MCID: VND001
MIFTS: 43

Vein Disease

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Vein Disease

MalaCards integrated aliases for Vein Disease:

Name: Vein Disease 12 15
Disorder of Vein 71

Classifications:



External Ids:

Disease Ontology 12 DOID:866
ICD9CM 34 453
UMLS 71 C0155774 C0235522

Summaries for Vein Disease

Disease Ontology : 12 A vascular disease that is located in a vein.

MalaCards based summary : Vein Disease, also known as disorder of vein, is related to varicose veins and venous insufficiency, and has symptoms including vein pain An important gene associated with Vein Disease is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Ethanol and Heparin have been mentioned in the context of this disorder. Affiliated tissues include a vein, lymph node and heart, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Vein Disease

Diseases in the Vein Disease family:

Congenital Systemic Veins Anomaly

Diseases related to Vein Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 432)
# Related Disease Score Top Affiliating Genes
1 varicose veins 32.8 VEGFA SERPINC1 MTHFR F5 F2
2 venous insufficiency 32.8 VEGFA MTHFR F5 F2 CRP
3 chronic venous insufficiency 30.6 VEGFA MTHFR F2 CRP
4 pulmonary embolism 30.1 SERPINC1 PROS1 PROC MTHFR F5 F3
5 protein s deficiency 30.0 SERPINC1 PROS1 PROC MTHFR F5 F3
6 thrombophlebitis 29.9 SERPINC1 PROS1 PROC PLG MTHFR F5
7 thrombosis 29.8 SERPINC1 PROS1 PROC PLG MTHFR F5
8 body mass index quantitative trait locus 11 29.5 VEGFA PROC PLG GPT CRP ALB
9 non-a-e hepatitis 10.8 F2 ALB
10 antipyrine metabolism 10.8 F2 ALB
11 paracetamol poisoning 10.8 F5 F2
12 prothrombin-related thrombophilia 10.8 MTHFR F2
13 arteritic anterior ischemic optic neuropathy 10.8 MTHFR F5 F2
14 amaurosis fugax 10.8 MTHFR F5
15 neonatal stroke 10.8 PROC MTHFR
16 orbital osteomyelitis 10.7 F2 CRP
17 hepatoportal sclerosis 10.7 GPT F2
18 femoral vein thrombophlebitis 10.7 PROC F2
19 cryptogenic cirrhosis 10.7 MTHFR F5 F2
20 hemifacial spasm 10.7 VEGFA MTHFR
21 dipetalonemiasis 10.7 GPT ALB
22 small intestine diverticulitis 10.7 F2 CRP
23 lateral sinus thrombosis 10.7 SERPINC1 MTHFR F2
24 cholecystitis 10.7 GPT F2 ALB
25 prothrombin deficiency, congenital 10.7 SERPINC1 F5 F2
26 acquired hemophilia 10.7 F5 F3
27 acquired hemophilia a 10.7 F5 F3
28 chronic duodenal ileus 10.7 CRP ALB
29 sticky platelet syndrome 10.7 SERPINC1 F5
30 porencephaly 10.7 MTHFR F5 F2
31 meningococcemia 10.7 SERPINC1 PROC F5
32 cardiac tuberculosis 10.7 SERPINC1 CRP
33 acquired angioedema 10.7 F5 CRP
34 hepatic tuberculosis 10.7 GPT F2 ALB
35 heparin-induced thrombocytopenia 10.7 SERPINC1 F3
36 sneddon syndrome 10.7 SERPINC1 F5 F2
37 vulvar angiokeratoma 10.7 SERPINC1 F3
38 dic in newborn 10.7 SERPINC1 F3 F2
39 papillary adenofibroma 10.7 F3 F2 AFP
40 hypertensive encephalopathy 10.7 VEGFA F2 ALB
41 dysfibrinogenemia, congenital 10.7 SERPINC1 F5 F2
42 infantile liver failure syndrome 1 10.7 GPT F2 ALB
43 liver leiomyosarcoma 10.7 GPT F2 AFP
44 heterophyiasis 10.7 GPT ALB
45 prothrombin deficiency 10.7 SERPINC1 F3 F2
46 pancreatic vasoactive intestinal peptide producing tumor 10.7 ATP4A ATP12A
47 waterhouse-friderichsen syndrome 10.7 SERPINC1 F2
48 thoracic outlet syndrome 10.7 SERPINC1 PLG F2
49 volkmann contracture 10.7 SERPINC1 F3 F2
50 legg-calve-perthes disease 10.7 SERPINC1 MTHFR F5

