Aliases & Classifications for Vein Disease

Summaries for Vein Disease

Disease Ontology : 12 A vascular disease that is located in a vein.

MalaCards based summary : Vein Disease, also known as disorder of vein, is related to varicose veins and venous insufficiency, and has symptoms including vein pain An important gene associated with Vein Disease is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Regulation of lipid metabolism Insulin signaling-generic cascades. The drugs Rivaroxaban and Sodium Tetradecyl Sulfate have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and placenta, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Vein Disease

Diseases related to Vein Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 191)
# Related Disease Score Top Affiliating Genes
1 varicose veins 31.9 F2 F5 MTHFR SERPINC1 VEGFA
2 venous insufficiency 31.8 F2 PLAT SERPINE1
3 thrombophlebitis 29.2 F2 F5 MTHFR PLAT SERPINC1 SERPINE1
4 pulmonary embolism 28.6 ALB F2 F3 F5 MTHFR PLAT
5 thrombosis 28.2 F2 F3 F5 MTHFR PLAT PROC
6 hemoglobin e disease 10.6 F2 F5
7 abdominal tuberculosis 10.5 ALB F2
8 endometrial small cell carcinoma 10.5 AFP F2
9 severe nonproliferative diabetic retinopathy 10.5 ALB VEGFA
10 vitreous detachment 10.5 PLG VEGFA
11 qualitative platelet defect 10.5 F2 F3
12 antipyrine metabolism 10.4 ALB F2
13 non-a-e hepatitis 10.4 ALB F2
14 paracetamol poisoning 10.4 F2 F5
15 heparin-induced thrombocytopenia 10.4 F3 SERPINC1
16 prothrombin deficiency 10.4 F2 F3
17 arteritic anterior ischemic optic neuropathy 10.4 F2 F5 MTHFR
18 aspirin allergy 10.4 SERPINC1 SERPINE1
19 sudden sensorineural hearing loss 10.4 F2 F5 MTHFR
20 porencephaly 10.4 F2 F5 MTHFR
21 tuberculous empyema 10.4 PLG SERPINE1
22 epstein-barr virus hepatitis 10.4 ALB F2
23 prothrombin deficiency, congenital 10.4 F2 F5 SERPINC1
24 platelet aggregation, spontaneous 10.3 PLAT SERPINC1
25 alpha-2-plasmin inhibitor deficiency 10.3 F2 PLG SERPINC1
26 hypersplenism 10.3 ALB F2 SERPINC1
27 central retinal artery occlusion 10.3 PLAT PLG
28 inferior myocardial infarction 10.3 PLAT PLG
29 anterior spinal artery syndrome 10.3 F2 PLG SERPINC1
30 hemifacial spasm 10.3 MTHFR VEGFA
31 afibrinogenemia 10.3 F2 F3 F5
32 spinal cord infarction 10.3 F2 F5 MTHFR SERPINC1
33 inferior vena cava interruption 10.3 F5 MTHFR SERPINE1
34 conjugate gaze palsy 10.3 F3 PLG
35 antithrombin iii deficiency 10.3 F2 F5 MTHFR SERPINC1
36 amaurosis fugax 10.3 F5 MTHFR SERPINE1
37 placental abruption 10.3 F2 F5 MTHFR SERPINC1
38 ischemic optic neuropathy 10.3 F2 F5 MTHFR SERPINC1
39 nonarteritic anterior ischemic optic neuropathy 10.3 F2 F5 MTHFR SERPINC1
40 peliosis hepatis 10.3 AFP F2 VEGFA
41 eclampsia 10.3 ALB F2 MTHFR SERPINC1
42 cerebral palsy 10.3 F2 F5 MTHFR
43 neonatal stroke 10.3 MTHFR PROC SERPINE1
44 buerger disease 10.3 F2 MTHFR SERPINE1
45 cerebral falx meningioma 10.3 F2 F3 PLG
46 ovarian hyperstimulation syndrome 10.3 ALB F5 VEGFA
47 hepatoportal sclerosis 10.3 F2 GPT
48 inherited blood coagulation disease 10.2 F2 F3 SERPINC1
49 central serous chorioretinopathy 10.2 PLAT SERPINE1
50 femoral neuropathy 10.2 F2 F3 PLG

