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MCID: VSM001
MIFTS: 38

Vasomotor Rhinitis

Categories: Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Vasomotor Rhinitis

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MalaCards integrated aliases for Vasomotor Rhinitis:

Name: Vasomotor Rhinitis 12 15 17 32
Rhinitis, Vasomotor 43 71
Rhinitis Vasomotor 54

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:4730
MeSH 43 D012223
NCIt 49 C34988
SNOMED-CT 67 8229003
ICD10 32 J30.0
UMLS 71 C0035460
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Summaries for Vasomotor Rhinitis

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Disease Ontology : 12 A rhinitis which involves a hypersensitive reaction to various potentially irritating stimuli such as changes in weather, temperature, or barometric pressure, chemical irritants such as smoke, ozone, pollution, perfumes, and aerosol sprays, psychological stress and emotional shocks, medications, alcohol, and spicy food.

MalaCards based summary : Vasomotor Rhinitis, also known as rhinitis, vasomotor, is related to chronic rhinitis and rhinitis. An important gene associated with Vasomotor Rhinitis is VIP (Vasoactive Intestinal Peptide), and among its related pathways/superpathways are Peptide ligand-binding receptors and G alpha (s) signalling events. The drugs Histamine and Azelastine have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and skin.

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Related Diseases for Vasomotor Rhinitis

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Diseases related to Vasomotor Rhinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)
# Related Disease Score Top Affiliating Genes
1 chronic rhinitis 30.5 TAC1 RNASE3 IL5
2 rhinitis 30.5 VIP RNASE3 NPY KNG1 IL5
3 allergic rhinitis 30.0 VIP TAC1 RNASE3 KNG1 IL5 IL16
4 irritable bowel syndrome 30.0 VIP TRPV1 TAC1
5 urticaria 29.9 RNASE3 IL5 CD40LG
6 trigeminal neuralgia 29.9 TRPV1 TAC1 NPS CALCA
7 gastroesophageal reflux 29.8 VIP NPY IL5
8 allergic hypersensitivity disease 29.4 TAC1 RNASE3 KNG1 IL5
9 bronchitis 29.1 VIP TAC1 RNASE3 IL5 CD40LG CALCA
10 dermatitis, atopic 28.9 VIP TAC1 RNASE3 NPS IL5 IL16
11 asthma 26.8 VIP TRPV1 TAC1 RNASE3 NPY KNG1
12 pollen allergy 10.5
13 pancreatic somatostatinoma 10.4 VIP CALCA
14 somatostatinoma 10.4 VIP CALCA
15 endometrial small cell carcinoma 10.4 VIP TAC1
16 pancreatic cholera 10.4 VIP CALCA
17 endocrine pancreas disease 10.4 VIP CALCA
18 cluster headache 10.4 VIP CALCA
19 colon neuroendocrine neoplasm 10.4 VIP CALCA
20 paralytic ileus 10.4 VIP TAC1
21 prurigo nodularis 10.4 TAC1 RNASE3
22 functional gastric disease 10.3 VIP TAC1
23 autonomic nervous system benign neoplasm 10.3 VIP CALCA
24 hypereosinophilic syndrome 10.3
25 peripheral nervous system benign neoplasm 10.3 VIP CALCA
26 persian gulf syndrome 10.3 VIP NPS
27 neurodermatitis 10.3 TAC1 NPS
28 anisakiasis 10.3 RNASE3 CD40LG
29 aids phobia 10.3 TAC1 NPS
30 autonomic dysfunction 10.3
31 raynaud disease 10.3 CD40LG CALCA
32 maxillary sinusitis 10.3 RNASE3 CD40LG
33 erysipelas 10.3 CD40LG CALCA
34 cryptosporidiosis 10.2 VIP TAC1 CD40LG
35 interval angle-closure glaucoma 10.2 TAC1 KNG1
36 norwegian scabies 10.2 IL5 CD40LG
37 whiplash 10.2 KNG1 IL16
38 mikulicz disease 10.2 IL5 CD40LG
39 trichinosis 10.2 IL5 CD40LG
40 impetigo 10.2 CD40LG CALCA
41 viral meningitis 10.2 IL16 CD40LG CALCA
42 loeffler endocarditis 10.2 RNASE3 IL5
43 hyperhidrosis, gustatory 10.2 TRPV1 TAC1
44 pustulosis palmaris et plantaris 10.2 IL5 CD40LG
45 bursitis 10.2 TAC1 KNG1
46 atopic keratoconjunctivitis 10.2 RNASE3 IL5
47 carbamazepine allergy 10.2 TAC1 NPS CALCA
48 mite infestation 10.2 IL5 CD40LG
49 epicondylitis 10.2 TAC1 NPS CALCA
50 algoneurodystrophy 10.1 TAC1 NPS CALCA