Graphical network of the top 20 diseases related to Vein Disease:



Diseases related to Vein Disease

Symptoms & Phenotypes for Vein Disease

UMLS symptoms related to Vein Disease:


vein pain

MGI Mouse Phenotypes related to Vein Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 AFP ALB ATP12A ATP4A CRP EPAS1
2 cardiovascular system MP:0005385 10.22 ALB CRP EPAS1 EVL F2 F3
3 hematopoietic system MP:0005397 10.15 ATP4A EPAS1 EVL F2 F3 MFAP5
4 immune system MP:0005387 10.07 ALB ATP4A CRP EPAS1 EVL F2
5 mortality/aging MP:0010768 9.86 AFP ALB ATP4A EPAS1 EVL F2
6 liver/biliary system MP:0005370 9.85 AFP ALB EPAS1 F5 MTHFR PLG
7 nervous system MP:0003631 9.4 EPAS1 EVL F2 F3 F5 MTHFR

Drugs & Therapeutics for Vein Disease

Drugs for Vein Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved 64-17-5 702
2
Heparin Approved, Investigational 9005-49-6 772 46507594
3
Polidocanol Approved 9002-92-0
4
Sodium Tetradecyl Sulfate Approved, Investigational 1191-50-0, 139-88-8 14492 5248
5 Calamus
6 calcium heparin
7 Sclerosing Solutions
8 Pharmaceutical Solutions

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 FOAM-study Cost Minimization Study Comparing Surgery Versus Duplex Guided Foam Sclerotherapy of Varicose Veins: a Randomized Controlled Study Completed NCT01103258
2 Pen Torch Transillumination: Shedding Light on Difficult Venepuncture Completed NCT02570568
3 Pilot Randomised Controlled Trial Evaluating the Potential Benefit of a One Stop Vein Clinic (OSVeC) Recruiting NCT02557542 Foam sclerotherapy (Polidocanol or Sodium Tetradecyl Sulphate)
4 Allogeneic Left Atrial and Pulmonary Vein Transplant for Pulmonary Vein Stenosis Recruiting NCT03456193
5 The Role of Pyroptosis in Chronic Venous Disease and Its Pathophysiological Implication Active, not recruiting NCT03744858
6 Patients Commitment to Compression Therapy Not yet recruiting NCT04096729

Search NIH Clinical Center for Vein Disease

Genetic Tests for Vein Disease

Anatomical Context for Vein Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Vein Disease:

19
A Vein

MalaCards organs/tissues related to Vein Disease:

40
Lymph Node, Heart, Liver, Skin, Myeloid, Neutrophil

Publications for Vein Disease

Articles related to Vein Disease:

(show top 50) (show all 199)
# Title Authors PMID Year
1
FEATURES OF CLINICAL SYMPTOMS AND SIGNS, HEMATOLOGICAL AND BIOCHEMICAL PARAMETERS IN CHILDREN WITH JOINT HYPERMOBILITY IN A LATE PERIOD UPON THE CHORNOBYL NPP ACCIDENT. 61
31841477 2019
2
Single- versus multiple-stage catheter-directed thrombolysis for acute iliofemoral deep venous thrombosis does not have an impact on iliac vein stent length or patency rates. 61
31495769 2019
3
[Thromboembolic vein disease (TVD): antithrombotic therapy choice in ASL TO3.] 61
31593179 2019
4
Lower Extremity Venous Stent Placement: A Large Retrospective Single-Center Analysis. 61
31542273 2019
5
Surgical and endovascular central venous reconstruction combined with thoracic outlet decompression in highly symptomatic patients. 61
30442583 2019
6
[Venous wall weackness pathogenesis in varicose vein disease]. 61
31626242 2019
7
Early clinical experience using telemedicine for the management of patients with varicose vein disease. 61
28969485 2019
8
Clinical and Genetic Determinants of Varicose Veins. 61
30566020 2018
9
Commentary on the article "A prospective study of a vein sparing technique for the management of varicose vein disease" by M Zmudzinski et al. 61
29122236 2018
10
Molecular characterization and detection of a novel vitivirus infecting blackberry. 61
29987381 2018
11
Present and future options for treatment of infrainguinal deep vein disease. 61
30007531 2018
12
The effectiveness of various interventions versus standard stripping in patients with varicose veins in terms of quality of life. 61
28720052 2018
13
DNA methylation and gene expression profiling reveal MFAP5 as a regulatory driver of extracellular matrix remodeling in varicose vein disease. 61
30070582 2018
14
Cumulative Effect of Preoperative Risk Factors on Mortality After Pediatric Heart Transplantation. 61
29684375 2018
15
Implementation of a virtual vascular clinic with point-of-care ultrasound in an integrated health care system. 61
29398312 2018
16
Suppressed networks of inflammatory mediators characterize chronic venous insufficiency. 61
29439934 2018
17
Characterization of the complete genome of euonymus yellow vein associated virus, a distinct member of the genus Potexvirus, family Alphaflexiviridae, isolated from Euonymus bungeanus Maxim in Liaoning, Northern China. 61
29079952 2018
18
Cost-effectiveness analysis of five procedures for great saphenous vein reflux in a Norwegian healthcare setting or societal setting. 61
30263121 2018
19
Small RNA-Seq to Characterize Viruses Responsible of Lettuce Big Vein Disease in Spain. 61
30622528 2018
20
Prevalence and Risk Factors for Chronic Venous Disease in the General Russian Population. 61
29031868 2017
21
Truncal varicose vein diameter and patient-reported outcome measures. 61
28766692 2017
22
Incidence of the MTHFR polymorphisms in patients with varicose veins. 61
30944507 2017
23
Development of reliable detection assays for blueberry mosaic- and blackberry vein banding- associated viruses based on their population structures. 61
28754569 2017
24
Characterization of lettuce big-vein associated virus and Mirafiori lettuce big-vein virus infecting lettuce in Saudi Arabia. 61
28299485 2017
25
CHIVA - A prospective study of a vein sparing technique for the management of varicose vein disease. 61
28431588 2017
26
First 10-month results of the Vascular Quality Initiative Varicose Vein Registry. 61
28411696 2017
27
A new, widespread emaravirus discovered in blackberry. 61
28396285 2017
28
Vector Transmission Alone Fails to Explain the Potato Yellow Vein Virus Epidemic among Potato Crops in Colombia. 61
28993785 2017
29
[Lower extremity venous diseases in primary knee osteoarthritis]. 61
28631699 2017
30
Hemodynamics-based treatment of varices: A therapeutic concept counteracting the intrinsic tendency of varicose veins to recur. 61
27581714 2016
31
Nonthermal, Nontumescent Endovenous Treatment of Varicose Veins. 61
27421205 2016
32
Development of marker-free transgenic lettuce resistant to Mirafiori lettuce big-vein virus. 61
27055463 2016
33
A review of a new Dutch guideline for management of recurrent varicose veins. 61
26916778 2016
34
Long-term follow-up for different varicose vein therapies: is surgery still the best? 61
26916779 2016
35
Effects of Fentanyl and Morphine on Shivering During Spinal Anesthesia in Patients Undergoing Endovenous Ablation of Varicose Veins. 61
26871238 2016
36
Radiofrequency ablation or stripping of large-diameter incompetent great saphenous varicose veins with C2 or C3 disease. 61
26946895 2016
37
Real-World Assessment of Interventional Treatment Timing and Outcomes for Varicose Veins: A Retrospective Claims Analysis. 61
26654450 2016
38
[The influence of the training of the muscular component of the musculo-venous pump in the lower extremities on the clinical course of varicose vein disease]. 61
28091490 2016
39
ICD Leads Extraction and Clearing of Access Way in a Patient With Superior Vena Cava Syndrome: Building A Tunnel. 61
26402803 2015
40
Management of perforator vein aneurysms in the lower extremities. 61
26992305 2015
41
NONICHEMIC CENTRAL RETINAL VEIN OCCLUSION ASSOCIATED WITH HEREDITARY THROMBOPHYLIA. 61
26978887 2015
42
Association of tomato leaf curl New Delhi virus DNA-B with bhendi yellow vein mosaic virus in okra showing yellow vein mosaic disease symptoms. 61
26104329 2015
43
Thrombophilic mutations as risk factor for retinal vein occlusion: a case-control study. 61
24569626 2015
44
Guidelines of the First International Consensus Conference on Endovenous Thermal Ablation for Varicose Vein Disease--ETAV Consensus Meeting 2012. 61
24534341 2015
45
Spliced arm vein grafts are a durable conduit for lower extremity bypass. 61
25638725 2015
46
[MECHANISMS OF DEVELOPMENT OF INCOMPETENT PERFORATING VEINS IN PATIENTS WITH VARICOSE VEIN DISEASE OF LOWER LIMBS]. 61
26390582 2015
47
Brachiocephalic Vein Stenting and Body-Floss Technique as a Treatment of CVD in Dialysis-Dependent Patient - Case Report and Literature Review. 61
26000070 2015
48
The VANISH-2 study: a randomized, blinded, multicenter study to evaluate the efficacy and safety of polidocanol endovenous microfoam 0.5% and 1.0% compared with placebo for the treatment of saphenofemoral junction incompetence. 61
23864535 2014
49
Evaluation of apoptosis in varicose vein disease complicated by superficial vein thrombosis. 61
25007903 2014
50
Inequalities of health insurance guidelines for the treatment of symptomatic varicose veins. 61
23559591 2014

