Aliases & Classifications for Vein Disease

Summaries for Vein Disease

Disease Ontology : 12 A vascular disease that is located in a vein.

MalaCards based summary : Vein Disease, also known as disorder of vein, is related to varicose veins and venous insufficiency, and has symptoms including vein pain An important gene associated with Vein Disease is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Regulation of lipid metabolism Insulin signaling-generic cascades. The drugs Rivaroxaban and Sodium Tetradecyl Sulfate have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and spinal cord, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Vein Disease

Diseases related to Vein Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 191)
# Related Disease Score Top Affiliating Genes
1 varicose veins 31.8 F2 F5 MTHFR SERPINC1 VEGFA
2 venous insufficiency 31.7 F2 PLAT SERPINE1
3 portal vein thrombosis 31.0 AFP F2 F5 MTHFR SERPINC1 SERPINE1
4 thrombophlebitis 28.9 F2 F5 F8 MTHFR PLAT SERPINC1
5 pulmonary embolism 28.8 ALB F2 F3 F5 MTHFR PLAT
6 thrombosis 28.2 F2 F3 F5 F8 MTHFR PLAT
7 ischemic neuropathy 10.4 F2 MTHFR
8 hemoglobin e disease 10.4 F2 F5
9 abdominal tuberculosis 10.3 ALB F2
10 hepatic tuberculosis 10.3 ALB F2
11 endometrial small cell carcinoma 10.3 AFP F2
12 yellow nail syndrome 10.3 ALB SST
13 qualitative platelet defect 10.3 F2 F3
14 vitreous detachment 10.3 PLG VEGFA
15 paracetamol poisoning 10.3 F2 F5
16 antipyrine metabolism 10.3 ALB F2
17 non-a-e hepatitis 10.3 ALB F2
18 heparin-induced thrombocytopenia 10.3 F3 SERPINC1
19 arteritic anterior ischemic optic neuropathy 10.3 F2 F5 MTHFR
20 sudden sensorineural hearing loss 10.2 F2 F5 MTHFR
21 prothrombin deficiency 10.2 F2 F3
22 aspirin allergy 10.2 SERPINC1 SERPINE1
23 porencephaly 10.2 F2 F5 MTHFR
24 factor v and factor viii, combined deficiency of, 2 10.2 F5 F8
25 epstein-barr virus hepatitis 10.2 ALB F2
26 gastroschisis 10.2 F2 F5 MTHFR
27 prothrombin deficiency, congenital 10.2 F2 F5 SERPINC1
28 tuberculous empyema 10.2 PLG SERPINE1
29 acute liver failure 10.2 ALB F2 F5
30 hypersplenism 10.2 ALB F2 SERPINC1
31 alpha-2-plasmin inhibitor deficiency 10.2 F2 PLG SERPINC1
32 platelet aggregation, spontaneous 10.2 PLAT SERPINC1
33 hemifacial spasm 10.2 MTHFR VEGFA
34 spinal cord infarction 10.2 F2 F5 MTHFR SERPINC1
35 anterior spinal artery syndrome 10.2 F2 PLG SERPINC1
36 cerebral palsy 10.2 F2 F5 MTHFR
37 antithrombin iii deficiency 10.2 F2 F5 MTHFR SERPINC1
38 placental abruption 10.2 F2 F5 MTHFR SERPINC1
39 ischemic optic neuropathy 10.2 F2 F5 MTHFR SERPINC1
40 inferior vena cava interruption 10.2 F5 MTHFR SERPINE1
41 nonarteritic anterior ischemic optic neuropathy 10.2 F2 F5 MTHFR SERPINC1
42 eclampsia 10.2 ALB F2 MTHFR SERPINC1
43 central retinal artery occlusion 10.2 PLAT PLG
44 inferior myocardial infarction 10.2 PLAT PLG
45 amaurosis fugax 10.2 F5 MTHFR SERPINE1
46 conjugate gaze palsy 10.1 F3 PLG
47 ovarian hyperstimulation syndrome 10.1 ALB F5 VEGFA
48 peliosis hepatis 10.1 AFP F2 VEGFA
49 neonatal stroke 10.1 MTHFR PROC SERPINE1
50 homocystinuria 10.1 F5 MTHFR SERPINC1