Graphical network of the top 20 diseases related to Vasomotor Rhinitis:



Diseases related to Vasomotor Rhinitis
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Symptoms & Phenotypes for Vasomotor Rhinitis

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Drugs & Therapeutics for Vasomotor Rhinitis

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Drugs for Vasomotor Rhinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4 51-45-6 774
2
Azelastine Approved Phase 4 58581-89-8 2267
3
Montelukast Approved Phase 4 158966-92-8 5281040
4 Analgesics, Non-Narcotic Phase 4
5 Olopatadine Hydrochloride Phase 4
6 Respiratory System Agents Phase 4
7 Neurotransmitter Agents Phase 4
8 Anti-Asthmatic Agents Phase 4
9 Anti-Allergic Agents Phase 4
10 Histamine H1 Antagonists Phase 4
11 Histamine H1 Antagonists, Non-Sedating Phase 4
12 Histamine Antagonists Phase 4
13
Histamine Phosphate Phase 4 51-74-1 65513
14 Analgesics Phase 4
15 Anti-Inflammatory Agents Phase 4
16 Bronchodilator Agents Phase 4
17 Anti-Inflammatory Agents, Non-Steroidal Phase 4
18 Antirheumatic Agents Phase 4
19 Hormone Antagonists Phase 4
20 Leukotriene Antagonists Phase 4
21 Hormones Phase 4
22 Vaccines Phase 4
23 Immunologic Factors Phase 4
24
Levocetirizine Approved Phase 3 130018-77-8 1549000
25
Pseudoephedrine Approved Phase 3 90-82-4 7028
26
Ephedrine Approved Phase 3 299-42-3 9294
27
Phenylephrine Approved Phase 3 59-42-7 6041
28
Oxymetazoline Approved, Investigational Phase 3 1491-59-4 4636
29 Central Nervous System Stimulants Phase 3
30 Nasal Decongestants Phase 3
31 Adrenergic Agents Phase 3
32 Vasoconstrictor Agents Phase 3
33 Sympathomimetics Phase 3
34 Adrenergic alpha-Agonists Phase 3
35 Cardiotonic Agents Phase 3
36 Adrenergic Agonists Phase 3
37 Protective Agents Phase 3
38 Mydriatics Phase 3
39 Pharmaceutical Solutions Phase 3
40
Capsaicin Approved Phase 1 404-86-4 1548943
41
Esomeprazole Approved, Investigational 161796-78-7, 119141-88-7, 161973-10-0 9568614 4594
42
Isotretinoin Approved 4759-48-2 5282379 5538
43 Antacids
44 Anti-Ulcer Agents
45 Gastrointestinal Agents
46 Proton Pump Inhibitors
47 Dermatologic Agents
48 Liver Extracts

