MCID: VSM001
MIFTS: 36

Vasomotor Rhinitis

Categories: Respiratory diseases

Aliases & Classifications for Vasomotor Rhinitis

MalaCards integrated aliases for Vasomotor Rhinitis:

Name: Vasomotor Rhinitis 12 15 17 33
Rhinitis, Vasomotor 44 72
Rhinitis Vasomotor 55

Classifications:



External Ids:

Disease Ontology 12 DOID:4730
MeSH 44 D012223
NCIt 50 C34988
SNOMED-CT 68 8229003
ICD10 33 J30.0
UMLS 72 C0035460

Summaries for Vasomotor Rhinitis

Disease Ontology : 12 A rhinitis which involves a hypersensitive reaction to various potentially irritating stimuli such as changes in weather, temperature, or barometric pressure, chemical irritants such as smoke, ozone, pollution, perfumes, and aerosol sprays, psychological stress and emotional shocks, medications, alcohol, and spicy food.

MalaCards based summary : Vasomotor Rhinitis, also known as rhinitis, vasomotor, is related to rhinitis and irritable bowel syndrome. An important gene associated with Vasomotor Rhinitis is VIP (Vasoactive Intestinal Peptide), and among its related pathways/superpathways is G alpha (s) signalling events. The drugs Histamine and Azelastine have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and heart.

Related Diseases for Vasomotor Rhinitis

Diseases related to Vasomotor Rhinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 rhinitis 32.0 VIP RNASE3
2 irritable bowel syndrome 30.1 VIP TAC1
3 bronchitis 29.4 VIP TAC1 RNASE3
4 asthma 28.0 VIP TAC1 RNASE3 IL16 CD40LG
5 allergic rhinitis 10.8
6 pollen allergy 10.5
7 chronic rhinitis 10.3
8 hypereosinophilic syndrome 10.3
9 anismus 10.3 VIP TAC1
10 wdha syndrome 10.3 VIP CALCA
11 leprosy 2 10.3 VIP CALCA
12 autonomic dysfunction 10.3
13 cluster headache 10.3 VIP CALCA
14 pancreatic cholera 10.3 VIP CALCA
15 somatostatinoma 10.3 VIP CALCA
16 gastroesophageal reflux 10.2
17 trigeminal neuralgia 10.2
18 islet cell tumor 10.2 VIP CALCA
19 retinitis pigmentosa 68 10.2 TAC1 NPS
20 epicondylitis 10.2 TAC1 NPS
21 brachial plexus lesion 10.2 TAC1 CALCA
22 dental pulp disease 10.2 TAC1 NPS
23 complex regional pain syndrome 10.2 TAC1 CALCA
24 persian gulf syndrome 10.2 VIP NPS
25 reflex sympathetic dystrophy 10.2 NPS CALCA
26 neurodermatitis 10.2 TAC1 NPS
27 indeterminate leprosy 10.1 TAC1 NPS
28 dermatitis 10.1
29 atrophic rhinitis 10.1
30 cloacogenic carcinoma 10.1 NPS CALCA
31 holoprosencephaly 3 10.1 VIP NPS
32 hemiplegia 10.1 TAC1 CALCA
33 meningoencephalitis 10.1 TAC1 CD40LG
34 alternating hemiplegia of childhood 10.1 TAC1 CALCA
35 perry syndrome 10.1 TAC1 NPS
36 ige responsiveness, atopic 10.0
37 dermatitis, atopic 10.0
38 respiratory allergy 10.0
39 xerophthalmia 10.0
40 osteomyelitis 10.0
41 tonsillitis 10.0
42 allergic hypersensitivity disease 10.0
43 keratoconjunctivitis sicca 10.0
44 urticaria 10.0
45 hyperinsulinism 10.0
46 food allergy 10.0
47 sleep disorder 10.0
48 dystonia 10.0
49 47,xyy 10.0
50 argyria 10.0

Graphical network of the top 20 diseases related to Vasomotor Rhinitis:



Diseases related to Vasomotor Rhinitis

Symptoms & Phenotypes for Vasomotor Rhinitis

Drugs & Therapeutics for Vasomotor Rhinitis

Drugs for Vasomotor Rhinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4 51-45-6 774
2
Azelastine Approved Phase 4 58581-89-8 2267
3
Montelukast Approved Phase 4 158966-92-8 5281040
4 Analgesics Phase 4
5 Neurotransmitter Agents Phase 4
6 Anti-Allergic Agents Phase 4
7 Analgesics, Non-Narcotic Phase 4
8 Olopatadine Hydrochloride Phase 4
9 Respiratory System Agents Phase 4
10 Lipoxygenase Inhibitors Phase 4
11 Anti-Inflammatory Agents, Non-Steroidal Phase 4
12 Histamine H1 Antagonists Phase 4
13
Histamine Phosphate Phase 4 51-74-1 65513
14 Histamine H1 Antagonists, Non-Sedating Phase 4
15 Anti-Inflammatory Agents Phase 4
16 Histamine Antagonists Phase 4
17 Anti-Asthmatic Agents Phase 4
18 Autonomic Agents Phase 4
19 Antirheumatic Agents Phase 4
20 Bronchodilator Agents Phase 4
21 Cytochrome P-450 Enzyme Inducers Phase 4
22 Hormones Phase 4
23 Hormone Antagonists Phase 4
24 Leukotriene Antagonists Phase 4
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
26 Vaccines Phase 4
27
Cetirizine Approved Phase 3 83881-51-0 2678
28
Ephedrine Approved Phase 3 299-42-3 9294
29
Pseudoephedrine Approved Phase 3 90-82-4 7028
30
Levocetirizine Approved Phase 3 130018-77-8 1549000
31
Oxymetazoline Approved, Investigational Phase 3 1491-59-4 4636
32
Phenylephrine Approved Phase 3 59-42-7 6041
33 Sympathomimetics Phase 3
34 Central Nervous System Stimulants Phase 3
35 Adrenergic Agents Phase 3
36 Nasal Decongestants Phase 3
37 Vasoconstrictor Agents Phase 3
38 Cardiotonic Agents Phase 3
39 Adrenergic Agonists Phase 3
40 Adrenergic alpha-Agonists Phase 3
41 Mydriatics Phase 3
42 Protective Agents Phase 3
43 Pharmaceutical Solutions Phase 3
44
Capsaicin Approved Phase 1 404-86-4 1548943
45 Peripheral Nervous System Agents Phase 1
46 Antipruritics Phase 1
47 Dermatologic Agents Phase 1
48
Esomeprazole Approved, Investigational 119141-88-7, 161796-78-7, 161973-10-0 9568614 4594
49 Gastrointestinal Agents
50 Antacids

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Olopatadine 0.6% and Azelastine 137 Mcg in Vasomotor Rhinitis Completed NCT00979615 Phase 4 Olopatadine HCL (Patanase) Nasal Spray, 0.6%;Azelastine HCl (Astelin) Nasal Spray, 137 mcg
2 The Effects of Alvokast (Montelukast) in Patients With Chronic Cough Completed NCT01754220 Phase 4 Montelukast
3 Grass Pollen Subcutaneous Immunotherapy: a Double-blind, Placebo-controlled Study in Elderly Patients With an Allergy to Grass Pollen Completed NCT02440243 Phase 4 Purethal;Purethal -placebo
4 A 4 Week Randomized, Double Blind, Placebo Controlled Study of GW685698X Aq Nasal Spray 100mcg QD in Adults and Adolescents With Vasomotor Rhinitis Completed NCT00118703 Phase 3 GW685698X
5 A 4 Week Randomized, Double Blind, Placebo Controlled Study of GW685698X Aq Nasal Spray 100mcg QD in Adults and Adolescents With Vasomotor Rhinitis Completed NCT00117325 Phase 3 GW685698X
6 Efficacy and Safety of Cossac L Tablet in Vasomotor Rhinitis Patients : A Randomized, Double-blind, Placebo-controlled, Phase 3 Clinical Trial Completed NCT01509209 Phase 3 Pseudoephedrine / Levocetirizine
7 Impact of Acupuncture on Vasomotor Rhinitis: a Randomised Placebo Controlled Pilot Study Completed NCT00682162 Phase 3
8 A Randomized, Two-Way Crossover, Multicenter, Consumer Preference Study of Two Oral Formulations of Phenylephrine Hydrochloride. Completed NCT00976209 Phase 3 Phenylephrine Hydrochloride (HCl) Extended Release (ER) Tablets 30 mg;Phenylephrine Hydrochloride (HCl) Immediate Release (IR) tablets, 10 mg
9 Phase III Randomized Open-label Clinical Trial Comparing Cleanoze® Irrigation Device With Powder Preparation Versus Conventional Irrigation Method for Chronic Rhinitis Completed NCT02763241 Phase 3 Cleanoze®;Saline (Syringe irrigation)
10 Tolerability of Intranasal Capsaicinoid Spray Recruiting NCT03952845 Phase 1
11 Efficacy of Esomeprazole for Non-Allergic Rhinitis: A Double-blind, Placebo Controlled Trial Completed NCT00745849 esomeprazole;placebo
12 Nasal Physiologic Reactivity of Nonallergic Rhinitics to Cold Air Provocation Completed NCT00415493
13 Nasal Saline Irrigation After Radiation Therapy for Oropharyngeal Cancer: A Pilot Study Completed NCT02338102
14 Reproducibility of Cell Counts in Nasal Lavage: A Comparison of Pooled Versus Non-Pooled Nasal Lavage Samples Completed NCT00229190
15 DUAL BRAVO PH MONITORING: A Feasibility Trial Completed NCT00378898