Graphical network of the top 20 diseases related to Vein Disease:



Diseases related to Vein Disease

Symptoms & Phenotypes for Vein Disease

UMLS symptoms related to Vein Disease:


vein pain

MGI Mouse Phenotypes related to Vein Disease:

47 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.47 ADAM17 AFP ALB BLOC1S2 EPAS1 F2
2 cardiovascular system MP:0005385 10.4 ADAM17 BLOC1S2 EPAS1 F2 F3 F5
3 mortality/aging MP:0010768 10.38 ADAM17 AFP ALB BLOC1S2 EPAS1 F2
4 growth/size/body region MP:0005378 10.37 ADAM17 EPAS1 F2 F3 F5 MTHFR
5 hematopoietic system MP:0005397 10.29 ADAM17 BLOC1S2 EPAS1 F2 F3 PLAT
6 embryo MP:0005380 10.24 ADAM17 BLOC1S2 EPAS1 F2 F3 F5
7 immune system MP:0005387 10.22 ADAM17 EPAS1 F2 F3 PLAT PLG
8 liver/biliary system MP:0005370 10.21 AFP ALB BLOC1S2 EPAS1 F5 MTHFR
9 integument MP:0010771 10.16 ADAM17 F2 F3 F5 MTHFR PLAT
10 nervous system MP:0003631 10.13 ADAM17 BLOC1S2 EPAS1 F2 F3 F5
11 digestive/alimentary MP:0005381 10.09 ADAM17 ALB F2 PLAT PLG SST
12 muscle MP:0005369 10.02 ADAM17 ALB EPAS1 F3 PARVA PLAT
13 neoplasm MP:0002006 9.8 AFP ALB F3 PLG SERPINE1 VEGFA
14 normal MP:0002873 9.76 ADAM17 ALB F2 F3 PROS1 RAB3D
15 respiratory system MP:0005388 9.65 ADAM17 EPAS1 F2 F3 PLAT PLG
16 vision/eye MP:0005391 9.28 ADAM17 BLOC1S2 EPAS1 F3 MTHFR PLAT

Drugs & Therapeutics for Vein Disease

Drugs for Vein Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 102)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rivaroxaban Approved Phase 4,Phase 3 366789-02-8
2
Sodium Tetradecyl Sulfate Approved, Investigational Phase 4,Not Applicable 139-88-8, 1191-50-0 5248 14492
3
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
4
Racepinephrine Approved Phase 4 329-65-7 838
5
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
6
Polidocanol Approved Phase 4 9002-92-0
7
Serine Approved, Nutraceutical Phase 4,Phase 3 56-45-1 5951
8 Hemostatics Phase 4,Phase 3
9 Aminaftone Phase 4
10 Coagulants Phase 4,Phase 3
11 Pharmaceutical Solutions Phase 4,Not Applicable
12
protease inhibitors Phase 4,Phase 3
13 Antithrombins Phase 4,Phase 3
14 Factor Xa Inhibitors Phase 4,Phase 3
15 HIV Protease Inhibitors Phase 4,Phase 3
16 Anticoagulants Phase 4,Phase 3,Phase 2
17 Antithrombin III Phase 4,Phase 3
18 Serine Proteinase Inhibitors Phase 4,Phase 3
19 Anti-Inflammatory Agents Phase 4,Not Applicable
20 Calamus Phase 4,Not Applicable
21 Adrenergic alpha-Agonists Phase 4
22 Epinephryl borate Phase 4
23 Bronchodilator Agents Phase 4
24 Adrenergic Agents Phase 4
25 Adrenergic Agonists Phase 4
26 Central Nervous System Depressants Phase 4
27 Diuretics, Potassium Sparing Phase 4
28 Neurotransmitter Agents Phase 4
29 Anti-Arrhythmia Agents Phase 4
30 Respiratory System Agents Phase 4
31 Vasoconstrictor Agents Phase 4
32 Sclerosing Solutions Phase 4,Not Applicable
33 Mydriatics Phase 4
34 Anesthetics, Local Phase 4
35 Sodium Channel Blockers Phase 4
36 Sympathomimetics Phase 4
37 Peripheral Nervous System Agents Phase 4
38 Autonomic Agents Phase 4
39 Anti-Asthmatic Agents Phase 4
40 Adrenergic beta-Agonists Phase 4
41 Anesthetics Phase 4
42
Sodium Citrate Approved, Investigational Phase 3 68-04-2
43
carbamide peroxide Approved Phase 2, Phase 3 124-43-6
44
Warfarin Approved Phase 3 81-81-2 54678486 6691
45
Heparin Approved, Investigational Phase 3,Not Applicable 9005-49-6 46507594 772
46
Tinzaparin Approved Phase 3 9041-08-1, 9005-49-6 25244225
47
Enoxaparin Approved Phase 3 9005-49-6 772
48
Dalteparin Approved Phase 3 9005-49-6
49
Nadroparin Approved, Investigational Phase 3
50
Becaplermin Approved, Investigational Phase 3 165101-51-9