Graphical network of the top 20 diseases related to Vein Disease:



Diseases related to Vein Disease

Symptoms & Phenotypes for Vein Disease

UMLS symptoms related to Vein Disease:


vein pain

MGI Mouse Phenotypes related to Vein Disease:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.47 ADAM17 AFP ALB BLOC1S2 EPAS1 F2
2 cardiovascular system MP:0005385 10.4 ADAM17 BLOC1S2 EPAS1 F2 F3 F5
3 mortality/aging MP:0010768 10.38 ADAM17 AFP ALB BLOC1S2 EPAS1 F2
4 growth/size/body region MP:0005378 10.34 ADAM17 EPAS1 F2 F3 F5 MTHFR
5 hematopoietic system MP:0005397 10.32 ADAM17 BLOC1S2 EPAS1 F2 F3 F8
6 immune system MP:0005387 10.26 ADAM17 EPAS1 F2 F3 F8 PLAT
7 embryo MP:0005380 10.24 ADAM17 BLOC1S2 EPAS1 F2 F3 F5
8 liver/biliary system MP:0005370 10.21 AFP ALB BLOC1S2 EPAS1 F5 MTHFR
9 integument MP:0010771 10.16 ADAM17 F2 F3 F5 MTHFR PLAT
10 nervous system MP:0003631 10.1 ADAM17 BLOC1S2 EPAS1 F2 F3 F5
11 digestive/alimentary MP:0005381 10.09 ADAM17 ALB F2 PLAT PLG SST
12 muscle MP:0005369 10.02 ADAM17 ALB EPAS1 F3 PARVA PLAT
13 reproductive system MP:0005389 9.81 ADAM17 AFP F2 F8 MTHFR PLAT
14 neoplasm MP:0002006 9.8 AFP ALB F3 PLG SERPINE1 VEGFA
15 respiratory system MP:0005388 9.61 ADAM17 EPAS1 F2 F3 PLAT PLG
16 vision/eye MP:0005391 9.28 ADAM17 BLOC1S2 EPAS1 F3 MTHFR PLAT

Drugs & Therapeutics for Vein Disease

Drugs for Vein Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 93)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rivaroxaban Approved Phase 4,Phase 3 366789-02-8
2
Sodium Tetradecyl Sulfate Approved, Investigational Phase 4,Not Applicable 1191-50-0, 139-88-8 5248 14492
3
Racepinephrine Approved Phase 4 329-65-7 838
4
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
5
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
6
Polidocanol Approved Phase 4 9002-92-0
7
Serine Approved, Nutraceutical Phase 4,Phase 3 56-45-1 5951
8 Aminaftone Phase 4
9 Coagulants Phase 4,Phase 3
10 Hemostatics Phase 4,Phase 3
11 Pharmaceutical Solutions Phase 4,Not Applicable
12 Serine Proteinase Inhibitors Phase 4,Phase 3
13 Antithrombin III Phase 4,Phase 3
14 HIV Protease Inhibitors Phase 4,Phase 3
15 Anticoagulants Phase 4,Phase 3,Phase 2
16 Antithrombins Phase 4,Phase 3
17 Factor Xa Inhibitors Phase 4,Phase 3
18
protease inhibitors Phase 4,Phase 3
19 Anti-Inflammatory Agents Phase 4,Not Applicable
20 Calamus Phase 4,Not Applicable
21 Anti-Asthmatic Agents Phase 4
22 Neurotransmitter Agents Phase 4
23 Adrenergic beta-Agonists Phase 4
24 Anti-Arrhythmia Agents Phase 4
25 Adrenergic Agents Phase 4
26 Diuretics, Potassium Sparing Phase 4
27 Anesthetics Phase 4
28 Epinephryl borate Phase 4
29 Mydriatics Phase 4
30 Adrenergic alpha-Agonists Phase 4
31 Sympathomimetics Phase 4
32 Adrenergic Agonists Phase 4
33 Peripheral Nervous System Agents Phase 4
34 Sodium Channel Blockers Phase 4
35 Respiratory System Agents Phase 4
36 Central Nervous System Depressants Phase 4
37 Autonomic Agents Phase 4
38 Bronchodilator Agents Phase 4
39 Anesthetics, Local Phase 4
40 Vasoconstrictor Agents Phase 4
41
Warfarin Approved Phase 3 81-81-2 6691 54678486
42
Tinzaparin Approved Phase 3 9005-49-6, 9041-08-1 25244225
43
Enoxaparin Approved Phase 3 9005-49-6 772
44
Heparin Approved, Investigational Phase 3,Not Applicable 9005-49-6 772 46507594
45
Dalteparin Approved Phase 3 9005-49-6
46
Nadroparin Approved, Investigational Phase 3
47
Becaplermin Approved, Investigational Phase 3 165101-51-9
48
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
49 calcium heparin Phase 3,Not Applicable
50 Tissue Plasminogen Activator Phase 3

