MCID: VSM001
MIFTS: 35

Vasomotor Rhinitis

Categories: Respiratory diseases

Aliases & Classifications for Vasomotor Rhinitis

MalaCards integrated aliases for Vasomotor Rhinitis:

Name: Vasomotor Rhinitis 12 15
Rhinitis, Vasomotor 44 73
Rhinitis Vasomotor 55

Classifications:



External Ids:

Disease Ontology 12 DOID:4730
ICD10 33 J30.0
MeSH 44 D012223
NCIt 50 C34988
SNOMED-CT 68 8229003
UMLS 73 C0035460

Summaries for Vasomotor Rhinitis

Disease Ontology : 12 A rhinitis which involves a hypersensitive reaction to various potentially irritating stimuli such as changes in weather, temperature, or barometric pressure, chemical irritants such as smoke, ozone, pollution, perfumes, and aerosol sprays, psychological stress and emotional shocks, medications, alcohol, and spicy food.

MalaCards based summary : Vasomotor Rhinitis, also known as rhinitis, vasomotor, is related to rhinitis and allergic rhinitis. An important gene associated with Vasomotor Rhinitis is VIP (Vasoactive Intestinal Peptide), and among its related pathways/superpathways is G alpha (s) signalling events. The drugs Histamine and Azelastine have been mentioned in the context of this disorder. Affiliated tissues include heart.

Related Diseases for Vasomotor Rhinitis

Diseases related to Vasomotor Rhinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 rhinitis 31.9 RNASE3 VIP
2 allergic rhinitis 30.4 RNASE3 VIP
3 irritable bowel syndrome 30.0 TAC1 VIP
4 asthma 29.4 CALCA CD40LG IL16 RNASE3 TAC1 VIP
5 anxiety 10.1
6 anismus 10.1 TAC1 VIP
7 wdha syndrome 10.1 CALCA VIP
8 leprosy 2 10.1 CALCA VIP
9 cluster headache 10.1 CALCA VIP
10 pancreatic cholera 10.1 CALCA VIP
11 somatostatinoma 10.1 CALCA VIP
12 prurigo nodularis 10.1 RNASE3 TAC1
13 burn scar 10.1 CALCA TAC1
14 islet cell tumor 10.1 CALCA VIP
15 autonomic nervous system disease 10.0 CALCA TAC1
16 brachial plexus lesion 10.0 CALCA TAC1
17 causalgia 10.0 CALCA TAC1
18 complex regional pain syndrome 10.0 CALCA TAC1
19 nasal cavity disease 10.0 RNASE3 TAC1
20 nose disease 10.0 RNASE3 TAC1
21 hemiplegia 10.0 CALCA TAC1
22 alternating hemiplegia of childhood 10.0 CALCA TAC1
23 upper respiratory tract disease 10.0 RNASE3 TAC1
24 meningoencephalitis 10.0 CD40LG TAC1
25 gastroesophageal reflux 10.0
26 sinusitis 10.0
27 pollen allergy 10.0
28 hyperinsulinism 10.0
29 atrophic rhinitis 10.0
30 bronchial disease 10.0 RNASE3 TAC1
31 endocrine gland cancer 9.9 CALCA VIP
32 diffuse pulmonary fibrosis 9.9 CALCA TAC1 VIP
33 bronchitis 9.9 RNASE3 TAC1 VIP
34 constipation 9.9 CALCA TAC1 VIP
35 migraine with or without aura 1 9.9 CALCA TAC1 VIP
36 schistosomiasis 9.9 CD40LG RNASE3
37 cryptosporidiosis 9.9 CD40LG TAC1 VIP
38 allergic asthma 9.8 IL16 RNASE3
39 dermatitis, atopic 9.8 IL16 RNASE3 VIP
40 inflammatory bowel disease 9.6 IL16 TAC1 VIP

Graphical network of the top 20 diseases related to Vasomotor Rhinitis:



Diseases related to Vasomotor Rhinitis

Symptoms & Phenotypes for Vasomotor Rhinitis

Drugs & Therapeutics for Vasomotor Rhinitis

Drugs for Vasomotor Rhinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4,Phase 3 51-45-6, 75614-87-8 774
2
Azelastine Approved Phase 4 58581-89-8 2267
3
Histamine Phosphate Phase 4,Phase 3 51-74-1 65513
4 Bronchodilator Agents Phase 4,Phase 3
5 Histamine H1 Antagonists, Non-Sedating Phase 4,Phase 3
6 Analgesics Phase 4
7 Histamine Antagonists Phase 4,Phase 3
8 Anti-Allergic Agents Phase 4,Phase 3
9 Peripheral Nervous System Agents Phase 4,Phase 3
10 Lipoxygenase Inhibitors Phase 4
11 Analgesics, Non-Narcotic Phase 4
12 Anti-Inflammatory Agents, Non-Steroidal Phase 4
13 Olopatadine Hydrochloride Phase 4
14 Anti-Inflammatory Agents Phase 4
15 Anti-Asthmatic Agents Phase 4,Phase 3
16 Autonomic Agents Phase 4,Phase 3
17 Histamine H1 Antagonists Phase 4,Phase 3
18 Respiratory System Agents Phase 4,Phase 3
19 Neurotransmitter Agents Phase 4,Phase 3
20 Antirheumatic Agents Phase 4
21
Pseudoephedrine Approved Phase 3 90-82-4 7028
22
Levocetirizine Approved Phase 3 130018-77-8 1549000
23
Cetirizine Approved Phase 3 83881-51-0 2678
24
Ephedrine Approved Phase 3 299-42-3 9294
25
Phenylephrine Approved Phase 3 59-42-7 6041
26
Oxymetazoline Approved, Investigational Phase 3 1491-59-4 4636
27 Sympathomimetics Phase 3
28 Central Nervous System Stimulants Phase 3
29 Nasal Decongestants Phase 3
30 Adrenergic Agents Phase 3
31 Vasoconstrictor Agents Phase 3
32 Mydriatics Phase 3
33 Adrenergic alpha-Agonists Phase 3
34 Adrenergic Agonists Phase 3
35 Cardiotonic Agents Phase 3
36 Protective Agents Phase 3
37
Esomeprazole Approved, Investigational Not Applicable 161796-78-7, 119141-88-7 4594 9579578
38 Anti-Ulcer Agents Not Applicable
39 Antacids Not Applicable
40 Proton Pump Inhibitors Not Applicable
41 Gastrointestinal Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Olopatadine 0.6% and Azelastine 137 Mcg in Vasomotor Rhinitis Completed NCT00979615 Phase 4 Olopatadine HCL (Patanase) Nasal Spray, 0.6%;Azelastine HCl (Astelin) Nasal Spray, 137 mcg
2 Efficacy/Safety of Pseudoephedrine Plus Levocetirizine Versus Placebo in Patients With Vasomotor Rhinitis Completed NCT01509209 Phase 3 Pseudoephedrine / Levocetirizine
3 Impact of Acupuncture on Vasomotor Rhinitis Completed NCT00682162 Phase 3
4 Once-Daily Investigational Nasal Spray In Adults And Adolescents With Vasomotor Rhinitis Completed NCT00118703 Phase 3 GW685698X
5 Study Of Adults And Adolescents With Vasomotor Rhinitis Completed NCT00117325 Phase 3 GW685698X
6 Consumer Preference Study of Two Formulations of Phenylephrine Hydrochloride (Study CL2008-15)(P07530)(COMPLETED) Completed NCT00976209 Phase 3 Phenylephrine Hydrochloride (HCl) Extended Release (ER) Tablets 30 mg;Phenylephrine Hydrochloride (HCl) Immediate Release (IR) tablets, 10 mg
7 Nasal Physiologic Reactivity of Nonallergic Rhinitics to Cold Air Provocation Completed NCT00415493 Not Applicable
8 Efficacy of Esomeprazole for Non-Allergic Rhinitis: A Double-Blind, Placebo Controlled Trial Completed NCT00745849 Not Applicable esomeprazole;placebo
9 PBASE System Idiopathic Rhinitis Clinical Investigation Completed NCT01844336 Not Applicable

Search NIH Clinical Center for Vasomotor Rhinitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: rhinitis, vasomotor

