MCID: VSM001
MIFTS: 37

Vasomotor Rhinitis

Categories: Respiratory diseases

Aliases & Classifications for Vasomotor Rhinitis

MalaCards integrated aliases for Vasomotor Rhinitis:

Name: Vasomotor Rhinitis 12 15 17 32
Rhinitis, Vasomotor 43 71
Rhinitis Vasomotor 54

Classifications:



External Ids:

Disease Ontology 12 DOID:4730
MeSH 43 D012223
NCIt 49 C34988
SNOMED-CT 67 8229003
ICD10 32 J30.0
UMLS 71 C0035460

Summaries for Vasomotor Rhinitis

Disease Ontology : 12 A rhinitis which involves a hypersensitive reaction to various potentially irritating stimuli such as changes in weather, temperature, or barometric pressure, chemical irritants such as smoke, ozone, pollution, perfumes, and aerosol sprays, psychological stress and emotional shocks, medications, alcohol, and spicy food.

MalaCards based summary : Vasomotor Rhinitis, also known as rhinitis, vasomotor, is related to rhinitis and allergic rhinitis. An important gene associated with Vasomotor Rhinitis is VIP (Vasoactive Intestinal Peptide), and among its related pathways/superpathways are Peptide ligand-binding receptors and G alpha (s) signalling events. The drugs Histamine and Azelastine have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and skin.

Related Diseases for Vasomotor Rhinitis

Diseases related to Vasomotor Rhinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 rhinitis 31.9 VIP RNASE3 NPY
2 allergic rhinitis 31.2 VIP RNASE3 IL16
3 chronic rhinitis 30.6 TAC1 RNASE3 NPS
4 irritable bowel syndrome 29.9 VIP TRPV1 TAC1
5 trigeminal neuralgia 29.8 TRPV1 TAC1 NPS CALCA
6 dermatitis 29.8 RNASE3 IL16 CMA1
7 bronchitis 29.6 VIP TAC1 RNASE3 CD40LG CALCA
8 urticaria 29.5 RNASE3 CMA1 CD40LG
9 dermatitis, atopic 28.1 VIP TAC1 RNASE3 NPS IL16 CMA1
10 asthma 27.2 VIP TRPV1 TAC1 RNASE3 NPY IL16
11 pollen allergy 10.5
12 neurogenic bowel 10.4 VIP TAC1
13 pancreatic cholera 10.4 VIP CALCA
14 cluster headache 10.4 VIP CALCA
15 hypereosinophilic syndrome 10.3
16 autonomic nervous system benign neoplasm 10.3 VIP CALCA
17 prurigo nodularis 10.3 TAC1 RNASE3
18 peripheral nervous system benign neoplasm 10.3 VIP CALCA
19 autonomic dysfunction 10.3
20 nerve compression syndrome 10.3 TAC1 CALCA
21 aids phobia 10.3 TAC1 NPS
22 persian gulf syndrome 10.3 VIP NPS
23 raynaud disease 10.3 CD40LG CALCA
24 retinitis pigmentosa 68 10.3 TAC1 NPS
25 maxillary sinusitis 10.3 RNASE3 CD40LG
26 toxocariasis 10.2 RNASE3 CD40LG
27 erysipelas 10.2 CD40LG CALCA
28 gastroesophageal reflux 10.2
29 somatostatinoma 10.2 VIP CALCA
30 cryptosporidiosis 10.2 VIP TAC1 CD40LG
31 impetigo 10.2 CD40LG CALCA
32 carcinoid syndrome 10.2 NPY CALCA
33 intussusception 10.2 VIP CD40LG
34 henoch-schoenlein purpura 10.1 RNASE3 CD40LG
35 viral meningitis 10.1 IL16 CD40LG CALCA
36 atrophic rhinitis 10.1
37 vipoma 10.1 VIP CALCA
38 carbamazepine allergy 10.1 TAC1 NPS CALCA
39 causalgia 10.1 TAC1 NPS CALCA
40 epicondylitis 10.1 TAC1 NPS CALCA
41 detrusor sphincter dyssynergia 10.1 TRPV1 TAC1
42 nose disease 10.1 TAC1 RNASE3 CD40LG
43 subungual glomus tumor 10.1 TRPV1 TAC1
44 bronchial disease 10.1 TAC1 RNASE3 CD40LG
45 collagenous colitis 10.1 RNASE3 CD40LG
46 chronic cystitis 10.1 TRPV1 TAC1
47 viral laryngitis 10.1 TRPV1 CD40LG
48 leprosy 2 10.1 VIP NPY CALCA
49 diarrhea 10.0 TAC1 CD40LG CALCA
50 complex regional pain syndrome 10.0 TAC1 NPY CALCA