Interventional clinical trials:

(show top 50) (show all 79)
# Name Status NCT ID Phase Drugs
1 Compression Aided Management of Edema in Patients With C3 Venous Disease Unknown status NCT00766974 Phase 4
2 Efficacy on Pain Following a Procedure for Injecting Sclerotherapeutic Foam Into the Great Saphenous Vein Completed NCT01368159 Phase 4
3 ClosureFAST vs. Laser Ablation for the Treatment of GSV Disease: A Multicenter, Single-Blinded, Randomized Study. Completed NCT00509392 Phase 4
4 Iliac Vein Stenting in Advanced Chronic Venous Insufficiency Completed NCT02149212 Phase 4 Phlebotonic
5 Laser Ablation Versus Mechanochemical Ablation Trial Recruiting NCT02627846 Phase 4 Lidocaine with 1:200,000 epinephrine solution;Lidocaine with 1:200,000 epinephrine solution;Sodium Bicarbonate;Sodium Tetradecyl Sulphate
6 Rivaroxaban With Diosmine in Long-term Treatment of DVT Active, not recruiting NCT03413618 Phase 4 Rivaroxaban;Diosmin
7 Study of Antiinflammatory Effects of Detralex (Daflon) Enrolling by invitation NCT01654016 Phase 4 Detralex
8 Effect of PEM Treatment of Superficial Axial and Tributary Vein Reflux on Improvement of Wound Healing in VLUs Withdrawn NCT02988063 Phase 4 Polidocanol Endovenous Microfoam (PEM)
9 RCT Comparing Standard Cannula Delivered FS, UGFS and ClariVein® in the Management of SVI Withdrawn NCT02010437 Phase 4 Sodium Tetradecyl Sulphate (STS)
10 Efficacy and Safety of Diosmin 600mg Versus Placebo on Painful Symptomatology in Patients With Chronic Venous Disease of Lower Limbs Completed NCT01532882 Phase 3 Diosmin;Placebo
11 The Influence of Compression Stockings on Skin's Barrier Function at Patients With Chronic Venous Disease Completed NCT00196443 Phase 2, Phase 3
12 Efficacy on Volume Reduction and Tolerance of Progressiv' Medical Compressive Therapy (MCT) V0322 BC in Patients With Chronic Venous Oedema Completed NCT01402921 Phase 3
13 Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis Completed NCT00790335 Phase 3 Recombinant tissue plasminogen activator (rt-PA)
14 The SOX Trial: Compression Stockings to Prevent the Post-Thrombotic Syndrome Completed NCT00143598 Phase 3
15 Randomized Controlled Trial of Anticoagulation vs. Placebo for a First Symptomatic Isolated Distal Deep-vein Thrombosis (IDDVT) Completed NCT00421538 Phase 3 nadroparine calcium;Placebo
16 Rivaroxaban Anticoagulation for Superficial Vein Thrombosis Completed NCT02123524 Phase 3 Rivaroxaban;Placebo
17 Crenobalneotherapy in the Treatment of Chronic Venous Insufficiency Completed NCT01956318 Phase 3
18 PRP ULCERAS: Clinical Trial Phase III Active, not recruiting NCT02213952 Phase 3 Platelet-Rich Plasma
19 Study of Combined Topical Growth Factor and Protease Inhibitor in Chronic Wound Healing Not yet recruiting NCT02845466 Phase 3
20 Calcium Dobesilate for Chronic Venous Wounds Suspended NCT00979836 Phase 3 Calcium Dobesilate
21 Great Saphenous Vein Electrocoagulation Unknown status NCT02139085 Phase 2
22 Non-Healing Ulcers Without Critical Limb Ischemia Unknown status NCT01666093 Phase 2
23 Treatment of Claudication With a Peristaltic Pulse Pneumatic Device Unknown status NCT01007604 Phase 2
24 Surface NeuroMuscular Electrical Stimulation in the Treatment of Chronic Venous Leg Ulcers Completed NCT01801891 Phase 2
