MCID: VND001
MIFTS: 42

Vein Disease

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Vein Disease

MalaCards integrated aliases for Vein Disease:

Name: Vein Disease 12 15
Disorder of Vein 71

Classifications:



External Ids:

Disease Ontology 12 DOID:866
ICD9CM 34 453
UMLS 71 C0155774 C0235522

Summaries for Vein Disease

Disease Ontology : 12 A vascular disease that is located in a vein.

MalaCards based summary : Vein Disease, also known as disorder of vein, is related to varicose veins and venous insufficiency, and has symptoms including vein pain An important gene associated with Vein Disease is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Heparin and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include a vein, lymph node and heart, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Vein Disease

Diseases in the Vein Disease family:

Congenital Systemic Veins Anomaly

Diseases related to Vein Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 487)
# Related Disease Score Top Affiliating Genes
1 varicose veins 32.9 VEGFA SERPINC1 MTHFR F5 F2
2 venous insufficiency 32.8 VEGFA MTHFR F5 F2 CRP
3 chronic venous insufficiency 30.7 VEGFA F2 CRP
4 pulmonary embolism 30.2 SERPINC1 PROS1 PROC MTHFR F5 F3
5 protein s deficiency 30.0 SERPINC1 PROS1 PROC MTHFR F5 F3
6 thrombophlebitis 30.0 SERPINC1 PROS1 PROC PLG MTHFR F5
7 thrombosis 29.7 SERPINC1 SERPINA3 PROS1 PROC PLG MTHFR
8 venous malformations, multiple cutaneous and mucosal 11.0
9 non-a-e hepatitis 10.8 F2 ALB
10 antipyrine metabolism 10.8 F2 ALB
11 paracetamol poisoning 10.8 F5 F2
12 arteritic anterior ischemic optic neuropathy 10.8 MTHFR F5 F2
13 prothrombin-related thrombophilia 10.8 MTHFR F2
14 cholecystitis 10.7 GPT F2 ALB
15 amaurosis fugax 10.7 MTHFR F5
16 neonatal stroke 10.7 PROC MTHFR
17 hepatoportal sclerosis 10.7 GPT F2
18 dipetalonemiasis 10.7 GPT ALB
19 cryptogenic cirrhosis 10.7 MTHFR F5 F2
20 hemifacial spasm 10.7 VEGFA MTHFR
21 orbital osteomyelitis 10.7 F2 CRP
22 small intestine diverticulitis 10.7 F2 CRP
23 femoral vein thrombophlebitis 10.7 PROC F2
24 prothrombin deficiency, congenital 10.7 SERPINC1 F5 F2
25 chronic duodenal ileus 10.7 CRP ALB
26 acquired hemophilia 10.7 F5 F3
27 acquired hemophilia a 10.7 F5 F3
28 papillary adenofibroma 10.7 F3 F2 AFP
29 pylorus cancer 10.7 SST ALB
30 hypertensive encephalopathy 10.7 VEGFA F2 ALB
31 ileus 10.7 SST F2 CRP
32 porencephaly 10.7 MTHFR F5 F2
33 meningococcemia 10.7 SERPINC1 PROC F5
34 dic in newborn 10.7 SERPINC1 F3 F2
35 acquired angioedema 10.7 F5 CRP
36 infantile liver failure syndrome 1 10.7 GPT F2 ALB
37 waterhouse-friderichsen syndrome 10.7 SERPINC1 F3 F2
38 sticky platelet syndrome 10.7 SERPINC1 F5
39 achenbach syndrome 10.7 F3 F2 CRP
40 hematocele of tunica vaginalis testis 10.7 F2 CRP AFP
41 heparin-induced thrombocytopenia 10.7 SERPINC1 F3
42 prothrombin deficiency 10.7 SERPINC1 F3 F2
43 medulloadrenal hyperfunction 10.7 PLG F3
44 sneddon syndrome 10.7 SERPINC1 F5 F2
45 synovial angioma 10.7 F3 F2 CRP
46 thoracic outlet syndrome 10.7 SERPINC1 PLG F2
47 renal pelvis squamous cell carcinoma 10.7 F3 F2 CRP
48 intravascular papillary endothelial hyperplasia 10.7 VEGFA SERPINA3
49 heterophyiasis 10.7 GPT ALB
50 dysfibrinogenemia, congenital 10.7 SERPINC1 F5 F2