Interventional clinical trials:

(show top 50) (show all 88)
# Name Status NCT ID Phase Drugs
1 Compression Aided Management of Edema in Patients With C3 Venous Disease Unknown status NCT00766974 Phase 4
2 Efficacy on Pain Following a Procedure for Injecting Sclerotherapeutic Foam Into the Great Saphenous Vein Completed NCT01368159 Phase 4
3 ClosureFAST vs. Laser Ablation for the Treatment of GSV Disease: A Multicenter, Single-Blinded, Randomized Study. Completed NCT00509392 Phase 4
4 Iliac Vein Stenting in Advanced Chronic Venous Insufficiency Completed NCT02149212 Phase 4 Phlebotonic
5 Laser Ablation Versus Mechanochemical Ablation Trial Recruiting NCT02627846 Phase 4 Lidocaine with 1:200,000 epinephrine solution;Lidocaine with 1:200,000 epinephrine solution;Sodium Bicarbonate;Sodium Tetradecyl Sulphate
6 Rivaroxaban With Diosmine in Long-term Treatment of DVT Active, not recruiting NCT03413618 Phase 4 Rivaroxaban;Diosmin
7 Study of Antiinflammatory Effects of Detralex (Daflon) Enrolling by invitation NCT01654016 Phase 4 Detralex
8 Effect of PEM Treatment of Superficial Axial and Tributary Vein Reflux on Improvement of Wound Healing in VLUs Withdrawn NCT02988063 Phase 4 Polidocanol Endovenous Microfoam (PEM)
9 RCT Comparing Standard Cannula Delivered FS, UGFS and ClariVein® in the Management of SVI Withdrawn NCT02010437 Phase 4 Sodium Tetradecyl Sulphate (STS)
10 PRP ULCERAS: Clinical Trial Phase III Unknown status NCT02213952 Phase 3 Platelet-Rich Plasma
11 Efficacy and Safety of Diosmin 600mg Versus Placebo on Painful Symptomatology in Patients With Chronic Venous Disease of Lower Limbs Completed NCT01532882 Phase 3 Diosmin;Placebo
12 The Influence of Compression Stockings on Skin's Barrier Function at Patients With Chronic Venous Disease Completed NCT00196443 Phase 2, Phase 3
13 Efficacy on Volume Reduction and Tolerance of Progressiv' Medical Compressive Therapy (MCT) V0322 BC in Patients With Chronic Venous Oedema Completed NCT01402921 Phase 3
14 Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis Completed NCT00790335 Phase 3 Recombinant tissue plasminogen activator (rt-PA)
15 The SOX Trial: Compression Stockings to Prevent the Post-Thrombotic Syndrome Completed NCT00143598 Phase 3
16 Randomized Controlled Trial of Anticoagulation vs. Placebo for a First Symptomatic Isolated Distal Deep-vein Thrombosis (IDDVT) Completed NCT00421538 Phase 3 nadroparine calcium;Placebo
17 Rivaroxaban Anticoagulation for Superficial Vein Thrombosis Completed NCT02123524 Phase 3 Rivaroxaban;Placebo
18 Crenobalneotherapy in the Treatment of Chronic Venous Insufficiency Completed NCT01956318 Phase 3
19 Study of Combined Topical Growth Factor and Protease Inhibitor in Chronic Wound Healing Not yet recruiting NCT02845466 Phase 3
20 The MUFFIN-PTS Trial Not yet recruiting NCT03833024 Phase 3 Micronized Purified Flavonoid Fraction;Placebo
21 Calcium Dobesilate for Chronic Venous Wounds Suspended NCT00979836 Phase 3 Calcium Dobesilate
22 Great Saphenous Vein Electrocoagulation Unknown status NCT02139085 Phase 2
23 Non-Healing Ulcers Without Critical Limb Ischemia Unknown status NCT01666093 Phase 2
24 Treatment of Claudication With a Peristaltic Pulse Pneumatic Device Unknown status NCT01007604 Phase 2