25 Cooling Lower Leg Skin to Prevent Venous Leg Ulcers in Patients With Poor Vein Circulation Completed NCT01509599 Phase 1, Phase 2
26 Physical Conditioning in Management of Chronic Venous Insufficiency Completed NCT00013273 Phase 2
27 Mesoglycan (Prisma®) Versus Placebo in Secondary Prevention of the Superficial Venous Thrombosis Recruiting NCT03428711 Phase 2 Mesoglycan Oral Tablet;Placebo Oral Tablet
28 EXPLORATORY ASSESSMENT OF THE EFFECTS OF CYCLO 3 ® FORT (Ruscus Extract, Hesperidin Methyl Chalcone, Ascorbic Acid) OR MICRONISED PURIFIED FLAVONOID FRACTION ON VASCULAR PARAMETERS AND BIOMARKERS IN WOMEN SUFFERING FROM CHRONIC VENOUS DISEASE (CEAP C2 OR C3), OVER 8 WEEKS Withdrawn NCT02907320 Phase 2 CYCLO 3 ® FORT;MPFF;placebo CYCLO 3 ® FORT;placebo MPFF
29 Tissue Engineered Veins in Patients With Chronic Venous Insufficiency Not yet recruiting NCT03784131 Phase 1 P-TEV
30 Elastic Compression in Chronic Venous Disease Unknown status NCT02641600 Not Applicable
31 Venous Pressure Measurement of the Great Saphenous Vein Using Controlled Compression Ultrasound in Healthy Persons and Patients With Chronic Venous Disease as a New Non Invasive Method for Investigation of the Pathophysiology in Primary Varicose Veins Unknown status NCT01000909
32 Prevalence of Onychodystrophy in Patients With Chronic Venous Disease of the Lower Limbs Completed NCT02731222
33 Evaluating the Occurence of New and Progression of Existing Peripheral Venous Disease in Leg Veins Completed NCT00508079
34 Prevalence of MTHFR Polymorphisms in Venous Disease Completed NCT01993914
35 Estrogen Receptors and Chronic Venous Disease Completed NCT02558426
36 FOAM-study, Cost Minimization Study Comparing Surgery Versus Duplex Guided Foam Sclerotherapy of Varicose Veins Completed NCT01103258 Not Applicable
37 Epidemiology of Venous Disease Completed NCT00005392
38 Venous Insufficiency and Neuromuscular Stimulation Completed NCT02137499 Not Applicable
39 Pen Torch Transillumination: Shedding Light on Difficult Venepuncture Completed NCT02570568 Not Applicable
40 Treatment of Insufficient Superficial and Perforating Veins of the Lower Limb Using HIFU Completed NCT03304834 Not Applicable
41 Copper Impact on Venous Insufficiency and Lipodermatosclerosis Completed NCT03283800 Not Applicable
42 LLLT of Trophic Ulcers of Lower Extremities and Chronic Venous Insufficiency Completed NCT03104985 Not Applicable
43 Manual Lymphatic Drainage in Chronic Venous Insufficiency: a Randomized Controlled Trial Completed NCT01899482 Not Applicable
44 Evaluating the Relationship Between Blood Clotting Disorders, Inflammation, and Obesity in Individuals With Venous Disorders and Post-Thrombotic Syndrome Completed NCT00395265
45 Compression Therapy Versus Surgery in the Treatment of Superficial Venous Reflux Completed NCT01701661 Not Applicable
46 Non-Invasive Management of Chronic Venous Insufficiency Completed NCT00950378
47 Safety and Efficacy of Endovenous Laser Ablation for the Resolution of Incompetent Perforator Veins Completed NCT00565604 Not Applicable
48 ClosureFAST - Radiofrequency Great Saphenous Vein Treatment Completed NCT00842296 Not Applicable
49 New Genetic Mutations in Thromboembolic Venous Disease Idiopathic. Study "FIT GENETIQUE". Recruiting NCT02841085
50 Ongoing Registry of Treatment of Chronic Venous Diseases Recruiting NCT03035747