Graphical network of the top 20 diseases related to Vein Disease:



Diseases related to Vein Disease

Symptoms & Phenotypes for Vein Disease

UMLS symptoms related to Vein Disease:


vein pain

MGI Mouse Phenotypes related to Vein Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 AFP ALB ATP12A ATP4A CRP EVL
2 cardiovascular system MP:0005385 10.11 ALB CRP EVL F2 F3 F5
3 immune system MP:0005387 10 ALB ATP4A CRP EVL F2 F3
4 mortality/aging MP:0010768 9.83 AFP ALB ATP4A EVL F2 F3
5 liver/biliary system MP:0005370 9.81 AFP ALB F5 MTHFR PLG PROC
6 nervous system MP:0003631 9.36 EVL F2 F3 F5 MTHFR PLG

Drugs & Therapeutics for Vein Disease

Drugs for Vein Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational 9005-49-6 46507594 772
2
Ethanol Approved 64-17-5 702
3
Sodium Tetradecyl Sulfate Approved, Investigational 1191-50-0, 139-88-8 5248 14492
4
Polidocanol Approved 9002-92-0
5 calcium heparin
6 Calamus
7 Sclerosing Solutions
8 Pharmaceutical Solutions

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 FOAM-study Cost Minimization Study Comparing Surgery Versus Duplex Guided Foam Sclerotherapy of Varicose Veins: a Randomized Controlled Study Completed NCT01103258
2 Pen Torch Transillumination: Shedding Light on Difficult Venepuncture Completed NCT02570568
3 Pilot Randomised Controlled Trial Evaluating the Potential Benefit of a One Stop Vein Clinic (OSVeC) Recruiting NCT02557542 Foam sclerotherapy (Polidocanol or Sodium Tetradecyl Sulphate)
4 Allogeneic Left Atrial and Pulmonary Vein Transplant for Pulmonary Vein Stenosis Recruiting NCT03456193
5 The Role of Pyroptosis in Chronic Venous Disease and Its Pathophysiological Implication Active, not recruiting NCT03744858
6 Patients Commitment to Compression Therapy Active, not recruiting NCT04096729

Search NIH Clinical Center for Vein Disease

Genetic Tests for Vein Disease

Anatomical Context for Vein Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Vein Disease:

19
A Vein

MalaCards organs/tissues related to Vein Disease:

40
Lymph Node, Heart, Liver, Skin, Myeloid, Neutrophil

Publications for Vein Disease

Articles related to Vein Disease:

(show top 50) (show all 205)
# Title Authors PMID Year
1
Capillary-venule malformation a microfistulous variant of arteriovenous malformation. 61
32470616 2020
2
Left temporal hemorrhage caused by cerebral venous reflux of a brachio-brachial hemodialysis fistula. 61
32448996 2020
3
The biomechanical impact of hip movement on iliofemoral venous anatomy and stenting for deep venous thrombosis. 61
32321693 2020
4
Novel Approach to Treatment of Chronic Iliocaval Occlusion Utilizing Covered Stents. 61
32173477 2020
5
Votive Reliefs of Lower Extremities Disorders: A Brief Review. 61
32211256 2020
6
Lower Extremity Venous Stent Placement: A Large Retrospective Single-Center Analysis. 61
31542273 2020
7
FEATURES OF CLINICAL SYMPTOMS AND SIGNS, HEMATOLOGICAL AND BIOCHEMICAL PARAMETERS IN CHILDREN WITH JOINT HYPERMOBILITY IN A LATE PERIOD UPON THE CHORNOBYL NPP ACCIDENT. 61
31841477 2019
8
Single- versus multiple-stage catheter-directed thrombolysis for acute iliofemoral deep venous thrombosis does not have an impact on iliac vein stent length or patency rates. 61
31495769 2019
9
Foam Sclerotherapy: An Emerging, Minimally Invasive And Safe Modality Of Treatment For Varicose Veins. 61
31965766 2019
10
[Thromboembolic vein disease (TVD): antithrombotic therapy choice in ASL TO3.] 61
31593179 2019
11
Surgical and endovascular central venous reconstruction combined with thoracic outlet decompression in highly symptomatic patients. 61
30442583 2019
12
[Venous wall weackness pathogenesis in varicose vein disease]. 61
31626242 2019
13
Early clinical experience using telemedicine for the management of patients with varicose vein disease. 61
28969485 2019
14
Clinical and Genetic Determinants of Varicose Veins. 61
30566020 2018
15
Commentary on the article "A prospective study of a vein sparing technique for the management of varicose vein disease" by M Zmudzinski et al. 61
29122236 2018
16
Molecular characterization and detection of a novel vitivirus infecting blackberry. 61
29987381 2018
17
Present and future options for treatment of infrainguinal deep vein disease. 61
30007531 2018
18
The effectiveness of various interventions versus standard stripping in patients with varicose veins in terms of quality of life. 61
28720052 2018
19
DNA methylation and gene expression profiling reveal MFAP5 as a regulatory driver of extracellular matrix remodeling in varicose vein disease. 61
30070582 2018
20
Cumulative Effect of Preoperative Risk Factors on Mortality After Pediatric Heart Transplantation. 61
29684375 2018
21
Implementation of a virtual vascular clinic with point-of-care ultrasound in an integrated health care system. 61
29398312 2018
22
Suppressed networks of inflammatory mediators characterize chronic venous insufficiency. 61
29439934 2018
23
Characterization of the complete genome of euonymus yellow vein associated virus, a distinct member of the genus Potexvirus, family Alphaflexiviridae, isolated from Euonymus bungeanus Maxim in Liaoning, Northern China. 61
29079952 2018
24
Cost-effectiveness analysis of five procedures for great saphenous vein reflux in a Norwegian healthcare setting or societal setting. 61
30263121 2018
25
Small RNA-Seq to Characterize Viruses Responsible of Lettuce Big Vein Disease in Spain. 61
30622528 2018
26
Prevalence and Risk Factors for Chronic Venous Disease in the General Russian Population. 61
29031868 2017
27
Truncal varicose vein diameter and patient-reported outcome measures. 61
28766692 2017
28
Incidence of the MTHFR polymorphisms in patients with varicose veins. 61
30944507 2017
29
Development of reliable detection assays for blueberry mosaic- and blackberry vein banding- associated viruses based on their population structures. 61
28754569 2017
30
Characterization of lettuce big-vein associated virus and Mirafiori lettuce big-vein virus infecting lettuce in Saudi Arabia. 61
28299485 2017
31
CHIVA - A prospective study of a vein sparing technique for the management of varicose vein disease. 61
28431588 2017
32
First 10-month results of the Vascular Quality Initiative Varicose Vein Registry. 61
28411696 2017
33
A new, widespread emaravirus discovered in blackberry. 61
28396285 2017
34
Vector Transmission Alone Fails to Explain the Potato Yellow Vein Virus Epidemic among Potato Crops in Colombia. 61
28993785 2017
35
[Lower extremity venous diseases in primary knee osteoarthritis]. 61
28631699 2017
36
Hemodynamics-based treatment of varices: A therapeutic concept counteracting the intrinsic tendency of varicose veins to recur. 61
27581714 2016
37
Nonthermal, Nontumescent Endovenous Treatment of Varicose Veins. 61
27421205 2016
38
Development of marker-free transgenic lettuce resistant to Mirafiori lettuce big-vein virus. 61
27055463 2016
39
A review of a new Dutch guideline for management of recurrent varicose veins. 61
26916778 2016
40
Long-term follow-up for different varicose vein therapies: is surgery still the best? 61
26916779 2016
41
Effects of Fentanyl and Morphine on Shivering During Spinal Anesthesia in Patients Undergoing Endovenous Ablation of Varicose Veins. 61
26871238 2016
42
Real-World Assessment of Interventional Treatment Timing and Outcomes for Varicose Veins: A Retrospective Claims Analysis. 61
26654450 2016
43
[The influence of the training of the muscular component of the musculo-venous pump in the lower extremities on the clinical course of varicose vein disease]. 61
28091490 2016
44
Radiofrequency ablation or stripping of large-diameter incompetent great saphenous varicose veins with C2 or C3 disease. 61
26946895 2016
45
ICD Leads Extraction and Clearing of Access Way in a Patient With Superior Vena Cava Syndrome: Building A Tunnel. 61
26402803 2015
46
Management of perforator vein aneurysms in the lower extremities. 61
26992305 2015
47
NONICHEMIC CENTRAL RETINAL VEIN OCCLUSION ASSOCIATED WITH HEREDITARY THROMBOPHYLIA. 61
26978887 2015
48
Association of tomato leaf curl New Delhi virus DNA-B with bhendi yellow vein mosaic virus in okra showing yellow vein mosaic disease symptoms. 61
26104329 2015
49
Thrombophilic mutations as risk factor for retinal vein occlusion: a case-control study. 61
24569626 2015
50
Guidelines of the First International Consensus Conference on Endovenous Thermal Ablation for Varicose Vein Disease--ETAV Consensus Meeting 2012. 61
24534341 2015