Graphical network of the top 20 diseases related to Vasomotor Rhinitis:



Diseases related to Vasomotor Rhinitis

Symptoms & Phenotypes for Vasomotor Rhinitis

Drugs & Therapeutics for Vasomotor Rhinitis

Drugs for Vasomotor Rhinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4 51-45-6 774
2
Azelastine Approved Phase 4 58581-89-8 2267
3
Montelukast Approved Phase 4 158966-92-8 5281040
4 Anti-Inflammatory Agents Phase 4
5 Respiratory System Agents Phase 4
6 Analgesics, Non-Narcotic Phase 4
7 Neurotransmitter Agents Phase 4
8 Anti-Asthmatic Agents Phase 4
9 Analgesics Phase 4
10 Olopatadine Hydrochloride Phase 4
11 Histamine Antagonists Phase 4
12 Histamine H1 Antagonists Phase 4
13 Anti-Inflammatory Agents, Non-Steroidal Phase 4
14 Bronchodilator Agents Phase 4
15 Antirheumatic Agents Phase 4
16 Autonomic Agents Phase 4
17 Anti-Allergic Agents Phase 4
18 Histamine H1 Antagonists, Non-Sedating Phase 4
19
Histamine Phosphate Phase 4 51-74-1 65513
20 Hormone Antagonists Phase 4
21 Leukotriene Antagonists Phase 4
22 Hormones Phase 4
23 Vaccines Phase 4
24
Ephedrine Approved Phase 3 299-42-3 9294
25
Cetirizine Approved Phase 3 83881-51-0 2678
26
Pseudoephedrine Approved Phase 3 90-82-4 7028
27
Levocetirizine Approved Phase 3 130018-77-8 1549000
28
Oxymetazoline Approved, Investigational Phase 3 1491-59-4 4636
29
Phenylephrine Approved Phase 3 59-42-7 6041
30 Central Nervous System Stimulants Phase 3
31 Sympathomimetics Phase 3
32 Nasal Decongestants Phase 3
33 Vasoconstrictor Agents Phase 3
34 Adrenergic Agents Phase 3
35 Adrenergic Agonists Phase 3
36 Protective Agents Phase 3
37 Mydriatics Phase 3
38 Pharmaceutical Solutions Phase 3
39
Capsaicin Approved Phase 1 404-86-4 1548943
40 Dermatologic Agents Phase 1
41 Antipruritics Phase 1
42
Esomeprazole Approved, Investigational 161973-10-0, 161796-78-7, 119141-88-7 4594 9568614
43
Isotretinoin Approved 4759-48-2 5282379 5538
44 Gastrointestinal Agents
45 Anti-Ulcer Agents
46 Antacids
47 Proton Pump Inhibitors
48 Liver Extracts