25 Surface NeuroMuscular Electrical Stimulation in the Treatment of Chronic Venous Leg Ulcers Completed NCT01801891 Phase 2
26 Cooling Lower Leg Skin to Prevent Venous Leg Ulcers in Patients With Poor Vein Circulation Completed NCT01509599 Phase 1, Phase 2
27 Physical Conditioning in Management of Chronic Venous Insufficiency Completed NCT00013273 Phase 2
28 Mesoglycan (Prisma®) Versus Placebo in Secondary Prevention of the Superficial Venous Thrombosis Recruiting NCT03428711 Phase 2 Mesoglycan Oral Tablet;Placebo Oral Tablet
29 EXPLORATORY ASSESSMENT OF THE EFFECTS OF CYCLO 3 ® FORT (Ruscus Extract, Hesperidin Methyl Chalcone, Ascorbic Acid) OR MICRONISED PURIFIED FLAVONOID FRACTION ON VASCULAR PARAMETERS AND BIOMARKERS IN WOMEN SUFFERING FROM CHRONIC VENOUS DISEASE (CEAP C2 OR C3), OVER 8 WEEKS Withdrawn NCT02907320 Phase 2 CYCLO 3 ® FORT;MPFF;placebo CYCLO 3 ® FORT;placebo MPFF
30 Tissue Engineered Veins in Patients With Chronic Venous Insufficiency Not yet recruiting NCT03784131 Phase 1 P-TEV
31 Elastic Compression in Chronic Venous Disease Unknown status NCT02641600 Not Applicable
32 Effect of Standing, Lying and Stockings on Blood Bio-markers (v.1) Unknown status NCT02662127 Not Applicable
33 Venous Pressure Measurement of the Great Saphenous Vein Using Controlled Compression Ultrasound in Healthy Persons and Patients With Chronic Venous Disease as a New Non Invasive Method for Investigation of the Pathophysiology in Primary Varicose Veins Unknown status NCT01000909
34 Prevalence of Chronic Venous Disease in General Population Completed NCT03900234
35 Prevalence of Onychodystrophy in Patients With Chronic Venous Disease of the Lower Limbs Completed NCT02731222
36 Evaluating the Occurence of New and Progression of Existing Peripheral Venous Disease in Leg Veins Completed NCT00508079
37 Prevalence of MTHFR Polymorphisms in Venous Disease Completed NCT01993914
38 Estrogen Receptors and Chronic Venous Disease Completed NCT02558426
39 FOAM-study, Cost Minimization Study Comparing Surgery Versus Duplex Guided Foam Sclerotherapy of Varicose Veins Completed NCT01103258 Not Applicable
40 Epidemiology of Venous Disease Completed NCT00005392
41 Venous Insufficiency and Neuromuscular Stimulation Completed NCT02137499 Not Applicable
42 Pen Torch Transillumination: Shedding Light on Difficult Venepuncture Completed NCT02570568 Not Applicable
43 Treatment of Insufficient Superficial and Perforating Veins of the Lower Limb Using HIFU Completed NCT03304834 Not Applicable
44 Copper Impact on Venous Insufficiency and Lipodermatosclerosis Completed NCT03283800 Not Applicable
45 LLLT of Trophic Ulcers of Lower Extremities and Chronic Venous Insufficiency Completed NCT03104985 Not Applicable
46 Manual Lymphatic Drainage in Chronic Venous Insufficiency: a Randomized Controlled Trial Completed NCT01899482 Not Applicable
47 Evaluating the Relationship Between Blood Clotting Disorders, Inflammation, and Obesity in Individuals With Venous Disorders and Post-Thrombotic Syndrome Completed NCT00395265
48 Compression Therapy Versus Surgery in the Treatment of Superficial Venous Reflux Completed NCT01701661 Not Applicable
49 Non-Invasive Management of Chronic Venous Insufficiency Completed NCT00950378
50 Effect of Intensive Sports Practice on Lower Limb Varicose Veins Completed NCT02846051 Not Applicable