Variations for Vein Disease

Expression for Vein Disease

Search GEO for disease gene expression data for Vein Disease.

Pathways for Vein Disease

GO Terms for Vein Disease

Cellular components related to Vein Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.07 VEGFA SST SERPINC1 SERPINA3 PROS1 PROC
2 endoplasmic reticulum lumen GO:0005788 9.8 SERPINC1 PROC F5 F2 ALB AFP
3 collagen-containing extracellular matrix GO:0062023 9.77 SERPINC1 SERPINA3 PLG F3 F2
4 blood microparticle GO:0072562 9.63 SERPINC1 SERPINA3 PROS1 PLG F2 ALB
5 extracellular space GO:0005615 9.5 VEGFA SST SERPINC1 SERPINA3 PROS1 PROC
6 platelet alpha granule lumen GO:0031093 9.43 VEGFA SERPINA3 PROS1 PLG F5 ALB

Biological processes related to Vein Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.8 SERPINC1 PROC F5 ALB AFP
2 ER to Golgi vesicle-mediated transport GO:0006888 9.73 PROS1 PROC F5 F2
3 platelet degranulation GO:0002576 9.73 VEGFA SERPINA3 PROS1 PLG F5 ALB
4 cellular protein metabolic process GO:0044267 9.7 SERPINC1 PROC PLG F5 F2 ALB
5 acute-phase response GO:0006953 9.54 SERPINA3 F2 CRP
6 fibrinolysis GO:0042730 9.5 PROS1 PLG F2
7 blood coagulation GO:0007596 9.5 SERPINC1 PROS1 PROC PLG F5 F3
8 positive regulation of positive chemotaxis GO:0050927 9.49 VEGFA F3
9 negative regulation of cell-cell adhesion mediated by cadherin GO:2000048 9.48 VEGFA PLG
10 negative regulation of fibrinolysis GO:0051918 9.46 PLG F2
11 hemostasis GO:0007599 9.17 SERPINC1 PROS1 PROC PLG F5 F3

Molecular functions related to Vein Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.26 ATP4A ATP12A
2 serine-type endopeptidase activity GO:0004252 9.26 PROC PLG F3 F2
3 potassium-transporting ATPase activity GO:0008556 9.16 ATP4A ATP12A
4 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Vein Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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