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Olopatadine 0.6% and Azelastine 137 Mcg in Vasomotor Rhinitis Completed NCT00979615 Phase 4 Olopatadine HCL (Patanase) Nasal Spray, 0.6%;Azelastine HCl (Astelin) Nasal Spray, 137 mcg
2 The Effects of Alvokast (Montelukast) in Patients With Chronic Cough Completed NCT01754220 Phase 4 Montelukast
3 Grass Pollen Subcutaneous Immunotherapy: a Double-blind, Placebo-controlled Study in Elderly Patients With an Allergy to Grass Pollen Completed NCT02440243 Phase 4 Purethal;Purethal -placebo
4 A 4 Week Randomized, Double Blind, Placebo Controlled Study of GW685698X Aq Nasal Spray 100mcg QD in Adults and Adolescents With Vasomotor Rhinitis Completed NCT00118703 Phase 3 GW685698X
5 A 4 Week Randomized, Double Blind, Placebo Controlled Study of GW685698X Aq Nasal Spray 100mcg QD in Adults and Adolescents With Vasomotor Rhinitis Completed NCT00117325 Phase 3 GW685698X
6 Efficacy and Safety of Cossac L Tablet in Vasomotor Rhinitis Patients : A Randomized, Double-blind, Placebo-controlled, Phase 3 Clinical Trial Completed NCT01509209 Phase 3 Pseudoephedrine / Levocetirizine
7 Impact of Acupuncture on Vasomotor Rhinitis: a Randomised Placebo Controlled Pilot Study Completed NCT00682162 Phase 3
8 A Randomized, Two-Way Crossover, Multicenter, Consumer Preference Study of Two Oral Formulations of Phenylephrine Hydrochloride. Completed NCT00976209 Phase 3 Phenylephrine Hydrochloride (HCl) Extended Release (ER) Tablets 30 mg;Phenylephrine Hydrochloride (HCl) Immediate Release (IR) tablets, 10 mg
9 Phase III Randomized Open-label Clinical Trial Comparing Cleanoze® Irrigation Device With Powder Preparation Versus Conventional Irrigation Method for Chronic Rhinitis Completed NCT02763241 Phase 3 Cleanoze®;Saline (Syringe irrigation)
10 Tolerability of Intranasal Capsaicinoid Spray Recruiting NCT03952845 Phase 1
11 Efficacy of Esomeprazole for Non-Allergic Rhinitis: A Double-blind, Placebo Controlled Trial Completed NCT00745849 esomeprazole;placebo
12 Nasal Physiologic Reactivity of Nonallergic Rhinitics to Cold Air Provocation Completed NCT00415493
13 Nasal Saline Irrigation After Radiation Therapy for Oropharyngeal Cancer: A Pilot Study Completed NCT02338102
14 Reproducibility of Cell Counts in Nasal Lavage: A Comparison of Pooled Versus Non-Pooled Nasal Lavage Samples Completed NCT00229190
15 DUAL BRAVO PH MONITORING: A Feasibility Trial Completed NCT00378898
16 Treatment of Acne Vulgaris Using 1,565 nm Non-ablative Fractional Laser in Combination With Isotretinoin and Pricking Blood Therapy Completed NCT04156815 Oral isotretinoin

Search NIH Clinical Center for Vasomotor Rhinitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


azelastine
Azelastine hydrochloride
Brompheniramine
Brompheniramine Maleate
carbinoxamine
Carbinoxamine maleate
Ipratropium
Ipratropium Bromide
Phenylephrine
Phenylephrine bitartrate
Phenylephrine Hydrochloride
Phenylephrine Tannate
Phenylpropanolamine Hydrochloride
Scopolamine
Scopolamine Hydrobromide
tetrahydrozoline
Tetrahydrozoline hydrochloride

Cochrane evidence based reviews: rhinitis, vasomotor

Genetic Tests for Vasomotor Rhinitis

Anatomical Context for Vasomotor Rhinitis

MalaCards organs/tissues related to Vasomotor Rhinitis:

40
Testes, Liver, Skin, Cortex, Heart, Thyroid, Tonsil

Publications for Vasomotor Rhinitis

Articles related to Vasomotor Rhinitis:

(show top 50) (show all 651)
# Title Authors PMID Year
1
[The roles of three peptides in the pathogenesis of vasomotor rhinitis]. 61 54
17087112 2006
2
Eosinophil inflammation of the nasal mucosa in allergic and non-allergic rhinitis measured by eosinophil cationic protein levels in native nasal fluid and serum. 61 54
7889429 1994
3
Rhinorrhea as a Result of Alzheimer's Disease Treatment: A Case Report. 61
31818352 2019
4
Asthma and allergies in pregnancy. 61
31690383 2019
5
Intranasal corticosteroids for non-allergic rhinitis. 61
31677153 2019
6
Allergic and nonallergic rhinitis. 61
31690374 2019
7
[Endoscopic posterior nasal neurectomy]. 61
31439065 2019
8
[Application of nasal saline irrigation in nasal inflammatory diseases]. 61
30669208 2019
9
[Therapeutic effect of nasal corticosteroids combined with nasal antihistamine on vasomotor rhinitis]. 61
30550209 2018
10
Cryotherapy for the Treatment of Chronic Rhinitis: A Qualitative Systematic Review. 61
30229670 2018
11
Surgical Management of Nonallergic Rhinitis. 61
29937065 2018
12
[Treatment of allergic and vasomotor rhinitis: the role of beclomethasone dipropionate and hyaluronic acid (with high molecular weight).] 61
29689043 2018
13
[Cryosurgery in the treatment of allergic and non-allergic rhinitis]. 61
30267489 2018
14
[Innovative technology full volume lavage of the nasal cavity in the treatment of allergic and vasomotor rhinitis]. 61
30412178 2018
15
[A variant of the modification of the rhinosurgical intervention with the use of the hemostatic glue]. 61
30412179 2018
16
[Research advances of pregnancy rhinitis]. 61
29798199 2017
17
Prognostic value of nasal cytology and clinical factors in nasal polyps development in patients at risk: can the beginning predict the end? 61
28665504 2017
18
[Clinical symptoms and immunology inspection characteristics of nasal cavity local allergy]. 61
29798346 2017
19
[Nasal irrigation for the treatment of vasomotor rhinitis: a pilot study]. 61
28635218 2017
20
[Nasal turbinate surgery]. 61
28401248 2017
21
Nasal Muco-ciliary transport time alteration: efficacy of 18 B Glycyrrhetinic acid. 61
29209499 2017
22
A Pilot Study Investigating Clinical Responses and Biological Pathways of Azelastine/Fluticasone in Nonallergic Vasomotor Rhinitis before and after Cold Dry Air Provocation. 61
28787742 2017
23
Combination therapy in allergic rhinitis: What works and what does not work. 61
28124648 2016
24
Severity of nasal obstruction can predict the anxiety status of patients with allergic rhinitis but not patients with vasomotor rhinitis. 61
27277070 2016
25
Is the location of a septal deviation associated with the degree of postoperative pain after septoplasty? 61
27792832 2016
26
Inferior Turbinate Hypertrophy in Rhinoplasty: Systematic Review of Surgical Techniques. 61
27556616 2016
27
Pathogenesis of rhinitis. 61
27434218 2016
28
NASAL cytology: practical aspects and clinical relevance. 61
27009397 2016
29
Nonallergic Rhinitis: Treatment. 61
27083104 2016
30
[Acute respiratory viral infections: Topical issues of diagnosis, prevention and treatment in therapeutic practice]. 61
28005035 2016
31
[About the unresolved problems of terminology and classification of allergic rhinitis and the desirability of distinguishing the mixed form of the disease]. 61
27876734 2016
32
Association between vasomotor rhinitis and irritable bowel syndrome. 61
28683253 2016
33
Vitamin D serum levels in children with allergic and vasomotor rhinitis. 61
26512257 2015
34
Endoscopic vidian neurectomy: a prospective case series. 61
25732231 2015
35
Surgical management of vasomotor rhinitis: a systematic review. 61
25785754 2015
36
[The disturbances of vegetative homeostasis in the children suffering from vasomotor rhinitis]. 61
26145742 2015
37
[The modern approach to the treatment of the patients presenting with vasomotor rhinitis with the use of the electrosurgical technique]. 61
26145748 2015
38
"Overlapped" rhinitis: a real trap for rhinoallergologists. 61
25398169 2014
39
[The topical treatment of allergic and vasomotor rhinitis: the role of beclomethasone dipropionate]. 61
25424236 2014
40
Rhinorrhea triggered by obturator prosthesis after surgical intervention of partial maxillary resection: a clinical report. 61
25503096 2014
41
[Diagnosis and clinical characteristics of patients with non-allergic rhinitis]. 61
25241870 2014
42
Long-term, randomized safety study of MP29-02 (a novel intranasal formulation of azelastine hydrochloride and fluticasone propionate in an advanced delivery system) in subjects with chronic rhinitis. 61
24607046 2014
43
Therapeutic effectiveness of endoscopic vidian neurectomy for the treatment of vasomotor rhinitis. 61
24433056 2014
44
[The clinical and functional evaluation of the combined treatment of vasomotor rhinitis in the children]. 61
25377674 2014
45
Intranasal capsaicin in management of nonallergic (vasomotor) rhinitis. 61
24941668 2014
46
High-content pSTAT3/1 imaging assays to screen for selective inhibitors of STAT3 pathway activation in head and neck cancer cell lines. 61
24127660 2014
47
[Suggestion on the diagnosis and treatment of vasomotor rhinitis]. 61
24444630 2013
48
Effect of intranasal azelastine on substance P release in perennial nonallergic rhinitis patients. 61
24274229 2013
49
MP29-02: a breakthrough for the treatment of allergic rhinitis. 61
23977840 2013
50
Endoscopic vidian neurectomy assisted by power instrumentation and coblation. 61
23806808 2013