Search NIH Clinical Center for Vein Disease

Genetic Tests for Vein Disease

Anatomical Context for Vein Disease

MalaCards organs/tissues related to Vein Disease:

41
Liver, Heart, Spinal Cord, Pancreas, Thyroid, Placenta

The Foundational Model of Anatomy Ontology organs/tissues related to Vein Disease:

19
A Vein

Publications for Vein Disease

Articles related to Vein Disease:

(show all 44)
# Title Authors Year
1
Present and future options for treatment of infrainguinal deep vein disease. ( 30007531 )
2018
2
DNA methylation and gene expression profiling reveal MFAP5 as a regulatory driver of extracellular matrix remodeling in varicose vein disease. ( 30070582 )
2018
3
Early clinical experience using telemedicine for the management of patients with varicose vein disease. ( 28969485 )
2017
4
Commentary on the article "A prospective study of a vein sparing technique for the management of varicose vein disease" by M Zmudzinski etA al. ( 29122236 )
2017
5
CHIVA - A prospective study of a vein sparing technique for the management of varicose vein disease. ( 28431588 )
2017
6
Guidelines of the First International Consensus Conference on Endovenous Thermal Ablation for Varicose Vein Disease - ETAV Consensus Meeting 2012. ( 24534341 )
2014
7
Evaluation of apoptosis in varicose vein disease complicated by superficial vein thrombosis. ( 25007903 )
2014
8
Cost analysis of endovenous catheter ablation versus surgical stripping for treatment of superficial venous insufficiency and varicose vein disease. ( 26992979 )
2014
9
Molecular characterization and population structure of blackberry vein banding associated virus, new Ampelovirus associated with yellow vein disease. ( 24126200 )
2013
10
Platelet distribution width and saphenous vein disease in patients after CABG. Association with graft occlusion. ( 22955688 )
2013
11
A review of familial, genetic, and congenital aspects of primary varicose vein disease. ( 22896013 )
2012
12
The hemodynamic paradox as a phenomenon triggering recurrent reflux in varicose vein disease. ( 23997567 )
2012
13
The significance of upper arm cephalic vein disease in vascular access creation. ( 23020965 )
2012
14
Molecular and biological characterization of pepper yellow vein Mali virus (PepYVMV) isolates associated with pepper yellow vein disease in Burkina Faso. ( 21080204 )
2011
15
Increased vein wall apoptosis in varicose vein disease is related to venous hypertension. ( 21262580 )
2011
16
Superficial thrombophlebitis in varicose vein disease: the particular role of methylenetetrahydrofolate reductase. ( 20881312 )
2011
17
Superficial thrombophlebitis in varicose vein disease: the particular role of methylenetetrahydrofolate reductase. ( 21690171 )
2011
18
Endovenous laser ablation for the treatment of recurrent varicose vein disease--a single centre experience. ( 20227536 )
2010
19
Pathogenic mechanisms in varicose vein disease: the role of hypoxia and inflammation. ( 20632821 )