Search NIH Clinical Center for Vasomotor Rhinitis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


azelastine
Azelastine
Azelastine hydrochloride
Beclomethasone dipropionate
Brompheniramine
Brompheniramine Maleate
Budesonide
carbinoxamine
Carbinoxamine
Carbinoxamine maleate
Cyproheptadine
Dexchlorpheniramine maleate
Ipratropium
Ipratropium Bromide
Phenylephrine
Phenylephrine bitartrate
Phenylephrine Hydrochloride
Phenylephrine Tannate
Phenylpropanolamine Hydrochloride
Promethazine
Scopolamine
Scopolamine Hydrobromide
tetrahydrozoline
Tetrahydrozoline hydrochloride
Triprolidine

Cochrane evidence based reviews: rhinitis, vasomotor

Genetic Tests for Vasomotor Rhinitis

Anatomical Context for Vasomotor Rhinitis

MalaCards organs/tissues related to Vasomotor Rhinitis:

41
Testes, Skin, Heart, Thyroid, Cortex, Adrenal Cortex, Tonsil

Publications for Vasomotor Rhinitis

Articles related to Vasomotor Rhinitis:

(show top 50) (show all 646)
# Title Authors PMID Year
1
[The roles of three peptides in the pathogenesis of vasomotor rhinitis]. 9 38
17087112 2006
2
Eosinophil inflammation of the nasal mucosa in allergic and non-allergic rhinitis measured by eosinophil cationic protein levels in native nasal fluid and serum. 9 38
7889429 1994
3
[Application of nasal saline irrigation in nasal inflammatory diseases]. 38
30669208 2019
4
[Therapeutic effect of nasal corticosteroids combined with nasal antihistamine on vasomotor rhinitis]. 38
30550209 2018
5
Cryotherapy for the Treatment of Chronic Rhinitis: A Qualitative Systematic Review. 38
30229670 2018
6
Surgical Management of Nonallergic Rhinitis. 38
29937065 2018
7
[Treatment of allergic and vasomotor rhinitis: the role of beclomethasone dipropionate and hyaluronic acid (with high molecular weight).] 38
29689043 2018
8
[Cryosurgery in the treatment of allergic and non-allergic rhinitis]. 38
30267489 2018
9
[Innovative technology full volume lavage of the nasal cavity in the treatment of allergic and vasomotor rhinitis]. 38
30412178 2018
10
[A variant of the modification of the rhinosurgical intervention with the use of the hemostatic glue]. 38
30412179 2018
11
[Research advances of pregnancy rhinitis]. 38
29798199 2017
12
Prognostic value of nasal cytology and clinical factors in nasal polyps development in patients at risk: can the beginning predict the end? 38
28665504 2017
13
[Clinical symptoms and immunology inspection characteristics of nasal cavity local allergy]. 38
29798346 2017
14
[Nasal irrigation for the treatment of vasomotor rhinitis: a pilot study]. 38
28635218 2017
15
[Nasal turbinate surgery]. 38
28401248 2017
16
Nasal Muco-ciliary transport time alteration: efficacy of 18 B Glycyrrhetinic acid. 38
29209499 2017
17
A Pilot Study Investigating Clinical Responses and Biological Pathways of Azelastine/Fluticasone in Nonallergic Vasomotor Rhinitis before and after Cold Dry Air Provocation. 38
28787742 2017
18
Combination therapy in allergic rhinitis: What works and what does not work. 38
28124648 2016
19
Severity of nasal obstruction can predict the anxiety status of patients with allergic rhinitis but not patients with vasomotor rhinitis. 38
27277070 2016
20
Is the location of a septal deviation associated with the degree of postoperative pain after septoplasty? 38
27792832 2016
21
Inferior Turbinate Hypertrophy in Rhinoplasty: Systematic Review of Surgical Techniques. 38
27556616 2016
22
Pathogenesis of rhinitis. 38
27434218 2016
23
NASAL cytology: practical aspects and clinical relevance. 38
27009397 2016
24
Nonallergic Rhinitis: Treatment. 38
27083104 2016
25
[Acute respiratory viral infections: Topical issues of diagnosis, prevention and treatment in therapeutic practice]. 38
28005035 2016
26
[About the unresolved problems of terminology and classification of allergic rhinitis and the desirability of distinguishing the mixed form of the disease]. 38
27876734 2016
27