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Olopatadine 0.6% and Azelastine 137 Mcg in Vasomotor Rhinitis Completed NCT00979615 Phase 4 Olopatadine HCL (Patanase) Nasal Spray, 0.6%;Azelastine HCl (Astelin) Nasal Spray, 137 mcg
2 The Effects of Alvokast (Montelukast) in Patients With Chronic Cough Completed NCT01754220 Phase 4 Montelukast
3 Grass Pollen Subcutaneous Immunotherapy: a Double-blind, Placebo-controlled Study in Elderly Patients With an Allergy to Grass Pollen Completed NCT02440243 Phase 4 Purethal;Purethal -placebo
4 A 4 Week Randomized, Double Blind, Placebo Controlled Study of GW685698X Aq Nasal Spray 100mcg QD in Adults and Adolescents With Vasomotor Rhinitis Completed NCT00118703 Phase 3 GW685698X
5 A 4 Week Randomized, Double Blind, Placebo Controlled Study of GW685698X Aq Nasal Spray 100mcg QD in Adults and Adolescents With Vasomotor Rhinitis Completed NCT00117325 Phase 3 GW685698X
6 Efficacy and Safety of Cossac L Tablet in Vasomotor Rhinitis Patients : A Randomized, Double-blind, Placebo-controlled, Phase 3 Clinical Trial Completed NCT01509209 Phase 3 Pseudoephedrine / Levocetirizine
7 Impact of Acupuncture on Vasomotor Rhinitis: a Randomised Placebo Controlled Pilot Study Completed NCT00682162 Phase 3
8 A Randomized, Two-Way Crossover, Multicenter, Consumer Preference Study of Two Oral Formulations of Phenylephrine Hydrochloride. Completed NCT00976209 Phase 3 Phenylephrine Hydrochloride (HCl) Extended Release (ER) Tablets 30 mg;Phenylephrine Hydrochloride (HCl) Immediate Release (IR) tablets, 10 mg
9 Phase III Randomized Open-label Clinical Trial Comparing Cleanoze® Irrigation Device With Powder Preparation Versus Conventional Irrigation Method for Chronic Rhinitis Completed NCT02763241 Phase 3 Cleanoze®;Saline (Syringe irrigation)
10 Tolerability of Intranasal Capsaicinoid Spray Recruiting NCT03952845 Phase 1
11 Efficacy of Esomeprazole for Non-Allergic Rhinitis: A Double-blind, Placebo Controlled Trial Completed NCT00745849 esomeprazole;placebo
12 Nasal Physiologic Reactivity of Nonallergic Rhinitics to Cold Air Provocation Completed NCT00415493
13 Nasal Saline Irrigation After Radiation Therapy for Oropharyngeal Cancer: A Pilot Study Completed NCT02338102
14 Reproducibility of Cell Counts in Nasal Lavage: A Comparison of Pooled Versus Non-Pooled Nasal Lavage Samples Completed NCT00229190
15 DUAL BRAVO PH MONITORING: A Feasibility Trial Completed NCT00378898
16 Treatment of Acne Vulgaris Using 1,565 nm Non-ablative Fractional Laser in Combination With Isotretinoin and Pricking Blood Therapy Completed NCT04156815 Oral isotretinoin

Search NIH Clinical Center for Vasomotor Rhinitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


azelastine
Azelastine hydrochloride
Brompheniramine
Brompheniramine Maleate
carbinoxamine
Carbinoxamine maleate
Ipratropium
Ipratropium Bromide
Phenylephrine
Phenylephrine bitartrate
Phenylephrine Hydrochloride
Phenylephrine Tannate
Phenylpropanolamine Hydrochloride
Scopolamine
Scopolamine Hydrobromide
tetrahydrozoline
Tetrahydrozoline hydrochloride

Cochrane evidence based reviews: rhinitis, vasomotor

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Genetic Tests for Vasomotor Rhinitis

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Anatomical Context for Vasomotor Rhinitis

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MalaCards organs/tissues related to Vasomotor Rhinitis:

40
Testes, Liver, Skin, Cortex, Heart, Thyroid, Tonsil
Sources

Publications for Vasomotor Rhinitis

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Articles related to Vasomotor Rhinitis:

(show top 50) (show all 655)
# Title Authors PMID Year
1
[The roles of three peptides in the pathogenesis of vasomotor rhinitis]. 54 61
17087112 2006
2
Eosinophil inflammation of the nasal mucosa in allergic and non-allergic rhinitis measured by eosinophil cationic protein levels in native nasal fluid and serum. 54 61
7889429 1994
3
Laser ablation of posterior nasal nerves for rhinitis. 61
31948695 2020
4
Ultrasound-guided acupuncture of the sphenopalatine ganglion for the treatment of vasomotor rhinitis: a case report. 61
32233776 2020
5
Newer Surgical Options for Nasal Allergy. 61
32158670 2020
6
Rhinorrhea as a Result of Alzheimer's Disease Treatment: A Case Report. 61
31818352 2019
7
Voice After Rhinoplasty. An Important Question for the Opera Singers. 61
31889647 2019
8
Asthma and allergies in pregnancy. 61
31690383 2019
9
Intranasal corticosteroids for non-allergic rhinitis. 61
31677153 2019
10
Allergic and nonallergic rhinitis. 61
31690374 2019
11
[Endoscopic posterior nasal neurectomy]. 61
31439065 2019
12
[Application of nasal saline irrigation in nasal inflammatory diseases]. 61
30669208 2019
13
[Therapeutic effect of nasal corticosteroids combined with nasal antihistamine on vasomotor rhinitis]. 61
30550209 2018
14
Cryotherapy for the Treatment of Chronic Rhinitis: A Qualitative Systematic Review. 61
30229670 2018
15
Surgical Management of Nonallergic Rhinitis. 61
29937065 2018
16
[Treatment of allergic and vasomotor rhinitis: the role of beclomethasone dipropionate and hyaluronic acid (with high molecular weight).] 61
29689043 2018
17
[Innovative technology full volume lavage of the nasal cavity in the treatment of allergic and vasomotor rhinitis]. 61
30412178 2018
18
[Cryosurgery in the treatment of allergic and non-allergic rhinitis]. 61
30267489 2018
19
[A variant of the modification of the rhinosurgical intervention with the use of the hemostatic glue]. 61
30412179 2018
20
[Research advances of pregnancy rhinitis]. 61
29798199 2017
21
Prognostic value of nasal cytology and clinical factors in nasal polyps development in patients at risk: can the beginning predict the end? 61
28665504 2017
22
[Clinical symptoms and immunology inspection characteristics of nasal cavity local allergy]. 61
29798346 2017
23
[Nasal irrigation for the treatment of vasomotor rhinitis: a pilot study]. 61
28635218 2017
24
[Nasal turbinate surgery]. 61
28401248 2017
25
Nasal Muco-ciliary transport time alteration: efficacy of 18 B Glycyrrhetinic acid. 61
29209499 2017
26
A Pilot Study Investigating Clinical Responses and Biological Pathways of Azelastine/Fluticasone in Nonallergic Vasomotor Rhinitis before and after Cold Dry Air Provocation. 61
28787742 2017
27
Combination therapy in allergic rhinitis: What works and what does not work. 61
28124648 2016
28
Severity of nasal obstruction can predict the anxiety status of patients with allergic rhinitis but not patients with vasomotor rhinitis. 61
27277070 2016
29
Is the location of a septal deviation associated with the degree of postoperative pain after septoplasty? 61
27792832 2016
30
Inferior Turbinate Hypertrophy in Rhinoplasty: Systematic Review of Surgical Techniques. 61
27556616 2016
31
Pathogenesis of rhinitis. 61
27434218 2016
32
NASAL cytology: practical aspects and clinical relevance. 61
27009397 2016
33
Nonallergic Rhinitis: Treatment. 61
27083104 2016
34
[Acute respiratory viral infections: Topical issues of diagnosis, prevention and treatment in therapeutic practice]. 61
28005035 2016
35
[About the unresolved problems of terminology and classification of allergic rhinitis and the desirability of distinguishing the mixed form of the disease]. 61
27876734 2016
36
Association between vasomotor rhinitis and irritable bowel syndrome. 61
28683253 2016
37
Vitamin D serum levels in children with allergic and vasomotor rhinitis. 61
26512257 2015
38
Endoscopic vidian neurectomy: a prospective case series. 61
25732231 2015
39
Surgical management of vasomotor rhinitis: a systematic review. 61
25785754 2015
40
[The disturbances of vegetative homeostasis in the children suffering from vasomotor rhinitis]. 61
26145742 2015
41
[The modern approach to the treatment of the patients presenting with vasomotor rhinitis with the use of the electrosurgical technique]. 61
26145748 2015
42
[The topical treatment of allergic and vasomotor rhinitis: the role of beclomethasone dipropionate]. 61
25424236 2014
43
"Overlapped" rhinitis: a real trap for rhinoallergologists. 61
25398169 2014
44
Rhinorrhea triggered by obturator prosthesis after surgical intervention of partial maxillary resection: a clinical report. 61
25503096 2014
45
[Diagnosis and clinical characteristics of patients with non-allergic rhinitis]. 61
25241870 2014
46
Long-term, randomized safety study of MP29-02 (a novel intranasal formulation of azelastine hydrochloride and fluticasone propionate in an advanced delivery system) in subjects with chronic rhinitis. 61
24607046 2014
47
Therapeutic effectiveness of endoscopic vidian neurectomy for the treatment of vasomotor rhinitis. 61
24433056 2014
48
[The clinical and functional evaluation of the combined treatment of vasomotor rhinitis in the children]. 61
25377674 2014
49
Intranasal capsaicin in management of nonallergic (vasomotor) rhinitis. 61
24941668 2014
50
High-content pSTAT3/1 imaging assays to screen for selective inhibitors of STAT3 pathway activation in head and neck cancer cell lines. 61
24127660 2014
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Variations for Vasomotor Rhinitis