Genetic Tests for Vasomotor Rhinitis

Anatomical Context for Vasomotor Rhinitis

MalaCards organs/tissues related to Vasomotor Rhinitis:

41
Heart

Publications for Vasomotor Rhinitis

Articles related to Vasomotor Rhinitis:

(show top 50) (show all 201)
# Title Authors Year
1
A Pilot Study Investigating Clinical Responses and Biological Pathways of Azelastine/Fluticasone in Nonallergic Vasomotor Rhinitis before and after Cold Dry Air Provocation. ( 28787742 )
2017
2
Association between vasomotor rhinitis and irritable bowel syndrome. ( 28683253 )
2016
3
Severity of nasal obstruction can predict the anxiety status of patients with allergic rhinitis but not patients with vasomotor rhinitis. ( 27277070 )
2016
4
Surgical management of vasomotor rhinitis: A systematic review. ( 25785754 )
2015
5
Vitamin D serum levels in children with allergic and vasomotor rhinitis. ( 26512257 )
2015
6
Intranasal capsaicin in management of nonallergic (vasomotor) rhinitis. ( 24941668 )
2014
7
Therapeutic effectiveness of endoscopic vidian neurectomy for the treatment of vasomotor rhinitis. ( 24433056 )
2014
8
Cytologic alterations in nasal mucosa after sphenopalatine artery ligation in patients with vasomotor rhinitis. ( 22391083 )
2012
9
Sphenopalatine artery ligation with nerve resection in patients with vasomotor rhinitis and polyposis: a prospective, randomized, double-blind investigation. ( 22339556 )
2012
10
Severe unilateral vasomotor rhinitis: an antecedent sign of vascular compromise? ( 22672492 )
2012
11
Traumatic unilateral vasomotor rhinitis. ( 23288805 )
2012
12
Olopatadine 0.6% nasal spray protects from vasomotor challenge in patients with severe vasomotor rhinitis. ( 21819751 )
2011
13
Nonallergic rhinopathy (formerlyA known as vasomotor rhinitis). ( 21737036 )
2011
14
Two-week comparison study of olopatadine hydrochloride nasal spray 0.6% versus azelastine hydrochloride nasal spray 0.1% in patients with vasomotor rhinitis. ( 21352639 )
2011
15
Vasomotor rhinitis. ( 20425499 )
2010
16
Epidemiology of vasomotor rhinitis. ( 24229078 )
2009
17
Classification of Nonallergic Rhinitis Syndromes With a Focus on Vasomotor Rhinitis, Proposed to be Known henceforth as Nonallergic Rhinopathy. ( 24229372 )
2009
18
Consensus Review and Definition of Nonallergic Rhinitis With a Focus on Vasomotor Rhinitis, Proposed to Be Known henceforth as Nonallergic Rhinopathy: Introduction to Part 2. ( 24228749 )
2009
19
Characteristics of nonallergic vasomotor rhinitis. ( 24228982 )
2009
20
Consensus Review and Definition of Nonallergic Rhinitis With a Focus on Vasomotor Rhinitis, Proposed to be Known henceforth as Nonallergic Rhinopathy Part 1. Introduction. ( 24229340 )
2009
21
Nonallergic rhinitis, with a focus on vasomotor rhinitis: clinical importance, differential diagnosis, and effective treatment recommendations. ( 23282951 )
2009
22
Consensus Definition of Nonallergic Rhinopathy, Previously Referred to as Vasomotor Rhinitis, Nonallergic Rhinitis, and/or Idiopathic Rhinitis. ( 24229320 )
2009
23
The role of antihistamines in the treatment of vasomotor rhinitis. ( 24228781 )
2009
24
The treatment of vasomotor rhinitis with intranasal corticosteroids. ( 24228841 )
2009
25
Impact of acupuncture on vasomotor rhinitis: a randomized placebo-controlled pilot study. ( 19388861 )
2009
26
Consensus Description of Inclusion and Exclusion Criteria for Clinical Studies of Nonallergic Rhinopathy (NAR), Previously Referred to as Vasomotor Rhinitis (VMR), Nonallergic Rhinitis, and/or Idiopathic Rhinitis. ( 24228856 )
2009
27
Weather/temperature-sensitive vasomotor rhinitis may be refractory to intranasal corticosteroid treatment. ( 19463202 )
2009
28
Olfactory receptor gene polymorphisms and nonallergic vasomotor rhinitis. ( 18446592 )
2008
29
[The expression of serum IL-10,12,13,16 in patients with allergic rhinitis and vasomotor rhinitis]. ( 18254318 )
2007
30
The effect of intranasal injection of botulinum toxin A on the symptoms of vasomotor rhinitis. ( 16935174 )
2006
31
Autonomic nervous system evaluation using heart rate variability parameters in vasomotor rhinitis patients. ( 17049152 )
2006
32
Nasal wall compliance in vasomotor rhinitis. ( 16141379 )
2006
33
CT assessment of the effect of fluticasone propionate aqueous nasal spray treatment on lower turbinate hypertrophy due to vasomotor rhinitis. ( 16308253 )
2006
34
Questionnaire evaluation and risk factor identification for nonallergic vasomotor rhinitis. ( 16680922 )
2006
35
[The roles of three peptides in the pathogenesis of vasomotor rhinitis]. ( 17087112 )
2006
36
Immunohistochemical localization of 3-nitrotyrosine in the nasal respiratory mucosa of patients with vasomotor rhinitis. ( 15799577 )
2005
37
Radiofrequency for the treatment of vasomotor rhinitis. ( 16340279 )
2005
38
Vasomotor rhinitis. ( 16190503 )
2005
39
Open-label evaluation of azelastine nasal spray in patients with seasonal allergic rhinitis and nonallergic vasomotor rhinitis. ( 15899111 )
2005
40
Vasomotor rhinitis update. ( 15167037 )
2004
41
Bioavailability and pharmacokinetics of intranasal hydromorphone in patients experiencing vasomotor rhinitis. ( 17523726 )
2004
42
Mechanisms of vasomotor rhinitis. ( 14984550 )
2004
43
Ultrastructural and ultracytochemical study of the human nasal respiratory epithelium in vasomotor rhinitis. ( 14606598 )
2003
44
Vasomotor rhinitis remains a true clinical problem. ( 12759276 )
2003
45
Vasomotor rhinitis should not be a wastebasket diagnosis. ( 12759277 )
2003
46
Vasomotor rhinitis is not a wastebasket diagnosis. ( 12759275 )
2003
47
Autonomic dysfunction, vasomotor rhinitis, and extraesophageal manifestations of gastroesophageal reflux. ( 11997777 )
2002
48
Electrophoretic evaluation of nasal discharge in patients with allergic rhinitis and vasomotor rhinitis. ( 12141770 )
2002
49
Therapy choices beyond antihistamines. Vasomotor rhinitis. ( 12420500 )
2001
50
Vasomotor rhinitis: clinical efficacy of azelastine nasal spray in comparison with placebo. ( 11244365 )
2001