2010
20
Chronic venous insufficiency: current management of varicose vein disease. ( 20336886 )
2010
21
Minimally invasive vein surgery: latest options for vein disease. ( 20506452 )
2010
22
Further evidence of Mirafiori lettuce big-vein virus but not of Lettuce big-vein associated virus with big-vein disease in lettuce. ( 18944196 )
2008
23
Commentary on "The economics of vein disease". ( 17911566 )
2007
24
Changes in the wall of the great saphenous vein at consecutive stages in patients suffering from chronic vein disease of the lower limbs. ( 17985316 )
2007
25
The economics of vein disease. ( 17911565 )
2007
26
A begomovirus associated with Ageratum yellow vein disease in Indonesia: evidence for natural recombination between tomato leaf curl Java virus and Ageratum yellow vein virus-[Java]. ( 17294343 )
2007
27
Surgical correction of varicose vein disease under micronized diosmin protection (results of the Russian multicenter controlled trial DEFANS). ( 18004259 )
2007
28
Selection of saphenous vein conduit in varicose vein disease. ( 16564256 )
2006
29
The histopathology of varicose vein disease. ( 17067976 )
2006
30
The DNA beta satellite component associated with ageratum yellow vein disease encodes an essential pathogenicity protein (betaC1). ( 15183051 )
2004
31
Nucleotide sequence and genomic organization of an ophiovirus associated with lettuce big-vein disease. ( 12388823 )
2002
32
Adaptation from whitefly to leafhopper transmission of an autonomously replicating nanovirus-like DNA component associated with ageratum yellow vein disease. ( 11907341 )
2002
33
Pathogenicity of a natural recombinant associated with ageratum yellow vein disease: implications for geminivirus evolution and disease aetiology. ( 11259188 )
2001
34
A unique virus complex causes Ageratum yellow vein disease. ( 10841581 )
2000
35
A nanovirus-like DNA component associated with yellow vein disease of Ageratum conyzoides: evidence for interfamilial recombination between plant DNA viruses. ( 10544139 )
1999
36
Symptomatology of vein disease. ( 7728483 )
1995
37
Unsuspected preexisting saphenous vein disease: an unrecognized cause of vein bypass failure. ( 1728668 )
1992
38
The management of varicose vein disease. ( 287952 )
1979
39
The modern treatment of varicose vein disease. ( 4520459 )
1973
40
Phlebography in varicose vein disease. ( 5014478 )
1972
41
Mesenteric vein disease. ( 13740328 )
1961
42
Yellow-vein disease of citrus and studies of interactions between yellow-vein and other viruses of citrus. ( 13843232 )
1960
43
Pulmonary embolism; its incidence, significance, and relation to antecedent vein disease. ( 18111784 )
1949
44
Pulmonary embolism; its incidence, significance, and relation to antecedent vein disease. ( 18877800 )
1948

Variations for Vein Disease

Expression for Vein Disease

Search GEO for disease gene expression data for Vein Disease.