Search NIH Clinical Center for Vein Disease

Genetic Tests for Vein Disease

Anatomical Context for Vein Disease

MalaCards organs/tissues related to Vein Disease:

42
Skin, Spinal Cord, Placenta

The Foundational Model of Anatomy Ontology organs/tissues related to Vein Disease:

20
A Vein

Publications for Vein Disease

Articles related to Vein Disease:

(show all 49)
# Title Authors Year
1
Early clinical experience using telemedicine for the management of patients with varicose vein disease. ( 28969485 )
2019
2
Small RNA-Seq to Characterize Viruses Responsible of Lettuce Big Vein Disease in Spain. ( 30622528 )
2018
3
DNA methylation and gene expression profiling reveal MFAP5 as a regulatory driver of extracellular matrix remodeling in varicose vein disease. ( 30070582 )
2018
4
Present and future options for treatment of infrainguinal deep vein disease. ( 30007531 )
2018
5
Commentary on the article "A prospective study of a vein sparing technique for the management of varicose vein disease" by M Zmudzinski et al. ( 29122236 )
2018
6
CHIVA - A prospective study of a vein sparing technique for the management of varicose vein disease. ( 28431588 )
2017
7
Guidelines of the First International Consensus Conference on Endovenous Thermal Ablation for Varicose Vein Disease--ETAV Consensus Meeting 2012. ( 24534341 )
2015
8
First Report of a Novel Begomovirus Associated with Yellow Vein Disease of Browne's Blechum (Blechum pyramidatum). ( 30708545 )
2014
9
Cost analysis of endovenous catheter ablation versus surgical stripping for treatment of superficial venous insufficiency and varicose vein disease. ( 26992979 )
2014
10
Evaluation of apoptosis in varicose vein disease complicated by superficial vein thrombosis. ( 25007903 )
2014
11
Platelet distribution width and saphenous vein disease in patients after CABG. Association with graft occlusion. ( 22955688 )
2013
12
Relationships Between the Pathogen Olpidium virulentus and Viruses Associated with Lettuce Big-Vein Disease. ( 30722639 )
2013
13
Molecular characterization and population structure of blackberry vein banding associated virus, new Ampelovirus associated with yellow vein disease. ( 24126200 )
2013
14
A review of familial, genetic, and congenital aspects of primary varicose vein disease. ( 22896013 )
2012
15
The hemodynamic paradox as a phenomenon triggering recurrent reflux in varicose vein disease. ( 23997567 )
2012
16
The significance of upper arm cephalic vein disease in vascular access creation. ( 23020965 )
2012
17
Increased vein wall apoptosis in varicose vein disease is related to venous hypertension. ( 21262580 )
2011
18
Molecular and biological characterization of pepper yellow vein Mali virus (PepYVMV) isolates associated with pepper yellow vein disease in Burkina Faso. ( 21080204 )
2011
19
Superficial thrombophlebitis in varicose vein disease: the particular role of methylenetetrahydrofolate reductase. ( 21690171 )
2011
20
Superficial thrombophlebitis in varicose vein disease: the particular role of methylenetetrahydrofolate reductase. ( 20881312 )
2011
21
Chronic venous insufficiency: current management of varicose vein disease. ( 20336886 )
2010
22
Pathogenic mechanisms in varicose vein disease: the role of hypoxia and inflammation. ( 20632821 )