Association between vasomotor rhinitis and irritable bowel syndrome. 38
28683253 2016
28
Vitamin D serum levels in children with allergic and vasomotor rhinitis. 38
26512257 2015
29
Endoscopic vidian neurectomy: a prospective case series. 38
25732231 2015
30
Surgical management of vasomotor rhinitis: a systematic review. 38
25785754 2015
31
[The disturbances of vegetative homeostasis in the children suffering from vasomotor rhinitis]. 38
26145742 2015
32
[The modern approach to the treatment of the patients presenting with vasomotor rhinitis with the use of the electrosurgical technique]. 38
26145748 2015
33
"Overlapped" rhinitis: a real trap for rhinoallergologists. 38
25398169 2014
34
[The topical treatment of allergic and vasomotor rhinitis: the role of beclomethasone dipropionate]. 38
25424236 2014
35
Rhinorrhea triggered by obturator prosthesis after surgical intervention of partial maxillary resection: a clinical report. 38
25503096 2014
36
[Diagnosis and clinical characteristics of patients with non-allergic rhinitis]. 38
25241870 2014
37
Long-term, randomized safety study of MP29-02 (a novel intranasal formulation of azelastine hydrochloride and fluticasone propionate in an advanced delivery system) in subjects with chronic rhinitis. 38
24607046 2014
38
Therapeutic effectiveness of endoscopic vidian neurectomy for the treatment of vasomotor rhinitis. 38
24433056 2014
39
[The clinical and functional evaluation of the combined treatment of vasomotor rhinitis in the children]. 38
25377674 2014
40
Intranasal capsaicin in management of nonallergic (vasomotor) rhinitis. 38
24941668 2014
41
High-content pSTAT3/1 imaging assays to screen for selective inhibitors of STAT3 pathway activation in head and neck cancer cell lines. 38
24127660 2014
42
[Suggestion on the diagnosis and treatment of vasomotor rhinitis]. 38
24444630 2013
43
Effect of intranasal azelastine on substance P release in perennial nonallergic rhinitis patients. 38
24274229 2013
44
MP29-02: a breakthrough for the treatment of allergic rhinitis. 38
23977840 2013
45
Endoscopic vidian neurectomy assisted by power instrumentation and coblation. 38
23806808 2013
46
Nonallergic rhinitis: therapeutic options. 38
23756873 2013
47
Sneezing and runny nose: should allergy testing be routinely performed? 38
24427659 2013
48
Chapter 14: Nonallergic rhinitis. 38
23711042 2013
49
Chapter 14: Nonallergic rhinitis. 38
29021040 2013
50
When sneezing indicates the cell type. 38
23193018 2013

Variations for Vasomotor Rhinitis

Expression for Vasomotor Rhinitis

Search GEO for disease gene expression data for Vasomotor Rhinitis.

Pathways for Vasomotor Rhinitis

Pathways related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.96 VIP NPS CALCA

GO Terms for Vasomotor Rhinitis

Cellular components related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 TAC1 RNASE3 IL16 CD40LG CALCA
2 extracellular region GO:0005576 9.17 VIP TAC1 RNASE3 NPS IL16 CD40LG

Biological processes related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.78 VIP TAC1 NPS CALCA
2 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.49 VIP CALCA
3 regulation of blood pressure GO:0008217 9.46 TAC1 CALCA
4 inflammatory response GO:0006954 9.43 TAC1 CD40LG
5 leukocyte cell-cell adhesion GO:0007159 9.37 CD40LG CALCA
6 positive regulation of blood vessel diameter GO:0097755 9.32 VIP CALCA
7 positive regulation of synaptic transmission, GABAergic GO:0032230 9.16 TAC1 NPS
8 cellular response to nerve growth factor stimulus GO:1990090 9.1 TAC1
9 response to pain GO:0048265 8.96 TAC1
10 neuropeptide signaling pathway GO:0007218 8.96 TAC1 NPS
11 positive regulation of action potential GO:0045760 8.62 TAC1 NPS

Molecular functions related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 VIP CALCA

Sources for Vasomotor Rhinitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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