Variations for Vein Disease

Expression for Vein Disease

Search GEO for disease gene expression data for Vein Disease.

Pathways for Vein Disease

GO Terms for Vein Disease

Cellular components related to Vein Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.97 VEGFA SST SERPINC1 PROS1 PROC PLG
2 collagen-containing extracellular matrix GO:0062023 9.77 SERPINC1 PLG MFAP5 F3 F2
3 endoplasmic reticulum lumen GO:0005788 9.73 SERPINC1 PROC F5 F2 ALB AFP
4 blood microparticle GO:0072562 9.72 SERPINC1 PROS1 PLG F2 ALB
5 extracellular space GO:0005615 9.47 VEGFA SST SERPINC1 PROS1 PROC PLG
6 platelet alpha granule lumen GO:0031093 9.35 VEGFA PROS1 PLG F5 ALB

Biological processes related to Vein Disease according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.8 SERPINC1 PROC F5 EPAS1 ALB AFP
2 ER to Golgi vesicle-mediated transport GO:0006888 9.71 PROS1 PROC F5 F2
3 cellular protein metabolic process GO:0044267 9.7 SERPINC1 PROC PLG F5 F2 ALB
4 platelet degranulation GO:0002576 9.65 VEGFA PROS1 PLG F5 ALB
5 sodium ion export across plasma membrane GO:0036376 9.55 ATP4A ATP12A
6 cellular potassium ion homeostasis GO:0030007 9.54 ATP4A ATP12A
7 fibrinolysis GO:0042730 9.54 PROS1 PLG F2
8 positive regulation of positive chemotaxis GO:0050927 9.52 VEGFA F3
9 regulation of blood coagulation GO:0030193 9.51 SERPINC1 F2
10 blood coagulation GO:0007596 9.5 SERPINC1 PROS1 PROC PLG F5 F3
11 negative regulation of fibrinolysis GO:0051918 9.49 PLG F2
12 surfactant homeostasis GO:0043129 9.48 VEGFA EPAS1
13 negative regulation of cell-cell adhesion mediated by cadherin GO:2000048 9.46 VEGFA PLG
14 transport GO:0006810 9.43 ALB AFP
15 hemostasis GO:0007599 9.17 SERPINC1 PROS1 PROC PLG F5 F3

Molecular functions related to Vein Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.26 ATP4A ATP12A
2 serine-type endopeptidase activity GO:0004252 9.26 PROC PLG F3 F2
3 potassium-transporting ATPase activity GO:0008556 9.16 ATP4A ATP12A
4 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Vein Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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