vasomotor rhinitis]. 61
30412178 2018
21
[Cryosurgery in the treatment of allergic and non-allergic rhinitis]. 61
30267489 2018
22
[A variant of the modification of the rhinosurgical intervention with the use of the hemostatic glue]. 61
30412179 2018
23
[Research advances of pregnancy rhinitis]. 61
29798199 2017
24
Prognostic value of nasal cytology and clinical factors in nasal polyps development in patients at risk: can the beginning predict the end? 61
28665504 2017
25
[Clinical symptoms and immunology inspection characteristics of nasal cavity local allergy]. 61
29798346 2017
26
[Nasal irrigation for the treatment of vasomotor rhinitis: a pilot study]. 61
28635218 2017
27
[Nasal turbinate surgery]. 61
28401248 2017
28
A Pilot Study Investigating Clinical Responses and Biological Pathways of Azelastine/Fluticasone in Nonallergic Vasomotor Rhinitis before and after Cold Dry Air Provocation. 61
28787742 2017
29
Nasal Muco-ciliary transport time alteration: efficacy of 18 B Glycyrrhetinic acid. 61
29209499 2017
30
Combination therapy in allergic rhinitis: What works and what does not work. 61
28124648 2016
31
Severity of nasal obstruction can predict the anxiety status of patients with allergic rhinitis but not patients with vasomotor rhinitis. 61
27277070 2016
32
Is the location of a septal deviation associated with the degree of postoperative pain after septoplasty? 61
27792832 2016
33
Inferior Turbinate Hypertrophy in Rhinoplasty: Systematic Review of Surgical Techniques. 61
27556616 2016
34
Pathogenesis of rhinitis. 61
27434218 2016
35
NASAL cytology: practical aspects and clinical relevance. 61
27009397 2016
36
Nonallergic Rhinitis: Treatment. 61
27083104 2016
37
Association between vasomotor rhinitis and irritable bowel syndrome. 61
28683253 2016
38
[Acute respiratory viral infections: Topical issues of diagnosis, prevention and treatment in therapeutic practice]. 61
28005035 2016
39
[About the unresolved problems of terminology and classification of allergic rhinitis and the desirability of distinguishing the mixed form of the disease]. 61
27876734 2016
40
Vitamin D serum levels in children with allergic and vasomotor rhinitis. 61
26512257 2015
41
Endoscopic vidian neurectomy: a prospective case series. 61
25732231 2015
42
Surgical management of vasomotor rhinitis: a systematic review. 61
25785754 2015
43
[The modern approach to the treatment of the patients presenting with vasomotor rhinitis with the use of the electrosurgical technique]. 61
26145748 2015
44
[The disturbances of vegetative homeostasis in the children suffering from vasomotor rhinitis]. 61
26145742 2015
45
"Overlapped" rhinitis: a real trap for rhinoallergologists. 61
25398169 2014
46
[The topical treatment of allergic and vasomotor rhinitis: the role of beclomethasone dipropionate]. 61
25424236 2014
47
Rhinorrhea triggered by obturator prosthesis after surgical intervention of partial maxillary resection: a clinical report. 61
25503096 2014
48
[Diagnosis and clinical characteristics of patients with non-allergic rhinitis]. 61
25241870 2014
49
Long-term, randomized safety study of MP29-02 (a novel intranasal formulation of azelastine hydrochloride and fluticasone propionate in an advanced delivery system) in subjects with chronic rhinitis. 61
24607046 2014
50
Therapeutic effectiveness of endoscopic vidian neurectomy for the treatment of vasomotor rhinitis. 61
24433056 2014

Variations for Vasomotor Rhinitis

Expression for Vasomotor Rhinitis

Search GEO for disease gene expression data for Vasomotor Rhinitis.

Pathways for Vasomotor Rhinitis

GO Terms for Vasomotor Rhinitis

Cellular components related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 TAC1 RNASE3 KNG1 IL5 IL16 IL13
2 extracellular region GO:0005576 9.32 VIP TAC1 RNASE3 KNG1 IL5 IL16

Biological processes related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.8 IL5 IL16 IL13 CD40LG
2 leukocyte cell-cell adhesion GO:0007159 9.52 CD40LG CALCA
3 microglial cell activation GO:0001774 9.51 TRPV1 IL13
4 vasodilation GO:0042311 9.48 KNG1 CALCA
5 positive regulation of immunoglobulin production GO:0002639 9.46 IL5 IL13
6 positive regulation of cytosolic calcium ion concentration GO:0007204 9.46 TRPV1 TAC1 KNG1 CALCA
7 positive regulation of blood vessel diameter GO:0097755 9.43 VIP CALCA
8 cellular response to nerve growth factor stimulus GO:1990090 9.43 TRPV1 TAC1 CALCA
9 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.4 TRPV1 CALCA
10 negative regulation of heart rate GO:0010459 9.37 TRPV1 TAC1
11 positive regulation of interleukin-1 alpha production GO:0032730 9.32 IL16 CALCA
12 inflammatory response GO:0006954 9.17 TRPV1 TAC1 KNG1 IL5 IL13 CD40LG
13 response to pain GO:0048265 9.13 TRPV1 TAC1 CALCA

Molecular functions related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 IL5 IL16 IL13 CD40LG

Sources for Vasomotor Rhinitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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