MCID: VND001
MIFTS: 42

Vein Disease

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Vein Disease

MalaCards integrated aliases for Vein Disease:

Name: Vein Disease 12 15
Disorder of Vein 70

Classifications:



External Ids:

Disease Ontology 12 DOID:866
ICD9CM 34 453
SNOMED-CT 67 195435006
UMLS 70 C0155774 C0235522

Summaries for Vein Disease

Disease Ontology : 12 A vascular disease that is located in a vein.

MalaCards based summary : Vein Disease, also known as disorder of vein, is related to venous insufficiency and varicose veins, and has symptoms including vein pain An important gene associated with Vein Disease is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Ethanol and Heparin have been mentioned in the context of this disorder. Affiliated tissues include a vein, skin and myeloid, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Vein Disease

Diseases in the Vein Disease family:

Congenital Systemic Veins Anomaly

Diseases related to Vein Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 693)
# Related Disease Score Top Affiliating Genes
1 venous insufficiency 32.0 VEGFA MTHFR F5 F2 CRP
2 varicose veins 31.8 VEGFA SERPINC1 MTHFR MIR202 IL6 F5
3 chronic venous insufficiency 30.5 VEGFA MTHFR F2 CRP
4 pulmonary embolism 30.1 SERPINC1 PROS1 PROC MTHFR F5 F3
5 varicocele 30.1 MTHFR IL6 ALB
6 thrombophlebitis 29.9 SERPINC1 PROS1 PROC PLG MTHFR F5
7 protein s deficiency 29.9 SERPINC1 PROS1 PROC MTHFR F5 F3
8 thrombosis 29.8 SERPINC1 PROS1 PROC PLG MTHFR F5
9 venous malformations, multiple cutaneous and mucosal 10.9
10 non-a-e hepatitis 10.6 F2 ALB
11 antipyrine metabolism 10.6 F2 ALB
12 paracetamol poisoning 10.6 F5 F2
13 arteritic anterior ischemic optic neuropathy 10.6 MTHFR F5 F2
14 orbital osteomyelitis 10.5 F2 CRP
15 amaurosis fugax 10.5 MTHFR F5
16 hepatoportal sclerosis 10.5 GPT F2
17 small intestine diverticulitis 10.5 F2 CRP
18 dipetalonemiasis 10.5 GPT ALB
19 neonatal stroke 10.5 PROC MTHFR
20 cholecystitis 10.5 GPT F2 ALB
21 hemifacial spasm 10.5 VEGFA MTHFR
22 aspirin resistance 10.5 F5 F2
23 chronic duodenal ileus 10.5 CRP ALB
24 glossopharyngeal nerve paralysis 10.5 CRP AFP
25 lateral sinus thrombosis 10.5 SERPINC1 MTHFR F2
26 pylorus cancer 10.5 SST ALB
27 cryptogenic cirrhosis 10.5 MTHFR F5 F2
28 heterophyiasis 10.5 GPT ALB
29 thymus sarcomatoid carcinoma 10.5 ALB AFP
30 femoral neuropathy 10.5 F3 F2
31 beta-thalassemia major 10.5 MTHFR F5 F2
32 prothrombin deficiency, congenital 10.5 SERPINC1 F5 F2
33 acquired hemophilia 10.5 F5 F3
34 acquired hemophilia a 10.5 F5 F3
35 sticky platelet syndrome 10.5 SERPINC1 F5
36 meningococcemia 10.5 SERPINC1 PROC F5
37 acquired angioedema 10.5 F5 CRP
38 papillary adenofibroma 10.5 F3 F2 AFP
39 pyridoxine deficiency anemia 10.5 GPT F2
40 hypertensive encephalopathy 10.5 VEGFA F2 ALB
41 heparin-induced thrombocytopenia 10.5 SERPINC1 F3
42 vagus nerve disease 10.5 ATP4A ATP12A
43 medulloadrenal hyperfunction 10.5 PLG F3
44 thrombotic microangiopathy 10.5 VEGFA F3
45 dic in newborn 10.5 SERPINC1 F3 F2
46 hematocele of tunica vaginalis testis 10.5 F2 CRP AFP
47 waterhouse-friderichsen syndrome 10.5 SERPINC1 F3 F2
48 peliosis hepatis 10.5 GPT F2 AFP
49 sneddon syndrome 10.5 SERPINC1 F5 F2
50 anterior spinal artery syndrome 10.5 PLG F2