Variations for Vasomotor Rhinitis

Expression for Vasomotor Rhinitis

Search GEO for disease gene expression data for Vasomotor Rhinitis.

Pathways for Vasomotor Rhinitis

Pathways related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.79 CALCA VIP

GO Terms for Vasomotor Rhinitis

Cellular components related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular GO:0005622 9.46 CALCA CD40LG IL16 VIP
2 extracellular space GO:0005615 9.35 CALCA CD40LG IL16 RNASE3 TAC1
3 extracellular region GO:0005576 9.1 CALCA CD40LG IL16 RNASE3 TAC1 VIP

Biological processes related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.54 CALCA CD40LG TAC1
2 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.46 CALCA VIP
3 neuropeptide signaling pathway GO:0007218 9.43 CALCA TAC1
4 regulation of blood pressure GO:0008217 9.4 CALCA TAC1
5 cellular response to nerve growth factor stimulus GO:1990090 9.32 CALCA TAC1
6 leukocyte cell-cell adhesion GO:0007159 9.26 CALCA CD40LG
7 positive regulation of blood vessel diameter GO:0097755 9.16 CALCA VIP
8 response to pain GO:0048265 8.96 CALCA TAC1
9 regulation of signaling receptor activity GO:0010469 8.92 CALCA CD40LG IL16 VIP

Molecular functions related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 CALCA VIP

Sources for Vasomotor Rhinitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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