Variations for Vasomotor Rhinitis

Expression for Vasomotor Rhinitis

Search GEO for disease gene expression data for Vasomotor Rhinitis.

Pathways for Vasomotor Rhinitis

GO Terms for Vasomotor Rhinitis

Cellular components related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 TAC1 RNASE3 NPY IL16 CMA1 CD40LG
2 extracellular region GO:0005576 9.28 VIP TAC1 RNASE3 NPY NPS IL16

Biological processes related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.85 CALCA NPS NPY OR10A2 TAC1 VIP
2 inflammatory response GO:0006954 9.78 CALCA CD40LG TAC1 TRPV1
3 positive regulation of cytosolic calcium ion concentration GO:0007204 9.67 CALCA TAC1 TRPV1
4 feeding behavior GO:0007631 9.54 CALCA NPY
5 leukocyte cell-cell adhesion GO:0007159 9.52 CALCA CD40LG
6 positive regulation of blood vessel diameter GO:0097755 9.51 CALCA VIP
7 regulation of blood pressure GO:0008217 9.5 TAC1 NPY CALCA
8 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.46 CALCA TRPV1
9 negative regulation of heart rate GO:0010459 9.43 TAC1 TRPV1
10 positive regulation of synaptic transmission, GABAergic GO:0032230 9.4 NPS TAC1
11 cellular response to nerve growth factor stimulus GO:1990090 9.33 TRPV1 TAC1 CALCA
12 positive regulation of action potential GO:0045760 9.26 TAC1 NPS
13 neuropeptide signaling pathway GO:0007218 9.26 TAC1 NPY NPS CALCA
14 response to pain GO:0048265 8.8 TRPV1 TAC1 CALCA

Molecular functions related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 8.96 VIP NPY
2 hormone activity GO:0005179 8.8 VIP NPY CALCA

Sources for Vasomotor Rhinitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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