Graphical network of the top 20 diseases related to Vein Disease:



Diseases related to Vein Disease

Symptoms & Phenotypes for Vein Disease

UMLS symptoms related to Vein Disease:


vein pain

MGI Mouse Phenotypes related to Vein Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.39 AFP ALB ATP12A ATP4A CCR6 CRP
2 cardiovascular system MP:0005385 10.22 ALB CRP F2 F3 F5 IL6
3 immune system MP:0005387 10.18 ALB ATP4A CCR6 CRP F2 F3
4 mortality/aging MP:0010768 10.1 AFP ALB ATP4A F2 F3 F5
5 digestive/alimentary MP:0005381 10.06 ALB ATP12A ATP4A F2 IL6 PLG
6 integument MP:0010771 10.02 F2 F3 F5 IL6 MTHFR PLG
7 liver/biliary system MP:0005370 10.02 AFP ALB F5 IL6 MTHFR PLG
8 muscle MP:0005369 9.76 ALB F2 F3 IL6 PROC PROS1
9 neoplasm MP:0002006 9.5 AFP ALB ATP4A F3 IL6 PLG
10 nervous system MP:0003631 9.4 CCR6 F2 F3 F5 IL6 MTHFR

Drugs & Therapeutics for Vein Disease

Drugs for Vein Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved 64-17-5 702
2
Heparin Approved, Investigational 9005-49-6 772 9812414
3 calcium heparin
4 Calamus

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pen Torch Transillumination: Shedding Light on Difficult Venepuncture Completed NCT02570568
2 FOAM-study Cost Minimization Study Comparing Surgery Versus Duplex Guided Foam Sclerotherapy of Varicose Veins: a Randomized Controlled Study Completed NCT01103258

Search NIH Clinical Center for Vein Disease

Genetic Tests for Vein Disease

Anatomical Context for Vein Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Vein Disease:

19
A Vein

MalaCards organs/tissues related to Vein Disease:

40
Skin, Myeloid, Neutrophil

Publications for Vein Disease

Articles related to Vein Disease:

(show top 50) (show all 213)
# Title Authors PMID Year
1
[Anatomy of foot perforator veins in surgery of varicose veins]. 61
33395515 2021
2
Capillary-venule malformation is a microfistulous variant of arteriovenous malformation. 61
32470616 2021
3
Cardiac catheterization for hemoptysis in a Children's Hospital Cardiac Catheterization Laboratory: A 15 year experience. 61
32951945 2021
4
Impact of lipid levels and high-intensity statins on vein graft patency after CABG: Midterm results of the ACTIVE trial. 61
33025656 2020
5
A temperature-dependent phenology model for the greenhouse whitefly Trialeurodes vaporariorum (Hemiptera: Aleyrodidae). 61
32800806 2020
6
The biomechanical impact of hip movement on iliofemoral venous anatomy and stenting for deep venous thrombosis. 61
32321693 2020
7
Saphenous vein disease: Influence of preimplantation wall changes on graft patency. 61
32725649 2020
8
Left temporal hemorrhage caused by cerebral venous reflux of a brachio-brachial hemodialysis fistula. 61
32448996 2020
9
Novel Approach to Treatment of Chronic Iliocaval Occlusion Utilizing Covered Stents. 61
32173477 2020
10
Iliocaval outflow obstruction in patients with venous ulcers in a small comparison study between patients with primary varicose veins and chronic deep vein disease. 61
32827736 2020
11
Lower Extremity Venous Stent Placement: A Large Retrospective Single-Center Analysis. 61
31542273 2020
12
Votive Reliefs of Lower Extremities Disorders: A Brief Review. 61
32211256 2020
13
[Complete myocardial revascularization in patients with multiple-vessel coronary artery disease and partial or complete absence of the grafts for coronary artery bypass surgery]. 61
33030011 2020
14
PATHOPHYSIOLOGICAL AND ATHOMORPHOLOGICAL ASPECTS OF RELAPSE OF VARICOSE VEINS AFTER ENDOVASCULAR LASER VEIN COAGULATION. 61
33454685 2020
15
FEATURES OF CLINICAL SYMPTOMS AND SIGNS, HEMATOLOGICAL AND BIOCHEMICAL PARAMETERS IN CHILDREN WITH JOINT HYPERMOBILITY IN A LATE PERIOD UPON THE CHORNOBYL NPP ACCIDENT. 61
31841477 2019
16
Single- versus multiple-stage catheter-directed thrombolysis for acute iliofemoral deep venous thrombosis does not have an impact on iliac vein stent length or patency rates. 61
31495769 2019
17
Foam Sclerotherapy: An Emerging, Minimally Invasive And Safe Modality Of Treatment For Varicose Veins. 61
31965766 2019
18
[Thromboembolic vein disease (TVD): antithrombotic therapy choice in ASL TO3.] 61
31593179 2019
19
Surgical and endovascular central venous reconstruction combined with thoracic outlet decompression in highly symptomatic patients. 61
30442583 2019
20
[Venous wall weackness pathogenesis in varicose vein disease]. 61
31626242 2019
21
Early clinical experience using telemedicine for the management of patients with varicose vein disease. 61
28969485 2019
22
Clinical and Genetic Determinants of Varicose Veins. 61
30566020 2018
23
Commentary on the article "A prospective study of a vein sparing technique for the management of varicose vein disease" by M Zmudzinski et al. 61
29122236 2018
24
Molecular characterization and detection of a novel vitivirus infecting blackberry. 61
29987381 2018
25
Present and future options for treatment of infrainguinal deep vein disease. 61
30007531 2018
26
Cumulative Effect of Preoperative Risk Factors on Mortality After Pediatric Heart Transplantation. 61
29684375 2018
27
The effectiveness of various interventions versus standard stripping in patients with varicose veins in terms of quality of life. 61
28720052 2018
28
DNA methylation and gene expression profiling reveal MFAP5 as a regulatory driver of extracellular matrix remodeling in varicose vein disease. 61
30070582 2018
29
Implementation of a virtual vascular clinic with point-of-care ultrasound in an integrated health care system. 61
29398312 2018
30
Suppressed networks of inflammatory mediators characterize chronic venous insufficiency. 61
29439934 2018
31
Characterization of the complete genome of euonymus yellow vein associated virus, a distinct member of the genus Potexvirus, family Alphaflexiviridae, isolated from Euonymus bungeanus Maxim in Liaoning, Northern China. 61
29079952 2018
32
Cost-effectiveness analysis of five procedures for great saphenous vein reflux in a Norwegian healthcare setting or societal setting. 61
30263121 2018
33
Small RNA-Seq to Characterize Viruses Responsible of Lettuce Big Vein Disease in Spain. 61
30622528 2018
34
Prevalence and Risk Factors for Chronic Venous Disease in the General Russian Population. 61
29031868 2017
35
Truncal varicose vein diameter and patient-reported outcome measures. 61
28766692 2017
36
Incidence of the MTHFR polymorphisms in patients with varicose veins. 61
30944507 2017
37
Development of reliable detection assays for blueberry mosaic- and blackberry vein banding- associated viruses based on their population structures. 61
28754569 2017
38
Characterization of lettuce big-vein associated virus and Mirafiori lettuce big-vein virus infecting lettuce in Saudi Arabia. 61
28299485 2017
39
A new, widespread emaravirus discovered in blackberry. 61
28396285 2017
40
CHIVA - A prospective study of a vein sparing technique for the management of varicose vein disease. 61
28431588 2017
41
First 10-month results of the Vascular Quality Initiative Varicose Vein Registry. 61
28411696 2017
42
Vector Transmission Alone Fails to Explain the Potato Yellow Vein Virus Epidemic among Potato Crops in Colombia. 61
28993785 2017
43
[Lower extremity venous diseases in primary knee osteoarthritis]. 61
28631699 2017
44
Hemodynamics-based treatment of varices: A therapeutic concept counteracting the intrinsic tendency of varicose veins to recur. 61
27581714 2016
45
Nonthermal, Nontumescent Endovenous Treatment of Varicose Veins. 61
27421205 2016
46
Development of marker-free transgenic lettuce resistant to Mirafiori lettuce big-vein virus. 61
27055463 2016
47
A review of a new Dutch guideline for management of recurrent varicose veins. 61
26916778 2016
48
Long-term follow-up for different varicose vein therapies: is surgery still the best? 61
26916779 2016
49
Effects of Fentanyl and Morphine on Shivering During Spinal Anesthesia in Patients Undergoing Endovenous Ablation of Varicose Veins. 61
26871238 2016
50
Real-World Assessment of Interventional Treatment Timing and Outcomes for Varicose Veins: A Retrospective Claims Analysis. 61
26654450 2016