2010
23
Minimally invasive vein surgery: latest options for vein disease. ( 20506452 )
2010
24
Endovenous laser ablation for the treatment of recurrent varicose vein disease--a single centre experience. ( 20227536 )
2010
25
Identification of Lettuce big-vein associated virus and Mirafiori lettuce big-vein virus Associated with Lettuce Big-Vein Disease in Slovenia. ( 30764170 )
2009
26
Further evidence of Mirafiori lettuce big-vein virus but not of Lettuce big-vein associated virus with big-vein disease in lettuce. ( 18944196 )
2008
27
The economics of vein disease. ( 17911565 )
2007
28
Commentary on "The economics of vein disease". ( 17911566 )
2007
29
Surgical correction of varicose vein disease under micronized diosmin protection (results of the Russian multicenter controlled trial DEFANS). ( 18004259 )
2007
30
Changes in the wall of the great saphenous vein at consecutive stages in patients suffering from chronic vein disease of the lower limbs. ( 17985316 )
2007
31
A begomovirus associated with Ageratum yellow vein disease in Indonesia: evidence for natural recombination between tomato leaf curl Java virus and Ageratum yellow vein virus-[Java]. ( 17294343 )
2007
32
The histopathology of varicose vein disease. ( 17067976 )
2006
33
Selection of saphenous vein conduit in varicose vein disease. ( 16564256 )
2006
34
The DNA beta satellite component associated with ageratum yellow vein disease encodes an essential pathogenicity protein (betaC1). ( 15183051 )
2004
35
Nucleotide sequence and genomic organization of an ophiovirus associated with lettuce big-vein disease. ( 12388823 )
2002
36
Adaptation from whitefly to leafhopper transmission of an autonomously replicating nanovirus-like DNA component associated with ageratum yellow vein disease. ( 11907341 )
2002
37
Pathogenicity of a natural recombinant associated with ageratum yellow vein disease: implications for geminivirus evolution and disease aetiology. ( 11259188 )
2001
38
A unique virus complex causes Ageratum yellow vein disease. ( 10841581 )
2000
39
Association of a Begomovirus and Nanovirus-like Molecule with Ageratum Yellow Vein Disease in Pakistan. ( 30841203 )
2000
40
A nanovirus-like DNA component associated with yellow vein disease of Ageratum conyzoides: evidence for interfamilial recombination between plant DNA viruses. ( 10544139 )
1999
41
Symptomatology of vein disease. ( 7728483 )
1995
42
Unsuspected preexisting saphenous vein disease: an unrecognized cause of vein bypass failure. ( 1728668 )
1992
43
The management of varicose vein disease. ( 287952 )
1979
44
The modern treatment of varicose vein disease. ( 4520459 )
1973
45
Phlebography in varicose vein disease. ( 5014478 )
1972
46
Mesenteric vein disease. ( 13740328 )
1961
47
Yellow-vein disease of citrus and studies of interactions between yellow-vein and other viruses of citrus. ( 13843232 )
1960
48
Pulmonary embolism; its incidence, significance, and relation to antecedent vein disease. ( 18111784 )
1949
49
Pulmonary embolism; its incidence, significance, and relation to antecedent vein disease. ( 18877800 )
1948

Variations for Vein Disease

Expression for Vein Disease

Search GEO for disease gene expression data for Vein Disease.