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Expression for Vasomotor Rhinitis

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Search GEO for disease gene expression data for Vasomotor Rhinitis.
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Pathways for Vasomotor Rhinitis

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Pathways related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Peptide ligand-binding receptors 65
Show member pathways
 12.45 VIP TRPV1 TAC1 NPY NPS KNG1
2
G alpha (s) signalling events 65
11.3 VIP NPS CALCA
3
Endothelin Pathways 1
10.79 NPY CALCA
4
Inflammatory Response Pathway 1
10.67 IL5 CD40LG
Sources

GO Terms for Vasomotor Rhinitis

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Cellular components related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 TAC1 RNASE3 NPY KNG1 IL5 IL16
2 cell GO:0005623 9.55 TRPV1 TAC1 NPY KNG1 CALCA
3 extracellular region GO:0005576 9.32 VIP TAC1 RNASE3 NPY NPS KNG1

Biological processes related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.8 VIP TAC1 OR10A2 NPY NPS KNG1
2 positive regulation of cytosolic calcium ion concentration GO:0007204 9.62 TRPV1 TAC1 KNG1 CALCA
3 regulation of blood pressure GO:0008217 9.61 TAC1 NPY CALCA
4 leukocyte cell-cell adhesion GO:0007159 9.54 CD40LG CALCA
5 cellular response to nerve growth factor stimulus GO:1990090 9.54 TRPV1 TAC1 CALCA
6 positive regulation of blood vessel diameter GO:0097755 9.52 VIP CALCA
7 vasodilation GO:0042311 9.51 KNG1 CALCA
8 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.49 TRPV1 CALCA
9 positive regulation of synaptic transmission, GABAergic GO:0032230 9.48 TAC1 NPS
10 negative regulation of heart rate GO:0010459 9.46 TRPV1 TAC1
11 neuropeptide signaling pathway GO:0007218 9.46 TAC1 NPY NPS CALCA
12 positive regulation of action potential GO:0045760 9.4 TAC1 NPS
13 response to pain GO:0048265 9.13 TRPV1 TAC1 CALCA
14 inflammatory response GO:0006954 9.1 TRPV1 TAC1 KNG1 IL5 CD40LG CALCA

Molecular functions related to Vasomotor Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 8.96 VIP NPY
2 hormone activity GO:0005179 8.8 VIP NPY CALCA
Sources

Sources for Vasomotor Rhinitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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