Variations for Vein Disease

Expression for Vein Disease

Search GEO for disease gene expression data for Vein Disease.

Pathways for Vein Disease

Pathways related to Vein Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.03 VEGFA SERPINC1 SERPINA3 PROS1 PROC PLG
2
Show member pathways
12.58 SERPINC1 PROS1 PROC F5 F3 F2
3
Show member pathways
12.03 SERPINA3 PLG MTHFR IL6 F2 CRP
4 11.83 VEGFA IL6 ALB AFP
5
Show member pathways
11.7 SERPINC1 PROS1 PROC PLG F5 F3
6 11.33 SERPINC1 PROS1 PROC PLG F5 F3
7 11.25 F2 ALB AFP
8 10.67 PROS1 PROC F2

GO Terms for Vein Disease

Cellular components related to Vein Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10 VEGFA SST SERPINC1 SERPINA3 PROS1 PROC
2 endoplasmic reticulum lumen GO:0005788 9.87 SERPINC1 PROC IL6 F5 F2 ALB
3 collagen-containing extracellular matrix GO:0062023 9.77 SERPINC1 SERPINA3 PLG F3 F2
4 blood microparticle GO:0072562 9.73 SERPINC1 SERPINA3 PROS1 PLG F2 ALB
5 extracellular space GO:0005615 9.53 VEGFA SST SERPINC1 SERPINA3 PROS1 PROC
6 platelet alpha granule lumen GO:0031093 9.43 VEGFA SERPINA3 PROS1 PLG F5 ALB

Biological processes related to Vein Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.85 SERPINC1 PROC IL6 F5 ALB AFP
2 ER to Golgi vesicle-mediated transport GO:0006888 9.73 PROS1 PROC F5 F2
3 platelet degranulation GO:0002576 9.73 VEGFA SERPINA3 PROS1 PLG F5 ALB
4 blood coagulation GO:0007596 9.7 SERPINC1 PROS1 PROC PLG F5 F3
5 acute-phase response GO:0006953 9.62 SERPINA3 IL6 F2 CRP
6 fibrinolysis GO:0042730 9.58 PROS1 PLG F2
7 cellular protein metabolic process GO:0044267 9.56 SERPINC1 PROC PLG IL6 F5 F2
8 negative regulation of cell-cell adhesion mediated by cadherin GO:2000048 9.49 VEGFA PLG
9 negative regulation of fibrinolysis GO:0051918 9.48 PLG F2
10 negative regulation of lipid storage GO:0010888 9.46 IL6 CRP
11 hemostasis GO:0007599 9.17 SERPINC1 PROS1 PROC PLG F5 F3

Molecular functions related to Vein Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.26 ATP4A ATP12A
2 serine-type endopeptidase activity GO:0004252 9.26 PROC PLG F3 F2
3 potassium-transporting ATPase activity GO:0008556 9.16 ATP4A ATP12A
4 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Vein Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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