Pathways for Vein Disease

Pathways related to Vein Disease according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.97 ALB F2 F3 F5 PLAT PLG
2
Show member pathways
12.72 ADAM17 PLAT PLG SERPINE1 VEGFA
3
Show member pathways
12.63 F2 F3 F5 PROC PROS1 SERPINC1
4
Show member pathways
12.07 ALB F2 MTHFR PLAT PLG SERPINE1
5 11.85 F3 PARVA PLG SERPINE1
6
Show member pathways
11.81 F2 F3 F5 PLAT PLG PROC
7
Show member pathways
11.77 F2 PROC PROS1
8 11.71 F3 SERPINE1 VEGFA
9 11.49 PLAT PLG SERPINE1
10 11.42 F2 F3 F5 PLAT PLG PROC
11 11.38 PLAT PLG VEGFA
12 11.31 AFP ALB F2
13 11.18 EPAS1 SERPINE1 VEGFA
14 10.94 ADAM17 PLAT PLG
15 10.8 EPAS1 VEGFA
16 10.72 F2 PROC PROS1
17 10.61 PLAT PLG SERPINE1

GO Terms for Vein Disease

Cellular components related to Vein Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.97 AFP ALB F2 F3 F5 PLAT
2 collagen-containing extracellular matrix GO:0062023 9.77 F3 PLAT PLG SERPINC1 SERPINE1
3 endoplasmic reticulum lumen GO:0005788 9.73 AFP ALB F2 F5 PROC SERPINC1
4 blood microparticle GO:0072562 9.72 ALB F2 PLG PROS1 SERPINC1
5 Golgi lumen GO:0005796 9.61 F2 PROC PROS1
6 extracellular space GO:0005615 9.47 AFP ALB F2 F3 F5 GPT
7 platelet alpha granule lumen GO:0031093 9.43 ALB F5 PLG PROS1 SERPINE1 VEGFA
8 extracellular exosome GO:0070062 10.06 ALB F2 GPT PLAT PLG PROS1

Biological processes related to Vein Disease according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.88 AFP ALB EPAS1 F5 PROC SERPINC1
2 response to hypoxia GO:0001666 9.83 ADAM17 EPAS1 MTHFR PLAT VEGFA
3 platelet degranulation GO:0002576 9.8 ALB F5 PLG PROS1 SERPINE1 VEGFA
4 cellular protein metabolic process GO:0044267 9.8 AFP ALB F2 F5 PLG PROC
5 ER to Golgi vesicle-mediated transport GO:0006888 9.78 F2 F5 PROC PROS1
6 negative regulation of blood coagulation GO:0030195 9.63 PROC PROS1 SERPINE1
7 blood coagulation GO:0007596 9.56 F2 F3 F5 PLAT PLG PROC
8 positive regulation of blood coagulation GO:0030194 9.55 F2 SERPINE1
9 fibrinolysis GO:0042730 9.55 F2 PLAT PLG PROS1 SERPINE1
10 regulation of blood coagulation GO:0030193 9.54 F2 SERPINC1
11 negative regulation of fibrinolysis GO:0051918 9.54 F2 PLG SERPINE1
12 positive regulation of positive chemotaxis GO:0050927 9.52 F3 VEGFA
13 surfactant homeostasis GO:0043129 9.51 EPAS1 VEGFA
14 positive regulation of cellular component movement GO:0051272 9.49 ADAM17 VEGFA
15 hemostasis GO:0007599 9.17 F2 F3 F5 PLG PROC PROS1

Molecular functions related to Vein Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.55 ADAM17 F2 PLAT PLG PROC
2 protease binding GO:0002020 9.43 F3 SERPINC1 SERPINE1
3 serine-type peptidase activity GO:0008236 9.26 F2 PLAT PLG PROC
4 serine-type endopeptidase activity GO:0004252 9.02 F2 F3 PLAT PLG PROC

Sources for Vein Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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