Pathways for Vein Disease

Pathways related to Vein Disease according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 ALB F2 F3 F5 F8 PLAT
2
Show member pathways
12.72 ADAM17 PLAT PLG SERPINE1 VEGFA
3
Show member pathways
12.59 F2 F3 F5 F8 PROC PROS1
4
Show member pathways
12.07 ALB F2 MTHFR PLAT PLG SERPINE1
5 11.85 F3 PARVA PLG SERPINE1
6 11.8 F2 F3 F5 F8 PLAT PLG
7
Show member pathways
11.77 F2 PROC PROS1
8 11.71 F3 SERPINE1 VEGFA
9
Show member pathways
11.52 F2 F3 F5 F8 PLAT PLG
10 11.49 PLAT PLG SERPINE1
11 11.38 PLAT PLG VEGFA
12 11.31 AFP ALB F2
13 11.18 EPAS1 SERPINE1 VEGFA
14 10.97 ADAM17 PLAT PLG
15 10.83 PLAT VEGFA
16 10.8 EPAS1 VEGFA
17 10.76 F2 PROC PROS1
18 10.66 PLAT PLG SERPINE1

GO Terms for Vein Disease

Cellular components related to Vein Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.83 ADAM17 F3 PLAT PLG VEGFA
2 endoplasmic reticulum lumen GO:0005788 9.8 AFP ALB F2 F5 F8 PROC
3 extracellular space GO:0005615 9.8 AFP ALB F2 F3 F5 F8
4 collagen-containing extracellular matrix GO:0062023 9.77 F3 PLAT PLG SERPINC1 SERPINE1
5 blood microparticle GO:0072562 9.72 ALB F2 PLG PROS1 SERPINC1
6 Golgi lumen GO:0005796 9.58 F2 PROC PROS1
7 platelet alpha granule lumen GO:0031093 9.17 ALB F5 F8 PLG PROS1 SERPINE1
8 extracellular region GO:0005576 10 AFP ALB F2 F3 F5 F8

Biological processes related to Vein Disease according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 ER to Golgi vesicle-mediated transport GO:0006888 9.88 F2 F5 F8 PROC PROS1
2 post-translational protein modification GO:0043687 9.88 AFP ALB EPAS1 F5 PROC SERPINC1
3 cellular protein metabolic process GO:0044267 9.87 AFP ALB F2 F5 PLG PROC
4 response to hypoxia GO:0001666 9.83 ADAM17 EPAS1 MTHFR PLAT VEGFA
5 platelet degranulation GO:0002576 9.7 ALB F5 F8 PLG PROS1 SERPINE1
6 fibrinolysis GO:0042730 9.65 F2 PLAT PLG PROS1 SERPINE1
7 negative regulation of blood coagulation GO:0030195 9.63 PROC PROS1 SERPINE1
8 blood coagulation GO:0007596 9.61 F2 F3 F5 F8 PLAT PLG
9 blood coagulation, intrinsic pathway GO:0007597 9.56 F2 F8
10 positive regulation of blood coagulation GO:0030194 9.55 F2 SERPINE1
11 regulation of blood coagulation GO:0030193 9.54 F2 SERPINC1
12 negative regulation of fibrinolysis GO:0051918 9.54 F2 PLG SERPINE1
13 positive regulation of positive chemotaxis GO:0050927 9.52 F3 VEGFA
14 surfactant homeostasis GO:0043129 9.51 EPAS1 VEGFA
15 positive regulation of cellular component movement GO:0051272 9.49 ADAM17 VEGFA
16 hemostasis GO:0007599 9.23 F2 F3 F5 F8 PLG PROC

Molecular functions related to Vein Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.72 ADAM17 F2 PLAT PLG PROC
2 protease binding GO:0002020 9.54 F3 SERPINC1 SERPINE1
3 copper ion binding GO:0005507 9.33 ALB F5 F8
4 serine-type peptidase activity GO:0008236 9.26 F2 PLAT PLG PROC
5 serine-type endopeptidase activity GO:0004252 9.02 F2 F3 PLAT PLG PROC
6 protein binding GO:0005515 10.16 ADAM17 AFP ALB BLOC1S2 EPAS1 F2

Sources for Vein Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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